|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
11-308 |
2.09e-175 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
:
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 543.41 E-value: 2.09e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 11 SLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSsRLLYGNRVKDLVHREADEFTRQGQNFTLRQLGVCE 90
Cdd:pfam06484 1 SLTKRRRDKERRYTSSSADSEECRVPTQKSYSSSETLKAFDHDS-RMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 91 PATRRGLAFCAEMGLPHRGYSISAGSDADTENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSEN 170
Cdd:pfam06484 80 PSPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNEN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 171 -------------------------------------------------------------------EQPASNQGQSTLQ 183
Cdd:pfam06484 160 gppippsssssspveqhsppppslnenqrpllgnnashpildsdpdeefspnsylvrtgsgpqsapsEQPPNFQNHSRLR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 184 ----PLPPSHKQHSaQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTG 259
Cdd:pfam06484 240 tpppPLPPPHKQNQ-HHHPSINSLNRSSLTNRRNPSPAPTASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTG 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1034640494 260 TTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWK 308
Cdd:pfam06484 319 TTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL super family |
cl18310 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1155-1514 |
2.07e-41 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
The actual alignment was detected with superfamily member cd14953:
Pssm-ID: 302697 [Multi-domain] Cd Length: 323 Bit Score: 156.54 E-value: 2.07e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1155 VSSIMGNGRRrsiscpscnGQADGNKLLA----PVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSN 1228
Cdd:cd14953 1 VSTVAGSGTA---------GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1229 PAHRYY----LATDPvTGDLYVSDTNTRRIYRpksLTGAKDLTknaeVVAGTGEqclpfdeARCGDGGKAVEATLMSPKG 1304
Cdd:cd14953 72 AAAQFNtpsgVAVDA-AGNLYVADTGNHRIRK---ITPDGVVS----TLAGTGT-------AGFSDDGGATAAQFNYPTG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1305 MAVDKNGLIYFVDGT--MIRKVDQNGIISTLLGSNDLTSAR--PLTcdtsmhisQVRLEWPTDLAINPMDNsIYVLD--N 1378
Cdd:cd14953 137 VAVDAAGNLYVADTGnhRIRKITPDGVVTTVAGTGGAGYAGdgPAT--------AAQFNNPTGVAVDAAGN-LYVADrgN 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1379 NVVLQITENRQVRIAAGRPmhcqvpGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVA 1458
Cdd:cd14953 208 HRIRKITPDGVVTTVAGTG------TAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVA 278
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1034640494 1459 GIPSEcdckndancdcyQSGD-GYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAV 1514
Cdd:cd14953 279 GGGAG------------FSGDgGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2631-2708 |
7.77e-40 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
:
Pssm-ID: 464783 Cd Length: 78 Bit Score: 142.75 E-value: 7.77e-40
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034640494 2631 EEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLR 2708
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1468-2408 |
1.43e-33 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
:
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 142.59 E-value: 1.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1468 NDANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQ 1547
Cdd:COG3209 109 AAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGA 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1548 YTVSLVTGDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYH 1627
Cdd:COG3209 189 VTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTG 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1628 GNSGLLATK---SDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMV 1704
Cdd:COG3209 269 ASGAGLDAStgtGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTT 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1705 QDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLR 1784
Cdd:COG3209 349 VGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTA 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1785 VNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGR 1864
Cdd:COG3209 429 GGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGG 508
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1865 IVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDY 1944
Cdd:COG3209 509 TTTTTAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGT 588
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1945 NEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFicTIRYRQIGPLIDRQIFRFS 2024
Cdd:COG3209 589 ATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTG 666
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2025 EDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIK 2104
Cdd:COG3209 667 TGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2105 EIQYEifRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSA 2184
Cdd:COG3209 747 TSTTT--TTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSG 824
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2185 RLTPL-----RYDLRDRITRLgdvqyrldEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTviYRYDGLGRRVSSKTSLG 2259
Cdd:COG3209 825 GGTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATDPGTTES--YTYDANGNLTSRTDGGT 894
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2260 QHLQFFYADLtyPTRITHvynhSSSEITSLYYDLQGHlfameissgdefyiaSDNTGTPLAVFSSNGLMLKQIQYTAYGE 2339
Cdd:COG3209 895 TTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGN 953
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034640494 2340 IYFDSNIDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDPAPfNLYMFRNNNP 2408
Cdd:COG3209 954 LLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNP 1016
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
785-815 |
8.50e-08 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
:
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 50.21 E-value: 8.50e-08
10 20 30
....*....|....*....|....*....|.
gi 1034640494 785 AMETLCTDSKDNEGDGLIDCMDPDCCLQSSC 815
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| DUF5885 super family |
cl44670 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
522-676 |
8.81e-08 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
The actual alignment was detected with superfamily member pfam19232:
Pssm-ID: 437064 Cd Length: 265 Bit Score: 56.17 E-value: 8.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 522 CHGNGECvsGTCH-CFPGFLGPDCSraACPVLCSGNGQ----------YSKGRC----LCFSGwkgTECDVPTTQCI-DP 585
Cdd:pfam19232 34 CTTDAQC--GTCMtCVAGACTPKAS--CCGGVTCGAGQtcdaktntcvYVKGYCsadhPCPSG---SACDTAKNACIaQP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 586 QCG---GRGiCIMG-------------------SCACNSGYK-GESCE--------EADCIDP---------------GC 619
Cdd:pfam19232 107 PYGpdsGKG-CVRGfgawiweldpatnsgvwrcRCANGSLYNsAHECSpladqtlcAAENLDPnalvpassvpafaayGW 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 620 SNHGVCIH-------------GECHCSPGWGGSNCEILKTmcpdqCSGHGTYLQESGSCTCD------------PN---W 671
Cdd:pfam19232 186 GNQPVLINkstagaavpsplaGVCPCKPGWAGGSCTEDRT-----CNGRGTWNETTGQCACNidfsghnscgddNNctsW 260
|
....*
gi 1034640494 672 TGPDC 676
Cdd:pfam19232 261 TGPRC 265
|
|
| DSL super family |
cl19567 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
698-741 |
1.62e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
The actual alignment was detected with superfamily member pfam01414:
Pssm-ID: 473190 Cd Length: 46 Bit Score: 44.15 E-value: 1.62e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1034640494 698 CEEGWTGPACNqRACHPRCAE--HGTC-KDGKCECSQGWNGEHCTIA 741
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| C_rich_MXAN6577 super family |
cl49352 |
MXAN_6577-like cysteine-rich domain; |
681-776 |
1.65e-05 |
|
MXAN_6577-like cysteine-rich domain;
The actual alignment was detected with superfamily member NF041328:
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 47.06 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 681 CSVDCGSHGVCMGGTCRCEEGWT--GPAC--------NQRACHPRCAEHGTCKDGKCecsqgwngehctiahyldkivKE 750
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvdtasdpaHCGACGAACAPGQVCEGGAC---------------------RE 103
|
90 100 110
....*....|....*....|....*....|...
gi 1034640494 751 GCP-GLCNSNGRCT-LDQNGWHC-----VCQPG 776
Cdd:NF041328 104 ACSeGLTRCGGACVdLATDPLHCgacgvACDPG 136
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
11-308 |
2.09e-175 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 543.41 E-value: 2.09e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 11 SLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSsRLLYGNRVKDLVHREADEFTRQGQNFTLRQLGVCE 90
Cdd:pfam06484 1 SLTKRRRDKERRYTSSSADSEECRVPTQKSYSSSETLKAFDHDS-RMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 91 PATRRGLAFCAEMGLPHRGYSISAGSDADTENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSEN 170
Cdd:pfam06484 80 PSPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNEN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 171 -------------------------------------------------------------------EQPASNQGQSTLQ 183
Cdd:pfam06484 160 gppippsssssspveqhsppppslnenqrpllgnnashpildsdpdeefspnsylvrtgsgpqsapsEQPPNFQNHSRLR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 184 ----PLPPSHKQHSaQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTG 259
Cdd:pfam06484 240 tpppPLPPPHKQNQ-HHHPSINSLNRSSLTNRRNPSPAPTASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTG 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1034640494 260 TTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWK 308
Cdd:pfam06484 319 TTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1155-1514 |
2.07e-41 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 156.54 E-value: 2.07e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1155 VSSIMGNGRRrsiscpscnGQADGNKLLA----PVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSN 1228
Cdd:cd14953 1 VSTVAGSGTA---------GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1229 PAHRYY----LATDPvTGDLYVSDTNTRRIYRpksLTGAKDLTknaeVVAGTGEqclpfdeARCGDGGKAVEATLMSPKG 1304
Cdd:cd14953 72 AAAQFNtpsgVAVDA-AGNLYVADTGNHRIRK---ITPDGVVS----TLAGTGT-------AGFSDDGGATAAQFNYPTG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1305 MAVDKNGLIYFVDGT--MIRKVDQNGIISTLLGSNDLTSAR--PLTcdtsmhisQVRLEWPTDLAINPMDNsIYVLD--N 1378
Cdd:cd14953 137 VAVDAAGNLYVADTGnhRIRKITPDGVVTTVAGTGGAGYAGdgPAT--------AAQFNNPTGVAVDAAGN-LYVADrgN 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1379 NVVLQITENRQVRIAAGRPmhcqvpGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVA 1458
Cdd:cd14953 208 HRIRKITPDGVVTTVAGTG------TAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVA 278
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1034640494 1459 GIPSEcdckndancdcyQSGD-GYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAV 1514
Cdd:cd14953 279 GGGAG------------FSGDgGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2631-2708 |
7.77e-40 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 142.75 E-value: 7.77e-40
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034640494 2631 EEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLR 2708
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1468-2408 |
1.43e-33 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 142.59 E-value: 1.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1468 NDANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQ 1547
Cdd:COG3209 109 AAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGA 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1548 YTVSLVTGDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYH 1627
Cdd:COG3209 189 VTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTG 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1628 GNSGLLATK---SDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMV 1704
Cdd:COG3209 269 ASGAGLDAStgtGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTT 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1705 QDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLR 1784
Cdd:COG3209 349 VGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTA 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1785 VNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGR 1864
Cdd:COG3209 429 GGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGG 508
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1865 IVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDY 1944
Cdd:COG3209 509 TTTTTAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGT 588
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1945 NEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFicTIRYRQIGPLIDRQIFRFS 2024
Cdd:COG3209 589 ATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTG 666
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2025 EDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIK 2104
Cdd:COG3209 667 TGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2105 EIQYEifRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSA 2184
Cdd:COG3209 747 TSTTT--TTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSG 824
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2185 RLTPL-----RYDLRDRITRLgdvqyrldEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTviYRYDGLGRRVSSKTSLG 2259
Cdd:COG3209 825 GGTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATDPGTTES--YTYDANGNLTSRTDGGT 894
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2260 QHLQFFYADLtyPTRITHvynhSSSEITSLYYDLQGHlfameissgdefyiaSDNTGTPLAVFSSNGLMLKQIQYTAYGE 2339
Cdd:COG3209 895 TTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGN 953
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034640494 2340 IYFDSNIDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDPAPfNLYMFRNNNP 2408
Cdd:COG3209 954 LLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNP 1016
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1184-1462 |
1.69e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 61.19 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1184 PVALACGIDGSLYVGDF--NYVRRIFP-SGNVTsvlelrnkdfRHSSNPAHRYY-LATDPvTGDLYVSDTNTRRIYRpks 1259
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT----------EYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGR--- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1260 LTGAkdlTKNAEVVAGTGEQCLPFdearcgdggkaveatlmspkGMAVDKNGLIYFVDGT--MIRKVD-QNGIISTLLGS 1336
Cdd:COG4257 85 IDPK---TGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPLP 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1337 NDLTSARPLTCD--------------------TSMHISQVRLE----WPTDLAINPmDNSIYVLD--NNVVLQITEnrqv 1390
Cdd:COG4257 142 TGGAGPYGIAVDpdgnlwvtdfganaigridpDTGTLTEYALPtpgaGPRGLAVDP-DGNLWVADtgSGRIGRFDP---- 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034640494 1391 riAAGRpmhcqvpgveypVGKHAVQTTLESATAIAVSYSGVLYITETDekkINRIRQVTTDGEISLVAgIPS 1462
Cdd:COG4257 217 --KTGT------------VTEYPLPGGGARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTELTEYV-LPS 270
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2334-2408 |
4.08e-09 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 55.20 E-value: 4.08e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034640494 2334 YTAYGEIYFDSNIDFQLvIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDpAPFNLYMFRNNNP 2408
Cdd:TIGR03696 1 YDPYGEVLSESGAAPNP-LRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-----PIGLG-GGLNLYAYVGNNP 68
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
785-815 |
8.50e-08 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 50.21 E-value: 8.50e-08
10 20 30
....*....|....*....|....*....|.
