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Conserved domains on  [gi|1034588225|ref|XP_016877154|]
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iron-sulfur cluster transfer protein NUBPL isoform X4 [Homo sapiens]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 65-171 2.20e-43

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam10609:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 246  Bit Score: 144.52  E-value: 2.20e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588225  65 GVKQVIVVASGKGGVGKSTTAVNLALALAANDssKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSM 144
Cdd:pfam10609   1 GVKHVIAVASGKGGVGKSTVAVNLALALARLG--YKVGLLDADIYGPSIPRMLGLEGERPEQSDGGIIPVEAHGIKVMSI 78

                          90       100
                  ....*....|....*....|....*...
gi 1034588225 145 GFLVE-ESEPVVWRGLMVMSAIEKLLRQ 171
Cdd:pfam10609  79 GFLLPdEDDAVIWRGPMKSGAIKQFLTD 106
 
Name Accession Description Interval E-value
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 65-171 2.20e-43

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 144.52  E-value: 2.20e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588225  65 GVKQVIVVASGKGGVGKSTTAVNLALALAANDssKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSM 144
Cdd:pfam10609   1 GVKHVIAVASGKGGVGKSTVAVNLALALARLG--YKVGLLDADIYGPSIPRMLGLEGERPEQSDGGIIPVEAHGIKVMSI 78

                          90       100
                  ....*....|....*....|....*...
gi 1034588225 145 GFLVE-ESEPVVWRGLMVMSAIEKLLRQ 171
Cdd:pfam10609  79 GFLLPdEDDAVIWRGPMKSGAIKQFLTD 106
Mrp_NBP35 cd02037
Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically ...
 69-171 5.75e-39

Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.


Pssm-ID: 349757 [Multi-domain]  Cd Length: 213  Bit Score: 132.24  E-value: 5.75e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588225  69 VIVVASGKGGVGKSTTAVNLALALAANDssKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLV 148
Cdd:cd02037     2 IIAVLSGKGGVGKSTVAVNLALALAKKG--YKVGLLDADIYGPSIPRLLGVEGKPLHQSEEGIVPVEVGGIKVMSIGFLL 79

                          90       100
                  ....*....|....*....|...
gi 1034588225 149 EESEPVVWRGLMVMSAIEKLLRQ 171
Cdd:cd02037    80 PEDDAVIWRGPMKSGAIKQFLKD 102
PRK11670 PRK11670
iron-sulfur cluster carrier protein ApbC;
60-169 1.49e-25

iron-sulfur cluster carrier protein ApbC;


Pssm-ID: 183270 [Multi-domain]  Cd Length: 369  Bit Score: 100.89  E-value: 1.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588225  60 QKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSkaIGLLDVDVYGPSVPKMMNLKGNPELSQSNL-MRPLLNYG 138
Cdd:PRK11670  100 QPGVNGVKNIIAVSSGKGGVGKSSTAVNLALALAAEGAK--VGILDADIYGPSIPTMLGAEDQRPTSPDGThMAPIMAHG 177

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1034588225 139 IACMSMGFLVEESEPVVWRGLMVMSAIEKLL 169
Cdd:PRK11670  178 LATNSIGYLVTDDNAMVWRGPMASKALMQML 208
Mrp COG0489
Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, ...
 68-171 3.19e-17

Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440255 [Multi-domain]  Cd Length: 289  Bit Score: 77.15  E-value: 3.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588225  68 QVIVVASGKGGVGKSTTAVNLALALAANDSSkaIGLLDVDVYGPSVPKMMNLKGNPELSQ--------SNLMRPLLNYGI 139
Cdd:COG0489    93 EVIAVTSGKGGEGKSTVAANLALALAQSGKR--VLLIDADLRGPSLHRMLGLENRPGLSDvlageaslEDVIQPTEVEGL 170

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1034588225 140 ACMSMGFLVEESEpvvwrGLMVMSAIEKLLRQ 171
Cdd:COG0489   171 DVLPAGPLPPNPS-----ELLASKRLKQLLEE 197
minD_bact TIGR01968
septum site-determining protein MinD; This model describes the bacterial and chloroplast form ...
 69-108 8.64e-04

septum site-determining protein MinD; This model describes the bacterial and chloroplast form of MinD, a multifunctional cell division protein that guides correct placement of the septum. The homologous archaeal MinD proteins, with many archaeal genomes having two or more forms, are described by a separate model. [Cellular processes, Cell division]


Pssm-ID: 131023 [Multi-domain]  Cd Length: 261  Bit Score: 38.86  E-value: 8.64e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034588225  69 VIVVASGKGGVGKSTTAVNLALALAAndSSKAIGLLDVDV 108
Cdd:TIGR01968   3 VIVITSGKGGVGKTTTTANLGTALAR--LGKKVVLIDADI 40
 
