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Conserved domains on  [gi|1370471475|ref|XP_016880290|]
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tetratricopeptide repeat protein 19, mitochondrial isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
230-311 1.43e-08

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 51.23  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 230 ANTHLLLGMCLDACARYLlfskqpsQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLA 309
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYD-------EALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75


                  ..
gi 1370471475 310 RQ 311
Cdd:pfam13424  76 EK 77
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 68-347 1.30e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.91  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475  68 RPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYT-YDLMANLA 146
Cdd:COG3914     9 LAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAlLELAALLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 147 FIRGQLENAEQLFKATMsyllgggmkQEDNAIIEISLKLASIYAAQNRQEFAVAgyefcisTLEEKIEREKELAEdimsv 226
Cdd:COG3914    89 QALGRYEEALALYRRAL---------ALNPDNAEALFNLGNLLLALGRLEEALA-------ALRRALALNPDFAE----- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 227 eekanTHLLLGMCLDACaryllfsKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAS 306
Cdd:COG3914   148 -----AYLNLGEALRRL-------GRLEEAIAALRRALEL--------DPDNAEALNNLGNALQDLGRLEEAIAAYRRAL 207

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370471475 307 DLArqinhPELHMVLSNLAAVLMHRAATTVLGPSKEAKATL 347
Cdd:COG3914   208 ELD-----PDNADAHSNLLFALRQACDWEVYDRFEELLAAL 243
 
Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
230-311 1.43e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 51.23  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 230 ANTHLLLGMCLDACARYLlfskqpsQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLA 309
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYD-------EALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75


                  ..
gi 1370471475 310 RQ 311
Cdd:pfam13424  76 EK 77
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 68-347 1.30e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.91  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475  68 RPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYT-YDLMANLA 146
Cdd:COG3914     9 LAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAlLELAALLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 147 FIRGQLENAEQLFKATMsyllgggmkQEDNAIIEISLKLASIYAAQNRQEFAVAgyefcisTLEEKIEREKELAEdimsv 226
Cdd:COG3914    89 QALGRYEEALALYRRAL---------ALNPDNAEALFNLGNLLLALGRLEEALA-------ALRRALALNPDFAE----- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 227 eekanTHLLLGMCLDACaryllfsKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAS 306
Cdd:COG3914   148 -----AYLNLGEALRRL-------GRLEEAIAALRRALEL--------DPDNAEALNNLGNALQDLGRLEEAIAAYRRAL 207

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370471475 307 DLArqinhPELHMVLSNLAAVLMHRAATTVLGPSKEAKATL 347
Cdd:COG3914   208 ELD-----PDNADAHSNLLFALRQACDWEVYDRFEELLAAL 243
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 260-325 1.35e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 40.67  E-value: 1.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370471475 260 YEKALQISEEIQ---------GERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHMVLSNLA 325
Cdd:NF040586  450 YEEARELDEDTLerqrrvlglGEDHPHTLMTAGGLGADLRALGRFREALELDEETLERHRRVfgeDHPRTLRAANNLA 527
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 243-331 1.41e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 40.67  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 243 CARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAY------IYMQRASDLARQiNHPE 316
Cdd:NF040586  398 QVRYLYLRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEAReldedtLERQRRVLGLGE-DHPH 476

                          90
                  ....*....|....*
gi 1370471475 317 LHMVLSNLAAVLMHR 331
Cdd:NF040586  477 TLMTAGGLGADLRAL 491
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 255-325 3.25e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 39.52  E-value: 3.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370471475 255 QAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI----NHPELHMVLSNLA 325
Cdd:NF040586  538 EALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVlggpDHPDTLRAAKSLA 612
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 102-315 4.50e-03

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 38.45  E-value: 4.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 102 RAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYdLMANLAFIRGQLENAEQLFKATMSYLLGGGMKqedNAIIEI 181
Cdd:pfam17874   7 RAQLAISKGDAERALELAEQALALLPEDDLLARGLATF-VLGEAYLCLGDLDAALQAMREAEALARRADSP---HVTLWA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 182 SLKLASIYAAQNRQEFAVAGYEFCIstleeKIEREKELAEDIMSveekanthlllGMCLDACARYLLFSKQPSQAQRMYE 261
Cdd:pfam17874  83 LLQQGEILRAQGRLHQALETYQQAL-----QLARDHGLQHLPLH-----------GFLLVGLADLLYEWNDLEEAEQHAQ 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370471475 262 KALQISEEIQGERHPQTIVLMSDLATtldAQGRFDEAYIYMQRASDLARQINHP 315
Cdd:pfam17874 147 QGIQLGRQWEPDAAVDAYVLLARIAL---AQGELEEALTLLRRAELLARQSFFH 197
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 252-328 4.68e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 38.75  E-value: 4.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 252 QPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQIN---HPELHMVLSNLAAVL 328
Cdd:NF040586  620 RLEEALELAEDTYERYRRRFGPDHPDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLgedHPFTLACRNNLAVLL 699
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 244-326 8.45e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.14  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 244 ARYLLFSKQPSQAQRMYEKALQISeeiqgerhPQTIVLMSDLATTLDAQGRFDEAYIYMQRAsdLARQINHPELHMVLSN 323
Cdd:COG4235    24 GRAYLRLGRYDEALAAYEKALRLD--------PDNADALLDLAEALLAAGDTEEAEELLERA--LALDPDNPEALYLLGL 93


                  ...
gi 1370471475 324 LAA 326
Cdd:COG4235    94 AAF 96
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 244-328 9.48e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 37.98  E-value: 9.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 244 ARYLLFSKQPSQAQRMYEKALQ-ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHM 319
Cdd:NF040586  569 ARDLRELGRYAEALDLLEEALErYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRfgpDHPDTLA 648


                  ....*....
gi 1370471475 320 VLSNLAAVL 328
Cdd:NF040586  649 AALSLANDL 657
 
Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
230-311 1.43e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 51.23  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 230 ANTHLLLGMCLDACARYLlfskqpsQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLA 309
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYD-------EALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALA 75


                  ..
gi 1370471475 310 RQ 311
Cdd:pfam13424  76 EK 77
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 68-347 1.30e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.91  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475  68 RPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYT-YDLMANLA 146
Cdd:COG3914     9 LAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAlLELAALLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 147 FIRGQLENAEQLFKATMsyllgggmkQEDNAIIEISLKLASIYAAQNRQEFAVAgyefcisTLEEKIEREKELAEdimsv 226
Cdd:COG3914    89 QALGRYEEALALYRRAL---------ALNPDNAEALFNLGNLLLALGRLEEALA-------ALRRALALNPDFAE----- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 227 eekanTHLLLGMCLDACaryllfsKQPSQAQRMYEKALQIseeiqgerHPQTIVLMSDLATTLDAQGRFDEAYIYMQRAS 306
Cdd:COG3914   148 -----AYLNLGEALRRL-------GRLEEAIAALRRALEL--------DPDNAEALNNLGNALQDLGRLEEAIAAYRRAL 207

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1370471475 307 DLArqinhPELHMVLSNLAAVLMHRAATTVLGPSKEAKATL 347
Cdd:COG3914   208 ELD-----PDNADAHSNLLFALRQACDWEVYDRFEELLAAL 243
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 260-325 1.35e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 40.67  E-value: 1.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370471475 260 YEKALQISEEIQ---------GERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHMVLSNLA 325
Cdd:NF040586  450 YEEARELDEDTLerqrrvlglGEDHPHTLMTAGGLGADLRALGRFREALELDEETLERHRRVfgeDHPRTLRAANNLA 527
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 243-331 1.41e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 40.67  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 243 CARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAY------IYMQRASDLARQiNHPE 316
Cdd:NF040586  398 QVRYLYLRGDYESARDLAERALERWRERLGPDDRQTLRLRFHLANALRSLGRYEEAReldedtLERQRRVLGLGE-DHPH 476

                          90
                  ....*....|....*
gi 1370471475 317 LHMVLSNLAAVLMHR 331
Cdd:NF040586  477 TLMTAGGLGADLRAL 491
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 255-325 3.25e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 39.52  E-value: 3.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370471475 255 QAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI----NHPELHMVLSNLA 325
Cdd:NF040586  538 EALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVlggpDHPDTLRAAKSLA 612
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 102-315 4.50e-03

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 38.45  E-value: 4.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 102 RAKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYdLMANLAFIRGQLENAEQLFKATMSYLLGGGMKqedNAIIEI 181
Cdd:pfam17874   7 RAQLAISKGDAERALELAEQALALLPEDDLLARGLATF-VLGEAYLCLGDLDAALQAMREAEALARRADSP---HVTLWA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 182 SLKLASIYAAQNRQEFAVAGYEFCIstleeKIEREKELAEDIMSveekanthlllGMCLDACARYLLFSKQPSQAQRMYE 261
Cdd:pfam17874  83 LLQQGEILRAQGRLHQALETYQQAL-----QLARDHGLQHLPLH-----------GFLLVGLADLLYEWNDLEEAEQHAQ 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1370471475 262 KALQISEEIQGERHPQTIVLMSDLATtldAQGRFDEAYIYMQRASDLARQINHP 315
Cdd:pfam17874 147 QGIQLGRQWEPDAAVDAYVLLARIAL---AQGELEEALTLLRRAELLARQSFFH 197
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 252-328 4.68e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 38.75  E-value: 4.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 252 QPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQIN---HPELHMVLSNLAAVL 328
Cdd:NF040586  620 RLEEALELAEDTYERYRRRFGPDHPDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLgedHPFTLACRNNLAVLL 699
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 134-326 5.93e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.79  E-value: 5.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 134 AITYTYDLMANLAFIRGQLENAEQLFKAtmsyllgggMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKI 213
Cdd:COG2956     6 AAALGWYFKGLNYLLNGQPDKAIDLLEE---------ALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 214 EREKELAEDIMSVEEKANTHLLLGMCL-----DACARYLLFSKQpsQAQRMYEKALQISEEIQgERHPQTIVLMSDLATT 288
Cdd:COG2956    77 EALLELAQDYLKAGLLDRAEELLEKLLeldpdDAEALRLLAEIY--EQEGDWEKAIEVLERLL-KLGPENAHAYCELAEL 153

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1370471475 289 LDAQGRFDEAYIYMQRAsdLARQINHPELHMVLSNLAA 326
Cdd:COG2956   154 YLEQGDYDEAIEALEKA--LKLDPDCARALLLLAELYL 189
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 244-326 8.45e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.14  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 244 ARYLLFSKQPSQAQRMYEKALQISeeiqgerhPQTIVLMSDLATTLDAQGRFDEAYIYMQRAsdLARQINHPELHMVLSN 323
Cdd:COG4235    24 GRAYLRLGRYDEALAAYEKALRLD--------PDNADALLDLAEALLAAGDTEEAEELLERA--LALDPDNPEALYLLGL 93


                  ...
gi 1370471475 324 LAA 326
Cdd:COG4235    94 AAF 96
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 244-328 9.48e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 37.98  E-value: 9.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370471475 244 ARYLLFSKQPSQAQRMYEKALQ-ISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHM 319
Cdd:NF040586  569 ARDLRELGRYAEALDLLEEALErYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRfgpDHPDTLA 648


                  ....*....
gi 1370471475 320 VLSNLAAVL 328
Cdd:NF040586  649 AALSLANDL 657
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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