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Conserved domains on  [gi|1002288596|ref|XP_015648591|]
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4-hydroxybenzoate polyprenyltransferase, mitochondrial [Oryza sativa Japonica Group]

Protein Classification

4-hydroxybenzoate octaprenyltransferase( domain architecture ID 10791469)

4-hydroxybenzoate octaprenyltransferase catalyzes the conversion of 4-hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate in a Mg2+-sensitive manner

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 130-418 0e+00

4-hydroxybenzoate nonaprenyltransferase


:

Pssm-ID: 178405  Cd Length: 289  Bit Score: 533.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 130 WLPQAARPYAMLARLDKPIGTWLLAWPCFWSISMAAMPGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTK 209
Cdd:PLN02809    1 YLPPSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPPGSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 210 SRPFASGILTPTQGVGFLGLQLLLGLGILLQLNNYSRILGASSLFLVFSYPLMKRFTFWPQAYLGLTFNWGALLGWAAIK 289
Cdd:PLN02809   81 LRPIASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 290 ESLDPAIILPLYTAGICWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDLTKHWISGFGVACIGSLALSGYSADLAWPYYP 369
Cdd:PLN02809  161 GSLDPAVVLPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1002288596 370 FLAAASAQLAWQISTVDLSDRLDCNRKFVSNKWFGALIFGGVLCGRLVS 418
Cdd:PLN02809  241 GLAAAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKLFS 289
 
Name Accession Description Interval E-value
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 130-418 0e+00

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 533.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 130 WLPQAARPYAMLARLDKPIGTWLLAWPCFWSISMAAMPGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTK 209
Cdd:PLN02809    1 YLPPSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPPGSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 210 SRPFASGILTPTQGVGFLGLQLLLGLGILLQLNNYSRILGASSLFLVFSYPLMKRFTFWPQAYLGLTFNWGALLGWAAIK 289
Cdd:PLN02809   81 LRPIASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 290 ESLDPAIILPLYTAGICWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDLTKHWISGFGVACIGSLALSGYSADLAWPYYP 369
Cdd:PLN02809  161 GSLDPAVVLPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1002288596 370 FLAAASAQLAWQISTVDLSDRLDCNRKFVSNKWFGALIFGGVLCGRLVS 418
Cdd:PLN02809  241 GLAAAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKLFS 289
ubiA_proteo TIGR01474
4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of ...
 136-416 4.46e-111

4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 130539  Cd Length: 281  Bit Score: 327.35  E-value: 4.46e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 136 RPYAMLARLDKPIGTWLLAWPCFWSISMAAMPGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFAS 215
Cdd:TIGR01474   2 LPYAKLMRADKPIGTLLLLWPCLWSLLLAAQAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLAS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 216 GILTPTQGVGFLGLQLLLGLGILLQLNNYSRILGASSLFLVFSYPLMKRFTFWPQAYLGLTFNWGALLGWAAIKESLDPA 295
Cdd:TIGR01474  82 GAVSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLSTA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 296 IILpLYTAGICWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDLTKHWISGFGVACIGSLALSGYSADLAWPYYPFLAAAS 375
Cdd:TIGR01474 162 AWV-LYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAAA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1002288596 376 AQLAWQISTVDLSDRLDCNRKFVSNKWFGALIFGGVLCGRL 416
Cdd:TIGR01474 241 LLLIRQIATLDIRDPENCLKLFKANNYVGLLLFAGIALGWL 281
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 142-414 2.35e-110

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 325.19  E-value: 2.35e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 142 ARLDKPIGTWLLAWPCFWSISMAAMPGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGILTPT 221
Cdd:cd13959     1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLPLLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 222 QGVGFLGLQLLLGLGILLQLNNYSRILGASSLFLVFSYPLMKRFTFWPQAYLGLTFNWGALLGWAAIKESLDPAIILpLY 301
Cdd:cd13959    81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSLPLPALL-LY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 302 TAGICWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDLTKHWISGFGVACIGSLALSGYSADLAWPYYPFLAAAsAQLAWQ 381
Cdd:cd13959   160 LAVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLFVALLLLAGGLAGLGWPYYLGLGAA-AHLLWQ 238

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1002288596 382 ISTVDLSDRL-DCNRKFVSNKWFGALIFGGVLCG 414
Cdd:cd13959   239 EHRLDLPDPLrSCLAFFLSNGWVGLLLFAGLLLD 272
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 136-412 9.75e-72

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 226.65  E-value: 9.75e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 136 RPYAMLARLDKPIGTWLLAWPCFWSISMAAmpGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFAS 215
Cdd:COG0382     1 RAYLRLLRLDRPIGILLLLWPTLWALFLAA--GGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLAS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 216 GILTPTQGVGFLGLQLLLGLGILLQLNNYSRILGASSLFLVFSYPL-MKRFTFWPQAYLGLTFNWGALLGWAAIKESLDP 294
Cdd:COG0382    79 GRISLREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLfLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 295 AIILpLYTAGICWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDLTKHWISG-FGVACIGSLALSGYSADLAWPYYPFLAA 373
Cdd:COG0382   159 SAWL-LALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGvLYALAVLLLLLLGLLAGLGLLYLLGLLA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1002288596 374 AsAQLAWQISTVDLS----DRLDCNRKFVSNKWFGALIFGGVL 412
Cdd:COG0382   238 A-LLLLYLSQLWLLRprkkDPARALKLFKLNMLLGLLLFLGIA 279
UbiA pfam01040
UbiA prenyltransferase family;
153-397 6.55e-45

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 156.23  E-value: 6.55e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 153 LAWPCFWSISMAAmpGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGILTPTQGVGFLGLQLL 232
Cdd:pfam01040   1 LLIPALAGLALAA--GGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 233 LGLGILLQLNNYSRILGASSLFLVFSYPL-MKRFTFWPQAYLGLTFNWGALLGWAAIKESLDPAIILpLYTAGICWTLVY 311
Cdd:pfam01040  79 LGLLLLLLLNPLTALLGLAALLLYVLYTLrLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALL-LALALFLWTWAI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 312 DTIYAHQDKEDDLKVGVKSTALRFGD-LTKHWISGFGVACIGSLALSGYSADLAWPYYPFLAAASAQLAWQISTVDLSDR 390
Cdd:pfam01040 158 ALANDLRDREDDRKAGIKTLPVVLGRkAARILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDP 237


                  ....*..
gi 1002288596 391 LDCNRKF 397
Cdd:pfam01040 238 KKDAKAF 244
 
Name Accession Description Interval E-value
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 130-418 0e+00

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 533.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 130 WLPQAARPYAMLARLDKPIGTWLLAWPCFWSISMAAMPGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTK 209
Cdd:PLN02809    1 YLPPSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPPGSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 210 SRPFASGILTPTQGVGFLGLQLLLGLGILLQLNNYSRILGASSLFLVFSYPLMKRFTFWPQAYLGLTFNWGALLGWAAIK 289
Cdd:PLN02809   81 LRPIASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 290 ESLDPAIILPLYTAGICWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDLTKHWISGFGVACIGSLALSGYSADLAWPYYP 369
Cdd:PLN02809  161 GSLDPAVVLPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1002288596 370 FLAAASAQLAWQISTVDLSDRLDCNRKFVSNKWFGALIFGGVLCGRLVS 418
Cdd:PLN02809  241 GLAAAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKLFS 289
ubiA_proteo TIGR01474
4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of ...
 136-416 4.46e-111

4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 130539  Cd Length: 281  Bit Score: 327.35  E-value: 4.46e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 136 RPYAMLARLDKPIGTWLLAWPCFWSISMAAMPGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFAS 215
Cdd:TIGR01474   2 LPYAKLMRADKPIGTLLLLWPCLWSLLLAAQAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLAS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 216 GILTPTQGVGFLGLQLLLGLGILLQLNNYSRILGASSLFLVFSYPLMKRFTFWPQAYLGLTFNWGALLGWAAIKESLDPA 295
Cdd:TIGR01474  82 GAVSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLSTA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 296 IILpLYTAGICWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDLTKHWISGFGVACIGSLALSGYSADLAWPYYPFLAAAS 375
Cdd:TIGR01474 162 AWV-LYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAAA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1002288596 376 AQLAWQISTVDLSDRLDCNRKFVSNKWFGALIFGGVLCGRL 416
Cdd:TIGR01474 241 LLLIRQIATLDIRDPENCLKLFKANNYVGLLLFAGIALGWL 281
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 142-414 2.35e-110

