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Conserved domains on  [gi|1034664100|ref|XP_016869856|]
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sarcosine dehydrogenase, mitochondrial isoform X2 [Homo sapiens]

Protein Classification

FAD-dependent oxidoreductase( domain architecture ID 11429831)

FAD-dependent oxidoreductase containing a GcvT (glycine cleavage system T) domain such as sarcosine dehydrogenase and dimethylglycine dehydrogenase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 480-871 9.06e-102

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


:

Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 320.87  E-value: 9.06e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 480 GRNMRRDPLHEELLGQGCVFQERHGWERPGWFHprgpapvleydyygaygsrahedyayrrlladeytfafpphhDTIKK 559
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP------------------------------------------GGVIA 38

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 560 ECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPshqasplapa 638
Cdd:COG0404    39 EHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGE---------- 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 639 fegDGYYLAMGGAVAQHNWSHITTVLQDQKSqCQLIDSSEDLGMISIQGPASRAILQEVLDADLSneAFPFSTHKLLRAA 718
Cdd:COG0404   109 ---DRFLLVVNAANAAKDLAWLEEHLPPDFD-VTITDVTDDWALLAVQGPKAREVLAKLTDADLS--ALPFMSFREGTVA 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 719 GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:COG0404   183 GVPVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWA 262

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034664100 799 CKLKSPvPFLGREALEQQRAAGLRRRLVCFTMEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIH 871
Cdd:COG0404   263 VKLDKG-DFIGKEALLRQKEEGPRRKLVGLELDGRGVPRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVP 334
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
66-444 3.65e-84

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


:

Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 274.09  E-value: 3.65e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100  66 TANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVS--RELEEETGL 143
Cdd:COG0665     2 TADVVVIGGGIAGLSTAYHLARRGLD-VTVLERGRPGSGASGRNAGQLRPGLAALADRALVRLAREALDlwRELAAELGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 144 HTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARA 223
Cdd:COG0665    81 DCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALARA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 224 ASARGAQVIENCPVTGIRVwTDDfgvrRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:COG0665   161 ARAAGVRIREGTPVTGLER-EGG----RVTGVRTERGTVRADAVVLAAGAWSARLLPMLGLRLPLRPVRGYVLVTEPLPD 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 304 IQNMPNVRDHDasVYLRLQGD-ALSVGGyeanpifweevSDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCG 382
Cdd:COG0665   236 LPLRPVLDDTG--VYLRPTADgRLLVGG-----------TAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWAG 302

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034664100 383 PESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRR 444
Cdd:COG0665   303 LRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 430-485 2.94e-21

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


:

Pssm-ID: 465100  Cd Length: 56  Bit Score: 87.51  E-value: 2.94e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034664100 430 HGRPEKDMHGYDIRRFHHsLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRR 485
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGP-HQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRT 55
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 480-871 9.06e-102

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 320.87  E-value: 9.06e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 480 GRNMRRDPLHEELLGQGCVFQERHGWERPGWFHprgpapvleydyygaygsrahedyayrrlladeytfafpphhDTIKK 559
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP------------------------------------------GGVIA 38

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 560 ECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPshqasplapa 638
Cdd:COG0404    39 EHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGE---------- 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 639 fegDGYYLAMGGAVAQHNWSHITTVLQDQKSqCQLIDSSEDLGMISIQGPASRAILQEVLDADLSneAFPFSTHKLLRAA 718
Cdd:COG0404   109 ---DRFLLVVNAANAAKDLAWLEEHLPPDFD-VTITDVTDDWALLAVQGPKAREVLAKLTDADLS--ALPFMSFREGTVA 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 719 GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:COG0404   183 GVPVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWA 262

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034664100 799 CKLKSPvPFLGREALEQQRAAGLRRRLVCFTMEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIH 871
Cdd:COG0404   263 VKLDKG-DFIGKEALLRQKEEGPRRKLVGLELDGRGVPRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVP 334
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
66-444 3.65e-84

