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Conserved domains on  [gi|2024358846|ref|XP_015150383|]
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LOW QUALITY PROTEIN: GAS2-like protein 1 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 17-156 4.27e-90

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409117  Cd Length: 142  Bit Score: 278.05  E-value: 4.27e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  17 PFRSSEEYLDAMKEDLAEWFNALYDLDMAADTFLEALATGCDLCQHANNVNRVAMEFQQRHPEAAA--RVPRNEVVFQAR 94
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFFEKLETGVLLCKHANNVTRAAREFQAQHPERASplKLPPREVIFYRP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024358846  95 NVAPGSFVARDNVSNFIRWCRQDLGIQDVLMFETNDLVLKKNEKNVVLCLLEVARRGSKFGM 156
Cdd:cd21268    81 SAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 211-279 5.95e-41

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


:

Pssm-ID: 460480  Cd Length: 69  Bit Score: 143.51  E-value: 5.95e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024358846 211 LDELVREILGCCTCPSQFPMVKISEGKYKVGDSNALIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC 279
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 288-698 1.66e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 1.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  288 PARTLTFSPPKPAVNSASPAPH-APSPSTP------RRADTTSLGDK-RLPGwgdvgysrTERGSTPKPAPGAVLPPRAP 359
Cdd:PHA03247  2551 PPPPLPPAAPPAAPDRSVPPPRpAPRPSEPavtsraRRPDAPPQSARpRAPV--------DDRGDPRGPAPPSPLPPDTH 2622

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  360 ASPSRSPASALRPRDSTRTRRHSGDSDSSSASSVGPPRGHRPPPASCPSPRRPPPGRSRSGDRSPLPmRTATPGGGEERG 439
Cdd:PHA03247  2623 APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR-PTVGSLTSLADP 2701

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  440 RPRVPNGPGLPRARSQGRPGADAVLLIRRGADGQHSWARADGGPRAATRPSGPRRSSLPGDGAEDGDGDAFQEELEELAR 519
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  520 RLRAPLCLEPGQEQQLLGRLEEEFLANTRLMEMGDAEPsPPARPAhGTLEPNSGAAADSAYCSSSSSSSSLNVLGNKHGG 599
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP-PAASPA-GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPG 2859

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  600 PPEDGRRNGGPPAA-----PHPQERR-GRPS-SSSDESGCVPASGAESDPEWAPAVEEEGMETAAVPGIPAsPALRPRAR 672
Cdd:PHA03247  2860 GDVRRRPPSRSPAAkpaapARPPVRRlARPAvSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ-PPPPPPPR 2938

                          410       420
                   ....*....|....*....|....*.
gi 2024358846  673 PRLDAQPGRKPTRIPAPRPPAgPQPW 698
Cdd:PHA03247  2939 PQPPLAPTTDPAGAGEPSGAV-PQPW 2963
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 17-156 4.27e-90

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 278.05  E-value: 4.27e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  17 PFRSSEEYLDAMKEDLAEWFNALYDLDMAADTFLEALATGCDLCQHANNVNRVAMEFQQRHPEAAA--RVPRNEVVFQAR 94
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFFEKLETGVLLCKHANNVTRAAREFQAQHPERASplKLPPREVIFYRP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024358846  95 NVAPGSFVARDNVSNFIRWCRQDLGIQDVLMFETNDLVLKKNEKNVVLCLLEVARRGSKFGM 156
Cdd:cd21268    81 SAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 211-279 5.95e-41

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 143.51  E-value: 5.95e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024358846 211 LDELVREILGCCTCPSQFPMVKISEGKYKVGDSNALIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC 279
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 209-281 1.36e-37

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 134.50  E-value: 1.36e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024358846  209 RNLDELVREILGCCTCPSQFPMVKISEGKYKVGDSNALIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSS 281
Cdd:smart00243   1 DKIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 26-153 2.69e-07

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 49.59  E-value: 2.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  26 DAMKEDLAEWFN---ALYDLDMAADTFLEALATGCDLCQHANNVNrvamefqqrhPEAaarvprnevvFQARNVAPGSFV 102
Cdd:pfam00307   1 LELEKELLRWINshlAEYGPGVRVTNFTTDLRDGLALCALLNKLA----------PGL----------VDKKKLNKSEFD 60

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2024358846 103 ARDNVSNFIRWCRQDLGIQDVLMfETNDLVlKKNEKNVVLCLLEVARRGSK 153
Cdd:pfam00307  61 KLENINLALDVAEKKLGVPKVLI-EPEDLV-EGDNKSVLTYLASLFRRFQA 109
PHA03247 PHA03247
large tegument protein UL36; Provisional
 288-698 1.66e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 1.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  288 PARTLTFSPPKPAVNSASPAPH-APSPSTP------RRADTTSLGDK-RLPGwgdvgysrTERGSTPKPAPGAVLPPRAP 359
Cdd:PHA03247  2551 PPPPLPPAAPPAAPDRSVPPPRpAPRPSEPavtsraRRPDAPPQSARpRAPV--------DDRGDPRGPAPPSPLPPDTH 2622

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  360 ASPSRSPASALRPRDSTRTRRHSGDSDSSSASSVGPPRGHRPPPASCPSPRRPPPGRSRSGDRSPLPmRTATPGGGEERG 439
Cdd:PHA03247  2623 APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR-PTVGSLTSLADP 2701

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  440 RPRVPNGPGLPRARSQGRPGADAVLLIRRGADGQHSWARADGGPRAATRPSGPRRSSLPGDGAEDGDGDAFQEELEELAR 519
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  520 RLRAPLCLEPGQEQQLLGRLEEEFLANTRLMEMGDAEPsPPARPAhGTLEPNSGAAADSAYCSSSSSSSSLNVLGNKHGG 599
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP-PAASPA-GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPG 2859

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  600 PPEDGRRNGGPPAA-----PHPQERR-GRPS-SSSDESGCVPASGAESDPEWAPAVEEEGMETAAVPGIPAsPALRPRAR 672
Cdd:PHA03247  2860 GDVRRRPPSRSPAAkpaapARPPVRRlARPAvSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ-PPPPPPPR 2938

                          410       420
                   ....*....|....*....|....*.
gi 2024358846  673 PRLDAQPGRKPTRIPAPRPPAgPQPW 698
Cdd:PHA03247  2939 PQPPLAPTTDPAGAGEPSGAV-PQPW 2963
SCP1 COG5199
Calponin [Cytoskeleton];
101-161 1.26e-05

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 46.45  E-value: 1.26e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024358846 101 FVARDNVSNFIRWCRQdLGIQDVLMFETNDLVLKKNEKNVVLCLLEVARRGSK-----FGMLAPML 161
Cdd:COG5199    67 FVQMENISSFINGLKK-LRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQKermfsGPFLGPHL 131
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 30-144 3.44e-03

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 37.68  E-value: 3.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846   30 EDLAEWFNALY--DLDMAADTFLEALATGCDLCQHANNVnrvamefqqrhpeaaarVPRnevVFQARNVAPGS--FVARD 105
Cdd:smart00033   1 KTLLRWVNSLLaeYDKPPVTNFSSDLKDGVALCALLNSL-----------------SPG---LVDKKKVAASLsrFKKIE 60

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2024358846  106 NVSNFIRWCRQDLGiqDVLMFETNDLVL-KKNEKNVVLCL 144
Cdd:smart00033  61 NINLALSFAEKLGG--KVVLFEPEDLVEgPKLILGVIWTL 98
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 17-156 4.27e-90

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 278.05  E-value: 4.27e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  17 PFRSSEEYLDAMKEDLAEWFNALYDLDMAADTFLEALATGCDLCQHANNVNRVAMEFQQRHPEAAA--RVPRNEVVFQAR 94
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFFEKLETGVLLCKHANNVTRAAREFQAQHPERASplKLPPREVIFYRP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024358846  95 NVAPGSFVARDNVSNFIRWCRQDLGIQDVLMFETNDLVLKKNEKNVVLCLLEVARRGSKFGM 156
Cdd:cd21268    81 SAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 22-155 4.52e-46

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 160.13  E-value: 4.52e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  22 EEYLDAMKEDLAEWFNALYDLDMAADTFLEALATGCDLCQHANNVNRVAMEFQQRHPEAAARVPRneVVFQARNVAPGSF 101
Cdd:cd21204     1 EEALLPMKEDLAEWLNDLLGDDLTPDNFLDELRNGVVLCQLAQKIQEAAEKAREAGKKNGPPPSY--KLKCNENAKPGSF 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2024358846 102 VARDNVSNFIRWCRqDLGIQDVLMFETNDLVLKKNEKNVVLCLLEVARRGSKFG 155
Cdd:cd21204    79 FARDNVANFLRWCR-KLGVDEVLLFESEDLVLHKNPRQVLLCLLELARIAARYG 131
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 211-279 5.95e-41

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 143.51  E-value: 5.95e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024358846 211 LDELVREILGCCTCPSQFPMVKISEGKYKVGDSNALIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC 279
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 209-281 1.36e-37

