|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
89-592 |
0e+00 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 551.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 89 EPVKSFSKTQRWAEPGEPICVVCGRYGEYICDKTDEDVCSLECKAKHLLQVKEKEEKSKLSNPQKADSEPESplnasYVY 168
Cdd:PLN00206 12 DVVKERSIEQREALPGEPKCVVCGRYGEYICDETDDDICSLECKQALLRRVAKSRVAVGAPKPKRLPATDEC-----FYV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 169 KEHPFILNLQEDQIENLKQQLGILVQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASAD 248
Cdd:PLN00206 87 RDPGSTSGLSSSQAELLRRKLEIHVKGEAVPPPILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSAD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 249 TGSGKTAAFLLPVIMRA-------LFESKTPSALILTPTRELAIQIERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLQQ 321
Cdd:PLN00206 167 TGSGKTASFLVPIISRCctirsghPSEQRNPLAMVLTPTRELCVQVEDQAKVLGKGLP-FKTALVVGGDAMPQQLYRIQQ 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 322 HVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIPNDcQTILVSATIPTSIEQLASQLLHN 401
Cdd:PLN00206 246 GVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQALSQP-QVLLFSATVSPEVEKFASSLAKD 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 402 PVRIITGEKNLPCANVRQIILWVEDPAKKKKLFEILNDKKLFKPPVLVFVDCKLGADLLSEAVQKITGLKSISIHSEKSQ 481
Cdd:PLN00206 325 IILISIGNPNRPNKAVKQLAIWVETKQKKQKLFDILKSKQHFKPPAVVFVSSRLGADLLANAITVVTGLKALSIHGEKSM 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 482 IERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRLGQNGTAITFINNNSKRLFWDIA 561
Cdd:PLN00206 405 KERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNLFPELV 484
|
490 500 510
....*....|....*....|....*....|..
gi 1034562211 562 KRVKPTGSILPPQLLNSPYL-HDQKRKEQQKD 592
Cdd:PLN00206 485 ALLKSSGAAIPRELANSRYLgSGRKRKKKRRY 516
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
205-593 |
2.04e-130 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 389.12 E-value: 2.04e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 205 FEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFE-SKTPSALILTPTREL 283
Cdd:COG0513 4 FADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSrPRAPQALILAPTREL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 284 AIQIERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGF 363
Cdd:COG0513 84 ALQVAEELRKLAKYLG-LRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDMGF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 364 QQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVEDPAKKKKLFEILNDKKLF 443
Cdd:COG0513 163 IEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRLLRDEDPE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 444 KppVLVFVDCKLGADLLSEAVQKiTGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMP 523
Cdd:COG0513 243 R--AIVFCNTKRGADRLAEKLQK-RGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLP 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 524 SSMDEYVHQIGRVGRLGQNGTAITFINNNSKRLFWDIAKRvkpTGSILPPQLLNSPYLHDQKRKEQQKDK 593
Cdd:COG0513 320 EDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKL---IGQKIEEEELPGFEPVEEKRLERLKPK 386
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
214-406 |
1.46e-123 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 363.02 E-value: 1.46e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 214 LNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRELAIQIERQAKE 293
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQAKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 294 LMSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILEN 373
Cdd:cd17962 81 LMKGLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVLDILEN 160
|
170 180 190
....*....|....*....|....*....|...
gi 1034562211 374 IPNDCQTILVSATIPTSIEQLASQLLHNPVRII 406
Cdd:cd17962 161 ISHDHQTILVSATIPRGIEQLAGQLLQNPVRIT 193
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
168-590 |
1.47e-97 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 308.63 E-value: 1.47e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 168 YKEHPFILNLQEDQIENLKQQLGI-LVQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILAS 246
Cdd:PTZ00110 94 YKEHPEVSALSSKEVDEIRKEKEItIIAGENVPKPVVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGI 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 247 ADTGSGKTAAFLLPVIMRALFESKT-----PSALILTPTRELAIQIERQAKELmSGLPRMKTVLLVGGLPLPPQLYRLQQ 321
Cdd:PTZ00110 174 AETGSGKTLAFLLPAIVHINAQPLLrygdgPIVLVLAPTRELAEQIREQCNKF-GASSKIRNTVAYGGVPKRGQIYALRR 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 322 HVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLL-H 400
Cdd:PTZ00110 253 GVEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCkE 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 401 NPVRIITGEKNL-PCANVRQIILWVEDPAKKKKLFEILndKKLFKP--PVLVFVDCKLGADLLSEAVqKITGLKSISIHS 477
Cdd:PTZ00110 333 EPVHVNVGSLDLtACHNIKQEVFVVEEHEKRGKLKMLL--QRIMRDgdKILIFVETKKGADFLTKEL-RLDGWPALCIHG 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 478 EKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRLGQNGTAITFINNNSKRLF 557
Cdd:PTZ00110 410 DKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPDKYRLA 489
|
410 420 430
....*....|....*....|....*....|...
gi 1034562211 558 WDIAKRVKPTGSILPPQLLNSPYLHDQKRKEQQ 590
Cdd:PTZ00110 490 RDLVKVLREAKQPVPPELEKLSNERSNGTERRR 522
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
214-405 |
2.99e-85 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 264.69 E-value: 2.99e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 214 LNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFES----KTPSALILTPTRELAIQIER 289
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPkkkgRGPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 290 QAKELMSGlPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLD 369
Cdd:cd00268 81 VARKLGKG-TGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDVEK 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 1034562211 370 ILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd00268 160 ILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
211-565 |
3.28e-78 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 255.50 E-value: 3.28e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 211 PEVLnHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPS------ALILTPTRELA 284
Cdd:PRK10590 10 PDIL-RAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKgrrpvrALILTPTRELA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 285 IQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQ 364
Cdd:PRK10590 89 AQIGENVRDYSKYL-NIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRMLDMGFI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 365 QQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVeDPAKKKKLFEILNDKKLFK 444
Cdd:PRK10590 168 HDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFV-DKKRKRELLSQMIGKGNWQ 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 445 pPVLVFVDCKLGADLLSEAVQKiTGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPS 524
Cdd:PRK10590 247 -QVLVFTRTKHGANHLAEQLNK-DGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPN 324
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1034562211 525 SMDEYVHQIGRVGRLGQNGTAITFINNNSKRLFWDIAKRVK 565
Cdd:PRK10590 325 VPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEKLLK 365
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
204-549 |
1.44e-75 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 247.55 E-value: 1.44e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 204 DFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRAL-FESKTPSA---LILTP 279
Cdd:PRK11192 2 TFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLdFPRRKSGPpriLILTP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 280 TRELAIQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTML 359
Cdd:PRK11192 82 TRELAMQVADQARELAKHT-HLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVETLILDEADRML 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 360 KMGFQQQVldilENIPNDC----QTILVSATIPTS-IEQLASQLLHNPVRIitgEKNLPCANVRQIILWVE--DPAKKKk 432
Cdd:PRK11192 161 DMGFAQDI----ETIAAETrwrkQTLLFSATLEGDaVQDFAERLLNDPVEV---EAEPSRRERKKIHQWYYraDDLEHK- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 433 lFEILndKKLFKPP----VLVFVDCKLGADLLSEAVQKiTGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRG 508
Cdd:PRK11192 233 -TALL--CHLLKQPevtrSIVFVRTRERVHELAGWLRK-AGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARG 308
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1034562211 509 LDLISVRLVVNFDMPSSMDEYVHQIGRVGRLGQNGTAITFI 549
Cdd:PRK11192 309 IDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLV 349
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
204-550 |
9.89e-75 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 246.25 E-value: 9.89e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 204 DFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMR---ALFEsktPSALILTPT 280
Cdd:PRK11776 5 AFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKldvKRFR---VQALVLCPT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 281 RELAIQIERQAKELMSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLK 360
Cdd:PRK11776 82 RELADQVAKEIRRLARFIPNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADRMLD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 361 MGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNlpcanvrqiilwvEDPAKKKKLFEILNDK 440
Cdd:PRK11776 162 MGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTH-------------DLPAIEQRFYEVSPDE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 441 KL---------FKP-PVLVF----VDCKLGADLLSEAvqkitGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLG 506
Cdd:PRK11776 229 RLpalqrlllhHQPeSCVVFcntkKECQEVADALNAQ-----GFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAA 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1034562211 507 RGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRLGQNGTAITFIN 550
Cdd:PRK11776 304 RGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVA 347
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
222-596 |
1.75e-70 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 239.75 E-value: 1.75e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 222 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRELAIQIERQAKELMSGLPRM 301
Cdd:PRK11634 25 GYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPTRELAVQVAEAMTDFSKHMRGV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 302 KTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIPNDCQTI 381
Cdd:PRK11634 105 NVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEMLRMGFIEDVETIMAQIPEGHQTA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 382 LVSATIPTSIEQLASQLLHNP--VRIITGEKNLPcaNVRQIILWVEDPAKKKKLFEILNDKKLfkPPVLVFVDCKLGADL 459
Cdd:PRK11634 185 LFSATMPEAIRRITRRFMKEPqeVRIQSSVTTRP--DISQSYWTVWGMRKNEALVRFLEAEDF--DAAIIFVRTKNATLE 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 460 LSEAVQKiTGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRL 539
Cdd:PRK11634 261 VAEALER-NGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRA 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1034562211 540 GQNGTAITFINNNSKRLFWDIAKRVKPTgsiLPPQLLNSPYLHDQKRKEQQKDKQTQ 596
Cdd:PRK11634 340 GRAGRALLFVENRERRLLRNIERTMKLT---IPEVELPNAELLGKRRLEKFAAKVQQ 393
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
205-401 |
6.08e-67 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 217.74 E-value: 6.08e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 205 FEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRaLFESK-----------TPS 273
Cdd:cd17967 2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISK-LLEDGppsvgrgrrkaYPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 274 ALILTPTRELAIQIERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVD 353
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYRSG-VRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVLD 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1034562211 354 EADTMLKMGFQQQVLDILE--NIP--NDCQTILVSATIPTSIEQLASQLLHN 401
Cdd:cd17967 160 EADRMLDMGFEPQIRKIVEhpDMPpkGERQTLMFSATFPREIQRLAADFLKN 211
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
200-548 |
5.21e-65 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 223.67 E-value: 5.21e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 200 RPIID--FEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMR-----ALFESK-- 270
Cdd:PRK04537 4 KPLTDltFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRllsrpALADRKpe 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 271 TPSALILTPTRELAIQIERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSV-ELCGVKI 349
Cdd:PRK04537 84 DPRALILAPTRELAIQIHKDAVKFGADLG-LRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVvSLHACEI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 350 VVVDEADTMLKMGFQQQVLDILENIPNDC--QTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVEDP 427
Cdd:PRK04537 163 CVLDEADRMFDLGFIKDIRFLLRRMPERGtrQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 428 AKKKKLFEILNDKKLFKppVLVFVDCKLGADLLSEAVQKiTGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGR 507
Cdd:PRK04537 243 EKQTLLLGLLSRSEGAR--TMVFVNTKAFVERVARTLER-HGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAAR 319
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1034562211 508 GLDLISVRLVVNFDMPSSMDEYVHQIGRVGRLGQNGTAITF 548
Cdd:PRK04537 320 GLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISF 360
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
222-405 |
1.25e-63 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 208.26 E-value: 1.25e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 222 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALF---ESKTPSALILTPTRELAIQIERQAKELMSGL 298
Cdd:cd17947 9 GFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYrpkKKAATRVLVLVPTRELAMQCFSVLQQLAQFT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 299 PrMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQS-SVELCGVKIVVVDEADTMLKMGFQQQVLDILENIPND 377
Cdd:cd17947 89 D-ITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSpSFDLDSIEILVLDEADRMLEEGFADELKEILRLCPRT 167
|
170 180
....*....|....*....|....*...
gi 1034562211 378 CQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17947 168 RQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
205-548 |
2.27e-62 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 214.01 E-value: 2.27e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 205 FEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESK-------TPSALIL 277
Cdd:PRK01297 89 FHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPpkerymgEPRALII 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 278 TPTRELAIQIERQAKELM--SGLPRMKtvlLVGGLPLPPQLYRLQ-QHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDE 354
Cdd:PRK01297 169 APTRELVVQIAKDAAALTkyTGLNVMT---FVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDE 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 355 ADTMLKMGFQQQVLDILENIP--NDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVEDPAKKKK 432
Cdd:PRK01297 246 ADRMLDMGFIPQVRQIIRQTPrkEERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVAGSDKYKL 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 433 LFEILNDKKLFKppVLVFVDCKLGADLLSEAVQKiTGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLI 512
Cdd:PRK01297 326 LYNLVTQNPWER--VMVFANRKDEVRRIEERLVK-DGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHID 402
|
330 340 350
....*....|....*....|....*....|....*.
gi 1034562211 513 SVRLVVNFDMPSSMDEYVHQIGRVGRLGQNGTAITF 548
Cdd:PRK01297 403 GISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISF 438
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
214-408 |
3.63e-61 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 201.66 E-value: 3.63e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 214 LNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMR--ALFESKTPSALILTPTRELAIQIERQA 291
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKlgKPRKKKGLRALILAPTRELASQIYREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 292 KELMSGLPrMKTVLLVGGL-PLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDI 370
Cdd:cd17957 81 LKLSKGTG-LRIVLLSKSLeAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQTDEI 159
|
170 180 190
....*....|....*....|....*....|....*....
gi 1034562211 371 LENIPNDC-QTILVSATIPTSIEQLASQLLHNPVRIITG 408
Cdd:cd17957 160 LAACTNPNlQRSLFSATIPSEVEELARSVMKDPIRIIVG 198
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
205-405 |
3.45e-59 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 196.76 E-value: 3.45e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 205 FEHCSL-PEVLNhNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPS--ALILTPTR 281
Cdd:cd17959 3 FQSMGLsPPLLR-AIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTVGarALILSPTR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 282 ELAIQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKM 361
Cdd:cd17959 82 ELALQTLKVTKELGKFT-DLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRLFEM 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1034562211 362 GFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17959 161 GFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
193-406 |
4.79e-59 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 196.83 E-value: 4.79e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 193 VQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI-----MRALF 267
Cdd:cd17953 2 VRGKDCPKPIQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFrhikdQRPVK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 268 ESKTPSALILTPTRELAIQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSS---VEL 344
Cdd:cd17953 82 PGEGPIGLIMAPTRELALQIYVECKKFSKAL-GLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANNgrvTNL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034562211 345 CGVKIVVVDEADTMLKMGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRII 406
Cdd:cd17953 161 RRVTYVVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEIT 222
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
205-562 |
1.30e-58 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 201.59 E-value: 1.30e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 205 FEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRELA 284
Cdd:PTZ00424 30 FDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 285 IQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQ 364
Cdd:PTZ00424 110 QQIQKVVLALGDYL-KVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRGFK 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 365 QQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVEdpaKKKKLFEILND--KKL 442
Cdd:PTZ00424 189 GQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVE---KEEWKFDTLCDlyETL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 443 FKPPVLVFVDCKLGADLLSEAVQKITGLKSiSIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDM 522
Cdd:PTZ00424 266 TITQAIIYCNTRRKVDYLTKKMHERDFTVS-CMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDL 344
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1034562211 523 PSSMDEYVHQIGRVGRLGQNGTAITFINNNSKRLFWDIAK 562
Cdd:PTZ00424 345 PASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIER 384
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
193-400 |
3.39e-58 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 196.34 E-value: 3.39e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 193 VQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRAL------ 266
Cdd:cd18052 33 VTGRNPPPAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMkeglta 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 267 ---FESKTPSALILTPTRELAIQIERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVE 343
Cdd:cd18052 113 ssfSEVQEPQALIVAPTRELANQIFLEARKFSYGTC-IRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKIS 191
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034562211 344 LCGVKIVVVDEADTMLKMGFQQQVLDILE--NIP--NDCQTILVSATIPTSIEQLASQLLH 400
Cdd:cd18052 192 LSKLKYLILDEADRMLDMGFGPEIRKLVSepGMPskEDRQTLMFSATFPEEIQRLAAEFLK 252
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
218-405 |
5.26e-57 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 191.38 E-value: 5.26e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMR-----ALFESKT---PSALILTPTRELAIQIER 289
Cdd:cd17945 5 IRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYisrlpPLDEETKddgPYALILAPTRELAQQIEE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 290 QAKELMSGLpRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLD 369
Cdd:cd17945 85 ETQKFAKPL-GIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEPQVTK 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1034562211 370 ILENIPNDC--------------------QTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17945 164 ILDAMPVSNkkpdteeaeklaasgkhryrQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
205-405 |
4.41e-55 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 185.60 E-value: 4.41e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 205 FEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPvIMRALFESKTP-SALILTPTREL 283
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALP-ILQALLENPQRfFALVLAPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 284 AIQIERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSS-VELCGVKIVVVDEADTMLKMG 362
Cdd:cd17954 81 AQQISEQFEALGSSIG-LKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKgFSLKSLKFLVMDEADRLLNMD 159
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1034562211 363 FQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17954 160 FEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKI 202
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
214-405 |
1.07e-53 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 181.84 E-value: 1.07e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 214 LNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIM-----RALFESKTPSALILTPTRELAIQIE 288
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVhimdqRELEKGEGPIAVIVAPTRELAQQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 289 RQAKELmSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVL 368
Cdd:cd17952 81 LEAKKF-GKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQVR 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 1034562211 369 DILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17952 160 SIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
227-394 |
1.72e-52 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 177.43 E-value: 1.72e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 227 TPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRELAIQIERQAKELMSGLpRMKTVLL 306
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGL-GLKVASL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 307 VGGLPLPPQLYRLqQHVKVIIATPGRLLDIIKQsSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIPNDCQTILVSAT 386
Cdd:pfam00270 80 LGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSAT 157
|
....*...
gi 1034562211 387 IPTSIEQL 394
Cdd:pfam00270 158 LPRNLEDL 165
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
218-399 |
5.22e-52 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 177.78 E-value: 5.22e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 218 LKKSGYEVPTPIQMQMIPVGL-LGRDILASADTGSGKTAAFLLPVIMRAL-----FESKTPSALILTPTRELAIQIERQA 291
Cdd:cd17964 9 LTRMGFETMTPVQQKTLKPILsTGDDVLARAKTGTGKTLAFLLPAIQSLLntkpaGRRSGVSALIISPTRELALQIAAEA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 292 KELMSGLPRMKTVLLVGGLPLPPQLYRLQ-QHVKVIIATPGRLLDIIKQSSV--ELCGVKIVVVDEADTMLKMGFQQQVL 368
Cdd:cd17964 89 KKLLQGLRKLRVQSAVGGTSRRAELNRLRrGRPDILVATPGRLIDHLENPGVakAFTDLDYLVLDEADRLLDMGFRPDLE 168
|
170 180 190
....*....|....*....|....*....|....*
gi 1034562211 369 DILENIPN----DCQTILVSATIPTSIEQLASQLL 399
Cdd:cd17964 169 QILRHLPEknadPRQTLLFSATVPDEVQQIARLTL 203
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
218-405 |
3.25e-51 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 175.25 E-value: 3.25e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRA-----LFESKTPSALILTPTRELAIQIERQAK 292
Cdd:cd17966 5 LKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHInaqppLERGDGPIVLVLAPTRELAQQIQQEAN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 293 ELmSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILE 372
Cdd:cd17966 85 KF-GGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQIRKIVD 163
|
170 180 190
....*....|....*....|....*....|...
gi 1034562211 373 NIPNDCQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17966 164 QIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
168-408 |
2.10e-49 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 172.89 E-value: 2.10e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 168 YKEHPFILNLQEDQIENLKQQLGILVQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASA 247
Cdd:cd18050 27 YVEHPEVARMTQYDVEELRRKKEITIRGVGCPKPVFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 248 DTGSGKTAAFLLPVIMRA-----LFESKTPSALILTPTRELAIQIERQAKELMSGlPRMKTVLLVGGLPLPPQLYRLQQH 322
Cdd:cd18050 107 QTGSGKTLAYLLPAIVHInhqpyLERGDGPICLVLAPTRELAQQVQQVADDYGKS-SRLKSTCIYGGAPKGPQIRDLERG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 323 VKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNP 402
Cdd:cd18050 186 VEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDY 265
|
....*.
gi 1034562211 403 VRIITG 408
Cdd:cd18050 266 VQINIG 271
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
195-401 |
2.55e-49 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 172.15 E-value: 2.55e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 195 GQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPvIMRALFES----- 269
Cdd:cd18051 13 GENCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLP-ILSQIYEQgpges 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 270 ------------KTPSALILTPTRELAIQIERQAKELmSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDII 337
Cdd:cd18051 92 lpsesgyygrrkQYPLALVLAPTRELASQIYDEARKF-AYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDML 170
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034562211 338 KQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILE--NIP--NDCQTILVSATIPTSIEQLASQLLHN 401
Cdd:cd18051 171 ERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEqdTMPptGERQTLMFSATFPKEIQMLARDFLDN 238
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
205-405 |
2.83e-49 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 170.17 E-value: 2.83e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 205 FEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRELA 284
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 285 IQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQ 364
Cdd:cd17940 81 LQTSQVCKELGKHM-GVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLSQDFQ 159
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1034562211 365 QQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17940 160 PIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
211-548 |
6.27e-49 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 176.32 E-value: 6.27e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 211 PEVLNhNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKT-------PSALILTPTREL 283
Cdd:PRK04837 17 PQVVE-ALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPedrkvnqPRALIMAPTREL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 284 AIQIERQAKEL--MSGLprmKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKM 361
Cdd:PRK04837 96 AVQIHADAEPLaqATGL---KLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMFDL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 362 GFQQQVLDILENIPNDCQ--TILVSATIPTSIEQLASQLLHNPVRII------TGEknlpcaNVRQIILWVEDPAKKKKL 433
Cdd:PRK04837 173 GFIKDIRWLFRRMPPANQrlNMLFSATLSYRVRELAFEHMNNPEYVEvepeqkTGH------RIKEELFYPSNEEKMRLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 434 FEILN----DKklfkppVLVFVDCK---------LGADllSEAVQKITGlksisihsEKSQIERKNILKGLLEGDYEVVV 500
Cdd:PRK04837 247 QTLIEeewpDR------AIIFANTKhrceeiwghLAAD--GHRVGLLTG--------DVAQKKRLRILEEFTRGDLDILV 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1034562211 501 STGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRLGQNGTAITF 548
Cdd:PRK04837 311 ATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
218-405 |
1.35e-48 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 168.24 E-value: 1.35e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPS----ALILTPTRELAIQIERQAKE 293
Cdd:cd17941 5 LKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEdglgALIISPTRELAMQIFEVLRK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 294 LMSGlPRMKTVLLVGGLPLPPQLYRLQQhVKVIIATPGRLLDIIKQS-SVELCGVKIVVVDEADTMLKMGFQQQVLDILE 372
Cdd:cd17941 85 VGKY-HSFSAGLIIGGKDVKEEKERINR-MNILVCTPGRLLQHMDETpGFDTSNLQMLVLDEADRILDMGFKETLDAIVE 162
|
170 180 190
....*....|....*....|....*....|...
gi 1034562211 373 NIPNDCQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17941 163 NLPKSRQTLLFSATQTKSVKDLARLSLKNPEYI 195
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
218-413 |
1.59e-48 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 168.05 E-value: 1.59e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 218 LKKSGYEVPTPIQMQMIPVGLLG-RDILASADTGSGKTAAFLLPvIMRALFESKTPSALILTPTRELAIQIERQAKELMS 296
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLP-ALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 297 GLPRmKTVLLVGGLPLPPQLYRLQQHV-KVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIP 375
Cdd:smart00487 80 SLGL-KVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLP 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 1034562211 376 NDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNLP 413
Cdd:smart00487 159 KNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLE 196
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
218-405 |
1.63e-48 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 168.29 E-value: 1.63e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKT--------PSALILTPTRELAIQ--- 286
Cdd:cd17951 5 LKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKlpfikgegPYGLIVCPSRELARQthe 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 287 -IERQAKELM-SGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQ 364
Cdd:cd17951 85 vIEYYCKALQeGGYPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMIDMGFE 164
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1034562211 365 QQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17951 165 EDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
181-408 |
3.41e-48 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 168.65 E-value: 3.41e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 181 QIENLKQQLGILVQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLP 260
Cdd:cd18049 2 EVEQYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 261 VIMRA-----LFESKTPSALILTPTRELAIQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLD 335
Cdd:cd18049 82 AIVHInhqpfLERGDGPICLVLAPTRELAQQVQQVAAEYGRAC-RLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLID 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034562211 336 IIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIITG 408
Cdd:cd18049 161 FLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIG 233
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
205-403 |
3.69e-47 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 164.70 E-value: 3.69e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 205 FEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRAlfeSKTPS---ALILTPTR 281
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL---SEDPYgifALVLTPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 282 ELAIQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCG---VKIVVVDEADTM 358
Cdd:cd17955 78 ELAYQIAEQFRALGAPL-GLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSDDTTKVlsrVKFLVLDEADRL 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1034562211 359 LKMGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPV 403
Cdd:cd17955 157 LTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
218-403 |
4.60e-47 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 164.29 E-value: 4.60e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKT------PSALILTPTRELAIQIERQA 291
Cdd:cd17961 9 IAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAEsgeeqgTRALILVPTRELAQQVSKVL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 292 KELMSGL-PRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELC-GVKIVVVDEADTMLKMGFQQQVLD 369
Cdd:cd17961 89 EQLTAYCrKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLsTLKYLVIDEADLVLSYGYEEDLKS 168
|
170 180 190
....*....|....*....|....*....|....
gi 1034562211 370 ILENIPNDCQTILVSATIPTSIEQLASQLLHNPV 403
Cdd:cd17961 169 LLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPA 202
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
217-405 |
9.70e-46 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 160.32 E-value: 9.70e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 217 NLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKT------PSALILTPTRELAIQIERQ 290
Cdd:cd17958 4 EIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPreqrngPGVLVLTPTRELALQIEAE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 291 -AKELMSGlprMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLD 369
Cdd:cd17958 84 cSKYSYKG---LKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQIRK 160
|
170 180 190
....*....|....*....|....*....|....*.
gi 1034562211 370 ILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17958 161 ILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
222-406 |
1.09e-45 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 160.57 E-value: 1.09e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 222 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRELAIQIERQAKELMSGLpRM 301
Cdd:cd17939 16 GFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQIQKVVKALGDYM-GV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 302 KTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIPNDCQTI 381
Cdd:cd17939 95 KVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRGFKDQIYDIFQFLPPETQVV 174
|
170 180
....*....|....*....|....*
gi 1034562211 382 LVSATIPTSIEQLASQLLHNPVRII 406
Cdd:cd17939 175 LFSATMPHEVLEVTKKFMRDPVRIL 199
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
218-405 |
2.82e-44 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 156.27 E-value: 2.82e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRELAIQIERQAKELMSG 297
Cdd:cd17943 5 LKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKKIGKK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 298 LPRMKTVLLVGGLPLPPQLYRLQQhVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIPND 377
Cdd:cd17943 85 LEGLKCEVFIGGTPVKEDKKKLKG-CHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNWIFSSLPKN 163
|
170 180
....*....|....*....|....*...
gi 1034562211 378 CQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17943 164 KQVIAFSATYPKNLDNLLARYMRKPVLV 191
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
222-403 |
6.56e-43 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 152.86 E-value: 6.56e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 222 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVImralfesKTPSALILTPTRELAIQ----IERQAKELMSg 297
Cdd:cd17938 18 DWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVL-------QIVVALILEPSRELAEQtyncIENFKKYLDN- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 298 lPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIP-- 375
Cdd:cd17938 90 -PKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLSQGNLETINRIYNRIPki 168
|
170 180 190
....*....|....*....|....*....|...
gi 1034562211 376 ----NDCQTILVSATI-PTSIEQLASQLLHNPV 403
Cdd:cd17938 169 tsdgKRLQVIVCSATLhSFEVKKLADKIMHFPT 201
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
218-405 |
3.61e-42 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 150.80 E-value: 3.61e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI-----MRALFESKTPSALILTPTRELAIQIERQAK 292
Cdd:cd17960 5 VAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLeillkRKANLKKGQVGALIISPTRELATQIYEVLQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 293 ELMS-GLPRMKTVLLVGGLPLPPQLYRLQQH-VKVIIATPGRLLDIIKQSSVELCG--VKIVVVDEADTMLKMGFQQQVL 368
Cdd:cd17960 85 SFLEhHLPKLKCQLLIGGTNVEEDVKKFKRNgPNILVGTPGRLEELLSRKADKVKVksLEVLVLDEADRLLDLGFEADLN 164
|
170 180 190
....*....|....*....|....*....|....*..
gi 1034562211 369 DILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17960 165 RILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRV 201
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
417-549 |
6.21e-42 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 147.65 E-value: 6.21e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 417 VRQIILWVEDPAKKKKLFEILnDKKLFKPPVLVFVDCKLGADLLSEAVQKItGLKSISIHSEKSQIERKNILKGLLEGDY 496
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLL-LEKLKPGKAIIFVNTKKRVDRLAELLEEL-GIKVAALHGDLSQEERERALKKFRSGKV 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1034562211 497 EVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRLGQNGTAITFI 549
Cdd:cd18787 79 RVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
219-405 |
6.79e-41 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 147.73 E-value: 6.79e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 219 KKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALfeSKTPS--------ALILTPTRELAIQIERQ 290
Cdd:cd17949 7 SKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLL--SLEPRvdrsdgtlALVLVPTRELALQIYEV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 291 AKELMSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQ-SSVELCGVKIVVVDEADTMLKMGFQQQVLD 369
Cdd:cd17949 85 LEKLLKPFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNtQSFDVSNLRWLVLDEADRLLDMGFEKDITK 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1034562211 370 ILE-------------NIPNDCQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17949 165 ILEllddkrskaggekSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
218-395 |
6.40e-40 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 144.81 E-value: 6.40e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 218 LKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLP---VIMRALFESKTPSA-LILTPTRELAIQIERQAKE 293
Cdd:cd17942 5 IEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPaieLLYKLKFKPRNGTGvIIISPTRELALQIYGVAKE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 294 LMSGlpRMKTVLLV-GGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELC-GVKIVVVDEADTMLKMGFQQQVLDIL 371
Cdd:cd17942 85 LLKY--HSQTFGIViGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLYkNLQCLIIDEADRILEIGFEEEMRQII 162
|
170 180
....*....|....*....|....
gi 1034562211 372 ENIPNDCQTILVSATIPTSIEQLA 395
Cdd:cd17942 163 KLLPKRRQTMLFSATQTRKVEDLA 186
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
218-387 |
2.56e-39 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 144.30 E-value: 2.56e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 218 LKKSGYEVPTPIQMQMIPVGLL-GRDILASADTGSGKTAAFLLPVIMRAL---------FESKTPSALILTPTRELAIQI 287
Cdd:cd17946 5 LADLGFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILERLLsqkssngvgGKQKPLRALILTPTRELAVQV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 288 ERQAKELMSGlPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIV---VVDEADTMLKMGFQ 364
Cdd:cd17946 85 KDHLKAIAKY-TNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHLANLKSLrflVLDEADRMLEKGHF 163
|
170 180 190
....*....|....*....|....*....|
gi 1034562211 365 QQVLDILENIPNDC-------QTILVSATI 387
Cdd:cd17946 164 AELEKILELLNKDRagkkrkrQTFVFSATL 193
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
205-406 |
8.97e-39 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 141.45 E-value: 8.97e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 205 FEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRELA 284
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 285 IQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQ 364
Cdd:cd18045 81 VQIQKVLLALGDYM-NVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNKGFK 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1034562211 365 QQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRII 406
Cdd:cd18045 160 EQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRIL 201
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
205-406 |
2.03e-38 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 140.66 E-value: 2.03e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 205 FEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRELA 284
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 285 IQIERQAKELMSGLpRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQ 364
Cdd:cd18046 81 QQIQKVVMALGDYM-GIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSRGFK 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1034562211 365 QQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRII 406
Cdd:cd18046 160 DQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRIL 201
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
214-397 |
1.56e-34 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 130.95 E-value: 1.56e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 214 LNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFES-------KTPSALILTPTRELAIQ 286
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKllaegpfNAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 287 IERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQ 366
Cdd:cd17948 81 IGSVAQSLTEGLG-LKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNEK 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1034562211 367 VLDILENIP-------------NDCQTILVSATIPTSIEQLASQ 397
Cdd:cd17948 160 LSHFLRRFPlasrrsentdgldPGTQLVLVSATMPSGVGEVLSK 203
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
211-405 |
1.92e-32 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 124.38 E-value: 1.92e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 211 PEVLNhNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRELAIQIERQ 290
Cdd:cd17950 11 PELLR-AIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTRELAFQISNE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 291 AKELMSGLPRMKTVLLVGGLPLPPQLYRLQ-QHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLK-MGFQQQVL 368
Cdd:cd17950 90 YERFSKYMPNVKTAVFFGGVPIKKDIEVLKnKCPHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLEqLDMRRDVQ 169
|
170 180 190
....*....|....*....|....*....|....*..
gi 1034562211 369 DILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17950 170 EIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEI 206
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
211-405 |
4.95e-32 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 122.68 E-value: 4.95e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 211 PEVLNHnLKKSGYEVPTPIQMQMIPVgLLG---RDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRELAIQI 287
Cdd:cd17963 3 PELLKG-LYAMGFNKPSKIQETALPL-ILSdppENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 288 ERQAKELMSgLPRMKTVLLVGGLPLPPQlYRLQQHvkVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKM-GFQQQ 366
Cdd:cd17963 81 GEVVEKMGK-FTGVKVALAVPGNDVPRG-KKITAQ--IVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTqGHGDQ 156
|
170 180 190
....*....|....*....|....*....|....*....
gi 1034562211 367 VLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRI 405
Cdd:cd17963 157 SIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
217-402 |
1.68e-30 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 119.27 E-value: 1.68e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 217 NLKKSGYEVPTPIQMQMIP---------VGLLGRDILASADTGSGKTAAFLLPVImRALFESKTPS--ALILTPTRELAI 285
Cdd:cd17956 4 NLQNNGITSAFPVQAAVIPwllpsskstPPYRPGDLCVSAPTGSGKTLAYVLPIV-QALSKRVVPRlrALIVVPTKELVQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 286 QIERQAKELMSGLPrMKTVLLVGG------LPLPPQLYRLQQHVKV--IIATPGRLLDIIKQ-SSVELCGVKIVVVDEAD 356
Cdd:cd17956 83 QVYKVFESLCKGTG-LKVVSLSGQksfkkeQKLLLVDTSGRYLSRVdiLVATPGRLVDHLNStPGFTLKHLRFLVIDEAD 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034562211 357 TMLKMGFQQ---QVLDILENIPND-----------------CQTILVSATIPTSIEQLASQLLHNP 402
Cdd:cd17956 162 RLLNQSFQDwleTVMKALGRPTAPdlgsfgdanllersvrpLQKLLFSATLTRDPEKLSSLKLHRP 227
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
217-399 |
8.83e-30 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 116.49 E-value: 8.83e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 217 NLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMR------ALFESKTPSALILTPTRELAIQIerq 290
Cdd:cd17944 4 LLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKlqedqqPRKRGRAPKVLVLAPTRELANQV--- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 291 AKELMSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDI 370
Cdd:cd17944 81 TKDFKDITRKLSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEEI 160
|
170 180 190
....*....|....*....|....*....|....
gi 1034562211 371 L-----ENIPNDCQTILVSATIPTSIEQLASQLL 399
Cdd:cd17944 161 LsvsykKDSEDNPQTLLFSATCPDWVYNVAKKYM 194
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
428-540 |
2.63e-23 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 94.97 E-value: 2.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 428 AKKKKLFEILNDKKlfKPPVLVFvdCKLGADLLSEAVQKITGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGR 507
Cdd:pfam00271 1 EKLEALLELLKKER--GGKVLIF--SQTKKTLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAER 76
|
90 100 110
....*....|....*....|....*....|...
gi 1034562211 508 GLDLISVRLVVNFDMPSSMDEYVHQIGRVGRLG 540
Cdd:pfam00271 77 GLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
205-402 |
6.76e-23 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 97.78 E-value: 6.76e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 205 FEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLG--RDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRE 282
Cdd:cd18048 20 FEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQCLCLSPTFE 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 283 LAIQIERQAKELMSGLPRMKTVLLVGGlPLPPQLYRLQQhvKVIIATPGRLLD-IIKQSSVELCGVKIVVVDEADTMLKM 361
Cdd:cd18048 100 LALQTGKVVEEMGKFCVGIQVIYAIRG-NRPGKGTDIEA--QIVIGTPGTVLDwCFKLRLIDVTNISVFVLDEADVMINV 176
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1034562211 362 -GFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNP 402
Cdd:cd18048 177 qGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDP 218
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
458-540 |
1.97e-21 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 88.42 E-value: 1.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 458 DLLSEAVQKItGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVG 537
Cdd:smart00490 1 EELAELLKEL-GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAG 79
|
...