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 325.19  E-value: 2.35e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 142 ARLDKPIGTWLLAWPCFWSISMAAMPGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGILTPT 221
Cdd:cd13959     1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLPLLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 222 QGVGFLGLQLLLGLGILLQLNNYSRILGASSLFLVFSYPLMKRFTFWPQAYLGLTFNWGALLGWAAIKESLDPAIILpLY 301
Cdd:cd13959    81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSLPLPALL-LY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 302 TAGICWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDLTKHWISGFGVACIGSLALSGYSADLAWPYYPFLAAAsAQLAWQ 381
Cdd:cd13959   160 LAVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLFVALLLLAGGLAGLGWPYYLGLGAA-AHLLWQ 238

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1002288596 382 ISTVDLSDRL-DCNRKFVSNKWFGALIFGGVLCG 414
Cdd:cd13959   239 EHRLDLPDPLrSCLAFFLSNGWVGLLLFAGLLLD 272
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 136-412 9.75e-72

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 226.65  E-value: 9.75e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 136 RPYAMLARLDKPIGTWLLAWPCFWSISMAAmpGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFAS 215
Cdd:COG0382     1 RAYLRLLRLDRPIGILLLLWPTLWALFLAA--GGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLAS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 216 GILTPTQGVGFLGLQLLLGLGILLQLNNYSRILGASSLFLVFSYPL-MKRFTFWPQAYLGLTFNWGALLGWAAIKESLDP 294
Cdd:COG0382    79 GRISLREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLfLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 295 AIILpLYTAGICWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDLTKHWISG-FGVACIGSLALSGYSADLAWPYYPFLAA 373
Cdd:COG0382   159 SAWL-LALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGvLYALAVLLLLLLGLLAGLGLLYLLGLLA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1002288596 374 AsAQLAWQISTVDLS----DRLDCNRKFVSNKWFGALIFGGVL 412
Cdd:COG0382   238 A-LLLLYLSQLWLLRprkkDPARALKLFKLNMLLGLLLFLGIA 279
UbiA pfam01040
UbiA prenyltransferase family;
153-397 6.55e-45

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 156.23  E-value: 6.55e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 153 LAWPCFWSISMAAmpGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGILTPTQGVGFLGLQLL 232
Cdd:pfam01040   1 LLIPALAGLALAA--GGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 233 LGLGILLQLNNYSRILGASSLFLVFSYPL-MKRFTFWPQAYLGLTFNWGALLGWAAIKESLDPAIILpLYTAGICWTLVY 311
Cdd:pfam01040  79 LGLLLLLLLNPLTALLGLAALLLYVLYTLrLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALL-LALALFLWTWAI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 312 DTIYAHQDKEDDLKVGVKSTALRFGD-LTKHWISGFGVACIGSLALSGYSADLAWPYYPFLAAASAQLAWQISTVDLSDR 390
Cdd:pfam01040 158 ALANDLRDREDDRKAGIKTLPVVLGRkAARILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDP 237


                  ....*..
gi 1002288596 391 LDCNRKF 397
Cdd:pfam01040 238 KKDAKAF 244
ubiA PRK12873
4-hydroxybenzoate polyprenyltransferase;
136-416 1.20e-35

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 171787 [Multi-domain]  Cd Length: 294  Bit Score: 132.86  E-value: 1.20e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 136 RPYAMLARLDKPIGTWLLAWPCFWSISMAamPGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFAS 215
Cdd:PRK12873    8 SPWFELLRWNKPTGRLILLIPAGWSLWLT--PSAPPSLLLLLLIILGGLAVSGAGCIANDLWDRRIDRKVERTKNRPLAR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 216 GILTPTQGVGFLGLQLLLGLGILLQLNNYSRILGAS----SLFLVFSYPLMKRFTFWPQAYLGLTFNWGALLGWAAIKES 291
Cdd:PRK12873   86 GKISLKTAYSLLIVLLLLSLFVVLSLPQPSRNLCLSlaflALPPILIYPSAKRWFAYPQAILALCWGFAVLIPWAAAEGS 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 292 LDPAIIL-PLYTAGICWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDLTKHWIS-GFGVACIGsLALSGYSADLAWPYYP 369
Cdd:PRK12873  166 LNGGWPLlFCWLATLLWTFGFDTVYAMADRRDDAKIGLNSSALSLGSNALKTVQiCYFLTSIF-LALAAFIAQVGFIFWP 244

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1002288596 370 FLAAASaqLAWQISTVDLSDRLDCNRK----FVSNKWFGALIFGGVLCGRL 416
Cdd:PRK12873  245 FWLIAS--IGMQRDILKLFPEKQSIKTignhFSNQVILGSLLLLGLILARG 293
ubiA PRK12886
prenyltransferase; Reviewed
 168-417 4.54e-17

prenyltransferase; Reviewed


Pssm-ID: 237247  Cd Length: 291  Bit Score: 80.89  E-value: 4.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 168 GELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGILTPTQGVGFLGLQLLLGLGILLQLNNYSRI 247
Cdd:PRK12886   36 LGLPGASQLDWILMAMVGARTAAMGFNRLIDAEIDARNPRTAGRAIPAGLISKGSAILFIVLSSLLMLFAAWFLNPLCLY 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 248 LGASSLFLVFSYPLMKRFTFWPQAYLGLTFNWGALLGWAAIKESLD-PAIILPLytAGICWTLVYDTIYAHQDKEDDLKV 326
Cdd:PRK12886  116 LSPPALFFLLLYSYCKRFTALAHVVLGFCLALAPLGAWIAIRGTIElPAILLGL--AVLFWVAGFDILYALQDLEFDRKE 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 327 GVKSTALRFGDLTKHWIS-GFGVACIGSLALSGYSADLAWPYYPFLAAASAQLA---WQISTVDLSdRLDCnRKFVSNKW 402
Cdd:PRK12886  194 GLHSIPAKLGVNGSLWIArVFHLLMIGFLFALGISAGLGPWFLAGLAVTGILLLyehWLLRGGDLT-RLDA-AFFNMNGY 271

                         250
                  ....*....|....*
gi 1002288596 403 FGALIFGGVLCGRLV 417
Cdd:PRK12886  272 ISVTLFAATLFDRLF 286
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 142-412 8.29e-17

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 80.08  E-value: 8.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 142 ARLDKPIGTWLLAWPCFWSISMAAMPGELPDMRMLALFGcGAVLLRGAGCTVNDLLDRDIDNkvERTKSRPFASGILTPT 221
Cdd:cd13956     1 LRLMRPYTLLYVLAPALAGAALAGAFAGPLPALLLLALL-AVFLGAGAGYALNDYTDRELDA--INKPDRPLPSGRLSPR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 222 QGVGFLGLQLLLGLGILLQLNNYSRILGASSLFLVFSYPLM-KRFTFWPQAYLGLTFNWGALLGWAAIKESLDPAIILPL 300
Cdd:cd13956    78 QALAFAAALLLVGLALALALGPLALLLLLAGLLLGLAYSLGlKRLKLGGWGVLGYATGLALLPGLGAVAAGGLVPLALLL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 301 YTAGICWTLVYDTIYAHQDKEDDLKVGVKSTALRFG-DLTKHWISGFGVACIGSLALSGYSADLAWPYYPFLAAASAqLA 379
Cdd:cd13956   158 ALVFLLLGLGINLYNDLPDVEGDRAAGIRTLPVRLGpRRARRLAAGLLLAALILVVLLAVAGLLGPLALLALLAVAL-LA 236

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1002288596 380 WQISTVDLSDRLDCNRKFVSNKWFGALIFGGVL 412
Cdd:cd13956   237 LRARFARADRLPALPRGFLLLAVYRLLLFAALL 269
ubiA PRK12888
4-hydroxybenzoate octaprenyltransferase;
174-409 6.06e-16

4-hydroxybenzoate octaprenyltransferase;


Pssm-ID: 183814  Cd Length: 284  Bit Score: 77.45  E-value: 6.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 174 RMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGILTPTQGVGFLGLQLLLGLGILLQLNNYSRILGASSL 253
Cdd:PRK12888   39 ADLLLVTVAMVGARTFAMAANRIIDREIDARNPRTAGRELVTGAVSVRTAWTGALVALAVFLGAAALLNPLCLALAPLAV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 254 FLVFSYPLMKRFTFWPQAYLGLTFNWGALLGWAAIKESLD-PAIILPLytAGICWTLVYDTIYAHQDKEDDLKVGVKSTA 332
Cdd:PRK12888  119 APLVVYPYAKRFTNFPHAILGLAQAVGPVGAWIAVTGTWSwPAVLLGL--AVGLWIGGFDLIYACQDAEVDRRIGVRSVP 196

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002288596 333 LRFG-DLTKHWISGFGVACIGSLALSGYSADLAWPYYPFLAAASAQLAWQISTVDLSDRLDCNRKFVS-NKWFGALIFG 409
Cdd:PRK12888  197 ARFGvRAALWASRVAHVVTFALFVWFGLAVGFGALWWIGLAITAGAFAYEHAIVSPTDLSRVNRAFFTaNGFVGIALFG 275
ubiA PRK13106
prenyltransferase; Reviewed
 158-381 2.01e-13

prenyltransferase; Reviewed


Pssm-ID: 237283  Cd Length: 300  Bit Score: 70.53  E-value: 2.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 158 FWSISMAAM-----PGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGILTPTQGVGFLGLQLL 232
Cdd:PRK13106   28 FFSLPMAYLgafvaIKGIPPISTLILIFLALFFLRTAGMTNDNLADLEIDAKNPRTKNRPLVTGAIKISEAKALITAGLI 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 233 LGLGILLQLNNYSRILGASSLFLVFSYPLMKRFTFWPQAYLGLTFNWGALLGWAAIKESLDPAIILPLYT-------AGI 305
Cdd:PRK13106  108 LFFASAYLVNRWALLLSPIVALIAMSYPYMKRYTAFANYHLASIQGLAVFSGAVAVLGLYANSLIQVLLRvpwlfviGTI 187

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002288596 306 CWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDLTKHWISGFGVACIGSLALSGYSADLAWPYYPFLAAASAQLAWQ 381
Cdd:PRK13106  188 LWAAGFDLYNHIPDAEFDREMGLHSFAVVLGKWALTFAGLNQLFSVVLDLLGDLYYGLGPIAIAATILHGLIMAYA 263
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 146-298 5.48e-11

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 439879  Cd Length: 299  Bit Score: 63.23  E-value: 5.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 146 KPIGTWLLAWPCFwsISMAAMPGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGILTPTQGVG 225
Cdd:COG0109    24 KPRIILLLLFTAL--AGMLLAAGGLPDLLLLLLTLLGGALAAGAANALNNYIDRDIDALMKRTKNRPLPTGRISPREALI 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 226 FLGLQLLLGLGILLQLNN-YSRILGASSLFL-VFSY-PLMKRFTfwPQAylglTFnWGA-------LLGWAAIKESLDPA 295
Cdd:COG0109   102 FGLVLGVLGLALLALFVNpLAALLGLLGIFFyVVVYtLWLKRRT--PQN----IV-IGGaagamppLIGWAAVTGSLSLE 174


                  ...
gi 1002288596 296 IIL 298
Cdd:COG0109   175 ALL 177
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 146-298 8.32e-10

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 59.38  E-value: 8.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 146 KPIGTWLLAWPCFwsISMAAMPGELPDMRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGILTPTQGVG 225
Cdd:cd13957     5 KPRITLLVLLTAL--AGYLLAPGGVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKHALI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 226 FLGLQLLL-GLGILLQLNNYSRILGASSLFL-VFSY-PLMKRFTFWpqaylgltfN--WGA-------LLGWAAIKESLD 293
Cdd:cd13957    83 FGLVLGILgLALLALFVNPLTALLGLLGIFLyVFVYtPLKKRTTPL---------NtvIGGiagaippLIGWAAATGSLD 153


                  ....*
gi 1002288596 294 PAIIL 298
Cdd:cd13957   154 LGAWL 158
ubiA PRK12874
4-hydroxybenzoate polyprenyltransferase;
183-346 7.29e-09

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 237242  Cd Length: 291  Bit Score: 56.55  E-value: 7.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 183 AVLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGILTPTQGVGFLGLQLLLGLGILLQLNNYSRILGASSLFLVFSYPLM 262
Cdd:PRK12874   56 AVSARNFAMAFNRLVDRDIDKDNPRTANRPSVDGRISVKSMVLFIVLNALIFIGVSYFINPLAFKLSFPFLIVLGGYSYF 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 263 KRFTFWPQAYLGLTFNWGALLGWAAIKESldpaiiLPLYTAGIC-----WTLVYDTIYAHQDKEDDLKVGVKSTALRFGD 337
Cdd:PRK12874  136 KRFSSLAHLVLGLSLGLAPIAGVVAVLGE------IPLWSVFLAlgvmfWVAGFDLLYSLQDMEFDKKRGLHSIPSKFGE 209


                  ....*....
gi 1002288596 338 LTKHWISGF 346
Cdd:PRK12874  210 KATLFISRL 218
ubiA PRK12876
prenyltransferase; Reviewed
 173-336 1.93e-08

prenyltransferase; Reviewed


Pssm-ID: 237244  Cd Length: 300  Bit Score: 55.52  E-value: 1.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 173 MRMLALFGCGAVLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGILTPTQGVGFLGLQLLLGLGILLQLNNYSRILGASS 252
Cdd:PRK12876   46 IKTISLGGSAFFCARTVGIIVNQIIDCAIDKKNPRTSSRVLPAKLLSINFSMLLLTLCSFLFLSLCWLLNPLCFSLAVLS 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 253 LFLVFSYPLMKRFTFWPQAYLGLTFNWGALLGWAAIKESldpAIILPLYTAGICWTLVY-------DTIYAHQDKEDDLK 325
Cdd:PRK12876  126 TLLMIIYPYTKRVTFLCHWILGLVYYLAILMNFFAIIET---PLSFSLFCMASLWGISFgmiiaanDIIYAIQDLEFDRK 202

                         170
                  ....*....|.
gi 1002288596 326 VGVKSTALRFG 336
Cdd:PRK12876  203 EGLFSIPARFG 213
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 165-298 4.96e-08

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 53.99  E-value: 4.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 165 AMPGELPDMRMLALFGCGAvLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGILTPTQGVGFLGLQLLLGLGILLQLNNY 244
Cdd:PRK04375   36 APPGVPPLLLLLLTLLGIA-LVAGAAGALNNYIDRDIDAKMERTKNRPLVTGRISPREALIFGLVLGVLGFLLLGLFVNP 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002288596 245 -SRILGASSLFL-VFSYPL-MKRFTfwPQaylgltfN--WGA-------LLGWAAIKESLDP-AIIL 298
Cdd:PRK04375  115 lAAWLTLAGIFFyVVVYTLwLKRRT--PQ-------NivIGGaagamppLIGWAAVTGSLSWeALIL 172
ubiA PRK12895
prenyltransferase; Reviewed
 183-408 2.17e-07

prenyltransferase; Reviewed


Pssm-ID: 237251  Cd Length: 286  Bit Score: 52.12  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 183 AVLLRGAGCTVNDLLDRDIDNKVERTKSRPFASGILTPTQGVGFLGLQLLLGLGILLQLNNYSRILGASSLFLVFSYPLM 262
Cdd:PRK12895   46 AVSARTSAMSINRIEGLRYDMINPRKKDWALVSGRIKMREAIAFTIIFIAIFEICTFLLNRLVFILSPIVIFLFIIDPFL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 263 KRFTFWPQAYLGLTFNWGALLGWAAIKESL--DPAIILpLYTAGICWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDLTK 340
Cdd:PRK12895  126 KRYTAWRHIYMGSIIGLGVLAGYLAVIPAFpyNLLIYI-IFISSSLWIAGFDIIYVIPDIEYDKINGLKTIMNTYGIKNG 204

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002288596 341 HWISG-FGVACIGSLALSGYSADLAWpYYPFLAAASAQLAWQISTVDLSDRLDCNRKFVSNKWFGALIF 408
Cdd:PRK12895  205 LYISDiFHISSLILFWISGIYIRTLW-YLAALIIIYTLVIYQHLIIDPRNPINKRMSFFNANSFIGFVF 272
PT_UbiA_UBIAD1 cd13962
1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the ...
 133-382 6.88e-04