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 274.09  E-value: 3.65e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100  66 TANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVS--RELEEETGL 143
Cdd:COG0665     2 TADVVVIGGGIAGLSTAYHLARRGLD-VTVLERGRPGSGASGRNAGQLRPGLAALADRALVRLAREALDlwRELAAELGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 144 HTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARA 223
Cdd:COG0665    81 DCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALARA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 224 ASARGAQVIENCPVTGIRVwTDDfgvrRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:COG0665   161 ARAAGVRIREGTPVTGLER-EGG----RVTGVRTERGTVRADAVVLAAGAWSARLLPMLGLRLPLRPVRGYVLVTEPLPD 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 304 IQNMPNVRDHDasVYLRLQGD-ALSVGGyeanpifweevSDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCG 382
Cdd:COG0665   236 LPLRPVLDDTG--VYLRPTADgRLLVGG-----------TAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWAG 302

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034664100 383 PESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRR 444
Cdd:COG0665   303 LRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 489-798 6.54e-67

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 223.62  E-value: 6.54e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 489 HEELLGQGCVFQERHGWERPGWFHPRGpapvleydyygaygsrahedyayrrlladeytfafpphhdtIKKECLACRGAA 568
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNG-----------------------------------------ILAEHRAVREAA 39

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 569 AVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPSHqasplapafegdgYYLA 647
Cdd:pfam01571  40 GLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKlKPGRATYTLMLNERGGVIDDLTVYRLGDDH-------------FLLV 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 648 MGGAVAQHNWSHITTVLQdqKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLsNEAFPFSTHKLLRAAGHLVRAMRL 727
Cdd:pfam01571 107 VNAANREKDLAWLRKHAE--KLDVVVVDVTDDYALLALQGPKAREVLEKLTDGDL-LEALPFFSFREIEIGGVPVRVSRT 183

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034664100 728 SFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:pfam01571 184 GYTGEDGFEIYVPAEDAVELWEALLEAGAELGLRPAGLGARDSLRLEAGLPLYGHDLDEETTPLEAGLGWA 254
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 69-427 1.21e-59

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 206.87  E-value: 1.21e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100  69 VVVIGGGSLGCQTLYHLAKLGMSgAVLLERE-RLTSGTTWHTAGLLWQLR---PSDVEVELLAHTRRVVsRELEEETGLH 144
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGLS-VTLLERGdDPGSGASGRNAGLIHPGLrylEPSELARLALEALDLW-EELEEELGID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 145 TGWIQNGGLFIASNrQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLmnVDDLYGTLYVPHDGTMDPAGTCTTLARAA 224
Cdd:pfam01266  80 CGFRRCGVLVLARD-EEEEALEKLLAALRRLGVPAELLDAEELRELEPL--LPGLRGGLFYPDGGHVDPARLLRALARAA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 225 SARGAQVIENCPVTGIRVWTDDFGVRrvagvetQHGSIQtpCVVNCAGVWASAVgRMAGVKVPLVAMHHAYVVTERIEGI 304
Cdd:pfam01266 157 EALGVRIIEGTEVTGIEEEGGVWGVV-------TTGEAD--AVVNAAGAWADLL-ALPGLRLPVRPVRGQVLVLEPLPEA 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 305 QN---MPNVRDHDASVYLRLQGD-ALSVGGYEanpifweevsDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKtgIKSTV 380
Cdd:pfam01266 227 LLilpVPITVDPGRGVYLRPRADgRLLLGGTD----------EEDGFDDPTPDPEEIEELLEAARRLFPALAD--IERAW 294

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1034664100 381 CGPESfTPDHKPLMGEaPELRGFFLGCGFNSAGMMLGGGCGQELAHW 427
Cdd:pfam01266 295 AGLRP-LPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
551-852 5.77e-50

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 180.31  E-value: 5.77e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 551 PPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPs 629
Cdd:PRK00389   27 PVQYGSIIEEHHAVRTDAGLFDVSHMGEVDVTGPDALAFLQYLLANDVSKlKPGKAQYTCMLNEDGGVIDDLIVYKLSE- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 630 hqasplapafegDGYYLAMGGAVAQHNWSHITTVLQDQKsqCQLIDSSEDLGMISIQGPASRAILQEVLDADLSnEAFPF 709
Cdd:PRK00389  106 ------------DEYLLVVNAANREKDLAWIKSHAAGFG--VEVTDRSDDLAMIAVQGPKAREKLQKLTDADLS-ELKPF 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 710 STHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKH-GLInagyrAIDSLSIEKGYR-HWHaDLRPD 787
Cdd:PRK00389  171 FGAQGAEVGGGDVLVARTGYTGEDGFEIYLPAEDAEALWDALLEAGVKPcGLG-----ARDTLRLEAGMPlYGQ-DMDET 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034664100 788 DSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVCFTMEDK-VPMFGLEaIWRNGQVVGHV 852
Cdd:PRK00389  245 ITPLEAGLGWTVKLEEKRDFIGREALEAQKEAGVERKLVGLELEERgIPRHGYP-VLADGEEIGEV 309
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 430-485 2.94e-21

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 87.51  E-value: 2.94e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034664100 430 HGRPEKDMHGYDIRRFHHsLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRR 485
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGP-HQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRT 55
glpA PRK11101
anaerobic glycerol-3-phosphate dehydrogenase subunit A;
64-286 1.76e-16

anaerobic glycerol-3-phosphate dehydrogenase subunit A;


Pssm-ID: 236847 [Multi-domain]  Cd Length: 546  Bit Score: 83.53  E-value: 1.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100  64 PSTANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLL-----WQLRPSDVEVELLAHTR--RVVSRE 136
Cdd:PRK11101    4 SQETDVIIIGGGATGAGIARDCALRGLR-CILVERHDIATGATGRNHGLLhsgarYAVTDAESARECISENQilKRIARH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 137 LEEETGlhtgwiqngGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNvDDLYGTLYVPhDGTMDPAGT 216
Cdd:PRK11101   83 CVEPTD---------GLFITLPEDDLAFQATFIRACEEAGIEAEAIDPQQALILEPAVN-PALIGAVKVP-DGTVDPFRL 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034664100 217 CTTLARAASARGAQVIENCPVTG-IRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKV 286
Cdd:PRK11101  152 TAANMLDAKEHGAQILTYHEVTGlIREGDTVCGVRVRDHLTGETQEIHAPVVVNAAGIWGQHIAEYADLRI 222
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 68-445 6.47e-13

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 71.40  E-value: 6.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100  68 NVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERL--TSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVSrELEEETG--L 143
Cdd:TIGR01377   2 DVIVVGAGIMGCFAAYHLAKHGKK-TLLLEQFDLphSRGSSHGQSRIIRKAYPEDFYTPMMLECYQLWA-QLEKEAGtkL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 144 HTgwiQNGGLFIASNRQRldEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARA 223
Cdd:TIGR01377  80 HR---QTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQEL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 224 ASARGAQVIENCPVTGIRVWTDdfgvrrVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:TIGR01377 155 AEAHGATVRDGTKVVEIEPTEL------LVTVKTTKGSYQANKLVVTAGAWTSKLLSPLGIEIPLQPLRINVCYWREKEP 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 304 -----IQNMPNVRDHDASVYL----RLQGDALSV----GGYEANP--IFWEevsdkfaFGLFDLDWEVFTQHIEgaiNRV 368
Cdd:TIGR01377 229 gsygvSQAFPCFLVLGLNPHIyglpSFEYPGLMKvyyhHGQQIDPdeRDCP-------FGADIEDVQILRKFVR---DHL 298

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034664100 369 PVLEKTGIKSTVCgPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRF 445
Cdd:TIGR01377 299 PGLNGEPKKGEVC-MYTNTPDEHFVIDLHPKYDNVVIGAGFSGHGFKLAPVVGKILAELAMKLKPSYDLAIFSLNRF 374
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 480-871 9.06e-102

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 320.87  E-value: 9.06e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 480 GRNMRRDPLHEELLGQGCVFQERHGWERPGWFHprgpapvleydyygaygsrahedyayrrlladeytfafpphhDTIKK 559
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP------------------------------------------GGVIA 38

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 560 ECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPshqasplapa 638
Cdd:COG0404    39 EHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGE---------- 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 639 fegDGYYLAMGGAVAQHNWSHITTVLQDQKSqCQLIDSSEDLGMISIQGPASRAILQEVLDADLSneAFPFSTHKLLRAA 718
Cdd:COG0404   109 ---DRFLLVVNAANAAKDLAWLEEHLPPDFD-VTITDVTDDWALLAVQGPKAREVLAKLTDADLS--ALPFMSFREGTVA 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 719 GHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:COG0404   183 GVPVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWA 262

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034664100 799 CKLKSPvPFLGREALEQQRAAGLRRRLVCFTMEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIH 871
Cdd:COG0404   263 VKLDKG-DFIGKEALLRQKEEGPRRKLVGLELDGRGVPRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVP 334
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
66-444 3.65e-84

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 274.09  E-value: 3.65e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100  66 TANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVS--RELEEETGL 143
Cdd:COG0665     2 TADVVVIGGGIAGLSTAYHLARRGLD-VTVLERGRPGSGASGRNAGQLRPGLAALADRALVRLAREALDlwRELAAELGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 144 HTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARA 223
Cdd:COG0665    81 DCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALARA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 224 ASARGAQVIENCPVTGIRVwTDDfgvrRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:COG0665   161 ARAAGVRIREGTPVTGLER-EGG----RVTGVRTERGTVRADAVVLAAGAWSARLLPMLGLRLPLRPVRGYVLVTEPLPD 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 304 IQNMPNVRDHDasVYLRLQGD-ALSVGGyeanpifweevSDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCG 382
Cdd:COG0665   236 LPLRPVLDDTG--VYLRPTADgRLLVGG-----------TAEPAGFDRAPTPERLEALLRRLRRLFPALADAEIVRAWAG 302

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034664100 383 PESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRR 444
Cdd:COG0665   303 LRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 489-798 6.54e-67

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 223.62  E-value: 6.54e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 489 HEELLGQGCVFQERHGWERPGWFHPRGpapvleydyygaygsrahedyayrrlladeytfafpphhdtIKKECLACRGAA 568
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNG-----------------------------------------ILAEHRAVREAA 39

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 569 AVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPSHqasplapafegdgYYLA 647
Cdd:pfam01571  40 GLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKlKPGRATYTLMLNERGGVIDDLTVYRLGDDH-------------FLLV 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 648 MGGAVAQHNWSHITTVLQdqKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLsNEAFPFSTHKLLRAAGHLVRAMRL 727
Cdd:pfam01571 107 VNAANREKDLAWLRKHAE--KLDVVVVDVTDDYALLALQGPKAREVLEKLTDGDL-LEALPFFSFREIEIGGVPVRVSRT 183

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034664100 728 SFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFT 798
Cdd:pfam01571 184 GYTGEDGFEIYVPAEDAVELWEALLEAGAELGLRPAGLGARDSLRLEAGLPLYGHDLDEETTPLEAGLGWA 254
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 69-427 1.21e-59

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 206.87  E-value: 1.21e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100  69 VVVIGGGSLGCQTLYHLAKLGMSgAVLLERE-RLTSGTTWHTAGLLWQLR---PSDVEVELLAHTRRVVsRELEEETGLH 144
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGLS-VTLLERGdDPGSGASGRNAGLIHPGLrylEPSELARLALEALDLW-EELEEELGID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 145 TGWIQNGGLFIASNrQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLmnVDDLYGTLYVPHDGTMDPAGTCTTLARAA 224
Cdd:pfam01266  80 CGFRRCGVLVLARD-EEEEALEKLLAALRRLGVPAELLDAEELRELEPL--LPGLRGGLFYPDGGHVDPARLLRALARAA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 225 SARGAQVIENCPVTGIRVWTDDFGVRrvagvetQHGSIQtpCVVNCAGVWASAVgRMAGVKVPLVAMHHAYVVTERIEGI 304
Cdd:pfam01266 157 EALGVRIIEGTEVTGIEEEGGVWGVV-------TTGEAD--AVVNAAGAWADLL-ALPGLRLPVRPVRGQVLVLEPLPEA 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 305 QN---MPNVRDHDASVYLRLQGD-ALSVGGYEanpifweevsDKFAFGLFDLDWEVFTQHIEGAINRVPVLEKtgIKSTV 380
Cdd:pfam01266 227 LLilpVPITVDPGRGVYLRPRADgRLLLGGTD----------EEDGFDDPTPDPEEIEELLEAARRLFPALAD--IERAW 294

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1034664100 381 CGPESfTPDHKPLMGEaPELRGFFLGCGFNSAGMMLGGGCGQELAHW 427
Cdd:pfam01266 295 AGLRP-LPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
551-852 5.77e-50

