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Conserved domains on  [gi|1002293392|ref|XP_015651037|]
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grpE protein homolog 2, mitochondrial isoform X2 [Oryza sativa Japonica Group]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 144-293 1.08e-55

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


:

Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 176.93  E-value: 1.08e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 144 KDMKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRASSVVKESfskidtsnesaeavKLLNTLLEG 223
Cdd:cd00446     1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKE--------------EELKNLLEG 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 224 VEMTEKQLGEVFKKFGVEKFDPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:cd00446    67 VEMTLKQLLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 144-293 1.08e-55

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 176.93  E-value: 1.08e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 144 KDMKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRASSVVKESfskidtsnesaeavKLLNTLLEG 223
Cdd:cd00446     1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKE--------------EELKNLLEG 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 224 VEMTEKQLGEVFKKFGVEKFDPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:cd00446    67 VEMTLKQLLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 137-293 1.46e-53

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 171.87  E-value: 1.46e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 137 KSKDEEVKDMKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRASsvvkesfskidtsnESAEAVKL 216
Cdd:COG0576     2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERAL--------------AAAEEDED 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002293392 217 LNTLLEGVEMTEKQLGEVFKKFGVEKFDPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:COG0576    68 VKSLLEGVEMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVV 144
GrpE pfam01025
GrpE;
123-293 4.03e-52

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 168.94  E-value: 4.03e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 123 EDLTKLVLEKEELLKSKDEEVKDMKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRAssvvkesfs 202
Cdd:pfam01025   7 EALTDEIESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERA--------- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 203 kIDTSNESAEavklLNTLLEGVEMTEKQLGEVFKKFGVEKFDPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLH 282
Cdd:pfam01025  78 -LNSAPENED----VKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLH 152

                         170
                  ....*....|.
gi 1002293392 283 DRVLRPAEVGV 293
Cdd:pfam01025 153 DRVLRPAMVVV 163
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 87-293 7.08e-51

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 167.15  E-value: 7.08e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  87 DGVNKSTQSEASNETNSSPGTENAsqADTEDLDLSKEDLTklvlekeELLKskdEEVKDMKDKVLRSYAEMENVIARTKR 166
Cdd:PRK14141    3 DEKNKNGNPADAARDANNPVDREA--KPYEMEDDPEPDPL-------EALK---AENAELKDRMLRLAAEMENLRKRTQR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 167 ESDNAKKYAVQGFSKSLLDVADNLSRASSVVKESfskidtSNESAEAVklLNTLLEGVEMTEKQLGEVFKKFGVEKFDPL 246
Cdd:PRK14141   71 DVADARAYGIAGFARDMLSVSDNLRRALDAIPAE------ARAAADAG--LKALIEGVEMTERAMLNALERHGVKKLDPE 142

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1002293392 247 NEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14141  143 GQKFDPNFHQAMFEVPNPDVPNNTVVQVVQAGYTIGERVLRPAMVGV 189
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 81-253 3.72e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 39.26  E-value: 3.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392   81 ANKQTEDGVNKSTQSEASNETNSSPGTENASQADT-EDLDLSKEDLTKLVLEKEELLKSKDEeVKDMKDKVLRSYAEMEN 159
Cdd:TIGR01612  775 AKEKDELNKYKSKISEIKNHYNDQINIDNIKDEDAkQNYDKSKEYIKTISIKEDEIFKIINE-MKFMKDDFLNKVDKFIN 853

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  160 VIARTKRESDNAKKYAVQGFSKSLLDVADN-LSRASSVVKESFSKIDTSNESAEA-VKLLNTL--LEGVEMTEKQLGEVF 235
Cdd:TIGR01612  854 FENNCKEKIDSEHEQFAELTNKIKAEISDDkLNDYEKKFNDSKSLINEINKSIEEeYQNINTLkkVDEYIKICENTKESI 933

                          170
                   ....*....|....*...
gi 1002293392  236 KKFGvEKFDPLNEKFDPN 253
Cdd:TIGR01612  934 EKFH-NKQNILKEILNKN 950
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 144-293 1.08e-55

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 176.93  E-value: 1.08e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 144 KDMKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRASSVVKESfskidtsnesaeavKLLNTLLEG 223
Cdd:cd00446     1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKE--------------EELKNLLEG 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 224 VEMTEKQLGEVFKKFGVEKFDPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:cd00446    67 VEMTLKQLLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 137-293 1.46e-53

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 171.87  E-value: 1.46e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 137 KSKDEEVKDMKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRASsvvkesfskidtsnESAEAVKL 216
Cdd:COG0576     2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERAL--------------AAAEEDED 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002293392 217 LNTLLEGVEMTEKQLGEVFKKFGVEKFDPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:COG0576    68 VKSLLEGVEMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVV 144
GrpE pfam01025
GrpE;
123-293 4.03e-52

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 168.94  E-value: 4.03e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 123 EDLTKLVLEKEELLKSKDEEVKDMKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRAssvvkesfs 202
Cdd:pfam01025   7 EALTDEIESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERA--------- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 203 kIDTSNESAEavklLNTLLEGVEMTEKQLGEVFKKFGVEKFDPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLH 282
Cdd:pfam01025  78 -LNSAPENED----VKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLH 152

                         170
                  ....*....|.
gi 1002293392 283 DRVLRPAEVGV 293
Cdd:pfam01025 153 DRVLRPAMVVV 163
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 87-293 7.08e-51

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 167.15  E-value: 7.08e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  87 DGVNKSTQSEASNETNSSPGTENAsqADTEDLDLSKEDLTklvlekeELLKskdEEVKDMKDKVLRSYAEMENVIARTKR 166
Cdd:PRK14141    3 DEKNKNGNPADAARDANNPVDREA--KPYEMEDDPEPDPL-------EALK---AENAELKDRMLRLAAEMENLRKRTQR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 167 ESDNAKKYAVQGFSKSLLDVADNLSRASSVVKESfskidtSNESAEAVklLNTLLEGVEMTEKQLGEVFKKFGVEKFDPL 246
Cdd:PRK14141   71 DVADARAYGIAGFARDMLSVSDNLRRALDAIPAE------ARAAADAG--LKALIEGVEMTERAMLNALERHGVKKLDPE 142

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1002293392 247 NEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14141  143 GQKFDPNFHQAMFEVPNPDVPNNTVVQVVQAGYTIGERVLRPAMVGV 189
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 82-293 2.36e-37

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 131.66  E-value: 2.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  82 NKQTEDGVNKSTQSEASNETNSSPGTENASQADTEDldlskedltklvlEKEELLKSKDEEVKDMKDKVLRSYAEMENVI 161
Cdd:PRK14140    5 NEQVEEEVEETEVEEAVEDEVEEETVEEESEAELLD-------------EEQAKIAELEAKLDELEERYLRLQADFENYK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 162 ARTKRESDNAKKYAVQGFSKSLLDVADNLSRASsvvkesfsKIDTSNESAEAvkllntLLEGVEMTEKQLGEVFKKFGVE 241
Cdd:PRK14140   72 RRIQKENEAAEKYRAQSLASDLLPALDNFERAL--------QIEADDEQTKS------LLKGVEMVHRQLLEALKKEGVE 137

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1002293392 242 KFDPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14140  138 VIEAVGEQFDPNLHQAVMQDEDEDFESNEVVEELQKGYKLKDRVIRPSMVKV 189
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 90-293 2.25e-35

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 126.57  E-value: 2.25e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  90 NKSTQSEASNETNSSPGTENASQADTEDLDLSKEDLTklVLEKEELLKSKDEEVKDMkdkVLRSYAEMENVIARTKRESD 169
Cdd:PRK14150    6 QKTPQEQVSEEIEAEVEQQEEADEAELEDELDEADAR--IAELEAQLAEAQAEERDS---VLRARAEVENIRRRAEQDVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 170 NAKKYAVQGFSKSLLDVADNLSRAssvvkesfskIDTSNESAEAVKllnTLLEGVEMTEKQLGEVFKKFGVEKFDPLNEK 249
Cdd:PRK14150   81 KAHKFALEKFANELLPVIDNLERA----------LQAADKENEALK---ALIEGVELTLKSLLDTVAKFGVEVVGPVGEP 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1002293392 250 FDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14150  148 FNPEVHQAISMQESEDHEPNTVMMVMQKGYTLNGRLLRPAMVMV 191
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 112-293 3.36e-33

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 121.23  E-value: 3.36e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 112 QADTEDLDLSKEDLtklvLEKEELLKSkdeEVKDMKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLS 191
Cdd:PRK14155    5 QTPAEDGPFEADDA----AQEIEALKA---EVAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 192 RASSVvkesfSKIDTSNesaEAVKllnTLLEGVEMTEKQLGEVFKKFGVEKFDP-LNEKFDPNKHAALFQIPDPSKPSGT 270
Cdd:PRK14155   78 RATAA-----SPKDSAD---PAVK---NFIIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQPSTEVAAGG 146

                         170       180
                  ....*....|....*....|...
gi 1002293392 271 VAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14155  147 VLQVMQAGYELMGRLVRPAMVAV 169
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 95-294 3.73e-33

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 120.46  E-value: 3.73e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  95 SEASNETNSSPGTENASQADTEDLDlSKEDLTKLVLEKEELLKSKDEEVKDMKDKVLRSYAEMENVIARTKRESDNAKKY 174
Cdd:PRK14139    1 MENTQQNPSEQEAEEAGAAAQAAAA-AAAAAEDAAPALEAELAEAEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 175 AVQGFSKSLLDVADNLSRAssvvkesfskIDTSNESAEAVKllntllEGVEMTEKQLGEVFKKFGVEKFDPLNEKFDPNK 254
Cdd:PRK14139   80 AIESFAESLLPVKDSLEAA----------LADESGDLEKLR------EGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQ 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1002293392 255 HAALFQIPDPSKPSgTVAAVVKVGYMLHDRVLRPAEVGVT 294
Cdd:PRK14139  144 HQAISMVPAEQEPN-TVVAVLQKGYTIADRVLRPALVTVA 182
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 93-291 1.24e-27

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 106.38  E-value: 1.24e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  93 TQSEASNETNSSPGTENASQADTEDLDLSKEdLTKLVLEKE-----ELLKSKDEEVKDMKDKVLRSYAEMENVIARTKRE 167
Cdd:PRK14148    2 SKQEKSNVEDKSLDIETAAQVETAQESASGA-LEELSVEEQlerakDTIKELEDSCDQFKDEALRAKAEMENIRKRAERD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 168 SDNAKKYAVQGFSKSLLDVADNLSRASsvvkesfsKIDTSNESAEAVKllntllEGVEMTEKQLGEVFKKFGVEKFDPLN 247
Cdd:PRK14148   81 VSNARKFGIEKFAKELLPVIDSIEQAL--------KHEVKLEEAIAMK------EGIELTAKMLVDILKKNGVEELDPKG 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1002293392 248 EKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEV 291
Cdd:PRK14148  147 EKFDPNLHEAMAMIPNPEFEDNTIFDVFQKGYMLNGRIVRAAKV 190
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 97-294 7.97e-27

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 103.70  E-value: 7.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  97 ASNETNSSPGTENASQADTEdldlSKEDLTKLVLEKEELLKSKdeevkdmKDKVLRSYAEMENVIARTKRESDNAKKYAV 176
Cdd:PRK14151    1 MADEQTLDLQAPEAAQAEAA----AGDDLTARVQELEEQLAAA-------KDQSLRAAADLQNVRRRAEQDVEKAHKFAL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 177 QGFSKSLLDVADNLSRAssvvkesfskIDTSNESAEAVKllnTLLEGVEMTEKQLGEVFKKFGVEKFDPLNEKFDPNKHA 256
Cdd:PRK14151   70 EKFAGDLLPVVDSLERG----------LELSSADDEAIK---PMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQ 136

