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Conserved domains on  [gi|1034595780|ref|XP_016879093|]
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sulfotransferase 1A1 isoform X1 [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-293 1.02e-102

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 300.80  E-value: 1.02e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780  38 PDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFM---RVPFLEF----KAPGIPSGMETLKDTPAPRLLKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780 111 LALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLY 190
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780 191 LFYEDMKEgpsaaqNPKREIQKILEFVGRSLPEETVDFVVQHTSFKEMKKNPMTNYTTVPQEfmdhsISPFMRKGMAGDW 270
Cdd:pfam00685 161 LRYEDLKK------DPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDW 229

                         250       260
                  ....*....|....*....|...
gi 1034595780 271 KTTFTVAQNERFDADYAEKMAGC 293
Cdd:pfam00685 230 KNYFTPEQAEKFDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-293 1.02e-102

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 300.80  E-value: 1.02e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780  38 PDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFM---RVPFLEF----KAPGIPSGMETLKDTPAPRLLKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780 111 LALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLY 190
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780 191 LFYEDMKEgpsaaqNPKREIQKILEFVGRSLPEETVDFVVQHTSFKEMKKNPMTNYTTVPQEfmdhsISPFMRKGMAGDW 270
Cdd:pfam00685 161 LRYEDLKK------DPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDW 229

                         250       260
                  ....*....|....*....|...
gi 1034595780 271 KTTFTVAQNERFDADYAEKMAGC 293
Cdd:pfam00685 230 KNYFTPEQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 34-295 3.55e-29

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 113.86  E-value: 3.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780  34 FQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRaPIFMR-----VPFLEFKAPGIPSgMETLKDTPAPrLLKTH 108
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780 109 LPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVH--PEPGTWDSFlEKFMVGEVSYGSWYQHVQEWWELSRTH 186
Cdd:PLN02164  152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQqgPLNSLEESF-DMFCRGLSVYGPYLDHVLGYWKAYQEN 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780 187 P--VLYLFYEDMKegpsaaQNPKREIQKILEFVGRSLPEE-----TVDFVVQHTSFkEMKKNPMTNYTTVPQEFMD--HS 257
Cdd:PLN02164  231 PdrILFLKYETMR------ADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSF-ETLKNLEANKGEKDREDRPavYA 303

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1034595780 258 ISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSL 295
Cdd:PLN02164  304 NSAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-293 1.02e-102

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 300.80  E-value: 1.02e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780  38 PDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFM---RVPFLEF----KAPGIPSGMETLKDTPAPRLLKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780 111 LALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLY 190
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780 191 LFYEDMKEgpsaaqNPKREIQKILEFVGRSLPEETVDFVVQHTSFKEMKKNPMTNYTTVPQEfmdhsISPFMRKGMAGDW 270
Cdd:pfam00685 161 LRYEDLKK------DPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDW 229

                         250       260
                  ....*....|....*....|...
gi 1034595780 271 KTTFTVAQNERFDADYAEKMAGC 293
Cdd:pfam00685 230 KNYFTPEQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 34-295 3.55e-29

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 113.86  E-value: 3.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780  34 FQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRaPIFMR-----VPFLEFKAPGIPSgMETLKDTPAPrLLKTH 108
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780 109 LPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVH--PEPGTWDSFlEKFMVGEVSYGSWYQHVQEWWELSRTH 186
Cdd:PLN02164  152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQqgPLNSLEESF-DMFCRGLSVYGPYLDHVLGYWKAYQEN 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780 187 P--VLYLFYEDMKegpsaaQNPKREIQKILEFVGRSLPEE-----TVDFVVQHTSFkEMKKNPMTNYTTVPQEFMD--HS 257
Cdd:PLN02164  231 PdrILFLKYETMR------ADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSF-ETLKNLEANKGEKDREDRPavYA 303

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1034595780 258 ISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSL 295
Cdd:PLN02164  304 NSAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
47-223 5.78e-08

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 51.52  E-value: 5.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780  47 PKSGTTWVSQILDmiyqggdlekCHRAPIFMR-----VPFLEFKAPGIPSGMETL--KDTPAPRLLK---THLP-----L 111
Cdd:pfam13469   7 PRSGTTLLHRLLA----------AHPDVRPPEetwfvIPRILALLQAWGKSLEALarVPSYARWLCDkspSHLFhldllL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595780 112 ALLPQTlldqkvKVVYVARNAKDVAVSyyHFYHMAKVHPEPgtWDSFLEKFMVGEVSYgsWYQHVQEWWELSRTHP---V 188
Cdd:pfam13469  77 KAFPDA------KFIHLHRDPVDTVIS--SYCSLFGFTLSS--YSTAFLRDIGLALAR--WSRAYERLMAARARVPpgrF 144

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1034595780 189 LYLFYEDMkegpsaAQNPKREIQKILEFVGRSLPE 223
Cdd:pfam13469 145 LDVRYEDL------VADPEGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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