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Conserved domains on  [gi|1034590227|ref|XP_016877550|]
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WD repeat-containing protein 72 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-595 1.28e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 84.69  E-value: 1.28e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEGGSLVKdspphkVLKGHHQSVTSLLYPHglssklDQSWML 483
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLR------TLKGHTGPVRDVAASA------DGTYLA 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  484 SGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMI 563
Cdd:cd00200     68 SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1034590227  564 KWHPVENFLIVGCADDSVYIWEIETG----TLERHE 595
Cdd:cd00200    142 AFSPDGTFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-191 3.19e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 3.19e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   13 QKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLararDFS-KQPYIVSAAENGEMCV 91
Cdd:cd00200     47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKV 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   92 WNVTNGQCmeKATLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLIIDAKTLAVVHSFRSSQfpDWINCMCIVHSmri 170
Cdd:cd00200    120 WDVETGKC--LTTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHT--GEVNSVAFSPD--- 188

                          170       180
                   ....*....|....*....|.
gi 1034590227  171 qEDSLLVVSVAGELKVWDLSS 191
Cdd:cd00200    189 -GEKLLSSSSDGTIKLWDLST 208
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-595 1.28e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.69  E-value: 1.28e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEGGSLVKdspphkVLKGHHQSVTSLLYPHglssklDQSWML 483
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLR------TLKGHTGPVRDVAASA------DGTYLA 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  484 SGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMI 563
Cdd:cd00200     68 SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1034590227  564 KWHPVENFLIVGCADDSVYIWEIETG----TLERHE 595
Cdd:cd00200    142 AFSPDGTFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 COG2319
WD40 repeat [General function prediction only];
419-602 6.80e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 6.80e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  419 LICGCEDGTIiitqalnaakaRL--LEGGSLVKdspphkVLKGHHQSVTSLLYphglSSklDQSWMLSGDLDSCVILWDI 496
Cdd:COG2319    219 LASGSADGTV-----------RLwdLATGKLLR------TLTGHSGSVRSVAF----SP--DGRLLASGSADGTVRLWDL 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  497 FTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGC 576
Cdd:COG2319    276 ATGELLRTLTGHSGGVNSVAFSPD-----GKLLASG-SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                          170       180
                   ....*....|....*....|....*.
gi 1034590227  577 ADDSVYIWEIETGTLERHETGERARI 602
Cdd:COG2319    350 DDGTVRLWDLATGELLRTLTGHTGAV 375
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-191 3.19e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 3.19e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   13 QKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLararDFS-KQPYIVSAAENGEMCV 91
Cdd:cd00200     47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKV 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   92 WNVTNGQCmeKATLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLIIDAKTLAVVHSFRSSQfpDWINCMCIVHSmri 170
Cdd:cd00200    120 WDVETGKC--LTTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHT--GEVNSVAFSPD--- 188

                          170       180
                   ....*....|....*....|.
gi 1034590227  171 qEDSLLVVSVAGELKVWDLSS 191
Cdd:cd00200    189 -GEKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 1.63e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 1.63e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227    3 TSLQAVALWGQKAPPHSITaimITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLArardFSkqP-- 78
Cdd:COG2319    109 TGLLLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA----FS--Pdg 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   79 -YIVSAAENGEMCVWNVTNGQCMekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPd 157
Cdd:COG2319    175 kLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGS- 248

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1034590227  158 wincmciVHSMRIQEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319    249 -------VRSVAFSPDGRLLASGSadGTVRLWDLAT 277
WD40 pfam00400
WD domain, G-beta repeat;
453-495 7.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 7.27e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034590227  453 PHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWD 495
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-595 1.28e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.69  E-value: 1.28e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEGGSLVKdspphkVLKGHHQSVTSLLYPHglssklDQSWML 483
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWD---------LETGELLR------TLKGHTGPVRDVAASA------DGTYLA 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  484 SGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMI 563
Cdd:cd00200     68 SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1034590227  564 KWHPVENFLIVGCADDSVYIWEIETG----TLERHE 595
Cdd:cd00200    142 AFSPDGTFVASSSQDGTIKLWDLRTGkcvaTLTGHT 177
WD40 COG2319
WD40 repeat [General function prediction only];
419-602 6.80e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 6.80e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  419 LICGCEDGTIiitqalnaakaRL--LEGGSLVKdspphkVLKGHHQSVTSLLYphglSSklDQSWMLSGDLDSCVILWDI 496
Cdd:COG2319    219 LASGSADGTV-----------RLwdLATGKLLR------TLTGHSGSVRSVAF----SP--DGRLLASGSADGTVRLWDL 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  497 FTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGC 576
Cdd:COG2319    276 ATGELLRTLTGHSGGVNSVAFSPD-----GKLLASG-SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                          170       180
                   ....*....|....*....|....*.
gi 1034590227  577 ADDSVYIWEIETGTLERHETGERARI 602
Cdd:COG2319    350 DDGTVRLWDLATGELLRTLTGHTGAV 375
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 412-595 2.29e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 2.29e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  412 YIPSLDKLICGCEDGTIIITQalnaakarlleggslVKDSPPHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCV 491
Cdd:cd00200     59 ASADGTYLASGSSDKTIRLWD---------------LETGECVRTLTGHTSYVSSVAFSP------DGRILSSSSRDKTI 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  492 ILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENF 571
Cdd:cd00200    118 KVWDVETGKCLTTLRGHTDWVNSVAFSPDG------TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK 191

                          170       180
                   ....*....|....*....|....*...
gi 1034590227  572 LIVGCADDSVYIWEIETG----TLERHE 595
Cdd:cd00200    192 LLSSSSDGTIKLWDLSTGkclgTLRGHE 219
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-191 3.19e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 3.19e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   13 QKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLararDFS-KQPYIVSAAENGEMCV 91
Cdd:cd00200     47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSV----AFSpDGRILSSSSRDKTIKV 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   92 WNVTNGQCmeKATLPYrHTAICyYHCSFrmTGEGWLLCCGEY-QDVLIIDAKTLAVVHSFRSSQfpDWINCMCIVHSmri 170
Cdd:cd00200    120 WDVETGKC--LTTLRG-HTDWV-NSVAF--SPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHT--GEVNSVAFSPD--- 188

                          170       180
                   ....*....|....*....|.
gi 1034590227  171 qEDSLLVVSVAGELKVWDLSS 191
Cdd:cd00200    189 -GEKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
419-602 4.53e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 4.53e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  419 LICGCEDGTIIItqaLNAAKARLLeggslvkdspphKVLKGHHQSVTSLLY-PHGlsskldqSWMLSGDLDSCVILWDIF 497
Cdd:COG2319    177 LASGSDDGTVRL---WDLATGKLL------------RTLTGHTGAVRSVAFsPDG-------KLLASGSADGTVRLWDLA 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  498 TEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCA 577
Cdd:COG2319    235 TGKLLRTLTGHSGSVRSVAFSPD-----GRLLASG-SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                          170       180
                   ....*....|....*....|....*
gi 1034590227  578 DDSVYIWEIETGTLERHETGERARI 602
Cdd:COG2319    309 DGTVRLWDLATGKLLRTLTGHTGAV 333
WD40 COG2319
WD40 repeat [General function prediction only];
3-191 1.63e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 1.63e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227    3 TSLQAVALWGQKAPPHSITaimITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLArardFSkqP-- 78
Cdd:COG2319    109 TGLLLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLA-----TGKLLrtLTGHSGAVTSVA----FS--Pdg 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   79 -YIVSAAENGEMCVWNVTNGQCMekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPd 157
Cdd:COG2319    175 kLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGS- 248

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1034590227  158 wincmciVHSMRIQEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319    249 -------VRSVAFSPDGRLLASGSadGTVRLWDLAT 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 385-597 3.19e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.43  E-value: 3.19e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  385 DTMSQSIIDYFSGLKDGagtavVTSSEYIPSlDKLICGC-EDGTIIITQalnaakarlleggslVKDSPPHKVLKGHHQS 463
Cdd:cd00200     79 DLETGECVRTLTGHTSY-----VSSVAFSPD-GRILSSSsRDKTIKVWD---------------VETGKCLTTLRGHTDW 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  464 VTSLLYPHglssklDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLH 543
Cdd:cd00200    138 VNSVAFSP------DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-----GEKLLSS-SSDGTIKLWD 205

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034590227  544 LEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETG----TLERHETG 597
Cdd:cd00200    206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGecvqTLSGHTNS 263
WD40 COG2319
WD40 repeat [General function prediction only];
403-602 3.21e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.47  E-value: 3.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  403 GTAVVTSSEYIPSLDKLICGCEDGTIiitqalnaakaRLLEggslVKDSPPHKVLKGHHQSVTSLLYphglSSklDQSWM 482
Cdd:COG2319     77 HTAAVLSVAFSPDGRLLASASADGTV-----------RLWD----LATGLLLRTLTGHTGAVRSVAF----SP--DGKTL 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  483 LSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICcVCGDHSVALLHLEGKSCLLHARKHLFPVRM 562
Cdd:COG2319    136 ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-----GKLLAS-GSDDGTVRLWDLATGKLLRTLTGHTGAVRS 209

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1034590227  563 IKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI 602
Cdd:COG2319    210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249
WD40 COG2319
WD40 repeat [General function prediction only];
419-588 2.96e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 2.96e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  419 LICGCEDGTIiitqalnaakaRL--LEGGSLVKdspphkVLKGHHQSVTSLLY-PHGlsskldqSWMLSGDLDSCVILWD 495
Cdd:COG2319    261 LASGSADGTV-----------RLwdLATGELLR------TLTGHSGGVNSVAFsPDG-------KLLASGSDDGTVRLWD 316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  496 IFTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICCvCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVG 575
Cdd:COG2319    317 LATGKLLRTLTGHTGAVRSVAFSPD-----GKTLASG-SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390

                          170
                   ....*....|...
gi 1034590227  576 CADDSVYIWEIET 588
Cdd:COG2319    391 SADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
14-191 1.40e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 1.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   14 KAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISakeLLFGHSASVTCLArardFSkqP---YIVSAAENGEMC 90
Cdd:COG2319    243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR---TLTGHSGGVNSVA----FS--PdgkLLASGSDDGTVR 313

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   91 VWNVTNGQCMekATLPYRHTAIcyYHCSFRMTGEgWLLCCGEYQDVLIIDAKTLAVVHSFRssQFPDWincmciVHSMRI 170
Cdd:COG2319    314 LWDLATGKLL--RTLTGHTGAV--RSVAFSPDGK-TLASGSDDGTVRLWDLATGELLRTLT--GHTGA------VTSVAF 380

                          170       180
                   ....*....|....*....|...
gi 1034590227  171 QEDSLLVVSVA--GELKVWDLSS 191
Cdd:COG2319    381 SPDGRTLASGSadGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
456-602 2.19e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 2.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  456 VLKGHHQSVTSLLYPhglsskLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEkfklrGEQIICcVCG 535
Cdd:COG2319     73 TLLGHTAAVLSVAFS------PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD-----GKTLAS-GSA 140

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034590227  536 DHSVALLHLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI 602
Cdd:COG2319    141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 404-585 8.87e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 8.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  404 TAVVTSSEYIPSLDKLICGCEDGTIIITQalnaakarlLEGGSLVKdspphkVLKGHHQSVTSL-LYPhglssklDQSWM 482
Cdd:cd00200    135 TDWVNSVAFSPDGTFVASSSQDGTIKLWD---------LRTGKCVA------TLTGHTGEVNSVaFSP-------DGEKL 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  483 LSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKfklrgeQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRM 562
Cdd:cd00200    193 LSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTS 266

                          170       180
                   ....*....|....*....|...
gi 1034590227  563 IKWHPVENFLIVGCADDSVYIWE 585
Cdd:cd00200    267 LAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
18-191 3.20e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 3.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   18 HSITAIMITDDQRTIVTGSQEGQLCLWNLSHELkisAKELLFGHSASVTCLARARDfskQPYIVSAAENGEMCVWNVTNG 97
Cdd:COG2319     79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFSPD---GKTLASGSADGTVRLWDLATG 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   98 QCMekATLPyRHTAICYyhcSFRMTGEG-WLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPdwincmciVHSMRIQEDSLL 176
Cdd:COG2319    153 KLL--RTLT-GHSGAVT---SVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGA--------VRSVAFSPDGKL 218

                          170
                   ....*....|....*..
gi 1034590227  177 VVSVA--GELKVWDLSS 191
Cdd:COG2319    219 LASGSadGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-191 1.56e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 1.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   58 LFGHSASVTCLArardFS-KQPYIVSAAENGEMCVWNVTNGQCMEKATLpyrHTaICYYHCSFRMTGEgWLLCCGEYQDV 136
Cdd:cd00200      5 LKGHTGGVTCVA----FSpDGKLLATGSGDGTIKVWDLETGELLRTLKG---HT-GPVRDVAASADGT-YLASGSSDKTI 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034590227  137 LIIDAKTLAVVHSFRssQFPDWINCMCIVHSMRIqedsLLVVSVAGELKVWDLSS 191
Cdd:cd00200     76 RLWDLETGECVRTLT--GHTSYVSSVAFSPDGRI----LSSSSRDKTIKVWDVET 124
WD40 COG2319
WD40 repeat [General function prediction only];
473-602 7.13e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 7.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  473 LSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPekfklrGEQIICCVCGDHSVALLHLEGKSCLLH 552
Cdd:COG2319     42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP------DGRLLASASADGTVRLWDLATGLLLRT 115

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034590227  553 ARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI 602
Cdd:COG2319    116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-114 1.19e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 1.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   19 SITAIMITDDQRTIVTGSQEGQLCLWNLShelKISAKELLFGHSASVTCLArardFSKQPYIV-SAAENGEMCVWNVTNG 97
Cdd:cd00200    179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKCLGTLRGHENGVNSVA----FSPDGYLLaSGSEDGTIRVWDLRTG 251

                           90
                   ....*....|....*..
gi 1034590227   98 QCMekATLPyRHTAICY 114
Cdd:cd00200    252 ECV--QTLS-GHTNSVT 265
WD40 COG2319
WD40 repeat [General function prediction only];
10-96 8.21e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 8.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227   10 LWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLShelkiSAKEL--LFGHSASVTCLARARDfskQPYIVSAAENG 87
Cdd:COG2319    323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA-----TGELLrtLTGHTGAVTSVAFSPD---GRTLASGSADG 394


                   ....*....
gi 1034590227   88 EMCVWNVTN 96
Cdd:COG2319    395 TVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 556-613 1.55e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 1.55e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034590227  556 HLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI--ILNCCDDSQLV 613
Cdd:cd00200      8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVrdVAASADGTYLA 67
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-93 3.78e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 3.78e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034590227   19 SITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAkelLFGHSASVTCLArardFSKQ-PYIVSAAENGEMCVWN 93
Cdd:cd00200    221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---LSGHTNSVTSLA----WSPDgKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
453-495 7.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 7.27e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034590227  453 PHKVLKGHHQSVTSLLYPHglssklDQSWMLSGDLDSCVILWD 495
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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