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Conserved domains on  [gi|1034576288|ref|XP_016874047|]
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centromere/kinetochore protein zw10 homolog isoform X1 [Homo sapiens]

Protein Classification

centromere/kinetochore protein zw10( domain architecture ID 10533349)

centromere/kinetochore protein zw10 ensures proper chromosome segregation during cell division

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Zw10 pfam06248
Centromere/kinetochore Zw10; Zw10 and rough deal proteins are both required for correct ...
27-488 0e+00

Centromere/kinetochore Zw10; Zw10 and rough deal proteins are both required for correct metaphase check-pointing during mitosis. These proteins bind to the centromere/kinetochore.


:

Pssm-ID: 461861  Cd Length: 509  Bit Score: 604.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288  27 LTRRVEEIKGEVCNMISKKYSEFLPSMQSAQGLITQVDKLSEDIDLLKSRIESEVRRDLHVSTGEFTDLKQQLERDSVVL 106
Cdd:pfam06248   1 LERKVEEIKEEVSNMIVKKYSEFLPNMSSTQELIDQVSSLSREISDLLECVENEVLADLNGSVEELAELKQQLRECENVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 107 SLLKQLQEFSTAIEEYNCALTEKKYVTGAQRLEEAQKCLKLLKSRKCFDLKILKSLSMELTIQKQNILYHLGEEWQKLIV 186
Cdd:pfam06248  81 DLLQSLLKIDEALEEYNEALKNKDYLVAANLLEELRQCLDGLKERKGQDVKILKALSSELTVQSENLIYHLGEEWDRLIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 187 WKFPPSKDTSSLESYLQTELHLYTEQSHKeektPMPPISSVLLAFSVLGELHSKLKSFDLPL------------------ 248
Cdd:pfam06248 161 WKFPPSKDLGGDKSFLSTALNLSTEESQK----NGALLSEVLQALAVIGELPEKLKLFGQSLiknvirplivhpslgvdv 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 249 -----------------DTDLENEKTSTV-----------------------------PLAEMLGDMIWEDLSECLIKNC 282
Cdd:pfam06248 237 esvqnpegaqlrlessqKTKGEKVDPSQVyskvlevlkvlcshlldvslksqedaggkSVSEILGDLIWPRLSELIIKDC 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 283 LVYSIPTNSSKLQQYEEIIQSTEEFENALKEMRFLKGDTTDLLKYARNINSHFANKKCQDVIVAARNLMTSEIHNTVKII 362
Cdd:pfam06248 317 LVKSIPETSSKLEDYQELIEQTEDFEEALKELGFLSGDSTDLLKYAEDVNTHFANRKCQDVLVKARKLMTSDIHNTVKVT 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 363 PDSKINVPElptpdednklevqKVSNTQYHEVMNLEPENTLDQHSFSLPTCRISESVKKLMELAYQTLLEATTSSDQCAV 442
Cdd:pfam06248 397 PDSKAHIPA-------------ELEAKEYSERLWSENEKTLSPLTFSFPRCRVSESAQQLMNLAYQTLKEATTSSDECAV 463
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1034576288 443 QLFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAIHHNNCMYIAHHL 488
Cdd:pfam06248 464 QLFYTVRNIFQLYYDVVPTYHKENLLSLPQLAAIFHNNCMYIAHHL 509
 
Name Accession Description Interval E-value
Zw10 pfam06248
Centromere/kinetochore Zw10; Zw10 and rough deal proteins are both required for correct ...
27-488 0e+00

Centromere/kinetochore Zw10; Zw10 and rough deal proteins are both required for correct metaphase check-pointing during mitosis. These proteins bind to the centromere/kinetochore.


