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Conserved domains on  [gi|961710477|ref|XP_014931463|]
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FK506-binding protein 15 isoform X1 [Acinonyx jubatus]

Protein Classification

FKBP_C and Smc domain-containing protein( domain architecture ID 13624727)

protein containing domains FKBP_C, Smc, and PHA03247

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
193-286 9.24e-26

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 102.27  E-value: 9.24e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   193 AVEVGDSLEVAYTSWLLQnhvlGQVLDSTANKDKLLRLKLGSGKVIKAWEDGMLGMKKGGKRLLVIPPACAAGSEGVTGW 272
Cdd:pfam00254    4 KAKKGDRVTVHYTGTLED----GTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGP 79

                           90
                   ....*....|....
gi 961710477   273 TQSPDSILVYEVEM 286
Cdd:pfam00254   80 VIPPNATLVFEVEL 93
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 567-839 1.96e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 98.09  E-value: 1.96e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  567 IQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEntqarvlhAEQEKAKVTEELT 646
Cdd:COG1196   262 LAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEE--------LEEELAELEEELE 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  647 AATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLE 726
Cdd:COG1196   334 ELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALL 413

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  727 EELADLRAEKESLEKNLSERKKKSAQERcRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQTQWE 806
Cdd:COG1196   414 ERLERLEEELEELEEALAELEEEEEEEE-EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAAR 492

                         250       260       270
                  ....*....|....*....|....*....|...
gi 961710477  807 akcEHLLASAKDEHLLQYQEVCAQRDASQQELL 839
Cdd:COG1196   493 ---LLLLLEAEADYEGFLEGVKAALLLAGLRGL 522
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 307-499 1.47e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   307 SAAPSPIPGADSLSADPVVSPPTSVPFKSGEPALRIKSnslneqlTVNTNPDTVKAKLISRMAKMgQPMLPILPPQLDSN 386
Cdd:pfam03154  192 TQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHT-------LIQQTPTLHPQRLPSPHPPL-QPMTQPPPPSQVSP 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   387 DSEIEEVntVRGAGQPVATP-SMQPSLQPaHPVLPQMTSQAPQPSVSglQAPsaalmqvasLDSHSAVSGNAQSFQpyag 465
Cdd:pfam03154  264 QPLPQPS--LHGQMPPMPHSlQTGPSHMQ-HPVPPQPFPLTPQSSQS--QVP---------PGPSPAAPGQSQQRI---- 325

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 961710477   466 mqayAYPHASAVTSQLQPAR--PLYPTPLSQsPHFQ 499
Cdd:pfam03154  326 ----HTPPSQSQLQSQQPPReqPLPPAPLSM-PHIK 356
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 951-1129 2.74e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  951 PRQPSVSGSAGPPPVPlSGEMQGSPSLSPEQAVQEAVPPPPRVlsTPQEEVQGREGEPSEAEALSeieEGSLSPELTCGP 1030
Cdd:PHA03247 2878 PARPPVRRLARPAVSR-STESFALPPDQPERPPQPQAPPPPQP--QPQPPPPPQPQPPPPPPPRP---QPPLAPTTDPAG 2951

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477 1031 SQRALGPPTSVPPMPPGPVLVDSECEETLASAlenPCVEEPESTARlSLTSHLLKGDPLASGSESPGEEPQPP--ELKK- 1107
Cdd:PHA03247 2952 AGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA---PSREAPASSTP-PLTGHSLSRVSSWASSLALHEETDPPpvSLKQt 3027

                         170       180
                  ....*....|....*....|....*...
gi 961710477 1108 ------DEDVTSSAIPYREPGGTEAGSP 1129
Cdd:PHA03247 3028 lwppddTEDSDADSLFDSDSERSDLEAL 3055
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
193-286 9.24e-26

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 102.27  E-value: 9.24e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   193 AVEVGDSLEVAYTSWLLQnhvlGQVLDSTANKDKLLRLKLGSGKVIKAWEDGMLGMKKGGKRLLVIPPACAAGSEGVTGW 272
Cdd:pfam00254    4 KAKKGDRVTVHYTGTLED----GTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGP 79

                           90
                   ....*....|....
gi 961710477   273 TQSPDSILVYEVEM 286
Cdd:pfam00254   80 VIPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 184-285 1.03e-22

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 93.71  E-value: 1.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  184 QDLVVVEGPAVEVGDSLEVAYTSWLLQnhvlGQVLDSTANKDKLLRLKLGSGKVIKAWEDGMLGMKKGGKRLLVIPPACA 263
Cdd:COG0545     4 KVLKEGTGAKPKAGDTVTVHYTGTLLD----GTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELA 79

                          90       100
                  ....*....|....*....|..
gi 961710477  264 AGSEGVTGwTQSPDSILVYEVE 285
Cdd:COG0545    80 YGERGAGG-VIPPNSTLVFEVE 100
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 567-839 1.96e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 98.09  E-value: 1.96e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  567 IQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEntqarvlhAEQEKAKVTEELT 646
Cdd:COG1196   262 LAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEE--------LEEELAELEEELE 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  647 AATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLE 726
Cdd:COG1196   334 ELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALL 413

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  727 EELADLRAEKESLEKNLSERKKKSAQERcRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQTQWE 806
Cdd:COG1196   414 ERLERLEEELEELEEALAELEEEEEEEE-EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAAR 492

                         250       260       270
                  ....*....|....*....|....*....|...
gi 961710477  807 akcEHLLASAKDEHLLQYQEVCAQRDASQQELL 839
Cdd:COG1196   493 ---LLLLLEAEADYEGFLEGVKAALLLAGLRGL 522
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 566-859 3.25e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 87.80  E-value: 3.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   566 NIQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMmEKRNNSLQTATENTQARVLHAEQEKAKVTEEL 645
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISAL-RKDLARLEAEVEQLEERIAQLSKELTELEAEI 763

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   646 TAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSL 725
Cdd:TIGR02168  764 EELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDL 843

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   726 EEELADLRAEKESLEKNLSE----RKKKSAQ------ERCRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLS 795
Cdd:TIGR02168  844 EEQIEELSEDIESLAAEIEEleelIEELESEleallnERASLEEALALLRSELEELSEELRELESKRSELRRELEELREK 923

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 961710477   796 LVQAELQ-TQWEAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQN 859
Cdd:TIGR02168  924 LAQLELRlEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGPVN 988
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 509-935 1.12e-11

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 69.37  E-value: 1.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   509 MTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSLLLPSMSVTMET--SMIMGNIQRIIQENERLK---QEILE 583
Cdd:pfam05483  309 MSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSleELLRTEQQRLEKNEDQLKiitMELQK 388

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   584 KSSRIEE----QNDKISELIERNQRYVEQSNLMMEKRNnsLQTATENTQARvlhaEQEkakVTEELTAATAQVSRLQLKV 659
Cdd:pfam05483  389 KSSELEEmtkfKNNKEVELEELKKILAEDEKLLDEKKQ--FEKIAEELKGK----EQE---LIFLLQAREKEIHDLEIQL 459

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   660 TA-------HQKKEAELQMQL-TESLKETDLlKGQLIKLQAELSEL-QETSE-------QAQSKFKSEKQSRRQLElKVT 723
Cdd:pfam05483  460 TAiktseehYLKEVEDLKTELeKEKLKNIEL-TAHCDKLLLENKELtQEASDmtlelkkHQEDIINCKKQEERMLK-QIE 537

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   724 SLEEELADLRAEKESLEKnlsERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLK--------KARVSTDQAAAEQLS 795
Cdd:pfam05483  538 NLEEKEMNLRDELESVRE---EFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKIlenkcnnlKKQIENKNKNIEELH 614

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   796 LVQAELQTQWEAKCEHL-------------LASAK---DEHLLQYQEVCAQRDASQQELLRLQEKclalqAQVTALTEQN 859
Cdd:pfam05483  615 QENKALKKKGSAENKQLnayeikvnkleleLASAKqkfEEIIDNYQKEIEDKKISEEKLLEEVEK-----AKAIADEAVK 689

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   860 EQHTKDLENKSHMSGVAAAAtdpsEKVKKIMNQVFQSLRGEFEL-----EESYNGRAVLGTIMNTIKMVTLQLLNQHEQD 934
Cdd:pfam05483  690 LQKEIDKRCQHKIAEMVALM----EKHKHQYDKIIEERDSELGLyknkeQEQSSAKAALEIELSNIKAELLSLKKQLEIE 765


                   .
gi 961710477   935 K 935
Cdd:pfam05483  766 K 766
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
508-782 6.42e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 67.01  E-value: 6.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  508 LMTEARQHNTEIRMaVSKVADKMDHLMTKVEELQKhsagnslllpsmsvtmETSMIMGNIQRI---IQENERLKQEILEK 584
Cdd:PRK03918  212 ISSELPELREELEK-LEKEVKELEELKEEIEELEK----------------ELESLEGSKRKLeekIRELEERIEELKKE 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  585 SSRIEEQNDKISELIERNQRYVEQSNLM---------MEKRNNSLQTATENTQARVLHAEQEKAKVtEELTaataqvsrl 655
Cdd:PRK03918  275 IEELEEKVKELKELKEKAEEYIKLSEFYeeyldelreIEKRLSRLEEEINGIEERIKELEEKEERL-EELK--------- 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  656 qlkvtahqKKEAELQ---MQLTESLKETDL---LKGQLIKLQAELSELqeTSEQAQSKFKSEKQSRRQLELKVTSLEEEL 729
Cdd:PRK03918  345 --------KKLKELEkrlEELEERHELYEEakaKKEELERLKKRLTGL--TPEKLEKELEELEKAKEEIEEEISKITARI 414

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 961710477  730 ADLRAEKESLEKNLSERKKksAQERCR------AEEEIDEIRKSYQEELDKLRQLLKKA 782
Cdd:PRK03918  415 GELKKEIKELKKAIEELKK--AKGKCPvcgrelTEEHRKELLEEYTAELKRIEKELKEI 471
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 191-309 2.14e-07

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 53.61  E-value: 2.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  191 GPAVEVGDSLEVAYTSWLLQnhvlGQVLDSTANKDKLLRLKLGSgkVIKAWEDGMLGMKKGGKRLLVIPPACAAGSEGVT 270
Cdd:PRK10902  158 GEAPKDSDTVVVNYKGTLID----GKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVP 231

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 961710477  271 GWtqSPDSILVYEVEMRRVKFARDSGSDGHSVSSRDSAA 309
Cdd:PRK10902  232 GI--PANSTLVFDVELLDVKPAPKADAKPEADAKAADSA 268
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 635-778 5.82e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 43.47  E-value: 5.82e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477    635 EQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTE--SLKETDLLKgqlikLQAELSELQETSEQAQSKFKSEK 712
Cdd:smart00787  157 KEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDEleDCDPTELDR-----AKEKLKKLLQEIMIKVKKLEELE 231

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 961710477    713 QSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAqercraeeeiDEIRKsYQEELDKLRQL 778
Cdd:smart00787  232 EELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTF----------KEIEK-LKEQLKLLQSL 286
growth_prot_Scy NF041483
polarized growth protein Scy;
632-902 5.98e-04

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 44.43  E-value: 5.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  632 LHAEQEKAKVTEELTAATAQVSRLqlkVTAHQKKEAELQMQL-TESLKETDllkgqliKLQAELSELQETSEQ------- 703
Cdd:NF041483   83 IQADQLRADAERELRDARAQTQRI---LQEHAEHQARLQAELhTEAVQRRQ-------QLDQELAERRQTVEShvnenva 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  704 --AQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAqERCRAEEEIDEIRKSYQEEldklrQLLKK 781
Cdd:NF041483  153 waEQLRARTESQARRLLDESRAEAEQALAAARAEAERLAEEARQRLGSEA-ESARAEAEAILRRARKDAE-----RLLNA 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  782 ARVSTDQAA--AEQLSLVQAELQTQWEAKCEHLLASAkdEHLLQYQEVcAQRDASQQELLRLQEKCLALQAQVTALTEQN 859
Cdd:NF041483  227 ASTQAQEATdhAEQLRSSTAAESDQARRQAAELSRAA--EQRMQEAEE-ALREARAEAEKVVAEAKEAAAKQLASAESAN 303

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 961710477  860 EQHTKdlENKSHMSGVAAAATDPSEKVKKIMNQVFQSLRGEFE 902
Cdd:NF041483  304 EQRTR--TAKEEIARLVGEATKEAEALKAEAEQALADARAEAE 344
iSH2_PI3K_IA_R cd12923
Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory ...
 598-752 6.89e-04

Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; PI3Ks catalyze the transfer of the gamma-phosphoryl group from ATP to the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives. They play an important role in a variety of fundamental cellular processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, immune cell activation, and apoptosis. They are classified according to their substrate specificity, regulation, and domain structure. Class IA PI3Ks are heterodimers of a p110 catalytic (C) subunit and a p85-related regulatory (R) subunit. The R subunit down-regulates PI3K basal activity, stabilizes the C subunit, and plays a role in the activation downstream of tyrosine kinases. All R subunits contain two SH2 domains that flank an intervening helical domain (iSH2), which binds to the N-terminal adaptor-binding domain (ABD) of the catalytic subunit. In vertebrates, there are three genes (PIK3R1, PIK3R2, and PIK3R3) that encode for different Class IA PI3K R subunits.


Pssm-ID: 214016 [Multi-domain]  Cd Length: 152  Bit Score: 41.44  E-value: 6.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  598 LIERNQRYVEQSNlMMEKRNNSLQTATENTQAR--VLHAEQEKAKVTEEltaataqvsrlQLKVTAHQKKEAELQ--MQL 673
Cdd:cd12923    10 LKEINKEYLDKSR-EYDELYEKYNKLSQEIQLKrqALEAFEEAVKMFEE-----------QLRTQEKFQKEAQPHekQRL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 961710477  674 TESLKetdllkgqliKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQ 752
Cdd:cd12923    78 MENNE----------LLKSRLKELEESKEQLEEDLRKQVAYNRELEREMNSLKPELMQLRKQKDQYLRWLKRKGVSQEE 146
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 307-499 1.47e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   307 SAAPSPIPGADSLSADPVVSPPTSVPFKSGEPALRIKSnslneqlTVNTNPDTVKAKLISRMAKMgQPMLPILPPQLDSN 386
Cdd:pfam03154  192 TQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHT-------LIQQTPTLHPQRLPSPHPPL-QPMTQPPPPSQVSP 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   387 DSEIEEVntVRGAGQPVATP-SMQPSLQPaHPVLPQMTSQAPQPSVSglQAPsaalmqvasLDSHSAVSGNAQSFQpyag 465
Cdd:pfam03154  264 QPLPQPS--LHGQMPPMPHSlQTGPSHMQ-HPVPPQPFPLTPQSSQS--QVP---------PGPSPAAPGQSQQRI---- 325

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 961710477   466 mqayAYPHASAVTSQLQPAR--PLYPTPLSQsPHFQ 499
Cdd:pfam03154  326 ----HTPPSQSQLQSQQPPReqPLPPAPLSM-PHIK 356
PHA03247 PHA03247
large tegument protein UL36; Provisional
 951-1129 2.74e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  951 PRQPSVSGSAGPPPVPlSGEMQGSPSLSPEQAVQEAVPPPPRVlsTPQEEVQGREGEPSEAEALSeieEGSLSPELTCGP 1030
Cdd:PHA03247 2878 PARPPVRRLARPAVSR-STESFALPPDQPERPPQPQAPPPPQP--QPQPPPPPQPQPPPPPPPRP---QPPLAPTTDPAG 2951

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477 1031 SQRALGPPTSVPPMPPGPVLVDSECEETLASAlenPCVEEPESTARlSLTSHLLKGDPLASGSESPGEEPQPP--ELKK- 1107
Cdd:PHA03247 2952 AGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA---PSREAPASSTP-PLTGHSLSRVSSWASSLALHEETDPPpvSLKQt 3027

                         170       180
                  ....*....|....*....|....*...
gi 961710477 1108 ------DEDVTSSAIPYREPGGTEAGSP 1129
Cdd:PHA03247 3028 lwppddTEDSDADSLFDSDSERSDLEAL 3055
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 561-782 8.88e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 40.38  E-value: 8.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  561 SMIMGNIqrIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKR--------NNSLQtATENTQARVL 632
Cdd:NF033838   28 SLFLGGV--VHAEEVRGGNNPTVTSSGNESQKEHAKEVESHLEKILSEIQKSLDKRkhtqnvalNKKLS-DIKTEYLYEL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  633 HAEQEKA------KVTEELTAATAQ----VSRLQLKVTAHQKKEAELQMQlTESLKETDLLKGQLI---KLQAELSELQE 699
Cdd:NF033838  105 NVLKEKSeaeltsKTKKELDAAFEQfkkdTLEPGKKVAEATKKVEEAEKK-AKDQKEEDRRNYPTNtykTLELEIAESDV 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  700 TSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKK--KSAQERCRAEEEIDEIRKSYQEELDKLRQ 777
Cdd:NF033838  184 EVKKAELELVKEEAKEPRDEEKIKQAKAKVESKKAEATRLEKIKTDREKaeEEAKRRADAKLKEAVEKNVATSEQDKPKR 263


                  ....*
gi 961710477  778 LLKKA 782
Cdd:NF033838  264 RAKRG 268
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
193-286 9.24e-26

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 102.27  E-value: 9.24e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   193 AVEVGDSLEVAYTSWLLQnhvlGQVLDSTANKDKLLRLKLGSGKVIKAWEDGMLGMKKGGKRLLVIPPACAAGSEGVTGW 272
Cdd:pfam00254    4 KAKKGDRVTVHYTGTLED----GTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGP 79

                           90
                   ....*....|....
gi 961710477   273 TQSPDSILVYEVEM 286
Cdd:pfam00254   80 VIPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 184-285 1.03e-22

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 93.71  E-value: 1.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  184 QDLVVVEGPAVEVGDSLEVAYTSWLLQnhvlGQVLDSTANKDKLLRLKLGSGKVIKAWEDGMLGMKKGGKRLLVIPPACA 263
Cdd:COG0545     4 KVLKEGTGAKPKAGDTVTVHYTGTLLD----GTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELA 79

                          90       100
                  ....*....|....*....|..
gi 961710477  264 AGSEGVTGwTQSPDSILVYEVE 285
Cdd:COG0545    80 YGERGAGG-VIPPNSTLVFEVE 100
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 567-839 1.96e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 98.09  E-value: 1.96e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  567 IQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEntqarvlhAEQEKAKVTEELT 646
Cdd:COG1196   262 LAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEE--------LEEELAELEEELE 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  647 AATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLE 726
Cdd:COG1196   334 ELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALL 413

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  727 EELADLRAEKESLEKNLSERKKKSAQERcRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQTQWE 806
Cdd:COG1196   414 ERLERLEEELEELEEALAELEEEEEEEE-EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAAR 492

                         250       260       270
                  ....*....|....*....|....*....|...
gi 961710477  807 akcEHLLASAKDEHLLQYQEVCAQRDASQQELL 839
Cdd:COG1196   493 ---LLLLLEAEADYEGFLEGVKAALLLAGLRGL 522
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 620-867 6.24e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 96.16  E-value: 6.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  620 LQTATENTQARVLHAEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQE 699
Cdd:COG1196   237 LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  700 TSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLL 779
Cdd:COG1196   317 RLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAA 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  780 -KKARVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLLQyqevcAQRDASQQELLRLQEKCLALQAQVTALTEQ 858
Cdd:COG1196   397 eLAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE-----EALEEAAEEEAELEEEEEALLELLAELLEE 471


                  ....*....
gi 961710477  859 NEQHTKDLE 867
Cdd:COG1196   472 AALLEAALA 480
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 569-878 8.06e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 96.16  E-value: 8.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  569 RIIQENERLKQ------EILEKSSRIEEQNDKISELIERNQRYVEQSNLmmekrnnsLQTATENTQARVLHAEQEKAKVT 642
Cdd:COG1196   216 RELKEELKELEaellllKLRELEAELEELEAELEELEAELEELEAELAE--------LEAELEELRLELEELELELEEAQ 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  643 EELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKV 722
Cdd:COG1196   288 AEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEAL 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  723 TSLEEELADLRAEKESLEKNLSERKKKSAQERcRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQ 802
Cdd:COG1196   368 LEAEAELAEAEEELEELAEELLEALRAAAELA-AQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEE 446

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 961710477  803 TQWEAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLA---LQAQVTALTEQNEQHTKDLENKSHMSGVAAA 878
Cdd:COG1196   447 AAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAArllLLLEAEADYEGFLEGVKAALLLAGLRGLAGA 525
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 566-859 3.25e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 87.80  E-value: 3.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   566 NIQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMmEKRNNSLQTATENTQARVLHAEQEKAKVTEEL 645
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISAL-RKDLARLEAEVEQLEERIAQLSKELTELEAEI 763

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   646 TAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSL 725
Cdd:TIGR02168  764 EELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDL 843

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   726 EEELADLRAEKESLEKNLSE----RKKKSAQ------ERCRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLS 795
Cdd:TIGR02168  844 EEQIEELSEDIESLAAEIEEleelIEELESEleallnERASLEEALALLRSELEELSEELRELESKRSELRRELEELREK 923

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 961710477   796 LVQAELQ-TQWEAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQN 859
Cdd:TIGR02168  924 LAQLELRlEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGPVN 988
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 572-870 7.48e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.65  E-value: 7.48e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   572 QEN-ERLkQEILEKssrIEEQNDKISELIERNQRYVEQSNlmmEKRN----------NSLQTATENTQARVLHAEQEKAK 640
Cdd:TIGR02168  185 RENlDRL-EDILNE---LERQLKSLERQAEKAERYKELKA---ELRElelallvlrlEELREELEELQEELKEAEEELEE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   641 VTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLEL 720
Cdd:TIGR02168  258 LTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAE 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   721 KVTSLEEELADLRAEKESLEKNLSERKKKsAQERCRAEEEIDEIRKSYQEELDKLRQLLKK--ARVSTDQAAAEQLSLVQ 798
Cdd:TIGR02168  338 ELAELEEKLEELKEELESLEAELEELEAE-LEELESRLEELEEQLETLRSKVAQLELQIASlnNEIERLEARLERLEDRR 416

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 961710477   799 AELQTQWEAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQNEQHTKDLENKS 870
Cdd:TIGR02168  417 ERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQ 488
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 573-858 4.19e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 80.88  E-value: 4.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   573 ENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSN-------LMMEKRN----------NSLQTATENTQARVLHAE 635
Cdd:TIGR02169  171 KKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREkaeryqaLLKEKREyegyellkekEALERQKEAIERQLASLE 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   636 QEKAKVTEE--------------LTAATAQVS--------RLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAE 693
Cdd:TIGR02169  251 EELEKLTEEiselekrleeieqlLEELNKKIKdlgeeeqlRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAE 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   694 LSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEiRKSYQEELD 773
Cdd:TIGR02169  331 IDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKRE-INELKRELD 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   774 KLRQLLKK--ARVSTDQAAAEQLSLVQAELQTQWEAKCEHLlasAKDEHLLqyQEVCAQRDASQQELLRLQEKCLALQAQ 851
Cdd:TIGR02169  410 RLQEELQRlsEELADLNAAIAGIEAKINELEEEKEDKALEI---KKQEWKL--EQLAADLSKYEQELYDLKEEYDRVEKE 484


                   ....*..
gi 961710477   852 VTALTEQ 858
Cdd:TIGR02169  485 LSKLQRE 491
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 565-882 2.24e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 78.44  E-value: 2.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  565 GNIQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLmMEKRNNSLQTATENTQARVLHAEQEKAKVTEE 644
Cdd:COG1196   288 AEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEE-LEEELEELEEELEEAEEELEEAEAELAEAEEA 366

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  645 LTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTS 724
Cdd:COG1196   367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEE 446

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  725 LEEELADLRAEKESLEKNLSERKKKSAQercrAEEEIDEIRKSyQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQT- 803
Cdd:COG1196   447 AAEEEAELEEEEEALLELLAELLEEAAL----LEAALAELLEE-LAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRg 521

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  804 ---------QWEAKCEHLLASAKDEhLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQNEQHTKDLENKSHMSG 874
Cdd:COG1196   522 lagavavliGVEAAYEAALEAALAA-ALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAA 600


                  ....*...
gi 961710477  875 VAAAATDP 882
Cdd:COG1196   601 VDLVASDL 608
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 656-868 2.75e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 74.59  E-value: 2.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  656 QLKVTAHQKKEAELQMQLTESLKETD--LLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLR 733
Cdd:COG1196   201 QLEPLERQAEKAERYRELKEELKELEaeLLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELE 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  734 AEKESL---EKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLlkKARVSTDQAAAEQLSLVQAELQTQWEAKCE 810
Cdd:COG1196   281 LELEEAqaeEYELLAELARLEQDIARLEERRRELEERLEELEEELAEL--EEELEELEEELEELEEELEEAEEELEEAEA 358

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  811 HL--LASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQNEQHTKDLEN 868
Cdd:COG1196   359 ELaeAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLER 418
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 571-837 3.98e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 74.33  E-value: 3.98e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   571 IQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARV------LHAEQEKAKVT-- 642
Cdd:TIGR02169  232 KEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVkekigeLEAEIASLERSia 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   643 ---EELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQsrrqle 719
Cdd:TIGR02169  312 ekeRELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRD------ 385