gi 1034640494 785 AMETLCTDSKDNEGDGLIDCMDPDCCLQSSC 815
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
522-676 |
8.81e-08 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 56.17 E-value: 8.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 522 CHGNGECvsGTCH-CFPGFLGPDCSraACPVLCSGNGQ----------YSKGRC----LCFSGwkgTECDVPTTQCI-DP 585
Cdd:pfam19232 34 CTTDAQC--GTCMtCVAGACTPKAS--CCGGVTCGAGQtcdaktntcvYVKGYCsadhPCPSG---SACDTAKNACIaQP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 586 QCG---GRGiCIMG-------------------SCACNSGYK-GESCE--------EADCIDP---------------GC 619
Cdd:pfam19232 107 PYGpdsGKG-CVRGfgawiweldpatnsgvwrcRCANGSLYNsAHECSpladqtlcAAENLDPnalvpassvpafaayGW 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 620 SNHGVCIH-------------GECHCSPGWGGSNCEILKTmcpdqCSGHGTYLQESGSCTCD------------PN---W 671
Cdd:pfam19232 186 GNQPVLINkstagaavpsplaGVCPCKPGWAGGSCTEDRT-----CNGRGTWNETTGQCACNidfsghnscgddNNctsW 260
|
....*
gi 1034640494 672 TGPDC 676
Cdd:pfam19232 261 TGPRC 265
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
573-727 |
1.99e-07 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 52.45 E-value: 1.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 573 TECDVPTTQCIDPQ--CGGRGICIMGScACNSGykgeSCEEAdcidpgCSNHGVCIHGECHCSPGwggsnceilKTMCPD 650
Cdd:NF041328 12 AGCPEPGAVCPEGLsvCGGACVDLRSD-PSNCG----ACGVA------CGAGQTCVAGACGCGPG---------TVACGG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 651 QCSGHGTylqesgsctcDPNWTGPdcsneiCSVDCGSHGVCMGGTCR--CEEGWT--GPAC--------NQRACHPRCAE 718
Cdd:NF041328 72 ACVDTAS----------DPAHCGA------CGAACAPGQVCEGGACReaCSEGLTrcGGACvdlatdplHCGACGVACDP 135
|
....*....
gi 1034640494 719 HGTCKDGKC 727
Cdd:NF041328 136 GESCRGGAC 144
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1235-1518 |
8.29e-06 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 51.78 E-value: 8.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1235 LATDPVTGDLYVSDTNTRRIYrpksltgAKDLTKNAEV-VAGTGEQCL---PFDEArcgdggkaveaTLMSPKGMAVD-K 1309
Cdd:PLN02919 573 LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFEDA-----------TFNRPQGLAYNaK 634
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1310 NGLIYFVD--GTMIRKVD-QNGIISTLLGS----NDLTSARPLTcdtsmhiSQVrLEWPTDLAINPMDNSIYV------- 1375
Cdd:PLN02919 635 KNLLYVADteNHALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDVCFEPVNEKVYIamagqhq 706
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1376 ------LD-------------------------------------NNVVLQITENRQVR-----------IAAGRPMhcq 1401
Cdd:PLN02919 707 iweyniSDgvtrvfsgdgyernlngssgtstsfaqpsgislspdlKELYIADSESSSIRaldlktggsrlLAGGDPT--- 783
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1402 VPGVEYPVGKH---AVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTtdGEISLVAGIPsecdckndancdcyQSG 1478
Cdd:PLN02919 784 FSDNLFKFGDHdgvGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTG--------------KAG 847
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1034640494 1479 --DGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNK 1518
Cdd:PLN02919 848 fkDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
698-741 |
1.62e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 44.15 E-value: 1.62e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1034640494 698 CEEGWTGPACNqRACHPRCAE--HGTC-KDGKCECSQGWNGEHCTIA 741
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
681-776 |
1.65e-05 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 47.06 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 681 CSVDCGSHGVCMGGTCRCEEGWT--GPAC--------NQRACHPRCAEHGTCKDGKCecsqgwngehctiahyldkivKE 750
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvdtasdpaHCGACGAACAPGQVCEGGAC---------------------RE 103
|
90 100 110
....*....|....*....|....*....|...
gi 1034640494 751 GCP-GLCNSNGRCT-LDQNGWHC-----VCQPG 776
Cdd:NF041328 104 ACSeGLTRCGGACVdLATDPLHCgacgvACDPG 136
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1483-1609 |
1.03e-04 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 46.54 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1483 KDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKN-KPLLN-------SMNFYE---VASPTDQELYI----------FD 1541
Cdd:cd05819 3 GPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDgNFITSfgsfgsgDGQFNEpagVAVDSDGNLYVadtgnhriqkFD 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034640494 1542 INGTHQYTVSlVTGDYLYNFSY------SNDNDItAVTDSNGNtlRIrrdpnrmpvRVVSPDNQVIwLTIGTNG 1609
Cdd:cd05819 83 PDGNFLASFG-GSGDGDGEFNGprgiavDSSGNI-YVADTGNH--RI---------QKFDPDGEFL-TTFGSGG 142
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
667-709 |
1.46e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 41.46 E-value: 1.46e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1034640494 667 CDPNWTGPDCSNEiCSV--DCGSHGVC-MGGTCRCEEGWTGPACNQ 709
Cdd:pfam01414 1 CDENYYGSTCSKF-CRPrdDKFGHYTCdANGNKVCLPGWTGPYCDK 45
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
753-782 |
3.57e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.57e-03
10 20 30
....*....|....*....|....*....|
gi 1034640494 753 PGLCNSNGRCTLDQNGWHCVCQPGWRGAGC 782
Cdd:cd00054 8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1631-1662 |
8.44e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 36.04 E-value: 8.44e-03
10 20 30
....*....|....*....|....*....|..
gi 1034640494 1631 GLLATKSDETGWTTFFDYDSEGRLTNVTFPTG 1662
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
11-308 |
2.09e-175 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 543.41 E-value: 2.09e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 11 SLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSsRLLYGNRVKDLVHREADEFTRQGQNFTLRQLGVCE 90
Cdd:pfam06484 1 SLTKRRRDKERRYTSSSADSEECRVPTQKSYSSSETLKAFDHDS-RMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 91 PATRRGLAFCAEMGLPHRGYSISAGSDADTENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSEN 170
Cdd:pfam06484 80 PSPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNEN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 171 -------------------------------------------------------------------EQPASNQGQSTLQ 183
Cdd:pfam06484 160 gppippsssssspveqhsppppslnenqrpllgnnashpildsdpdeefspnsylvrtgsgpqsapsEQPPNFQNHSRLR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 184 ----PLPPSHKQHSaQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTG 259
Cdd:pfam06484 240 tpppPLPPPHKQNQ-HHHPSINSLNRSSLTNRRNPSPAPTASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTG 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1034640494 260 TTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWK 308
Cdd:pfam06484 319 TTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1155-1514 |
2.07e-41 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 156.54 E-value: 2.07e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1155 VSSIMGNGRRrsiscpscnGQADGNKLLA----PVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSN 1228
Cdd:cd14953 1 VSTVAGSGTA---------GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1229 PAHRYY----LATDPvTGDLYVSDTNTRRIYRpksLTGAKDLTknaeVVAGTGEqclpfdeARCGDGGKAVEATLMSPKG 1304
Cdd:cd14953 72 AAAQFNtpsgVAVDA-AGNLYVADTGNHRIRK---ITPDGVVS----TLAGTGT-------AGFSDDGGATAAQFNYPTG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1305 MAVDKNGLIYFVDGT--MIRKVDQNGIISTLLGSNDLTSAR--PLTcdtsmhisQVRLEWPTDLAINPMDNsIYVLD--N 1378
Cdd:cd14953 137 VAVDAAGNLYVADTGnhRIRKITPDGVVTTVAGTGGAGYAGdgPAT--------AAQFNNPTGVAVDAAGN-LYVADrgN 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1379 NVVLQITENRQVRIAAGRPmhcqvpGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVA 1458
Cdd:cd14953 208 HRIRKITPDGVVTTVAGTG------TAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVA 278
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1034640494 1459 GIPSEcdckndancdcyQSGD-GYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAV 1514
Cdd:cd14953 279 GGGAG------------FSGDgGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2631-2708 |
7.77e-40 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 142.75 E-value: 7.77e-40
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034640494 2631 EEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLR 2708
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1235-1515 |
2.13e-38 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 147.68 E-value: 2.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1235 LATDPvTGDLYVSDTNTRRIYRpksltgakdLTKNAEV--VAGTGEqclpfdEARCGDGGKAveATLMSPKGMAVDKNGL 1312
Cdd:cd14953 28 VAVDA-AGNLYVADRGNHRIRK---------ITPDGVVttVAGTGT------AGFADGGGAA--AQFNTPSGVAVDAAGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1313 IYFVDGT--MIRKVDQNGIISTLLGsndlTSARPLTCDTSMhiSQVRLEWPTDLAINPMDNsIYVLD--NNVVLQITENR 1388
Cdd:cd14953 90 LYVADTGnhRIRKITPDGVVSTLAG----TGTAGFSDDGGA--TAAQFNYPTGVAVDAAGN-LYVADtgNHRIRKITPDG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1389 QVRIAAGRPmhcqVPGveYPVGKHAVQTTLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVAGIPSEcdckn 1468
Cdd:cd14953 163 VVTTVAGTG----GAG--YAGDGPATAAQFNNPTGVAVDAAGNLYVADRGN---HRIRKITPDGVVTTVAGTGTA----- 228
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1034640494 1469 dancdcYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVS 1515
Cdd:cd14953 229 ------GFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHRIRKIT 269
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1468-2408 |
1.43e-33 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 142.59 E-value: 1.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1468 NDANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQ 1547
Cdd:COG3209 109 AAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGA 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1548 YTVSLVTGDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYH 1627
Cdd:COG3209 189 VTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTG 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1628 GNSGLLATK---SDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMV 1704
Cdd:COG3209 269 ASGAGLDAStgtGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTT 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1705 QDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLR 1784
Cdd:COG3209 349 VGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTA 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1785 VNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGR 1864
Cdd:COG3209 429 GGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGG 508
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1865 IVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDY 1944
Cdd:COG3209 509 TTTTTAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGT 588
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1945 NEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFicTIRYRQIGPLIDRQIFRFS 2024
Cdd:COG3209 589 ATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTG 666
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2025 EDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIK 2104
Cdd:COG3209 667 TGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2105 EIQYEifRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSA 2184
Cdd:COG3209 747 TSTTT--TTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSG 824
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2185 RLTPL-----RYDLRDRITRLgdvqyrldEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTviYRYDGLGRRVSSKTSLG 2259
Cdd:COG3209 825 GGTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATDPGTTES--YTYDANGNLTSRTDGGT 894
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2260 QHLQFFYADLtyPTRITHvynhSSSEITSLYYDLQGHlfameissgdefyiaSDNTGTPLAVFSSNGLMLKQIQYTAYGE 2339
Cdd:COG3209 895 TTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGN 953
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034640494 2340 IYFDSNIDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDPAPfNLYMFRNNNP 2408
Cdd:COG3209 954 LLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNP 1016
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1272-1515 |
1.81e-31 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 127.65 E-value: 1.81e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1272 VVAGTGeqclpfdeARCGDGGKAVEATLMSPKGMAVDKNGLIYFVDGT--MIRKVDQNGIISTLLG------SNDLTSAr 1343
Cdd:cd14953 3 TVAGSG--------TAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGnhRIRKITPDGVVTTVAGtgtagfADGGGAA- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1344 pltcdtsmhisqVRLEWPTDLAINPMDNsIYVLD--NNVVLQITENRQVRIAAGrpmhcqVPGVEYPVGKHAVQTTLESA 1421
Cdd:cd14953 74 ------------AQFNTPSGVAVDAAGN-LYVADtgNHRIRKITPDGVVSTLAG------TGTAGFSDDGGATAAQFNYP 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1422 TAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVAGIPSEcdckndancdcYQSGDGYAKDAKLSAPSSLAASPDGTL 1501
Cdd:cd14953 135 TGVAVDAAGNLYVADTGN---HRIRKITPDGVVTTVAGTGGA-----------GYAGDGPATAAQFNNPTGVAVDAAGNL 200
|
250
....*....|....
gi 1034640494 1502 YIADLGNIRIRAVS 1515
Cdd:cd14953 201 YVADRGNHRIRKIT 214
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1174-1512 |
2.75e-19 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 90.46 E-value: 2.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1174 GQADGnKLLAPVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSNPAHryyLATDPvTGDLYVSDTNT 1251
Cdd:cd05819 1 GTGPG-ELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSGDGQFNEPAG---VAVDS-DGNLYVADTGN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1252 RRIYRpksltgakdLTKNAEVVAGTGeqclpfdearcGDGGKAVEatLMSPKGMAVDKNGLIYFVDgTM---IRKVDQNG 1328
Cdd:cd05819 76 HRIQK---------FDPDGNFLASFG-----------GSGDGDGE--FNGPRGIAVDSSGNIYVAD-TGnhrIQKFDPDG 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1329 IISTLLGSNDLTSARpltcdtsmhisqvrLEWPTDLAINPmDNSIYVLDnnvvlqiTENRQVRI--AAGRPMHcQVPGVE 1406
Cdd:cd05819 133 EFLTTFGSGGSGPGQ--------------FNGPTGVAVDS-DGNIYVAD-------TGNHRIQVfdPDGNFLT-TFGSTG 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1407 YPVGKhavqttLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISlvagipsecdckndancdcYQSGDGYAKDAK 1486
Cdd:cd05819 190 TGPGQ------FNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDGAGF-------------------GGNGNFLGSDGQ 241
|
330 340
....*....|....*....|....*.
gi 1034640494 1487 LSAPSSLAASPDGTLYIADLGNIRIR 1512
Cdd:cd05819 242 FNRPSGLAVDSDGNLYVADTGNNRIQ 267
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1173-1445 |
4.36e-16 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 80.83 E-value: 4.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1173 NGQADGNkLLAPVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSNPahrYYLATDPvTGDLYVSDTN 1250
Cdd:cd05819 47 FGSGDGQ-FNEPAGVAVDSDGNLYVADTgnHRIQKFDPDGNFLASFGGSGDGDGEFNGP---RGIAVDS-SGNIYVADTG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1251 TRRIYRpksltgakdLTKNAEVVAGTGeqclpfdearcgdGGKAVEATLMSPKGMAVDKNGLIYFVDGT--MIRKVDQNG 1328
Cdd:cd05819 122 NHRIQK---------FDPDGEFLTTFG-------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGnhRIQVFDPDG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1329 IISTLLGSNDLTSARpltcdtsmhisqvrLEWPTDLAINPMDNsIYVLD--NNVVLQITENRQVRIAAGRPMhCQVPGVE 1406
Cdd:cd05819 180 NFLTTFGSTGTGPGQ--------------FNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNGNFL-GSDGQFN 243
|
250 260 270
....*....|....*....|....*....|....*....
gi 1034640494 1407 YPVGkhavqttlesataIAVSYSGVLYITETDEKKINRI 1445
Cdd:cd05819 244 RPSG-------------LAVDSDGNLYVADTGNNRIQVF 269
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1235-1511 |
1.14e-09 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 61.45 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1235 LATDPvTGDLYVSDTNTRRIYRpksltgakdltknaeVVAGTGEQ-CLPFDEarcgdggkaveatLMSPKGMAVDKNGLI 1313
Cdd:cd14952 15 VAVDA-AGNVYVADSGNNRVLK---------------LAAGSTTQtVLPFTG-------------LYQPQGVAVDAAGTV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1314 YFVDGtmirkvDQNGIISTLLGSNDLTsARPLTcdtsmhisqvRLEWPTDLAINPMDNsIYVLDNnvvlqiTENRQVRIA 1393
Cdd:cd14952 66 YVTDF------GNNRVLKLAAGSTTQT-VLPFT----------GLNDPTGVAVDAAGN-VYVADT------GNNRVLKLA 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1394 AGRPMHCQVPgveypvgkhavQTTLESATAIAVSYSGVLYITETDEkkiNRIRQvttdgeisLVAGipsecdckndANCD 1473
Cdd:cd14952 122 AGSNTQTVLP-----------FTGLSNPDGVAVDGAGNVYVTDTGN---NRVLK--------LAAG----------STTQ 169
|
250 260 270
....*....|....*....|....*....|....*...
gi 1034640494 1474 CYQSGDGyakdakLSAPSSLAASPDGTLYIADLGNIRI 1511
Cdd:cd14952 170 TVLPFTG------LNSPSGVAVDTAGNVYVTDHGNNRV 201
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1184-1462 |
1.69e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 61.19 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1184 PVALACGIDGSLYVGDF--NYVRRIFP-SGNVTsvlelrnkdfRHSSNPAHRYY-LATDPvTGDLYVSDTNTRRIYRpks 1259
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT----------EYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGR--- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1260 LTGAkdlTKNAEVVAGTGEQCLPFdearcgdggkaveatlmspkGMAVDKNGLIYFVDGT--MIRKVD-QNGIISTLLGS 1336
Cdd:COG4257 85 IDPK---TGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPLP 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1337 NDLTSARPLTCD--------------------TSMHISQVRLE----WPTDLAINPmDNSIYVLD--NNVVLQITEnrqv 1390
Cdd:COG4257 142 TGGAGPYGIAVDpdgnlwvtdfganaigridpDTGTLTEYALPtpgaGPRGLAVDP-DGNLWVADtgSGRIGRFDP---- 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034640494 1391 riAAGRpmhcqvpgveypVGKHAVQTTLESATAIAVSYSGVLYITETDekkINRIRQVTTDGEISLVAgIPS 1462
Cdd:COG4257 217 --KTGT------------VTEYPLPGGGARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTELTEYV-LPS 270
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2334-2408 |
4.08e-09 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 55.20 E-value: 4.08e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034640494 2334 YTAYGEIYFDSNIDFQLvIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDpAPFNLYMFRNNNP 2408
Cdd:TIGR03696 1 YDPYGEVLSESGAAPNP-LRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-----PIGLG-GGLNLYAYVGNNP 68
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1299-1609 |
4.34e-08 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 57.28 E-value: 4.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1299 LMSPKGMAVDKNGLIYFVD--GTMIRKVDQNGIISTLLGSNDltsarpltcdtsmhISQVRLEWPTDLAINPMDNsIYVL 1376
Cdd:cd14957 17 FNTPRGIAVDSAGNIYVADtgNNRIQVFTSSGVYSYSIGSGG--------------TGSGQFNSPYGIAVDSNGN-IYVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1377 DNNvvlqitENR-QVRIAAGrpmhcqvpGVEYPVGKHAVQTT-LESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEI 1454
Cdd:cd14957 82 DTD------NNRiQVFNSSG--------VYQYSIGTGGSGDGqFNGPYGIAVDSNGNIYVADTGN---HRIQVFTSSGTF 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1455 slvagipsecdckndancdCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRavsknkpllnsmnfyevasptd 1534
Cdd:cd14957 145 -------------------SYSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQ---------------------- 183
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034640494 1535 qelyIFDINGTHQYTV-SLVTGDYLynFSYSNDNDItavtDSNGNTLRIRRDPNRmpVRVVSPDNqVIWLTIGTNG 1609
Cdd:cd14957 184 ----VFTSSGTFQYTFgSSGSGPGQ--FSDPYGIAV----DSDGNIYVADTGNHR--IQVFTSSG-AYQYSIGTSG 246
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
785-815 |
8.50e-08 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 50.21 E-value: 8.50e-08
10 20 30
....*....|....*....|....*....|.
gi 1034640494 785 AMETLCTDSKDNEGDGLIDCMDPDCCLQSSC 815
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
522-676 |
8.81e-08 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 56.17 E-value: 8.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 522 CHGNGECvsGTCH-CFPGFLGPDCSraACPVLCSGNGQ----------YSKGRC----LCFSGwkgTECDVPTTQCI-DP 585
Cdd:pfam19232 34 CTTDAQC--GTCMtCVAGACTPKAS--CCGGVTCGAGQtcdaktntcvYVKGYCsadhPCPSG---SACDTAKNACIaQP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 586 QCG---GRGiCIMG-------------------SCACNSGYK-GESCE--------EADCIDP---------------GC 619
Cdd:pfam19232 107 PYGpdsGKG-CVRGfgawiweldpatnsgvwrcRCANGSLYNsAHECSpladqtlcAAENLDPnalvpassvpafaayGW 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 620 SNHGVCIH-------------GECHCSPGWGGSNCEILKTmcpdqCSGHGTYLQESGSCTCD------------PN---W 671
Cdd:pfam19232 186 GNQPVLINkstagaavpsplaGVCPCKPGWAGGSCTEDRT-----CNGRGTWNETTGQCACNidfsghnscgddNNctsW 260
|
....*
gi 1034640494 672 TGPDC 676
Cdd:pfam19232 261 TGPRC 265
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
573-727 |
1.99e-07 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 52.45 E-value: 1.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 573 TECDVPTTQCIDPQ--CGGRGICIMGScACNSGykgeSCEEAdcidpgCSNHGVCIHGECHCSPGwggsnceilKTMCPD 650
Cdd:NF041328 12 AGCPEPGAVCPEGLsvCGGACVDLRSD-PSNCG----ACGVA------CGAGQTCVAGACGCGPG---------TVACGG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 651 QCSGHGTylqesgsctcDPNWTGPdcsneiCSVDCGSHGVCMGGTCR--CEEGWT--GPAC--------NQRACHPRCAE 718
Cdd:NF041328 72 ACVDTAS----------DPAHCGA------CGAACAPGQVCEGGACReaCSEGLTrcGGACvdlatdplHCGACGVACDP 135
|
....*....
gi 1034640494 719 HGTCKDGKC 727
Cdd:NF041328 136 GESCRGGAC 144
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1233-1512 |
6.44e-07 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 53.48 E-value: 6.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1233 YYLATDPvTGDLYVSDTNTRRIYRpksltgakdltknaeVVAGTGEqclpFDEARCGDGGkaveatlmSPKGMAVDKNGL 1312
Cdd:COG4257 20 RDVAVDP-DGAVWFTDQGGGRIGR---------------LDPATGE----FTEYPLGGGS--------GPHGIAVDPDGN 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1313 IYFVDGT--MIRKVD-QNGIISTLLGSNDLTSarpltcdtsmhisqvrlewPTDLAINPmDNSIYVLD--NNVVLQIT-E 1386
Cdd:COG4257 72 LWFTDNGnnRIGRIDpKTGEITTFALPGGGSN-------------------PHGIAFDP-DGNLWFTDqgGNRIGRLDpA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1387 NRQVRiaagrpmhcqvpgvEYPVGKHAVQTTlesatAIAVSYSGVLYITETdekKINRIRQVTTD-GEISLvagipsecd 1465
Cdd:COG4257 132 TGEVT--------------EFPLPTGGAGPY-----GIAVDPDGNLWVTDF---GANAIGRIDPDtGTLTE--------- 180
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1034640494 1466 ckndancdcyqsgdgYAKDAKLSAPSSLAASPDGTLYIADLGNIRIR 1512
Cdd:COG4257 181 ---------------YALPTPGAGPRGLAVDPDGNLWVADTGSGRIG 212
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1181-1442 |
9.04e-07 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 52.60 E-value: 9.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1181 LLAPVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLElrnkdFRHSSNPAHryyLATDPVtGDLYVSDTNTRRIyrpk 1258
Cdd:cd14952 51 LYQPQGVAVDAAGTVYVTDFgnNRVLKLAAGSTTQTVLP-----FTGLNDPTG---VAVDAA-GNVYVADTGNNRV---- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1259 sltgakdltknAEVVAGTGEQC-LPFdearcgdggkaveATLMSPKGMAVDKNGLIYFVDGtmirkvDQNGIISTLLGSN 1337
Cdd:cd14952 118 -----------LKLAAGSNTQTvLPF-------------TGLSNPDGVAVDGAGNVYVTDT------GNNRVLKLAAGST 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1338 DLTsARPLTCDTSmhisqvrlewPTDLAINPMDNsIYVLDNNvvlqitENRQVRIAAGRPMHCQVP--GVEYPVGkhavq 1415
Cdd:cd14952 168 TQT-VLPFTGLNS----------PSGVAVDTAGN-VYVTDHG------NNRVLKLAAGSTTPTVLPftGLNGPLG----- 224
|
250 260
....*....|....*....|....*..
gi 1034640494 1416 ttlesataIAVSYSGVLYITETDEKKI 1442
Cdd:cd14952 225 --------VAVDAAGNVYVADRGNDRV 243
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1235-1518 |
8.29e-06 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 51.78 E-value: 8.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1235 LATDPVTGDLYVSDTNTRRIYrpksltgAKDLTKNAEV-VAGTGEQCL---PFDEArcgdggkaveaTLMSPKGMAVD-K 1309
Cdd:PLN02919 573 LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFEDA-----------TFNRPQGLAYNaK 634
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1310 NGLIYFVD--GTMIRKVD-QNGIISTLLGS----NDLTSARPLTcdtsmhiSQVrLEWPTDLAINPMDNSIYV------- 1375
Cdd:PLN02919 635 KNLLYVADteNHALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDVCFEPVNEKVYIamagqhq 706
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1376 ------LD-------------------------------------NNVVLQITENRQVR-----------IAAGRPMhcq 1401
Cdd:PLN02919 707 iweyniSDgvtrvfsgdgyernlngssgtstsfaqpsgislspdlKELYIADSESSSIRaldlktggsrlLAGGDPT--- 783
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1402 VPGVEYPVGKH---AVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTtdGEISLVAGIPsecdckndancdcyQSG 1478
Cdd:PLN02919 784 FSDNLFKFGDHdgvGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTG--------------KAG 847
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1034640494 1479 --DGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNK 1518
Cdd:PLN02919 848 fkDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
698-741 |
1.62e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 44.15 E-value: 1.62e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1034640494 698 CEEGWTGPACNqRACHPRCAE--HGTC-KDGKCECSQGWNGEHCTIA 741
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
681-776 |
1.65e-05 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 47.06 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 681 CSVDCGSHGVCMGGTCRCEEGWT--GPAC--------NQRACHPRCAEHGTCKDGKCecsqgwngehctiahyldkivKE 750
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvdtasdpaHCGACGAACAPGQVCEGGAC---------------------RE 103
|
90 100 110
....*....|....*....|....*....|...
gi 1034640494 751 GCP-GLCNSNGRCT-LDQNGWHC-----VCQPG 776
Cdd:NF041328 104 ACSeGLTRCGGACVdLATDPLHCgacgvACDPG 136
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1180-1437 |
4.64e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 47.67 E-value: 4.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1180 KLLAPVALACGIDGSLYVGDFnYVRRI--F-PSGNVTSVLElRNKDFRHSSNPAHryyLATDpvTGDLYVSDTNTRRIYr 1256
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADL-YNGRIqvFdPDGKFLKYFP-EKKDRVKLISPAG---LAID--DGKLYVSDVKKHKVI- 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1257 pksltgakdltknaeVVAGTGEQCLPFdearcGDGGKAvEATLMSPKGMAVDKNGLIYFVD--GTMIRKVDQNG-IISTL 1333
Cdd:cd14963 126 ---------------VFDLEGKLLLEF-----GKPGSE-PGELSYPNGIAVDEDGNIYVADsgNGRIQVFDKNGkFIKEL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1334 LGSNDLTSArpltcdtsmhisqvrLEWPTDLAINPmDNSIYVLDN--NVVLQITENRQVRIAAGRpmhcqvPGVEypvgk 1411
Cdd:cd14963 185 NGSPDGKSG---------------FVNPRGIAVDP-DGNLYVVDNlsHRVYVFDEQGKELFTFGG------RGKD----- 237
|
250 260
....*....|....*....|....*.
gi 1034640494 1412 havQTTLESATAIAVSYSGVLYITET 1437
Cdd:cd14963 238 ---DGQFNLPNGLFIDDDGRLYVTDR 260
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1483-1609 |
1.03e-04 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 46.54 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1483 KDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKN-KPLLN-------SMNFYE---VASPTDQELYI----------FD 1541
Cdd:cd05819 3 GPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDgNFITSfgsfgsgDGQFNEpagVAVDSDGNLYVadtgnhriqkFD 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034640494 1542 INGTHQYTVSlVTGDYLYNFSY------SNDNDItAVTDSNGNtlRIrrdpnrmpvRVVSPDNQVIwLTIGTNG 1609
Cdd:cd05819 83 PDGNFLASFG-GSGDGDGEFNGprgiavDSSGNI-YVADTGNH--RI---------QKFDPDGEFL-TTFGSGG 142
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
667-709 |
1.46e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 41.46 E-value: 1.46e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1034640494 667 CDPNWTGPDCSNEiCSV--DCGSHGVC-MGGTCRCEEGWTGPACNQ 709
Cdd:pfam01414 1 CDENYYGSTCSKF-CRPrdDKFGHYTCdANGNKVCLPGWTGPYCDK 45
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1477-1517 |
2.04e-04 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 45.98 E-value: 2.04e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1034640494 1477 SGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKN 1517
Cdd:cd14953 12 FSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPD 52
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
522-544 |
4.87e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.25 E-value: 4.87e-04
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1839-1879 |
1.02e-03 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 38.73 E-value: 1.02e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1034640494 1839 YSSTGQ-IASIQRGTTSEKVDYDGQGRIVSRVFADGKTWSYT 1879
Cdd:TIGR01643 1 YDAAGRlTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1187-1330 |
1.10e-03 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 43.34 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1187 LACGIDGSLYVGDFNYVR------RIFPSGNVTSVLElrnkDFrHSSN-----PAHRYylatdpvtgdLYVSDTNTRRIY 1255
Cdd:COG3386 98 GVVDPDGRLYFTDMGEYLptgalyRVDPDGSLRVLAD----GL-TFPNgiafsPDGRT----------LYVADTGAGRIY 162
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034640494 1256 R-PKSLTGAkdLTkNAEVVAgtgeqclpfdEARCGDGGkaveatlmsPKGMAVDKNGLIY--FVDGTMIRKVDQNGII 1330
Cdd:COG3386 163 RfDLDADGT--LG-NRRVFA----------DLPDGPGG---------PDGLAVDADGNLWvaLWGGGGVVRFDPDGEL 218
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
652-676 |
1.18e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 1.18e-03
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
609-727 |
1.19e-03 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 42.09 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 609 CEEADCIDPGCSNHGVCihGECHCSPGWGGSNCeILKTMCPDQCSGHGTYLQESGSCTCDPNwTGPDCSNEICSVDCGSH 688
Cdd:pfam01500 4 CGTSFCGFPTCSTGGTC--GSGCCQPCCCQSSC-CRPSCCQTSCCQPTTFQSSCCRPTCQPC-CQTSCCQPTCCQTSSCQ 79
|
90 100 110
....*....|....*....|....*....|....*....
gi 1034640494 689 GVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKC 727
Cdd:pfam01500 80 TGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCC 118
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
619-641 |
1.87e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 1.87e-03
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1486-1582 |
1.97e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 42.66 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1486 KLSAPSSLAASPDGTLYIADLGNIRIRAVSKN----------KPLLNSM----------NFYeVASPTDQELYIFDINGT 1545
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADLYNGRIQVFDPDgkflkyfpekKDRVKLIspaglaiddgKLY-VSDVKKHKVIVFDLEGK 132
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1034640494 1546 HQYTVSLVtGDYLYNFSYSN------DNDItAVTDSNGNtlRI 1582
Cdd:cd14963 133 LLLEFGKP-GSEPGELSYPNgiavdeDGNI-YVADSGNG--RI 171
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1179-1256 |
2.60e-03 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 42.31 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1179 NKLLAPVALACGIDGSLYVGDF--NYVRRIFP-SGNVTSvlelrnkdFRHSSNPAHRYYLATDPvTGDLYVSDTNTRRIY 1255
Cdd:COG4257 185 TPGAGPRGLAVDPDGNLWVADTgsGRIGRFDPkTGTVTE--------YPLPGGGARPYGVAVDG-DGRVWFAESGANRIV 255
|
.
gi 1034640494 1256 R 1256
Cdd:COG4257 256 R 256
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
753-782 |
3.57e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.57e-03
10 20 30
....*....|....*....|....*....|
gi 1034640494 753 PGLCNSNGRCTLDQNGWHCVCQPGWRGAGC 782
Cdd:cd00054 8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| NHL_like_6 |
cd14962 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1292-1511 |
5.03e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 41.42 E-value: 5.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1292 GKAVEATLMSPKGMAVDKNGLIYFVDGT--MIRKVDQNGIISTLLGSNDLtsarpltcdtsmhisQVRlewPTDLAINPM 1369
Cdd:cd14962 49 GNAGPNRFVSPIGVAIDANGNLYVSDAElgKVFVFDRDGKFLRAIGAGAL---------------FKR---PTGIAVDPA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1370 DNSIYVLDnnvvlqiTENRQVRI--AAGRPMHcQVPgveyPVGKHAVQttLESATAIAVSYSGVLYITETDEKKINRI-- 1445
Cdd:cd14962 111 GKRLYVVD-------TLAHKVKVfdLDGRLLF-DIG----KRGSGPGE--FNLPTDLAVDRDGNLYVTDTMNFRVQIFda 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1446 --RQVTTDGEISLVAG---IPSECDCKNDAN---CDCYQS---------------GDGYAKDAKLSAPSSLAASPDGTLY 1502
Cdd:cd14962 177 dgKFLRSFGERGDGPGsfaRPKGIAVDSEGNiyvVDAAFDnvqifnpegellltvGGPGSGPGEFYLPSGIAIDKDDRIY 256
|
....*....
gi 1034640494 1503 IADLGNIRI 1511
Cdd:cd14962 257 VVDQFNRRI 265
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
587-609 |
7.69e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.17 E-value: 7.69e-03
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1631-1662 |
8.44e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 36.04 E-value: 8.44e-03
10 20 30
....*....|....*....|....*....|..
gi 1034640494 1631 GLLATKSDETGWTTFFDYDSEGRLTNVTFPTG 1662
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| EGF |
pfam00008 |
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
756-779 |
8.91e-03 |
|
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.
Pssm-ID: 394967 Cd Length: 31 Bit Score: 35.82 E-value: 8.91e-03
|
| |
