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Conserved domains on  [gi|1034645090|ref|XP_016865008|]
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ribosomal protein uL24-like isoform X1 [Homo sapiens]

Protein Classification

uL24 family ribosomal protein( domain architecture ID 11246010)

uL24 family ribosomal protein is required for the assembly of different ribosomal subunits and are widely distributed among all living organisms.

Gene Ontology:  GO:0006412|GO:0003735|GO:0003723
PubMed:  24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L26 pfam16906
Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the ...
 8-122 8.27e-70

Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the 60S ribosomal proteins from eukaryotes - L26 - and archaea - L25.


:

Pssm-ID: 465307 [Multi-domain]  Cd Length: 114  Bit Score: 205.43  E-value: 8.27e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034645090   8 TSDRSKNRKRHFNAPSHVRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQiGKVVQVYRKKYVIYIERVQR 87
Cdd:pfam16906   1 SSSRRKQRKAHFNAPSHIRRKLMSAPLSKELREKYGVRSLPIRKGDEVKVVRGDFKGRE-GKVVQVYRKKYRIHVEGVTR 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034645090  88 EKANGTTVHVGIHPSKVVITRLKLDKDRKKILERK 122
Cdd:pfam16906  80 EKANGTTVPVPIHPSKVVITKLKLDKDRKKILERK 114
PRK05431 super family cl35319
seryl-tRNA synthetase; Provisional
 109-145 5.66e-03

seryl-tRNA synthetase; Provisional


The actual alignment was detected with superfamily member PRK05431:

Pssm-ID: 235461 [Multi-domain]  Cd Length: 425  Bit Score: 35.81  E-value: 5.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1034645090 109 LKLDKDRKKIL--------ERKAKSRQVG--KEKGKYKEELIEKMQE 145
Cdd:PRK05431   31 LELDEERRELQteleelqaERNALSKEIGqaKRKGEDAEALIAEVKE 77
 
Name Accession Description Interval E-value
Ribosomal_L26 pfam16906
Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the ...
 8-122 8.27e-70

Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the 60S ribosomal proteins from eukaryotes - L26 - and archaea - L25.


Pssm-ID: 465307 [Multi-domain]  Cd Length: 114  Bit Score: 205.43  E-value: 8.27e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034645090   8 TSDRSKNRKRHFNAPSHVRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQiGKVVQVYRKKYVIYIERVQR 87
Cdd:pfam16906   1 SSSRRKQRKAHFNAPSHIRRKLMSAPLSKELREKYGVRSLPIRKGDEVKVVRGDFKGRE-GKVVQVYRKKYRIHVEGVTR 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034645090  88 EKANGTTVHVGIHPSKVVITRLKLDKDRKKILERK 122
Cdd:pfam16906  80 EKANGTTVPVPIHPSKVVITKLKLDKDRKKILERK 114
PTZ00194 PTZ00194
60S ribosomal protein L26; Provisional
 3-137 1.71e-60

60S ribosomal protein L26; Provisional


Pssm-ID: 185508  Cd Length: 143  Bit Score: 183.03  E-value: 1.71e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034645090   3 FNPFVTSDRSKNRKRHFNAPSHVRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQiGKVVQVYRKKYVIYI 82
Cdd:PTZ00194    1 FNSIVSSSRRKARKAHFTAPSHLRRKLMSAPLSKELRAKYNVRSMPVRKDDEVMVVRGHHKGRE-GKVTAVYRKKWVIHI 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034645090  83 ERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSRQVGKEKGKYKE 137
Cdd:PTZ00194   80 EKITREKANGEPVQIGIHPSNVIITKLKLNKDRKAILERKARSTKSDKGKGKYTA 134
rplX_A_E TIGR01080
ribosomal protein uL24, archaeal/eukaryotic form; This model represents the archaeal and ...
 8-121 5.73e-44

ribosomal protein uL24, archaeal/eukaryotic form; This model represents the archaeal and eukaryotic branch of the ribosomal protein L24p/L26e family. Bacterial and organellar forms are represented by related model TIGR01079. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273432  Cd Length: 114  Bit Score: 140.37  E-value: 5.73e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034645090   8 TSDRSKNRKRHFNAPSHVRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQiGKVVQVYRKKYVIYIERVQR 87
Cdd:TIGR01080   1 SKQPRKQRKALFTAPLHERRKLMSAPLSKELREKYGKRALPIRKGDEVRIVRGDFKGHE-GKVSKVDRKRYRIYVEGVTK 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034645090  88 EKANGTTVHVGIHPSKVVITRLKLDKD-RKKILER 121
Cdd:TIGR01080  80 EKVDGTEVPVPLHPSNVMITKLHLDDEkRKKLLER 114
KOW_RPL26 cd06089
KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at ...
 52-106 6.04e-13

KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at their N terminal. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. RPL26 makes a very minor contributions to the biogenesis, structure, and function of 60s ribosomal subunits. However, RPL24 is essential to generate the first intermediate during 50s ribosomal subunits assembly. RPL26 have an extra-ribosomal function to enhances p53 translation after DNA damage.