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   720 lKVTSLEEELADLRAEKESLEKNLS---ERKKKSAQERCRAEEEIDEIR---KSYQEELDKLRQLLKKARVSTDQaAAEQ 793
Cdd:TIGR02169  386 -ELKDYREKLEKLKREINELKRELDrlqEELQRLSEELADLNAAIAGIEakiNELEEEKEDKALEIKKQEWKLEQ-LAAD 463

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 961710477   794 LSLVQAELQ--TQWEAKCEHLLASAKDEhllqYQEVCAQRDASQQE 837
Cdd:TIGR02169  464 LSKYEQELYdlKEEYDRVEKELSKLQRE----LAEAEAQARASEER 505
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 623-905 7.36e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 73.55  E-value: 7.36e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   623 ATENTQARVLHAEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSE 702
Cdd:TIGR02168  664 GSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE 743

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   703 QAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKK--SAQERCRA-EEEIDEIRKSYQEELDKLRQLL 779
Cdd:TIGR02168  744 QLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQieQLKEELKAlREALDELRAELTLLNEEAANLR 823

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   780 KKARVSTDQAAAEQLSLVqaELQTQWEAKCEHLLASAK---------DEHLLQYQEVCAQRDASQQELLRLQEKCLALQA 850
Cdd:TIGR02168  824 ERLESLERRIAATERRLE--DLEEQIEELSEDIESLAAeieeleeliEELESELEALLNERASLEEALALLRSELEELSE 901

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 961710477   851 QVTALTEQNEQHTKDLENKSHMsgVAAAATDpSEKVKKIMNQVFQSLRGEFELEE 905
Cdd:TIGR02168  902 ELRELESKRSELRRELEELREK--LAQLELR-LEGLEVRIDNLQERLSEEYSLTL 953
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
673-880 2.08e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 71.34  E-value: 2.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  673 LTESLKE--TDLLKGQLIKLQAELSELQETSEQAQSKfKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSE-RKKK 749
Cdd:COG4717    47 LLERLEKeaDELFKPQGRKPELNLKELKELEEELKEA-EEKEEEYAELQEELEELEEELEELEAELEELREELEKlEKLL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  750 SAQERCRAEEEIDEIRKSYQEELDKLRQllKKARVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDE---HLLQYQE 826
Cdd:COG4717   126 QLLPLYQELEALEAELAELPERLEELEE--RLEELRELEEELEELEAELAELQEELEELLEQLSLATEEElqdLAEELEE 203

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 961710477  827 VCAQRDASQQELLRLQEKCLALQAQVTALtEQNEQHTKDLENKSHMSGVAAAAT 880
Cdd:COG4717   204 LQQRLAELEEELEEAQEELEELEEELEQL-ENELEAAALEERLKEARLLLLIAA 256
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
626-866 2.74e-12

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 71.48  E-value: 2.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  626 NTQARVLHAEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQM-------------------QLTESLKETDLLKGQ 686
Cdd:COG4913   607 DNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeidvasaereiaELEAELERLDASSDD 686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  687 LIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRA---EEEIDE 763
Cdd:COG4913   687 LAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAalgDAVERE 766

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  764 IRKSYQEELDKLRQLLKKARvstdqaaaEQLSLVQAELQTQWEAKCEHLLASAKDEHllQYQEVCAQRDASqqELLRLQE 843
Cdd:COG4913   767 LRENLEERIDALRARLNRAE--------EELERAMRAFNREWPAETADLDADLESLP--EYLALLDRLEED--GLPEYEE 834

                         250       260
                  ....*....|....*....|...
gi 961710477  844 KCLALqaqvtaLTEQNEQHTKDL 866
Cdd:COG4913   835 RFKEL------LNENSIEFVADL 851
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 517-741 6.61e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.47  E-value: 6.61e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   517 TEIRMAVSKVADKMDHLMTKVEELQKhsagnslllpsmsvtmETSMIMGNIQRIIQENERLKQEILEKSSRIEEQNDKIS 596
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALAN----------------EISRLEQQKQILRERLANLERQLEELEAQLEELESKLD 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   597 ELIERNQRYVEQSNL--------------------MMEKRNNSLQTATENTQARVLHAEQEKAKVTEELTAATAQVSRLQ 656
Cdd:TIGR02168  334 ELAEELAELEEKLEElkeelesleaeleeleaeleELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLE 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   657 LKVTAHQKKEAELQMQLTEslKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEK 736
Cdd:TIGR02168  414 DRRERLQQEIEELLKKLEE--AELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARL 491


                   ....*
gi 961710477   737 ESLEK 741
Cdd:TIGR02168  492 DSLER 496
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 509-935 1.12e-11

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 69.37  E-value: 1.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   509 MTEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSLLLPSMSVTMET--SMIMGNIQRIIQENERLK---QEILE 583
Cdd:pfam05483  309 MSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSleELLRTEQQRLEKNEDQLKiitMELQK 388

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   584 KSSRIEE----QNDKISELIERNQRYVEQSNLMMEKRNnsLQTATENTQARvlhaEQEkakVTEELTAATAQVSRLQLKV 659
Cdd:pfam05483  389 KSSELEEmtkfKNNKEVELEELKKILAEDEKLLDEKKQ--FEKIAEELKGK----EQE---LIFLLQAREKEIHDLEIQL 459

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   660 TA-------HQKKEAELQMQL-TESLKETDLlKGQLIKLQAELSEL-QETSE-------QAQSKFKSEKQSRRQLElKVT 723
Cdd:pfam05483  460 TAiktseehYLKEVEDLKTELeKEKLKNIEL-TAHCDKLLLENKELtQEASDmtlelkkHQEDIINCKKQEERMLK-QIE 537

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   724 SLEEELADLRAEKESLEKnlsERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLK--------KARVSTDQAAAEQLS 795
Cdd:pfam05483  538 NLEEKEMNLRDELESVRE---EFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKIlenkcnnlKKQIENKNKNIEELH 614

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   796 LVQAELQTQWEAKCEHL-------------LASAK---DEHLLQYQEVCAQRDASQQELLRLQEKclalqAQVTALTEQN 859
Cdd:pfam05483  615 QENKALKKKGSAENKQLnayeikvnkleleLASAKqkfEEIIDNYQKEIEDKKISEEKLLEEVEK-----AKAIADEAVK 689

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   860 EQHTKDLENKSHMSGVAAAAtdpsEKVKKIMNQVFQSLRGEFEL-----EESYNGRAVLGTIMNTIKMVTLQLLNQHEQD 934
Cdd:pfam05483  690 LQKEIDKRCQHKIAEMVALM----EKHKHQYDKIIEERDSELGLyknkeQEQSSAKAALEIELSNIKAELLSLKKQLEIE 765


                   .
gi 961710477   935 K 935
Cdd:pfam05483  766 K 766
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
568-860 1.88e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 68.26  E-value: 1.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  568 QRIIQENERLK------QEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKV 641
Cdd:COG4717   139 AELAELPERLEeleerlEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEA 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  642 TEELTAATAQVSRLQLKVTAHQKKE--AELQMQL------------TESLKETDLLKGQLIKLQAELSELQETSEQAQSK 707
Cdd:COG4717   219 QEELEELEEELEQLENELEAAALEErlKEARLLLliaaallallglGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKA 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  708 FKSEKQSRRQLELKVTSLE-EELADLRAE---KESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEE--LDKLRQLLKK 781
Cdd:COG4717   299 SLGKEAEELQALPALEELEeEELEELLAAlglPPDLSPEELLELLDRIEELQELLREAEELEEELQLEelEQEIAALLAE 378

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  782 ARVSTD-------------QAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLAL 848
Cdd:COG4717   379 AGVEDEeelraaleqaeeyQELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAEL 458

                         330
                  ....*....|..
gi 961710477  849 QAQVTALTEQNE 860
Cdd:COG4717   459 EAELEQLEEDGE 470
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
508-782 6.42e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 67.01  E-value: 6.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  508 LMTEARQHNTEIRMaVSKVADKMDHLMTKVEELQKhsagnslllpsmsvtmETSMIMGNIQRI---IQENERLKQEILEK 584
Cdd:PRK03918  212 ISSELPELREELEK-LEKEVKELEELKEEIEELEK----------------ELESLEGSKRKLeekIRELEERIEELKKE 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  585 SSRIEEQNDKISELIERNQRYVEQSNLM---------MEKRNNSLQTATENTQARVLHAEQEKAKVtEELTaataqvsrl 655
Cdd:PRK03918  275 IEELEEKVKELKELKEKAEEYIKLSEFYeeyldelreIEKRLSRLEEEINGIEERIKELEEKEERL-EELK--------- 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  656 qlkvtahqKKEAELQ---MQLTESLKETDL---LKGQLIKLQAELSELqeTSEQAQSKFKSEKQSRRQLELKVTSLEEEL 729
Cdd:PRK03918  345 --------KKLKELEkrlEELEERHELYEEakaKKEELERLKKRLTGL--TPEKLEKELEELEKAKEEIEEEISKITARI 414

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 961710477  730 ADLRAEKESLEKNLSERKKksAQERCR------AEEEIDEIRKSYQEELDKLRQLLKKA 782
Cdd:PRK03918  415 GELKKEIKELKKAIEELKK--AKGKCPvcgrelTEEHRKELLEEYTAELKRIEKELKEI 471
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
575-802 1.21e-10

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 64.92  E-value: 1.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  575 ERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTAT---ENTQARVLHAEQEKAKVTEELTAATAQ 651
Cdd:COG4372     2 DRLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLReelEQAREELEQLEEELEQARSELEQLEEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  652 VSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELAD 731
Cdd:COG4372    82 LEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLES 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 961710477  732 LRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQ 802
Cdd:COG4372   162 LQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLG 232
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
563-801 1.45e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 65.71  E-value: 1.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  563 IMGNIQRIIQENERLKqEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRnnslqtaTENTQARVLHAEQEKAKVT 642
Cdd:COG4913   223 TFEAADALVEHFDDLE-RAHEALEDAREQIELLEPIRELAERYAAARERLAELE-------YLRAALRLWFAQRRLELLE 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  643 EELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIK-LQAELSELQETSEQAQSKFKSEKQSRRQLELK 721
Cdd:COG4913   295 AELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEqLEREIERLERELEERERRRARLEALLAALGLP 374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  722 VTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLlkKARVST----DQAA----AEQ 793
Cdd:COG4913   375 LPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASL--ERRKSNiparLLALrdalAEA 452


                  ....*...
gi 961710477  794 LSLVQAEL 801
Cdd:COG4913   453 LGLDEAEL 460
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 506-778 1.82e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 65.47  E-value: 1.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   506 SFLMTEARqhntEIRMAVSKVADKMDHLMTKVEELQKHsaGNSLLLPSMSVTMETSMIMGNIQRIIQENERLKQEILEKS 585
Cdd:TIGR02169  691 SSLQSELR----RIENRLDELSQELSDASRKIGEIEKE--IEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELE 764

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   586 SRIEEQNDKISEL------IER--NQRYVEQSNLMMEKRNN---SLQTATENTQARVLHAEQEKAKVTEELTAATAQVSR 654
Cdd:TIGR02169  765 ARIEELEEDLHKLeealndLEArlSHSRIPEIQAELSKLEEevsRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRID 844

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   655 LQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRA 734
Cdd:TIGR02169  845 LKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKA 924

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 961710477   735 EKESLEKNLS--ERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQL 778
Cdd:TIGR02169  925 KLEALEEELSeiEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRAL 970
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 579-806 2.66e-10

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 65.20  E-value: 2.66e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   579 QEILEK-SSRIEEQNDKIsELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKvteeltaATAQVSRLQL 657
Cdd:pfam01576  348 QEMRQKhTQALEELTEQL-EQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKK-------LEGQLQELQA 419

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   658 KVTAHQKKEAELQMQLTESLKETDLL-------KGQLIKLQAEL----SELQETSE--QAQSKFKSEKQSR-RQLELKVT 723
Cdd:pfam01576  420 RLSESERQRAELAEKLSKLQSELESVssllneaEGKNIKLSKDVssleSQLQDTQEllQEETRQKLNLSTRlRQLEDERN 499

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   724 SLEEELADLRAEKESLEKN-------LSERKKKsAQERCRAEEEIDEIRKSYQEELDKLRQLLKKarvstDQAAAEQLSL 796
Cdd:pfam01576  500 SLQEQLEEEEEAKRNVERQlstlqaqLSDMKKK-LEEDAGTLEALEEGKKRLQRELEALTQQLEE-----KAAAYDKLEK 573

                          250
                   ....*....|
gi 961710477   797 VQAELQTQWE 806
Cdd:pfam01576  574 TKNRLQQELD 583
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 635-856 5.65e-10

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 64.04  E-value: 5.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   635 EQEKAK--VTEELTAATAQVSRLQLKVT----AHQKKEAELQMQLT----ESLKETDLLKgQLIKLQAELSELQETSEqa 704
Cdd:pfam01576  205 ELEKAKrkLEGESTDLQEQIAELQAQIAelraQLAKKEEELQAALArleeETAQKNNALK-KIRELEAQISELQEDLE-- 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   705 qskfkSEKQSRRQLELKVTSLEEELADLRAEKESL--------------EKNLSERKKKSAQERCRAEEEIDEIRKSYQE 770
Cdd:pfam01576  282 -----SERAARNKAEKQRRDLGEELEALKTELEDTldttaaqqelrskrEQEVTELKKALEEETRSHEAQLQEMRQKHTQ 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   771 ELDKLRQLL---KKARVS---TDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHllQYQEVCAQRDASQQELLRLQEK 844
Cdd:pfam01576  357 ALEELTEQLeqaKRNKANlekAKQALESENAELQAELRTLQQAKQDSEHKRKKLEG--QLQELQARLSESERQRAELAEK 434

                          250
                   ....*....|..
gi 961710477   845 CLALQAQVTALT 856
Cdd:pfam01576  435 LSKLQSELESVS 446
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 655-861 6.21e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 62.47  E-value: 6.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  655 LQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRA 734
Cdd:COG4942    11 LALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  735 EKESLEKNLSERKK------------------------KSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAA 790
Cdd:COG4942    91 EIAELRAELEAQKEelaellralyrlgrqpplalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELE 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 961710477  791 AE--QLSLVQAELQTQWEAkcehlLASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQNEQ 861
Cdd:COG4942   171 AEraELEALLAELEEERAA-----LEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 566-781 6.89e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 63.50  E-value: 6.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   566 NIQRIIQENERLKQEILEKSSRIEEQNDKISELIER------------NQRYVEQSNL-MMEKRNNSLQTATENTQARVL 632
Cdd:TIGR04523  413 QIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQdsvkeliiknldNTRESLETQLkVLSRSINKIKQNLEQKQKELK 492

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   633 HAEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTE-----SLKETDL-----------LKGQLIKLQAELSE 696
Cdd:TIGR04523  493 SKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEkeskiSDLEDELnkddfelkkenLEKEIDEKNKEIEE 572

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   697 LQET---SEQAQSKFK-------SEKQS-RRQLELK---VTSLEEELADLRAEKESLE---KNLSERKKKSAQERCRAEE 759
Cdd:TIGR04523  573 LKQTqksLKKKQEEKQelidqkeKEKKDlIKEIEEKekkISSLEKELEKAKKENEKLSsiiKNIKSKKNKLKQEVKQIKE 652

                          250       260
                   ....*....|....*....|..
gi 961710477   760 EIDEIRKSYQEELDKLRQLLKK 781
Cdd:TIGR04523  653 TIKEIRNKWPEIIKKIKESKTK 674
PTZ00121 PTZ00121
MAEBL; Provisional
 573-888 9.97e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 63.24  E-value: 9.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  573 ENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKvTEELTAATaQV 652
Cdd:PTZ00121 1480 EEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKK-ADELKKAE-EL 1557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  653 SRLQLKVTAHQKKEAE----LQMQLTESLK--------ETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLEL 720
Cdd:PTZ00121 1558 KKAEEKKKAEEAKKAEedknMALRKAEEAKkaeearieEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQ 1637

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  721 KVTSLEEEladlRAEKESLEKNLSERKKKSAQERCRAEEE---IDEIRKSYQEELDKLRQLLKKARvstDQAAAEQLSLV 797
Cdd:PTZ00121 1638 LKKKEAEE----KKKAEELKKAEEENKIKAAEEAKKAEEDkkkAEEAKKAEEDEKKAAEALKKEAE---EAKKAEELKKK 1710

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  798 QAElqtqwEAKCEHLLASAKDEHLLQYQEvcAQRDASqqellrlQEKCLALQAQVTALTEQNEQHTKDLENKSHMSGVAA 877
Cdd:PTZ00121 1711 EAE-----EKKKAEELKKAEEENKIKAEE--AKKEAE-------EDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKE 1776

                         330
                  ....*....|.
gi 961710477  878 AATDPSEKVKK 888
Cdd:PTZ00121 1777 KEAVIEEELDE 1787
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 660-832 1.03e-09

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 60.32  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  660 TAHQKKEAELQMQLTESlkETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESL 739
Cdd:COG1579     1 AMPEDLRALLDLQELDS--ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  740 EKNLSE-------------------RKKKSAQERCRAEEEIDEIRKSY---QEELDKLRQLLKKARVSTDQAAAEqlslV 797
Cdd:COG1579    79 EEQLGNvrnnkeyealqkeieslkrRISDLEDEILELMERIEELEEELaelEAELAELEAELEEKKAELDEELAE----L 154

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 961710477  798 QAELQTQwEAKCEHLLASAKDEHLLQYQEVCAQRD 832
Cdd:COG1579   155 EAELEEL-EAEREELAAKIPPELLALYERIRKRKN 188
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
636-807 1.24e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 62.48  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  636 QEKAKVTEELTAATAQVSRL--QLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFksekQ 713
Cdd:COG4717    81 KEAEEKEEEYAELQEELEELeeELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERL----E 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  714 SRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQ 793
Cdd:COG4717   157 ELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENEL 236

                         170
                  ....*....|....
gi 961710477  794 LSLVQAELQTQWEA 807
Cdd:COG4717   237 EAAALEERLKEARL 250
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 566-869 1.46e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 62.35  E-value: 1.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   566 NIQRIIQENERLKQEILEKSSRIE---EQNDKISELIERNQRYVEQSNLMMEKRNNSLQTAteNTQARVLHAEQEkakvt 642
Cdd:TIGR04523  233 NIEKKQQEINEKTTEISNTQTQLNqlkDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQL--KSEISDLNNQKE----- 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   643 EELTaataqvSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAEL-------SELQETSEQAQS---KFKSEK 712
Cdd:TIGR04523  306 QDWN------KELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELtnsesenSEKQRELEEKQNeieKLKKEN 379

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   713 QSRRQ----LELKVTSLE--------------EELADLRAEKESLEK---NLSERKKKSAQERCRAEEEIDEIRKSYqEE 771
Cdd:TIGR04523  380 QSYKQeiknLESQINDLEskiqnqeklnqqkdEQIKKLQQEKELLEKeieRLKETIIKNNSEIKDLTNQDSVKELII-KN 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   772 LDKLRQLLKKarvstdqaaaeQLSLVQAE---LQTQWEAKCEHLlaSAKDEHLLQYQEVCAQRDASQQELLRLQEKCLAL 848
Cdd:TIGR04523  459 LDNTRESLET-----------QLKVLSRSinkIKQNLEQKQKEL--KSKEKELKKLNEEKKELEEKVKDLTKKISSLKEK 525

                          330       340
                   ....*....|....*....|.
gi 961710477   849 QAQVTALTEQNEQHTKDLENK 869
Cdd:TIGR04523  526 IEKLESEKKEKESKISDLEDE 546
DUF4686 pfam15742
Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins ...
 600-863 1.52e-09

Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins in this family are typically between 498 and 775 amino acids in length. There is a conserved DLK sequence motif.


Pssm-ID: 464838 [Multi-domain]  Cd Length: 384  Bit Score: 61.23  E-value: 1.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   600 ERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELTAATAQVSRLQLKVtahqkKEAELQM-QLTESLK 678
Cdd:pfam15742   33 EKELRYERGKNLDLKQHNSLLQEENIKIKAELKQAQQKLLDSTKMCSSLTAEWKHCQQKI-----RELELEVlKQAQSIK 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   679 ETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRrqlelkvtsleeeLADLRAekesLEKNLSERKKKSAQErcrae 758
Cdd:pfam15742  108 SQNSLQEKLAQEKSRVADAEEKILELQQKLEHAHKVC-------------LTDTCI----LEKKQLEERIKEASE----- 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   759 eEIDEIRKSYQEE------LDKLRQLLKKaRVSTDQAAAEQLSLVQAELQT---QWEAKCEHLLA--SAKDEHLLQYQEV 827
Cdd:pfam15742  166 -NEAKLKQQYQEEqqkrklLDQNVNELQQ-QVRSLQDKEAQLEMTNSQQQLriqQQEAQLKQLENekRKSDEHLKSNQEL 243

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 961710477   828 CAQRDASQQELLRLQEKCLALQAQVTA-LTEQNEQHT 863
Cdd:pfam15742  244 SEKLSSLQQEKEALQEELQQVLKQLDVhVRKYNEKHH 280
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 567-820 2.14e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 61.96  E-value: 2.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   567 IQRIIQENERLKQEILEKSSRIEEQNDKISEliernqryveqsnlmMEKRNNSLQTATENTQARVLHAEQEKAKVTEELT 646
Cdd:TIGR04523  372 IEKLKKENQSYKQEIKNLESQINDLESKIQN---------------QEKLNQQKDEQIKKLQQEKELLEKEIERLKETII 436

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   647 AATAQVSRLQLKVTAHQKKEAELQmQLTESLKE-TDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSL 725
Cdd:TIGR04523  437 KNNSEIKDLTNQDSVKELIIKNLD-NTRESLETqLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDL 515

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   726 EEELA-------DLRAEKESLEKNLSERKKK-----SAQERCRAEEEIDEirksYQEELDKLRQ----LLKK---ARVST 786
Cdd:TIGR04523  516 TKKISslkekieKLESEKKEKESKISDLEDElnkddFELKKENLEKEIDE----KNKEIEELKQtqksLKKKqeeKQELI 591

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 961710477   787 DQAAAEQLSLV-QAELQTQWEAKCEHLLASAKDEH 820
Cdd:TIGR04523  592 DQKEKEKKDLIkEIEEKEKKISSLEKELEKAKKEN 626
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 567-746 4.34e-09

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 58.40  E-value: 4.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  567 IQRIIQENERLKQEILEKSSRIEEQNDKISELIErnqryvEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELT 646
Cdd:COG1579    19 LDRLEHRLKELPAELAELEDELAALEARLEAAKT------ELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKEYE 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  647 AATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQEtseqaqskfksekqsrrQLELKVTSLE 726
Cdd:COG1579    93 ALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKA-----------------ELDEELAELE 155

                         170       180
                  ....*....|....*....|
gi 961710477  727 EELADLRAEKESLEKNLSER 746
Cdd:COG1579   156 AELEELEAEREELAAKIPPE 175
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 566-869 4.53e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 60.80  E-value: 4.53e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   566 NIQRIIQENERLK----QEILEKSSRIEEQNDKISELIERNQRYveqsnlmmEKRNNSLqtatentqarvlhaEQEKAKV 641
Cdd:TIGR04523  128 KLEKQKKENKKNIdkflTEIKKKEKELEKLNNKYNDLKKQKEEL--------ENELNLL--------------EKEKLNI 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   642 TEELTAATAQVSRLQLKVTAHQKKEA---ELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQS---- 714
Cdd:TIGR04523  186 QKNIDKIKNKLLKLELLLSNLKKKIQknkSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEqnki 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   715 -----RRQLEL-----KVTSLEE-------ELADLRAEKES-LEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLR 776
Cdd:TIGR04523  266 kkqlsEKQKELeqnnkKIKELEKqlnqlksEISDLNNQKEQdWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQIS 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   777 QLLK--KARVSTDQAAAEQLSLVQAELQT---QWEAKCEHL--LASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQ 849
Cdd:TIGR04523  346 QLKKelTNSESENSEKQRELEEKQNEIEKlkkENQSYKQEIknLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLE 425

                          330       340
                   ....*....|....*....|...
gi 961710477   850 AQVTALTEQNEQHT---KDLENK 869
Cdd:TIGR04523  426 KEIERLKETIIKNNseiKDLTNQ 448
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 571-871 4.74e-09

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 60.36  E-value: 4.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  571 IQENERLKQEILEKSSRIEEQNDKISELIERNQRYVE----QSNLMMEKRN---NSLQTATENTQARVLHAEQE--KAKV 641
Cdd:COG5185   231 IEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLeklgENAESSKRLNenaNNLIKQFENTKEKIAEYTKSidIKKA 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  642 TEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQS--KFKSEKQsrrQLE 719
Cdd:COG5185   311 TESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELSKSseELDSFKD---TIE 387

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  720 LKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKkarvSTDQAAAEQLSLVQA 799
Cdd:COG5185   388 STKESLDEIPQNQRGYAQEILATLEDTLKAADRQIEELQRQIEQATSSNEEVSKLLNELIS----ELNKVMREADEESQS 463

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 961710477  800 ELQtqweakcehllaSAKDEHllqYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQNEQHTKDLENKSH 871
Cdd:COG5185   464 RLE------------EAYDEI---NRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLD 520
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
643-842 5.02e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 60.70  E-value: 5.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  643 EELTAATAQVSRLQLKVTAHQK-KEAELQMQLTESLKET----------DLLKGQLIKLQAELSELQETSEQAQSKFKSE 711
Cdd:COG4913   242 EALEDAREQIELLEPIRELAERyAAARERLAELEYLRAAlrlwfaqrrlELLEAELEELRAELARLEAELERLEARLDAL 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  712 KQSRRQLELKVTSLE-EELADLRAEKESLEKNLSERKKKSAQercraeeeideirksYQEELDKLrqllkKARVSTDQAA 790
Cdd:COG4913   322 REELDELEAQIRGNGgDRLEQLEREIERLERELEERERRRAR---------------LEALLAAL-----GLPLPASAEE 381

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 961710477  791 AEQLSLVQAELQTQWEAKcEHLLASAKDEHLLQYQEVCAQRDASQQELLRLQ 842
Cdd:COG4913   382 FAALRAEAAALLEALEEE-LEALEEALAEAEAALRDLRRELRELEAEIASLE 432
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 578-864 6.96e-09

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 60.35  E-value: 6.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  578 KQEILEKSSRIEEQNDKISELIERnQRYVEQSNLMMEKRNNSLQTATentqarvlhAEQEK-AKVTEELTAATAQVSRLQ 656
Cdd:COG3096   298 RRQLAEEQYRLVEMARELEELSAR-ESDLEQDYQAASDHLNLVQTAL---------RQQEKiERYQEDLEELTERLEEQE 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  657 LKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQL---ELKVTSLEEELADLR 733
Cdd:COG3096   368 EVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAVQALEKARALCglpDLTPENAEDYLAAFR 447

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  734 AEKESLEKNLSERKKKSAQercrAEEEIDEIRKSYQ------------EELDKLRQLLKKARVSTDQAA----------- 790
Cdd:COG3096   448 AKEQQATEEVLELEQKLSV----ADAARRQFEKAYElvckiageversQAWQTARELLRRYRSQQALAQrlqqlraqlae 523

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 961710477  791 AEQLSLVQAELQTQWEAKCEHL---LASAKD-EHLLQYQEvcAQRDASQQELLRLQEKCLALQAQVTALTEQNEQHTK 864
Cdd:COG3096   524 LEQRLRQQQNAERLLEEFCQRIgqqLDAAEElEELLAELE--AQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAA 599
PTZ00121 PTZ00121
MAEBL; Provisional
 575-870 7.06e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.54  E-value: 7.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  575 ERLKQEILEKSSRIEEQNDKiseliernqRYVEQSNLMMEKRNNSLQTATENTQArvlhaeqEKAKVTEELtaataQVSR 654
Cdd:PTZ00121 1544 EKKKADELKKAEELKKAEEK---------KKAEEAKKAEEDKNMALRKAEEAKKA-------EEARIEEVM-----KLYE 1602

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  655 LQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQ------------AQSKFKSEKQSRRQLELKV 722
Cdd:PTZ00121 1603 EEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEElkkaeeenkikaAEEAKKAEEDKKKAEEAKK 1682

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  723 TSLEEELADLRAEKESLEKNLSER-KKKSAQERCRAEeeidEIRKSYQEELDKLRQLLKKARvsTDQAAAEQLSLVQAEl 801
Cdd:PTZ00121 1683 AEEDEKKAAEALKKEAEEAKKAEElKKKEAEEKKKAE----ELKKAEEENKIKAEEAKKEAE--EDKKKAEEAKKDEEE- 1755

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 961710477  802 qtqwEAKCEHLlasaKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAqvtalteqnEQHTKDLENKS 870
Cdd:PTZ00121 1756 ----KKKIAHL----KKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEV---------DKKIKDIFDNF 1807
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
564-901 7.95e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 60.08  E-value: 7.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  564 MGNIQRIIQENERLKQEILEKSSRIEEQNDKISEL---IERNQRYVEQSNLMMEKRNNSLQTATENT-------QARVLH 633
Cdd:PRK03918  316 LSRLEEEINGIEERIKELEEKEERLEELKKKLKELekrLEELEERHELYEEAKAKKEELERLKKRLTgltpeklEKELEE 395

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  634 AEQEKAKVTEELTAATAQVSRL------------QLK------------VTAHQKKE--AELQMQLTESLKETDLLKGQL 687
Cdd:PRK03918  396 LEKAKEEIEEEISKITARIGELkkeikelkkaieELKkakgkcpvcgreLTEEHRKEllEEYTAELKRIEKELKEIEEKE 475

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  688 IKLQAELSELqETSEQAQSKFKSEKQSRRQL-----ELKVTSLE-------------EELADLRAEKESLEKNLS----- 744
Cdd:PRK03918  476 RKLRKELREL-EKVLKKESELIKLKELAEQLkeleeKLKKYNLEelekkaeeyeklkEKLIKLKGEIKSLKKELEkleel 554

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  745 -------ERKKKSAQERCRA----------------EEEIDEIRKSYQE---------ELDKLRQLLKKARVSTDQAAAE 792
Cdd:PRK03918  555 kkklaelEKKLDELEEELAEllkeleelgfesveelEERLKELEPFYNEylelkdaekELEREEKELKKLEEELDKAFEE 634

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  793 qLSLVQAELQtQWEAKCEHLLASAKDEhllQYQEVcaqrdasQQELLRLQEKCLALQAQVTALTEQNEQHTKDLENKSHM 872
Cdd:PRK03918  635 -LAETEKRLE-ELRKELEELEKKYSEE---EYEEL-------REEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEE 702

                         410       420
                  ....*....|....*....|....*....
gi 961710477  873 SGVAAAATDPSEKVKKIMNQVfQSLRGEF 901
Cdd:PRK03918  703 LEEREKAKKELEKLEKALERV-EELREKV 730
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
555-793 8.02e-09

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 58.38  E-value: 8.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  555 SVTMETSMIMGNIQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHA 634
Cdd:COG1340     5 ELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  635 EQ--EKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQ-MQLTESL---KETDL------LKGQLIKLQAEL---SELQE 699
Cdd:COG1340    85 EKlnELREELDELRKELAELNKAGGSIDKLRKEIERLEwRQQTEVLspeEEKELvekikeLEKELEKAKKALeknEKLKE 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  700 TSEQAQSKFKSEKQSRRQLE----------LKVTSLEEELADLRAEKESLEKNLSERKKKSAQERcraeEEIDEIRKS-- 767
Cdd:COG1340   165 LRAELKELRKEAEEIHKKIKelaeeaqelhEEMIELYKEADELRKEADELHKEIVEAQEKADELH----EEIIELQKElr 240

                         250       260
                  ....*....|....*....|....*..
gi 961710477  768 -YQEELDKLRQLLKKARVSTDQAAAEQ 793
Cdd:COG1340   241 eLRKELKKLRKKQRALKREKEKEELEE 267
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
565-781 8.59e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 60.08  E-value: 8.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  565 GNIQRIIQENE----RLKQEILEKSSRIEEQNDKISELIERNQRY------VEQSNLMMEKRNNSLQTATE---NTQARV 631
Cdd:PRK03918  189 ENIEELIKEKEkeleEVLREINEISSELPELREELEKLEKEVKELeelkeeIEELEKELESLEGSKRKLEEkirELEERI 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  632 lhaeQEKAKVTEELTAATAQVSRLQLKVTAHQKKEaELQMQLTESLKETDLLKG---QLIK-LQAELSELQETSEQAQSK 707
Cdd:PRK03918  269 ----EELKKEIEELEEKVKELKELKEKAEEYIKLS-EFYEEYLDELREIEKRLSrleEEINgIEERIKELEEKEERLEEL 343

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 961710477  708 FKSEKQSRRQLElKVTSLEEELADLRAEKESLEKnlsERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKK 781
Cdd:PRK03918  344 KKKLKELEKRLE-ELEERHELYEEAKAKKEELER---LKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITAR 413
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 572-913 9.96e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 59.99  E-value: 9.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   572 QENERLKQEILEKS--SRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENtqarvLHAEQEKAKVTEELTaaT 649
Cdd:pfam02463  649 RKGVSLEEGLAEKSevKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKE-----QREKEELKKLKLEAE--E 721

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   650 AQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSE-LQETSEQAQSKFKSEKQS-RRQLELKVTSLEE 727
Cdd:pfam02463  722 LLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSElSLKEKELAEEREKTEKLKvEEEKEEKLKAQEE 801

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   728 ELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDklRQLLKKARVSTDQAAAEQLSLVQAELQTQWEA 807
Cdd:pfam02463  802 ELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQK--LEKLAEEELERLEEEITKEELLQELLLKEEEL 879

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   808 KCEHLLASAKDEHLLQYQEvcaqrdasQQELLRLQEKCLALQAQVTALTEQNEQHTKDLENKS----HMSGVAAAATDPS 883
Cdd:pfam02463  880 EEQKLKDELESKEEKEKEE--------KKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEeepeELLLEEADEKEKE 951

                          330       340       350
                   ....*....|....*....|....*....|
gi 961710477   884 EKVKKIMNQVFQSLRGEFELEESYNGRAVL 913
Cdd:pfam02463  952 ENNKEEEEERNKRLLLAKEELGKVNLMAIE 981
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 614-777 1.26e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 56.86  E-value: 1.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  614 EKRNNSLQTATENTQARVLHAEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTES---------LKETDLLK 684
Cdd:COG1579    23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVrnnkeyealQKEIESLK 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  685 GQLIKLQAELSELQETSEQAQSKFKsekqsrrQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDE- 763
Cdd:COG1579   103 RRISDLEDEILELMERIEELEEELA-------ELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKIPPe 175

                         170
                  ....*....|....
gi 961710477  764 IRKSYqeelDKLRQ 777
Cdd:COG1579   176 LLALY----ERIRK 185
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
566-808 1.39e-08

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 58.38  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  566 NIQRIIQENERLKQEILEKSSRIEEQNDKISEL---IERNQRYVEQSNLMMEKRNNSLQTATENTQArvlhAEQEKAKVT 642
Cdd:COG4372    39 ELDKLQEELEQLREELEQAREELEQLEEELEQArseLEQLEEELEELNEQLQAAQAELAQAQEELES----LQEEAEELQ 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  643 EELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSE-----QAQSKFKSEKQSRRQ 717
Cdd:COG4372   115 EELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQalseaEAEQALDELLKEANR 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  718 LELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLV 797
Cdd:COG4372   195 NAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTE 274

                         250
                  ....*....|.
gi 961710477  798 QAELQTQWEAK 808
Cdd:COG4372   275 EEELEIAALEL 285
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
567-778 1.46e-08

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 59.26  E-value: 1.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  567 IQRIIQENERLKQEILEKSSR-IEEQNDKISELIERNQRYVEQsnlmMEKRNNSLQTATENTQArvlhaEQEKAKVTEEL 645
Cdd:COG3206   158 AEAYLEQNLELRREEARKALEfLEEQLPELRKELEEAEAALEE----FRQKNGLVDLSEEAKLL-----LQQLSELESQL 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  646 TAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDL--LKGQLIKLQAELSELQETS-------EQAQSKFKS-EKQSR 715
Cdd:COG3206   229 AEARAELAEAEARLAALRAQLGSGPDALPELLQSPVIqqLRAQLAELEAELAELSARYtpnhpdvIALRAQIAAlRAQLQ 308

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 961710477  716 RQLELKVTSLEEELADLRAEKESLEKNLSERKKKSA------QERCRAEEEIDEIRKSYQEELDKLRQL 778
Cdd:COG3206   309 QEAQRILASLEAELEALQAREASLQAQLAQLEARLAelpeleAELRRLEREVEVARELYESLLQRLEEA 377
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
582-870 1.65e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.92  E-value: 1.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  582 LEKSSRIEEQNDKISELIER--------NQRYVEQ--------SNLMMEK------RNNSLQTATENTQaRVLHAEQEKA 639
Cdd:PRK03918  100 LDGSEVLEEGDSSVREWVERlipyhvflNAIYIRQgeidaileSDESREKvvrqilGLDDYENAYKNLG-EVIKEIKRRI 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  640 KVTEELTAATAQVSRLqlkvtahqKKEAElqMQLTESLKETDLLKGQLIKLQAELS----------ELQETSEQAQSKFK 709
Cdd:PRK03918  179 ERLEKFIKRTENIEEL--------IKEKE--KELEEVLREINEISSELPELREELEklekevkeleELKEEIEELEKELE 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  710 SEKQSRRQLELKVTSLEEELADLRAEKESLEKNlsERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKARvstdqa 789
Cdd:PRK03918  249 SLEGSKRKLEEKIRELEERIEELKKEIEELEEK--VKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLE------ 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  790 aaEQLSLVQAELQTqweakcehllASAKDEHLlqyQEVCAQRDASQQELLRLQEKCLALQaQVTALTEQNEQHTKDLENK 869
Cdd:PRK03918  321 --EEINGIEERIKE----------LEEKEERL---EELKKKLKELEKRLEELEERHELYE-EAKAKKEELERLKKRLTGL 384


                  .
gi 961710477  870 S 870
Cdd:PRK03918  385 T 385
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 567-805 2.75e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.47  E-value: 2.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  567 IQRIIQENER----LKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLmMEKRNNSLQTATENTQARVlhaEQEKAKVT 642
Cdd:COG4942    32 LQQEIAELEKelaaLKKEEKALLKQLAALERRIAALARRIRALEQELAA-LEAELAELEKEIAELRAEL---EAQKEELA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  643 EELTAA--TAQVSRLQLKVTAHQKKEAELQMQLTESLKETDllKGQLIKLQAELSELQETseqaqskfksekqsRRQLEL 720
Cdd:COG4942   108 ELLRALyrLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPAR--REQAEELRADLAELAAL--------------RAELEA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  721 KVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEElDKLRQLLKKARVSTDQAAAEQLSLVQAE 800
Cdd:COG4942   172 ERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEA-EELEALIARLEAEAAAAAERTPAAGFAA 250


                  ....*
gi 961710477  801 LQTQW 805
Cdd:COG4942   251 LKGKL 255
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
566-789 3.46e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.15  E-value: 3.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  566 NIQRIIQENERLKQEILEKSSRIEEQNDKISELiernqryveqsnlmmEKRNNSLQTATENTQARVLHAEQEKAKVTEel 645
Cdd:PRK03918  180 RLEKFIKRTENIEELIKEKEKELEEVLREINEI---------------SSELPELREELEKLEKEVKELEELKEEIEE-- 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  646 taataqVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQ--AQSKFKSEKQSRRQlelkvt 723
Cdd:PRK03918  243 ------LEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEyiKLSEFYEEYLDELR------ 310

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 961710477  724 SLEEELADLRAEKESLEKNLSERKKKSAQERcRAEEEIDEIRKSYqEELDKLRQLLKKARVSTDQA 789
Cdd:PRK03918  311 EIEKRLSRLEEEINGIEERIKELEEKEERLE-ELKKKLKELEKRL-EELEERHELYEEAKAKKEEL 374
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
 568-864 5.88e-08

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 57.22  E-value: 5.88e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   568 QRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQsnlmMEKRNNSLQTATENTQARVLHAEQEKAKVTEELta 647
Cdd:pfam15964  381 EKRAQEKEALRKEMKKEREELGATMLALSQNVAQLEAQVEK----VTREKNSLVSQLEEAQKQLASQEMDVTKVCGEM-- 454

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   648 ataqvsRLQLKVTAHQKKEAELQMQ--LTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSL 725
Cdd:pfam15964  455 ------RYQLNQTKMKKDEAEKEHReyRTKTGRQLEIKDQEIEKLGLELSESKQRLEQAQQDAARAREECLKLTELLGES 528

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   726 EEELADLRAEKESLEKNLSERKKKSAQERCRAEEEideirksyqeeldkLRQLLKKARVSTDQAAAEQLSLV--QAELQT 803
Cdd:pfam15964  529 EHQLHLTRLEKESIQQSFSNEAKAQALQAQQREQE--------------LTQKMQQMEAQHDKTVNEQYSLLtsQNTFIA 594

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 961710477   804 QWEAKCeHLLASAKDEHLLQYQEVCAQRDasqQELLRLQEKCLALQAQVTALTEQNEQHTK 864
Cdd:pfam15964  595 KLKEEC-CTLAKKLEEITQKSRSEVEQLS---QEKEYLQDRLEKLQKRNEELEEQCVQHGR 651
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 567-783 5.95e-08

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 57.29  E-value: 5.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   567 IQRIIQENERLKQEILEKSSRIEEQNDKISELIERnqryvEQSNLMMEKRNNSLQTATENTQARVLHAEQ--EKAKVTEE 644
Cdd:pfam02463  814 AELLEEEQLLIEQEEKIKEEELEELALELKEEQKL-----EKLAEEELERLEEEITKEELLQELLLKEEEleEQKLKDEL 888

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   645 LTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIK--LQAELSELQETSEQAQ-SKFKSEKQSRRQLELK 721
Cdd:pfam02463  889 ESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYeeEPEELLLEEADEKEKEeNNKEEEEERNKRLLLA 968

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 961710477   722 VTSLEEELADLRAEKESLEknlsERKKKSAQERCRAEEEIDEIRksyQEELDKLRQLLKKAR 783
Cdd:pfam02463  969 KEELGKVNLMAIEEFEEKE----ERYNKDELEKERLEEEKKKLI---RAIIEETCQRLKEFL 1023
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
625-804 7.84e-08

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 56.56  E-value: 7.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  625 ENTQARVLHAEQEKAKVTEELTAATAQVSRLQLKVTAHQKKE--AELQMQLTESLKETDLLKGQLIKLQAELSELQETSE 702
Cdd:COG3206   164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNglVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLA 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  703 QAQSKFKSEKQSRRQL--ELKVTSLEEELADLRAEKESLEKNLSERkkksAQERCRAEEEIDEIRKSYQEELDKLRQLLK 780
Cdd:COG3206   244 ALRAQLGSGPDALPELlqSPVIQQLRAQLAELEAELAELSARYTPN----HPDVIALRAQIAALRAQLQQEAQRILASLE 319

                         170       180
                  ....*....|....*....|....
gi 961710477  781 KARvstdQAAAEQLSLVQAELQTQ 804
Cdd:COG3206   320 AEL----EALQAREASLQAQLAQL 339
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
575-765 9.22e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.31  E-value: 9.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  575 ERLKQEILEKSSRIEEQNDKISELIERNQRYVEqsnlmMEKRNNSLQTATENTQARVLHAEQEKA--KVTEELTAATAQV 652
Cdd:COG4717    67 ELNLKELKELEEELKEAEEKEEEYAELQEELEE-----LEEELEELEAELEELREELEKLEKLLQllPLYQELEALEAEL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  653 SRLQLKVTAHQKKEAELQmQLTESLKEtdlLKGQLIKLQAELSEL-QETSEQAQSKFKSEKQSRRQLELKVTSLEEELAD 731
Cdd:COG4717   142 AELPERLEELEERLEELR-ELEEELEE---LEAELAELQEELEELlEQLSLATEEELQDLAEELEELQQRLAELEEELEE 217

                         170       180       190
                  ....*....|....*....|....*....|....
gi 961710477  732 LRAEKESLEKNLSERKKKsaQERCRAEEEIDEIR 765
Cdd:COG4717   218 AQEELEELEEELEQLENE--LEAAALEERLKEAR 249
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 618-741 1.17e-07

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 51.87  E-value: 1.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   618 NSLQTATENTQARVLHAEQEKAKVTEELTAataQVSRLQlkvTAHQKKEAELQMQlTESLKETDLLKGQLIKLQAELSEL 697
Cdd:pfam07926    4 SSLQSEIKRLKEEAADAEAQLQKLQEDLEK---QAEIAR---EAQQNYERELVLH-AEDIKALQALREELNELKAEIAEL 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 961710477   698 QETSEQAQSKFKSEKQSrrqLELKVTSLEEELADLRAEKESLEK 741
Cdd:pfam07926   77 KAEAESAKAELEESEES---WEEQKKELEKELSELEKRIEDLNE 117
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
573-783 1.19e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.93  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  573 ENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLhaeqEKAKVT--EELTAATA 650
Cdd:COG4717   317 EEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALL----AEAGVEdeEELRAALE 392

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  651 QVSRLQlkvtAHQKKEAELQMQLTESLKE--TDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEE- 727
Cdd:COG4717   393 QAEEYQ----ELKEELEELEEQLEELLGEleELLEALDEEELEEELEELEEELEELEEELEELREELAELEAELEQLEEd 468

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 961710477  728 -ELADLRAEKESLEKNLSERKKKsAQERCRAEEEIDEIRKSYQEEldKLRQLLKKAR 783
Cdd:COG4717   469 gELAELLQELEELKAELRELAEE-WAALKLALELLEEAREEYREE--RLPPVLERAS 522
PTZ00121 PTZ00121
MAEBL; Provisional
 573-942 1.90e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.92  E-value: 1.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  573 ENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEeltaataqv 652
Cdd:PTZ00121 1312 EEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADA--------- 1382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  653 srlqLKVTAHQKKEA-ELQMQLTESLKETDLLKgqliKLQAELSELQETSEQAQSKFKSEK------QSRRQLELKVTSL 725
Cdd:PTZ00121 1383 ----AKKKAEEKKKAdEAKKKAEEDKKKADELK----KAAAAKKKADEAKKKAEEKKKADEakkkaeEAKKADEAKKKAE 1454

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  726 EEELADlRAEKESLEKNLSERKKKSAQERCRAEE--EIDEIRKSYQEELDKLRQLLKKA---RVSTDQAAAEQLSLVQAE 800
Cdd:PTZ00121 1455 EAKKAE-EAKKKAEEAKKADEAKKKAEEAKKADEakKKAEEAKKKADEAKKAAEAKKKAdeaKKAEEAKKADEAKKAEEA 1533

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  801 LQTQWEAKCEHLLAS---AKDEHLLQYQEVCA---QRDASQQELLRLQEKCLALQAQVTALTEQNEQHTKDLENKSHMSG 874
Cdd:PTZ00121 1534 KKADEAKKAEEKKKAdelKKAEELKKAEEKKKaeeAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAK 1613

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  875 VAAAATDPSEKVKKI--MNQVFQSLRGEFELEESYNGRAVLGTIMNTIKMVTLQLLNQHEQDKGQSSSEE 942
Cdd:PTZ00121 1614 KAEEAKIKAEELKKAeeEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKA 1683
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 191-309 2.14e-07

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 53.61  E-value: 2.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  191 GPAVEVGDSLEVAYTSWLLQnhvlGQVLDSTANKDKLLRLKLGSgkVIKAWEDGMLGMKKGGKRLLVIPPACAAGSEGVT 270
Cdd:PRK10902  158 GEAPKDSDTVVVNYKGTLID----GKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVP 231

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 961710477  271 GWtqSPDSILVYEVEMRRVKFARDSGSDGHSVSSRDSAA 309
Cdd:PRK10902  232 GI--PANSTLVFDVELLDVKPAPKADAKPEADAKAADSA 268
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 567-781 2.25e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.45  E-value: 2.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   567 IQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNnSLQTATENTQARVLHAEQEKAKVTEELT 646
Cdd:TIGR02168  840 LEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALA-LLRSELEELSEELRELESKRSELRRELE 918

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   647 AATAQVSRLQLKVTAHQKKEAELQMQLTESLK---------------ETDLLKGQLIKLQAELSELQETSEQAQSKFKSE 711
Cdd:TIGR02168  919 ELREKLAQLELRLEGLEVRIDNLQERLSEEYSltleeaealenkiedDEEEARRRLKRLENKIKELGPVNLAAIEEYEEL 998

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 961710477   712 KQsRRQLelkvtsLEEELADLRAEKESLEKnlserkkksaqercrAEEEID-EIRKSYQEELDKLRQLLKK 781
Cdd:TIGR02168  999 KE-RYDF------LTAQKEDLTEAKETLEE---------------AIEEIDrEARERFKDTFDQVNENFQR 1047
PTZ00121 PTZ00121
MAEBL; Provisional
 572-895 2.59e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 2.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  572 QENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRN--NSLQTATENTQARVLHAEQEKAKVTEELT--A 647
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKaeEAKKKAEEAKKADEAKKKAEEAKKADEAKkkA 1492

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  648 ATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSE-----------QAQSKFKSEKQSR- 715
Cdd:PTZ00121 1493 EEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKadelkkaeelkKAEEKKKAEEAKKa 1572

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  716 --------------RQLELK----VTSLEEELADLRAEK-----------ESLEKNLSERKKKSAQERCRAEE--EIDEI 764
Cdd:PTZ00121 1573 eedknmalrkaeeaKKAEEArieeVMKLYEEEKKMKAEEakkaeeakikaEELKKAEEEKKKVEQLKKKEAEEkkKAEEL 1652

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  765 RKsyQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLLQYQEvcaqRDASQQELLRLQEK 844
Cdd:PTZ00121 1653 KK--AEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEA----EEKKKAEELKKAEE 1726

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 961710477  845 CLALQAQVTALTEQN-----EQHTKDLENKSHMSGVAAAATDPSEKVKKIMNQVFQ 895
Cdd:PTZ00121 1727 ENKIKAEEAKKEAEEdkkkaEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIE 1782
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 658-803 2.78e-07

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 52.22  E-value: 2.78e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   658 KVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQaqskFKSEKQSRRQLELKVTSLEEELADLRAEKE 737
Cdd:pfam13851   34 EIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLEN----YEKDKQSLKNLKARLKVLEKELKDLKWEHE 109

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 961710477   738 SLEknlsERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKaRVstdQAAAEQLSLVQAELQT 803
Cdd:pfam13851  110 VLE----QRFEKVERERDELYDKFEAAIQDVQQKTGLKNLLLEK-KL---QALGETLEKKEAQLNE 167
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 664-779 2.98e-07

