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Conserved domains on  [gi|1012274348|ref|XP_015984885|]
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mediator of RNA polymerase II transcription subunit 23 isoform X1 [Rousettus aegyptiacus]

Protein Classification

Med23 domain-containing protein( domain architecture ID 10569018)

Med23 domain-containing protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 4-1316 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


:

Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2206.79  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348    4 METQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLY 83
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348   84 DCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQL 163
Cdd:pfam11573   81 QLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  164 LAAREVIAYILERNACLLPAYFAVTEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---A 239
Cdd:pfam11573  161 RALENVILYILDRNACLLPAYFIVNEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  240 ICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQtlniaqHKQRCPVLEDQLVDLVVY 319
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQ------HKQRCKALEEQLVELMIC 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  320 AMERSETEEkfDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALA 399
Cdd:pfam11573  315 AMERSETEP--EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLS 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  400 DFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQ-SLRNKS--L 476
Cdd:pfam11573  393 DFLPILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnL 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  477 QMN-DYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMrvplPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATR 555
Cdd:pfam11573  473 AMGsDYRIALLCNAYSTNTEYFSRPMPALVETILGNSKS----RSPGCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTH 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  556 VIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSH 635
Cdd:pfam11573  549 VIKFAQSKSSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSH 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  636 LHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVTdfftGSD 714
Cdd:pfam11573  629 LHSLANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----GTG 704

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  715 SIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFQQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGS 794
Cdd:pfam11573  705 TDSESWCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGT 784

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  795 PPLFLCLLWKMLLDTDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRL 874
Cdd:pfam11573  785 PPLFLCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRL 864

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  875 ILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPpv 954
Cdd:pfam11573  865 VLCLALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS-- 942

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  955 qiQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRERAYLKRK 1034
Cdd:pfam11573  943 --SNPYLPTYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRK 1020

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348 1035 LVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREDNPWVPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHAL 1114
Cdd:pfam11573 1021 LVSAIIGSLKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHAL 1100

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348 1115 HVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDQIVSVISSPSLTSETEWvG 1194
Cdd:pfam11573 1101 YVTCVELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-C 1179

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348 1195 YPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTR 1274
Cdd:pfam11573 1180 SPFELFNFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERER 1259

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|..
gi 1012274348 1275 CMIEIGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTG 1316
Cdd:pfam11573 1260 GVLDITKLLYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 4-1316 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2206.79  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348    4 METQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLY 83
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348   84 DCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQL 163
Cdd:pfam11573   81 QLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  164 LAAREVIAYILERNACLLPAYFAVTEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---A 239
Cdd:pfam11573  161 RALENVILYILDRNACLLPAYFIVNEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  240 ICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQtlniaqHKQRCPVLEDQLVDLVVY 319
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQ------HKQRCKALEEQLVELMIC 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  320 AMERSETEEkfDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALA 399
Cdd:pfam11573  315 AMERSETEP--EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLS 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  400 DFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQ-SLRNKS--L 476
Cdd:pfam11573  393 DFLPILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnL 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  477 QMN-DYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMrvplPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATR 555
Cdd:pfam11573  473 AMGsDYRIALLCNAYSTNTEYFSRPMPALVETILGNSKS----RSPGCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTH 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  556 VIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSH 635
Cdd:pfam11573  549 VIKFAQSKSSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSH 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  636 LHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVTdfftGSD 714
Cdd:pfam11573  629 LHSLANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----GTG 704

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  715 SIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFQQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGS 794
Cdd:pfam11573  705 TDSESWCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGT 784

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  795 PPLFLCLLWKMLLDTDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRL 874
Cdd:pfam11573  785 PPLFLCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRL 864

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  875 ILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPpv 954
Cdd:pfam11573  865 VLCLALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS-- 942

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  955 qiQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRERAYLKRK 1034
Cdd:pfam11573  943 --SNPYLPTYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRK 1020

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348 1035 LVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREDNPWVPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHAL 1114
Cdd:pfam11573 1021 LVSAIIGSLKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHAL 1100

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348 1115 HVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDQIVSVISSPSLTSETEWvG 1194
Cdd:pfam11573 1101 YVTCVELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-C 1179

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348 1195 YPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTR 1274
Cdd:pfam11573 1180 SPFELFNFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERER 1259

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|..
gi 1012274348 1275 CMIEIGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTG 1316
Cdd:pfam11573 1260 GVLDITKLLYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 4-1316 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2206.79  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348    4 METQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLY 83
Cdd:pfam11573    1 EVNQVKSIINEILKVEIIEEAFSGFTSNLPDDEKEKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRLDFLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348   84 DCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQL 163
Cdd:pfam11573   81 QLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEKVPQL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  164 LAAREVIAYILERNACLLPAYFAVTEIRKLYPEGK-LPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSG---A 239
Cdd:pfam11573  161 RALENVILYILDRNACLLPAYFIVNEIMKGYPDAKmWPHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHSGyadH 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  240 ICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQtlniaqHKQRCPVLEDQLVDLVVY 319
Cdd:pfam11573  241 LTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQ------HKQRCKALEEQLVELMIC 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  320 AMERSETEEkfDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALA 399
Cdd:pfam11573  315 AMERSETEP--EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKNPLS 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  400 DFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQ-SLRNKS--L 476
Cdd:pfam11573  393 DFLPILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHlVLNNDSpnL 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  477 QMN-DYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMrvplPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATR 555
Cdd:pfam11573  473 AMGsDYRIALLCNAYSTNTEYFSRPMPALVETILGNSKS----RSPGCNAPGPTTPLSMEFLDSLTVHSKMSLIHSIVTH 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  556 VIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSH 635
Cdd:pfam11573  549 VIKFAQSKSSVALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPHYRVQLLSH 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  636 LHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVL-SAESEELNRALILTLARATHVTdfftGSD 714
Cdd:pfam11573  629 LHSLANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTFLvSQESEELNRALILTLARAIHIT----GTG 704

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  715 SIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFQQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGS 794
Cdd:pfam11573  705 TDSESWCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDIIAHFSVPGT 784

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  795 PPLFLCLLWKMLLDTDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRL 874
Cdd:pfam11573  785 PPLFLCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMIWKYNIVTIDRL 864

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  875 ILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPpv 954
Cdd:pfam11573  865 VLCLALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAPEGVAEYDSS-- 942

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348  955 qiQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRERAYLKRK 1034
Cdd:pfam11573  943 --SNPYLPTYFGNVCLRFLPVLDIVIHRALELPPVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPDLKRK 1020

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348 1035 LVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREDNPWVPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHAL 1114
Cdd:pfam11573 1021 LVSAIIGSLKDCRPPGWALTEAYEKYHQKSSDEQLIWLPEDYYMKLIDRMVDTMDGKTPPPFPAKDWRFNEFPNPGAHAL 1100

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348 1115 HVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDQIVSVISSPSLTSETEWvG 1194
Cdd:pfam11573 1101 YVTCVELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPELTNWTYP-C 1179

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012274348 1195 YPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTR 1274
Cdd:pfam11573 1180 SPFELFNFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQRFRAERER 1259

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|..
gi 1012274348 1275 CMIEIGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTG 1316
Cdd:pfam11573 1260 GVLDITKLLYELLEQVDKEGVELRYMDPICDLLYHIKYMFVG 1301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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