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Conserved domains on  [gi|1387196369|ref|XP_015328695|]
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solute carrier family 12 member 1 isoform X1 [Bos taurus]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
104-1131 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1489.59  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  104 NTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNVSVAPGSADVVANGEGTPGDEQAEN----KGEDQAGAVKFGW 179
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  180 VKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTmvtsitglstsaiatngfvrgglgviiiglsvVVTTLTG 259
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCC--------------------------------CVTTITG 128
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  260 ISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKETDS-MMVDPTNDIRIIGS 338
Cdd:TIGR00930  129 LSMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGT 208
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  339 ITVVILLGISVAGMEWEAKAQVILLIILLIAIANFFIGTVIPSNNeKRARGFFNYQASIFAENFGPSFTKGEG-FFSVFA 417
Cdd:TIGR00930  209 VTVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFG 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  418 IFFPAATGILAGANISGDLEDPQDAIPKGTMLAIFITTVAYLGVAICVGACVVRDATGSVNDTIISgmnCNGSAACglgy 497
Cdd:TIGR00930  288 IFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC---- 360
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  498 dFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPL 577
Cdd:TIGR00930  361 -FSECAHNTCSYGLMNNLQVMSLVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPL 439
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  578 RGYFLTFVIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINW 657
Cdd:TIGR00930  440 RAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISW 519
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  658 WAAVITYVIEFFLYIYVTYKKPDVNWGSSTQALSYMSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFT 737
Cdd:TIGR00930  520 WAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFT 599
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  738 KNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNW 817
Cdd:TIGR00930  600 KGKGLMICGSVIQGPRLECVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDW 679
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  818 RKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISqVLQVqeelekleqerlaleatiKDNESEEGNggirglfkkag 897
Cdd:TIGR00930  680 RQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEGLPIS-VLQV------------------QEELENDCS----------- 729
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  898 klniTKPTPKKDSSINTIQSMHvgefnqklVEASTQFKKKQGKGTIDVWWLFDDGGLILLIPYILTLRKKWKDCKLRIYV 977
Cdd:TIGR00930  730 ----EDSIELNDGKISTQPDMH--------LEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFV 797
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  978 GG-KINRIEEEKIAMASLLSKFRIKFADIHVIGDINVKPNKESWKVFEEMIEPYCLHESCKDLTTAE-KLKRETPWKITD 1055
Cdd:TIGR00930  798 GAqKDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITD 877
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387196369 1056 AELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDWLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1131
Cdd:TIGR00930  878 AELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
104-1131 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1489.59  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  104 NTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNVSVAPGSADVVANGEGTPGDEQAEN----KGEDQAGAVKFGW 179
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  180 VKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTmvtsitglstsaiatngfvrgglgviiiglsvVVTTLTG 259
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCC--------------------------------CVTTITG 128
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  260 ISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKETDS-MMVDPTNDIRIIGS 338
Cdd:TIGR00930  129 LSMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGT 208
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  339 ITVVILLGISVAGMEWEAKAQVILLIILLIAIANFFIGTVIPSNNeKRARGFFNYQASIFAENFGPSFTKGEG-FFSVFA 417
Cdd:TIGR00930  209 VTVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFG 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  418 IFFPAATGILAGANISGDLEDPQDAIPKGTMLAIFITTVAYLGVAICVGACVVRDATGSVNDTIISgmnCNGSAACglgy 497
Cdd:TIGR00930  288 IFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC---- 360
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  498 dFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPL 577
Cdd:TIGR00930  361 -FSECAHNTCSYGLMNNLQVMSLVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPL 439
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  578 RGYFLTFVIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINW 657
Cdd:TIGR00930  440 RAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISW 519
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  658 WAAVITYVIEFFLYIYVTYKKPDVNWGSSTQALSYMSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFT 737
Cdd:TIGR00930  520 WAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFT 599
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  738 KNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNW 817
Cdd:TIGR00930  600 KGKGLMICGSVIQGPRLECVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDW 679
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  818 RKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISqVLQVqeelekleqerlaleatiKDNESEEGNggirglfkkag 897
Cdd:TIGR00930  680 RQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEGLPIS-VLQV------------------QEELENDCS----------- 729
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  898 klniTKPTPKKDSSINTIQSMHvgefnqklVEASTQFKKKQGKGTIDVWWLFDDGGLILLIPYILTLRKKWKDCKLRIYV 977
Cdd:TIGR00930  730 ----EDSIELNDGKISTQPDMH--------LEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFV 797
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  978 GG-KINRIEEEKIAMASLLSKFRIKFADIHVIGDINVKPNKESWKVFEEMIEPYCLHESCKDLTTAE-KLKRETPWKITD 1055
Cdd:TIGR00930  798 GAqKDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITD 877
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387196369 1056 AELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDWLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1131
Cdd:TIGR00930  878 AELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
726-1131 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 599.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  726 RPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNsgMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMK 805
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  806 PNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQ-VQEELEKLEQERLALEATIKDNESEE 884
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQdQDTEELGLGDETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  885 GNGGIRGLFKKAGKLNITKPTPKKDSsiNTIQSMHVGEFNQKLV------------------EASTQFKKKQGKGTIDVW 946
Cdd:pfam03522  159 SNSKQDDDKSKLSKKDSNLSLSPDKS--TKNPSGKDSSKSDKLKkkspsiilrtasnekeilNNITQFQKKQKKGTIDVW 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  947 WLFDDGGLILLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKIAMASLLSKFRIKFADIHVIGDINVKPNKESWKVFEE 1025
Cdd:pfam03522  237 WLYDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDE 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369 1026 MIEPYCLHESCKDLttaeklkrETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDWLYMAW 1105
Cdd:pfam03522  317 LIEPFRLHEDDKEE--------ESAEKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAW 388
                          410       420
                   ....*....|....*....|....*.
gi 1387196369 1106 LEILTKNLPPVLLVRGNHKNVLTFYS 1131
Cdd:pfam03522  389 LETLTKDLPPFLLVRGNQTSVLTFYS 414
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
211-681 3.99e-36

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 142.73  E-value: 3.99e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  211 LGVLIILLSTMVTSITGLSTSAIATNGfvrGGLGVIIIGLSVVVTTLTGISMSAICTNgVVRGGGAYYLISRSLGPEFGG 290
Cdd:COG0531     16 FDLVALGVGAIIGAGIFVLPGLAAGLA---GPAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGF 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  291 SIGLIFAFANAVAVAMYVVGFAETVVDLLketdsmmvdPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLIAI 370
Cdd:COG0531     92 LAGWALLLSYVLAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVL 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  371 ANFFIGtvipsnnekrarGFFNYQASIFAeNFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPKGTMLA 450
Cdd:COG0531    163 LLFIVV------------GLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILS 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  451 IFITTVAYLGVAICVGACVVRDATGSVNDTIisgmncngsaacglgydfsrcrhepcqyglmnnFQVMSMVSG--FGPLI 528
Cdd:COG0531    230 LLIVGVLYILVSLALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILI 276
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  529 TAGIFSATLSSALASLVSAPKVFQALCKDNIykALQFFAKGYGKNNEPLRGYFLTFVIAMAFILI--AELNTIAPIISNF 606
Cdd:COG0531    277 ALGALLSLLGALNASILGASRLLYAMARDGL--LPKVFAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVG 354
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1387196369  607 FLASYALINFSCFHASYaKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWA---AVITYVIEFFLYIYVTYKKPDV 681
Cdd:COG0531    355 VLLAYLLVALAVIVLRR-RRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGAlliGLVLLAIGLLLYLLYRRRHPKL 431
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
104-1131 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1489.59  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  104 NTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNVSVAPGSADVVANGEGTPGDEQAEN----KGEDQAGAVKFGW 179
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  180 VKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTmvtsitglstsaiatngfvrgglgviiiglsvVVTTLTG 259
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCC--------------------------------CVTTITG 128
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  260 ISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKETDS-MMVDPTNDIRIIGS 338
Cdd:TIGR00930  129 LSMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGT 208
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  339 ITVVILLGISVAGMEWEAKAQVILLIILLIAIANFFIGTVIPSNNeKRARGFFNYQASIFAENFGPSFTKGEG-FFSVFA 417
Cdd:TIGR00930  209 VTVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFG 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  418 IFFPAATGILAGANISGDLEDPQDAIPKGTMLAIFITTVAYLGVAICVGACVVRDATGSVNDTIISgmnCNGSAACglgy 497
Cdd:TIGR00930  288 IFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC---- 360
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  498 dFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPL 577
Cdd:TIGR00930  361 -FSECAHNTCSYGLMNNLQVMSLVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPL 439
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  578 RGYFLTFVIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINW 657
Cdd:TIGR00930  440 RAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISW 519
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  658 WAAVITYVIEFFLYIYVTYKKPDVNWGSSTQALSYMSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFT 737
Cdd:TIGR00930  520 WAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFT 599
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  738 KNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNW 817
Cdd:TIGR00930  600 KGKGLMICGSVIQGPRLECVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDW 679
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  818 RKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISqVLQVqeelekleqerlaleatiKDNESEEGNggirglfkkag 897
Cdd:TIGR00930  680 RQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEGLPIS-VLQV------------------QEELENDCS----------- 729
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  898 klniTKPTPKKDSSINTIQSMHvgefnqklVEASTQFKKKQGKGTIDVWWLFDDGGLILLIPYILTLRKKWKDCKLRIYV 977
Cdd:TIGR00930  730 ----EDSIELNDGKISTQPDMH--------LEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFV 797
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  978 GG-KINRIEEEKIAMASLLSKFRIKFADIHVIGDINVKPNKESWKVFEEMIEPYCLHESCKDLTTAE-KLKRETPWKITD 1055
Cdd:TIGR00930  798 GAqKDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITD 877
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387196369 1056 AELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDWLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1131
Cdd:TIGR00930  878 AELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
726-1131 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 599.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  726 RPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNsgMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMK 805
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  806 PNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQ-VQEELEKLEQERLALEATIKDNESEE 884
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQdQDTEELGLGDETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  885 GNGGIRGLFKKAGKLNITKPTPKKDSsiNTIQSMHVGEFNQKLV------------------EASTQFKKKQGKGTIDVW 946
Cdd:pfam03522  159 SNSKQDDDKSKLSKKDSNLSLSPDKS--TKNPSGKDSSKSDKLKkkspsiilrtasnekeilNNITQFQKKQKKGTIDVW 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  947 WLFDDGGLILLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKIAMASLLSKFRIKFADIHVIGDINVKPNKESWKVFEE 1025
Cdd:pfam03522  237 WLYDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDE 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369 1026 MIEPYCLHESCKDLttaeklkrETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDWLYMAW 1105
Cdd:pfam03522  317 LIEPFRLHEDDKEE--------ESAEKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAW 388
                          410       420
                   ....*....|....*....|....*.
gi 1387196369 1106 LEILTKNLPPVLLVRGNHKNVLTFYS 1131
Cdd:pfam03522  389 LETLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease pfam00324
Amino acid permease;
182-717 3.97e-119

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 375.89  E-value: 3.97e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  182 GVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVrgglgviiiglsvvvttltgis 261
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV---------------------- 58
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  262 msaictngvvrGGGAYYLISRSLGPEFGGSIGL------IFAFANAVAVAMYVVGFAETVVDLLKetdsmmvdptndIRI 335
Cdd:pfam00324   59 -----------SGGFYTYASRFLGPSLGFATGWnywlswITVLALELTAASILIQFWELVPDIPY------------LWV 115
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  336 IGSITVVILLGISVAGMEWEAKAQVILLIILLIAIANFFIGTVIPSNNEKRARG--FFNYQASIFAENFGPSFTKGegFF 413
Cdd:pfam00324  116 WGAVFLVLLTIINLVGVKWYGEAEFWFALIKIIAIIGFIIVGIILLSGGNPNDGaiFRYLGDNGGKNNFPPGFGKG--FI 193
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  414 SVFAIFFPAATGILAGANISGDLEDPQDAIPKGTMLAIFITTVAYLGVAICVGACVVRDATGSVNDTIISgmncngsaac 493
Cdd:pfam00324  194 SVFVIAFFAFTGIELVGIAAGEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASA---------- 263
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  494 glgydfsrcrhepcqYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKalqFFAKGYGKN 573
Cdd:pfam00324  264 ---------------ASPFVIFFKFLGISGLAPLINAVILTAALSAANSSLYSGSRMLYSLARDGLAP---KFLKKVDKR 325
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  574 NEPLRGYFLTFVIAMAFILIAELNTIapIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMF 653
Cdd:pfam00324  326 GVPLRAILVSMVISLLALLLASLNPA--IVFNFLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLG 403
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1387196369  654 VINWWAAVITYVIEFFLYIYVTYKKPDVNWGSSTQALSYMSALDNALELTTVEDHVKNFRPQCI 717
Cdd:pfam00324  404 VILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
211-681 3.99e-36

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 142.73  E-value: 3.99e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  211 LGVLIILLSTMVTSITGLSTSAIATNGfvrGGLGVIIIGLSVVVTTLTGISMSAICTNgVVRGGGAYYLISRSLGPEFGG 290
Cdd:COG0531     16 FDLVALGVGAIIGAGIFVLPGLAAGLA---GPAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGF 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  291 SIGLIFAFANAVAVAMYVVGFAETVVDLLketdsmmvdPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLIAI 370
Cdd:COG0531     92 LAGWALLLSYVLAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVL 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  371 ANFFIGtvipsnnekrarGFFNYQASIFAeNFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPKGTMLA 450
Cdd:COG0531    163 LLFIVV------------GLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILS 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  451 IFITTVAYLGVAICVGACVVRDATGSVNDTIisgmncngsaacglgydfsrcrhepcqyglmnnFQVMSMVSG--FGPLI 528
Cdd:COG0531    230 LLIVGVLYILVSLALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILI 276
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  529 TAGIFSATLSSALASLVSAPKVFQALCKDNIykALQFFAKGYGKNNEPLRGYFLTFVIAMAFILI--AELNTIAPIISNF 606
Cdd:COG0531    277 ALGALLSLLGALNASILGASRLLYAMARDGL--LPKVFAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVG 354
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1387196369  607 FLASYALINFSCFHASYaKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWA---AVITYVIEFFLYIYVTYKKPDV 681
Cdd:COG0531    355 VLLAYLLVALAVIVLRR-RRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGAlliGLVLLAIGLLLYLLYRRRHPKL 431
AA_permease_N pfam08403
Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid ...
90-157 2.40e-34

Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid permease domain (pfam00324) in metazoan Na-K-Cl cotransporters.


Pssm-ID: 429977  Cd Length: 70  Bit Score: 125.63  E-value: 2.40e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369   90 DSHTNTYYLQTFGHNTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNV--SVAPGSADVVANGEG 157
Cdd:pfam08403    1 DTHGSTYYLQTFGHNTLDAVPRIDFYRNTGSVSGVKKSRPSLAELHSQLKKNSalAVAEGSVDGVENGDG 70
AA_permease_2 pfam13520
Amino acid permease;
214-676 8.09e-15

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 78.12  E-value: 8.09e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  214 LIILLSTMVTSITGLSTSAIATNGFVRGGLGVIIIGLSVVVTTLTGISMSAICTngvvRGGGAYYLISRSLGPEFGGSIG 293
Cdd:pfam13520    6 AFALVIGSVIGSGIFVAPLVASGGPALIVWGWIAAIIFSLAVGLVYAELSSALP----RSGGIYVYLENAFGKFVAFLAG 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  294 LIFAFANAVAVAMYVVGFAETVVDLLKETdsmMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLIAIANF 373
Cdd:pfam13520   82 WSNWFAYVLGLASSASVAASYLLSALGPD---LVPTTWLTYGIAIAILIIFAIINIRGVRESAKIQNILGILKLLLPLIL 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  374 FIGTVIPsnneKRARGFFNYqASIFAENFGPSFTKGegFFSVFAIFFPAATGILAGANISGdlEDPQDAIPKGTMLAIFI 453
Cdd:pfam13520  159 IIILGLV----TADGGGFNL-LSGEWHTFFPDGWPG--VFAGFLGVLWSFTGFESAANVSE--EVKKRNVPKAIFIGVII 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  454 TTVAYLGVAICVGACVVRDATGSVNDTIISGmncngsaacglgydfsrcrhepcqyGLMNNFQVMSMVSGFgplITAGIF 533
Cdd:pfam13520  230 VGVLYILVNIAFFGVVPDDEIALSSGLGQVA-------------------------ALLFQAVGGKWGAII---VVILLA 281
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196369  534 SATLSSALASLVSAPKVFQALCKDNIYKALQFFAKgYGKNNEPLRGYFLTFVIAMAFILI-----AELNTIAPIISNFFL 608
Cdd:pfam13520  282 LSLLGAVNTAIVGASRLLYALARDGVLPFSRFFAK-VNKFGSPIRAIILTAILSLILLLLfllspAAYNALLSLSAYGYL 360
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1387196369  609 ASYALINFSCFHASYAKSPGWRpaygIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYIYVTY 676
Cdd:pfam13520  361 LSYLLPIIGLLILRKKRPDLGR----IPGRWPVAIFGILFSLFLIVALFFPPVGPATGSSLNYAIILI 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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