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Conserved domains on  [gi|1034554942|ref|XP_016855617|]
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tudor and KH domain-containing protein isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
 104-196 2.57e-56

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410483  Cd Length: 95  Bit Score: 177.87  E-value: 2.57e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942 104 SRSLQLDKLVNEMTQHYENSVPED--LTVHVGDIVAAPLPTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRAL 181
Cdd:cd20412     1 SRSLQLDKLVQEMTQYYESEENRHtlLTVQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRAL 80

                          90
                  ....*....|....*
gi 1034554942 182 RSDFLSLPFQAIECS 196
Cdd:cd20412    81 RSDFLSLPFQAIECS 95
 
Name Accession Description Interval E-value
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
 104-196 2.57e-56

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 177.87  E-value: 2.57e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942 104 SRSLQLDKLVNEMTQHYENSVPED--LTVHVGDIVAAPLPTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRAL 181
Cdd:cd20412     1 SRSLQLDKLVQEMTQYYESEENRHtlLTVQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRAL 80

                          90
                  ....*....|....*
gi 1034554942 182 RSDFLSLPFQAIECS 196
Cdd:cd20412    81 RSDFLSLPFQAIECS 95
TUDOR pfam00567
Tudor domain;
82-198 3.98e-37

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 129.40  E-value: 3.98e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  82 EYLEVYVSASEHPNHFWIQIVgSRSLQLDKLVNEMTQHYENSVPEDLTVHVGDIVAAPLPTNGSWYRARVLGTLENGNLD 161
Cdd:pfam00567   1 STIDVVVSHIESPSTFYIQPK-SDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVE 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1034554942 162 LYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLA 198
Cdd:pfam00567  80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLA 116
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 131-185 3.90e-06

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 43.42  E-value: 3.90e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034554942  131 HVGDIVAAPLpTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRALRSDF 185
Cdd:smart00333   4 KVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57
 
Name Accession Description Interval E-value
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
 104-196 2.57e-56

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 177.87  E-value: 2.57e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942 104 SRSLQLDKLVNEMTQHYENSVPED--LTVHVGDIVAAPLPTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRAL 181
Cdd:cd20412     1 SRSLQLDKLVQEMTQYYESEENRHtlLTVQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRAL 80

                          90
                  ....*....|....*
gi 1034554942 182 RSDFLSLPFQAIECS 196
Cdd:cd20412    81 RSDFLSLPFQAIECS 95
TUDOR pfam00567
Tudor domain;
82-198 3.98e-37

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 129.40  E-value: 3.98e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  82 EYLEVYVSASEHPNHFWIQIVgSRSLQLDKLVNEMTQHYENSVPEDLTVHVGDIVAAPLPTNGSWYRARVLGTLENGNLD 161
Cdd:pfam00567   1 STIDVVVSHIESPSTFYIQPK-SDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVE 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1034554942 162 LYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLA 198
Cdd:pfam00567  80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLA 116
Tudor_AKAP1 cd20407
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ...
 130-202 2.60e-20

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410478  Cd Length: 76  Bit Score: 83.41  E-value: 2.60e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034554942 130 VHVGDIVAAPlpTNGSWYRARVLGTLENGNL-DLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAP 202
Cdd:cd20407     5 IEVGVICAAP--VMNAWYRAQVVGVFEETDEvEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 84-215 5.30e-18

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 79.47  E-value: 5.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  84 LEVYVSASEHPNHFWIQIVGSRSLQLDKLVNEMTQH---YENSVPEdltVHVGDIVAAPLPTNGSWYRARVLGTLENgNL 160
Cdd:cd20426     1 IEAYATAVDSPEYFWCQFATEKIQCLAVKVQEAGEQvadRGNFIPS---IYVGDPCIVKYSEDNHWYRALVTKINDN-LV 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034554942 161 DLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAPSGDQWEEEALDEF 215
Cdd:cd20426    77 SVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYF 131
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 86-212 1.46e-16