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 50.72  E-value: 2.98e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   664 KKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSE--KQSR-----RQLELKVTSLEEELADLRAEK 736
Cdd:pfam07926    1 AELSSLQSEIKRLKEEAADAEAQLQKLQEDLEKQAEIAREAQQNYERElvLHAEdikalQALREELNELKAEIAELKAEA 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 961710477   737 ESLEKNLSERKKKSAQERCRAEEEIDEIRKSYqEELDKLRQLL 779
Cdd:pfam07926   81 ESAKAELEESEESWEEQKKELEKELSELEKRI-EDLNEQNKLL 122
PRK11281 PRK11281
mechanosensitive channel MscK;
566-805 3.03e-07

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 54.92  E-value: 3.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  566 NIQRIIQENERLKQEILEKSSRIEEQNDKISELIERN-----QRYVEQSNLMMEKRNNSLQTATENTQarvlhaeqekak 640
Cdd:PRK11281   74 KIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDNdeetrETLSTLSLRQLESRLAQTLDQLQNAQ------------ 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  641 vtEELTAATAQVS-------RLQLKVTAHQKKEAELQMQL-TESLKETDLLKGQLIKLQAELS------ELQETSEQAQS 706
Cdd:PRK11281  142 --NDLAEYNSQLVslqtqpeRAQAALYANSQRLQQIRNLLkGGKVGGKALRPSQRVLLQAEQAllnaqnDLQRKSLEGNT 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  707 KFKSEKQSRRQL-ELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERcraeEEIDEIRKS--YQEELDKLRQLLKKAR 783
Cdd:PRK11281  220 QLQDLLQKQRDYlTARIQRLEHQLQLLQEAINSKRLTLSEKTVQEAQSQ----DEAARIQANplVAQELEINLQLSQRLL 295

                         250       260
                  ....*....|....*....|...
gi 961710477  784 VSTDQAAaeqlSLVQAELQT-QW 805
Cdd:PRK11281  296 KATEKLN----TLTQQNLRVkNW 314
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 557-904 3.31e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 54.74  E-value: 3.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   557 TMETSMIMGNIQRIIQE----NERLKQEILEK--SSRIEEQNDKISELIERNQRyveqsnlmMEKRNNSLQTATENTQAr 630
Cdd:pfam17380  264 TMTENEFLNQLLHIVQHqkavSERQQQEKFEKmeQERLRQEKEEKAREVERRRK--------LEEAEKARQAEMDRQAA- 334

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   631 vLHAEQEKAKVTEEltaatAQVSRLQLKvtaHQKKEAElQMQLTESLKETDLLKgQLIKLQAELSELQETSEQAQSKFKS 710
Cdd:pfam17380  335 -IYAEQERMAMERE-----RELERIRQE---ERKRELE-RIRQEEIAMEISRMR-ELERLQMERQQKNERVRQELEAARK 403

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   711 EKQSRRQLELKVTSLEEELADLRAEKESLEKnlsERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQ--------LLKKA 782
Cdd:pfam17380  404 VKILEEERQRKIQQQKVEMEQIRAEQEEARQ---REVRRLEEERAREMERVRLEEQERQQQVERLRQqeeerkrkKLELE 480

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   783 RVSTDQAAAEQLSlvQAELQTQWEAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQNEQH 862
Cdd:pfam17380  481 KEKRDRKRAEEQR--RKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQM 558

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 961710477   863 TKDLENKSHMsgvaaaatDPSEKVKKIMNQVFQSLRGEFELE 904
Cdd:pfam17380  559 RKATEERSRL--------EAMEREREMMRQIVESEKARAEYE 592
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
566-861 3.35e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 54.77  E-value: 3.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  566 NIQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRN---NSLQTATENTQARVLHAEQEKAKVT 642
Cdd:COG4717   126 QLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEeleELLEQLSLATEEELQDLAEELEELQ 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  643 EELTAATAQVSRLQLKVTAHQKKEAELQMQLtESLKETDLLKGQLIKLQAeLSELQETSEQAQSKFKSEKQSRRQLELKV 722
Cdd:COG4717   206 QRLAELEEELEEAQEELEELEEELEQLENEL-EAAALEERLKEARLLLLI-AAALLALLGLGGSLLSLILTIAGVLFLVL 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  723 TSLEEELADLRAEKESLEKNLSERKKKSAQERcRAEEEIDEIRKSYQ-------EELDKLRQLLKKARVSTDQAAAEQLS 795
Cdd:COG4717   284 GLLALLFLLLAREKASLGKEAEELQALPALEE-LEEEELEELLAALGlppdlspEELLELLDRIEELQELLREAEELEEE 362

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 961710477  796 LVQAELQTQWEAkcehLLASAKDEHLLQYQEVCAQrdasQQELLRLQEKCLALQAQVTALTEQNEQ 861
Cdd:COG4717   363 LQLEELEQEIAA----LLAEAGVEDEEELRAALEQ----AEEYQELKEELEELEEQLEELLGELEE 420
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 636-870 3.52e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 54.97  E-value: 3.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   636 QEKAKVTEELTAaTAQVSRLQLKVTAHQK----------KEAELQMQLTESLKET---------DLLKgQLIKLQAE--- 693
Cdd:TIGR00618  163 KEKKELLMNLFP-LDQYTQLALMEFAKKKslhgkaelltLRSQLLTLCTPCMPDTyherkqvleKELK-HLREALQQtqq 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   694 ----LSELQETSEQAQSKFKSEKQSRRQLElKVTSLEEELADLRAEKEsleknlSERKKKSAQERCRAEEEIDEIRKSYQ 769
Cdd:TIGR00618  241 shayLTQKREAQEEQLKKQQLLKQLRARIE-ELRAQEAVLEETQERIN------RARKAAPLAAHIKAVTQIEQQAQRIH 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   770 EELDKLRQLLKKARVSTDQAAAEQLSL-VQAELQTQWEAKCEHlLASAKDEHLLQYQEVCAQRdASQQELLRLQEKCLAL 848
Cdd:TIGR00618  314 TELQSKMRSRAKLLMKRAAHVKQQSSIeEQRRLLQTLHSQEIH-IRDAHEVATSIREISCQQH-TLTQHIHTLQQQKTTL 391

                          250       260
                   ....*....|....*....|....*..
gi 961710477   849 QAQVTAL-----TEQNEQHTKDLENKS 870
Cdd:TIGR00618  392 TQKLQSLckeldILQREQATIDTRTSA 418
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 572-808 3.73e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.00  E-value: 3.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  572 QENERLKQEILEKSSRIEEQNDKISELiernqryveqsnlmmEKRNNSLQTATENTQARVLHAEQEKAKVTEELTAATAQ 651
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAAL---------------KKEEKALLKQLAALERRIAALARRIRALEQELAALEAE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  652 VSRLQlkvtahqKKEAELQMQLTEslkETDLLKGQLIKLQ-----AELSEL--QETSEQAQSKFKSEKQSRRQLELKVTS 724
Cdd:COG4942    85 LAELE-------KEIAELRAELEA---QKEELAELLRALYrlgrqPPLALLlsPEDFLDAVRRLQYLKYLAPARREQAEE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  725 LEEELADLRAEKESLEKNLsERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKK--ARVSTDQAAAEQLSLVQAELQ 802
Cdd:COG4942   155 LRADLAELAALRAELEAER-AELEALLAELEEERAALEALKAERQKLLARLEKELAElaAELAELQQEAEELEALIARLE 233


                  ....*.
gi 961710477  803 TQWEAK 808
Cdd:COG4942   234 AEAAAA 239
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
511-781 3.99e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 54.68  E-value: 3.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  511 EARQHNTEIRMAVSKVADKMDHLMTKVEELQK-----HSAGNSLLLPSMSVTMETSM-IMGNIQRIIQENERLKQEILEK 584
Cdd:PRK03918  395 ELEKAKEEIEEEISKITARIGELKKEIKELKKaieelKKAKGKCPVCGRELTEEHRKeLLEEYTAELKRIEKELKEIEEK 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  585 SSRIEEQNDKISELIERNQRYVEQSNLMMEKRNnsLQTATENTQARVLHAEQEKA-KVTEELTAATAQVSRLQLKVtahq 663
Cdd:PRK03918  475 ERKLRKELRELEKVLKKESELIKLKELAEQLKE--LEEKLKKYNLEELEKKAEEYeKLKEKLIKLKGEIKSLKKEL---- 548

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  664 KKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQ---------------------AQSKFKSEKQSRRQLELKV 722
Cdd:PRK03918  549 EKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEeleerlkelepfyneylelkdAEKELEREEKELKKLEEEL 628

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 961710477  723 TSLEEELADLRAEKESLEKNLSERKKKSAQERCR-AEEEIDEIRKSYQ------EELDKLRQLLKK 781
Cdd:PRK03918  629 DKAFEELAETEKRLEELRKELEELEKKYSEEEYEeLREEYLELSRELAglraelEELEKRREEIKK 694
Filament pfam00038
Intermediate filament protein;
588-860 6.29e-07

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 52.62  E-value: 6.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   588 IEEQNDKISELIERnQRYVEQSNLMMEkrnnslqtatentqarvlhaeqekAKVTEELTAATAQVSRLQLkvtAHQKKEA 667
Cdd:pfam00038    6 LQELNDRLASYIDK-VRFLEQQNKLLE------------------------TKISELRQKKGAEPSRLYS---LYEKEIE 57

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   668 ELQMQLteslketDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRqlelkvtSLEEELADLR--AEKESLEKNLSE 745
Cdd:pfam00038   58 DLRRQL-------DTLTVERARLQLELDNLRLAAEDFRQKYEDELNLRT-------SAENDLVGLRkdLDEATLARVDLE 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   746 RKKKSAQErcraeeEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQA--ELQTQWEAKCEHLLASAKDEHLLQ 823
Cdd:pfam00038  124 AKIESLKE------ELAFLKKNHEEEVRELQAQVSDTQVNVEMDAARKLDLTSAlaEIRAQYEEIAAKNREEAEEWYQSK 197

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 961710477   824 YQEVCAQRD-------ASQQELLRLQEKCLALQAQVTALTEQNE 860
Cdd:pfam00038  198 LEELQQAAArngdalrSAKEEITELRRTIQSLEIELQSLKKQKA 241
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 530-849 6.40e-07

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 53.36  E-value: 6.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   530 MDHLMTKVEELQKHSAGNSLLLPSMSVTMetsmimgnIQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQS 609
Cdd:pfam07888    3 LDELVTLEEESHGEEGGTDMLLVVPRAEL--------LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   610 NLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQmQLTESLKETDLLKgqlik 689
Cdd:pfam07888   75 RRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELE-EDIKTLTQRVLER----- 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   690 lQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQercraeeeideirksYQ 769
Cdd:pfam07888  149 -ETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQ---------------LQ 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   770 EELDKLRQLLKKA--RVSTDQAAAEQLSLVQaelqtqweakcEHLLASAKDEHLL--QYQEVCAQRDASQQEL--LRLQE 843
Cdd:pfam07888  213 DTITTLTQKLTTAhrKEAENEALLEELRSLQ-----------ERLNASERKVEGLgeELSSMAAQRDRTQAELhqARLQA 281


                   ....*.
gi 961710477   844 KCLALQ 849
Cdd:pfam07888  282 AQLTLQ 287
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
633-869 7.49e-07

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 52.98  E-value: 7.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  633 HAEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTEslketdlLKGQLIKLQAELselqetsEQAQSKFKSEK 712
Cdd:COG4372    42 KLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEE-------LNEQLQAAQAEL-------AQAQEELESLQ 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  713 QSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQercrAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAE 792
Cdd:COG4372   108 EEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAE----REEELKELEEQLESLQEELAALEQELQALSEAEAEQ 183

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 961710477  793 QLslvqAELQTQWEAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQNEQHTKDLENK 869
Cdd:COG4372   184 AL----DELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVI 256
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 471-866 8.29e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 53.43  E-value: 8.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   471 YPHASAVTSQLQPARPLYPTPLSQSPHFQGSSDMASFLM------TEARQHNTEIRMAVSKVADKMDHLMTKVEELQKHS 544
Cdd:TIGR00618  330 RAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIReiscqqHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQ 409

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   545 AGNSLLLPSMSVTMETSMIMGNIQRIIQENERLKQEILEKSSRIEEQndKISELIERNQRYVEQSNLMMEKRNNSLQ--- 621
Cdd:TIGR00618  410 ATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKL--EKIHLQESAQSLKEREQQLQTKEQIHLQetr 487

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   622 TATENTQARVLHAEQE------------KAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIK 689
Cdd:TIGR00618  488 KKAVVLARLLELQEEPcplcgscihpnpARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQE 567

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   690 LQAELSEL----QETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIR 765
Cdd:TIGR00618  568 IQQSFSILtqcdNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTA 647

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   766 KS-YQEELDKLRQLLKKARVSTDQaaAEQLSLVQAELQtqwEAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLRL-QE 843
Cdd:TIGR00618  648 LHaLQLTLTQERVREHALSIRVLP--KELLASRQLALQ---KMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREfNE 722

                          410       420
                   ....*....|....*....|...
gi 961710477   844 KCLALQAQVTALTEQNEQHTKDL 866
Cdd:TIGR00618  723 IENASSSLGSDLAAREDALNQSL 745
PTZ00121 PTZ00121
MAEBL; Provisional
 511-808 8.44e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.61  E-value: 8.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  511 EARQHNTEIRM-AVSKV--ADKMDHLMTKVEELQKHSAGNSLLLPSMSVtmetsmiMGNIQRIIQENERLKQEILEKSsr 587
Cdd:PTZ00121 1216 EARKAEDAKKAeAVKKAeeAKKDAEEAKKAEEERNNEEIRKFEEARMAH-------FARRQAAIKAEEARKADELKKA-- 1286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  588 ieEQNDKISELIERNQ-RYVEQSNLMME--KRNNSLQTATENTQ--ARVLHAEQEKAKVTEELTAATAQVSRLQLKVTAH 662
Cdd:PTZ00121 1287 --EEKKKADEAKKAEEkKKADEAKKKAEeaKKADEAKKKAEEAKkkADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEE 1364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  663 QKKEAELQMQltESLKETDLLK--GQLIKLQAELSE-LQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADlRAEKESL 739
Cdd:PTZ00121 1365 KAEAAEKKKE--EAKKKADAAKkkAEEKKKADEAKKkAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKAD-EAKKKAE 1441

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 961710477  740 EKNLSERKKKSAQERCRAEE---EIDEIRKSyqEELDKLRQLLKKARVSTDQaaAEQLSLVQAELQTQWEAK 808
Cdd:PTZ00121 1442 EAKKADEAKKKAEEAKKAEEakkKAEEAKKA--DEAKKKAEEAKKADEAKKK--AEEAKKKADEAKKAAEAK 1509
PRK11281 PRK11281
mechanosensitive channel MscK;
656-868 8.58e-07

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 53.38  E-value: 8.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  656 QLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFkseKQSRRQLE---------------- 719
Cdd:PRK11281   44 QLDALNKQKLLEAEDKLVQQDLEQTLALLDKIDRQKEETEQLKQQLAQAPAKL---RQAQAELEalkddndeetretlst 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  720 LKVTSLEEELADLRAEKESLEKNLSERKKK--SAQERC-RAEEEIDEirksYQEELDKLRQLLKKARVSTDQAAAEQLSL 796
Cdd:PRK11281  121 LSLRQLESRLAQTLDQLQNAQNDLAEYNSQlvSLQTQPeRAQAALYA----NSQRLQQIRNLLKGGKVGGKALRPSQRVL 196

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 961710477  797 VQAELQtQWEAKCEHLLASAKDEHLLQ--YQevcAQRDASQQELLRLQEKCLALQAQVTA-LTEQNEQHTKDLEN 868
Cdd:PRK11281  197 LQAEQA-LLNAQNDLQRKSLEGNTQLQdlLQ---KQRDYLTARIQRLEHQLQLLQEAINSkRLTLSEKTVQEAQS 267
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 576-866 9.25e-07

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 53.22  E-value: 9.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   576 RLKQEILEKSSRIEEQNDKISELIER-NQRYVEQSNLMMEKRNNSLQTATENTQARVLHAE------------QEKAKVT 642
Cdd:pfam07111  321 QLKAQDLEHRDSVKQLRGQVAELQEQvTSQSQEQAILQRALQDKAAEVEVERMSAKGLQMElsraqearrrqqQQTASAE 400

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   643 EELTAATAQVSRLQLKVTAHQKKEAE-------LQMQLTESLKETDLLKG------QLIKLQAELSELQETSEQAQSKFK 709
Cdd:pfam07111  401 EQLKFVVNAMSSTQIWLETTMTRVEQavaripsLSNRLSYAVRKVHTIKGlmarkvALAQLRQESCPPPPPAPPVDADLS 480

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   710 SEKQSRRQ--------LELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEE-------EIDEIRKSYQE---E 771
Cdd:pfam07111  481 LELEQLREernrldaeLQLSAHLIQQEVGRAREQGEAERQQLSEVAQQLEQELQRAQEslasvgqQLEVARQGQQEsteE 560

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   772 LDKLRQLLKKARVSTDQAAAEQLSLVQAELQTQWeAKCEHLLASAKDEH------LLQYQEVCAQRDASQQELLRLQEKC 845
Cdd:pfam07111  561 AASLRQELTQQQEIYGQALQEKVAEVETRLREQL-SDTKRRLNEARREQakavvsLRQIQHRATQEKERNQELRRLQDEA 639

                          330       340
                   ....*....|....*....|.
gi 961710477   846 LALQAQVTALTEQNEQHTKDL 866
Cdd:pfam07111  640 RKEEGQRLARRVQELERDKNL 660
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 634-807 1.32e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 52.14  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  634 AEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQET------------- 700
Cdd:COG3883    21 KQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREElgeraralyrsgg 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  701 ---------------------------SEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQE 753
Cdd:COG3883   101 svsyldvllgsesfsdfldrlsalskiADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQ 180

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 961710477  754 RcRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQTQWEA 807
Cdd:COG3883   181 E-ALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 576-843 1.58e-06

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 51.74  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   576 RLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAkvteELTAATAQVSRl 655
Cdd:pfam15905   55 KVKSLELKKKSQKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVREKT----SLSASVASLEK- 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   656 qlkvtahqkkeaelqmQLTESLKETDLLK------GQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEEL 729
Cdd:pfam15905  130 ----------------QLLELTRVNELLKakfsedGTQKKMSSLSMELMKLRNKLEAKMKEVMAKQEGMEGKLQVTQKNL 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   730 ADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRK--SYQEELDKLRQLLKKARVSTDQAAAEQLSLVQA------EL 801
Cdd:pfam15905  194 EHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITElsCVSEQVEKYKLDIAQLEELLKEKNDEIESLKQSleekeqEL 273

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 961710477   802 QTQWE---AKCEhLLASAKDEHLLQYQEVCAQRDASQQEL---LRLQE 843
Cdd:pfam15905  274 SKQIKdlnEKCK-LLESEKEELLREYEEKEQTLNAELEELkekLTLEE 320
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 571-898 1.60e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 52.74  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   571 IQENE-RLKQEILEKSSRIEEQNDKISELIERNQryvEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELTAAT 649
Cdd:TIGR00606  370 IQSLAtRLELDGFERGPFSERQIKNFHTLVIERQ---EDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKK 446

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   650 AQVSRlqlKVTAHQKKEAELQmQLTESLKETDLLKGQLIKLQAELSELQETS--EQAQSKFKSEKQSRRQLELKVTSLEE 727
Cdd:TIGR00606  447 EILEK---KQEELKFVIKELQ-QLEGSSDRILELDQELRKAERELSKAEKNSltETLKKEVKSLQNEKADLDRKLRKLDQ 522

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   728 ELADLRAEKESLEKNLSERKKKSAqercrAEEEIDEIRKSYQEEL--------------DKLRQLLKKARVSTDQAAAEQ 793
Cdd:TIGR00606  523 EMEQLNHHTTTRTQMEMLTKDKMD-----KDEQIRKIKSRHSDELtsllgyfpnkkqleDWLHSKSKEINQTRDRLAKLN 597

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   794 LSLVQAE-LQTQWEAKCEhllasAKDEHLLQYQ----EVCAQRDaSQQELLRLQEKCLALQAQVTALTEQNEQHTKDLEN 868
Cdd:TIGR00606  598 KELASLEqNKNHINNELE-----SKEEQLSSYEdklfDVCGSQD-EESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQ 671

                          330       340       350
                   ....*....|....*....|....*....|
gi 961710477   869 KSHMSGVAAAATDPSEKVKKIMNQVFQSLR 898
Cdd:TIGR00606  672 LTDENQSCCPVCQRVFQTEAELQEFISDLQ 701
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 631-874 1.84e-06

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 52.07  E-value: 1.84e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   631 VLHAEQEKAKVTE--ELTAATAQVSRLQLKvtahqKKEAELQMQLTE-SLKETDLLKGQLIKLQAELSELQEtsEQAQSK 707
Cdd:pfam09731  235 VEKAQSLAKLVDQykELVASERIVFQQELV-----SIFPDIIPVLKEdNLLSNDDLNSLIAHAHREIDQLSK--KLAELK 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   708 FKSEKQSRRQLELKVTSLEEELADLRAEKESleknlsERKKKSAQERCRAEEEIDEIRKSYQEeldKLRQLLKKARVSTD 787
Cdd:pfam09731  308 KREEKHIERALEKQKEELDKLAEELSARLEE------VRAADEAQLRLEFEREREEIRESYEE---KLRTELERQAEAHE 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   788 QAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLLQYQEVCAQ-RDASQQELLRLQEKCLALQAQVTALTEQNEQHTkdL 866
Cdd:pfam09731  379 EHLKDVLVEQEIELQREFLQDIKEKVEEERAGRLLKLNELLANlKGLEKATSSHSEVEDENRKAQQLWLAVEALRST--L 456


                   ....*...
gi 961710477   867 ENKSHMSG 874
Cdd:pfam09731  457 EDGSADSR 464
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 650-821 1.87e-06

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 52.16  E-value: 1.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   650 AQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKvtsLEEEl 729
Cdd:pfam09726  402 QDIKKLKAELQASRQTEQELRSQISSLTSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTVQQLEKR---LKAE- 477

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   730 ADLRAekeSLEKNLSERKKKSAQERCRAEE----------EIDEIRKSYQEELD-KLRQLLKKARVSTDQAAaeQLSLVQ 798
Cdd:pfam09726  478 QEARA---SAEKQLAEEKKRKKEEEATAARavalaaasrgECTESLKQRKRELEsEIKKLTHDIKLKEEQIR--ELEIKV 552

                          170       180       190
                   ....*....|....*....|....*....|
gi 961710477   799 AELQTQWE-AKCEHLLASA------KDEHL 821
Cdd:pfam09726  553 QELRKYKEsEKDTEVLMSAlsamqdKNQHL 582
mukB PRK04863
chromosome partition protein MukB;
643-871 1.92e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 52.65  E-value: 1.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  643 EELTAATAQVSRLQLKVTAHQKKEAELQMQLtESLKETDLLKGQLI---------KLQAELSELQETSEQAQSKFKSEKQ 713
Cdd:PRK04863  837 AELRQLNRRRVELERALADHESQEQQQRSQL-EQAKEGLSALNRLLprlnlladeTLADRVEEIREQLDEAEEAKRFVQQ 915

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  714 SRRQLELkvtsLEEELADLRAEKESLEK-----NLSERKKKSAQERCRAEEEIDEIRK--SYQEEL----------DKLR 776
Cdd:PRK04863  916 HGNALAQ----LEPIVSVLQSDPEQFEQlkqdyQQAQQTQRDAKQQAFALTEVVQRRAhfSYEDAAemlaknsdlnEKLR 991

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  777 QLLKKARVSTDQA------AAEQL---SLVQAELQTQWEAKCEHLLASAKDEHLLQYQ-----EVCA--QRDASQQELLR 840
Cdd:PRK04863  992 QRLEQAEQERTRAreqlrqAQAQLaqyNQVLASLKSSYDAKRQMLQELKQELQDLGVPadsgaEERAraRRDELHARLSA 1071

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 961710477  841 LQEKCLALQAQVT----ALTEQNEQHTKdLENKSH 871
Cdd:PRK04863 1072 NRSRRNQLEKQLTfceaEMDNLTKKLRK-LERDYH 1105
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 567-791 2.00e-06

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 51.88  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  567 IQRIIQENERLKQEILEKSSRIEEQNDKISEL------------------IERNQRYVEQSNL----MMEKRNNSLQTAT 624
Cdd:COG5185   277 SKRLNENANNLIKQFENTKEKIAEYTKSIDIKkatesleeqlaaaeaeqeLEESKRETETGIQnltaEIEQGQESLTENL 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  625 ENTQARV--LHAEQEKAKVTEELTAATAQVS----RLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIK-LQAELSEL 697
Cdd:COG5185   357 EAIKEEIenIVGEVELSKSSEELDSFKDTIEstkeSLDEIPQNQRGYAQEILATLEDTLKAADRQIEELQRqIEQATSSN 436

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  698 QETSEQAQSKFKSEKQSRRQLElkvtslEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQ 777
Cdd:COG5185   437 EEVSKLLNELISELNKVMREAD------EESQSRLEEAYDEINRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLER 510

                         250
                  ....*....|....
gi 961710477  778 LLKKARVSTDQAAA 791
Cdd:COG5185   511 QLEGVRSKLDQVAE 524
46 PHA02562
endonuclease subunit; Provisional
 502-749 2.08e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 51.94  E-value: 2.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  502 SDMASFLMTEARQHNTEIRMavskVADKMDHLMTKV-------EELQKHSAGNSLLLPSMSVTMetsmiMGNIQRIIQEN 574
Cdd:PHA02562  166 SEMDKLNKDKIRELNQQIQT----LDMKIDHIQQQIktynkniEEQRKKNGENIARKQNKYDEL-----VEEAKTIKAEI 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  575 ERLKQEILEKSSRIEEQNDKISELierNQRYVEQSNLM--------MEKRNNSLQTATENtqarvLHAEQEK-AKVTEEL 645
Cdd:PHA02562  237 EELTDELLNLVMDIEDPSAALNKL---NTAAAKIKSKIeqfqkvikMYEKGGVCPTCTQQ-----ISEGPDRiTKIKDKL 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  646 TAATAQVSRLQLKVTAHQKKE---AELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKqsrrqlelkv 722
Cdd:PHA02562  309 KELQHSLEKLDTAIDELEEIMdefNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNA---------- 378

                         250       260
                  ....*....|....*....|....*..
gi 961710477  723 tsleEELADLRAEKESLEKNLSERKKK 749
Cdd:PHA02562  379 ----EELAKLQDELDKIVKTKSELVKE 401
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
625-795 2.17e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.08  E-value: 2.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  625 ENTQARVLHAEQEKAKVTEELTAATAQVSRLQlkvtaHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQA 704
Cdd:COG4717    84 EEKEEEYAELQEELEELEEELEELEAELEELR-----EELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEEL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  705 QSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIrksyQEELDKLRQLLKKARV 784
Cdd:COG4717   159 RELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEA----QEELEELEEELEQLEN 234

                         170
                  ....*....|..
gi 961710477  785 S-TDQAAAEQLS 795
Cdd:COG4717   235 ElEAAALEERLK 246
Rab5-bind pfam09311
Rabaptin-like protein; Members of this family are predominantly found in Rabaptin and allow ...
 588-852 2.34e-06

Rabaptin-like protein; Members of this family are predominantly found in Rabaptin and allow for binding to the GTPase Rab5. This interaction is necessary and sufficient for Rab5-dependent recruitment of Rabaptin5 to early endosomal membranes.


Pssm-ID: 462752 [Multi-domain]  Cd Length: 307  Bit Score: 50.74  E-value: 2.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   588 IEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQtatentqarvlhaEQEKaKVTEELTAATAQVSRLQLKVTAHQKKEA 667
Cdd:pfam09311   14 IQEQEAETRDQVKKLQEMLRQANDQLEKTMKDKK-------------ELED-KMNQLSEETSNQVSTLAKRNQKSETLLD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   668 ELQMQLTESLKET----DLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRR-----------QLELKVTSLEEELADL 732
Cdd:pfam09311   80 ELQQAFSQAKRNFqdqlAVLMDSREQVSDELVRLQKDNESLQGKHSLHVSLQQaekfdmpdtvqELQELVLKYREELIEV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   733 RAEKESLEKNLSER----KKKSAQERCRAEeeidEIRKSYQEELDKLRQLLkkARVSTDQAAAEQLSLVQAELQTQWEAK 808
Cdd:pfam09311  160 RTAADHMEEKLKAEilflKEQIQAEQCLKE----NLEETLQAEIENCKEEI--ASISSLKVELERIKAEKEQLENGLTEK 233

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 961710477   809 CEHL--LASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQV 852
Cdd:pfam09311  234 IRQLedLQTTKGSLETQLKKETNEKAAVEQLVFEEKNKAQRLQTEL 279
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 634-870 2.82e-06

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 49.99  E-value: 2.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   634 AEQEKAKVTEELTAATAQVSRLQlkvtAHQKKEAELQMQLTESLKETDLLKGQLIKLQAelselqetSEQAQSKFKSEKQ 713
Cdd:pfam12795   11 DEAAKKKLLQDLQQALSLLDKID----ASKQRAAAYQKALDDAPAELRELRQELAALQA--------KAEAAPKEILASL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   714 SRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAqercRAEEEIDEIRKsyqeELDKLRQLLKKARVSTDQAAAEQ 793
Cdd:pfam12795   79 SLEELEQRLLQTSAQLQELQNQLAQLNSQLIELQTRPE----RAQQQLSEARQ----RLQQIRNRLNGPAPPGEPLSEAQ 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   794 LSLVQAELQTQW----EAKCEHLLASAKDEhLLQyqevcAQRDASQQELLRLQEKCLALQAQVT----ALTEQNEQHTKD 865
Cdd:pfam12795  151 RWALQAELAALKaqidMLEQELLSNNNRQD-LLK-----ARRDLLTLRIQRLEQQLQALQELLNekrlQEAEQAVAQTEQ 224


                   ....*
gi 961710477   866 LENKS 870
Cdd:pfam12795  225 LAEEA 229
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
641-858 3.20e-06

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 50.29  E-value: 3.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  641 VTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLEL 720
Cdd:COG1340     6 LSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELNE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  721 KVTSLEEELADLRAEKEslEKNLSERKKKSAQERCRAEEE---------------IDEIRKsYQEELDKLRQLLKKAR-V 784
Cdd:COG1340    86 KLNELREELDELRKELA--ELNKAGGSIDKLRKEIERLEWrqqtevlspeeekelVEKIKE-LEKELEKAKKALEKNEkL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 961710477  785 STDQAAAEQLSLVQAELQTQWEAkcehlLASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQ 858
Cdd:COG1340   163 KELRAELKELRKEAEEIHKKIKE-----LAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADELHEE 231
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
565-870 3.25e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 51.58  E-value: 3.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  565 GNIQRIIQENERLKQEILEKSSRIEEQNDKISE---------------------LIERN--------------------- 602
Cdd:PRK02224  237 DEADEVLEEHEERREELETLEAEIEDLRETIAEterereelaeevrdlrerleeLEEERddllaeaglddadaeavearr 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  603 ----------QRYVEQSNLMMEKRNNSLQTATEN------------TQARVLHAEQEKAKVT-----EELTAATAQVSRL 655
Cdd:PRK02224  317 eeledrdeelRDRLEECRVAAQAHNEEAESLREDaddleeraeelrEEAAELESELEEAREAvedrrEEIEELEEEIEEL 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  656 QLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEK-----------------QSRRQl 718
Cdd:PRK02224  397 RERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKcpecgqpvegsphvetiEEDRE- 475

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  719 elKVTSLEEELADLRAEKESLEKNLSE---------RKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKAR------ 783
Cdd:PRK02224  476 --RVEELEAELEDLEEEVEEVEERLERaedlveaedRIERLEERREDLEELIAERRETIEEKRERAEELRERAAeleaea 553

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  784 VSTDQAAAEQLSLVQAELQTQweAKCEHLLASAKD--EHLLQYQEVCAQRDASQQELLRLQEKclalqaqVTALTEQNEQ 861
Cdd:PRK02224  554 EEKREAAAEAEEEAEEAREEV--AELNSKLAELKEriESLERIRTLLAAIADAEDEIERLREK-------REALAELNDE 624


                  ....*....
gi 961710477  862 HTKDLENKS 870
Cdd:PRK02224  625 RRERLAEKR 633
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
575-817 3.82e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 51.19  E-value: 3.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  575 ERLKQEILEKSS-----RIEEQNDKISELIERNQRYVEQSNLMMEKRNN--SLQTATENTQARVLHAEQEKAKVTEELTA 647
Cdd:PRK02224  190 DQLKAQIEEKEEkdlheRLNGLESELAELDEEIERYEEQREQARETRDEadEVLEEHEERREELETLEAEIEDLRETIAE 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  648 ATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEE 727
Cdd:PRK02224  270 TEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLRE 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  728 ELADL-------RAEKESLEKNLSE-----RKKKSAQERCraEEEIDEIRKSYQ---EELDKLRQLLKKARvSTDQAAAE 792
Cdd:PRK02224  350 DADDLeeraeelREEAAELESELEEareavEDRREEIEEL--EEEIEELRERFGdapVDLGNAEDFLEELR-EERDELRE 426

                         250       260
                  ....*....|....*....|....*..
gi 961710477  793 QLSLVQAELQTQWE--AKCEHLLASAK 817
Cdd:PRK02224  427 REAELEATLRTARErvEEAEALLEAGK 453
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 518-921 4.97e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 50.88  E-value: 4.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   518 EIRMAVSKVADKMDHLMTKVEELQKHsAGNSLLlpSMSVTMETSMimGNIQRIIQE-----NERLKQ------EILEKSS 586
Cdd:pfam05483  180 ETRQVYMDLNNNIEKMILAFEELRVQ-AENARL--EMHFKLKEDH--EKIQHLEEEykkeiNDKEKQvsllliQITEKEN 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   587 R-------IEEQNDKISELIERNQRYVEQSNLMMEKRNNsLQTATENTQARVLHAEQEKAKVTEELTAAT---------- 649
Cdd:pfam05483  255 KmkdltflLEESRDKANQLEEKTKLQDENLKELIEKKDH-LTKELEDIKMSLQRSMSTQKALEEDLQIATkticqlteek 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   650 -AQVSRLQLKVTAHQKKEAELQM---QLTESL--------KETDLLKGQLIKLQAELSELQEtseqaQSKFKSEKqsrrQ 717
Cdd:pfam05483  334 eAQMEELNKAKAAHSFVVTEFEAttcSLEELLrteqqrleKNEDQLKIITMELQKKSSELEE-----MTKFKNNK----E 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   718 LELkvtsleEELADLRAEKESLeknLSERKK--KSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKARVStDQAAAEQLS 795
Cdd:pfam05483  405 VEL------EELKKILAEDEKL---LDEKKQfeKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTS-EEHYLKEVE 474

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   796 LVQAELQTQWEAKCEhlLASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQNEQ-HTKDLENKSHMSG 874
Cdd:pfam05483  475 DLKTELEKEKLKNIE--LTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENlEEKEMNLRDELES 552

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*...
gi 961710477   875 VAAAATDPSEKVKKIMNQVFQSLRG-EFELEESYNGRAVLGTIMNTIK 921
Cdd:pfam05483  553 VREEFIQKGDEVKCKLDKSEENARSiEYEVLKKEKQMKILENKCNNLK 600
COG5022 COG5022
Myosin heavy chain [General function prediction only];
579-934 5.55e-06

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 50.85  E-value: 5.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  579 QEILEKSSRIEEQNDKISElIERNQRyveqsnlmMEKRNNSLQTATEntQARVLHAEQEKAKVTEELTAaTAQVSRLQLK 658
Cdd:COG5022   800 QPLLSLLGSRKEYRSYLAC-IIKLQK--------TIKREKKLRETEE--VEFSLKAEVLIQKFGRSLKA-KKRFSLLKKE 867

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  659 VTAHQ--KKEAELQMQLTE---SLKETDLLKGQLIKLQAELSEL---QETSEQAQSKFKSEKQSRRQLELKVTSLEEELA 730
Cdd:COG5022   868 TIYLQsaQRVELAERQLQElkiDVKSISSLKLVNLELESEIIELkksLSSDLIENLEFKTELIARLKKLLNNIDLEEGPS 947

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  731 DLRAEKESLEKNLSERK--KKSAQERCRA----EEEIDEIRKSyQEELDKLRQLLKKARVSTD--QAAAEQLSLVQAELQ 802
Cdd:COG5022   948 IEYVKLPELNKLHEVESklKETSEEYEDLlkksTILVREGNKA-NSELKNFKKELAELSKQYGalQESTKQLKELPVEVA 1026

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  803 TQWEAkcEHLLASAKDEhLLQYQEVCAQRDASQQELLRLQEKCLALQAQ-----VTALTEQNEQHTKDLENKSHMSGVAA 877
Cdd:COG5022  1027 ELQSA--SKIISSESTE-LSILKPLQKLKGLLLLENNQLQARYKALKLRrenslLDDKQLYQLESTENLLKTINVKDLEV 1103

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 961710477  878 AATDPSEKVKKIMNQVFQSLRGEFELEESYNGRAVLgtimNTIKMVTLQL-LNQHEQD 934
Cdd:COG5022  1104 TNRNLVKPANVLQFIVAQMIKLNLLQEISKFLSQLV----NTLEPVFQKLsVLQLELD 1157
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 686-902 5.81e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 50.72  E-value: 5.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  686 QLIKLQAELSELQEtsEQAQSKFKSEKQSR--RQLELKVTSL---------EEELADLRAEKESLEKNLSERKKKSAQER 754
Cdd:COG3096   786 RLEELRAERDELAE--QYAKASFDVQKLQRlhQAFSQFVGGHlavafapdpEAELAALRQRRSELERELAQHRAQEQQLR 863

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  755 craeEEIDEIRksyqEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQTQWEAKC---EHLLASAKDEHLLQY-QEVCAQ 830
Cdd:COG3096   864 ----QQLDQLK----EQLQLLNKLLPQANLLADETLADRLEELREELDAAQEAQAfiqQHGKALAQLEPLVAVlQSDPEQ 935

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  831 RDASQQELLRLQEKCLALQAQVTALTE--QNEQH------------TKDLENK--SHMSGVAAAATDPSEKVKKI----- 889
Cdd:COG3096   936 FEQLQADYLQAKEQQRRLKQQIFALSEvvQRRPHfsyedavgllgeNSDLNEKlrARLEQAEEARREAREQLRQAqaqys 1015

                         250
                  ....*....|....
gi 961710477  890 -MNQVFQSLRGEFE 902
Cdd:COG3096  1016 qYNQVLASLKSSRD 1029
mukB PRK04863
chromosome partition protein MukB;
558-867 6.47e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 50.73  E-value: 6.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  558 METSMImgniqriiqENERLKQEILEKSSrieeQNDKISELIERNQRYVeqSNLMMEKRNNslqtATENTQaRVLHAEQE 637
Cdd:PRK04863  235 MEAALR---------ENRMTLEAIRVTQS----DRDLFKHLITESTNYV--AADYMRHANE----RRVHLE-EALELRRE 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  638 KAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLtESLK-------ETDLLKGQLIKLQAELSELQETSEQAQSkfks 710
Cdd:PRK04863  295 LYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDY-QAASdhlnlvqTALRQQEKIERYQADLEELEERLEEQNE---- 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  711 ekqsrrqlelKVTSLEEELADLRAEKEsleknlserkkksaqercRAEEEIDEIRKS---YQEELDKLR----------Q 777
Cdd:PRK04863  370 ----------VVEEADEQQEENEARAE------------------AAEEEVDELKSQladYQQALDVQQtraiqyqqavQ 421

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  778 LLKKARVSTDQA--AAEQLSLVQAELQTQWEAKCEHLLA---------SAKDEHLLQYQEVCA------QRDASQ--QEL 838
Cdd:PRK04863  422 ALERAKQLCGLPdlTADNAEDWLEEFQAKEQEATEELLSleqklsvaqAAHSQFEQAYQLVRKiagevsRSEAWDvaREL 501

                         330       340
                  ....*....|....*....|....*....
gi 961710477  839 LRLQEKCLALQAQVTALteqnEQHTKDLE 867
Cdd:PRK04863  502 LRRLREQRHLAEQLQQL----RMRLSELE 526
PRK00106 PRK00106
ribonuclease Y;
631-800 9.53e-06

ribonuclease Y;


Pssm-ID: 178867 [Multi-domain]  Cd Length: 535  Bit Score: 49.87  E-value: 9.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  631 VLHAEQEKAKVTEELTAATAQvsrlQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIkLQAElSELQETSEQAQSKFKS 710
Cdd:PRK00106   21 LISIKMKSAKEAAELTLLNAE----QEAVNLRGKAERDAEHIKKTAKRESKALKKELL-LEAK-EEARKYREEIEQEFKS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  711 EKQSRRQLELKVT----SL---EEELADLRAEKESLEKNLSErKKKSAQERcraEEEIDEIRKSYQEELDKLRQLlkkar 783
Cdd:PRK00106   95 ERQELKQIESRLTeratSLdrkDENLSSKEKTLESKEQSLTD-KSKHIDER---EEQVEKLEEQKKAELERVAAL----- 165

                         170
                  ....*....|....*..
gi 961710477  784 vstDQAAAEQLSLVQAE 800
Cdd:PRK00106  166 ---SQAEAREIILAETE 179
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 578-846 9.79e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 50.12  E-value: 9.79e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   578 KQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEkrnnslqtATENTQARVLHAEQEKAKVTEELTAATAQV-SRLQ 656
Cdd:pfam15921  456 KNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLE--------SSERTVSDLTASLQEKERAIEATNAEITKLrSRVD 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   657 LKVT--AHQKKEAE-----------LQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQ-SKFKSEKQ-SRRQLEL- 720
Cdd:pfam15921  528 LKLQelQHLKNEGDhlrnvqteceaLKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQvEKAQLEKEiNDRRLELq 607

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   721 -----------KVTSLEEELADLRAEKESLEKNLSER---KKKSAQER---------CRAE-----EEIDEIRKSYQ--- 769
Cdd:pfam15921  608 efkilkdkkdaKIRELEARVSDLELEKVKLVNAGSERlraVKDIKQERdqllnevktSRNElnslsEDYEVLKRNFRnks 687

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   770 EELD----KLRQLLKKARVSTDQ---------------------------AAAEQLSLVQAELQTQWEA-----KCEHLL 813
Cdd:pfam15921  688 EEMEtttnKLKMQLKSAQSELEQtrntlksmegsdghamkvamgmqkqitAKRGQIDALQSKIQFLEEAmtnanKEKHFL 767

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 961710477   814 ASAKDEHLLQYQEVCAQRD--ASQQELLRLQEKCL 846
Cdd:pfam15921  768 KEEKNKLSQELSTVATEKNkmAGELEVLRSQERRL 802
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 574-780 1.01e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 50.05  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   574 NErLKQEIlEKSSRIEEQNDKISELIERNQRYVEQ-----------------SNLMMEKRNNSLQTATENTQAR---VLH 633
Cdd:TIGR01612 1486 NE-LKEHI-DKSKGCKDEADKNAKAIEKNKELFEQykkdvtellnkysalaiKNKFAKTKKDSEIIIKEIKDAHkkfILE 1563

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   634 AEQEKAKVTE--------ELTAATAQVSR-----LQLKVTAHQKKE---AELQMQLTESLKETDLLKGQLIKL-----QA 692
Cdd:TIGR01612 1564 AEKSEQKIKEikkekfriEDDAAKNDKSNkaaidIQLSLENFENKFlkiSDIKKKINDCLKETESIEKKISSFsidsqDT 1643

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   693 ELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEeladLRAEKESLEKNLSERKKKSaqeRCRAEEEIDEIRKSYQEEL 772
Cdd:TIGR01612 1644 ELKENGDNLNSLQEFLESLKDQKKNIEDKKKELDE----LDSEIEKIEIDVDQHKKNY---EIGIIEKIKEIAIANKEEI 1716


                   ....*...
gi 961710477   773 DKLRQLLK 780
Cdd:TIGR01612 1717 ESIKELIE 1724
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 573-867 1.14e-05

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 49.64  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   573 ENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSnlmMEKRNNSLQTATENTQ--ARVLHAEQEKAKVTEELTAATA 650
Cdd:pfam05667  223 EEEWNSQGLASRLTPEEYRKRKRTKLLKRIAEQLRSA---ALAGTEATSGASRSAQdlAELLSSFSGSSTTDTGLTKGSR 299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   651 QVSRLQLKVTAHQKKEAELQMQLTESLKETDLlkgqliKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELA 730
Cdd:pfam05667  300 FTHTEKLQFTNEAPAATSSPPTKVETEEELQQ------QREEELEELQEQLEDLESSIQELEKEIKKLESSIKQVEEELE 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   731 DLRAEKESLEKNLsERKKKSAQERCRAEEEIdeirksyqeelDKLRQLLkkarvstdQAAAEQLslvqAELQTQWEAKCE 810
Cdd:pfam05667  374 ELKEQNEELEKQY-KVKKKTLDLLPDAEENI-----------AKLQALV--------DASAQRL----VELAGQWEKHRV 429

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 961710477   811 HLLasakdEHLLQYQEVCAQR--DASQQ--ELLRLQEKCLalqaQVTALTEQNEQHTKDLE 867
Cdd:pfam05667  430 PLI-----EEYRALKEAKSNKedESQRKleEIKELREKIK----EVAEEAKQKEELYKQLV 481
mukB PRK04863
chromosome partition protein MukB;
572-776 1.28e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 49.96  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  572 QENERLKQEILEKSSRIEEQNDKISELIERNQR-----YvEQSNLMMEKrNNSLQtatENTQARVLHAEQEKAKVTEELT 646
Cdd:PRK04863  935 EQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQRrahfsY-EDAAEMLAK-NSDLN---EKLRQRLEQAEQERTRAREQLR 1009

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  647 AATAQVS-----RLQLKvTAHQKKEAELQmqltESLKETDLL-----KGQLIKLQAELSELQETSEQAQSKfksekqsRR 716
Cdd:PRK04863 1010 QAQAQLAqynqvLASLK-SSYDAKRQMLQ----ELKQELQDLgvpadSGAEERARARRDELHARLSANRSR-------RN 1077

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  717 QLELKVTSLEEELadlraekESLEKNLSERKKKSAQERcraeEEIDEIRKSYQEELDKLR 776
Cdd:PRK04863 1078 QLEKQLTFCEAEM-------DNLTKKLRKLERDYHEMR----EQVVNAKAGWCAVLRLVK 1126
DUF4618 pfam15397
Domain of unknown function (DUF4618); This family of proteins is found in eukaryotes. Proteins ...
 689-861 1.33e-05

Domain of unknown function (DUF4618); This family of proteins is found in eukaryotes. Proteins in this family are typically between 238 and 363 amino acids in length. There are two conserved sequence motifs: EYP and KCTPD.


Pssm-ID: 464704 [Multi-domain]  Cd Length: 258  Bit Score: 48.02  E-value: 1.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   689 KLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKEsleknlSERKKKSAQ----ERcraeeEIDEI 764
Cdd:pfam15397   64 QLQQAKAELQEWEEKEESKLNKLEQQLEQLNAKIQKTQEELNFLSTYKD------KEYPVKAVQianlVR-----QLQQL 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   765 RKSYQEELDKLRQLLKKarvstdqaaaeqlslVQAELQTQWEAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLR---- 840
Cdd:pfam15397  133 KDSQQDELDELEEMRRM---------------VLESLSRKIQKKKEKILSSLAEKTLSPYQESLLQKTRDNQVMLKeieq 197

                          170       180
                   ....*....|....*....|....*...
gi 961710477   841 -------LQEKCLALQAQVTALTEQNEQ 861
Cdd:pfam15397  198 frefideLEEEIPKLKAEVQQLQAQRQE 225
PRK12704 PRK12704
phosphodiesterase; Provisional
 652-804 1.47e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.01  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  652 VSRLQLKVTAHQK-KEAElqmQLTESLKETDLLKGQLIKLQAELsELQETSEQAQSKFKSEKQSRR--------QLELKV 722
Cdd:PRK12704   20 IGYFVRKKIAEAKiKEAE---EEAKRILEEAKKEAEAIKKEALL-EAKEEIHKLRNEFEKELRERRnelqklekRLLQKE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  723 TSLEEELADLRAEKESLEKNLS--ERKKKSAQERcraEEEIDEIrksYQEELDKLRQLlkkARVSTDQAAAEQLSLVQAE 800
Cdd:PRK12704   96 ENLDRKLELLEKREEELEKKEKelEQKQQELEKK---EEELEEL---IEEQLQELERI---SGLTAEEAKEILLEKVEEE 166


                  ....
gi 961710477  801 LQTQ 804
Cdd:PRK12704  167 ARHE 170
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
606-802 1.47e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.38  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  606 VEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKvtEELTAATAQVSRLQLKVTAHQKKE--AELQMQLTESLKETDLL 683
Cdd:COG4717   316 LEEEELEELLAALGLPPDLSPEELLELLDRIEELQ--ELLREAEELEEELQLEELEQEIAAllAEAGVEDEEELRAALEQ 393

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  684 KGQLIKLQAELSELQETSEQAQSKFK--SEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERkkKSAQERCRAEEEI 761
Cdd:COG4717   394 AEEYQELKEELEELEEQLEELLGELEelLEALDEEELEEELEELEEELEELEEELEELREELAEL--EAELEQLEEDGEL 471

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 961710477  762 DEIRKSYQEELDKLRQLLKKARVstDQAAAEQLSLVQAELQ 802
Cdd:COG4717   472 AELLQELEELKAELRELAEEWAA--LKLALELLEEAREEYR 510
PLN02939 PLN02939
transferase, transferring glycosyl groups
 515-793 1.52e-05

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 49.52  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  515 HNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSLLLPSMSVTMETSMI---------MGNIQRIIQENERLKQEILEKS 585
Cdd:PLN02939   97 HNRASMQRDEAIAAIDNEQQTNSKDGEQLSDFQLEDLVGMIQNAEKNILllnqarlqaLEDLEKILTEKEALQGKINILE 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  586 SRIEEQNDKIsELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELTAATAQVSRLQLKVTAHQKK 665
Cdd:PLN02939  177 MRLSETDARI-KLAAQEKIHVEILEEQLEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAELIEVAET 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  666 EAELQMQLTE-SLKETDL--LKGQLIKLQAELSELQ--------ETSEQAQ-----SKFKSEK-----QSRRQLELKVTS 724
Cdd:PLN02939  256 EERVFKLEKErSLLDASLreLESKFIVAQEDVSKLSplqydcwwEKVENLQdlldrATNQVEKaalvlDQNQDLRDKVDK 335

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 961710477  725 LEEELADLRAEKESLEK-NLSERKKKSAQERC-RAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQ 793
Cdd:PLN02939  336 LEASLKEANVSKFSSYKvELLQQKLKLLEERLqASDHEIHSYIQLYQESIKEFQDTLSKLKEESKKRSLEH 406
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 572-754 1.71e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 49.18  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  572 QENERLKQEILEKSSRIEEQNDKI---SELIERNQRYVEQSNLMMEKRNNSLqtaTENTQARVLHAEQEKAKVTEELTAA 648
Cdd:COG3096   934 EQFEQLQADYLQAKEQQRRLKQQIfalSEVVQRRPHFSYEDAVGLLGENSDL---NEKLRARLEQAEEARREAREQLRQA 1010

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  649 TAQVS----RLQLKVTAHQKKEAELQmQLTESLKEtdllkgqlIKLQAElselQETSEQAQSKFKSEKQSRRQLELKVTS 724
Cdd:COG3096  1011 QAQYSqynqVLASLKSSRDAKQQTLQ-ELEQELEE--------LGVQAD----AEAEERARIRRDELHEELSQNRSRRSQ 1077

                         170       180       190
                  ....*....|....*....|....*....|
gi 961710477  725 LEEELADLRAEKESLEKNLSERKKKSAQER 754
Cdd:COG3096  1078 LEKQLTRCEAEMDSLQKRLRKAERDYKQER 1107
CAGE1 pfam15066
Cancer-associated gene protein 1 family; CAGE-1 is a family of proteins overexpressed in ...
 588-754 2.04e-05

Cancer-associated gene protein 1 family; CAGE-1 is a family of proteins overexpressed in tumour tissues compared with surrounding tissues. CAGE-1 gene showed testis-specific expression among normal tissues and displayed wide expression in a variety of cancer cell lines and cancer tissues. CAGE-1 is predominantly expressed during post-meiotic stages. It localizes to the acrosomal matrix and acrosomal granule showing it to be a component of the acrosome of mammalian spermatids and spermatozoa.


Pssm-ID: 464481  Cd Length: 528  Bit Score: 48.68  E-value: 2.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   588 IEEQNDKISELIErnqryvEQSNLMMEKR--NNSLQTATE---NTQARVLHAEQEKAKVTEELTAATAQVSRLQLK-VTA 661
Cdd:pfam15066  365 INKLKENVEELIE------DKYNVILEKNdiNKTLQNLQEilaNTQKHLQESRKEKETLQLELKKIKVNYVHLQERyITE 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   662 HQKKEAE----LQMQLTESLKEtdllkGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELkvtSLEEELAdlRAEKE 737
Cdd:pfam15066  439 MQQKNKSvsqcLEMDKTLSKKE-----EEVERLQQLKGELEKATTSALDLLKREKETREQEFL---SLQEEFQ--KHEKE 508

                          170
                   ....*....|....*...
gi 961710477   738 SLEknlsERKK-KSAQER 754
Cdd:pfam15066  509 NLE----ERQKlKSRLEK 522
mukB PRK04863
chromosome partition protein MukB;
587-785 2.42e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 48.80  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  587 RIEEQNDKISEL------IERNQRYVEQsnlmMEKRNNSLQTATEN---TQARVLHAEQEKAKVTEELTAATAQVSRLql 657
Cdd:PRK04863  895 RVEEIREQLDEAeeakrfVQQHGNALAQ----LEPIVSVLQSDPEQfeqLKQDYQQAQQTQRDAKQQAFALTEVVQRR-- 968

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  658 kvtAHQKKEAELQMqLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKF----------KSEKQSRRQLelkVTSLEE 727
Cdd:PRK04863  969 ---AHFSYEDAAEM-LAKNSDLNEKLRQRLEQAEQERTRAREQLRQAQAQLaqynqvlaslKSSYDAKRQM---LQELKQ 1041

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 961710477  728 ELADL------------RAEKESLEKNLSE-RKKKSAQERCRA--EEEIDEIRK---SYQEELDKLRQLLKKARVS 785
Cdd:PRK04863 1042 ELQDLgvpadsgaeeraRARRDELHARLSAnRSRRNQLEKQLTfcEAEMDNLTKklrKLERDYHEMREQVVNAKAG 1117
PRK09039 PRK09039
peptidoglycan -binding protein;
577-735 2.66e-05

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 47.65  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  577 LKQEILEKSSRIEEQNDKISELIERnqryveqsnLMMEKRNN-SLQTATENTQARVLHAEQEKAKVTEELTAATAQVSRL 655
Cdd:PRK09039   44 LSREISGKDSALDRLNSQIAELADL---------LSLERQGNqDLQDSVANLRASLSAAEAERSRLQALLAELAGAGAAA 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  656 QLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKsEKQSR-----RQLELKVTSLEEELA 730
Cdd:PRK09039  115 EGRAGELAQELDSEKQVSARALAQVELLNQQIAALRRQLAALEAALDASEKRDR-ESQAKiadlgRRLNVALAQRVQELN 193


                  ....*
gi 961710477  731 DLRAE 735
Cdd:PRK09039  194 RYRSE 198
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
518-787 2.69e-05

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 47.60  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  518 EIRMAVSKVADKMDHLMTKV----EELQKHSAgnslllpsmsvtmETSMIMGNIQRIIQENERLKQEILEKSSRIEEQN- 592
Cdd:COG1340    33 ELNEELKELAEKRDELNAQVkelrEEAQELRE-------------KRDELNEKVKELKEERDELNEKLNELREELDELRk 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  593 ------------DKISELIERNQRYVEQSNLMMEKRNNSLQTATEntQARVLHAEQEKAKVTEELTAATAQVSRLQLKVT 660
Cdd:COG1340   100 elaelnkaggsiDKLRKEIERLEWRQQTEVLSPEEEKELVEKIKE--LEKELEKAKKALEKNEKLKELRAELKELRKEAE 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  661 AHQKKEAELQMQLTEslketdlLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLe 740
Cdd:COG1340   178 EIHKKIKELAEEAQE-------LHEEMIELYKEADELRKEADELHKEIVEAQEKADELHEEIIELQKELRELRKELKKL- 249

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 961710477  741 knlseRKKKSAQERCRAEEEIDEIRKsyqEELDKLRqllKKARVSTD 787
Cdd:COG1340   250 -----RKKQRALKREKEKEELEEKAE---EIFEKLK---KGEKLTTE 285
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 686-869 2.96e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.84  E-value: 2.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  686 QLIKLQAELSELQETseqaqskfkseKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAqercRAEEEIDEIR 765
Cdd:COG1579     8 ALLDLQELDSELDRL-----------EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIK----RLELEIEEVE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  766 ksyqEELDKLRQLLKKARvstdqaAAEQLSLVQAELqtqweakcehllASAKDEhllqyqevcaqRDASQQELLRLQEKC 845
Cdd:COG1579    73 ----ARIKKYEEQLGNVR------NNKEYEALQKEI------------ESLKRR-----------ISDLEDEILELMERI 119

                         170       180
                  ....*....|....*....|....
gi 961710477  846 LALQAQVTALTEQNEQHTKDLENK 869
Cdd:COG1579   120 EELEEELAELEAELAELEAELEEK 143
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 550-868 3.25e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 48.43  E-value: 3.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   550 LLPSMSVTMETSMImgniqRIIQENERLKQEILEKSSRIEEQ--NDKISELIERNQryvEQSNLMMEKRNNSLQTA-TEN 626
Cdd:TIGR00618  172 LFPLDQYTQLALME-----FAKKKSLHGKAELLTLRSQLLTLctPCMPDTYHERKQ---VLEKELKHLREALQQTQqSHA 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   627 TQARVLHAEQEKAKVTEELTAATAQVSRL--QLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQET---- 700
Cdd:TIGR00618  244 YLTQKREAQEEQLKKQQLLKQLRARIEELraQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKmrsr 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   701 -----SEQAQSKFKSEKQSRRQLELKVTSLEEELADlRAEKESLEKnlserkkksaQERCRAEEEIDEIRKsYQEELDKL 775
Cdd:TIGR00618  324 akllmKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRD-AHEVATSIR----------EISCQQHTLTQHIHT-LQQQKTTL 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   776 RQLLKKARVSTDQAAAEQlslVQAELQTQWEAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTAL 855
Cdd:TIGR00618  392 TQKLQSLCKELDILQREQ---ATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSL 468

                          330
                   ....*....|...
gi 961710477   856 TEQNEQhTKDLEN 868
Cdd:TIGR00618  469 KEREQQ-LQTKEQ 480
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
 671-780 3.36e-05

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 47.03  E-value: 3.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  671 MQLTESLKEtdlLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKS 750
Cdd:COG4026   131 NELREELLE---LKEKIDEIAKEKEKLTKENEELESELEELREEYKKLREENSILEEEFDNIKSEYSDLKSRFEELLKKR 207

                          90       100       110
                  ....*....|....*....|....*....|
gi 961710477  751 AQERCRAEEEIDEIrksYQEELDKLRQLLK 780
Cdd:COG4026   208 LLEVFSLEELWKEL---FPEELPEEDFIYF 234
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
567-777 3.57e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 48.37  E-value: 3.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  567 IQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNL-MMEKRNNSLQTATENTQAR----------VLHAE 635
Cdd:COG4913   612 LAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYsWDEIDVASAEREIAELEAElerldassddLAALE 691

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  636 QEKAKVTEELTAATAQVSRLqlkvtahQKKEAELQMQLTESLKETDLLKGQLikLQAELSELQETSEQAQSKFKSEKQSR 715
Cdd:COG4913   692 EQLEELEAELEELEEELDEL-------KGEIGRLEKELEQAEEELDELQDRL--EAAEDLARLELRALLEERFAAALGDA 762

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 961710477  716 RQLELKvTSLEEELADLRAEKESLEKNLsERKKKSAQERCRAE-----EEIDEIRkSYQEELDKLRQ 777
Cdd:COG4913   763 VERELR-ENLEERIDALRARLNRAEEEL-ERAMRAFNREWPAEtadldADLESLP-EYLALLDRLEE 826
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 634-870 4.13e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 48.04  E-value: 4.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   634 AEQEKAKVTEELTAATAQVS------RLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSK 707
Cdd:pfam02463  170 KKKEALKKLIEETENLAELIidleelKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDE 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   708 fksekQSRRQLELKVTSLEEELADLRAEKESLEknlsERKKKSAQERcraEEEIDEIRKSYQEELDKLRQLLKKARvstD 787
Cdd:pfam02463  250 -----QEEIESSKQEIEKEEEKLAQVLKENKEE----EKEKKLQEEE---LKLLAKEEEELKSELLKLERRKVDDE---E 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   788 QAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLRL--------QEKCLALQAQVTALTEQN 859
Cdd:pfam02463  315 KLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLeqleeellAKKKLESERLSSAAKLKE 394

                          250
                   ....*....|.
gi 961710477   860 EQHTKDLENKS 870
Cdd:pfam02463  395 EELELKSEEEK 405
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 575-858 4.27e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 48.02  E-value: 4.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  575 ERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLmMEKRNNSL-------QTATENTQARVLHAEQ-----EKAK-- 640
Cdd:COG3096   350 ERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEA-AEEEVDSLksqladyQQALDVQQTRAIQYQQavqalEKARal 428

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  641 ----------VTEELTAATAQV-----------SRLQLKVTAHQKKEAELQM------------------QLTESLKETD 681
Cdd:COG3096   429 cglpdltpenAEDYLAAFRAKEqqateevleleQKLSVADAARRQFEKAYELvckiageversqawqtarELLRRYRSQQ 508

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  682 LLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTS---LEEELADLRAEKESLEKNLSErkkkSAQERCRAE 758
Cdd:COG3096   509 ALAQRLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAaeeLEELLAELEAQLEELEEQAAE----AVEQRSELR 584

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  759 EEIDEIRKsyqeeldKLRQLLKKARV-STDQAAAEQLS-----------LVQAELQTQWEAkcEHLLASAKDehllqyqE 826
Cdd:COG3096   585 QQLEQLRA-------RIKELAARAPAwLAAQDALERLReqsgealadsqEVTAAMQQLLER--EREATVERD-------E 648

                         330       340       350
                  ....*....|....*....|....*....|..
gi 961710477  827 VCAQRDASQQELLRLQEKCLALQAQVTALTEQ 858
Cdd:COG3096   649 LAARKQALESQIERLSQPGGAEDPRLLALAER 680
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 663-784 4.41e-05

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 47.77  E-value: 4.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  663 QKKEAELQMQLTESLKETDLL-KGQLIKLQAELSELQETSEQAQSKFKSEKQsrrqLELKVTSLEEELADLRAEKESLEK 741
Cdd:COG0542   417 ERRLEQLEIEKEALKKEQDEAsFERLAELRDELAELEEELEALKARWEAEKE----LIEEIQELKEELEQRYGKIPELEK 492

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  742 NLSERKKKSAQERCRAEEEIDE--------------IRKSYQEELDKLRQL---LKKaRV 784
Cdd:COG0542   493 ELAELEEELAELAPLLREEVTEediaevvsrwtgipVGKLLEGEREKLLNLeeeLHE-RV 551
PspA COG1842
Phage shock protein A [Transcription, Signal transduction mechanisms];
634-801 6.58e-05

Phage shock protein A [Transcription, Signal transduction mechanisms];


Pssm-ID: 441447 [Multi-domain]  Cd Length: 217  Bit Score: 45.59  E-value: 6.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  634 AEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLK--ETDLLK---GQLIKLQAELSELQETSEQAQskf 708
Cdd:COG1842    35 MEEDLVEARQALAQVIANQKRLERQLEELEAEAEKWEEKARLALEkgREDLARealERKAELEAQAEALEAQLAQLE--- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  709 ksekQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKkksAQERCR----------AEEEIDEIRKSYQEELDK---L 775
Cdd:COG1842   112 ----EQVEKLKEALRQLESKLEELKAKKDTLKARAKAAK---AQEKVNealsgidsddATSALERMEEKIEEMEARaeaA 184

                         170       180
                  ....*....|....*....|....*.
gi 961710477  776 RQLLKKARVSTDQAAAEQLSLVQAEL 801
Cdd:COG1842   185 AELAAGDSLDDELAELEADSEVEDEL 210
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
571-776 7.45e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 46.96  E-value: 7.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  571 IQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQsnlmmEKRNNSLQTATENTQARVLHAEQEKAKVTEELTAATA 650
Cdd:PRK02224  470 IEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEA-----EDRIERLEERREDLEELIAERRETIEEKRERAEELRE 544

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  651 QVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAE------LSELQETSEQAQSKFKSEKQSRRQLELKVTS 724
Cdd:PRK02224  545 RAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERieslerIRTLLAAIADAEDEIERLREKREALAELNDE 624

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 961710477  725 LEEELADLRAEKESLEKNLSERKKKSAQE-RCRAEEEIDEIrksyQEELDKLR 776
Cdd:PRK02224  625 RRERLAEKRERKRELEAEFDEARIEEAREdKERAEEYLEQV----EEKLDELR 673
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
517-777 7.77e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 46.96  E-value: 7.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  517 TEIRMAVSKVADKMDHLMTKVEEL-QKHSAGNSLllpsmsVTMETsmimgNIQRIIQENERLKQEILEKSSRIEEQNDKI 595
Cdd:PRK02224  471 EEDRERVEELEAELEDLEEEVEEVeERLERAEDL------VEAED-----RIERLEERREDLEELIAERRETIEEKRERA 539

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  596 SELIERNQRYVEQsnlMMEKRN--NSLQTATENTQARVLHAEQEKAKVTEELTA-------------ATAQVSRLQLKvt 660
Cdd:PRK02224  540 EELRERAAELEAE---AEEKREaaAEAEEEAEEAREEVAELNSKLAELKERIESlerirtllaaiadAEDEIERLREK-- 614

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  661 ahQKKEAELQMQLTESLKETDLLKGQLiklQAELSElqETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLE 740
Cdd:PRK02224  615 --REALAELNDERRERLAEKRERKREL---EAEFDE--ARIEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVE 687

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 961710477  741 KNLSER-----KKKSAQERCRAEE----EIDEIRKSYQEELDKLRQ 777
Cdd:PRK02224  688 NELEELeelreRREALENRVEALEalydEAEELESMYGDLRAELRQ 733
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 625-911 8.35e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 47.09  E-value: 8.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   625 ENTQARvlhaEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQL---TESLKETDLLKGQLIKLQAELSE----L 697
Cdd:pfam01576    5 EEMQAK----EEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLqaeTELCAEAEEMRARLAARKQELEEilheL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   698 QETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRA--EKESLEKNLSERKKKSAQERCRAEEEideirksYQEELDKL 775
Cdd:pfam01576   81 ESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAarQKLQLEKVTTEAKIKKLEEDILLLED-------QNSKLSKE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   776 RQLLKK--ARVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLLQyQEVCAQRDASQQELLRLQEKCLALQAQVT 853
Cdd:pfam01576  154 RKLLEEriSEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGR-QELEKAKRKLEGESTDLQEQIAELQAQIA 232

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 961710477   854 ALTEQNEQHTKDLEN-KSHMSGVAAAATDPSEKVKKIMNQVFQsLRGEFELEESYNGRA 911
Cdd:pfam01576  233 ELRAQLAKKEEELQAaLARLEEETAQKNNALKKIRELEAQISE-LQEDLESERAARNKA 290
TACC_C pfam05010
Transforming acidic coiled-coil-containing protein (TACC), C-terminal; This entry represents a ...
 643-782 1.01e-04

Transforming acidic coiled-coil-containing protein (TACC), C-terminal; This entry represents a C-terminal domain found in the the proteins TACC 1, 2 and 3 (TACC1-3). TACC1 is found concentrated in the centrosomes of eukaryotes which may play a conserved role in organizing centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumour suppressor (AZU-1). TACC 3 from Xenopus laevis, also known as maskin, associates XMAP215 and promotes efficient microtubule elongation during mitosis. Maskin is also found to bind CPEB and elF-4E. Interestingly, the functional homolog (Alp7) in Schizosaccharomyces pombe (not included in this entry) has been shown to be required for organization of bipolar spindles.


Pssm-ID: 461517 [Multi-domain]  Cd Length: 201  Bit Score: 44.67  E-value: 1.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   643 EELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQsrrQLELKV 722
Cdd:pfam05010    8 AALEKARNEIEEKELEINELKAKYEELRRENLEMRKIVAEFEKTIAQMIEEKQKQKELEHAEIQKVLEEKD---QALADL 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   723 TSLEEELADL--RAE--KESLE--KNLSERKKKSAQERC----------------------RAEEEIDEIRKSYQEELDK 774
Cdd:pfam05010   85 NSVEKSFSDLfkRYEkqKEVISgyKKNEESLKKCAQDYLarikkeeqryqalkahaeekldQANEEIAQVRSKAKAETAA 164


                   ....*...
gi 961710477   775 LRQLLKKA 782
Cdd:pfam05010  165 LQASLRKE 172
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 607-861 1.33e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 46.10  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   607 EQSNLMMEKRNNSLQTATentqarVLHAEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTEslketdllkgq 686
Cdd:pfam15709  287 EESQVSIDGRSSPTQTFV------VTGNMESEEERSEEDPSKALLEKREQEKASRDRLRAERAEMRRLE----------- 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   687 likLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEE--LADLRAEKESLEKNLSERKK----KSAQERCRAEEE 760
Cdd:pfam15709  350 ---VERKRREQEEQRRLQQEQLERAEKMREELELEQQRRFEEirLRKQRLEEERQRQEEEERKQrlqlQAAQERARQQQE 426

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   761 idEIRKSYQEeldkLRQllKKARVSTDQAAAEQLSlvQAELQTQWEAKCEHLLASAKDEHL--LQYQEVCAQRDASQQEL 838
Cdd:pfam15709  427 --EFRRKLQE----LQR--KKQQEEAERAEAEKQR--QKELEMQLAEEQKRLMEMAEEERLeyQRQKQEAEEKARLEAEE 496

                          250       260
                   ....*....|....*....|...
gi 961710477   839 LRLQEKCLALQAQVTALTEQNEQ 861
Cdd:pfam15709  497 RRQKEEEAARLALEEAMKQAQEQ 519
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 514-740 1.40e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 46.26  E-value: 1.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   514 QHNTEIRMAVSKVADkmdhlmTKVEELQKHSAGNSLLLPSMSVTMETSMIMGNIQ-------RIIQENERLKQEILEKSS 586
Cdd:pfam15921  615 KKDAKIRELEARVSD------LELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKtsrnelnSLSEDYEVLKRNFRNKSE 688

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   587 RIEEQNDKISELIERNQRYVEQSNlmmekrnNSLQTaTENTQArvlHAEQEKAKVTEELTAATAQVSRLQLKVTAhqkke 666
Cdd:pfam15921  689 EMETTTNKLKMQLKSAQSELEQTR-------NTLKS-MEGSDG---HAMKVAMGMQKQITAKRGQIDALQSKIQF----- 752

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 961710477   667 aeLQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELadlraEKESLE 740
Cdd:pfam15921  753 --LEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVAL-----DKASLQ 819
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
689-783 1.41e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 46.00  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  689 KLQAELSELQETSEQAQSKFKSEKQSR-RQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRK- 766
Cdd:COG2433   388 KELPEEEPEAEREKEHEERELTEEEEEiRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEERREIRKDREi 467

                          90
                  ....*....|....*...
gi 961710477  767 -SYQEELDKLRQLLKKAR 783
Cdd:COG2433   468 sRLDREIERLERELEEER 485
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 559-777 1.44e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 45.29  E-value: 1.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   559 ETSMIMGNIQRIIQENERLKQEILEKSSRIEEQNDKISEL-IERNQRYVEQS---NLMMEKRNNSLQTATENTQARVLHA 634
Cdd:pfam13868   99 EREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEqAEWKELEKEEEreeDERILEYLKEKAEREEEREAEREEI 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   635 EQEKAKVTEELTAATAQVS---------RLQLKVTAHQKKEAELQMQLTESLKEtdllkgQLIKLQAELSELQETSEQAQ 705
Cdd:pfam13868  179 EEEKEREIARLRAQQEKAQdekaerdelRAKLYQEEQERKERQKEREEAEKKAR------QRQELQQAREEQIELKERRL 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   706 SKFKSEKQSRRQLELKVTSLEEELADLRAEK---------ESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLR 776
Cdd:pfam13868  253 AEEAEREEEEFERMLRKQAEDEEIEQEEAEKrrmkrlehrRELEKQIEEREEQRAAEREEELEEGERLREEEAERRERIE 332


                   .
gi 961710477   777 Q 777
Cdd:pfam13868  333 E 333
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 623-783 1.49e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.08  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  623 ATENTQARVLHAEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSE 702
Cdd:COG1196   666 SRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEE 745

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  703 QAQSKfksEKQSRRQLELKVTSLEEELADLRAEKESLEK-NLserkkksaqercRAEEEIDEIRKSYqEELDKLRQLLKK 781
Cdd:COG1196   746 ELLEE---EALEELPEPPDLEELERELERLEREIEALGPvNL------------LAIEEYEELEERY-DFLSEQREDLEE 809


                  ..
gi 961710477  782 AR 783
Cdd:COG1196   810 AR 811
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 567-874 1.52e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 46.26  E-value: 1.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   567 IQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELt 646
Cdd:pfam15921  269 IEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIEEL- 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   647 aataqvsrlqlkvtahQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQL-------E 719
Cdd:pfam15921  348 ----------------EKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLwdrdtgnS 411

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   720 LKVTSLEEELADLRAEKESLEKNLS----------ERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKK--ARVSTD 787
Cdd:pfam15921  412 ITIDHLRRELDDRNMEVQRLEALLKamksecqgqmERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEEltAKKMTL 491

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   788 QAAAEQLSLVQAELQTQWEA--KCEHLLASAKDEHLLQYQEVcaQRDASQQELLR-LQEKCLALQAQVTALTEQNEQHTK 864
Cdd:pfam15921  492 ESSERTVSDLTASLQEKERAieATNAEITKLRSRVDLKLQEL--QHLKNEGDHLRnVQTECEALKLQMAEKDKVIEILRQ 569

                          330
                   ....*....|
gi 961710477   865 DLENKSHMSG 874
Cdd:pfam15921  570 QIENMTQLVG 579
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 567-754 1.52e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  567 IQRIIQENERLKQEILEKSSRIEEQNDKISEL---IERNQRYVEQSNLMMEKRNNSLQT--ATENTQARVLHAeqekakv 641
Cdd:COG3883    39 LDALQAELEELNEEYNELQAELEALQAEIDKLqaeIAEAEAEIEERREELGERARALYRsgGSVSYLDVLLGS------- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  642 tEELTAATAQVSRLQlKVTAHQKKEAELQMQLTESLKET-DLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLEL 720
Cdd:COG3883   112 -ESFSDFLDRLSALS-KIADADADLLEELKADKAELEAKkAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSA 189

                         170       180       190
                  ....*....|....*....|....*....|....
gi 961710477  721 KVTSLEEELADLRAEKESLEKNLSERKKKSAQER 754
Cdd:COG3883   190 EEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAA 223
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 672-880 1.52e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  672 QLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKK--- 748
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARaly 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  749 ---------------KSAQERCRAEEEIDEIRKSYQEELDKLRQLlkKARVSTDQAAAEQLSLVQAELQTQWEAKcEHLL 813
Cdd:COG3883    97 rsggsvsyldvllgsESFSDFLDRLSALSKIADADADLLEELKAD--KAELEAKKAELEAKLAELEALKAELEAA-KAEL 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 961710477  814 ASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQNEQHTKDLENKSHMSGVAAAAT 880
Cdd:COG3883   174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 240
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 194-261 1.55e-04

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 42.78  E-value: 1.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 961710477  194 VEVGDSLEVAYTSWLLQnhvlGQVLDSTANKDKLLrLKLGSGKVIKAWEDGMLGMKKGGKRLLVIPPA 261
Cdd:COG1047     1 IEKGDVVTLHYTLKLED----GEVFDSTFEGEPLE-FLHGAGQLIPGLEEALEGMEVGDKKTVTLPPE 63
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 628-776 1.60e-04

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 43.77  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   628 QARVLHAEQEKakvteeLTAATAQVSRLQLKVTAHQKKEAELQMQLTESlketdllkgQLIKLQAELSELQETSEQAQSK 707
Cdd:pfam08614   15 RTALLEAENAK------LQSEPESVLPSTSSSKLSKASPQSASIQSLEQ---------LLAQLREELAELYRSRGELAQR 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 961710477   708 FKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERkkksaqercraEEEIDEIRKSY---QEELDKLR 776
Cdd:pfam08614   80 LVDLNEELQELEKKLREDERRLAALEAERAQLEEKLKDR-----------EEELREKRKLNqdlQDELVALQ 140
CENP-F_leu_zip pfam10473
Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Cenp-F, a centromeric kinetochore, ...
 664-802 1.60e-04

Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway. There are several leucine-rich repeats along the sequence of LEK1 that are considered to be zippers, though they do not appear to be binding DNA directly in this instance.


Pssm-ID: 463102 [Multi-domain]  Cd Length: 140  Bit Score: 43.05  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   664 KKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQ----------SKFKSEKQSRRQlelKVTSLEEELADLR 733
Cdd:pfam10473    3 KKQLHVLEKLKESERKADSLKDKVENLERELEMSEENQELAIleaenskaevETLKAEIEEMAQ---NLRDLELDLVTLR 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 961710477   734 AEKESLEKNLSERKkksaqercraeEEIDEIRKSyQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQ 802
Cdd:pfam10473   80 SEKENLTKELQKKQ-----------ERVSELESL-NSSLENLLEEKEQEKVQMKEESKTAVEMLQTQLK 136
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 586-804 1.67e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  586 SRIEEQNDKISELIERNQRYVEQSNLMMEKRNnSLQTATENTQARVLHAEQEKAKVTEELTAATAQVSRLQ--LKVTAHQ 663
Cdd:COG3883    16 PQIQAKQKELSELQAELEAAQAELDALQAELE-ELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERReeLGERARA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  664 KKEAELQMQLTESLKE----TDLLKGQLI---------KLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELA 730
Cdd:COG3883    95 LYRSGGSVSYLDVLLGsesfSDFLDRLSAlskiadadaDLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELE 174

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 961710477  731 DLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQTQ 804
Cdd:COG3883   175 AQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAG 248
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 572-803 1.73e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 45.98  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  572 QENERLKQEILEKSSRIEEQNDKISELIERN----QRYVEQSNLMMEKRNNSLQTATENT--QARV------LHAEQEKA 639
Cdd:PTZ00440  560 KLKRSMKNDIKNKIKYIEENVDHIKDIISLNdeidNIIQQIEELINEALFNKEKFINEKNdlQEKVkyilnkFYKGDLQE 639

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  640 KVTEELTAATAQVSRLQlkvTAHQKKEaeLQMQLTESLKETDLLK-------GQLIK-LQAELSELQETSEQAQSKF--- 708
Cdd:PTZ00440  640 LLDELSHFLDDHKYLYH---EAKSKED--LQTLLNTSKNEYEKLEfmksdniDNIIKnLKKELQNLLSLKENIIKKQlnn 714

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  709 --KSEKQSRRQLELKVTSLEEELADLRAEKESLE---KNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKAR 783
Cdd:PTZ00440  715 ieQDISNSLNQYTIKYNDLKSSIEEYKEEEEKLEvykHQIINRKNEFILHLYENDKDLPDGKNTYEEFLQYKDTILNKEN 794

                         250       260
                  ....*....|....*....|..
gi 961710477  784 VSTDQAAA--EQLSLVQAELQT 803
Cdd:PTZ00440  795 KISNDINIlkENKKNNQDLLNS 816
DUF4515 pfam14988
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ...
 669-861 1.95e-04

Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.


Pssm-ID: 405647 [Multi-domain]  Cd Length: 206  Bit Score: 43.99  E-value: 1.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   669 LQMQLTESLKETDLLKGQLIKlqaELSELQETSEQAQSKFKSEKQS-RRQLELKvtslEEELADLRAEKESLEkNLSERK 747
Cdd:pfam14988    9 LAKKTEEKQKKIEKLWNQYVQ---ECEEIERRRQELASRYTQQTAElQTQLLQK----EKEQASLKKELQALR-PFAKLK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   748 KKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQT-QWEAKCEHLLASAKDEHLLQYQE 826
Cdd:pfam14988   81 ESQEREIQDLEEEKEKVRAETAEKDREAHLQFLKEKALLEKQLQELRILELGERATrELKRKAQALKLAAKQALSEFCRS 160

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 961710477   827 VCAQRDASQQELLRLQEKCLALQAQVTALTEQNEQ 861
Cdd:pfam14988  161 IKRENRQLQKELLQLIQETQALEAIKSKLENRKQR 195
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 571-851 2.03e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 44.91  E-value: 2.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   571 IQENERLKQEILEKSSRIEEQNDKisELIERNQRYVEQSNLMMEKRNNSLQTA----TENTQARVL---HAEQEKAKVTE 643
Cdd:pfam13868   28 IAEKKRIKAEEKEEERRLDEMMEE--ERERALEEEEEKEEERKEERKRYRQELeeqiEEREQKRQEeyeEKLQEREQMDE 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   644 ELTAATAQVSRLQLKvtaHQKKEAELQMQLTESLKETDLLKGQLIKLQAE--------LSELQETSEQAQSKFKSEKQSR 715
Cdd:pfam13868  106 IVERIQEEDQAEAEE---KLEKQRQLREEIDEFNEEQAEWKELEKEEEREederileyLKEKAEREEEREAEREEIEEEK 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   716 RQLELKVTSLEEELADLRAEKESL------EKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDkLRQLLKKARVSTDQA 789
Cdd:pfam13868  183 EREIARLRAQQEKAQDEKAERDELraklyqEEQERKERQKEREEAEKKARQRQELQQAREEQIE-LKERRLAEEAEREEE 261

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 961710477   790 AAEQLSLVQAELQTQW---EAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQ 851
Cdd:pfam13868  262 EFERMLRKQAEDEEIEqeeAEKRRMKRLEHRRELEKQIEEREEQRAAEREEELEEGERLREEEAE 326
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 568-806 2.38e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 45.43  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  568 QRIIQENERLkqeiLEKSSRIEEQNDK---ISELIER-NQRYVEQSNLM--MEKRNNSLQTAT---ENTQARVLHAEQ-- 636
Cdd:PRK10929  109 QEILQVSSQL----LEKSRQAQQEQDRareISDSLSQlPQQQTEARRQLneIERRLQTLGTPNtplAQAQLTALQAESaa 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  637 EKAKVTE----ELTAATAQ-VSRLQLKVtaHQKKEAELQMQLT---------------ESLKETDLLK---GQL------ 687
Cdd:PRK10929  185 LKALVDElelaQLSANNRQeLARLRSEL--AKKRSQQLDAYLQalrnqlnsqrqreaeRALESTELLAeqsGDLpksiva 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  688 -IKLQAELSelQETSEQAQSKFKSEKQSRR------QLELKVTSLEEE---LADLRAEKESLEKNLS---ERKKKSAQER 754
Cdd:PRK10929  263 qFKINRELS--QALNQQAQRMDLIASQQRQaasqtlQVRQALNTLREQsqwLGVSNALGEALRAQVArlpEMPKPQQLDT 340

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 961710477  755 CRAEEEIDEIRksYQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQTQWE 806
Cdd:PRK10929  341 EMAQLRVQRLR--YEDLLNKQPQLRQIRQADGQPLTAEQNRILDAQLRTQRE 390
Casc1_N pfam15927
Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...
 726-812 2.38e-04

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.


Pssm-ID: 464947 [Multi-domain]  Cd Length: 201  Bit Score: 43.50  E-value: 2.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   726 EEELADLRAEKEslEKNLSERKKKSAQERCRAEEEiDEIRKsyqEELDKLRQLLKKARvstdqAAAEQLSLVqAELQTQW 805
Cdd:pfam15927    5 EEEEERLRAEEE--EAERLEEERREEEEEERLAAE-QDRRA---EELEELKHLLEERK-----EALEKLRAE-AREEAEW 72


                   ....*....
gi 961710477   806 E--AKCEHL 812
Cdd:pfam15927   73 EryMRCDGL 81
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
 568-840 2.50e-04

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 44.36  E-value: 2.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   568 QRIIQENERLKQEILEKSSRieeqndkiseliernqryveqsnlmmekrnNSLQTATENTqARVLHAEQEKAKVTEELTA 647
Cdd:pfam09787   17 ARILQSKEKLIASLKEGSGV------------------------------EGLDSSTALT-LELEELRQERDLLREEIQK 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   648 ATAQVSRLQlkvtahqkkeaeLQMQLTESlketdllkgqliKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEE 727
Cdd:pfam09787   66 LRGQIQQLR------------TELQELEA------------QQQEEAESSREQLQELEEQLATERSARREAEAELERLQE 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   728 EladLRAEKESLeknlsERKKKSAQERCRAEEeideirksyqEELDKLR-QLLKKARVSTDQAAAE----QL--SLVQAe 800
Cdd:pfam09787  122 E---LRYLEEEL-----RRSKATLQSRIKDRE----------AEIEKLRnQLTSKSQSSSSQSELEnrlhQLteTLIQK- 182

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 961710477   801 lQTQWEAkcehlLASAKDEHLLQYQEVCAQRDASQQELLR 840
Cdd:pfam09787  183 -QTMLEA-----LSTEKNSLVLQLERMEQQIKELQGEGSN 216
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
656-825 2.51e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 45.14  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  656 QLKVTAHQKKEAELQMQLTESLKETD-LLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLra 734
Cdd:COG4717   348 ELQELLREAEELEEELQLEELEQEIAaLLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEAL-- 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  735 EKESLEKNLSERKKKSAqercRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQTQWEAK--CEHL 812
Cdd:COG4717   426 DEEELEEELEELEEELE----ELEEELEELREELAELEAELEQLEEDGELAELLQELEELKAELRELAEEWAALklALEL 501

                         170
                  ....*....|...
gi 961710477  813 LASAKDEHLLQYQ 825
Cdd:COG4717   502 LEEAREEYREERL 514
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
567-772 2.77e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.44  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  567 IQRIIQENERLKQEILEKS-SRIEEQNDKISELIERNQRYVEQSNLMMEKRNNslqtatentqarvlhaEQEKAKVTEEL 645
Cdd:PRK03918  565 LDELEEELAELLKELEELGfESVEELEERLKELEPFYNEYLELKDAEKELERE----------------EKELKKLEEEL 628

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  646 TAATAQVSRLQLKVTAHQKKEAELQMQLTEslKETDLLKGQLIKLQAELSELQEtseqaqsKFKSEKQSRRQLELKVTSL 725
Cdd:PRK03918  629 DKAFEELAETEKRLEELRKELEELEKKYSE--EEYEELREEYLELSRELAGLRA-------ELEELEKRREEIKKTLEKL 699

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 961710477  726 EEELADLRAEKESLEK---------NLSER-KKKSAQERCRAEEEIDEIRKSYQEEL 772
Cdd:PRK03918  700 KEELEEREKAKKELEKlekalerveELREKvKKYKALLKERALSKVGEIASEIFEEL 756
FPP pfam05911
Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant ...
 580-754 3.06e-04

Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant proteins that are filament-like. It interacts with the nuclear envelope-associated protein, MAF1, the WPP family pfam13943.


Pssm-ID: 461778 [Multi-domain]  Cd Length: 859  Bit Score: 45.05  E-value: 3.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   580 EILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATEN---TQARVLHAEQEKAKVTEELtaATAQVSrlq 656
Cdd:pfam05911  664 EIPSDGPLVSGSNDLKTEENKRLKEEFEQLKSEKENLEVELASCTENlesTKSQLQESEQLIAELRSEL--ASLKES--- 738

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   657 lkvtahqKKEAELQMQ-LTESLKETDLlkgQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELAdlRAE 735
Cdd:pfam05911  739 -------NSLAETQLKcMAESYEDLET---RLTELEAELNELRQKFEALEVELEEEKNCHEELEAKCLELQEQLE--RNE 806

                          170       180
                   ....*....|....*....|
gi 961710477   736 KESLEKNL-SERKKKSAQER 754
Cdd:pfam05911  807 KKESSNCDaDQEDKKLQQEK 826
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 713-823 3.09e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 45.20  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  713 QSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDK-LRQLLKKARVSTDQAAA 791
Cdd:PRK00409  527 ELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEAQQAIKEAKKEADEiIKELRQLQKGGYASVKA 606

                          90       100       110
                  ....*....|....*....|....*....|..
gi 961710477  792 EQLSLVQAELQTQWEAKCEHLLASAKDEHLLQ 823
Cdd:PRK00409  607 HELIEARKRLNKANEKKEKKKKKQKEKQEELK 638
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 553-936 3.46e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 45.11  E-value: 3.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   553 SMSvTMETSMIMGNIQRIIQEnerLKQEILEKSSRIEEQNDKISELIERNQRYVEQsnLMMEKRNNSLQTATENtqarvl 632
Cdd:pfam15921  209 SMS-TMHFRSLGSAISKILRE---LDTEISYLKGRIFPVEDQLEALKSESQNKIEL--LLQQHQDRIEQLISEH------ 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   633 haEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKEtdlLKGQLIKLQAELSELQETSEQ--------- 703
Cdd:pfam15921  277 --EVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSD---LESTVSQLRSELREAKRMYEDkieelekql 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   704 --AQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLS---ERKKKSAQERCRAEEEIDEIRKSYQE---ELDKL 775
Cdd:pfam15921  352 vlANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSlekEQNKRLWDRDTGNSITIDHLRRELDDrnmEVQRL 431

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   776 RQLLKKARVSTDQAAAEQLSLVQAelqtqweakcehllasaKDEHLLQYQEVCAQRDASQQELLRLQEKclaLQAQVTAL 855
Cdd:pfam15921  432 EALLKAMKSECQGQMERQMAAIQG-----------------KNESLEKVSSLTAQLESTKEMLRKVVEE---LTAKKMTL 491

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   856 tEQNEQHTKDLENKSHMSGVAAAATDpsEKVKKIMNQV------FQSLRGEFE-----------LEESYNGR-AVLGTIM 917
Cdd:pfam15921  492 -ESSERTVSDLTASLQEKERAIEATN--AEITKLRSRVdlklqeLQHLKNEGDhlrnvqteceaLKLQMAEKdKVIEILR 568

                          410
                   ....*....|....*....
gi 961710477   918 NTIKMVTlQLLNQHEQDKG 936
Cdd:pfam15921  569 QQIENMT-QLVGQHGRTAG 586
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 517-787 3.68e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 44.50  E-value: 3.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   517 TEIRMAVSKVADKMDHLMTKVEELQKHSAGNSLLLPSMSVTMETSMIM--GNIQRIiQENERLKQEILEKSSRIEEQNDK 594
Cdd:pfam07888   76 RELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQraAHEARI-RELEEDIKTLTQRVLERETELER 154

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   595 ISELIER--NQRYVEQSnlmmEKRNnsLQTATENTQA--RVLHAEQEKAKVTEELTAATAQ-----VSRLQLKVTAHQKK 665
Cdd:pfam07888  155 MKERAKKagAQRKEEEA----ERKQ--LQAKLQQTEEelRSLSKEFQELRNSLAQRDTQVLqlqdtITTLTQKLTTAHRK 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   666 EAE----------LQMQLTESLKETDLLKGQL----------------IKLQA-----ELSELQETSEQAQSKFKSEKQS 714
Cdd:pfam07888  229 EAEnealleelrsLQERLNASERKVEGLGEELssmaaqrdrtqaelhqARLQAaqltlQLADASLALREGRARWAQERET 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   715 RRQ-----------LELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSY--------------Q 769
Cdd:pfam07888  309 LQQsaeadkdriekLSAELQRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASLrvaqkekeqlqaekQ 388

                          330
                   ....*....|....*...
gi 961710477   770 EELDKLRQLLKKARVSTD 787
Cdd:pfam07888  389 ELLEYIRQLEQRLETVAD 406
FAM184 pfam15665
Family with sequence similarity 184, A and B; The function of FAM184 is not known.
 514-710 4.02e-04

Family with sequence similarity 184, A and B; The function of FAM184 is not known.


Pssm-ID: 464788 [Multi-domain]  Cd Length: 211  Bit Score: 43.11  E-value: 4.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   514 QHNTEIRMAVSKVADKMDHLMTKVEE---LQKHSAgnslllpsmsvTMETSmimgniqriIQENERLKQEILEK----SS 586
Cdd:pfam15665   22 AHEEEIQQILAETREKILQYKSKIGEeldLKRRIQ-----------TLEES---------LEQHERMKRQALTEfeqyKR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   587 RIEEQNDKISEliERNQRYVEQSNLMMEKRNNSLQTATENTQARVlHAEQEKAKVTEELTAATAQ-VSRLQLKVTAHQKK 665
Cdd:pfam15665   82 RVEERELKAEA--EHRQRVVELSREVEEAKRAFEEKLESFEQLQA-QFEQEKRKALEELRAKHRQeIQELLTTQRAQSAS 158

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 961710477   666 EAELQMQLTESLK-ETDLLKGQLIKLQAELSELQETSEQAQSKFKS 710
Cdd:pfam15665  159 SLAEQEKLEELHKaELESLRKEVEDLRKEKKKLAEEYEQKLSKAQA 204
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 514-868 4.20e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 44.65  E-value: 4.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   514 QHNTEIRMAVSKVADKMDHLMTKVEELQKHSAGNSLLLPSMSVTMEtsMIMGNIQRIIQE-------NERLKQEILEKSS 586
Cdd:TIGR00606  688 QTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAP--GRQSIIDLKEKEipelrnkLQKVNRDIQRLKN 765

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   587 RIEEQNDKISEL----------------IERNQRYVEQSNLMMEKRNNSLQTAteNTQARVLHAEQEKAKVTEELTAATA 650
Cdd:TIGR00606  766 DIEEQETLLGTImpeeesakvcltdvtiMERFQMELKDVERKIAQQAAKLQGS--DLDRTVQQVNQEKQEKQHELDTVVS 843

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   651 QVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQlelkVTSLEEELA 730
Cdd:TIGR00606  844 KIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQ----DSPLETFLE 919

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   731 DLRAEKESLEKNLSERKKKSAQERCRAEEEIDEI---RKSYQEELD--KLRQLL-KKARVSTDQAAAEQLSLVQAELQTQ 804
Cdd:TIGR00606  920 KDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIhgyMKDIENKIQdgKDDYLKqKETELNTVNAQLEECEKHQEKINED 999

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 961710477   805 WEAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTaLTEQNEQHTKDLEN 868
Cdd:TIGR00606 1000 MRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQ-VLQMKQEHQKLEEN 1062
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 569-862 4.58e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 44.35  E-value: 4.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   569 RIIQ-ENERLKQEILEKSSRIEEQNdKISELIERNQRYVEqsnlmmekRNNSLQTATENTQarvlhaEQEKAKvtEELTA 647
Cdd:pfam05557   10 RLSQlQNEKKQMELEHKRARIELEK-KASALKRQLDRESD--------RNQELQKRIRLLE------KREAEA--EEALR 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   648 ATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDL-LKGQLIKLQ--------------AELSELQETSEQAQSKFKSEK 712
Cdd:pfam05557   73 EQAELNRLKKKYLEALNKKLNEKESQLADAREVIScLKNELSELRrqiqraelelqstnSELEELQERLDLLKAKASEAE 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   713 QSRRQLELKVTSL---EEELADLRAEKESLEKNLSERKK-KSAQERC--------RAEEEIDEIRKS------YQEELDK 774
Cdd:pfam05557  153 QLRQNLEKQQSSLaeaEQRIKELEFEIQSQEQDSEIVKNsKSELARIpelekeleRLREHNKHLNENienkllLKEEVED 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   775 LRQLLKKARVSTDQAAAEQLSL--VQAELQtQWE----AKCEHL----LASAKDEHLLQYQEVCAQR------DASQQEL 838
Cdd:pfam05557  233 LKRKLEREEKYREEAATLELEKekLEQELQ-SWVklaqDTGLNLrspeDLSRRIEQLQQREIVLKEEnssltsSARQLEK 311

                          330       340
                   ....*....|....*....|....*.
gi 961710477   839 LR--LQEKCLALQAQVTALTEQNEQH 862
Cdd:pfam05557  312 ARreLEQELAQYLKKIEDLNKKLKRH 337
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 568-860 4.70e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 44.35  E-value: 4.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   568 QRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVE--------QSNLM----MEK-------RNNSLQTATENTQ 628
Cdd:pfam05557  145 KAKASEAEQLRQNLEKQQSSLAEAEQRIKELEFEIQSQEQdseivknsKSELAripeLEKelerlreHNKHLNENIENKL 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   629 ARVLHAEQEKAKVtEELTAATAQVSRLQLKVTahqKKEAELQ------MQLTESLKETDLLKGQLIKLQaelselQETSE 702
Cdd:pfam05557  225 LLKEEVEDLKRKL-EREEKYREEAATLELEKE---KLEQELQswvklaQDTGLNLRSPEDLSRRIEQLQ------QREIV 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   703 QAQSKFKSEKQSRrQLELKVTSLEEELADLRAEKESLEKNLSERK--KKSAQERCR-AEEEID---EIRKSYQEEL---D 773
Cdd:pfam05557  295 LKEENSSLTSSAR-QLEKARRELEQELAQYLKKIEDLNKKLKRHKalVRRLQRRVLlLTKERDgyrAILESYDKELtmsN 373

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   774 KLRQLLKKARVSTD--QAAAEQLSLVQAEL-QTQWEAKCEHLLASAKDEHL--LQYQEVCAQRDASQQELLRLQEKCLAL 848
Cdd:pfam05557  374 YSPQLLERIEEAEDmtQKMQAHNEEMEAQLsVAEEELGGYKQQAQTLERELqaLRQQESLADPSYSKEEVDSLRRKLETL 453

                          330
                   ....*....|..
gi 961710477   849 QAQVTALTEQNE 860
Cdd:pfam05557  454 ELERQRLREQKN 465
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
726-867 5.31e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.52  E-value: 5.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  726 EEELADLRAEKESLEKNLSErkkksAQERCraeEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAeqlslvQAELQtQW 805
Cdd:COG4913   609 RAKLAALEAELAELEEELAE-----AEERL---EALEAELDALQERREALQRLAEYSWDEIDVASA------EREIA-EL 673

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 961710477  806 EAKCEHLLASAKDehLLQYQEvcaQRDASQQELLRLQEKCLALQAQVTALTEQNEQHTKDLE 867
Cdd:COG4913   674 EAELERLDASSDD--LAALEE---QLEELEAELEELEEELDELKGEIGRLEKELEQAEEELD 730
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 514-745 5.41e-04

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 43.17  E-value: 5.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   514 QHNTEIRMAVSKVAdkMDHLMTKVEELQKHSAGNSlllpsmsvtmetsmimGNIQRIIQENERLKQEILEKSSRIEEQND 593
Cdd:pfam06008   35 ENAHKIQIEILEKE--LSSLAQETEELQKKATQTL----------------AKAQQVNAESERTLGHAKELAEAIKNLID 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   594 KISELIERNQRY-VEQSNLMMEKRNNSLQTAT---ENTQARVLHAEQEKAkvTEELTAATAQVSRLQLKVTAHQKKeael 669
Cdd:pfam06008   97 NIKEINEKVATLgENDFALPSSDLSRMLAEAQrmlGEIRSRDFGTQLQNA--EAELKAAQDLLSRIQTWFQSPQEE---- 170

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 961710477   670 qmqlTESLKETdlLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSE 745
Cdd:pfam06008  171 ----NKALANA--LRDSLAEYEAKLSDLRELLREAAAKTRDANRLNLANQANLREFQRKKEEVSEQKNQLEETLKT 240
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 567-840 5.59e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 43.75  E-value: 5.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   567 IQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRyvEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELT 646
Cdd:pfam13868   78 LEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQEEDQ--AEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDE 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   647 AATAQVSRLQLKVtahQKKEAELQMQLTESLKETDLLKGQL---IKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVT 723
Cdd:pfam13868  156 RILEYLKEKAERE---EEREAEREEIEEEKEREIARLRAQQekaQDEKAERDELRAKLYQEEQERKERQKEREEAEKKAR 232

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   724 SLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKARvstdqaaaeqlslvqAELQT 803
Cdd:pfam13868  233 QRQELQQAREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHR---------------RELEK 297

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 961710477   804 QWEAKCEHLLASAKDEhlLQYQEVCAQRDASQQELLR 840
Cdd:pfam13868  298 QIEEREEQRAAEREEE--LEEGERLREEEAERRERIE 332
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 635-778 5.82e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 43.47  E-value: 5.82e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477    635 EQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTE--SLKETDLLKgqlikLQAELSELQETSEQAQSKFKSEK 712
Cdd:smart00787  157 KEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDEleDCDPTELDR-----AKEKLKKLLQEIMIKVKKLEELE 231

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 961710477    713 QSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAqercraeeeiDEIRKsYQEELDKLRQL 778
Cdd:smart00787  232 EELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTF----------KEIEK-LKEQLKLLQSL 286
growth_prot_Scy NF041483
polarized growth protein Scy;
632-902 5.98e-04

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 44.43  E-value: 5.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  632 LHAEQEKAKVTEELTAATAQVSRLqlkVTAHQKKEAELQMQL-TESLKETDllkgqliKLQAELSELQETSEQ------- 703
Cdd:NF041483   83 IQADQLRADAERELRDARAQTQRI---LQEHAEHQARLQAELhTEAVQRRQ-------QLDQELAERRQTVEShvnenva 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  704 --AQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAqERCRAEEEIDEIRKSYQEEldklrQLLKK 781
Cdd:NF041483  153 waEQLRARTESQARRLLDESRAEAEQALAAARAEAERLAEEARQRLGSEA-ESARAEAEAILRRARKDAE-----RLLNA 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  782 ARVSTDQAA--AEQLSLVQAELQTQWEAKCEHLLASAkdEHLLQYQEVcAQRDASQQELLRLQEKCLALQAQVTALTEQN 859
Cdd:NF041483  227 ASTQAQEATdhAEQLRSSTAAESDQARRQAAELSRAA--EQRMQEAEE-ALREARAEAEKVVAEAKEAAAKQLASAESAN 303

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 961710477  860 EQHTKdlENKSHMSGVAAAATDPSEKVKKIMNQVFQSLRGEFE 902
Cdd:NF041483  304 EQRTR--TAKEEIARLVGEATKEAEALKAEAEQALADARAEAE 344
iSH2_PI3K_IA_R cd12923
Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory ...
 598-752 6.89e-04

Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; PI3Ks catalyze the transfer of the gamma-phosphoryl group from ATP to the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives. They play an important role in a variety of fundamental cellular processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, immune cell activation, and apoptosis. They are classified according to their substrate specificity, regulation, and domain structure. Class IA PI3Ks are heterodimers of a p110 catalytic (C) subunit and a p85-related regulatory (R) subunit. The R subunit down-regulates PI3K basal activity, stabilizes the C subunit, and plays a role in the activation downstream of tyrosine kinases. All R subunits contain two SH2 domains that flank an intervening helical domain (iSH2), which binds to the N-terminal adaptor-binding domain (ABD) of the catalytic subunit. In vertebrates, there are three genes (PIK3R1, PIK3R2, and PIK3R3) that encode for different Class IA PI3K R subunits.