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 134.50  E-value: 1.36e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024358846  209 RNLDELVREILGCCTCPSQFPMVKISEGKYKVGDSNALIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSS 281
Cdd:smart00243   1 DKIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 22-156 5.84e-26

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 103.87  E-value: 5.84e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  22 EEYLDAMKEDLAEWFNALYDLDMAADTFLEALATGCDLCQHANNVNRvamEFQQRHPEA---AARVPRNEVVFQArNVAP 98
Cdd:cd21267     2 EASLLPMKEDLALWLTNLLGKEITAESFMEKLDNGALLCQLAETLQE---KFKENSADAnkpGKSLPVRKIPCRA-NAPS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024358846  99 GSFVARDNVSNFIRWCRqDLGIQDVLMFETNDLVLKKNEKNVVLCLLEVARRGSKFGM 156
Cdd:cd21267    78 GSFFARDNTANFLSWCR-DVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGV 134
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 22-155 9.87e-25

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 99.91  E-value: 9.87e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  22 EEYLDAMKEDLAEWFNALYDLDMAADTFLEALATGCDLCQHANNVNRVAMEfqQRHPEAAARVPRNEVVFQaRNVAPGSF 101
Cdd:cd21269     1 EATLVPMQEDLSIWLSGMLGKEVKAERFMEELDNGVLLCQLIGVLQSKIKE--CCSTEELKHFPMRKVPCK-KDAPSGSF 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2024358846 102 VARDNVSNFIRWCRqDLGIQDVLMFETNDLVLKKNEKNVVLCLLEVARRGSKFG 155
Cdd:cd21269    78 FARDNTANFLSWCR-AIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 29-149 2.88e-10

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 57.73  E-value: 2.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  29 KEDLAEWFNAL--YDLDMAADTFLEALATGCDLCQHANNVnrvamefqqrHPEAAARVPRNevvfqarnvAPGSFVARDN 106
Cdd:cd00014     1 EEELLKWINEVlgEELPVSITDLFESLRDGVLLCKLINKL----------SPGSIPKINKK---------PKSPFKKREN 61

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2024358846 107 VSNFIRWCRqDLGIQDVLMFETNDLVLKKNEKNVVLCLLEVAR 149
Cdd:cd00014    62 INLFLNACK-KLGLPELDLFEPEDLYEKGNLKKVLGTLWALAL 103
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 48-149 9.85e-09

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 53.14  E-value: 9.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  48 TFLEALATGCDLCQHANNVnrvamefqqrHPEAAARVprnevvfqarNVAPGSFVARDNVSNFIRWCRQdLGIQDVLMFE 127
Cdd:cd21210    21 DLLDALKDGVVLCKLANRI----------LPADIRKY----------KESKMPFVQMENISAFLNAARK-LGVPENDLFQ 79

                          90       100
                  ....*....|....*....|..
gi 2024358846 128 TNDLVLKKNEKNVVLCLLEVAR 149
Cdd:cd21210    80 TVDLFERKNPAQVLQCLHALSR 101
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 26-153 2.69e-07

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 49.59  E-value: 2.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  26 DAMKEDLAEWFN---ALYDLDMAADTFLEALATGCDLCQHANNVNrvamefqqrhPEAaarvprnevvFQARNVAPGSFV 102
Cdd:pfam00307   1 LELEKELLRWINshlAEYGPGVRVTNFTTDLRDGLALCALLNKLA----------PGL----------VDKKKLNKSEFD 60

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2024358846 103 ARDNVSNFIRWCRQDLGIQDVLMfETNDLVlKKNEKNVVLCLLEVARRGSK 153
Cdd:pfam00307  61 KLENINLALDVAEKKLGVPKVLI-EPEDLV-EGDNKSVLTYLASLFRRFQA 109
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 23-144 1.07e-06

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 47.99  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  23 EYLDAMKEDLaEWFNALYDLDM-AADTFLEALATGCDLCQHANNVNrvamefqqrhPEAAARVPRNEVVFQARNVapgsf 101
Cdd:cd21206     5 EYLCRLEEAK-QWIEACLNEELpPTTEFEEELRNGVVLAKLANKFA----------PKLVPLKKIYDVGLQFRHT----- 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2024358846 102 varDNVSNFIRWCRqDLGIQDVLMFETNDLVLKKNEKNVVLCL 144
Cdd:cd21206    69 ---DNINHFLRALK-KIGLPKIFHFETTDLYEKKNIPKVIYCL 107
PHA03247 PHA03247
large tegument protein UL36; Provisional
 288-698 1.66e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 1.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  288 PARTLTFSPPKPAVNSASPAPH-APSPSTP------RRADTTSLGDK-RLPGwgdvgysrTERGSTPKPAPGAVLPPRAP 359
Cdd:PHA03247  2551 PPPPLPPAAPPAAPDRSVPPPRpAPRPSEPavtsraRRPDAPPQSARpRAPV--------DDRGDPRGPAPPSPLPPDTH 2622

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  360 ASPSRSPASALRPRDSTRTRRHSGDSDSSSASSVGPPRGHRPPPASCPSPRRPPPGRSRSGDRSPLPmRTATPGGGEERG 439
Cdd:PHA03247  2623 APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR-PTVGSLTSLADP 2701

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  440 RPRVPNGPGLPRARSQGRPGADAVLLIRRGADGQHSWARADGGPRAATRPSGPRRSSLPGDGAEDGDGDAFQEELEELAR 519
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  520 RLRAPLCLEPGQEQQLLGRLEEEFLANTRLMEMGDAEPsPPARPAhGTLEPNSGAAADSAYCSSSSSSSSLNVLGNKHGG 599
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP-PAASPA-GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPG 2859

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  600 PPEDGRRNGGPPAA-----PHPQERR-GRPS-SSSDESGCVPASGAESDPEWAPAVEEEGMETAAVPGIPAsPALRPRAR 672
Cdd:PHA03247  2860 GDVRRRPPSRSPAAkpaapARPPVRRlARPAvSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ-PPPPPPPR 2938

                          410       420
                   ....*....|....*....|....*.
gi 2024358846  673 PRLDAQPGRKPTRIPAPRPPAgPQPW 698
Cdd:PHA03247  2939 PQPPLAPTTDPAGAGEPSGAV-PQPW 2963
SCP1 COG5199
Calponin [Cytoskeleton];
101-161 1.26e-05

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 46.45  E-value: 1.26e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024358846 101 FVARDNVSNFIRWCRQdLGIQDVLMFETNDLVLKKNEKNVVLCLLEVARRGSK-----FGMLAPML 161
Cdd:COG5199    67 FVQMENISSFINGLKK-LRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQKermfsGPFLGPHL 131
PHA03247 PHA03247
large tegument protein UL36; Provisional
 296-727 4.83e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 4.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  296 PPKPAVNSASPAPHAPSPSTPRRAdttslgdkrlpgwgdvgySRTERGSTPKPAPGAVLPPRAPasPSRSPASALRPRDS 375
Cdd:PHA03247  2577 PSEPAVTSRARRPDAPPQSARPRA------------------PVDDRGDPRGPAPPSPLPPDTH--APDPPPPSPSPAAN 2636

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  376 trtrrhsgdsdsssassvgpprghrpppaSCPSPRRPPPGRSRSGDRSPLPMRTATPGGGEERGRPRVPNGPGLPRARSQ 455
Cdd:PHA03247  2637 -----------------------------EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  456 GRPGADAVLlirrgadgqhSWARADGGPRAATRPSGPRRSSLPGDGAEDGDGDAFQEELEELARRLRAPLCLEPGQEQQl 535
Cdd:PHA03247  2688 ARPTVGSLT----------SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPAR- 2756

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  536 lgrleeeflANTRLMEMGDAEPSPPARPAHGTLEPNSGAAADSAYCSSSSSSSSLNVLGNKHGGPPEDGRRN-GGPPAAP 614
Cdd:PHA03247  2757 ---------PARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPpAASPAGP 2827

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  615 HPQERRGRPSSSSDESGCVPAS---GAESDPEWAPAVEEEGMETAAVPGIPASPALRPRARPRLD------AQPGRKPTR 685
Cdd:PHA03247  2828 LPPPTSAQPTAPPPPPGPPPPSlplGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSrstesfALPPDQPER 2907

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|..
gi 2024358846  686 IPAPRPPAGPQPWRALHTVLASLLEPGRAPREDEGLQEDAWP 727
Cdd:PHA03247  2908 PPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP 2949
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 595-719 6.80e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.22  E-value: 6.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846 595 NKHGGPPEDGRRNGGPPAAPhpqerrGRPSSSSDESGcvPASGAESDPEWAPAVEEEGMETAAVPGiPASPAlRPRARPR 674
Cdd:PTZ00449  505 DKHDEPPEGPEASGLPPKAP------GDKEGEEGEHE--DSKESDEPKEGGKPGETKEGEVGKKPG-PAKEH-KPSKIPT 574

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2024358846 675 LDAQP-----GRKPTRIPAPRPPAGP----QPWRALHTVLASLLEPGRAPREDE 719
Cdd:PTZ00449  575 LSKKPefpkdPKHPKDPEEPKKPKRPrsaqRPTRPKSPKLPELLDIPKSPKRPE 628
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 34-149 1.09e-04

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 41.91  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  34 EWFNALYDLDMAADT-FLEALATGCDLCQHANNVNrvamefqqrhPEAAARVprnevvfqarNVAPGSFVARDNVSNFIR 112
Cdd:cd21207    12 DWIEAVTGEKLDDGKdYEDVLKDGVILCKLINILK----------PGSVKKI----------NTSKMAFKLMENIENFLT 71

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2024358846 113 WCRQdLGIQDVLMFETNDLVLKKNEKNVVLCLLEVAR 149
Cdd:cd21207    72 ACKG-YGVPKTDLFQTVDLYEKKNIPQVTNCLFALGR 107
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 287-697 4.00e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 4.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  287 PPARTLTFSPPKPAVNSASPAPHAPSPSTPRRADTTSLGDKRLPGWGDVGYSRTERGSTPKPAPGAVLPPRAPASPSRSP 366
Cdd:PHA03307    54 TVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPD 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  367 AS-ALRPRDSTRTRRHSGDSDSSSASSVGPPRGHRPPPASCPSPRRPPPGRSRSGDRSPLPMRTATPGGgeeRGRPRVPN 445
Cdd:PHA03307   134 LSeMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAA---SPRPPRRS 210

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  446 GP-GLPRARSQGRPGADAVLLIRRGADGQHSW--ARADGGPRAATRPSGPRRSSLPGDGAEDGDGdafqeeleeLARRLR 522
Cdd:PHA03307   211 SPiSASASSPAPAPGRSAADDAGASSSDSSSSesSGCGWGPENECPLPRPAPITLPTRIWEASGW---------NGPSSR 281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  523 APLCLEPGQEQQLLGRLEEeflantrlmEMGDAEPSPPARPAHGTLEPNSGAAADSAYCSSSSSSSSLNVLGNKHGGPPE 602
Cdd:PHA03307   282 PGPASSSSSPRERSPSPSP---------SSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPS 352

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846  603 DGRrnGGPPAAPHPQERRGRPSSSSDESGCVPASGAESDPEWAPAVEEEGMETAAVPGIPASPALRPRARPRLDAQPGRK 682
Cdd:PHA03307   353 PSR--PPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARY 430

                          410
                   ....*....|....*..
gi 2024358846  683 PTRIPA--PRPPAGPQP 697
Cdd:PHA03307   431 PLLTPSgePWPGSPPPP 447
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 565-700 7.72e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 7.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846 565 HGTLEPNSGAAADSAYCSSSSSSSSLNVLGNKHGGPPEDGRRNGGPPAAPHPQERRGRPSSSSDESGCVPASGAESDPEW 644
Cdd:PRK07764  579 GGDWQVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVA 658

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024358846 645 APAVEEEGMETAAVPGIPASPALRPRARPRLDAQPGRKPTRIPAPRPPAGPQPWRA 700
Cdd:PRK07764  659 VPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQA 714
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 30-144 3.44e-03

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 37.68  E-value: 3.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846   30 EDLAEWFNALY--DLDMAADTFLEALATGCDLCQHANNVnrvamefqqrhpeaaarVPRnevVFQARNVAPGS--FVARD 105
Cdd:smart00033   1 KTLLRWVNSLLaeYDKPPVTNFSSDLKDGVALCALLNSL-----------------SPG---LVDKKKVAASLsrFKKIE 60

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2024358846  106 NVSNFIRWCRQDLGiqDVLMFETNDLVL-KKNEKNVVLCL 144
Cdd:smart00033  61 NINLALSFAEKLGG--KVVLFEPEDLVEgPKLILGVIWTL 98
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
555-727 5.27e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 5.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846 555 AEPSPPARPAHGTLEPNSGAAADSAYCSSSSSSSSLNVLGNKHGGPPEDGRRNGGPPAAPHP----------QERRGRP- 623
Cdd:PRK12323  395 AAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAapaaaarpaaAGPRPVAa 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024358846 624 ----SSSSDESGCVPASGAESDPEW-----APAVEEEGMETAAVPGIPASPALRPRARPRLDAQPGRKPTRIPAPRPPAG 694
Cdd:PRK12323  475 aaaaAPARAAPAAAPAPADDDPPPWeelppEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAA 554

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2024358846 695 PQPWRALHTVLASLLEPGRAPREDEGlqedaWP 727
Cdd:PRK12323  555 AATEPVVAPRPPRASASGLPDMFDGD-----WP 582
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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