Pssm-ID: 240513  Cd Length: 65  Bit Score: 59.84  E-value: 6.04e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034645090  52 DDEVQVVRGHYKGQQiGKVVQVYRKKYVIYIERVQREKAN-----------GTTVHVGIHPSKVVI 106
Cdd:cd06089     1 GDEVQVIRGKDKGKQ-GKVLKVDRKKNRVIVEGVNVVKKHvkpsqenpqggIIEVEAPIHISNVML 65
PRK05431 PRK05431
seryl-tRNA synthetase; Provisional
 109-145 5.66e-03

seryl-tRNA synthetase; Provisional


Pssm-ID: 235461 [Multi-domain]  Cd Length: 425  Bit Score: 35.81  E-value: 5.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1034645090 109 LKLDKDRKKIL--------ERKAKSRQVG--KEKGKYKEELIEKMQE 145
Cdd:PRK05431   31 LELDEERRELQteleelqaERNALSKEIGqaKRKGEDAEALIAEVKE 77
RplX COG0198
Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 ...
 47-85 9.63e-03

Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439968 [Multi-domain]  Cd Length: 104  Bit Score: 33.88  E-value: 9.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034645090  47 MPIRKDDEVQVVRGHYKGQQiGKVVQVYRKKYVIYIERV 85
Cdd:COG0198     3 MKIKKGDTVIVIAGKDKGKR-GKVLKVLPKKNRVIVEGV 40
 
Name Accession Description Interval E-value
Ribosomal_L26 pfam16906
Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the ...
 8-122 8.27e-70

Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the 60S ribosomal proteins from eukaryotes - L26 - and archaea - L25.


Pssm-ID: 465307 [Multi-domain]  Cd Length: 114  Bit Score: 205.43  E-value: 8.27e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034645090   8 TSDRSKNRKRHFNAPSHVRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQiGKVVQVYRKKYVIYIERVQR 87
Cdd:pfam16906   1 SSSRRKQRKAHFNAPSHIRRKLMSAPLSKELREKYGVRSLPIRKGDEVKVVRGDFKGRE-GKVVQVYRKKYRIHVEGVTR 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034645090  88 EKANGTTVHVGIHPSKVVITRLKLDKDRKKILERK 122
Cdd:pfam16906  80 EKANGTTVPVPIHPSKVVITKLKLDKDRKKILERK 114
PTZ00194 PTZ00194
60S ribosomal protein L26; Provisional
 3-137 1.71e-60

60S ribosomal protein L26; Provisional


Pssm-ID: 185508  Cd Length: 143  Bit Score: 183.03  E-value: 1.71e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034645090   3 FNPFVTSDRSKNRKRHFNAPSHVRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQiGKVVQVYRKKYVIYI 82
Cdd:PTZ00194    1 FNSIVSSSRRKARKAHFTAPSHLRRKLMSAPLSKELRAKYNVRSMPVRKDDEVMVVRGHHKGRE-GKVTAVYRKKWVIHI 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034645090  83 ERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSRQVGKEKGKYKE 137
Cdd:PTZ00194   80 EKITREKANGEPVQIGIHPSNVIITKLKLNKDRKAILERKARSTKSDKGKGKYTA 134
rplX_A_E TIGR01080
ribosomal protein uL24, archaeal/eukaryotic form; This model represents the archaeal and ...
 8-121 5.73e-44

ribosomal protein uL24, archaeal/eukaryotic form; This model represents the archaeal and eukaryotic branch of the ribosomal protein L24p/L26e family. Bacterial and organellar forms are represented by related model TIGR01079. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273432  Cd Length: 114  Bit Score: 140.37  E-value: 5.73e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034645090   8 TSDRSKNRKRHFNAPSHVRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQiGKVVQVYRKKYVIYIERVQR 87
Cdd:TIGR01080   1 SKQPRKQRKALFTAPLHERRKLMSAPLSKELREKYGKRALPIRKGDEVRIVRGDFKGHE-GKVSKVDRKRYRIYVEGVTK 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034645090  88 EKANGTTVHVGIHPSKVVITRLKLDKD-RKKILER 121
Cdd:TIGR01080  80 EKVDGTEVPVPLHPSNVMITKLHLDDEkRKKLLER 114
KOW_RPL26 cd06089
KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at ...
 52-106 6.04e-13

KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at their N terminal. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. RPL26 makes a very minor contributions to the biogenesis, structure, and function of 60s ribosomal subunits. However, RPL24 is essential to generate the first intermediate during 50s ribosomal subunits assembly. RPL26 have an extra-ribosomal function to enhances p53 translation after DNA damage.


Pssm-ID: 240513  Cd Length: 65  Bit Score: 59.84  E-value: 6.04e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034645090  52 DDEVQVVRGHYKGQQiGKVVQVYRKKYVIYIERVQREKAN-----------GTTVHVGIHPSKVVI 106
Cdd:cd06089     1 GDEVQVIRGKDKGKQ-GKVLKVDRKKNRVIVEGVNVVKKHvkpsqenpqggIIEVEAPIHISNVML 65
KOW pfam00467
KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, ...
 51-83 2.57e-03

KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.


Pssm-ID: 425698 [Multi-domain]  Cd Length: 32  Bit Score: 33.51  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1034645090  51 KDDEVQVVRGHYKGqQIGKVVQVYRKKYVIYIE 83
Cdd:pfam00467   1 KGDVVRVIAGPFKG-KVGKVVEVDDKKNRVLVE 32
PRK05431 PRK05431
seryl-tRNA synthetase; Provisional
 109-145 5.66e-03

seryl-tRNA synthetase; Provisional


Pssm-ID: 235461 [Multi-domain]  Cd Length: 425  Bit Score: 35.81  E-value: 5.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1034645090 109 LKLDKDRKKIL--------ERKAKSRQVG--KEKGKYKEELIEKMQE 145
Cdd:PRK05431   31 LELDEERRELQteleelqaERNALSKEIGqaKRKGEDAEALIAEVKE 77
RplX COG0198
Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 ...
 47-85 9.63e-03

Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439968 [Multi-domain]  Cd Length: 104  Bit Score: 33.88  E-value: 9.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034645090  47 MPIRKDDEVQVVRGHYKGQQiGKVVQVYRKKYVIYIERV 85
Cdd:COG0198     3 MKIKKGDTVIVIAGKDKGKR-GKVLKVLPKKNRVIVEGV 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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