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 75.10  E-value: 1.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  86 VYVSASEHPNHFWIQIVGSRSLQ-LDKLVNEMTQHYENSVPEDLTV-HVGDIVAAPLPTNGSWYRARVlgtlENGNLD-- 161
Cdd:cd20408     1 GTVTEFKNPGEFYIQIYTLEVLEsLVKLTSQLKKTYASVNNHKEYIpEVGEVCVAKYSEDQNWYRALV----QTVDVQqk 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034554942 162 ---LYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAPSGDQWEEEAL 212
Cdd:cd20408    77 kagVFYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 143-202 3.23e-14

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 67.46  E-value: 3.23e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942 143 NGSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAP 202
Cdd:cd20415    37 DGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
 87-197 4.76e-14

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 67.86  E-value: 4.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  87 YVSASEHPNHFWIQIVGS-RSLQLDKLVNEMTQHYENS-------VPEDLtVHVGDIVAAPLPTNGSWYRARVLGTLENG 158
Cdd:cd20419     1 FVEYIESPSQFYVRFYSKdTSEMLEDMMIEMRRCYSNEhvseryvMPEAF-IQPGQVCCVRIPEDVWWYRVIIHQVLNKQ 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034554942 159 NLDLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSL 197
Cdd:cd20419    80 EVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 132-181 1.55e-13

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 64.07  E-value: 1.55e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034554942 132 VGDIVAAPLPTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRAL 181
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 84-197 2.23e-13

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 65.97  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  84 LEVYVSASEHPNHFWIQIVgSRSLQLDKLVNEMTQHYENSvpEDLTVHVGDIVAAPLPTNGSWYRARVLGTLENGNLDLY 163
Cdd:cd20439    12 VDVKCSYVNSPGDFWCQLQ-TKSSELKSLMKQIQSYYLIH--NDPYKHGQIACVAKYSKDGKWYRAAVLKQVSAKEVDVI 88

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1034554942 164 FVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSL 197
Cdd:cd20439    89 FVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSL 122
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 93-202 7.24e-13

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 64.96  E-value: 7.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  93 HPNHFWIQIVG----------SRSLQLDKLVNEMTQHY---ENSVPEDlTVHVGDIVAAPLPTNgSWYRARVLGTLENG- 158
Cdd:cd20435     1 DATHYSARILEhrssdgevtkSMSSTYLKLSMKLNMYYsdpSNRILHG-KVKVGDLCAVEDENN-LYHRVKVLEITEKDd 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1034554942 159 -----NLDLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAP 202
Cdd:cd20435    79 ktkprEVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKP 127
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 83-217 1.03e-12

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 64.45  E-value: 1.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  83 YLEVYVSASEHPNHFWIQIvGSRSLQLDKLVNEMTQHYENSVPED---LTVHVGDIVAAPLPTNGsWYRARVLGTLENGn 159
Cdd:cd20422     1 FYDAQVEFVKDPSEFWIRL-GEHAVPFSKLMRSMTAFYSQASKLDgvvLKPQPGQLCCAKWKEDR-YYRAIVTAVKGKM- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034554942 160 LDLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAPSGDQWEEEALDEFDR 217
Cdd:cd20422    78 VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFKR 135
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 143-204 3.54e-11

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 58.65  E-value: 3.54e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034554942 143 NGSWYRARVLGTLEN-GNLDLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLAR-IAPSG 204
Cdd:cd20423    16 DGKWCRALIDNVYEPvEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNlIQPSG 79
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 87-215 5.80e-11

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 59.80  E-value: 5.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  87 YVSASEHPNHFWIQIVGSRSlQLDKLVNEMTQHYENSVPEDLTVHV---GDIVAAPLPTNGSWYRArVLGTLENGNLDLY 163
Cdd:cd20438    10 FVEYVLNPSNFWIRTDEYNN-EFQALMKNIADIYNLCGNDEELLKKpepGLLCCARYSKDRHYYRA-VITEVLDLKVSVY 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034554942 164 FVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAPSGDQWEEEALDEF 215
Cdd:cd20438    88 FLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTKNANDFF 139
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 110-205 3.74e-10

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 56.28  E-value: 3.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942 110 DKLVNEMTQHYENSV--PEDLTVHVGDIVAAPlPTNGSWYRARVLGTLENgNLDLYFVDFGDNGDCPLKDLRALRSDFLS 187
Cdd:cd20427     1 EQMEDEMKEFYSKSStaMCLRSPSVGQLVAVK-AEEDAWLRAQVIEVEED-KVKVYYVDHGFSEVVERSKLFKLNKQFYS 78

                          90
                  ....*....|....*...
gi 1034554942 188 LPFQAIECSLARIAPSGD 205
Cdd:cd20427    79 LPFQATKCKLAGLEPFSD 96
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 85-197 3.77e-10

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 56.70  E-value: 3.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  85 EVYVSASEHPNHFWIQIVG--SRSLQLDKLVNEMTQHYENSVPEDLtvHVGDIVAAPLPTNGSWYRARVLGTLENGNLDL 162
Cdd:cd20425     3 EVYVSHVNSPSDFYVQLAQdeDELSMISEKLNASKANDEEVECESL--QLGDLICAEYPEDGLWYRAVVKEKIPNNLVSV 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034554942 163 YFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSL 197
Cdd:cd20425    81 QFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 94-200 3.78e-10

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 56.29  E-value: 3.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  94 PNHFWIQIVGSRS--LQLDKLVNEMTQHY-ENSvpeDLTVHVGDIVAAPLPTNGSWYRARVLGTLENGNLDLYFVDFGDN 170
Cdd:cd20441     2 PSRFFIQLSEDEKviLQLAEELNETSEKSrENA---AVKLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNT 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034554942 171 GDCPLKDLRALRSDFLSLPFQAIECSLARI 200
Cdd:cd20441    79 AVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 85-198 7.30e-10

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 55.89  E-value: 7.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  85 EVYVSASEHPNHFWIQIVgSRSLQLDKLVNEMTQHYENSVPE--DLTVHVGDIVAAPlPTNGSWYRARVLGTLENGNLDL 162
Cdd:cd20437     6 KVKITAAVSPSKFYCQLL-SWEPELSKLTTQMTLHYESVSKElnPSCENFGLLCAAK-GKDGQWHRGFLQQLLPPSQVKV 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1034554942 163 YFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLA 198
Cdd:cd20437    84 WFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 94-198 7.57e-10

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 55.92  E-value: 7.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  94 PNHFWIQIVGSRSLQ--LDKLVNEMTQhYENSVPEDLTVH--VGDIVAAPLPTNGSWYRARVLGTLENGNLDLYfVDFGD 169
Cdd:cd20411     9 PDLFYALPKTGQVNVekLKALMTELAE-YCSKQSVPQQFRprIGDACCARFTGDKNWYRAVVLETSDSEVKVLY-ADYGN 86

                          90       100
                  ....*....|....*....|....*....
gi 1034554942 170 NGDCPLKDLRALRSDFLSLPFQAIECSLA 198
Cdd:cd20411    87 TETLPLSRILPITKSHLELPFQIIRCSLA 115
Tudor_TDRD7_rpt3 cd20429
third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 108-193 6.99e-09

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410500  Cd Length: 91  Bit Score: 52.49  E-value: 6.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942 108 QLDKLVNEMTQHYENSVPEDLTVHVGDIVAAPLPTNgsWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRALRSDFLS 187
Cdd:cd20429     8 KLEVLMEEMILYYNKTEERPVAIEKNKVYAAKIENN--WYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIEKFRQ 85


                  ....*.
gi 1034554942 188 LPFQAI 193
Cdd:cd20429    86 LPFQAI 91
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 93-219 2.74e-08

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 52.04  E-value: 2.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  93 HPNHFWIQIVGSRSLQLDKLVNEMTQHYENSVPEDLTVHVGDIVAAPLPTNGSWYRARVLgTLENGNLDLYFVDFGDNGD 172
Cdd:cd20436    10 HPKEVLVKFQGQYNSICELDYHILQNEIQNATKSKSSWGVGEFCLVEDTTSGEWYRGRVL-EKIDEKYEVFLIDRGEVLN 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1034554942 173 CPLKDLRALRSDFLSLPFQAIECSLARIAPSGDQWEEEALDEFDRLT 219
Cdd:cd20436    89 VHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTAVNYFSSLI 135
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 132-186 3.68e-08

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481 [Multi-domain]  Cd Length: 59  Bit Score: 49.26  E-value: 3.68e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034554942 132 VGDIVAAPLPTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRALRSDFL 186
Cdd:cd20410     5 VGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
 108-185 5.11e-08

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 49.61  E-value: 5.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942 108 QLDKLVNEMTQHYENS--VPEDLTVHVGDIVAAPLPTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRALRSDF 185
Cdd:cd20433     4 QLEKLMEKLRFEIASNppLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPPAF 83
Tudor_AtTudor1-like cd20443
Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor ...
 97-202 6.09e-08

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410514 [Multi-domain]  Cd Length: 117  Bit Score: 50.54  E-value: 6.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  97 FWIQIVGSRSL-----QLDKLVNEmtqhyENSVPED-LTVHVGDIVAAPLPTNGSWYRARVLGTLENGN------LDLYF 164
Cdd:cd20443     4 FYVQVVSDQRLssiqqQLEGLSLK-----DKANPPGgFNPKKGELVLAQFSADNSWNRAMVVNAPRQGTqspkdeYEVFY 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1034554942 165 VDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAP 202
Cdd:cd20443    79 IDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 85-197 6.61e-08

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 50.53  E-value: 6.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  85 EVYVSASEHPNHFWIQIvGSRSLQLDKL---VNEMTQ--HYENSVPEDLTV----HVGDivaaplptnGSWYRARVLGTL 155
Cdd:cd20440    13 EVYITHVYSPAKFYCQL-DRNTEILEALmekIAEISKlfNSQILDNCKTRLclakYFED---------GQWYRALAHPVE 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1034554942 156 ENGNLDLYFVDFGDNGDCPLKDLRAL---RSDFLSLPFQAIECSL 197
Cdd:cd20440    83 SSSHLSVYFVDYGNKQIVEKNEVLPIpdtAVDLLLTPMQAIKCCL 127
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 85-197 8.38e-08

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 50.20  E-value: 8.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  85 EVYVSASEHPNHFWIQIvgSRSLQ-LDKLVNEMTQHYENSVPEDLTVHVGDIVAAPLpTNGSWYRARVLGTLENgnLDLY 163
Cdd:cd20424    15 EVYITYVNDPWTFYCQL--ARNAGvLDQLASAISRLSSEIRKLELSVNPGTLCLAKY-SDQHWYRGIIITNKNS--TEVF 89

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1034554942 164 FVDFGDNGDCPLKDLRALRSD---FLSLPFQAIECSL 197
Cdd:cd20424    90 FVDYGNTEKVEKEDMLPIPSDayeLLLLPMQAIKCSL 126
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 143-224 4.86e-07

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 47.40  E-value: 4.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942 143 NGSWYRARVLGTLENGNLDLY--FVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAPSGDQWEEEaldefdRLTH 220
Cdd:cd20418    16 DGKWYRAKLLSILEFNPVKILvrHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLNDSETE------RIPY 89


                  ....
gi 1034554942 221 CADW 224
Cdd:cd20418    90 CPEW 93
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 78-197 3.61e-06

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 45.88  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  78 FHADEYLEVYVSASEHPNHFWIQIvGSRSLQLDKLVNEMTQHYENSVPEDlTVHVGDIVAAPLPTNGS---WYRARVLGT 154
Cdd:cd20421     7 LQVGVTETVVVTEVTDPHRIFCQL-RSLSQELKRLSESMHQYYEGRVGSG-YETRPEKLGSPCAARGSdgrWYRAVLQQV 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034554942 155 LENGNL-DLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSL 197
Cdd:cd20421    85 FSANRVvEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCAL 128
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 131-185 3.90e-06

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 43.42  E-value: 3.90e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034554942  131 HVGDIVAAPLpTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRALRSDF 185
Cdd:smart00333   4 KVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57
Tudor_TDRD12_rpt1 cd20434
first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 92-202 5.76e-06

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410505  Cd Length: 164  Bit Score: 45.88  E-value: 5.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  92 EHPNHFWIQIVGSRSLQLD------KLVNEMTQHYeNSVPEDL------TVHVGDIVAAPLPTNGSWYRARVLGTLENGN 159
Cdd:cd20434     7 EDPGCFWGRILKGSGDLVVnpeeyeNLQDEMNQFY-HKGYKDVeeikpsTLEEGQVCVVFCEELKCWCRAVVESLMSSAD 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1034554942 160 LDL---YFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAP 202
Cdd:cd20434    86 DYLaecFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYGIKP 131
Tudor_TDRD7_rpt2 cd20428
second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 144-211 5.97e-06

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410499  Cd Length: 140  Bit Score: 45.13  E-value: 5.97e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034554942 144 GSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRALRSDFL----SLPFQAIECSLARIAPSGDQWEEEA 211
Cdd:cd20428    64 GKWARVEITNVHSSRALDVHFLDTGTVASVKVSELREIPPPFLreliSIPPQALKCCLADLPLNIGMWTPDA 135
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 108-186 2.11e-05

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 42.44  E-value: 2.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942 108 QLDKLVNEMTQHYENSVPE-DLTVHVGDIVAAPLPTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRALRSDFL 186
Cdd:cd20409     3 QLAELQESLSAYCKVAPASsDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPSLL 82
Tudor_SF cd04508
Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally ...
 133-179 2.32e-05

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.


Pssm-ID: 410449 [Multi-domain]  Cd Length: 47  Bit Score: 41.03  E-value: 2.32e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1034554942 133 GDIVAAPLPTNGSWYRARVLGTLENGNLDLYFVDfGDNGDCPLKDLR 179
Cdd:cd04508     1 GDRVEAKWSDDGQWYPATVVAVNDDGKYTVLFDD-GNEEEVSEDDIR 46
Tudor_TDRD15_rpt7 cd20442
seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 143-230 9.11e-05

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410513  Cd Length: 160  Bit Score: 42.33  E-value: 9.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942 143 NGSWYRARVLGTL-ENGNLDLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLAriapsgdqWEEEALDEFDRLThc 221
Cdd:cd20442    63 NLKWYRAVVEHLYpETEKMLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLCRWN--------WPESSKELSFEIL-- 132


                  ....*....
gi 1034554942 222 adWKPLVAK 230
Cdd:cd20442   133 --WKSLAGK 139
Tudor_TDRD9 cd20431
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ...
 94-189 4.55e-04

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410502  Cd Length: 101  Bit Score: 38.91  E-value: 4.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034554942  94 PNHFWIQIVGSRSL----QLDKLVNEMTQHYENSVPedltvHVGDIVAAPL--PTNGSWYRARVLGTLENgNLDLYFVDF 167
Cdd:cd20431     6 VGHFWGYRIDENSSeilqQLTAEINQRQLVPLTTKP-----VPNLLCLAPFtdADMKKYYRAKILYVSGS-SAEVFFVDY 79

                          90       100
                  ....*....|....*....|..
gi 1034554942 168 GDNGDCPLKDLRALRSDFLSLP 189
Cdd:cd20431    80 GNTSQVPSSLLREIPETLLTLP 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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