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Conserved domains on  [gi|1034187177|ref|XP_016816950|]
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U4/U6 small nuclear ribonucleoprotein Prp4 isoform X3 [Pan troglodytes]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-276 7.32e-77

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 239.04  E-value: 7.32e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  13 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319   145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL--------LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF 172
Cdd:COG2319   217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 173 SPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV 252
Cdd:COG2319   297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                         250       260
                  ....*....|....*....|....
gi 1034187177 253 MGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319   376 TSVAFSPDGRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-276 7.32e-77

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 239.04  E-value: 7.32e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  13 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319   145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL--------LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF 172
Cdd:COG2319   217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 173 SPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV 252
Cdd:COG2319   297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                         250       260
                  ....*....|....*....|....
gi 1034187177 253 MGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319   376 TSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-276 1.75e-70

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 219.13  E-value: 1.75e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177   8 RSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVM 87
Cdd:cd00200    29 GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY--------LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  88 WHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 167
Cdd:cd00200   101 FSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEV 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 168 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIWTHPGWSPLKTLAG 247
Cdd:cd00200   181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSG 259

                         250       260
                  ....*....|....*....|....*....
gi 1034187177 248 HEGKVMGLDISSDGQLIATCSYDRTFKLW 276
Cdd:cd00200   260 HTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 153-192 3.03e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 3.03e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1034187177  153 TGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWD 192
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
154-192 2.40e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 2.40e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034187177 154 GRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWD 192
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 135-276 2.58e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.63  E-value: 2.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 135 SLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP-NGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNlVTGVK 213
Cdd:PLN00181  546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQ 624

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034187177 214 FEPIHGNFLLTGAYDNTAKIWT--HPGWsPLKTLAGHEGKVMGLDISSDGQLIATcSYDRTFKLW 276
Cdd:PLN00181  625 FPSESGRSLAFGSADHKVYYYDlrNPKL-PLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLW 687
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-276 7.32e-77

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 239.04  E-value: 7.32e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  13 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319   145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL--------LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF 172
Cdd:COG2319   217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 173 SPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV 252
Cdd:COG2319   297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                         250       260
                  ....*....|....*....|....
gi 1034187177 253 MGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319   376 TSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
13-276 8.39e-72

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 225.95  E-value: 8.39e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  13 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319   103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKT--------LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF 172
Cdd:COG2319   175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 173 SPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV 252
Cdd:COG2319   255 SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333

                         250       260
                  ....*....|....*....|....
gi 1034187177 253 MGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-276 1.75e-70

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 219.13  E-value: 1.75e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177   8 RSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVM 87
Cdd:cd00200    29 GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY--------LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  88 WHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 167
Cdd:cd00200   101 FSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEV 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 168 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIWTHPGWSPLKTLAG 247
Cdd:cd00200   181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSG 259

                         250       260
                  ....*....|....*....|....*....
gi 1034187177 248 HEGKVMGLDISSDGQLIATCSYDRTFKLW 276
Cdd:cd00200   260 HTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
13-276 2.02e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.77  E-value: 2.02e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  13 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319    61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRL--------LASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF 172
Cdd:COG2319   133 KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 173 SPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV 252
Cdd:COG2319   213 SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                         250       260
                  ....*....|....*....|....
gi 1034187177 253 MGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319   292 NSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-276 1.86e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.72  E-value: 1.86e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  22 LLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYD 101
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKL--------LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 102 RSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIAT 181
Cdd:cd00200    73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 182 GSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIhGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDG 261
Cdd:cd00200   153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                         250
                  ....*....|....*
gi 1034187177 262 QLIATCSYDRTFKLW 276
Cdd:cd00200   232 YLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
42-276 7.26e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.12  E-value: 7.26e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  42 STVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGH 121
Cdd:COG2319    40 ASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGH 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 122 SMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYT 201
Cdd:COG2319   120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034187177 202 IPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319   200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
45-276 8.38e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.94  E-value: 8.38e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  45 SLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMG 124
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 125 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPA 204
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034187177 205 HQNLVTGVKFEPiHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319   161 HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 COG2319
WD40 repeat [General function prediction only];
13-194 1.58e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.77  E-value: 1.58e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  13 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319   229 RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL--------LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF 172
Cdd:COG2319   301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380

                         170       180
                  ....*....|....*....|..
gi 1034187177 173 SPNGYHIATGSGDNTCKVWDLR 194
Cdd:COG2319   381 SPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-192 2.95e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.93  E-value: 2.95e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  12 CKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPS 91
Cdd:cd00200   117 IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF--------VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  92 GRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 171
Cdd:cd00200   189 GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLA 268

                         170       180
                  ....*....|....*....|.
gi 1034187177 172 FSPNGYHIATGSGDNTCKVWD 192
Cdd:cd00200   269 WSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
13-153 8.63e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 8.63e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  13 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319   271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKL--------LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 342

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034187177  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRT 153
Cdd:COG2319   343 KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-108 4.65e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 4.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  10 GLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWH 89
Cdd:cd00200   199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL--------LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                          90
                  ....*....|....*....
gi 1034187177  90 PSGRFLGTTCYDRSWRLWD 108
Cdd:cd00200   271 PDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 153-192 3.03e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 3.03e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1034187177  153 TGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWD 192
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
154-192 2.40e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 2.40e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034187177 154 GRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWD 192
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
239-276 1.43e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 1.43e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034187177 239 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 276
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 239-276 1.46e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 1.46e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1034187177  239 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 276
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 135-276 2.58e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.63  E-value: 2.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 135 SLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP-NGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNlVTGVK 213
Cdd:PLN00181  546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQ 624

