NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034174911|ref|XP_016810791|]
View 

zinc finger protein 76 isoform X3 [Pan troglodytes]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11779416)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  22803940|11361095|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-366 2.57e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 179 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--KPYKCPEELCSKAFKTSGDLQKHVRTHTGER 253
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 254 PFRCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFT- 327
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNr 430

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1034174911 328 EYSSlyKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRS 366
Cdd:COG5048   431 HYNL--IPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-220 5.62e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 5.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 106 SDSTILAVQTEVGLEDLAAED-DEGFSADTVVALEQYAS-------KVLHDSQ--IPHNGKGQQV-GDRAFRCGYKGCGR 174
Cdd:COG5189   280 FEESSLGFDYEFIHKSVGNKEiRGGISTGEMIDVRKLPCtnsssngKLAHGGErnIDTPSRMLKVkDGKPYKCPVEGCNK 359

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034174911 175 LYTTAHHLKVH---------------ERAHTG----DRPYRCDFpsCGKAFATGYGLKSHvRTHT 220
Cdd:COG5189   360 KYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-366 2.57e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 179 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--KPYKCPEELCSKAFKTSGDLQKHVRTHTGER 253
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 254 PFRCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFT- 327
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNr 430

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1034174911 328 EYSSlyKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRS 366
Cdd:COG5048   431 HYNL--IPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-238 3.62e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 3.62e-06
                          10        20
                  ....*....|....*....|....*..
gi 1034174911 212 LKSHVRTHTGEKPYKCPEelCSKAFKT 238
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-220 5.62e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 5.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 106 SDSTILAVQTEVGLEDLAAED-DEGFSADTVVALEQYAS-------KVLHDSQ--IPHNGKGQQV-GDRAFRCGYKGCGR 174
Cdd:COG5189   280 FEESSLGFDYEFIHKSVGNKEiRGGISTGEMIDVRKLPCtnsssngKLAHGGErnIDTPSRMLKVkDGKPYKCPVEGCNK 359

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034174911 175 LYTTAHHLKVH---------------ERAHTG----DRPYRCDFpsCGKAFATGYGLKSHvRTHT 220
Cdd:COG5189   360 KYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
PHA00733 PHA00733
hypothetical protein
 314-363 5.99e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 5.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034174911 314 PYVCtvPGCGKRFTEYSSLYKHHVVHTHCKpyTCSTCGKTYRQTSTLAMH 363
Cdd:PHA00733   73 PYVC--PLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-366 2.57e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 179 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--KPYKCPEELCSKAFKTSGDLQKHVRTHTGER 253
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 254 PFRCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFT- 327
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNr 430

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1034174911 328 EYSSlyKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRS 366
Cdd:COG5048   431 HYNL--IPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-336 2.64e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911  94 STAYIHHPVAVPSDSTILAVQTEVGLEDLAAEDDEGFSADTVVALEQYASKVLHDSQiPHNGKGQQvgdraFRCgyKGCG 173
Cdd:COG5048   225 SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSS-SEKGFSLP-----IKS--KQCN 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 174 RLYTTAHHLKVHERA--HTG--DRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAF------KTSGDLQ 243
Cdd:COG5048   297 ISFSRSSPLTRHLRSvnHSGesLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnnEPPQSLQ 376

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 244 KHVRTHTgERPFRCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCtvpgCG 323
Cdd:COG5048   377 QYKDLKN-DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC----SI 451

                         250
                  ....*....|...
gi 1034174911 324 KRFTEYSSLYKHH 336
Cdd:COG5048   452 LKSFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 311-368 3.09e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 55.88  E-value: 3.09e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034174911 311 GEKPYVCTVPGCGKRFTEYSSLyKHHVVHTHC--------------------KPYTCSTCGKTYRQTSTLAMHKRSAH 368
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGL-KYHMLHGHQnqklhenpspekmnifsakdKPYRCEVCDKRYKNLNGLKYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-340 1.20e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034174911 283 RPYTCPEphCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHT 340
Cdd:COG5048    32 RPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-257 2.37e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.37e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034174911 192 DRPYRCDFpsCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFRC 257
Cdd:COG5048    31 PRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-238 3.62e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 3.62e-06
                          10        20
                  ....*....|....*....|....*..
gi 1034174911 212 LKSHVRTHTGEKPYKCPEelCSKAFKT 238
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 191-280 3.98e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.33  E-value: 3.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 191 GDRPYRCDFPSCGKAFATGYGLKSH-VRTHTGEKPYKCPEELCSKAFKTSgdlqkhvrthtgERPFRCPFegCGRSFTTS 269
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAK------------DKPYRCEV--CDKRYKNL 411

                          90
                  ....*....|.
gi 1034174911 270 NIRKVHvRTHT 280
Cdd:COG5189   412 NGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-268 3.25e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.25e-05
                          10        20
                  ....*....|....*....|....*...
gi 1034174911 241 DLQKHVRTHTGERPFRCPFegCGRSFTT 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-220 5.62e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 5.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 106 SDSTILAVQTEVGLEDLAAED-DEGFSADTVVALEQYAS-------KVLHDSQ--IPHNGKGQQV-GDRAFRCGYKGCGR 174
Cdd:COG5189   280 FEESSLGFDYEFIHKSVGNKEiRGGISTGEMIDVRKLPCtnsssngKLAHGGErnIDTPSRMLKVkDGKPYKCPVEGCNK 359

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034174911 175 LYTTAHHLKVH---------------ERAHTG----DRPYRCDFpsCGKAFATGYGLKSHvRTHT 220
Cdd:COG5189   360 KYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-327 3.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.07e-04
                          10        20
                  ....*....|....*....|....*..
gi 1034174911 301 NYKNHVRIHTGEKPYVCTVpgCGKRFT 327
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-275 3.56e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 147 HDSQIPHNGKGQqvgdRAFRCGYKGCGRLYTTAHHLKVHERAHTG----------------------------------- 191
Cdd:COG5048   308 HLRSVNHSGESL----KPFSCPYSLCGKLFSRNDALKRHILLHTSispakekllnssskfspllnneppqslqqykdlkn 383

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 192 DRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFRCpfEGCGRSFTTSNI 271
Cdd:COG5048   384 DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDL 461


                  ....
gi 1034174911 272 RKVH 275
Cdd:COG5048   462 SNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
181-208 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....*...
gi 1034174911 181 HLKVHERAHTGDRPYRCdfPSCGKAFAT 208
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-375 1.53e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034174911 223 KPYKCPEelCSKAFKTSGDLQKHVRTHTGERPFRCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCpephcgrgftSATNY 302
Cdd:COG5048    32 RPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLN----------SKSLP 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034174911 303 KNHVrihtgeKPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRSAHGELEATE 375
Cdd:COG5048   100 LSNS------KASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNS 166
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-298 2.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034174911 273 KVHVRTHTGERPYTCPEphCGRGFTS 298
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPE--CGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 314-363 5.99e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 5.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034174911 314 PYVCtvPGCGKRFTEYSSLYKHHVVHTHCKpyTCSTCGKTYRQTSTLAMH 363
Cdd:PHA00733   73 PYVC--PLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH