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Conserved domains on  [gi|1034596189|ref|XP_016879235|]
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axin-1 isoform X7 [Homo sapiens]

Protein Classification

Axin_b-cat_bind and DIX domain-containing protein( domain architecture ID 10556030)

Axin_b-cat_bind and DIX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DIX pfam00778
DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in ...
 432-508 9.71e-34

DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in homo- and hetero-oligomerization. It is involved in the homo- oligomerization of mouse axin. The axin DIX domain also interacts with the dishevelled DIX domain. The DIX domain has also been called the DAX domain.


:

Pssm-ID: 459936  Cd Length: 77  Bit Score: 122.25  E-value: 9.71e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034596189 432 SIVVAYYFCGEPIPYRT--LVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCgvVFEEVREDEAVLPVFEEKIIGKV 508
Cdd:pfam00778   1 ETKVIYYLCDEPVPYRIkiHKPGGQITLGDFKELLPKKGNYRYFFKTLDPEFGT--VKEEITDDDDILPLWEGKIVAKV 77
Axin_b-cat_bind pfam08833
Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is ...
 115-146 1.25e-09

Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex. It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin.


:

Pssm-ID: 462616  Cd Length: 35  Bit Score: 53.47  E-value: 1.25e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1034596189 115 ENPESILDEHVQRVLRTPGRQSPG---PGHRSPDS 146
Cdd:pfam08833   1 DNPQSILDEHVSRVWKTPGCQSPGrhsPRSRSPDS 35
 
Name Accession Description Interval E-value
DIX pfam00778
DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in ...
 432-508 9.71e-34

DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in homo- and hetero-oligomerization. It is involved in the homo- oligomerization of mouse axin. The axin DIX domain also interacts with the dishevelled DIX domain. The DIX domain has also been called the DAX domain.


Pssm-ID: 459936  Cd Length: 77  Bit Score: 122.25  E-value: 9.71e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034596189 432 SIVVAYYFCGEPIPYRT--LVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCgvVFEEVREDEAVLPVFEEKIIGKV 508
Cdd:pfam00778   1 ETKVIYYLCDEPVPYRIkiHKPGGQITLGDFKELLPKKGNYRYFFKTLDPEFGT--VKEEITDDDDILPLWEGKIVAKV 77
DAX smart00021
Domain present in Dishevelled and axin; Domain of unknown function.
 430-512 1.84e-33

Domain present in Dishevelled and axin; Domain of unknown function.


Pssm-ID: 197474  Cd Length: 83  Bit Score: 121.75  E-value: 1.84e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596189  430 CDSIVVAYYFCGEPIPYRTLVRGRA--VTLGQFKELLTKKGsYRYYFKKVSDEFDcGVVFEEVREDEAVLPVFEEKIIGK 507
Cdd:smart00021   1 CSETKVIYHLDDEETPYLVKVPVPAerVTLGDFKEVLTKKN-YKYYFKSMDDDFG-GVVKEEIRDDSARLPCFNGRVVSW 78


                   ....*
gi 1034596189  508 VEKVD 512
Cdd:smart00021  79 LVSVE 83
Axin_b-cat_bind pfam08833
Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is ...
 115-146 1.25e-09

Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex. It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin.


Pssm-ID: 462616  Cd Length: 35  Bit Score: 53.47  E-value: 1.25e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1034596189 115 ENPESILDEHVQRVLRTPGRQSPG---PGHRSPDS 146
Cdd:pfam08833   1 DNPQSILDEHVSRVWKTPGCQSPGrhsPRSRSPDS 35
 
Name Accession Description Interval E-value
DIX pfam00778
DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in ...
 432-508 9.71e-34

DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in homo- and hetero-oligomerization. It is involved in the homo- oligomerization of mouse axin. The axin DIX domain also interacts with the dishevelled DIX domain. The DIX domain has also been called the DAX domain.


Pssm-ID: 459936  Cd Length: 77  Bit Score: 122.25  E-value: 9.71e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034596189 432 SIVVAYYFCGEPIPYRT--LVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCgvVFEEVREDEAVLPVFEEKIIGKV 508
Cdd:pfam00778   1 ETKVIYYLCDEPVPYRIkiHKPGGQITLGDFKELLPKKGNYRYFFKTLDPEFGT--VKEEITDDDDILPLWEGKIVAKV 77
DAX smart00021
Domain present in Dishevelled and axin; Domain of unknown function.
 430-512 1.84e-33

Domain present in Dishevelled and axin; Domain of unknown function.


Pssm-ID: 197474  Cd Length: 83  Bit Score: 121.75  E-value: 1.84e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034596189  430 CDSIVVAYYFCGEPIPYRTLVRGRA--VTLGQFKELLTKKGsYRYYFKKVSDEFDcGVVFEEVREDEAVLPVFEEKIIGK 507
Cdd:smart00021   1 CSETKVIYHLDDEETPYLVKVPVPAerVTLGDFKEVLTKKN-YKYYFKSMDDDFG-GVVKEEIRDDSARLPCFNGRVVSW 78


                   ....*
gi 1034596189  508 VEKVD 512
Cdd:smart00021  79 LVSVE 83
Axin_b-cat_bind pfam08833
Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is ...
 115-146 1.25e-09

Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex. It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin.


Pssm-ID: 462616  Cd Length: 35  Bit Score: 53.47  E-value: 1.25e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1034596189 115 ENPESILDEHVQRVLRTPGRQSPG---PGHRSPDS 146
Cdd:pfam08833   1 DNPQSILDEHVSRVWKTPGCQSPGrhsPRSRSPDS 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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