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1002293392 257 ALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGVT 294
Cdd:PRK14151  137 AMAMQESADVEPNSVLKVFQKGYLLNGRLLRPAMVVVS 174
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 108-294 6.51e-26

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 101.20  E-value: 6.51e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 108 ENASQADTEDLDLSKEdltKLVLEKEELLKSKdEEVKDMKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVA 187
Cdd:PRK14161    4 DNIENNEQTINDIAEE---IVETANPEITALK-AEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 188 DNLSRASSvVKESFSKIDTSNesaeavkllntLLEGVEMTEKQLGEVFKKFGVEKFDP-LNEKFDPNKHAALFQIPDPSK 266
Cdd:PRK14161   80 DNLSRALA-HKPANSDVEVTN-----------IIAGVQMTKDELDKVFHKHHIEEIKPeIGSMFDYNLHNAISQIEHPDH 147

                         170       180
                  ....*....|....*....|....*...
gi 1002293392 267 PSGTVAAVVKVGYMLHDRVLRPAEVGVT 294
Cdd:PRK14161  148 APNSIITLMQSGYKIRDRLLRPATVQVV 175
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 91-293 9.39e-25

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 98.76  E-value: 9.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  91 KSTQSEASNETNSSPGTENASQADTEDLDLSKEdltklvLEKEELlkskDEEVKDMKDKVLRSYAEMENVIARTKRESDN 170
Cdd:PRK14153    7 GKDKAENSEARNSGSSAEEAEELKEEPEDSTAD------SETEKC----REEIESLKEQLFRLAAEFDNFRKRTAREMEE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 171 AKKYAVQGFSKSLLDVADNLSRASsvvkesfskidtsnESAEAVKLLNTLLEGVEMTEKQLGEVFKKFGVEKFDPLNEKF 250
Cdd:PRK14153   77 NRKFVLEQVLLDLLEVTDNFERAL--------------ESARTAEDMNSIVEGIEMVSKQFFSILEKYGLERIECEGEEF 142

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1002293392 251 DPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14153  143 DPHRHEAMMHVETSEVPDNTIVDVCKPGYALNSKVIRPAMVSV 185
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 75-294 1.26e-24

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 98.64  E-value: 1.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  75 QQDDKAANKQTEDGVNKSTQSEASNETnsspGTENASQAdtEDLDLSKEDLTKLvlekEELLKSKDEEVKDMKDKVLRSY 154
Cdd:PRK14144    3 KQNKKDWKKFKDEHKEEHKVENEILEE----ETDEESQH--QEPALGHPSYTAL----EEQLTLAEQKAHENWEKSVRAL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 155 AEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRASsvvkesfsKIDTSNESAeavkllnTLLEGVEMTEKQLGEV 234
Cdd:PRK14144   73 AELENVRRRMEREVANAHKYGVEKLISALLPVVDSLEQAL--------QLADKNSDP-------SMHEGLELTMKLFLDA 137

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 235 FKKFGVEKFDPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGVT 294
Cdd:PRK14144  138 LQKFDVEQIDPLGQTFDPQQHEAMSMQPAPGAPPNSVITVFQKGYKLSDRVIRPARVIVS 197
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 85-293 9.87e-23

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 93.36  E-value: 9.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  85 TEDGVNKSTQSEASNETNSSPGTENASQADTEDLDLSKE--DLTKlvlekeellkskdeEVKDMKDKVLRSYAEMENVIA 162
Cdd:PRK14162    9 EKDLPQEETTDEAPKKEAKEAPKEEDQEKQNPVEDLEKEiaDLKA--------------KNKDLEDKYLRSQAEIQNMQN 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 163 RTKRESDNAKKYAVQGFSKSLLDVADNLSRASSVvkesfskiDTSNESAEAVKllntllEGVEMTEKQLGEVFKKFGVEK 242
Cdd:PRK14162   75 RYAKERAQLIKYESQSLAKDVLPAMDNLERALAV--------KADDEAAKQLK------KGVQMTLDHLVKALKDHGVTE 140