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 180.31  E-value: 5.77e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 551 PPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCMLNHRGGTESDLTVSRLAPs 629
Cdd:PRK00389   27 PVQYGSIIEEHHAVRTDAGLFDVSHMGEVDVTGPDALAFLQYLLANDVSKlKPGKAQYTCMLNEDGGVIDDLIVYKLSE- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 630 hqasplapafegDGYYLAMGGAVAQHNWSHITTVLQDQKsqCQLIDSSEDLGMISIQGPASRAILQEVLDADLSnEAFPF 709
Cdd:PRK00389  106 ------------DEYLLVVNAANREKDLAWIKSHAAGFG--VEVTDRSDDLAMIAVQGPKAREKLQKLTDADLS-ELKPF 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 710 STHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKH-GLInagyrAIDSLSIEKGYR-HWHaDLRPD 787
Cdd:PRK00389  171 FGAQGAEVGGGDVLVARTGYTGEDGFEIYLPAEDAEALWDALLEAGVKPcGLG-----ARDTLRLEAGMPlYGQ-DMDET 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034664100 788 DSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVCFTMEDK-VPMFGLEaIWRNGQVVGHV 852
Cdd:PRK00389  245 ITPLEAGLGWTVKLEEKRDFIGREALEAQKEAGVERKLVGLELEERgIPRHGYP-VLADGEEIGEV 309
PLN02319 PLN02319
aminomethyltransferase
 555-870 2.67e-25

aminomethyltransferase


Pssm-ID: 177953 [Multi-domain]  Cd Length: 404  Bit Score: 109.43  E-value: 2.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 555 DTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADV-SRPPGSTVYTCMLNHRGGTESDLTVSRLapshqas 633
Cdd:PLN02319   62 DSIMDSTLNCRQNGSLFDVSHMCGLSLKGKDAIPFLETLVVADIaGLKDGTGTLSVFTNEKGGIIDDTVITKV------- 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 634 plapafEGDGYYLAMGGAVAQHNWSHITTVLQDQKSQCQliDSSE----DLGMISIQGPASRAILQEVLDADLSneAFPF 709
Cdd:PLN02319  135 ------TDDHIYLVVNAGCRDKDLAHIEEHMKAFKAKGG--DVSWhvhdERSLLALQGPLAAPVLQHLTKEDLS--KMYF 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 710 STHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAagAKHGLIN-AGYRAIDSLSIEKGYRHWHADLRPDD 788
Cdd:PLN02319  205 GDFRITDINGADCFLTRTGYTGEDGFEISVPSEHAVDLAKALLE--KSEGKVRlTGLGARDSLRLEAGLCLYGNDLEEHI 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 789 SPLEAGLAFTC--KLKSPVPFLGREALEQQRAAGLRRRLVCFTMEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIA 866
Cdd:PLN02319  283 TPVEAGLAWTIgkRRRAEGGFLGADVILKQLKEGVSRRRVGFISSGAPARSHSEILDESGEKIGEVTSGGFSPCLKKNIA 362


                  ....
gi 1034664100 867 YGYI 870
Cdd:PLN02319  363 MGYV 366
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 430-485 2.94e-21

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 87.51  E-value: 2.94e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034664100 430 HGRPEKDMHGYDIRRFHHsLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRR 485
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGP-HQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRT 55
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
69-284 4.48e-19

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 90.59  E-value: 4.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100  69 VVVIGGGSLGCQTLYHLAKLgmSGA--VLLERE-RLTSGTTWHTAGLLwqlrpsdvevellaHT-----------RRVVS 134
Cdd:COG0579     7 VVIIGAGIVGLALARELSRY--EDLkvLVLEKEdDVAQESSGNNSGVI--------------HAglyytpgslkaRLCVE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 135 -----RELEEETGLhtGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVES-HVLSPAETKTLYPLMNVDDLYGtLYVPHD 208
Cdd:COG0579    71 gnelfYELCRELGI--PFKRCGKLVVATGEEEVAFLEKLYERGKANGVPGlEILDREELRELEPLLSDEGVAA-LYSPST 147

