NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034671481|ref|XP_016870667|]
View 

zinc finger protein 484 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
389-790 2.38e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 2.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 389 KPYVCTECGKAFIRKSHFITHERIHTGEKPYECSD--CGKSFIKKSQLHVHQRIHTGENPFICSECGKVFTHKTN-LIIH 465
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASsSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 466 QKIHTGERPYICTVCGKAFTDRSNLIKHQKIHTGEKPYKCSDCGKSFTW-KSRLRIHQKCHTGERHYECSECGKAFIQKS 544
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 545 TLSMHQRIHrgekpyvCTECGKAFFHKSHFITHERIHTGEKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAF 624
Cdd:COG5048   192 VSTSIPSSS-------ENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 625 TDRSNLFTHQKIHTGE-------KPYKCSDCGKAFTRKSGLHIHQQS--HTGERHYECSE----CGKAFARKSTLIMHQR 691
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 692 IHTGEKPYIC--NECGKSFIQKSHLNRH-----RRIHTGEKPYECSDCGKSFIKKS----QLHEHHRIHTGEKPYICAEC 760
Cdd:COG5048   345 LHTSISPAKEklLNSSSKFSPLLNNEPPqslqqYKDLKNDKKSETLSNSCIRNFKRdsnlSLHIITHLSFRPYNCKNPPC 424

                         410       420       430
                  ....*....|....*....|....*....|
gi 1034671481 761 GKAFTIRSNLIKHQKIHTKQKPYKCSDLGK 790
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
KRAB super family cl42959
krueppel associated box;
1-31 2.83e-09

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 53.75  E-value: 2.83e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034671481    1 MLENYFNLISVGCQVPKPEVIFSLEQ-EEPCM 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQgEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-374 6.12e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034671481 349 NLNIHKKIHTGGKHFECTECGKAFTR 374
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
389-790 2.38e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 2.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 389 KPYVCTECGKAFIRKSHFITHERIHTGEKPYECSD--CGKSFIKKSQLHVHQRIHTGENPFICSECGKVFTHKTN-LIIH 465
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASsSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 466 QKIHTGERPYICTVCGKAFTDRSNLIKHQKIHTGEKPYKCSDCGKSFTW-KSRLRIHQKCHTGERHYECSECGKAFIQKS 544
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 545 TLSMHQRIHrgekpyvCTECGKAFFHKSHFITHERIHTGEKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAF 624
Cdd:COG5048   192 VSTSIPSSS-------ENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 625 TDRSNLFTHQKIHTGE-------KPYKCSDCGKAFTRKSGLHIHQQS--HTGERHYECSE----CGKAFARKSTLIMHQR 691
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 692 IHTGEKPYIC--NECGKSFIQKSHLNRH-----RRIHTGEKPYECSDCGKSFIKKS----QLHEHHRIHTGEKPYICAEC 760
Cdd:COG5048   345 LHTSISPAKEklLNSSSKFSPLLNNEPPqslqqYKDLKNDKKSETLSNSCIRNFKRdsnlSLHIITHLSFRPYNCKNPPC 424

                         410       420       430
                  ....*....|....*....|....*....|
gi 1034671481 761 GKAFTIRSNLIKHQKIHTKQKPYKCSDLGK 790
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
KRAB smart00349
krueppel associated box;
1-31 2.83e-09

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 53.75  E-value: 2.83e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034671481    1 MLENYFNLISVGCQVPKPEVIFSLEQ-EEPCM 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQgEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
713-736 2.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.17e-04
                          10        20
                  ....*....|....*....|....
gi 1034671481 713 HLNRHRRIHTGEKPYECSDCGKSF 736
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 613-665 1.15e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 1.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034671481 613 KPYrCAECGKAFTDRSNLFTHQKIHTgekpYKCSDCGKAFTRKSGLHIH-QQSH 665
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-374 6.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034671481 349 NLNIHKKIHTGGKHFECTECGKAFTR 374
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
389-790 2.38e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 2.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 389 KPYVCTECGKAFIRKSHFITHERIHTGEKPYECSD--CGKSFIKKSQLHVHQRIHTGENPFICSECGKVFTHKTN-LIIH 465
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASsSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 466 QKIHTGERPYICTVCGKAFTDRSNLIKHQKIHTGEKPYKCSDCGKSFTW-KSRLRIHQKCHTGERHYECSECGKAFIQKS 544
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 545 TLSMHQRIHrgekpyvCTECGKAFFHKSHFITHERIHTGEKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAF 624
Cdd:COG5048   192 VSTSIPSSS-------ENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 625 TDRSNLFTHQKIHTGE-------KPYKCSDCGKAFTRKSGLHIHQQS--HTGERHYECSE----CGKAFARKSTLIMHQR 691
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 692 IHTGEKPYIC--NECGKSFIQKSHLNRH-----RRIHTGEKPYECSDCGKSFIKKS----QLHEHHRIHTGEKPYICAEC 760
Cdd:COG5048   345 LHTSISPAKEklLNSSSKFSPLLNNEPPqslqqYKDLKNDKKSETLSNSCIRNFKRdsnlSLHIITHLSFRPYNCKNPPC 424

