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Conserved domains on  [gi|1034619223|ref|XP_016860958|]
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aquaporin-7B isoform X4 [Homo sapiens]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  8849412|11473620|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 3-129 1.43e-25

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member cd00333:

Pssm-ID: 444743  Cd Length: 228  Bit Score: 98.48  E-value: 1.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034619223   3 TGPFATAGIFATYLPDHMTLWRGFLNEEWLTRMLQLCLFTITDQENNPALPGTHALVISILVVIIRVSHGINTGYAINPS 82
Cdd:cd00333   110 GANNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPA 189

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1034619223  83 RDPPPSIFT-FIAGWgkqvfsdgeNWWWVPVVAPLLGASLGGIIYLVF 129
Cdd:cd00333   190 RSLGPALFTgLARHW---------HYFWVYWVGPLIGAIAGALVYDYV 228
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 3-129 1.43e-25

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 98.48  E-value: 1.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034619223   3 TGPFATAGIFATYLPDHMTLWRGFLNEEWLTRMLQLCLFTITDQENNPALPGTHALVISILVVIIRVSHGINTGYAINPS 82
Cdd:cd00333   110 GANNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPA 189

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1034619223  83 RDPPPSIFT-FIAGWgkqvfsdgeNWWWVPVVAPLLGASLGGIIYLVF 129
Cdd:cd00333   190 RSLGPALFTgLARHW---------HYFWVYWVGPLIGAIAGALVYDYV 228
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 3-134 4.51e-24

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 95.96  E-value: 4.51e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034619223   3 TGPFATAGIFATYLPDHMTlwRGFLNEEWLTRMLQLCLFTITDQENNPALpGTHALVISILVVIIRVSHGINTGYAINPS 82
Cdd:PTZ00016  166 TMANGFAGVFATYPREGNF--YAIFSELILTAILLLVILAITDPNNCPAF-NYLPVAVGLLVFVIGISFGGNTGYALNPA 242

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034619223  83 RDPPPSIFTFIAgWGKQVFSDGENWWWVPVVAPLLGASLGGIIYLVFIGSTI 134
Cdd:PTZ00016  243 RDLGPRLFSAIL-WGSEVFTKDNYYFWVPLVAPFVGAVLGMFLYDKFIPPLI 293
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 4-131 3.16e-20

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 84.41  E-value: 3.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034619223   4 GPFATAGIFATYLPDHMTLWRGFLNEEWLTRMLQLCLFTITDQENNPAlpGTHALVISILVVIIRVSHGINTGYAINPSR 83
Cdd:COG0580   112 DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPG--GLAPLAIGLLVAAIGLSLGPLTGYAINPAR 189

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034619223  84 DPPPSIFTFIagwgkqvFSDGENW--WWVPVVAPLLGASLGGIIYLVFIG 131
Cdd:COG0580   190 DLGPRLFHAL-------GKGGSDWgyLWVPIVAPILGAALAALLYRALFG 232
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 12-126 2.00e-18

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 79.26  E-value: 2.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034619223  12 FATYLPDHMTLWRGFLNEEWLTRMLQLCLFTITDQENNPALPGTHALVISILVVIIRVSHGINTGYAINPSRDPPPSIFT 91
Cdd:TIGR00861 111 VNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFA 190

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034619223  92 FIAGWGKqvfsdgenwWWVPVVAPLLGASLGGIIY 126
Cdd:TIGR00861 191 GLAGWGN---------HWVYWVGPIIGAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 2-126 2.30e-14

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 68.50  E-value: 2.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034619223   2 VTGPFATAGIFATYLPDHMTLWRGFLNEEWLTRMLQLCLFTITDQENNPALPGTHALVISILVVIIRVSHGINTGYAINP 81
Cdd:pfam00230 110 VTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNP 189

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1034619223  82 SRDPPPSIFTFiagwgkqvfsdgeNW--WWVPVVAPLLGASLGGIIY 126
Cdd:pfam00230 190 ARSFGPAVVLW-------------KWddHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 3-129 1.43e-25

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 98.48  E-value: 1.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034619223   3 TGPFATAGIFATYLPDHMTLWRGFLNEEWLTRMLQLCLFTITDQENNPALPGTHALVISILVVIIRVSHGINTGYAINPS 82
Cdd:cd00333   110 GANNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPA 189

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1034619223  83 RDPPPSIFT-FIAGWgkqvfsdgeNWWWVPVVAPLLGASLGGIIYLVF 129
Cdd:cd00333   190 RSLGPALFTgLARHW---------HYFWVYWVGPLIGAIAGALVYDYV 228
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 3-134 4.51e-24

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 95.96  E-value: 4.51e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034619223   3 TGPFATAGIFATYLPDHMTlwRGFLNEEWLTRMLQLCLFTITDQENNPALpGTHALVISILVVIIRVSHGINTGYAINPS 82
Cdd:PTZ00016  166 TMANGFAGVFATYPREGNF--YAIFSELILTAILLLVILAITDPNNCPAF-NYLPVAVGLLVFVIGISFGGNTGYALNPA 242

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034619223  83 RDPPPSIFTFIAgWGKQVFSDGENWWWVPVVAPLLGASLGGIIYLVFIGSTI 134
Cdd:PTZ00016  243 RDLGPRLFSAIL-WGSEVFTKDNYYFWVPLVAPFVGAVLGMFLYDKFIPPLI 293
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 4-131 3.16e-20

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 84.41  E-value: 3.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034619223   4 GPFATAGIFATYLPDHMTLWRGFLNEEWLTRMLQLCLFTITDQENNPAlpGTHALVISILVVIIRVSHGINTGYAINPSR 83
Cdd:COG0580   112 DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPG--GLAPLAIGLLVAAIGLSLGPLTGYAINPAR 189

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034619223  84 DPPPSIFTFIagwgkqvFSDGENW--WWVPVVAPLLGASLGGIIYLVFIG 131
Cdd:COG0580   190 DLGPRLFHAL-------GKGGSDWgyLWVPIVAPILGAALAALLYRALFG 232
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 12-126 2.00e-18

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 79.26  E-value: 2.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034619223  12 FATYLPDHMTLWRGFLNEEWLTRMLQLCLFTITDQENNPALPGTHALVISILVVIIRVSHGINTGYAINPSRDPPPSIFT 91
Cdd:TIGR00861 111 VNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFA 190

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034619223  92 FIAGWGKqvfsdgenwWWVPVVAPLLGASLGGIIY 126
Cdd:TIGR00861 191 GLAGWGN---------HWVYWVGPIIGAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 2-126 2.30e-14

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 68.50  E-value: 2.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034619223   2 VTGPFATAGIFATYLPDHMTLWRGFLNEEWLTRMLQLCLFTITDQENNPALPGTHALVISILVVIIRVSHGINTGYAINP 81
Cdd:pfam00230 110 VTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNP 189

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1034619223  82 SRDPPPSIFTFiagwgkqvfsdgeNW--WWVPVVAPLLGASLGGIIY 126
Cdd:pfam00230 190 ARSFGPAVVLW-------------KWddHWVYWVGPFIGAALGALVY 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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