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1002293392 243 FDPLNEKFDPNKHAALFQIP-DPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14162  141 IKADGEKFDPTLHQAVQTVAaENDDQKDHVVQVLQKGYQYKDRTLRPAMVVV 192
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 79-293 1.43e-22

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 92.63  E-value: 1.43e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  79 KAANKQTEDGVNKSTQSEASNETNSSPGTENASQADTEDLDLSKEDLtklvlekeellkskDEEVKDMKDKVLRSYAEME 158
Cdd:PRK14149    2 KDEHNQEHDHLSQKEPESEEKACACKEQQGEEKQEASEKEGEIKEDF--------------ELKYKEMHEKYLRVHADFE 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 159 NVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRAssvvkesfskidtsNESAEAVKLLNTLLEGVEMTEKQLGEVFKKF 238
Cdd:PRK14149   68 NVKKRLERDKSMALEYAYEKIALDLLPVIDALLGA--------------LKSAAEVDKESALTKGLELTMEKLHEVLARH 133

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1002293392 239 GVEKFdPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14149  134 GIEGI-ECLEEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSI 187
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 111-293 2.44e-21

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 89.73  E-value: 2.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 111 SQADTEDLDLSKEDLTKLvleKEELLKSKDEEvkdmKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNL 190
Cdd:PRK10325   30 PEASAEQVDPRDEKIANL---EAQLAEAQTRE----RDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 191 SRASSVVkesfskiDTSNESAEAvkllntLLEGVEMTEKQLGEVFKKFGVEKFDPLNEKFDPNKHAALFQIPDPSKPSGT 270
Cdd:PRK10325  103 DRALEVA-------DKANPDMSA------MVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGN 169

                         170       180
                  ....*....|....*....|...
gi 1002293392 271 VAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK10325  170 VLGIMQKGYTLNGRTIRAAMVTV 192
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 91-293 8.10e-21

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 88.06  E-value: 8.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  91 KSTQSEASNETNSSPGTENASQADTEDLDLSKEDLTKlVLEKEELLKSKDEEVKDMKDKVLRSYAEMENVIARTKRESDN 170
Cdd:PRK14158    5 KHGSHQIAEALKAKAAKEAEAAQGKPEAAQPVAAADR-IKELEEALAAKEAEAAANWDKYLRERADLENYRKRVQKEKEE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 171 AKKYAVQGFSKSLLDVADNLSRAssvvkesfskIDTSN-ESAEAVkllntlLEGVEMTEKQLGEVFKKFGVEKFD-PLNE 248
Cdd:PRK14158   84 LLKYGNESLILEILPAVDNMERA----------LDHADeESMSAI------IEGIRMTLSMLLSTLKKFGVTPVEaEKGT 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1002293392 249 KFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14158  148 PFDPAYHQAMCQVESAEQEPNTVVAVFQKGYLLNERLLRPAMVSV 192
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 131-293 6.50e-20

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 85.13  E-value: 6.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 131 EKEELLKSKDEevkdMKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRASSVvkesfskiDTSNES 210
Cdd:PRK14159   31 EQNKLQKDYDE----LKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEAAVNV--------ECHDEI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 211 AEAVKllntllEGVEMTEKQLGEVFKKFGVEKFDPLNEkFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAE 290
Cdd:PRK14159   99 SLKIK------EGVQNTLDLFLKKLEKHGVALIKEEKE-FDPNLHEAMFHVDSENHQSGEVVQVLQKGYKIADRVIRPTK 171