                         410       420       430
                  ....*....|....*....|....*....|
gi 1034671481 761 GKAFTIRSNLIKHQKIHTKQKPYKCSDLGK 790
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
445-818 6.15e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 6.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 445 NPFICSECGKVFTHKTNLIIHQKIHTGERPYICTV--CGKAFTDRSNLIKHQKIHTGEKPYKCSD-CGKSFTWKSRLRIH 521
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 522 QKCHTGERHYECSECGKAFIQK---------STLSMHQRIHRGEKPYVCTEC-------------GKAFFHKSHFITHER 579
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRdpqlpdllsISNLRNNPLPGNNSSSVNTPQsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 580 IHTGEKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAFTD------RSNLFTHQKIHTGEKPYKCSDCGKAFT 653
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 654 RKSGLHIHQQSHTGERH-YECSECGKAFARKSTLIMHQR--IHTGE--KPYICNE--CGKSFIQKSHLNRHRRIHTGEKP 726
Cdd:COG5048   272 SSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 727 YEC--SDCGKSFIKKS-----QLHEHHRIHTGEKPYICA--ECGKAFTIRSNLIKHQKIHTKQKPYKCSDLGKALNWKPQ 797
Cdd:COG5048   352 AKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         410       420
                  ....*....|....*....|..
gi 1034671481 798 LSM-PQKSDNGEVECSMPQLWC 818
Cdd:COG5048   432 YNLiPHKKIHTNHAPLLCSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
333-717 1.88e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 333 KPYEYSECEKNLPQNSNLNIHKKIHTGGKHFECT--ECGKAFTRKSTLSMHQKIHTGEKPYVCT-ECGKAFIRKSHFITH 409
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 410 ERIHTGEKPYECSDCGKSFIKKSQLH------------VHQRIHTGENPFICS----------ECGKVFTHKTNLIIHQK 467
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdllsisnlrnnPLPGNNSSSVNTPQSnslhpplpanSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 468 IHTGERPYICTVCGKAFTDRSNLIKHQKIHTGEKPYKCSDCGKSFTWKSRLRIHQKCHTGERHYECSECGKAFIQKSTLS 547
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 548 MHQRIHRGE-------KPYVCTECGKAFFHKSHFITHER--IHTGE--KPYEC--SICGKSFTKKSQLHVHQQIHTGEKP 614
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 615 YRC--AECGKAFTDRSN-----LFTHQKIHTGEKPYKCSD--CGKAFTRKSGLHIHQQSHTGERHYEC--SECGKAFARK 683
Cdd:COG5048   352 AKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1034671481 684 STLIMHQRIHTgEKPYICNECGKSFIQKSHLNRH 717
Cdd:COG5048   432 YNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
KRAB smart00349
krueppel associated box;
1-31 2.83e-09

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 53.75  E-value: 2.83e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034671481    1 MLENYFNLISVGCQVPKPEVIFSLEQ-EEPCM 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQgEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
474-663 1.01e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 474 PYICTVCGKAFTDRSNLIKHQ--KIHTGE--KPYKC--SDCGKSFTWKSRLRIHQKCHTGERHYEC--SECGKAFIQKST 545
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 546 LSMHQRIHrgekpyvctecgkaffhksHFITHERIHTGEKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAFT 625
Cdd:COG5048   369 NEPPQSLQ-------------------QYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFN 429

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1034671481 626 DRSNLFTHQKIHTGEKPYKCSDCGKAFTRKSGLHIHQQ 663
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
713-736 2.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.17e-04
                          10        20
                  ....*....|....*....|....
gi 1034671481 713 HLNRHRRIHTGEKPYECSDCGKSF 736
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
629-654 4.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 1034671481 629 NLFTHQKIHTGEKPYKCSDCGKAFTR 654
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
489-513 5.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.20e-04
                          10        20
                  ....*....|....*....|....*
gi 1034671481 489 NLIKHQKIHTGEKPYKCSDCGKSFT 513
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 613-665 1.15e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 1.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034671481 613 KPYrCAECGKAFTDRSNLFTHQKIHTgekpYKCSDCGKAFTRKSGLHIH-QQSH 665
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-402 1.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.56e-03
                          10        20
                  ....*....|....*....|....*
gi 1034671481 378 LSMHQKIHTGEKPYVCTECGKAFIR 402
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 639-718 1.68e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 639 GEKPYKCS--DCGKAFTRKSGLHIHQQshtgERHyecseCGKAFARKSTLIMHQRIHTGEKPYICNECGKSFIQKSHLNR 716
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML----HGH-----QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1034671481 717 HR 718
Cdd:COG5189   417 HR 418
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 699-721 1.77e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.77e-03
                          10        20
                  ....*....|....*....|...
gi 1034671481 699 YICNECGKSFIQKSHLNRHRRIH 721
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
573-598 3.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034671481 573 HFITHERIHTGEKPYECSICGKSFTK 598
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
546-568 4.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.34e-03
                          10        20
                  ....*....|....*....|...
gi 1034671481 546 LSMHQRIHRGEKPYVCTECGKAF 568
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 583-666 4.50e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 4.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671481 583 GEKPYECSI--CGKSFT-----KKSQLHVHQQIHTGEKPYrcaecgkafTDRSNLFTHQkihtgEKPYKCSDCGKAFTRK 655
Cdd:COG5189   346 DGKPYKCPVegCNKKYKnqnglKYHMLHGHQNQKLHENPS---------PEKMNIFSAK-----DKPYRCEVCDKRYKNL 411

                          90
                  ....*....|.
gi 1034671481 656 SGLHIHQQSHT 666
Cdd:COG5189   412 NGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
405-428 4.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.65e-03
                          10        20
                  ....*....|....*....|....
gi 1034671481 405 HFITHERIHTGEKPYECSDCGKSF 428
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-374 6.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034671481 349 NLNIHKKIHTGGKHFECTECGKAFTR 374
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 475-497 6.52e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.52e-03
                          10        20
                  ....*....|....*....|...
gi 1034671481 475 YICTVCGKAFTDRSNLIKHQKIH 497
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 419-441 9.19e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.19e-03
                          10        20
                  ....*....|....*....|...
gi 1034671481 419 YECSDCGKSFIKKSQLHVHQRIH 441
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH