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Conserved domains on  [gi|1034641399|ref|XP_016864181|]
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sodium/bile acid cotransporter 7 isoform X7 [Homo sapiens]

Protein Classification

bile acid:sodium symporter family protein( domain architecture ID 139610)

bile acid:sodium symporter (BASS) family protein, similar to Homo sapiens solute carrier family 10 (SLC10) proteins, which comprises influx transporters of bile acids, steroidal hormones, various drugs, and several other substrates

Gene Ontology:  GO:0015293|GO:0006810|GO:0016020|GO:0015293|GO:0015711
PubMed:  23506869|23177985
TCDB:  2.A.28

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SBF super family cl19217
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. ...
 10-75 3.88e-11

Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae; this is a putative transmembrane protein involved in resistance to arsenic compounds.


The actual alignment was detected with superfamily member pfam13593:

Pssm-ID: 450274  Cd Length: 313  Bit Score: 56.82  E-value: 3.88e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034641399  10 DWFMVGIVLAIAGAKLEPSIGVNGGPLKPEiTVSYIAVATIFFNSGLSLKTE-----FADSRLHASACVFC 75
Cdd:pfam13593   1 QWFLLGLVLAILLASLLPVFGAAGGPIRAE-YVITYGVALIFFLSGLRLSTEellagLRNWRLHLFVQLFT 70
 
Name Accession Description Interval E-value
SBF_like pfam13593
SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane ...
 10-75 3.88e-11

SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, pfam01758.


Pssm-ID: 433336  Cd Length: 313  Bit Score: 56.82  E-value: 3.88e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034641399  10 DWFMVGIVLAIAGAKLEPSIGVNGGPLKPEiTVSYIAVATIFFNSGLSLKTE-----FADSRLHASACVFC 75
Cdd:pfam13593   1 QWFLLGLVLAILLASLLPVFGAAGGPIRAE-YVITYGVALIFFLSGLRLSTEellagLRNWRLHLFVQLFT 70
 
Name Accession Description Interval E-value
SBF_like pfam13593
SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane ...
 10-75 3.88e-11

SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, pfam01758.


Pssm-ID: 433336  Cd Length: 313  Bit Score: 56.82  E-value: 3.88e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034641399  10 DWFMVGIVLAIAGAKLEPSIGVNGGPLKPEiTVSYIAVATIFFNSGLSLKTE-----FADSRLHASACVFC 75
Cdd:pfam13593   1 QWFLLGLVLAILLASLLPVFGAAGGPIRAE-YVITYGVALIFFLSGLRLSTEellagLRNWRLHLFVQLFT 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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