gi 1034562211 538 RLG 540
Cdd:smart00490 80 RAG 82
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
212-407 |
3.37e-20 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 90.51 E-value: 3.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 212 EVLNHNLKKSGYEVPTPIQMQMIPVgLLGRDI-----------------LASADTGSGKTAAFLLPvIMRALFE------ 268
Cdd:cd17965 17 EILKGSNKTDEEIKPSPIQTLAIKK-LLKTLMrkvtkqtsneepklevfLLAAETGSGKTLAYLAP-LLDYLKRqeqepf 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 269 ------------SKTPSALILTPTRELAIQIERQAKELMSGLP-RMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLD 335
Cdd:cd17965 95 eeaeeeyesakdTGRPRSVILVPTHELVEQVYSVLKKLSHTVKlGIKTFSSGFGPSYQRLQLAFKGRIDILVTTPGKLAS 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034562211 336 IIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIIT 407
Cdd:cd17965 175 LAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKEFDKTLRKLFPDVVRIAT 246
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
205-402 |
1.74e-19 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 87.08 E-value: 1.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 205 FEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLG--RDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRE 282
Cdd:cd18047 3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 283 LAIQIERQAKELMSGLPRMKTVLLVGGlplppqlYRLQQHVK----VIIATPGRLLD-IIKQSSVELCGVKIVVVDEADT 357
Cdd:cd18047 83 LALQTGKVIEQMGKFYPELKLAYAVRG-------NKLERGQKiseqIVIGTPGTVLDwCSKLKFIDPKKIKVFVLDEADV 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1034562211 358 ML-KMGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNP 402
Cdd:cd18047 156 MIaTQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
240-566 |
1.72e-18 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 89.31 E-value: 1.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 240 GRDILASADTGSGKTAAFLLpvIMRALFESKTpsALILTPTRELAIQIerqAKELMSGLPRmktVLLVGGlplppqlyRL 319
Cdd:COG1061 100 GGRGLVVAPTGTGKTVLALA--LAAELLRGKR--VLVLVPRRELLEQW---AEELRRFLGD---PLAGGG--------KK 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 320 QQHVKVIIATPGRLldiIKQSSVELCG--VKIVVVDE-----ADTmlkmgFQQqvldILENIPNDCqTILVSAT------ 386
Cdd:COG1061 162 DSDAPITVATYQSL---ARRAHLDELGdrFGLVIIDEahhagAPS-----YRR----ILEAFPAAY-RLGLTATpfrsdg 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 387 --IPTSI-----------EQLASQLLHNPVRII--------TGEKNLPCANVRQIILwVEDPAKKKKLFEILnDKKLFKP 445
Cdd:COG1061 229 reILLFLfdgivyeyslkEAIEDGYLAPPEYYGirvdltdeRAEYDALSERLREALA-ADAERKDKILRELL-REHPDDR 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 446 PVLVFVDCKLGADLLSEAVQKItGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSS 525
Cdd:COG1061 307 KTLVFCSSVDHAEALAELLNEA-GIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGS 385
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1034562211 526 MDEYVHQIGRVGRLGQNGTAITFIN--NNSKRLFWDIAKRVKP 566
Cdd:COG1061 386 PREFIQRLGRGLRPAPGKEDALVYDfvGNDVPVLEELAKDLRD 428
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
240-386 |
1.31e-17 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 79.75 E-value: 1.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 240 GRDILASADTGSGKTAAFLLpvIMRALFESKTPSALILTPTRELAIQierQAKELMSGLPRMKTV-LLVGGLPLPPQLYR 318
Cdd:cd00046 1 GENVLITAPTGSGKTLAALL--AALLLLLKKGKKVLVLVPTKALALQ---TAERLRELFGPGIRVaVLVGGSSAEEREKN 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034562211 319 LQQHVKVIIATPGRLLDIIKQS-SVELCGVKIVVVDEADTMLKMGFQ--QQVLDILENIPNDCQTILVSAT 386
Cdd:cd00046 76 KLGDADIIIATPDMLLNLLLREdRLFLKDLKLIIVDEAHALLIDSRGalILDLAVRKAGLKNAQVILLSAT 146
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
240-557 |
4.58e-17 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 85.27 E-value: 4.58e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 240 GRDILASADTGSGKTAAFLLPVImRALFESKTPSALILTPTRELAI-QIERQAKELMSGLPRMKTVLLVGGLPlPPQLYR 318
Cdd:COG1205 71 GKNVVIATPTASGKSLAYLLPVL-EALLEDPGATALYLYPTKALARdQLRRLRELAEALGLGVRVATYDGDTP-PEERRW 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 319 LQQHVKVIIATPgrllDIIKQSSVE--------LCGVKIVVVDEADT-----------MLKmgfqqQVLDILENIPNDCQ 379
Cdd:COG1205 149 IREHPDIVLTNP----DMLHYGLLPhhtrwarfFRNLRYVVIDEAHTyrgvfgshvanVLR-----RLRRICRHYGSDPQ 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 380 TILVSATI--PtsiEQLASQLLHNPVRIIT------GEknlpcanvRQIILW----VEDPAKK------KKLFEILNDKK 441
Cdd:COG1205 220 FILASATIgnP---AEHAERLTGRPVTVVDedgsprGE--------RTFVLWnpplVDDGIRRsalaeaARLLADLVREG 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 442 LfkpPVLVFVDCKLGADLLSEAVQK--ITGLKSISIHSEKSQI---ERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRL 516
Cdd:COG1205 289 L---RTLVFTRSRRGAELLARYARRalREPDLADRVAAYRAGYlpeERREIERGLRSGELLGVVSTNALELGIDIGGLDA 365
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1034562211 517 VVNFDMPSSMDEYVHQIGRVGRLGQNGTAI---------TFINNNSKRLF 557
Cdd:COG1205 366 VVLAGYPGTRASFWQQAGRAGRRGQDSLVVlvagddpldQYYVRHPEELF 415
|
|
| zf-HIT_DDX59 |
cd23022 |
zinc finger HIT (zf-HIT) found in DEAD box protein 59 (DDX59) and similar proteins; DDX59, ... |
103-136 |
6.09e-17 |
|
zinc finger HIT (zf-HIT) found in DEAD box protein 59 (DDX59) and similar proteins; DDX59, also called zinc finger HIT domain-containing protein 5 (ZNHIT5), is a probable ATP-dependent RNA helicase (EC 3.6.4.13) that plays a role in nervous system development and function. It has an important role in lung cancer development through promoting DNA replication. Mutations in DDX59 implicate RNA helicase in the pathogenesis of oral-facial-digital syndrome (OFDS). DDX59 contains a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC zinc finger motifs that both bind a zinc ion.
Pssm-ID: 467794 Cd Length: 35 Bit Score: 74.20 E-value: 6.09e-17
10 20 30
....*....|....*....|....*....|....
gi 1034562211 103 PGEPICVVCGRYGEYICDKTDEDVCSLECKAKHL 136
Cdd:cd23022 1 GKEGWCVVCGRYANYYCDDTDDPVCSLECKRKHL 34
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
209-546 |
8.94e-14 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 74.16 E-value: 8.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 209 SLPEVLNHnLKKSGYEVPTPIQMQMIPVGLL-GRDILASADTGSGKTA-AFLLpvIMRALFESKTpsALILTPTRELAIQ 286
Cdd:COG1204 7 PLEKVIEF-LKERGIEELYPPQAEALEAGLLeGKNLVVSAPTASGKTLiAELA--ILKALLNGGK--ALYIVPLRALASE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 287 IERQAKELMSGLPrMKTVLLVGGLPLPPqlYRLQQHvKVIIATPGRLLDIIKQSSVELCGVKIVVVDEAdtmlkmgfqQQ 366
Cdd:COG1204 82 KYREFKRDFEELG-IKVGVSTGDYDSDD--EWLGRY-DILVATPEKLDSLLRNGPSWLRDVDLVVVDEA---------HL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 367 VLD-----ILENI-------PNDCQTILVSATIPtSIEQLAsQLLHN--------PVRIITGeknlpcANVRQIILWVED 426
Cdd:COG1204 149 IDDesrgpTLEVLlarlrrlNPEAQIVALSATIG-NAEEIA-EWLDAelvksdwrPVPLNEG------VLYDGVLRFDDG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 427 PAK-KKKLFEILNDKKLFKPPVLVFV----DCKLGADLLSEAVQKITGLK--------SISIHSEK-------------- 479
Cdd:COG1204 221 SRRsKDPTLALALDLLEEGGQVLVFVssrrDAESLAKKLADELKRRLTPEereeleelAEELLEVSeethtnekladcle 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 480 ----------SQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVV-----NFDMP-SSMDeyVHQ-IGRVGRLGQN 542
Cdd:COG1204 301 kgvafhhaglPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIrdtkrGGMVPiPVLE--FKQmAGRAGRPGYD 378
|
....*.
gi 1034562211 543 --GTAI 546
Cdd:COG1204 379 pyGEAI 384
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
227-388 |
4.89e-11 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 61.89 E-value: 4.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 227 TPIQMQMIPVGLL-GRDILASADTGSGKTAAFLLpVIMRALFESKtPSALILTPTRELAIQIERQAKELMSglPRMKTVL 305
Cdd:cd17921 3 NPIQREALRALYLsGDSVLVSAPTSSGKTLIAEL-AILRALATSG-GKAVYIAPTRALVNQKEADLRERFG--PLGKNVG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 306 LVGGLP--LPPQLYRLQqhvkVIIATPGRLLDIIKQSSVELCG-VKIVVVDEADtMLKMGFQ----QQVLDILENIPNDC 378
Cdd:cd17921 79 LLTGDPsvNKLLLAEAD----ILVATPEKLDLLLRNGGERLIQdVRLVVVDEAH-LIGDGERgvvlELLLSRLLRINKNA 153
|
170
....*....|
gi 1034562211 379 QTILVSATIP 388
Cdd:cd17921 154 RFVGLSATLP 163
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
240-398 |
3.21e-10 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 59.52 E-value: 3.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 240 GRDILASADTGSGKTAAFLLPvIMRALFESKTPSALILTPTRELAI-QIERQAKELMSGLPRMKTVLLVGGLPLPPQLYR 318
Cdd:cd17923 15 GRSVVVTTGTASGKSLCYQLP-ILEALLRDPGSRALYLYPTKALAQdQLRSLRELLEQLGLGIRVATYDGDTPREERRAI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 319 LQQHVKVIIATPGRL-LDIIKQSSVE---LCGVKIVVVDEADTmLKMGFQQQV-------LDILENIPNDCQTILVSATI 387
Cdd:cd17923 94 IRNPPRILLTNPDMLhYALLPHHDRWarfLRNLRYVVLDEAHT-YRGVFGSHValllrrlRRLCRRYGADPQFILTSATI 172
|
170
....*....|.
gi 1034562211 388 pTSIEQLASQL 398
Cdd:cd17923 173 -GNPAEHARTL 182
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
496-549 |
5.76e-10 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 55.79 E-value: 5.76e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1034562211 496 YEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRLGQ-NGTAITFI 549
Cdd:cd18785 23 LEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKdEGEVILFV 77
|
|
| zf-HIT |
cd23020 |
zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain ... |
107-136 |
1.33e-09 |
|
zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain with about 50 amino acids. It is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC zinc finger motifs that both bind a zinc ion. zf-HIT domain may function as a protein-protein interaction domain. It is mainly found in nuclear proteins involved in gene regulation and chromatin remodeling. The zf-HIT family includes six proteins containing zf-HIT domain present in human and three in yeast proteome, all belonging to multimodular RNA/protein complexes.
Pssm-ID: 467792 Cd Length: 31 Bit Score: 53.66 E-value: 1.33e-09
10 20 30
....*....|....*....|....*....|.
gi 1034562211 107 ICVVCGRY-GEYICDKTDEDVCSLECKAKHL 136
Cdd:cd23020 1 TCGICGGYpGKYKCPRCGVPYCSLECYRKHL 31
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
240-387 |
1.76e-08 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 54.13 E-value: 1.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 240 GRDILASADTGSGKTAAFLLPVIMRALFESKTPSALI-LTPTRELAIQIERqakelmsglpRMKTVLLVGGLPLP----- 313
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEKGVQVLyISPLKALINDQER----------RLEEPLDEIDLEIPvavrh 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 314 ---PQLYRLQQHVK---VIIATPGRL--LDIIKQSSVELCGVKIVVVDEADTML--KMGFQ-QQVLDILENIP-NDCQTI 381
Cdd:cd17922 71 gdtSQSEKAKQLKNppgILITTPESLelLLVNKKLRELFAGLRYVVVDEIHALLgsKRGVQlELLLERLRKLTgRPLRRI 150
|
....*.
gi 1034562211 382 LVSATI 387
Cdd:cd17922 151 GLSATL 156
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
319-548 |
1.91e-08 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 57.07 E-value: 1.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 319 LQQHVKVIIATPGRL-----LDIIKQSSVELcgvkiVVVDEA--------D-----TMLKmgfqqQVLDILENIPndcqT 380
Cdd:COG0514 104 RAGELKLLYVAPERLlnprfLELLRRLKISL-----FAIDEAhcisqwghDfrpdyRRLG-----ELRERLPNVP----V 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 381 ILVSAT-IPTSIEQLASQL-LHNPVRIITG--EKNLpcaNVRQIILWVEDpaKKKKLFEILndKKLFKPPVLVFV----D 452
Cdd:COG0514 170 LALTATaTPRVRADIAEQLgLEDPRVFVGSfdRPNL---RLEVVPKPPDD--KLAQLLDFL--KEHPGGSGIVYClsrkK 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 453 CKLGADLLSEAvqkitGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQ 532
Cdd:COG0514 243 VEELAEWLREA-----GIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGIDKPDVRFVIHYDLPKSIEAYYQE 317
|
250
....*....|....*.
gi 1034562211 533 IGRVGRLGQNGTAITF 548
Cdd:COG0514 318 IGRAGRDGLPAEALLL 333
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
457-548 |
3.65e-08 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 52.60 E-value: 3.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 457 ADLLSEAVQKItGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRV 536
Cdd:cd18794 43 CEQVAARLQSK-GISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRA 121
|
90
....*....|..
gi 1034562211 537 GRLGQNGTAITF 548
Cdd:cd18794 122 GRDGLPSECILF 133
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
223-408 |
1.28e-07 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 54.72 E-value: 1.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 223 YEVPTPIQMQMIPVGLLGRDILASADTGSGKT-AAFlLPVIMRaLFESKTPSAL-----IL--TPTRELAIQIERQAKEL 294
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGESTLLIAPTGSGKTlAAF-LPALDE-LARRPRPGELpdglrVLyiSPLKALANDIERNLRAP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 295 MSGLprmktvLLVGGLPLP-----------PQLYRLQQ-----HvkVIIATP-----------GRLLdiikqssveLCGV 347
Cdd:COG1201 100 LEEI------GEAAGLPLPeirvgvrtgdtPASERQRQrrrppH--ILITTPeslallltspdAREL---------LRGV 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034562211 348 KIVVVDE----ADTmlKMGFQQQV-LDILENI-PNDCQTILVSATI-PtsIEQLASQLLHN----PVRIITG 408
Cdd:COG1201 163 RTVIVDEihalAGS--KRGVHLALsLERLRALaPRPLQRIGLSATVgP--LEEVARFLVGYedprPVTIVDA 230
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
241-399 |
4.69e-07 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 50.49 E-value: 4.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 241 RDILASADTGSGKTAAFLLPVIMRAlfeSKTPSALILTPTRELAIQIERQAKELmsgLPRMKTVLLVGGlplppQLYRLQ 320
Cdd:cd17918 37 MDRLLSGDVGSGKTLVALGAALLAY---KNGKQVAILVPTEILAHQHYEEARKF---LPFINVELVTGG-----TKAQIL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 321 QHVKVIIATPGRLldiikQSSVELCGVKIVVVDEADtmlKMGFQQQvlDILENIPNdCQTILVSAT-IPTSIEQLASQLL 399
Cdd:cd17918 106 SGISLLVGTHALL-----HLDVKFKNLDLVIVDEQH---RFGVAQR--EALYNLGA-THFLEATATpIPRTLALALSGLL 174
|
|
| zf-HIT |
pfam04438 |
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could ... |
105-132 |
1.05e-06 |
|
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) that specifically interact with the ligand binding domain of the thyroid receptor.
Pssm-ID: 461310 Cd Length: 30 Bit Score: 45.32 E-value: 1.05e-06
10 20
....*....|....*....|....*...
gi 1034562211 105 EPICVVCGRYGEYICDKTDEDVCSLECK 132
Cdd:pfam04438 2 RKLCSVCGNPSKYRCPRCGVRYCSLECY 29
|
|
| SF2_C_UvrB |
cd18790 |
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) ... |
447-546 |
1.13e-06 |
|
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II), and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA. Its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350177 [Multi-domain] Cd Length: 171 Bit Score: 49.17 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 447 VLVFVDCKLGADLLSEAVQKItGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFD----- 521
Cdd:cd18790 30 VLVTTLTKRMAEDLTEYLQEL-GVKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVAILDadkeg 108
|
90 100
....*....|....*....|....*
gi 1034562211 522 MPSSMDEYVHQIGRVGRlGQNGTAI 546
Cdd:cd18790 109 FLRSETSLIQTIGRAAR-NVNGKVI 132
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
477-541 |
3.49e-06 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 50.11 E-value: 3.49e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034562211 477 SEKSQIErknILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFD-MPSSMdEYVHQIGRVGRLGQ 541
Cdd:COG1111 396 TQKEQIE---ILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEpVPSEI-RSIQRKGRTGRKRE 457
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
428-541 |
5.06e-06 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 46.32 E-value: 5.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 428 AKKKKLFEILndKKLFKPP--VLVFVDCKLGADLLSEAVQKItGLKSISIHSEKSQIERKNILKGLLEGDYEVV--VSTG 503
Cdd:cd18793 11 GKLEALLELL--EELREPGekVLIFSQFTDTLDILEEALRER-GIKYLRLDGSTSSKERQKLVDRFNEDPDIRVflLSTK 87
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1034562211 504 VLGRGLDLISVRLVVNFDMP--SSMDEyvhQ-IGRVGRLGQ 541
Cdd:cd18793 88 AGGVGLNLTAANRVILYDPWwnPAVEE---QaIDRAHRIGQ 125
|
|
| uvrb |
TIGR00631 |
excinuclease ABC, B subunit; All proteins in this family for wich functions are known are DNA ... |
378-554 |
5.14e-06 |
|
excinuclease ABC, B subunit; All proteins in this family for wich functions are known are DNA helicases that function in the nucleotide excision repair and are endonucleases that make the 3' incision next to DNA damage. They are part of a pathway requiring UvrA, UvrB, UvrC, and UvrD homologs. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University) [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273185 [Multi-domain] Cd Length: 655 Bit Score: 49.60 E-value: 5.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 378 CQTILVSATiPTSIE-QLASQLLHNPVRIiTGEKNlPCANVRQIILWVEDpakkkkLFEILNDKKLFKPPVLVFVDCKLG 456
Cdd:TIGR00631 384 NQVVYVSAT-PGPYElEQSGNVVEQIIRP-TGLLD-PEIEVRPTDGQVDD------LLSEIRQRVARNERVLVTTLTKKM 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 457 A----DLLSEAvqkitGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFD-----MPSSMD 527
Cdd:TIGR00631 455 AedltDYLKEL-----GIKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVAILDadkegFLRSER 529
|
170 180
....*....|....*....|....*..
