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Conserved domains on  [gi|968061718|ref|XP_015022077|]
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triosephosphate isomerase isoform X2 [Drosophila mojavensis]

Protein Classification

triose-phosphate isomerase( domain architecture ID 10794370)

triose-phosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate

CATH:  3.20.20.70
EC:  5.3.1.1
Gene Ontology:  GO:0004807|GO:0006096|GO:0031625|GO:0042803
PubMed:  11257493|12206759

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 1-246 5.04e-131

triosephosphate isomerase; Provisional


:

Pssm-ID: 240365  Cd Length: 255  Bit Score: 370.01  E-value: 5.04e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   1 MSGRKFCVGGNWKMNGDQKSIAEICKVLSDAQLDP-NTDVVIGCPAIYLMFARNLLPCS-IGVAGQNAYKVAKGAFTGEI 78
Cdd:PTZ00333   1 MMKRKPFVGGNWKCNGTKASIKELIDSFNKLKFDPnNVDVVVAPPSLHIPLVQEKLKNKnFKISSQNVSLTGSGAFTGEI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  79 SPAMLKDVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQMCAYAKKIRD-- 156
Cdd:PTZ00333  81 SAEMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEEREAGQTSDVLSKQLEAIVKKVSDea 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 157 WTNVVVAYEPVWAIGTGKTATPDQAQEVHAFLRQWLTENISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASL 236
Cdd:PTZ00333 161 WDNIVIAYEPVWAIGTGKVATPEQAQEVHAFIRKWLAEKVGADVAEATRIIYGGSVNEKNCKELIKQPDIDGFLVGGASL 240

                        250
                 ....*....|
gi 968061718 237 KPEFVDIVNA 246
Cdd:PTZ00333 241 KPDFVDIIKS 250
 
Name Accession Description Interval E-value
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 1-246 5.04e-131

triosephosphate isomerase; Provisional


Pssm-ID: 240365  Cd Length: 255  Bit Score: 370.01  E-value: 5.04e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   1 MSGRKFCVGGNWKMNGDQKSIAEICKVLSDAQLDP-NTDVVIGCPAIYLMFARNLLPCS-IGVAGQNAYKVAKGAFTGEI 78
Cdd:PTZ00333   1 MMKRKPFVGGNWKCNGTKASIKELIDSFNKLKFDPnNVDVVVAPPSLHIPLVQEKLKNKnFKISSQNVSLTGSGAFTGEI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  79 SPAMLKDVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQMCAYAKKIRD-- 156
Cdd:PTZ00333  81 SAEMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEEREAGQTSDVLSKQLEAIVKKVSDea 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 157 WTNVVVAYEPVWAIGTGKTATPDQAQEVHAFLRQWLTENISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASL 236
Cdd:PTZ00333 161 WDNIVIAYEPVWAIGTGKVATPEQAQEVHAFIRKWLAEKVGADVAEATRIIYGGSVNEKNCKELIKQPDIDGFLVGGASL 240

                        250
                 ....*....|
gi 968061718 237 KPEFVDIVNA 246
Cdd:PTZ00333 241 KPDFVDIIKS 250
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 6-245 2.15e-128

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 363.01  E-value: 2.15e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   6 FCVGGNWKMNGDQKSIAEICKVLSDAQLDP-NTDVVIGCPAIYLMFARNLLPCS-IGVAGQNAYKVAKGAFTGEISPAML 83
Cdd:cd00311    1 PLVAGNWKMNGTLAEALELAKALNAVLKDEsGVEVVVAPPFTYLAAVAEALEGSkIKVGAQNVSPEDSGAFTGEISAEML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  84 KDVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQMCAYAKKIRDWTNVVVA 163
Cdd:cd00311   81 KDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGVEDLAPVVIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 164 YEPVWAIGTGKTATPDQAQEVHAFLRQWLTENISkEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLKPE-FVD 242
Cdd:cd00311  161 YEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYG-EVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKAEsFLD 239


                 ...
gi 968061718 243 IVN 245
Cdd:cd00311  240 IIK 242
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 4-246 5.48e-125

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 354.75  E-value: 5.48e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   4 RKFCVGGNWKMNGDQKSIAEICKVLSDAQLD-PNTDVVIGCPAIYLMFARNLLPCS-IGVAGQNAYKVAKGAFTGEISPA 81
Cdd:COG0149    2 RKPLIAGNWKMNGTLAEAKALLAALAAALADlADVEVVVCPPFTYLAAVAEALAGSpIALGAQNVHWEDSGAYTGEISAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  82 MLKDVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQMCAYAKKI--RDWTN 159
Cdd:COG0149   82 MLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLsaEQAAN 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 160 VVVAYEPVWAIGTGKTATPDQAQEVHAFLRQWLTENISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLKPE 239
Cdd:COG0149  162 VVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGASLDAE 241


                 ....*...
gi 968061718 240 -FVDIVNA 246
Cdd:COG0149  242 dFLAIVRA 249
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 8-246 1.14e-124

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 353.74  E-value: 1.14e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718    8 VGGNWKMNGDQKSIAEICKVLSDAQLD-PNTDVVIGCPAIYLMFARNLLPCSIGVAGQNAYKVAKGAFTGEISPAMLKDV 86
Cdd:pfam00121   3 IAGNWKMNGTLAEAAELLAELAEALADeSGVEVVVAPPFTYLSAVAELLGSNIKVGAQNVDPEESGAFTGEISAEMLKDL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   87 GADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQMCAYAKKIRDWT-NVVVAYE 165
Cdd:pfam00121  83 GVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEQkNLVIAYE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  166 PVWAIGTGKTATPDQAQEVHAFLRQWLTEnISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLKPE-FVDIV 244
Cdd:pfam00121 163 PVWAIGTGKTATPEQAQEVHAFIRAVLAE-LYKEVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKAEdFLDII 241


                  ..
gi 968061718  245 NA 246
Cdd:pfam00121 242 NA 243
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 8-239 3.80e-55

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 175.76  E-value: 3.80e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718    8 VGGNWKM-NGDQKSIAEICKVLSDAQLDPN-TDVVIGCPAIYL-MFARNLlpcSIGVAGQNAYKVAKGAFTGEISPAMLK 84
Cdd:TIGR00419   2 VIGNWKTyNESRGMRALEVAKIAEEVASEAgVAVAVAPPFVDLpMIKREV---EIPVYAQHVDAVLSGAHTGEISAEMLK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   85 DVGADWVILGHSERRaiFKESDelIAEKAEHALAEGLKVIACIgetleereagrtnEVVARQMCAYAkkirdWTNVVVAY 164
Cdd:TIGR00419  79 DIGAKGTLINHSERR--MKLAD--IEKKIARLKELGLTSVVCT-------------NNVLTTAAAAA-----LEPDVVAV 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 968061718  165 EPVWAIGTGKTATPDQAQEVHAFLRqwltenISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLKPE 239
Cdd:TIGR00419 137 EPPELIGTGIPVSPAQPEVVHGSVR------AVKEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKAD 205
 
Name Accession Description Interval E-value
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 1-246 5.04e-131

triosephosphate isomerase; Provisional


Pssm-ID: 240365  Cd Length: 255  Bit Score: 370.01  E-value: 5.04e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   1 MSGRKFCVGGNWKMNGDQKSIAEICKVLSDAQLDP-NTDVVIGCPAIYLMFARNLLPCS-IGVAGQNAYKVAKGAFTGEI 78
Cdd:PTZ00333   1 MMKRKPFVGGNWKCNGTKASIKELIDSFNKLKFDPnNVDVVVAPPSLHIPLVQEKLKNKnFKISSQNVSLTGSGAFTGEI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  79 SPAMLKDVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQMCAYAKKIRD-- 156
Cdd:PTZ00333  81 SAEMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEEREAGQTSDVLSKQLEAIVKKVSDea 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 157 WTNVVVAYEPVWAIGTGKTATPDQAQEVHAFLRQWLTENISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASL 236
Cdd:PTZ00333 161 WDNIVIAYEPVWAIGTGKVATPEQAQEVHAFIRKWLAEKVGADVAEATRIIYGGSVNEKNCKELIKQPDIDGFLVGGASL 240

                        250
                 ....*....|
gi 968061718 237 KPEFVDIVNA 246
Cdd:PTZ00333 241 KPDFVDIIKS 250
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 6-245 2.15e-128

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 363.01  E-value: 2.15e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   6 FCVGGNWKMNGDQKSIAEICKVLSDAQLDP-NTDVVIGCPAIYLMFARNLLPCS-IGVAGQNAYKVAKGAFTGEISPAML 83
Cdd:cd00311    1 PLVAGNWKMNGTLAEALELAKALNAVLKDEsGVEVVVAPPFTYLAAVAEALEGSkIKVGAQNVSPEDSGAFTGEISAEML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  84 KDVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQMCAYAKKIRDWTNVVVA 163
Cdd:cd00311   81 KDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGVEDLAPVVIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 164 YEPVWAIGTGKTATPDQAQEVHAFLRQWLTENISkEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLKPE-FVD 242
Cdd:cd00311  161 YEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYG-EVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKAEsFLD 239


                 ...
gi 968061718 243 IVN 245
Cdd:cd00311  240 IIK 242
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 4-246 5.48e-125

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 354.75  E-value: 5.48e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   4 RKFCVGGNWKMNGDQKSIAEICKVLSDAQLD-PNTDVVIGCPAIYLMFARNLLPCS-IGVAGQNAYKVAKGAFTGEISPA 81
Cdd:COG0149    2 RKPLIAGNWKMNGTLAEAKALLAALAAALADlADVEVVVCPPFTYLAAVAEALAGSpIALGAQNVHWEDSGAYTGEISAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  82 MLKDVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQMCAYAKKI--RDWTN 159
Cdd:COG0149   82 MLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLsaEQAAN 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 160 VVVAYEPVWAIGTGKTATPDQAQEVHAFLRQWLTENISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLKPE 239
Cdd:COG0149  162 VVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGASLDAE 241


                 ....*...
gi 968061718 240 -FVDIVNA 246
Cdd:COG0149  242 dFLAIVRA 249
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 8-246 1.14e-124

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 353.74  E-value: 1.14e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718    8 VGGNWKMNGDQKSIAEICKVLSDAQLD-PNTDVVIGCPAIYLMFARNLLPCSIGVAGQNAYKVAKGAFTGEISPAMLKDV 86
Cdd:pfam00121   3 IAGNWKMNGTLAEAAELLAELAEALADeSGVEVVVAPPFTYLSAVAELLGSNIKVGAQNVDPEESGAFTGEISAEMLKDL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   87 GADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQMCAYAKKIRDWT-NVVVAYE 165
Cdd:pfam00121  83 GVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEQkNLVIAYE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  166 PVWAIGTGKTATPDQAQEVHAFLRQWLTEnISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLKPE-FVDIV 244
Cdd:pfam00121 163 PVWAIGTGKTATPEQAQEVHAFIRAVLAE-LYKEVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKAEdFLDII 241


                  ..
gi 968061718  245 NA 246
Cdd:pfam00121 242 NA 243
tpiA PRK00042
triosephosphate isomerase; Provisional
 4-246 5.55e-121

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 344.41  E-value: 5.55e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   4 RKFCVGGNWKMNGDQKSIAEICKVLSDAQLD-PNTDVVIGCPAIYLMFARNLLPCS-IGVAGQNAYKVAKGAFTGEISPA 81
Cdd:PRK00042   1 RKPIIAGNWKMNKTLAEAKALVEELKAALPDaDGVEVAVAPPFTALASVKEALKGSnIKLGAQNVHPEDSGAFTGEISAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  82 MLKDVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQMCAYAKKI--RDWTN 159
Cdd:PRK00042  81 MLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLsaEQFAN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 160 VVVAYEPVWAIGTGKTATPDQAQEVHAFLRQWLTEnISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLKPE 239
Cdd:PRK00042 161 LVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAE-LYGEVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASLKAE 239


                 ....*...
gi 968061718 240 -FVDIVNA 246
Cdd:PRK00042 240 dFLAIVKA 247
PLN02561 PLN02561
triosephosphate isomerase
 3-246 2.41e-118

triosephosphate isomerase


Pssm-ID: 178175  Cd Length: 253  Bit Score: 337.95  E-value: 2.41e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   3 GRKFCVGGNWKMNGDQKSIAEICKVLSDAQLdPNTD---VVIGCPAIYLMFARNLLPCSIGVAGQNAYKVAKGAFTGEIS 79
Cdd:PLN02561   2 ARKFFVGGNWKCNGTVEEVKKIVTTLNEAEV-PSEDvveVVVSPPFVFLPLVKSLLRPDFQVAAQNCWVKKGGAFTGEIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  80 PAMLKDVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQMCAYAKKIRDWTN 159
Cdd:PLN02561  81 AEMLVNLGIPWVILGHSERRALLGESNEFVGDKVAYALSQGLKVIACVGETLEQRESGSTMDVVAAQTKAIADKVSDWAN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 160 VVVAYEPVWAIGTGKTATPDQAQEVHAFLRQWLTENISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLKPE 239
Cdd:PLN02561 161 VVLAYEPVWAIGTGKVATPAQAQEVHDELRKWLHKNVSPEVAATTRIIYGGSVTGANCKELAAQPDVDGFLVGGASLKPE 240


                 ....*..
gi 968061718 240 FVDIVNA 246
Cdd:PLN02561 241 FIDIIKS 247
PLN02429 PLN02429
triosephosphate isomerase
 5-246 8.86e-88

triosephosphate isomerase


Pssm-ID: 166070  Cd Length: 315  Bit Score: 262.80  E-value: 8.86e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   5 KFCVGGNWKMNGDQKSIAEICKVLSDAQLDPNTDVVIGCPAIYLMFARNLLPCSIGVAGQNAYKVAKGAFTGEISPAMLK 84
Cdd:PLN02429  65 KFFVGGNWKCNGTKDSIAKLISDLNSATLEADVDVVVSPPFVYIDQVKSSLTDRIDISGQNSWVGKGGAFTGEISVEQLK 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  85 DVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQMCAYAKKIRDWTNVVVAY 164
Cdd:PLN02429 145 DLGCKWVILGHSERRHVIGEKDEFIGKKAAYALSEGLGVIACIGEKLEEREAGKTFDVCFAQLKAFADAVPSWDNIVVAY 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 165 EPVWAIGTGKTATPDQAQEVHAFLRQWLTENISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLK-PEFVDI 243
Cdd:PLN02429 225 EPVWAIGTGKVASPQQAQEVHVAVRGWLKKNVSEEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGASLKgPEFATI 304


                 ...
gi 968061718 244 VNA 246
Cdd:PLN02429 305 VNS 307
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
 4-246 8.21e-84

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 262.36  E-value: 8.21e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   4 RKFCVGGNWKMNGDQKSIAEICKVLSDAQLDPNTDVVIGCPAIYLMFARNLLPCS-IGVAGQNAYKVAKGAFTGEISPAM 82
Cdd:PRK13962 397 RKPIIAGNWKMNKTPAEAKEFVNELKKYVKDAQAEVVVCPPFTALPSVKEAVDGSnIKLGAQNVFYEEKGAYTGEISGPM 476

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  83 LKDVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQMCA--YAKKIRDWTNV 160
Cdd:PRK13962 477 LAEIGVEYVIIGHSERRQYFGETDELVNKKVLAALKAGLTPILCVGETLDERESGITFDVVRLQLKAalNGLSAEQVKKV 556

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 161 VVAYEPVWAIGTGKTATPDQAQEVHAFLRQWLTENISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLKP-E 239
Cdd:PRK13962 557 VIAYEPVWAIGTGKVATPEQAQEVHAFIRKLVAELYGEEAARKVRILYGGSVKSENAAGLFNQPDIDGGLVGGASLKAqE 636


                 ....*..
gi 968061718 240 FVDIVNA 246
Cdd:PRK13962 637 FAAIANY 643
PRK14565 PRK14565
triosephosphate isomerase; Provisional
 1-244 1.11e-58

triosephosphate isomerase; Provisional


Pssm-ID: 237758  Cd Length: 237  Bit Score: 185.73  E-value: 1.11e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   1 MSgrkFCVGGNWKMNGDQKSIAEICKVLSD--AQLDPNTDVVIgCPAIYLMFARNLLPCSIGVAGQNAYKVAKGAFTGEI 78
Cdd:PRK14565   1 MS---FLIVANWKMNGDFSLFSSFLKELSNklANNEITLKLVI-CPPFTAMSSFVECNPNIKLGAQNCFYGSSGGYTGEI 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  79 SPAMLKDVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGRTNEVVARQmCayAKKIRDWT 158
Cdd:PRK14565  77 SAKMLKECGCSYVILGHSERRSTFHETDSDIRLKAESAIESGLIPIICVGETLEDRENGMTKDVLLEQ-C--SNCLPKHG 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 159 NVVVAYEPVWAIGTGKtaTPDQAQEVHAFlrqwlteNISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLKP 238
Cdd:PRK14565 154 EFIIAYEPVWAIGGST--IPSNDAIAEAF-------EIIRSYDSKSHIIYGGSVNQENIRDLKSINQLSGVLVGSASLDV 224


                 ....*..
gi 968061718 239 E-FVDIV 244
Cdd:PRK14565 225 DsFCKII 231
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 8-239 3.80e-55

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 175.76  E-value: 3.80e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718    8 VGGNWKM-NGDQKSIAEICKVLSDAQLDPN-TDVVIGCPAIYL-MFARNLlpcSIGVAGQNAYKVAKGAFTGEISPAMLK 84
Cdd:TIGR00419   2 VIGNWKTyNESRGMRALEVAKIAEEVASEAgVAVAVAPPFVDLpMIKREV---EIPVYAQHVDAVLSGAHTGEISAEMLK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718   85 DVGADWVILGHSERRaiFKESDelIAEKAEHALAEGLKVIACIgetleereagrtnEVVARQMCAYAkkirdWTNVVVAY 164
Cdd:TIGR00419  79 DIGAKGTLINHSERR--MKLAD--IEKKIARLKELGLTSVVCT-------------NNVLTTAAAAA-----LEPDVVAV 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 968061718  165 EPVWAIGTGKTATPDQAQEVHAFLRqwltenISKEVSNTLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLKPE 239
Cdd:TIGR00419 137 EPPELIGTGIPVSPAQPEVVHGSVR------AVKEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKAD 205
PRK14905 PRK14905
triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; ...
 59-232 2.27e-42

triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional


Pssm-ID: 184898 [Multi-domain]  Cd Length: 355  Bit Score: 147.49  E-value: 2.27e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  59 IGVAGQNAYKVAKGAFTGEISPAMLKDVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGR 138
Cdd:PRK14905  67 IKIGAQNMNAKDKGQFTGEISPLMLKELGIELVMIGHSERRHVLKETDQEENEKVLAALKHGFITLLCIGETLEQKNYNI 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 139 TNEVVARQM--CAYAKKIRDWTNVVVAYEPVWAIGTGKT-ATPDQAQEVHAFLRQWLTENISKEvSNTLRIQYGGSVTAA 215
Cdd:PRK14905 147 SDEVLRTQLkiGLHGVSAEQLPHLFIAYEPVWAIGEGGIpASAEYADEKHAIIKQCLFELFAEE-SKKIPVLYGGSVNLE 225

                        170
                 ....*....|....*..
gi 968061718 216 NAKELAKKPDIDGFLVG 232
Cdd:PRK14905 226 NANELIMKPHIDGLFIG 242
PRK15492 PRK15492
triosephosphate isomerase; Provisional
 59-232 9.42e-39

triosephosphate isomerase; Provisional


Pssm-ID: 185389  Cd Length: 260  Bit Score: 135.50  E-value: 9.42e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  59 IGVAGQNAYKVAKGAFTGEISPAMLKDVGADWVILGHSERRAIFKESDELIAEKAEHALAEGLKVIACIGETLEEREAGR 138
Cdd:PRK15492  66 IIIGAQNMNPNDNGQFTGDISPLMLKEIGTQLVMIGHSERRHKFGETDQEENAKVLAALKHDFTTLLCVGETLEQKNYGI 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718 139 TNEVVARQMCAYAKKIR--DWTNVVVAYEPVWAIGT-GKTATPDQAQEVHAFLRQWLTEnISKEVSNTLRIQYGGSVTAA 215
Cdd:PRK15492 146 SDEILRTQLKIGLHGINpdQLAKLRIAYEPVWAIGEaGIPASADYADEKHAVIKQCLIE-LFGDAGDDIPVFYGGSVNAE 224

                        170
                 ....*....|....*..
gi 968061718 216 NAKELAKKPDIDGFLVG 232
Cdd:PRK15492 225 NANELFGQPHIDGLFIG 241
PRK04302 PRK04302
triosephosphate isomerase; Provisional
 21-126 3.22e-08

triosephosphate isomerase; Provisional


Pssm-ID: 235274  Cd Length: 223  Bit Score: 52.56  E-value: 3.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968061718  21 IAEICKVLSDaqldpNTDVVIGCPAIYLMFARNLLPCSIGVAGQNAYKVAKGAFTGEISPAMLKDVGADWVILGHSERRA 100
Cdd:PRK04302  24 IAKAAEKVSK-----ETGVRIAVAPQALDIRRVAEEVDIPVYAQHVDPVEPGSHTGHILPEAVKDAGAVGTLINHSERRL 98

                         90       100
                 ....*....|....*....|....*.
gi 968061718 101 IFKEsdelIAEKAEHALAEGLKVIAC 126
Cdd:PRK04302  99 TLAD----IEAVVERAKKLGLESVVC 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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