                  ...
gi 1002293392 291 VGV 293
Cdd:PRK14159  172 VSV 174
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 71-293 1.33e-19

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 85.93  E-value: 1.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  71 SSAPQQDDKAANKQTEDGVNKSTQSEASNETNSSPGTENASQADTEDLDLSKEDLTKLVLEKEELLKSKDEEVKDMKDKV 150
Cdd:PRK14143   11 KLAVISESEAEDNSPESSEEVTEQEAELTNPEGDAAEAESSPDSGSAASETAADNAARLAQLEQELESLKQELEELNSQY 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 151 LRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRASSvvkesfsKIDTSNESAEAvklLNTLLEGVEmteKQ 230
Cdd:PRK14143   91 MRIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERARQ-------QLKPEGEEAQA---LHRSYQGLY---KQ 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1002293392 231 LGEVFKKFGVEKFDPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14143  158 LVDVLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPEDVVLEELQRGYHLGGRVLRHAMVKV 220
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 77-294 6.71e-19

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 83.27  E-value: 6.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  77 DDKAANKQTEDGVNKSTQSEASNETNSSPGTENASQADTEDLDLSKEDLTKLVLEKEELLKSKDE----EVKDMKDKVLR 152
Cdd:PRK14160    7 DAKHENMEEDCCKENENKEEDKGKEEDLEFEEIEKEEIIEDSEESNEVKIEELKDENNKLKEENKklenELEALKDRLLR 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 153 SYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRASSVvkesfskidtsNESAEAVKllntllEGVEMTEKQLG 232
Cdd:PRK14160   87 TVAEYDNYRKRTAKEKEGIYSDACEDVLKELLPVLDNLERAAAV-----------EGSVEDLK------KGIEMTVKQFK 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002293392 233 EVFKKFGVEKFDPLNEkFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGVT 294
Cdd:PRK14160  150 TSLEKLGVEEISTEGE-FDPNLHNAVMHVEDENYGENEIVEVFQKGYKRGDKVIRYSMVKVA 210
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 70-293 3.92e-18

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 81.32  E-value: 3.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  70 SSSAPQQDDKAANKQTEDGVNKSTQSEASNETNSSPGTENASQADTEdldlskedltkLVLEKEelLKSKDEEVKDMKDK 149
Cdd:PRK14146   10 SEEAKANEKKSQSQTLEESKLENMNSEESQTITEETQEQAVEGAETE-----------TSLQKE--LDNAKKEIESLKDS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 150 VLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRASSvvkesfskidTSNESAEavklLNTLLEGVEMTEK 229
Cdd:PRK14146   77 WARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERVGA----------TQNQSEE----LKPFVEGVKMILK 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002293392 230 QLGEVFKKFGVEKFDPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHD----RVLRPAEVGV 293
Cdd:PRK14146  143 EFYSVLEKSNVIRFDPKGEPFDPMSMEALSSEEGDQYSEETVIDVYQAGYYYKEnedkFTLRPARVRI 210
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 114-293 9.00e-18

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 79.22  E-value: 9.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 114 DTEDLDLSKEDLTKLVLEKEELlkskDEEVKDMKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRA 193
Cdd:PRK14147    9 DSEDLAQNPPETDPLKAEVESL----RSEIALVKADALRERADLENQRKRIARDVEQARKFANEKLLGELLPVFDSLDAG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 194 SSVVKESFSKidtsnesaeavkllntLLEGVEMTEKQLGEVFKKFGVEKFDPLNEKFDPNKHAALFQIPDPSKPSGTVAA 273
Cdd:PRK14147   85 LTAAGTEPSP----------------LRDGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQ 148

                         170       180
                  ....*....|....*....|
gi 1002293392 274 VVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14147  149 VFQKGYLLNERLLRPALVVV 168
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 121-293 1.18e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 79.11  E-value: 1.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 121 SKEDLTKLVLEKEELLKSkDEEVKDMKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRASSVvkes 200
Cdd:PRK14156   22 TVEEVVEETPEKSELELA-NERADEFENKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAKAILPSLDNLERALAV---- 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 201 fskidtsnesaeaVKLLNTLLEGVEMTEKQLGEVFKKFGVEKFDPlnEKFDPNKHAALFQIP-DPSKPSGTVAAVVKVGY 279
Cdd:PRK14156   97 -------------EGLTDDVKKGLEMVQESLIQALKEEGVEEVAV--DSFDHNLHMAVQTLPaDDEHPADSIAQVFQKGY 161

                         170
                  ....*....|....
gi 1002293392 280 MLHDRVLRPAEVGV 293
Cdd:PRK14156  162 KLHERLLRPAMVVV 175
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 70-293 7.79e-17

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 78.07  E-value: 7.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  70 SSSAPQQDDKAANKQTEDGVNKSTQSEASNETNSSPGTENASQADTEDLDLSKED-LTKLVLEKEEllkskdeeVKDMKD 148
Cdd:PRK14157   27 QASSGADASAESGEQQDSAAQADANAGADAAPAAAEGEAKAAAEKTGEAQSDSDDtLTPLGQAKKE--------AAEYLE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 149 KVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRassvVKESfSKIDTSNESAEAvkllntllegvemte 228
Cdd:PRK14157   99 ALQRERAEFINYRNRTQKEQDRFRQHGIIDVLTALLPALDDIDR----IREH-SEMDDSFKAVAA--------------- 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002293392 229 kQLGEVFKKFGVEKFDPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14157  159 -KIDKAFEKFGVEKFGEKGEDFDPTKHDAILHKPDPDAEKETVDTVVEAGYRIGDRVIRAARVVV 222
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 87-293 3.57e-16

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 75.34  E-value: 3.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  87 DGVNKSTQSEASNETNSSPGTENASQADTEDLDLSKEDLTKLVLEKEEL---LKSKDEEVKDMKDKVLRSYAEMENVIAR 163
Cdd:PRK14145    2 EEVEKEINKEEEKDVNNLSSNEQMEGPPEDEQAQQNQPQQQTVDEIEELkqkLQQKEVEAQEYLDIAQRLKAEFENYRKR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 164 TKRESDNAKKYAVQGFSKSLLDVADNLSRAssvvkesfskIDTSNESaeavkllNTLLEGVEMTEKQLGEVFKKFGVEKF 243
Cdd:PRK14145   82 TEKEKSEMVEYGKEQVILELLPVMDNFERA----------LASSGDY-------NSLKEGIELIYRQFKKILDKFGVKEI 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1002293392 244 DPLNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14145  145 EAEGQIFDPYKHHAVMQEEVEGKQPNEIIEVFQKGYYLKDKVIRPSLVKV 194
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 75-293 1.80e-11

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 62.45  E-value: 1.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  75 QQDDKAANKQTEDGVNKStqseASNETNSSPGTENASQADTEDLDLSKEDLtklvlekeellkskDEEVKDMKdkvlRSY 154
Cdd:PRK14163   10 EKPDVPSGATPDDAEPKA----ASEEGAAPAGDAAATAGLTAQLDQVRTAL--------------GERTADLQ----RLQ 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 155 AEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRAssvvkesfskidtsNESAEAVKLLNTLLEGVEMTEKQLGev 234
Cdd:PRK14163   68 AEYQNYRRRVERDRVTVKEIAVANLLSELLPVLDDVGRA--------------REHGELVGGFKSVAESLETTVAKLG-- 131

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002293392 235 FKKFGVEkfdplNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14163  132 LQQFGKE-----GEPFDPTIHEALMHSYAPDVTETTCVAILQPGYRIGERTIRPARVAV 185
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 70-293 1.33e-10