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034664100 209 GTMDPAGTCTTLARAASARGAQVIENCPVTGIRVWTDDFGVrrvagvETQHGSIQTPCVVNCAGVWASAVGRMAGV 284
Cdd:COG0579   148 GIVDPGALTRALAENAEANGVELLLNTEVTGIEREGDGWEV------TTNGGTIRARFVINAAGLYADRLAQMAGI 217
glpA PRK11101
anaerobic glycerol-3-phosphate dehydrogenase subunit A;
64-286 1.76e-16

anaerobic glycerol-3-phosphate dehydrogenase subunit A;


Pssm-ID: 236847 [Multi-domain]  Cd Length: 546  Bit Score: 83.53  E-value: 1.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100  64 PSTANVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERLTSGTTWHTAGLL-----WQLRPSDVEVELLAHTR--RVVSRE 136
Cdd:PRK11101    4 SQETDVIIIGGGATGAGIARDCALRGLR-CILVERHDIATGATGRNHGLLhsgarYAVTDAESARECISENQilKRIARH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 137 LEEETGlhtgwiqngGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNvDDLYGTLYVPhDGTMDPAGT 216
Cdd:PRK11101   83 CVEPTD---------GLFITLPEDDLAFQATFIRACEEAGIEAEAIDPQQALILEPAVN-PALIGAVKVP-DGTVDPFRL 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034664100 217 CTTLARAASARGAQVIENCPVTG-IRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKV 286
Cdd:PRK11101  152 TAANMLDAKEHGAQILTYHEVTGlIREGDTVCGVRVRDHLTGETQEIHAPVVVNAAGIWGQHIAEYADLRI 222
GCV_T_C pfam08669
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage ...
 823-872 1.68e-13

Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 462554 [Multi-domain]  Cd Length: 80  Bit Score: 66.35  E-value: 1.68e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034664100 823 RRLVCFTMED-KVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHD 872
Cdd:pfam08669   1 RRLVGLELDDgDPLLRGGEPVLRDGEVVGYVTSGAYSPTLGKSIALAYVDA 51
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 68-445 6.47e-13

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 71.40  E-value: 6.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100  68 NVVVIGGGSLGCQTLYHLAKLGMSgAVLLERERL--TSGTTWHTAGLLWQLRPSDVEVELLAHTRRVVSrELEEETG--L 143
Cdd:TIGR01377   2 DVIVVGAGIMGCFAAYHLAKHGKK-TLLLEQFDLphSRGSSHGQSRIIRKAYPEDFYTPMMLECYQLWA-QLEKEAGtkL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 144 HTgwiQNGGLFIASNRQRldEYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARA 223
Cdd:TIGR01377  80 HR---QTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQEL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 224 ASARGAQVIENCPVTGIRVWTDdfgvrrVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTERIEG 303
Cdd:TIGR01377 155 AEAHGATVRDGTKVVEIEPTEL------LVTVKTTKGSYQANKLVVTAGAWTSKLLSPLGIEIPLQPLRINVCYWREKEP 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 304 -----IQNMPNVRDHDASVYL----RLQGDALSV----GGYEANP--IFWEevsdkfaFGLFDLDWEVFTQHIEgaiNRV 368
Cdd:TIGR01377 229 gsygvSQAFPCFLVLGLNPHIyglpSFEYPGLMKvyyhHGQQIDPdeRDCP-------FGADIEDVQILRKFVR---DHL 298

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034664100 369 PVLEKTGIKSTVCgPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRF 445
Cdd:TIGR01377 299 PGLNGEPKKGEVC-MYTNTPDEHFVIDLHPKYDNVVIGAGFSGHGFKLAPVVGKILAELAMKLKPSYDLAIFSLNRF 374
PRK00711 PRK00711
D-amino acid dehydrogenase;
126-288 4.64e-12

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 69.06  E-value: 4.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 126 LAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYP-LMNV-DDLYGTL 203
Cdd:PRK00711  111 LAEYSRDCLKALRAETGIQYEGRQGGTLQLFRTQQQLDAAAKDIAVLEEAGVPYELLDRDELAAVEPaLAGVrHKLVGGL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 204 YVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIRVWTDdfgvrRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAG 283
Cdd:PRK00711  191 RLPNDETGDCQLFTQRLAAMAEQLGVKFRFNTPVDGLLVEGG-----RITGVQTGGGVITADAYVVALGSYSTALLKPLG 265


                  ....*
gi 1034664100 284 VKVPL 288
Cdd:PRK00711  266 VDIPV 270
PRK12409 PRK12409
D-amino acid dehydrogenase small subunit; Provisional
 68-286 3.98e-11

D-amino acid dehydrogenase small subunit; Provisional


Pssm-ID: 237093 [Multi-domain]  Cd Length: 410  Bit Score: 65.81  E-value: 3.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100  68 NVVVIGGGSLGCQTLYHLAKLGMSGAVLlERERL----TS-----------------------GTTWHT---AGLLWQLR 117
Cdd:PRK12409    3 HIAVIGAGITGVTTAYALAQRGYQVTVF-DRHRYaameTSfanggqlsasnaevwnhwatvlkGLKWMLrkdAPLLLNPK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 118 PS----DVEVELLAHTRR------------VVSRE----LEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGV 177
Cdd:PRK12409   82 PSwhkySWLAEFLAHIPNyrantietvrlaIAARKhlfdIAEREGIDFDLERRGILHIYHDKAGFDHAKRVNALLAEGGL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 178 ESHVLSPAETKTLYPLMNvDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIRVWTDDFGVRRVAGVET 257
Cdd:PRK12409  162 ERRAVTPEEMRAIEPTLT-GEYYGGYYTPSDSTGDIHKFTTGLAAACARLGVQFRYGQEVTSIKTDGGGVVLTVQPSAEH 240

                         250       260
                  ....*....|....*....|....*....
gi 1034664100 258 QHGSIQTPCVVNCAGVWASAVGRMAGVKV 286
Cdd:PRK12409  241 PSRTLEFDGVVVCAGVGSRALAAMLGDRV 269
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
151-286 5.91e-11

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 65.23  E-value: 5.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 151 GGLFIASNRQRLDEYKRLMSLGKAYGVESHVLSPAETKTLYPlmNVDDLyGTLYVPHDGTMDPAGTCTTLARAASARGAQ 230
Cdd:PRK11728   89 GKLLVATSELELERMEALYERARANGIEVERLDAEELREREP--NIRGL-GAIFVPSTGIVDYRAVAEAMAELIQARGGE 165

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034664100 231 VIENCPVTGIRvwTDDFGVRrvagVETQHGSIQTPCVVNCAGVWASAVGRMAGVKV 286
Cdd:PRK11728  166 IRLGAEVTALD--EHANGVV----VRTTQGEYEARTLINCAGLMSDRLAKMAGLEP 215
solA PRK11259
N-methyl-L-tryptophan oxidase;
69-276 1.54e-10

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 64.09  E-value: 1.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100  69 VVVIGGGSLGCQTLYHLAKLGMSgaVL-LER-------------ERLTsgttwhtagllwqlR------PSDVEVELLAH 128
Cdd:PRK11259    6 VIVIGLGSMGSAAGYYLARRGLR--VLgLDRfmpphqqgsshgdTRII--------------RhaygegPAYVPLVLRAQ 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 129 TrrvVSRELEEETG---LHtgwiQNGGLFIASNRQRLdeYKRLMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYV 205
Cdd:PRK11259   70 E---LWRELERESGeplFV----RTGVLNLGPADSDF--LANSIRSARQHGLPHEVLDAAEIRRRFPQFRLPDGYIALFE 140

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034664100 206 PHDGTMDPAGTCTTLARAASARGAQVIENCPVTGIRvwTDDFGVRrvagVETQHGSIQTPCVVNCAGVWAS 276
Cdd:PRK11259  141 PDGGFLRPELAIKAHLRLAREAGAELLFNEPVTAIE--ADGDGVT----VTTADGTYEAKKLVVSAGAWVK 205
GlpA COG0578
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 171-287 3.34e-10

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440343 [Multi-domain]  Cd Length: 501  Bit Score: 63.61  E-value: 3.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 171 LGKAYGVESH-VLSPAETKTLYPLMNVDDL-YGTLYvpHDGTMDPAGTCTTLARAASARGAQVIENCPVTGI-----RVW 243
Cdd:COG0578    93 LAGRKGLPRHrRLSRAEALALAPLLRPDGLrGGFEY--YDAQVDDARLVLELARTAAERGAVVLNYTRVTGLlrdggRVW 170

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1034664100 244 tddfGVRrVAGVET-QHGSIQTPCVVNCAGVWASAVGRMAGVKVP 287
Cdd:COG0578   171 ----GVT-VRDRLTgEEFTVRARVVVNATGPWVDELRALDGPKAP 210
dmdA PRK12486
dimethylsulfoniopropionate demethylase;
527-870 3.63e-08

dimethylsulfoniopropionate demethylase;


Pssm-ID: 237113 [Multi-domain]  Cd Length: 368  Bit Score: 56.30  E-value: 3.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 527 AYGSRAHEdyAYRRLLadeytfaFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGST 605
Cdd:PRK12486   22 AAGVKAYT--VYNHML-------LPTVFESVEDDYAHLKEHVQVWDVAVERQVEIRGPDAARLVQMLTPRDLRGmKPGQC 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 606 VYTCMLNHRGGTESDLTVSRLAPSHQASPLApafEGDGYYLAMGGAVAqhnwsHITTVLQDQKsqcqlidsseDLGMISI 685
Cdd:PRK12486   93 YYVPIVDETGGMLNDPVALKLAEDRWWISIA---DSDLLLWVKGLANG-----RKLDVLVVEP----------DVSPLAV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 686 QGPASRAILQEVLDADLSN------EAFPFSTHKLLRAaghlvramRLSFVGELGWELHIPKA-SCVPVYRAVMAAGAKH 758
Cdd:PRK12486  155 QGPKADALMARVFGEAIRDlrffrfGYFDFEGTDLVIA--------RSGYSKQGGFEIYVEGSdLGMPLWDALFEAGKDL 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 759 GLINAGYRAIDSlsIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVCFTME-DKVPMF 837
Cdd:PRK12486  227 NVRAGCPNLIER--IEGGLLSYGNDMTRDNTPHECGLGRFCNTQTDIGCIGKDALLRVAKEGPQKQIRGIKIGgERIPPC 304

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1034664100 838 GleAIWR---NGQVVGHVRRADFGFAIDKTIAYGYI 870
Cdd:PRK12486  305 D--RAWPllaGDNRVGQVTSAAYSPDFQTNVAIGMV 338
PLN02464 PLN02464
glycerol-3-phosphate dehydrogenase
 1-287 5.07e-04

glycerol-3-phosphate dehydrogenase


Pssm-ID: 215257 [Multi-domain]  Cd Length: 627  Bit Score: 43.62  E-value: 5.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100   1 MASLSRALRVAAA-----------HPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTlkegQGTSVVAQGPSRPLpstaNV 69
Cdd:PLN02464    3 LARLRRLAAGAAAtaaggavylspQPASSDKGGGPALDSLRDRIADPNASVPSRSA----QESALIGATAAEPL----DV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100  70 VVIGGGSLGCQTLYHLAKLGMSGAvLLERERLTSGTTWHTAGLLWQ-LRPSDVEV-ELLAHTRRVVSRELEEETGLhtgw 147
Cdd:PLN02464   75 LVVGGGATGAGVALDAATRGLRVG-LVEREDFSSGTSSRSTKLIHGgVRYLEKAVfQLDYGQLKLVFHALEERKQL---- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 148 IQNG-----GLFIASNRQRLDEYKRLMSLGKAY----GVESHVLS----PAETKTLYPLMNVDDLYGTL---YVPHDGTM 211
Cdd:PLN02464  150 IENAphlchALPIMTPCYDWFEVPYYWAGLKAYdlvaGPRLLHLSryysAKESLELFPTLAKKGKDGSLkgtVVYYDGQM 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664100 212 DPAGTCTTLARAASARGAQVIENCPVTGIrvwTDDFGVRRVAGVETQHG------SIQTPCVVNCAGVWASAVGRMAGVK 285
Cdd:PLN02464  230 NDSRLNVALACTAALAGAAVLNYAEVVSL---IKDESTGRIVGARVRDNltgkefDVYAKVVVNAAGPFCDEVRKMADGK 306


                  ..
gi 1034664100 286 VP 287
Cdd:PLN02464  307 AK 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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