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Conserved domains on  [gi|998707127|ref|XP_015491283|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [Parus major]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 88-331 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467704  Cd Length: 244  Bit Score: 539.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  88 GYISVLEHKPLKMHCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 167
Cdd:cd23976    1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 168 LLNMSHGAVFIFWGPSSYMRRDGKGLVYNNLQLMNQILPQLKVYMISRHKMLQFDDLFKRETGKDRKISNTWLSTGWFTM 247
Cdd:cd23976   81 LLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 248 TIALELCDRINVYGMVPPDFCRDPNHLSVPYHYYEPLGPDECTMYISHERGRKGSHHRFITEKRVFENWARTFDIHFFQP 327
Cdd:cd23976  161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPSGPDECTMYISHERGRKGSHHRFITEKRVFANWARTFNIHFYQP 240


                 ....
gi 998707127 328 DWKP 331
Cdd:cd23976  241 DWKP 244
 
Name Accession Description Interval E-value
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 88-331 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 539.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  88 GYISVLEHKPLKMHCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 167
Cdd:cd23976    1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 168 LLNMSHGAVFIFWGPSSYMRRDGKGLVYNNLQLMNQILPQLKVYMISRHKMLQFDDLFKRETGKDRKISNTWLSTGWFTM 247
Cdd:cd23976   81 LLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 248 TIALELCDRINVYGMVPPDFCRDPNHLSVPYHYYEPLGPDECTMYISHERGRKGSHHRFITEKRVFENWARTFDIHFFQP 327
Cdd:cd23976  161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPSGPDECTMYISHERGRKGSHHRFITEKRVFANWARTFNIHFYQP 240


                 ....
gi 998707127 328 DWKP 331
Cdd:cd23976  241 DWKP 244
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 92-282 5.79e-33

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 122.72  E-value: 5.79e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127   92 VLEHKPLK-MHCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVI-AHSSIQRILRNRNE-- 167
Cdd:pfam00777  32 LPKVSPFDnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFsh 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  168 --------LLNMSHG------AVFIFWGPSSYMRRdgkglVYNNLQLMNQILPQLKVYMISRHKMLQFDDLFKRETGKDR 233
Cdd:pfam00777 112 prdpfvefVLVPFKGrdllwlPAFLTKGNVSRSLR-----VLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGLKG 186

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 998707127  234 KIsntwLSTGWFTMTIALELCDRINVYGMVPPDfcrdpNHLSVPYHYYE 282
Cdd:pfam00777 187 RR----PSTGLLMLSLALHLCDEVSLYGFGPFL-----DSRGNSHHYYD 226
 
Name Accession Description Interval E-value
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 88-331 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 539.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  88 GYISVLEHKPLKMHCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 167
Cdd:cd23976    1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 168 LLNMSHGAVFIFWGPSSYMRRDGKGLVYNNLQLMNQILPQLKVYMISRHKMLQFDDLFKRETGKDRKISNTWLSTGWFTM 247
Cdd:cd23976   81 LLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 248 TIALELCDRINVYGMVPPDFCRDPNHLSVPYHYYEPLGPDECTMYISHERGRKGSHHRFITEKRVFENWARTFDIHFFQP 327
Cdd:cd23976  161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPSGPDECTMYISHERGRKGSHHRFITEKRVFANWARTFNIHFYQP 240


                 ....
gi 998707127 328 DWKP 331
Cdd:cd23976  241 DWKP 244
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 102-327 5.80e-129

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 367.72  E-value: 5.80e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 102 CKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELL-NMSHGAVFIFW 180
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAILLLaGTRAPTVVVFW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 181 GPSSYMRRDGKGlVYNNLQLMNQILPQLKVYMISRHKMLQFDDLFKRETGKDRKISNTWLSTGWFTMTIALELCDRINVY 260
Cdd:cd23965   81 GPETKMNKDGAG-KYNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVY 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 998707127 261 GMVPPDFCRDPNHLSVPYHYYEPLGPDECTMYISHERGRKGsHHRFITEKRVFENWARTFDIHFFQP 327
Cdd:cd23965  160 GMVPENYCREHPNSKVPYHYYEPGGLKECTYYNYHENALKG-GHRFITEKAVFARWAKKYNITFHHP 225
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 102-329 3.03e-124

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 356.09  E-value: 3.03e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 102 CKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELLNMSHGAVFIFWG 181
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 182 PSSYMRRDGKGLVYNNLQLMNQILPQLKVYMISRHKMLQFDDLFKRETGKDRKISNTWLSTGWFTMTIALELCDRINVYG 261
Cdd:cd23978   81 PPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 998707127 262 MVPPDFCRD-PNHLSVPYHYYEPLGPDECTMYISHERGRKGSHHRFITEKRVFENWARTFDIHFFQPDW 329
Cdd:cd23978  161 MVPPNYCSKrPTPKKMPYHYYEPKGPDECVTYIQNEHGRRGNHHRFITEKRVFARWAEHYNITFSHPSW 229
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 102-329 9.90e-98

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 288.68  E-value: 9.90e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 102 CKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELLNMSHGAVFIFWG 181
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 182 PSSYMRRDGKGLVYNNLQLMNQILPQLKVYMISRHKMLQFDDLFKRETGKDRKISNTWLSTGWFTMTIALELCDRINVYG 261
Cdd:cd23977   81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 998707127 262 MVPPDFCRDPNHLSVPYHYYEPLGPDECTMYISHERGRKGShHRFITEKRVFENWARTFDIHFFQPDW 329
Cdd:cd23977  161 MVSDSYCRNKNHSSVPYHYYEKGRLDECRMYLVHERAPRGG-HRFITEKAIFSRWAKRKKIRFAHPSW 227
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 102-329 4.30e-85

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 256.40  E-value: 4.30e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 102 CKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELLNMSHGAVFIFWG 181
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 182 PSSYMRRDGKGLVYNNLQLMNQILPQLKVYMISRHKMLQFDDLFKRETGKDRKISNTWLSTGWFTMTIALELCDRINVYG 261
Cdd:cd23975   81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 998707127 262 MVPPDFCRDPNHLSVPYHYYEPlGPDECTMYISHERGRKGShHRFITEKRVFENWARTFDIHFFQPDW 329
Cdd:cd23975  161 MINDTYCKTEGYRKVPYHYYEP-GRDECDEYFLHENAPYGG-HRFITEKKVFAKWAKKHPITFTHPNW 226
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 105-316 1.00e-39

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 138.65  E-value: 1.00e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 105 CALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRN-RNELLNMS--HGAVFIFWG 181
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGpRCGCHPLPleEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 182 PSSYMRRDGK---GLVYNNLQLMNQILPQLKVYMISRhkmlqfddlFKRETGKDRKISNTwLSTGWFTMTIALELCDRIN 258
Cdd:cd19952   81 AAAADFKRLKrrkKRHDNAVLLLTDPAPDLLSYVRKR---------LEKLGLKSFFGGNA-PSSGLLAVLLALQLCDSVD 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 998707127 259 VYGmvppdFCRDPNH-LSVPYHYYEPLGPdectmyisherGRKGSHHRFITEKRVFENW 316
Cdd:cd19952  151 LYG-----FGVDSGHaPKVPYHYYDLVEA-----------EEGTAVHSFDLEAELLRAL 193
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 103-309 1.80e-33

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 124.68  E-value: 1.80e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 103 KSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRIL------RNRNELLN-MSHGA 175
Cdd:cd23963   64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRRYnslkknRDRDKFLNrLKEYN 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 176 VFIFWGPSSYMRRDGKgLVYNNLQLMNQILPQLKV-YMISRHKMLQFDdlFKRETGKDRkisntWLSTGWFTMTIALELC 254
Cdd:cd23963  144 GSILWYPKFSFKSSTN-LLLKAARALKKNGLNLTVvYSNPEHFLAVQK--FWKRRGLEK-----RPSTGLYLVSLALTFC 215

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 998707127 255 DRINVYGMVPpdFCRDPNHLSVPYHYYEPLGPDEctmyishergrKGSHHRFITE 309
Cdd:cd23963  216 DEIHLYGFWP--FPTDPNGRPVPYHYYDDLSPST-----------KNKVHNMPEE 257
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 92-282 5.79e-33

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 122.72  E-value: 5.79e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127   92 VLEHKPLK-MHCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVI-AHSSIQRILRNRNE-- 167
Cdd:pfam00777  32 LPKVSPFDnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFsh 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  168 --------LLNMSHG------AVFIFWGPSSYMRRdgkglVYNNLQLMNQILPQLKVYMISRHKMLQFDDLFKRETGKDR 233
Cdd:pfam00777 112 prdpfvefVLVPFKGrdllwlPAFLTKGNVSRSLR-----VLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGLKG 186

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 998707127  234 KIsntwLSTGWFTMTIALELCDRINVYGMVPPDfcrdpNHLSVPYHYYE 282
Cdd:pfam00777 187 RR----PSTGLLMLSLALHLCDEVSLYGFGPFL-----DSRGNSHHYYD 226
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 103-313 1.84e-29

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 113.90  E-value: 1.84e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 103 KSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHssiQRILRNRNELLN---MSHGAVFIf 179
Cdd:cd23968   46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINS---QILSKPEFNFLTdplYRNVTLLV- 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 180 WGPSSYMRRDGKGL------VYNNLQLMNQILPQLKVYMISRHKMLQFDDLFKRETGkdRKISNTWLSTGWFTMTIALEL 253
Cdd:cd23968  122 WDPSSYNVNLEKWYkkpdfdFFPNYIKYRRRHPEEPFYLIDPRFLWRLWDILQEYTP--EKIKPNPPSSGFIGIVLMLHL 199

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 998707127 254 CDRINVYGMVPP----DFCrdpnhlsvpyHYYEPLGPDECTMyishergrkGSHHRFITEKRVF 313
Cdd:cd23968  200 CDWVDVYEYVPSvrqtDRC----------HYYDVEKDLACTL---------GAWHPLAAEKLLV 244
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 98-285 1.55e-23

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 98.23  E-value: 1.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  98 LKMHCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRIL--------RNRNELL 169
Cdd:cd23970   64 QNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYYnnlltiqdRNNFFLS 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 170 NMSHGAVfIFWGPS---SYMRRDGKGLVYNNLQLMNQILPQLKvymISRHKMLQFDDLFKRETGKDRKisntwLSTGWFT 246
Cdd:cd23970  144 LKKLDGA-ILWIPAfffHTSATVTRTLVDFFVEHRGQLKVQLA---WPGNIMQHVNRYWKTKHLSPKR-----LSTGILM 214

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 998707127 247 MTIALELCDRINVYGMVPpdFCRDPNHLSVPYHYYEPLG 285
Cdd:cd23970  215 YTLASAICEEIHLYGFWP--FGFDPTGTPLPYHYYDKKG 251
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 97-284 3.27e-23

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 97.32  E-value: 3.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  97 PLK-MHCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRN------RNELL 169
Cdd:cd23987   58 PLKnKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDlvnetwKEKFL 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 170 NMSHG-AVFIFWGPsSYMRRDGKGLV--YNNLQLMNQI-----LPQLKVYMISRHKMLQFDDLFKRETgkdrkisntwls 241
Cdd:cd23987  138 QRLQSlNGSILWIP-AFMAKGGEERVewVNDLILKHHInvrtaYPSLRLLHAVRGYWLTNKVHIKRPT------------ 204

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 998707127 242 TGWFTMTIALELCDRINVYGMVPpdFCRDPNHLSVPYHYYEPL 284
Cdd:cd23987  205 TGLLMYTLATRFCNRIHLYGFWP--FPRDQNQNPVKYHYYDSL 245
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 102-311 7.64e-23

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 94.28  E-value: 7.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 102 CKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSS--IQRILRNRNELLnmshgaVFIF 179
Cdd:cd23967    2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESafRDPEEYDSDWLL------VLVP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 180 WGPSSY-------MRRDGKGLVY-------------NNLQLMN-QILPQLKVYMISrhkmlqfddlfKRETGKDRKIsnt 238
Cdd:cd23967   76 FKSMDLlwlqaviKGKKPNGKGGfwkkiatsvpkppKKIRILNpYILQEAAFDLIG-----------LPMNGKQGKN--- 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 998707127 239 WLSTGWFTMTIALELCDRINVYGmvppdFCRDPNHLSVPYHYYEPLgpdecTMYIShergRKGSHHRFITEKR 311
Cdd:cd23967  142 VPTTGIIAIVMALHYCDEVDIAG-----FGYDPSDPNAPLHYYDSL-----TMKAI----KRSWTHNVTKEKK 200
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 77-310 8.48e-22

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 92.98  E-value: 8.48e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  77 PALPVGAGLLEGYisvlehkplkmhcKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAhs 156
Cdd:cd23986   37 PKIPLSKLHLRGF-------------RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIIN-- 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 157 siQRILRNRNELLNMS---HGAVFIFWGPSSYMRRDGKGLVYNNLQLMNQIL------PQLKVYMISRHKMLQFDDLFKR 227
Cdd:cd23986  102 --SQILTNPNHHFIDSslyKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVqyrkrnPNQPFYILHPKFIWQLWDIIQE 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 228 ETgkDRKISNTWLSTGWFTMTIALELCDRINVYGMVPP----DFCrdpnhlsvpyHYYEPLGPDECTMyishergrkGSH 303
Cdd:cd23986  180 NT--QEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSvrqtDLC----------HYHERYYDAACTL---------GAY 238


                 ....*..
gi 998707127 304 HRFITEK 310
Cdd:cd23986  239 HPLLYEK 245
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 94-313 1.43e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 92.48  E-value: 1.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  94 EHKPLK-MHCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSL-----RVIAH-------SSIQR 160
Cdd:cd23969   55 EVSPLKgKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLttmnpSVIPHaygdlvnATDKE 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 161 ILRNRNELLNMShgavfIFWGPsSYMRRDGKGLV-YNNLQLMNQILPqLKVYMISRHkMLQfddlfkretgkdrKISNTW 239
Cdd:cd23969  135 KFVERLRQLGDS-----ILWIP-AFVSKGGEEHVqWTNEIILKHKLN-VKTAYPPLR-LNH-------------AIRGYW 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 240 L---------STGWFTMTIALELCDRINVYGMVPpdFCRDPNHLSVPYHYYEPLGpdectmYIShergrKGSHHRFITEK 310
Cdd:cd23969  194 LttkfrikrpSTGLLMYTLATRFCDEIHLYGFYP--FSEDGNGRAVKYHYYDNRK------YLT-----TARPHKMPEEF 260


                 ...
gi 998707127 311 RVF 313
Cdd:cd23969  261 RAL 263
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 103-286 1.64e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 92.32  E-value: 1.64e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 103 KSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTrGYGKDVGNKTSLrVIAHSSiqrILRNRNELLNMSHGAvFI---- 178
Cdd:cd23971   65 KTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSKTNL-VTANPS---ILREKFHNLKKRRRP-FVermk 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 179 ------FWGPS-SYMRRDGKGL-VYNNLQlmnQILPQLKVYMISRHKMLQFDDLFKRETGKDRKisntwLSTGWFTMTIA 250
Cdd:cd23971  139 vygnalLLLPAfSYTSNTEPSLrALYTLE---DFGSPQKVLFFNPEYLRNLSRYWKSKGLKARR-----LSTGLMLVSAA 210

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 998707127 251 LELCDRINVYGMVPpdFCRDPNHLSVPYHYYEPLGP 286
Cdd:cd23971  211 LELCENVHLYGFWP--FSTDLDGNPISHHYYDNVLP 244
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 94-284 8.91e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 85.01  E-value: 8.91e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  94 EHKPLK-MHCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRI---LRNRNELL 169
Cdd:cd23988   55 EVSPMKnRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAfggFRNESDRE 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 170 NMSHGAVF----IFWGPsSYMRRDGKGLV--YNNLQLMNQI-----LPQLKVYMISRHKMLQFDDLFKREtgkdrkisnt 238
Cdd:cd23988  135 KFVHRLSMlndsVLWIP-AFMVKGGEKHVewVNALILKNKLkvrtaYPSLRLIHAVRGYWLTNKVNIKRP---------- 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 998707127 239 wlSTGWFTMTIALELCDRINVYGMVPpdFCRDPNHLSVPYHYYEPL 284
Cdd:cd23988  204 --STGLLMYTLATRFCDEIHLYGFWP--FPKDANGNPVKYHYYDDL 245
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 97-287 2.54e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 83.34  E-value: 2.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  97 PLKMHCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAP-TRGYGKDVGNKTSLrVIAHSSI-----QRILRNRNELL- 169
Cdd:cd23989   58 PLQLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQL-VTANPSIidkrfQNLLWSRKSFVe 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 170 NMS-HGAVFIFWgPSSYMRRDGKglvynnlqlmnqilPQLKVYMI-----SRHKMLQFDDLFKRETG---KDRKISNTWL 240
Cdd:cd23989  137 SMKvYGRSYIYM-PAFSMKTGTD--------------PSLRVYYTladvgANQTVLFANPNFLRNVGkfwKSKGVHAKRL 201

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 998707127 241 STGWFTMTIALELCDRINVYGMVPpdFCRDPNHLSVPYHYYEPLGPD 287
Cdd:cd23989  202 STGLFLVSAALGLCEEVTIYGFWP--FSVDLDERTISHHYYDNVLPD 246
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 79-310 9.34e-18

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 81.68  E-value: 9.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  79 LPVGAGLLEGYisvLEHKPLKM---HCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIah 155
Cdd:cd23985   22 FPFNTSEWEGY---LPKKSLREevgPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLI-- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 156 sSIQRILRNRNELLNMS--HGAVFIFWGPSSY--------MRRDGKglVYNNLQLMNQILPQLKVYMISRHKMLQFDDLF 225
Cdd:cd23985   97 -NSQLVTTEKHKFLKDSlyNEGILIVWDPAPYhsdipewyKNPDYN--FFENYKTYRRLNPNQPFYILHPQMQWELWDII 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 226 KRETGKDrkISNTWLSTGWFTMTIALELCDRINVYGMVPP----DFCrdpnhlsvpyHYYEPLGPDECTMyishergrkG 301
Cdd:cd23985  174 QENSPEE--IQPNPPSSGMLGIILMMTLCDQVDVYEFLPSkrktDVC----------HYYQKFFDRACTM---------G 232


                 ....*....
gi 998707127 302 SHHRFITEK 310
Cdd:cd23985  233 AYHPLLYEK 241
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 102-282 8.20e-17

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 77.78  E-value: 8.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 102 CKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQ---RILRNRNELLnmshgaVFI 178
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQfdpGIENDPDTLL------VLV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 179 FWGPSSYM---------RRDGKGLVYNNLQLMNQILPQLKV----YM-ISRHKMLQFddlfkreTGKDRKIsnTWLSTGW 244
Cdd:cd23982   76 PFKPLDFYwlyeilsneKRVRKGFWKQPPRIWDANPKQIRIlnpyYTyVAATKLLQV-------PGQRKKK--QKPTTGL 146

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 998707127 245 FTMTIALELCDRINVYGMVPPDfCRDPNHlsvPYHYYE 282
Cdd:cd23982  147 LAITLALHLCDEVHIAGFGYPD-NGNSNQ---PIHYYN 180
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 101-284 2.92e-15

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 73.62  E-value: 2.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 101 HCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVI----AHSSIQRILRNR----------- 165
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTypegAPKSEQEYDPTSlfvavlfksvd 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 166 -NELLNMSHGAVFIFWGPSSYMRRDGKGLVYNNLQLmnQILPQLKVYMISRhKMLQFDDLFKRETGKDRKISntwlSTGW 244
Cdd:cd23983   81 fAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQF--RILNPLIIKETAL-DILQYPEPQSRLWGWDKNVP----TLGV 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 998707127 245 FTMTIALELCDRINVYGmvppdFCRDPNHLSVPYHYYEPL 284
Cdd:cd23983  154 TAVVLATHLCDEVSLAG-----FGYDLSQPHAPLHYYDSV 188
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 101-326 1.49e-14

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 72.70  E-value: 1.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 101 HCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRiLRNRNELLNMSHGAVFIFW 180
Cdd:cd23966   76 RCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVD-LDPGVHLVLVPFKVLDLQW 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 181 GPSS---------YMRrdgkglVYNNLQLmnqilpqlkvymiSRHKMLQFDDLFKREtgkdrkISNTWL-------STGW 244
Cdd:cd23966  155 LISAlttgeitrtYTP------VKRFIKA-------------DKDKVLVINPAFIKY------VHDNWTehhgrypSTGF 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 245 FTMTIALELCDRINVYGMvppdfcrDPNHLSVPYHYYEPLgpdectmyISHERGRKGSHHRFITEKRVFENWARTFDIHF 324
Cdd:cd23966  210 LALIFALHICDEVSVFGF-------GADSKGNWHHYWEKN--------RSAGAFRKTGVHDADFESDIIKKLAKEGKIRV 274


                 ..
gi 998707127 325 FQ 326
Cdd:cd23966  275 YR 276
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 95-321 2.02e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 72.86  E-value: 2.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  95 HKPLKMHCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRV-IAHSSIQ--RILRNRNeLLNM 171
Cdd:cd23973   76 SPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVhTAHSITSslMILQKRG-FKNI 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 172 SHGA----VFIFWGPssymrRDgkglvYNNLQ--LMNQILPQLKVYmiSRHKMLQFDDLFKRET---------------- 229
Cdd:cd23973  155 PQDKdikyILFPEGP-----RD-----YQWLEalLKNKTIPSGAYY--GRRPRSYFSGDFTEDKylvlhpdflryvknrf 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 230 --GKDRKISNTWL---STGWFTMTIALELCDRINVYGMVPPDFCRDPNhlsvpyHYYEpLGPDECTMYISHErgrkgshh 304
Cdd:cd23973  223 lrSKTLKGKYWAIyrpTTGAFLLLTALHLCDTVSAYGFITEDYRKYPD------HYYD-KKKTKLVFYINHD-------- 287

                        250
                 ....*....|....*..
gi 998707127 305 rFITEKRVfenWARTFD 321
Cdd:cd23973  288 -FRLEKKL---WKRLHD 300
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 102-282 2.58e-14

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 70.93  E-value: 2.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 102 CKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSI-------------------QRIL 162
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIfsdpshydpnttvvlipfkPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 163 RNRNELLNMSHGAVFIFWgpssymRRDGKGLVYNNLQLmnQILPQLKVYmISRHKMLQFDDLFKREtgkDRKISNTwlsT 242
Cdd:cd23984   82 RWLLDLLMGKKVSAKGFW------KKPALNLIYKPNQI--RILNPFILR-IAAYELLHFPKRFPKE---KKPKHPT---T 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 998707127 243 GWFTMTIALELCDRINVYGmvppdFCRDPNHLSVPYHYYE 282
Cdd:cd23984  147 GIIAITLALHICNEVHIAG-----FKYDFSNLNSTLHYYG 181
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 102-282 2.95e-13

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 68.03  E-value: 2.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 102 CKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVI-AHSSIQRILRNRNEllnmshgAVFIFW 180
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITyPEGAIQKPEQYEKD-------SLFVLA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 181 GpssYMRRDGKGLVY----NNLQLMNQILPQLKVYMISR-HKMLQFDDLFKRETGKD---RKISNTWL------STGWFT 246
Cdd:cd23981   75 G---FKWQDFKWLKYivykEKVSASDGFWKSVATRVPREpHEIRILNPYFIQEAAFSfigLPFNNGLMgrgnipTLGSVA 151

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 998707127 247 MTIALELCDRINVYGmvppdFCRDPNHLSVPYHYYE 282
Cdd:cd23981  152 ITMALHNCDEVAVAG-----FGYDMNTPNAPLHYYE 182
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 103-286 3.95e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 68.63  E-value: 3.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 103 KSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRG-YGKDVGNKTSLrVIAHSSI-----QRILRNRNELLN--MSHG 174
Cdd:cd23991   65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL-VTANPSIisikyAKLNERRKPFLEtvSVYG 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 175 AVFIFWGPSSYmrRDGKGLVYNNLQLMNQILPQLKVymISRH-KMLQFDDLFKRETGkdrkISNTWLSTGWFTMTIALEL 253
Cdd:cd23991  144 DAFLLLPAFSY--RSNTALSFKVYYTLEDFKAKQKV--IFFHpIYLKHLAQFWRSKG----VQVYRLSTGLMITSAALEL 215