gi 1034562211 528 EYVHQIGRVGRlGQNGTAITFINNNSK 554
Cdd:TIGR00631 530 SLIQTIGRAAR-NVNGKVIMYADKITD 555
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
460-548 |
2.06e-05 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 47.40 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 460 LSEAVQKiTGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRL 539
Cdd:PRK11057 252 TAARLQS-RGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRD 330
|
....*....
gi 1034562211 540 GQNGTAITF 548
Cdd:PRK11057 331 GLPAEAMLF 339
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
429-535 |
7.82e-05 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 42.96 E-value: 7.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 429 KKKKLFEILNDKKLFKPPV--LVFVD----CKLGADLLSEAVQKITGLKS-------------ISIHSEKSQIErknILK 489
Cdd:cd18802 8 KLQKLIEILREYFPKTPDFrgIIFVErratAVVLSRLLKEHPSTLAFIRCgfligrgnssqrkRSLMTQRKQKE---TLD 84
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1034562211 490 GLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGR 535
Cdd:cd18802 85 KFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR 130
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
220-541 |
1.07e-04 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 45.26 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 220 KSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKT-AAFLlpVIMRALFE-------SKTPSALILTPTRELAIQIERQA 291
Cdd:PRK13767 27 KEKFGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTlAAFL--AIIDELFRlgregelEDKVYCLYVSPLRALNNDIHRNL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 292 KELMSGLprmKTVLLVGGLPLPP----------QLYRLQQHVK----VIIATPgRLLDIIKQS---SVELCGVKIVVVDE 354
Cdd:PRK13767 105 EEPLTEI---REIAKERGEELPEirvairtgdtSSYEKQKMLKkpphILITTP-ESLAILLNSpkfREKLRTVKWVIVDE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 355 ----ADTmlKMGFQQQV-LDILENI-PNDCQTILVSATI-PtsIEQLASQLLHN-------PVRIITgeknlpcAN-VRQ 419
Cdd:PRK13767 181 ihslAEN--KRGVHLSLsLERLEELaGGEFVRIGLSATIeP--LEEVAKFLVGYeddgeprDCEIVD-------ARfVKP 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 420 IILWVEDPAK----------KKKLFEILndKKLFKP--PVLVFVDCKLGAD-----LLSEAVQKITGLKSISIHSEKSQI 482
Cdd:PRK13767 250 FDIKVISPVDdlihtpaeeiSEALYETL--HELIKEhrTTLIFTNTRSGAErvlynLRKRFPEEYDEDNIGAHHSSLSRE 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 483 ERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVG-RLGQ 541
Cdd:PRK13767 328 VRLEVEEKLKRGELKVVVSSTSLELGIDIGYIDLVVLLGSPKSVSRLLQRIGRAGhRLGE 387
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
480-538 |
1.51e-04 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 42.34 E-value: 1.51e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1034562211 480 SQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGR 538
Cdd:cd18801 75 SQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR 133
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
422-543 |
2.13e-04 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 41.85 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 422 LWVEDPAKKKKLFEIL-----NDKklfkppVLVFVDCKLGADLLSEAVQK--ITGlksisihsEKSQIERKNILKGLLEG 494
Cdd:cd18789 28 LAAMNPNKLRALEELLkrheqGDK------IIVFTDNVEALYRYAKRLLKpfITG--------ETPQSEREEILQNFREG 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1034562211 495 DYEVVVSTGVLGRGLDL--ISVRLVVNFdMPSSMDEYVHQIGRVGRLGQNG 543
Cdd:cd18789 94 EYNTLVVSKVGDEGIDLpeANVAIQISG-HGGSRRQEAQRLGRILRPKKGG 143
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
240-394 |
2.29e-04 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 42.66 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 240 GRDILASADTGSGKTAAFLLPVImrALFESKTPSALILT-PTRELAIQIERQAKELMSGLPRMKTVLLV----------- 307
Cdd:cd17930 1 PGLVILEAPTGSGKTEAALLWAL--KLAARGGKRRIIYAlPTRATINQMYERIREILGRLDDEDKVLLLhskaalelles 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 308 ----GGLPLPPQLYRLQQ----HVKVIIATPGRLLD-IIKQSSVE-----LCGvKIVVVDEA----DTMLKMgFQQQVLD 369
Cdd:cd17930 79 deepDDDPVEAVDWALLLkrswLAPIVVTTIDQLLEsLLKYKHFErrlhgLAN-SVVVLDEVqaydPEYMAL-LLKALLE 156
|
170 180
....*....|....*....|....*
gi 1034562211 370 ILENIpnDCQTILVSATIPTSIEQL 394
Cdd:cd17930 157 LLGEL--GGPVVLMTATLPALLRDE 179
|
|
| DEXDc_FANCM |
cd18033 |
DEAH-box helicase domain of FANCM; Fanconi anemia group M (FANCM) protein is a DNA-dependent ... |
249-355 |
3.81e-04 |
|
DEAH-box helicase domain of FANCM; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, it binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA), and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, it efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, it strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA. FANCM is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350791 [Multi-domain] Cd Length: 182 Bit Score: 41.92 E-value: 3.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 249 TGSGKTaaFLLPVIMRALFESkTPSALI--LTPTRELAIQiERQAKELMSGLPRMKTVLLVGGLPlPPQLYRLQQHVKVI 326
Cdd:cd18033 25 TGLGKT--FIAAVVMLNYYRW-FPKGKIvfMAPTKPLVSQ-QIEACYKITGIPSSQTAELTGSVP-PTKRAELWASKRVF 99
|
90 100
....*....|....*....|....*....
gi 1034562211 327 IATPGRLLDIIKQSSVELCGVKIVVVDEA 355
Cdd:cd18033 100 FLTPQTLENDLKEGDCDPKSIVCLVIDEA 128
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
222-408 |
4.47e-04 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 41.75 E-value: 4.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 222 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPvimrALFESKTpsALILTPTreLAIQierqaKELMSGLPRM 301
Cdd:cd17920 9 GYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLP----ALLLDGV--TLVVSPL--ISLM-----QDQVDRLQQL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 302 --KTVLLVGGLPLPPQLYRLQQH----VKVIIATPGRL-----LDIIkQSSVELCGVKIVVVDEADT-----------ML 359
Cdd:cd17920 76 giRAAALNSTLSPEEKREVLLRIkngqYKLLYVTPERLlspdfLELL-QRLPERKRLALIVVDEAHCvsqwghdfrpdYL 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1034562211 360 KMGfqqQVLDILENIPndcqTILVSAT-IPTSIEQLASQL-LHNPVRIITG 408
Cdd:cd17920 155 RLG---RLRRALPGVP----ILALTATaTPEVREDILKRLgLRNPVIFRAS 198
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
241-355 |
4.56e-04 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 41.87 E-value: 4.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 241 RDILASADTGSGKT-AAFLLPVIMRALFESKTPS---ALILTPTRELAIQierQAKELmsglpRMKTVLLVG------GL 310
Cdd:cd18034 17 RNTIVVLPTGSGKTlIAVMLIKEMGELNRKEKNPkkrAVFLVPTVPLVAQ---QAEAI-----RSHTDLKVGeysgemGV 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1034562211 311 PLPPQLYRLQ--QHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEA 355
Cdd:cd18034 89 DKWTKERWKEelEKYDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
229-355 |
4.57e-04 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 41.35 E-value: 4.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 229 IQMQMIPVGLLGRDILASADTGSGKTAAFLLpvIMRALFESKTPSALILTPTRELAIQIERQAKELMSglPRMKTVLLVG 308
Cdd:cd18035 5 LYQVLIAAVALNGNTLIVLPTGLGKTIIAIL--VAADRLTKKGGKVLILAPSRPLVEQHAENLKRVLN--IPDKITSLTG 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1034562211 309 GLPlPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEA 355
Cdd:cd18035 81 EVK-PEERAERWDASKIIVATPQVIENDLLAGRITLDDVSLLIFDEA 126
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
398-546 |
4.77e-04 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 40.70 E-value: 4.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 398 LLHNPVRIITGEKNLpcanvrqiilwVEDPAKKKKLFEILNDKKLfkpPVLVFVDCKLGADLLSEAVQKI---TGLKSIS 474
Cdd:cd18797 3 VLWNPPLLDRKDGER-----------GSARREAARLFADLVRAGV---KTIVFCRSRKLAELLLRYLKARlveEGPLASK 68
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034562211 475 IHSEKS---QIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRLGQNGTAI 546
Cdd:cd18797 69 VASYRAgylAEDRREIEAELFNGELLGVVATNALELGIDIGGLDAVVLAGYPGSLASLWQQAGRAGRRGKDSLVI 143
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
228-408 |
8.69e-04 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 41.09 E-value: 8.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 228 PIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVImraLFESKTPS-ALILTPTRELaiqIERQakelMSGLPR-MKTVL 305
Cdd:cd18018 15 PGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPAL---LLRRRGPGlTLVVSPLIAL---MKDQ----VDALPRaIKAAA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 306 LVGGLPLPPQLYRLQQ----HVKVIIATPGRLLD-----IIKQSSvelcGVKIVVVDEADTMLKMGFQ-----QQVLDIL 371
Cdd:cd18018 85 LNSSLTREERRRILEKlragEVKILYVSPERLVNesfreLLRQTP----PISLLVVDEAHCISEWSHNfrpdyLRLCRVL 160
|
170 180 190
....*....|....*....|....*....|....*...
gi 1034562211 372 ENIPNDCQTILVSATIPTS-IEQLASQLLHNPVRIITG 408
Cdd:cd18018 161 RELLGAPPVLALTATATKRvVEDIASHLGIPESGVVRG 198
|
|
| zf-HIT_ZNHIT1_like |
cd21437 |
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar ... |
103-135 |
9.70e-04 |
|
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar proteins; The family includes ZNHIT1 and its yeast counterpart, the vacuolar protein sorting-associated protein 71 (Vps71p). ZNHIT1, also known as cyclin-G1-binding protein 1 (CGBP1), zinc finger protein subfamily 4A member 1 (ZNFN4A1), or p18 Hamlet, may have a role in inducing apoptosis through p53 signaling. It binds to Rev-erb beta and releases its inhibitory effect on the transcription of apolipoprotein C3 (APOC3) without affecting its DNA-binding activity. The yeast counterpart Vps71p, also referred to as SWR complex protein 6 (Swc6p), plays a role in the exchange of histone H2A for the H2A variant HZT1, a euchromatin-specific factor, leading to chromatin remodeling and transcriptional changes of targeted genes. It is indirectly involved in vacuolar protein sorting. Members of this family contain a zf-HIT domain characterized by a "treble-clef" fold through interleaved CCCC and CCHC zinc finger motifs, both of which bind a zinc ion.
Pssm-ID: 467791 Cd Length: 43 Bit Score: 37.21 E-value: 9.70e-04
10 20 30
....*....|....*....|....*....|...
gi 1034562211 103 PGEPICVVCGRYGEYICDKTDEDVCSLECKAKH 135
Cdd:cd21437 5 PPRKFCSVCGYWGKYTCVRCGARYCSLKCLETH 37
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
219-399 |
1.22e-03 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 40.39 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 219 KKSGYEvPTPIQMQMIPVGLLGRDILASADTGSGKTAaFLLpvIMRALFESKTPSALILTPTRELAIQIERQAKElMSGL 298
Cdd:cd17924 12 KKTGFP-PWGAQRTWAKRLLRGKSFAIIAPTGVGKTT-FGL--ATSLYLASKGKRSYLIFPTKSLVKQAYERLSK-YAEK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 299 PRMKTVLLV--GGLPLPPQ---LYRLQQ-HVKVIIATPGRL---LDIIKQSSVELcgvkiVVVDEADTMLKMGfqqQVLD 369
Cdd:cd17924 87 AGVEVKILVyhSRLKKKEKeelLEKIEKgDFDILVTTNQFLsknFDLLSNKKFDF-----VFVDDVDAVLKSS---KNID 158
|
170 180 190
....*....|....*....|....*....|.
gi 1034562211 370 ILENIPNDCQTILVSATI-PTSIEQLASQLL 399
Cdd:cd17924 159 RLLKLLGFGQLVVSSATGrPRGIRPLLFREL 189
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
240-308 |
1.54e-03 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 41.45 E-value: 1.54e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034562211 240 GRDILASADTGSGKTAAFLLPVIMRALFESKTpsALILTPTRELAIQI-ERQAKELMSGLPR-MKTVLLVG 308
Cdd:COG1199 33 GRHLLIEAGTGTGKTLAYLVPALLAARETGKK--VVISTATKALQEQLvEKDLPLLRKALGLpLRVALLKG 101
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
433-538 |
2.76e-03 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 38.78 E-value: 2.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 433 LFEILNDKKlfkppVLVFVDC-----KLGADLLSEAVQKITGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGR 507
Cdd:cd18796 32 IFLLERHKS-----TLVFTNTrsqaeRLAQRLRELCPDRVPPDFIALHHGSLSRELREEVEAALKRGDLKVVVATSSLEL 106
|
90 100 110
....*....|....*....|....*....|.
gi 1034562211 508 GLDLISVRLVVNFDMPSSMDEYVHQIGRVGR 538
Cdd:cd18796 107 GIDIGDVDLVIQIGSPKSVARLLQRLGRSGH 137
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|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
226-355 |
4.10e-03 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 38.95 E-value: 4.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 226 PTPIQMQMIPVGLLGRDILASADTGSGKTaaFLLPVIMRALFESKTPS----ALILTPTRELAIQIERQAKELMsGLPRM 301
Cdd:cd17927 3 PRNYQLELAQPALKGKNTIICLPTGSGKT--FVAVLICEHHLKKFPAGrkgkVVFLANKVPLVEQQKEVFRKHF-ERPGY 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1034562211 302 KTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQ-SSVELCGVKIVVVDEA 355
Cdd:cd17927 80 KVTGLSGDTSENVSVEQIVESSDVIIVTPQILVNDLKSgTIVSLSDFSLLVFDEC 134
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|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
405-549 |
4.48e-03 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 38.30 E-value: 4.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 405 IITGEKNLPCANVRQIILWVEDPAKKKKLFEILNDKklfkpPVLVFVDCKLGADLLSeavQKITGlksISI-HSEKSQIE 483
Cdd:cd18795 9 VLGFNGLGIKLRVDVMNKFDSDIIVLLKIETVSEGK-----PVLVFCSSRKECEKTA---KDLAG---IAFhHAGLTRED 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034562211 484 RKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVN----FDmPSSMDEY----VHQ-IGRVGRLGQN--GTAITFI 549
Cdd:cd18795 78 RELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKgtqrYD-GKGYRELspleYLQmIGRAGRPGFDtrGEAIIMT 153
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
249-355 |
5.10e-03 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 39.86 E-value: 5.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 249 TGSGKTAAFLLpVIMRAL--FESKtpsALILTPTRELAIQIERQAKELMSgLPRMKTVLLVGGLPlPPQLYRLQQHVKVI 326
Cdd:PRK13766 38 TGLGKTAIALL-VIAERLhkKGGK---VLILAPTKPLVEQHAEFFRKFLN-IPEEKIVVFTGEVS-PEKRAELWEKAKVI 111
|
90 100 110
....*....|....*....|....*....|....*...
gi 1034562211 327 IATP---------GRlldiIKQSSVELCgvkivVVDEA 355
Cdd:PRK13766 112 VATPqviendliaGR----ISLEDVSLL-----IFDEA 140
|
|
| DEXHc_RecG |
cd17992 |
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in ... |
248-354 |
6.48e-03 |
|
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. It is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350750 [Multi-domain] Cd Length: 225 Bit Score: 38.67 E-value: 6.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 248 DTGSGKTA-AFLlpvIMRALFESKTPSALiLTPTRELAIQIERQAKELMSGLPrMKTVLLVGGLPLPPQLYRLQQ----H 322
Cdd:cd17992 74 DVGSGKTVvAAL---AMLAAVENGYQVAL-MAPTEILAEQHYDSLKKLLEPLG-IRVALLTGSTKAKEKREILEKiasgE 148
|
90 100 110
....*....|....*....|....*....|..
gi 1034562211 323 VKVIIATPGrlldIIkQSSVELCGVKIVVVDE 354
Cdd:cd17992 149 IDIVIGTHA----LI-QEDVEFHNLGLVIIDE 175
|
|
| SF2_C_reverse_gyrase |
cd18798 |
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological ... |
422-539 |
8.10e-03 |
|
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350185 [Multi-domain] Cd Length: 174 Bit Score: 37.67 E-value: 8.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562211 422 LWVEDPAKKKKLFEILndkKLFKPPVLVFVDCKLGADLLSEAVQKitgLKSISIHSEKSQIERKNILKGLLEGDYEVVV- 500
Cdd:cd18798 5 VYIEDSDSLEKLLELV---KKLGDGGLIFVSIDYGKEYAEELKEF---LERHGIKAELALSSTEKNLEKFEEGEIDVLIg 78
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1034562211 501 ---STGVLGRGLDL-ISVRLVVNFDMPssMDEYVHQIGRVGRL 539
Cdd:cd18798 79 vasYYGVLVRGIDLpERIKYAIFYGVP--VTTYIQASGRTSRL 119
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