Name Accession Description Interval E-value
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 65-171 2.20e-43

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 144.52  E-value: 2.20e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588225  65 GVKQVIVVASGKGGVGKSTTAVNLALALAANDssKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSM 144
Cdd:pfam10609   1 GVKHVIAVASGKGGVGKSTVAVNLALALARLG--YKVGLLDADIYGPSIPRMLGLEGERPEQSDGGIIPVEAHGIKVMSI 78

                          90       100
                  ....*....|....*....|....*...
gi 1034588225 145 GFLVE-ESEPVVWRGLMVMSAIEKLLRQ 171
Cdd:pfam10609  79 GFLLPdEDDAVIWRGPMKSGAIKQFLTD 106
Mrp_NBP35 cd02037
Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically ...
 69-171 5.75e-39

Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.


Pssm-ID: 349757 [Multi-domain]  Cd Length: 213  Bit Score: 132.24  E-value: 5.75e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588225  69 VIVVASGKGGVGKSTTAVNLALALAANDssKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLV 148
Cdd:cd02037     2 IIAVLSGKGGVGKSTVAVNLALALAKKG--YKVGLLDADIYGPSIPRLLGVEGKPLHQSEEGIVPVEVGGIKVMSIGFLL 79

                          90       100
                  ....*....|....*....|...
gi 1034588225 149 EESEPVVWRGLMVMSAIEKLLRQ 171
Cdd:cd02037    80 PEDDAVIWRGPMKSGAIKQFLKD 102
PRK11670 PRK11670
iron-sulfur cluster carrier protein ApbC;
60-169 1.49e-25

iron-sulfur cluster carrier protein ApbC;


Pssm-ID: 183270 [Multi-domain]  Cd Length: 369  Bit Score: 100.89  E-value: 1.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588225  60 QKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSkaIGLLDVDVYGPSVPKMMNLKGNPELSQSNL-MRPLLNYG 138
Cdd:PRK11670  100 QPGVNGVKNIIAVSSGKGGVGKSSTAVNLALALAAEGAK--VGILDADIYGPSIPTMLGAEDQRPTSPDGThMAPIMAHG 177

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1034588225 139 IACMSMGFLVEESEPVVWRGLMVMSAIEKLL 169
Cdd:PRK11670  178 LATNSIGYLVTDDNAMVWRGPMASKALMQML 208
Mrp COG0489
Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, ...
 68-171 3.19e-17

Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440255 [Multi-domain]  Cd Length: 289  Bit Score: 77.15  E-value: 3.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034588225  68 QVIVVASGKGGVGKSTTAVNLALALAANDSSkaIGLLDVDVYGPSVPKMMNLKGNPELSQ--------SNLMRPLLNYGI 139
Cdd:COG0489    93 EVIAVTSGKGGEGKSTVAANLALALAQSGKR--VLLIDADLRGPSLHRMLGLENRPGLSDvlageaslEDVIQPTEVEGL 170

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1034588225 140 ACMSMGFLVEESEpvvwrGLMVMSAIEKLLRQ 171
Cdd:COG0489   171 DVLPAGPLPPNPS-----ELLASKRLKQLLEE 197
ParAB_family cd02042
partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved ...
 69-87 5.64e-06

partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single-stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis. ParA shares sequence similarity to a conserved and widespread family of ATPases which includes the repA protein of the repABC operon in Rhizobium etli symbiotic plasmid. This operon is involved in the plasmid replication and partition.


Pssm-ID: 349760 [Multi-domain]  Cd Length: 130  Bit Score: 43.68  E-value: 5.64e-06
                          10
                  ....*....|....*....
gi 1034588225  69 VIVVASGKGGVGKSTTAVN 87
Cdd:cd02042     2 VIAVANQKGGVGKTTLAVN 20
ParA COG1192
ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein ...
 68-87 7.97e-06

ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein BcsQ [Cell cycle control, cell division, chromosome partitioning, Cell motility];


Pssm-ID: 440805 [Multi-domain]  Cd Length: 253  Bit Score: 44.85  E-value: 7.97e-06
                          10        20
                  ....*....|....*....|
gi 1034588225  68 QVIVVASGKGGVGKSTTAVN 87
Cdd:COG1192     2 KVIAVANQKGGVGKTTTAVN 21
MinD COG2894
Septum site-determining ATPase MinD [Cell cycle control, cell division, chromosome ...
 68-87 2.25e-05

Septum site-determining ATPase MinD [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442139 [Multi-domain]  Cd Length: 258  Bit Score: 43.51  E-value: 2.25e-05
                          10        20
                  ....*....|....*....|
gi 1034588225  68 QVIVVASGKGGVGKSTTAVN 87
Cdd:COG2894     3 KVIVVTSGKGGVGKTTTTAN 22
CpaE COG4963
Flp pilus assembly ATPase CpaE/TadZ, contains N-terminal REC/TadZ_N domain [Intracellular ...
 68-123 3.41e-05