                        170       180       190
                 ....*....|....*....|....*....|...
gi 998707127 254 CDRINVYGMVPpdFCRDPNHLSVPYHYYEPLGP 286
Cdd:cd23991  216 CEEVKLYGFWP--FSKNTEGKPISHHYYDNQLP 246
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 89-282 4.51e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 68.82  E-value: 4.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  89 YISVLEHKPLKmhCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVI-AHSSIQRILRNrne 167
Cdd:cd23964   71 YMFVLRGGRPR--CIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFfPESLHNSLLKH--- 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 168 lLNMSHGAVFIFwgpSSYMRRDgkgLVYNNLQLMNQILPQLKVYMISRHKMLQFD-----------DLFkretgkdRKIS 236
Cdd:cd23964  146 -VPQDKDTKYLF---IPFKIRD---YDYLDAVLSGKPVPDGCDKGKRPPPLFGPKlnatnvrllhpDFI-------RYLF 211

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 998707127 237 NTWL--------STGWFTMTIALELCDRINVYGmvppdFCRDPNHlsvPYHYYE 282
Cdd:cd23964  212 NRWLnsstsyrpTTGALMLLTALHTCDQVSVYG-----FGYDPRF---SLHYYD 257
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 84-261 3.46e-10

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 59.89  E-value: 3.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127  84 GLLEGYISVLEHKPLkMHCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILR 163
Cdd:cd23980   64 QVVPGNVDPLLEKRL-VSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQ 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 164 NRNELL------------------NMSHGAVFIfwgPSSYMRRDGKGLVYNnlqlmnqilPQLKVYMISRhkMLQfddlf 225
Cdd:cd23980  143 NVSMILvpfktldlewvisatttgTISHTYVPV---PRKIKVKKEKILIYH---------PAFIKYVFDR--WLQ----- 203

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 998707127 226 kretGKDRkisntWLSTGWFTMTIALELCDRINVYG 261
Cdd:cd23980  204 ----GHGR-----YPSTGILSVIFSLHVCDEVDLYG 230
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 101-261 4.88e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 59.50  E-value: 4.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 101 HCKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELL----------- 169
Cdd:cd23979   79 RCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLvpfktldllwi 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 170 --NMSHGAVFIFWGP-SSYMRRDG-KGLVYNnlqlmnqilPQLKVYMisrhkmlqfDDLFKRETGKdrkisntWLSTGWF 245
Cdd:cd23979  159 tsALSTGQIRFTYAPvKQFLRVDKdKVQIYN---------PAFFKYI---------HDRWTEHHGR-------YPSTGML 213

                        170
                 ....*....|....*.
gi 998707127 246 TMTIALELCDRINVYG 261
Cdd:cd23979  214 VLFFALHVCDEVNVYG 229
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 102-149 1.91e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 51.75  E-value: 1.91e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 998707127 102 CKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTS 149
Cdd:cd23972   82 CIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTS 129
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 102-164 2.57e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 48.60  E-value: 2.57e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 998707127 102 CKSCALVTSSGHLLGSSQGDRIDESECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRN 164
Cdd:cd23974   84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRA 146
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 103-286 3.66e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 47.91  E-value: 3.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 103 KSCALVTSSGHLLGSSQGDRIDESECVIRMNDAP-TRGYGKDVGNKTSLRVIAHSSI----QRILRNRN---ELLNMSHG 174
Cdd:cd23990   65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPSIIterfHKLEKWRRpfyEVLQVYEN 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998707127 175 AVFIFwgPSSYMRRDgKGLVYNNLQLMNQILPQLKVYMISRHKMLQFDDLFKRETGKDRKISntwlsTGWFTMTIALELC 254
Cdd:cd23990  145 ASVVL--PAFYNTRN-TDVSIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRIS-----SGLMLVTAALELC 216

                        170       180       190
                 ....*....|....*....|....*....|..
gi 998707127 255 DRINVYGMVPpdFCRDPNHLSVPYHYYEPLGP 286
Cdd:cd23990  217 EEVHLYGFWA--FPMNPSGIFITHHYYDNVKP 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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