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 59.82  E-value: 1.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  70 SSSAPQQDDKAANKQtedgvNKSTQSEASNETNSSPGTENAsQADTEDLDL-SKEDLtklvlekEELLKSKDEEVKDMKD 148
Cdd:PRK14154    7 SKNNPESETKAKNKW-----EKVMEAEEEQEEGGGDGSQEM-EPHREGLEFpSREKL-------EGQLTRMERKVDEYKT 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 149 KVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLsrassvvkesfskIDTSNESAEAVKLLNTLLEGVEMTE 228
Cdd:PRK14154   74 QYLRAQAEMDNLRKRIEREKADIIKFGSKQLITDLLPVADSL-------------IHGLESPASEDPQVKSMRDGMSLTL 140

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002293392 229 KQLGEVFKKFGVEKFDP-LNEKFDPNKHAALFQIPDPSKPSGTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14154  141 DLLHNTLAKHGVQVINPnPGDPFDPALHEAMSVQAVPDAKPDTIIQVLQKGYQLNGRVLRAARVIV 206
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 73-291 6.88e-05

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 43.25  E-value: 6.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  73 APQQDDKAANKQTEDGVNKSTQSEASNETNSSPGTENASQADTEDLDLSKEDLTKLV---LEKEELLKSKDEEVKDMKDK 149
Cdd:PRK14164   13 DPENTDPEATSADRAEAAAEEAALAQGVPEDDPFGDAVEGEIDPDLEADLEDLLDDVdpeLADDGEASTVEAQLAERTED 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 150 VLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRAssvvkESFSKIDTSNESAEAVKLlNTLLEGVemtek 229
Cdd:PRK14164   93 LQRVTAEYANYRRRTERERQAIIETAKAGVATDLLPILDDLDLA-----EQHGDLNEGPLKAFSDKL-TNVLAGL----- 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002293392 230 qlgevfkkfGVEKFDPLNEKFDPNKHAAlfqIPDPSkpSG---TVAAVVKVGYMLHDRVLRPAEV 291
Cdd:PRK14164  162 ---------KVEKFGEEGDAFDPEIHEA---VQDLS--SGdekVLGTVLRKGYRMGDRVLRTAMV 212
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 139-293 5.70e-04

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 40.37  E-value: 5.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392 139 KDEEVKDMKDKVLRSYAEMENVIARTKRESDNAKKYAVQGFSKSLLDVADNLSRAssvvkESFSKIDTSNESAEAVKLLN 218
Cdd:PRK14142   45 TEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERA-----RKHGDLESGPLKSVADKLDS 119

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002293392 219 TLlegvemteKQLGEVfkKFGVEkfdplNEKFDPNKHAALFQIPDP---SKPsgTVAAVVKVGYMLHDRVLRPAEVGV 293
Cdd:PRK14142  120 AL--------TGLGLV--AFGAE-----GEDFDPVLHEAVQHEGDGgqgSKP--VIGTVMRQGYQLGEQVLRHALVGV 180
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 81-253 3.72e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 39.26  E-value: 3.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392   81 ANKQTEDGVNKSTQSEASNETNSSPGTENASQADT-EDLDLSKEDLTKLVLEKEELLKSKDEeVKDMKDKVLRSYAEMEN 159
Cdd:TIGR01612  775 AKEKDELNKYKSKISEIKNHYNDQINIDNIKDEDAkQNYDKSKEYIKTISIKEDEIFKIINE-MKFMKDDFLNKVDKFIN 853

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002293392  160 VIARTKRESDNAKKYAVQGFSKSLLDVADN-LSRASSVVKESFSKIDTSNESAEA-VKLLNTL--LEGVEMTEKQLGEVF 235
Cdd:TIGR01612  854 FENNCKEKIDSEHEQFAELTNKIKAEISDDkLNDYEKKFNDSKSLINEINKSIEEeYQNINTLkkVDEYIKICENTKESI 933

                          170
                   ....*....|....*...
gi 1002293392  236 KKFGvEKFDPLNEKFDPN 253
Cdd:TIGR01612  934 EKFH-NKQNILKEILNKN 950
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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