Flp pilus assembly ATPase CpaE/TadZ, contains N-terminal REC/TadZ_N domain [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443989 [Multi-domain]  Cd Length: 358  Bit Score: 43.18  E-value: 3.41e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034588225  68 QVIVVASGKGGVGKSTTAVNLALALAANDSSKAIgLLDVDVYGPSVPKMMNLKGNP 123
Cdd:COG4963   103 RVIAVVGAKGGVGATTLAVNLAWALARESGRRVL-LVDLDLQFGDVALYLDLEPRR 157
MinD cd02036
septum site-determining protein MinD; Septum site-determining protein MinD is part of the ...
 69-87 1.27e-04

septum site-determining protein MinD; Septum site-determining protein MinD is part of the operon MinCDE that determines the site of the formation of a septum at mid-cell, an important part of bacterial cell division. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal role, selecting the mid-cell over other sites through the activation and regulation of MinC and MinE. MinD is a membrane-associated ATPase, related to nitrogenase iron protein.


Pssm-ID: 349756 [Multi-domain]  Cd Length: 236  Bit Score: 41.03  E-value: 1.27e-04
                          10
                  ....*....|....*....
gi 1034588225  69 VIVVASGKGGVGKSTTAVN 87
Cdd:cd02036     2 VIVITSGKGGVGKTTTTAN 20
CbiA pfam01656
CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid ...
 70-87 3.12e-04

CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA and CbiP from S.typhimurium, and CobQ from R. capsulatus. These amidases catalyze amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria. The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family.


Pssm-ID: 426369 [Multi-domain]  Cd Length: 228  Bit Score: 40.02  E-value: 3.12e-04
                          10
                  ....*....|....*...
gi 1034588225  70 IVVASGKGGVGKSTTAVN 87
Cdd:pfam01656   1 IAIAGTKGGVGKTTLAAN 18
AAA_31 pfam13614
AAA domain; This family includes a wide variety of AAA domains including some that have lost ...
 68-87 3.84e-04

AAA domain; This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.


Pssm-ID: 433350 [Multi-domain]  Cd Length: 177  Bit Score: 39.49  E-value: 3.84e-04
                          10        20
                  ....*....|....*....|
gi 1034588225  68 QVIVVASGKGGVGKSTTAVN 87
Cdd:pfam13614   2 KVIAIANQKGGVGKTTTSVN 21
minD CHL00175
septum-site determining protein; Validated
 57-87 5.86e-04

septum-site determining protein; Validated


Pssm-ID: 214385 [Multi-domain]  Cd Length: 281  Bit Score: 39.37  E-value: 5.86e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1034588225  57 LPKQKPIEGVKQVIVVASGKGGVGKSTTAVN 87
Cdd:CHL00175    5 TEDKEKSATMSRIIVITSGKGGVGKTTTTAN 35
minD_bact TIGR01968
septum site-determining protein MinD; This model describes the bacterial and chloroplast form ...
 69-108 8.64e-04

septum site-determining protein MinD; This model describes the bacterial and chloroplast form of MinD, a multifunctional cell division protein that guides correct placement of the septum. The homologous archaeal MinD proteins, with many archaeal genomes having two or more forms, are described by a separate model. [Cellular processes, Cell division]


Pssm-ID: 131023 [Multi-domain]  Cd Length: 261  Bit Score: 38.86  E-value: 8.64e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034588225  69 VIVVASGKGGVGKSTTAVNLALALAAndSSKAIGLLDVDV 108
Cdd:TIGR01968   3 VIVITSGKGGVGKTTTTANLGTALAR--LGKKVVLIDADI 40
FlhG-like cd02038
MinD-like ATPase FlhG; FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) ...
 68-87 1.76e-03

MinD-like ATPase FlhG; FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) is a major determinant for a variety of flagellation patterns. It effects location and number of bacterial flagella during C-ring assembly.


Pssm-ID: 349758 [Multi-domain]  Cd Length: 230  Bit Score: 37.93  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|
gi 1034588225  68 QVIVVASGKGGVGKSTTAVN 87
Cdd:cd02038     1 RIIAVTSGKGGVGKTNVSAN 20
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
 70-124 2.23e-03

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 37.36  E-value: 2.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034588225  70 IVVASGKGGVGKSTTAVNLALalaandSSKAIGLLDVDVYGPSVPKMMNLKGNPE 124
Cdd:cd03110     2 IAVLSGKGGTGKTTITANLAV------LLYNVILVDCDVDAPNLHLLLGPEPEEE 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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