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034187177 214 FEPIHGNFLLTGAYDNTAKIWT--HPGWsPLKTLAGHEGKVMGLDISSDGQLIATcSYDRTFKLW 276
Cdd:PLN00181  625 FPSESGRSLAFGSADHKVYYYDlrNPKL-PLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLW 687
PTZ00421 PTZ00421
coronin; Provisional
 15-124 4.32e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.58  E-value: 4.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  15 WSVPD--------CNLLHtLRGHNTNVGAIVFHPKStvsldpKDVnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARV 86
Cdd:PTZ00421  103 WGIPEegltqnisDPIVH-LQGHTKKVGIVSFHPSA------MNV-LASAGADMVVNVWDVERGKAVEVIKCHSDQITSL 174

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1034187177  87 MWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMG 124
Cdd:PTZ00421  175 EWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-66 1.67e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 1.67e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177   7 DRSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWS 66
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR--------LASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 69-108 2.14e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.14e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1034187177   69 SDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 108
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 195-234 2.68e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 2.68e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1034187177  195 QRRCVYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIW 234
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 77-206 3.04e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.88  E-value: 3.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  77 EGHTVRVARVMWHPSGRFlgTTCYDRSWRLWDLEAQ-------EEILHQEGHSMGVYDIAFH--QDGSLAgTGGLDAFGR 147
Cdd:PTZ00421   75 EGPIIDVAFNPFDPQKLF--TASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSFHpsAMNVLA-SAGADMVVN 151

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034187177 148 VWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQ 206
Cdd:PTZ00421  152 VWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
WD40 pfam00400
WD domain, G-beta repeat;
196-234 4.20e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 4.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034187177 196 RRCVYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIW 234
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 26-191 9.92e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 9.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  26 LRGHNTNVGAIVFHP-KSTVsldpkdvnLASCAADGSVKLWSL-DSDEPVADIE-------GHTVRVARVMWHPSGRF-L 95
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEI--------LASGSEDLTIRVWEIpHNDESVKEIKdpqcilkGHKKKISIIDWNPMNYYiM 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  96 GTTCYDRSWRLWDLEAQE---EILHQEGHSMGVYDIAfhqdGS-LAGTGgldafgrvwdlrTGRCIMFLEGHLKEIygin 171
Cdd:PTZ00420  142 CSSGFDSFVNIWDIENEKrafQINMPKKLSSLKWNIK----GNlLSGTC------------VGKHMHIIDPRKQEI---- 201

                         170       180
                  ....*....|....*....|
gi 1034187177 172 fsPNGYHIATGsGDNTCKVW 191
Cdd:PTZ00420  202 --ASSFHIHDG-GKNTKNIW 218
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 10-191 1.32e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.15  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  10 GLCKLWSVPDCNLLHTLRGHNTNVGAIVFHpkstvSLDPkdVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWH 89
Cdd:PLN00181  555 GVVQVWDVARSQLVTEMKEHEKRVWSIDYS-----SADP--TLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177  90 PSGRFLGTTCYDRSWRLWDLEAQE-EILHQEGHSMGVYDIAFhQDGSLAGTGGLDAFGRVWDLRTGRC------IMFLEG 162
Cdd:PLN00181  628 ESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMG 706

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1034187177 163 H--LKEIYGINFSpNGYhIATGSGDNTCKVW 191
Cdd:PLN00181  707 HtnVKNFVGLSVS-DGY-IATGSETNEVFVY 735
WD40 pfam00400
WD domain, G-beta repeat;
71-108 1.34e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.34e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034187177  71 EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 108
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 21-66 3.43e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 3.43e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1034187177   21 NLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWS 66
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKY--------LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
21-66 6.00e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 6.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034187177  21 NLLHTLRGHNTNVGAIVFHPKSTVsldpkdvnLASCAADGSVKLWS 66
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL--------LASGSDDGTVKVWD 39
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
159-208 1.20e-03

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 40.01  E-value: 1.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034187177 159 FLEGHLKEIYGINFSPNGYHIATGSgDNTCKVWDLR-QRRCVYTIPAHQNL 208
Cdd:COG5170   275 FFEEIVSSISDFKFSDNGRYILSRD-YLTVKIWDVNmAKNPIKTIPMHCDL 324
PTZ00420 PTZ00420
coronin; Provisional
 119-225 1.31e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034187177 119 EGHSMGVYDIAFHQDGS-LAGTGGLDAFGRVWDLRTG----------RCImfLEGHLKEIYGINFSPNGYHIATGSG-DN 186
Cdd:PTZ00420   71 KGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIPHNdesvkeikdpQCI--LKGHKKKISIIDWNPMNYYIMCSSGfDS 148

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034187177 187 TCKVWDLRQRRCVYTIPAHQNLvTGVKFEpIHGNfLLTG 225
Cdd:PTZ00420  149 FVNIWDIENEKRAFQINMPKKL-SSLKWN-IKGN-LLSG 184
WD40 pfam00400
WD domain, G-beta repeat;
119-150 2.14e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.14e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1034187177 119 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWD 150
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 177-234 5.29e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 37.74  E-value: 5.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034187177 177 YHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIW 234
Cdd:pfam20426  95 FLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTS-DGSILATGSYDTTVMVW 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 119-150 6.41e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 6.41e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034187177  119 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWD 150
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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