Pssm-ID: 461861  Cd Length: 509  Bit Score: 604.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288  27 LTRRVEEIKGEVCNMISKKYSEFLPSMQSAQGLITQVDKLSEDIDLLKSRIESEVRRDLHVSTGEFTDLKQQLERDSVVL 106
Cdd:pfam06248   1 LERKVEEIKEEVSNMIVKKYSEFLPNMSSTQELIDQVSSLSREISDLLECVENEVLADLNGSVEELAELKQQLRECENVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 107 SLLKQLQEFSTAIEEYNCALTEKKYVTGAQRLEEAQKCLKLLKSRKCFDLKILKSLSMELTIQKQNILYHLGEEWQKLIV 186
Cdd:pfam06248  81 DLLQSLLKIDEALEEYNEALKNKDYLVAANLLEELRQCLDGLKERKGQDVKILKALSSELTVQSENLIYHLGEEWDRLIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 187 WKFPPSKDTSSLESYLQTELHLYTEQSHKeektPMPPISSVLLAFSVLGELHSKLKSFDLPL------------------ 248
Cdd:pfam06248 161 WKFPPSKDLGGDKSFLSTALNLSTEESQK----NGALLSEVLQALAVIGELPEKLKLFGQSLiknvirplivhpslgvdv 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 249 -----------------DTDLENEKTSTV-----------------------------PLAEMLGDMIWEDLSECLIKNC 282
Cdd:pfam06248 237 esvqnpegaqlrlessqKTKGEKVDPSQVyskvlevlkvlcshlldvslksqedaggkSVSEILGDLIWPRLSELIIKDC 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 283 LVYSIPTNSSKLQQYEEIIQSTEEFENALKEMRFLKGDTTDLLKYARNINSHFANKKCQDVIVAARNLMTSEIHNTVKII 362
Cdd:pfam06248 317 LVKSIPETSSKLEDYQELIEQTEDFEEALKELGFLSGDSTDLLKYAEDVNTHFANRKCQDVLVKARKLMTSDIHNTVKVT 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 363 PDSKINVPElptpdednklevqKVSNTQYHEVMNLEPENTLDQHSFSLPTCRISESVKKLMELAYQTLLEATTSSDQCAV 442
Cdd:pfam06248 397 PDSKAHIPA-------------ELEAKEYSERLWSENEKTLSPLTFSFPRCRVSESAQQLMNLAYQTLKEATTSSDECAV 463
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1034576288 443 QLFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAIHHNNCMYIAHHL 488
Cdd:pfam06248 464 QLFYTVRNIFQLYYDVVPTYHKENLLSLPQLAAIFHNNCMYIAHHL 509
 
Name Accession Description Interval E-value
Zw10 pfam06248
Centromere/kinetochore Zw10; Zw10 and rough deal proteins are both required for correct ...
27-488 0e+00

Centromere/kinetochore Zw10; Zw10 and rough deal proteins are both required for correct metaphase check-pointing during mitosis. These proteins bind to the centromere/kinetochore.


Pssm-ID: 461861  Cd Length: 509  Bit Score: 604.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288  27 LTRRVEEIKGEVCNMISKKYSEFLPSMQSAQGLITQVDKLSEDIDLLKSRIESEVRRDLHVSTGEFTDLKQQLERDSVVL 106
Cdd:pfam06248   1 LERKVEEIKEEVSNMIVKKYSEFLPNMSSTQELIDQVSSLSREISDLLECVENEVLADLNGSVEELAELKQQLRECENVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 107 SLLKQLQEFSTAIEEYNCALTEKKYVTGAQRLEEAQKCLKLLKSRKCFDLKILKSLSMELTIQKQNILYHLGEEWQKLIV 186
Cdd:pfam06248  81 DLLQSLLKIDEALEEYNEALKNKDYLVAANLLEELRQCLDGLKERKGQDVKILKALSSELTVQSENLIYHLGEEWDRLIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 187 WKFPPSKDTSSLESYLQTELHLYTEQSHKeektPMPPISSVLLAFSVLGELHSKLKSFDLPL------------------ 248
Cdd:pfam06248 161 WKFPPSKDLGGDKSFLSTALNLSTEESQK----NGALLSEVLQALAVIGELPEKLKLFGQSLiknvirplivhpslgvdv 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 249 -----------------DTDLENEKTSTV-----------------------------PLAEMLGDMIWEDLSECLIKNC 282
Cdd:pfam06248 237 esvqnpegaqlrlessqKTKGEKVDPSQVyskvlevlkvlcshlldvslksqedaggkSVSEILGDLIWPRLSELIIKDC 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 283 LVYSIPTNSSKLQQYEEIIQSTEEFENALKEMRFLKGDTTDLLKYARNINSHFANKKCQDVIVAARNLMTSEIHNTVKII 362
Cdd:pfam06248 317 LVKSIPETSSKLEDYQELIEQTEDFEEALKELGFLSGDSTDLLKYAEDVNTHFANRKCQDVLVKARKLMTSDIHNTVKVT 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034576288 363 PDSKINVPElptpdednklevqKVSNTQYHEVMNLEPENTLDQHSFSLPTCRISESVKKLMELAYQTLLEATTSSDQCAV 442
Cdd:pfam06248 397 PDSKAHIPA-------------ELEAKEYSERLWSENEKTLSPLTFSFPRCRVSESAQQLMNLAYQTLKEATTSSDECAV 463
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1034576288 443 QLFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAIHHNNCMYIAHHL 488
Cdd:pfam06248 464 QLFYTVRNIFQLYYDVVPTYHKENLLSLPQLAAIFHNNCMYIAHHL 509
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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