1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260125  Cd Length: 283  Bit Score: 41.34  E-value: 6.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 133 QAARPYamlarldkpigTWLLAW-PCFWSISMAAMPGELPDMRMLALFGCGAVLLRGAGCTVNDLLD--RDIDNKVERTK 209
Cdd:cd13962     2 LAARPR-----------TLPASLaPVLLGTALAYYLGGFFNWLLFLLALLAALLLQIGVNLANDYFDykKGTDTEPRSGP 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 210 SRPFASGILTPTQ----GVGFLGLQLLLGLGILLQLNNYSRILGASSLFLVFSYplmkrfTFWP--QAYLGL-------T 276
Cdd:cd13962    71 SRVLVSGLLSPRQvlraALVLLLLAALLGLYLVALGGWLLLLLGLLGILAGYFY------TGGPfpLSYRGLgelfvflF 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 277 FNWGALLG-WAAIKESLDPAIILPlytAGICWTLVYDTIYAHQ--DKEDDLKVGVKSTALRFGD-LTKHWISGFGVACIG 352
Cdd:cd13962   145 FGLLAVLGtYYVQTGSLSWEVLLA---ALPLGLLIAAILLANNirDIEADRAAGKRTLAVRLGRkRARRLYAALLLLAYL 221

                         250       260       270
                  ....*....|....*....|....*....|
gi 1002288596 353 SLALsgYSADLAWPYYPFLAAASAQLAWQI 382
Cdd:cd13962   222 LLLL--LVLLGLLPLWSLLALLSLPLAIKL 249
PLN02776 PLN02776
prenyltransferase
 192-301 4.22e-03

prenyltransferase


Pssm-ID: 215415  Cd Length: 341  Bit Score: 38.96  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 192 TVNDLLDRDIDNKVERTKSRPFASGILTPTQGVGFLGLQLLL-GLGILLQLNNYSRILGASSLFL-VFSYPLMKRFTFWp 269
Cdd:PLN02776   47 TLNQVFEVKNDSKMKRTMRRPLPSGRISVPHAVAWAVVVGAAgVALLAYKTNMLTAGLGAGNILLyAFVYTPLKQIHPA- 125

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1002288596 270 QAYLGLTFnwGA---LLGWAAIKESLDP-AIILP--LY 301
Cdd:PLN02776  126 NTWVGAVV--GAippLMGWAAASGQLDAgAMVLAaaLY 161
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 168-374 4.94e-03

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 38.64  E-value: 4.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 168 GELPDMRMLALFGCGaVLLRGAGCTVNDLLDRDID--NKVErtksRPFASGILTPTQGVGFLGLQLLLGLGILLQLNNYS 245
Cdd:cd13961    30 LSLNDLELLLLFLSV-FLIAAAGYIINDYFDVEIDriNKPD----RPIPSGRISRREALILSILLNALGLILAFLLSPLA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 246 RILGASSLFLVFSYP-LMKRFTFWPQ---AYL-GLTFnwgaLLGWAAIKESLDPAIILPLYTAGIcwTLVYDTIYAHQDK 320
Cdd:cd13961   105 LLIALLNSLLLWLYShKLKRTPLIGNllvALLtGLPF----LFGGLAAGNLLLIILLLALFAFLI--TLGREIVKDIEDV 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1002288596 321 EDDLKVGVKSTALRFG-DLTKHWISGFGVACIGSLALSGYSADLAWPYYPFLAAA 374
Cdd:cd13961   179 EGDRAEGARTLPIVYGiKKAKKIAALLLLLAILLSPLPYLLGGLGILYLILIIIA 233
PT_UbiA_2 cd13963
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 193-277 5.72e-03

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260126  Cd Length: 278  Bit Score: 38.22  E-value: 5.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002288596 193 VNDLLDRDIDNKVERTKSRPFASGILTPTQGVGFLGlqlllglgillqlnnysrILGASSLFLVFSYPlmKRFTFWPQAY 272
Cdd:cd13963    52 LNDLLDLEADRLHPTKRNRPIASGRLSIPAALALAV------------------VLLLAGLALALLLS--PAFLLVLLAY 111


                  ....*
gi 1002288596 273 LGLTF 277
Cdd:cd13963   112 LVLNL 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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