Pssm-ID: 214016 [Multi-domain]  Cd Length: 152  Bit Score: 41.44  E-value: 6.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  598 LIERNQRYVEQSNlMMEKRNNSLQTATENTQAR--VLHAEQEKAKVTEEltaataqvsrlQLKVTAHQKKEAELQ--MQL 673
Cdd:cd12923    10 LKEINKEYLDKSR-EYDELYEKYNKLSQEIQLKrqALEAFEEAVKMFEE-----------QLRTQEKFQKEAQPHekQRL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 961710477  674 TESLKetdllkgqliKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQ 752
Cdd:cd12923    78 MENNE----------LLKSRLKELEESKEQLEEDLRKQVAYNRELEREMNSLKPELMQLRKQKDQYLRWLKRKGVSQEE 146
PTZ00121 PTZ00121
MAEBL; Provisional
 572-774 7.62e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 7.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  572 QENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQsnLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELTAATAQ 651
Cdd:PTZ00121 1615 AEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEE--LKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAE 1692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  652 vsrlQLKVTAHQKKEAE-LQMQLTESLKETDLLKgqliklqaelselqetSEQAQSKFKSEKQSRRQLELKVTSLEeela 730
Cdd:PTZ00121 1693 ----ALKKEAEEAKKAEeLKKKEAEEKKKAEELK----------------KAEEENKIKAEEAKKEAEEDKKKAEE---- 1748

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 961710477  731 dLRAEKesleknlsERKKKSAQERCRAEEEIDEIRKSY----QEELDK 774
Cdd:PTZ00121 1749 -AKKDE--------EEKKKIAHLKKEEEKKAEEIRKEKeaviEEELDE 1787
Tropomyosin_1 pfam12718
Tropomyosin like; This family is a set of eukaryotic tropomyosins. Within the yeast Tpm1 and ...
 687-812 8.46e-04

Tropomyosin like; This family is a set of eukaryotic tropomyosins. Within the yeast Tpm1 and Tpm2, biochemical and sequence analyses indicate that Tpm2p spans four actin monomers along a filament, whereas Tpm1p spans five. Despite its shorter length, Tpm2p can compete with Tpm1p for binding to F-actin. Over-expression of Tpm2p in vivo alters the axial budding of haploids to a bipolar pattern, and this can be partially suppressed by co-over-expression of Tpm1p. This suggests distinct functions for the two tropomyosins, and indicates that the ratio between them is important for correct morphogenesis. The family also contains higher eukaryote Tpm3 members.


Pssm-ID: 403808 [Multi-domain]  Cd Length: 142  Bit Score: 41.14  E-value: 8.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   687 LIKLQAELSELQETSEQAQSKFKsekqsrrQLELKVTSLEEELADL-------RAEKESLEKNLSERKKK---SAQERCR 756
Cdd:pfam12718    2 MNSLKLEAENAQERAEELEEKVK-------ELEQENLEKEQEIKSLthknqqlEEEVEKLEEQLKEAKEKaeeSEKLKTN 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 961710477   757 A----------EEEIDEIRKSYQEELDKLRQllkkarvsTDQAAAEQLSLVQAELQT--QWEAKCEHL 812
Cdd:pfam12718   75 NenltrkiqllEEELEESDKRLKETTEKLRE--------TDVKAEHLERKVQALEQErdEWEKKYEEL 134
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 572-756 8.62e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 43.40  E-value: 8.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   572 QENERLKQEILEKSSRIEEqndkisELIERNQRYVEQSNLMMEKRNNS--LQTATENTQARVLHAEQEKAKVTEELTAAT 649
Cdd:pfam15709  358 EEQRRLQQEQLERAEKMRE------ELELEQQRRFEEIRLRKQRLEEErqRQEEEERKQRLQLQAAQERARQQQEEFRRK 431

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   650 AQVSRLQLKVTAHQKKEAELQMQlteslKEtdlLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEEL 729
Cdd:pfam15709  432 LQELQRKKQQEEAERAEAEKQRQ-----KE---LEMQLAEEQKRLMEMAEEERLEYQRQKQEAEEKARLEAEERRQKEEE 503

                          170       180
                   ....*....|....*....|....*..
gi 961710477   730 ADLRAEKESleknlserkKKSAQERCR 756
Cdd:pfam15709  504 AARLALEEA---------MKQAQEQAR 521
PTZ00121 PTZ00121
MAEBL; Provisional
 573-888 9.09e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 9.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  573 ENERLKQEILEKSS---RIEE-QNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLHaEQEKAKVTEELTAA 648
Cdd:PTZ00121 1112 EEARKAEEAKKKAEdarKAEEaRKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAK-KAEAARKAEEVRKA 1190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  649 TaQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQsKFKSEKQSRRQLELKVTSLEEE 728
Cdd:PTZ00121 1191 E-ELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAE-EERNNEEIRKFEEARMAHFARR 1268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  729 LADLRAE--------------KESLEKNLSERKKKSAQERCRAEE--EIDEIRKSYQEELDKLRQLLKKARVSTDQAAAE 792
Cdd:PTZ00121 1269 QAAIKAEearkadelkkaeekKKADEAKKAEEKKKADEAKKKAEEakKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA 1348

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  793 qlslvqaelQTQWEAKCEHLLASAKDEHLLQYQEVCAQRDASQQElLRLQEKCLALQAQVTAltEQNEQHTKDLENKSHM 872
Cdd:PTZ00121 1349 ---------KAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAK-KKAEEKKKADEAKKKA--EEDKKKADELKKAAAA 1416

                         330
                  ....*....|....*.
gi 961710477  873 SGVAAAATDPSEKVKK 888
Cdd:PTZ00121 1417 KKKADEAKKKAEEKKK 1432
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 631-858 9.13e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 43.35  E-value: 9.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   631 VLHAEQEKAKVTEELTAATAQVSRLQLK--VTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQEtSEQAQSKF 708
Cdd:pfam07888   45 ELLQAQEAANRQREKEKERYKRDREQWErqRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSE-EKDALLAQ 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   709 KSEKQSR-RQLELKVTSLEEELADLRAEKESLEknlsERKKKSAQERCRAEEEideiRKSYQ-------EELDKLRQLLK 780
Cdd:pfam07888  124 RAAHEARiRELEEDIKTLTQRVLERETELERMK----ERAKKAGAQRKEEEAE----RKQLQaklqqteEELRSLSKEFQ 195

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 961710477   781 KARVSTDQAAAEQLSLVQAELQTQweakceHLLASAkdehllqyQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQ 858
Cdd:pfam07888  196 ELRNSLAQRDTQVLQLQDTITTLT------QKLTTA--------HRKEAENEALLEELRSLQERLNASERKVEGLGEE 259
Jnk-SapK_ap_N pfam09744
JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins ...
 689-777 1.06e-03

JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF pfam00621 domain at their C-terminal end.


Pssm-ID: 462875 [Multi-domain]  Cd Length: 150  Bit Score: 40.68  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   689 KLQAELSELQETSEQAQSKFKSEKQSRRQ----LELKVTSLEEELADLRAEKESLEK-----------NLSERKKKSAQE 753
Cdd:pfam09744   47 EHNVELEELREDNEQLETQYEREKALRKRaeeeLEEIEDQWEQETKDLLSQVESLEEenrrleadhvsRLEEKEAELKKE 126

                           90       100
                   ....*....|....*....|....
gi 961710477   754 RCRAEEEIDEIRKSYQEELDKLRQ 777
Cdd:pfam09744  127 YSKLHERETEVLRKLKEVVDRQRD 150
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
669-858 1.23e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.08  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  669 LQMQLTESLKETDLLKGQLIKLQAELSElqetSEQAQSKFKSEKQS------RRQLELKVTSLEEELADLRAEKESLEKN 742
Cdd:COG3206   166 LELRREEARKALEFLEEQLPELRKELEE----AEAALEEFRQKNGLvdlseeAKLLLQQLSELESQLAEARAELAEAEAR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  743 LSERKKKSAQERCRAEEEI-DEIRKSYQEELDKLRQLLKKARVS-TD-----QAAAEQLSLVQAELQtqweakcehllas 815
Cdd:COG3206   242 LAALRAQLGSGPDALPELLqSPVIQQLRAQLAELEAELAELSARyTPnhpdvIALRAQIAALRAQLQ------------- 308

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 961710477  816 akdehllqyQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQ 858
Cdd:COG3206   309 ---------QEAQRILASLEAELEALQAREASLQAQLAQLEAR 342
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 663-854 1.28e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 42.75  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   663 QKKEAELQMQLTESLKETDLLKGQL-------IKLQAELSELQETSEQAQSKFKSEKQSRRQLEL---KVTSLEEELADL 732
Cdd:pfam05622  303 RERLTELQQLLEDANRRKNELETQNrlanqriLELQQQVEELQKALQEQGSKAEDSSLLKQKLEEhleKLHEAQSELQKK 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   733 RAEKESLEKNLS---ERKKKSAQERCRA-EEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQTQwEAK 808
Cdd:pfam05622  383 KEQIEELEPKQDsnlAQKIDELQEALRKkDEDMKAMEERYKKYVEKAKSVIKTLDPKQNPASPPEIQALKNQLLEK-DKK 461

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 961710477   809 CEHLLASAKDEHLLQYQE------------VCAQRDASQQELLRLQ---EKCLALQAQVTA 854
Cdd:pfam05622  462 IEHLERDFEKSKLQREQEeklivtawynmgMALHRKAIEERLAGLSspgQSFLARQRQATN 522
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 307-499 1.47e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   307 SAAPSPIPGADSLSADPVVSPPTSVPFKSGEPALRIKSnslneqlTVNTNPDTVKAKLISRMAKMgQPMLPILPPQLDSN 386
Cdd:pfam03154  192 TQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHT-------LIQQTPTLHPQRLPSPHPPL-QPMTQPPPPSQVSP 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   387 DSEIEEVntVRGAGQPVATP-SMQPSLQPaHPVLPQMTSQAPQPSVSglQAPsaalmqvasLDSHSAVSGNAQSFQpyag 465
Cdd:pfam03154  264 QPLPQPS--LHGQMPPMPHSlQTGPSHMQ-HPVPPQPFPLTPQSSQS--QVP---------PGPSPAAPGQSQQRI---- 325

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 961710477   466 mqayAYPHASAVTSQLQPAR--PLYPTPLSQsPHFQ 499
Cdd:pfam03154  326 ----HTPPSQSQLQSQQPPReqPLPPAPLSM-PHIK 356
PLN02939 PLN02939
transferase, transferring glycosyl groups
 585-819 1.51e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 42.97  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  585 SSRIEEQNDKISELIERNQRYVEQSNLMMEkrnnSLQTATENTQARVLHAEQEKAKVTEELTAATAQVSRLQLKVTAhqk 664
Cdd:PLN02939  102 MQRDEAIAAIDNEQQTNSKDGEQLSDFQLE----DLVGMIQNAEKNILLLNQARLQALEDLEKILTEKEALQGKINI--- 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  665 keaeLQMQLTESlketdllkGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELK-VTSLEEELADLRAEKESLEKNL 743
Cdd:PLN02939  175 ----LEMRLSET--------DARIKLAAQEKIHVEILEEQLEKLRNELLIRGATEGLcVHSLSKELDVLKEENMLLKDDI 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  744 SERKkksaqercraeEEIDEIRKSYQE--ELDKLRQLLK------KARVSTDQAAAEQLSLVQAELqtqWEAKCE---HL 812
Cdd:PLN02939  243 QFLK-----------AELIEVAETEERvfKLEKERSLLDaslrelESKFIVAQEDVSKLSPLQYDC---WWEKVEnlqDL 308


                  ....*..
gi 961710477  813 LASAKDE 819
Cdd:PLN02939  309 LDRATNQ 315
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 566-771 1.75e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 42.90  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  566 NIQRIIQENERL------KQEILEKSSRIEEQNDKISELIERNQRYV-------EQSNLMMEKRNNSLQTATENTQARVL 632
Cdd:PTZ00440 2378 KLLKNIKRNNTLcnnnniKDFISNIGKSVETIKQRFSSNLPEKEKLHqieenlnEIKNIMNETKRISNVDAFTNKILQDI 2457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  633 HAEQEKAKVTEELTAataqVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEK 712
Cdd:PTZ00440 2458 DNEKNKENNNMNAEK----IDDLIENVTSHNEKIKSELLIINDALRRVKEKKDEMNKLFNSLTENNNNNNNSAKNIVDNS 2533

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  713 QS-RRQLELKVTSLEE-------ELADLRAEKESLEKNL---SERKKKSAQERCRAEEEIDEIRKSYQEE 771
Cdd:PTZ00440 2534 TYiINELESHVSKLNEllsyidnEIKELENEKLKLLEKAkieESRKERERIESETQEDNTDEEQINRQQQ 2603
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 517-863 1.77e-03

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 42.87  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  517 TEIRMAVS-KVADKMDHLMTKVEELQKHSAGNSLLLPSMSVTMETSMimgniQRIIQENERL--KQEILEKSSRIEEQND 593
Cdd:PRK10246  179 TEIYGQISaMVFEQHKSARTELEKLQAQASGVALLTPEQVQSLTASL-----QVLTDEEKQLltAQQQQQQSLNWLTRLD 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  594 KISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVLH------AEQEKA---------KVTEELTAATAQVSRL-QL 657
Cdd:PRK10246  254 ELQQEASRRQQALQQALAAEEKAQPQLAALSLAQPARQLRphweriQEQSAAlahtrqqieEVNTRLQSTMALRARIrHH 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  658 KVTAHQKKEAELQmQLTESLKETDLL--------------------KGQLIKLQAELSELQE------------TSEQAQ 705
Cdd:PRK10246  334 AAKQSAELQAQQQ-SLNTWLAEHDRFrqwnnelagwraqfsqqtsdREQLRQWQQQLTHAEQklnalpaitltlTADEVA 412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  706 SKFKSEKQSRrQLELKVTSLEEELADLRAEKESLEKNLSerkkKSAQERCRAEEEIDEIRKSYQEeldKLRQLLKKARVS 785
Cdd:PRK10246  413 AALAQHAEQR-PLRQRLVALHGQIVPQQKRLAQLQVAIQ----NVTQEQTQRNAALNEMRQRYKE---KTQQLADVKTIC 484

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  786 TDQAAAEQLSLVQAELQTqweAKCEHLLASAKDEHLLQYQEVC-----AQRDASQQELLRLQEKCLALQAQVTALTEQNE 860
Cdd:PRK10246  485 EQEARIKDLEAQRAQLQA---GQPCPLCGSTSHPAVEAYQALEpgvnqSRLDALEKEVKKLGEEGAALRGQLDALTKQLQ 561


                  ...
gi 961710477  861 QHT 863
Cdd:PRK10246  562 RDE 564
FliJ COG2882
Flagellar biosynthesis chaperone FliJ [Cell motility];
615-764 2.11e-03

Flagellar biosynthesis chaperone FliJ [Cell motility];


Pssm-ID: 442129 [Multi-domain]  Cd Length: 142  Bit Score: 39.89  E-value: 2.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  615 KRNNSLQTATEntqarvlHAEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETdLLKGQLIKLQAEL 694
Cdd:COG2882     2 KRSFRLQTLLD-------LAEKEEDEAARELGQAQQALEQAEEQLEQLEQYREEYEQRLQQKLQQG-LSAAQLRNYQQFI 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 961710477  695 SELQETSEQAQSKfksEKQSRRQLELKvtslEEELADLRAEKESLEKnLSERKKKSAQERCRAEE--EIDEI 764
Cdd:COG2882    74 ARLDEAIEQQQQQ---VAQAEQQVEQA----RQAWLEARQERKALEK-LKERRREEERQEENRREqkELDEL 137
DUF4201 pfam13870
Domain of unknown function (DUF4201); This is a family of coiled-coil proteins from eukaryotes. ...
 654-783 2.24e-03

Domain of unknown function (DUF4201); This is a family of coiled-coil proteins from eukaryotes. The function is not known.


Pssm-ID: 464008 [Multi-domain]  Cd Length: 177  Bit Score: 40.28  E-value: 2.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   654 RLQLKVTAHQKKEAELQM----QLTESLKETDLLKgqlikLQAELSELQETSEQaqskfKSEKQSRrqLELKVTSLEEEL 729
Cdd:pfam13870   12 RLELITLKHTLAKIQEKLeqkeELGEGLTMIDFLQ-----LQIENQALNEKIEE-----RNKELKR--LKLKVTNTVHAL 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 961710477   730 ADLRaEKESLEKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKAR 783
Cdd:pfam13870   80 THLK-EKLHFLSAELSRLKKELRERQELLAKLRKELYRVKLERDKLRKQNKKLR 132
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 582-865 2.33e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.47  E-value: 2.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   582 LEKSSR-----IEEQNDKISELiERNQRYVEQSNLMMEKRNNSLQTATE-NTQARVLHAEQEKAKVTEELTAATAQV--S 653
Cdd:pfam01576  683 LERSKRaleqqVEEMKTQLEEL-EDELQATEDAKLRLEVNMQALKAQFErDLQARDEQGEEKRRQLVKQVRELEAELedE 761

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   654 RLQ--LKVTAHQKKEAELQ---MQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEE 728
Cdd:pfam01576  762 RKQraQAVAAKKKLELDLKeleAQIDAANKGREEAVKQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAE 841

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   729 LADLRAEKESleknlSERKKKSAQ-ERCRAEEEIDEIRKSYQEELDKLRQLlkKARVStdqaaaeQLSLVQAELQTQWEA 807
Cdd:pfam01576  842 LLQLQEDLAA-----SERARRQAQqERDELADEIASGASGKSALQDEKRRL--EARIA-------QLEEELEEEQSNTEL 907

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   808 KCEHLLASAKDEHLLQyQEVCAQRDASQ-------------QEL-LRLQE-----------KCLALQAQVTALTEQNEQH 862
Cdd:pfam01576  908 LNDRLRKSTLQVEQLT-TELAAERSTSQksesarqqlerqnKELkAKLQEmegtvkskfksSIAALEAKIAQLEEQLEQE 986


                   ...
gi 961710477   863 TKD 865
Cdd:pfam01576  987 SRE 989
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 652-873 2.46e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 40.66  E-value: 2.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   652 VSRLQLKVTAHQKKEAELQMQLTESLKETDLLKgQLIKLQaelselqetsEQAQSKFKSekqSRRQLELKVTSLEEELAD 731
Cdd:pfam15619    6 LSARLHKIKELQNELAELQSKLEELRKENRLLK-RLQKRQ----------EKALGKYEG---TESELPQLIARHNEEVRV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   732 LRAE---KESLEKNLSERKKKSAQERCRAeeeideirksyQEELDKLRQLLKkarvstDQAAAEQLSLVQ--AELQTQWE 806
Cdd:pfam15619   72 LRERlrrLQEKERDLERKLKEKEAELLRL-----------RDQLKRLEKLSE------DKNLAEREELQKklEQLEAKLE 134

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 961710477   807 AKCEHLLASAKDEHLLQyqevcaqrDASQQELLRLQEKCLALQAQVTALTEQNEQHTKDLENKSHMS 873
Cdd:pfam15619  135 DKDEKIQDLERKLELEN--------KSFRRQLAAEKKKHKEAQEEVKILQEEIERLQQKLKEKEREL 193
PHA03247 PHA03247
large tegument protein UL36; Provisional
 951-1129 2.74e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  951 PRQPSVSGSAGPPPVPlSGEMQGSPSLSPEQAVQEAVPPPPRVlsTPQEEVQGREGEPSEAEALSeieEGSLSPELTCGP 1030
Cdd:PHA03247 2878 PARPPVRRLARPAVSR-STESFALPPDQPERPPQPQAPPPPQP--QPQPPPPPQPQPPPPPPPRP---QPPLAPTTDPAG 2951

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477 1031 SQRALGPPTSVPPMPPGPVLVDSECEETLASAlenPCVEEPESTARlSLTSHLLKGDPLASGSESPGEEPQPP--ELKK- 1107
Cdd:PHA03247 2952 AGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA---PSREAPASSTP-PLTGHSLSRVSSWASSLALHEETDPPpvSLKQt 3027

                         170       180
                  ....*....|....*....|....*...
gi 961710477 1108 ------DEDVTSSAIPYREPGGTEAGSP 1129
Cdd:PHA03247 3028 lwppddTEDSDADSLFDSDSERSDLEAL 3055
Sds3 pfam08598
Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing ...
 682-833 3.27e-03

Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing repressor-co-repressor complexes, which are recruited to promoters of target genes via interactions with sequence-specific transcription factors. The co-repressor complex contains a core of at least seven proteins. This family represents the conserved region found in Sds3, Dep1 and BRMS1-homolog p40 proteins.


Pssm-ID: 430099  Cd Length: 218  Bit Score: 40.42  E-value: 3.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   682 LLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELadlraEKESLEKNLSERKKKSAQERcraEEEI 761
Cdd:pfam08598   19 LYRNKLTALQTELQLLHQGSHPELLQYYRDLEEERDAELKRLRLREEY-----QLKRIDIETKADRTAAHQEF---KKLV 90

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 961710477   762 DEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKdEHLLQYQEVCAQRDA 833
Cdd:pfam08598   91 KLLKEKLYDETTQKIYRLNEERRLLDLANTNSYLVDYKKTRSHTLAGLLNPNFTSR-NNPVDPGELVTDRRS 161
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 624-844 3.28e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  624 TENTQARVLHAEQEKAKvteELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQ 703
Cdd:COG1196   553 VEDDEVAAAAIEYLKAA---KAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVA 629

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  704 AQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERcRAEEEIDEIRKSYQEELDKLRQLLKKAR 783
Cdd:COG1196   630 ARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAE-LEELAERLAEEELELEEALLAEEEEERE 708

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 961710477  784 VSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLLQYQEVCAQ------RDASQQELLRLQEK 844
Cdd:COG1196   709 LAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEElpeppdLEELERELERLERE 775
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
715-871 3.30e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.82  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  715 RRQLELKVTSLEEELADLRAEKESLEKnlserkkksAQERCRAEEEIDEIRKSYQE---ELDKLRQLLKKARVSTDQAAA 791
Cdd:COG4913   220 EPDTFEAADALVEHFDDLERAHEALED---------AREQIELLEPIRELAERYAAareRLAELEYLRAALRLWFAQRRL 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  792 EQLSLVQAELQTQWEAkcehllasakdehlLQyqevcAQRDASQQELLRLQEKCLALQAQ--------VTALTEQNEQHT 863
Cdd:COG4913   291 ELLEAELEELRAELAR--------------LE-----AELERLEARLDALREELDELEAQirgnggdrLEQLEREIERLE 351


                  ....*...
gi 961710477  864 KDLENKSH 871
Cdd:COG4913   352 RELEERER 359
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 655-839 3.33e-03

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 41.66  E-value: 3.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   655 LQLKVTAHQKKEAELqmqLTESLKEtdllkgqLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRA 734
Cdd:pfam07111   53 LELEGSQALSQQAEL---ISRQLQE-------LRRLEEEVRLLRETSLQQKMRLEAQAMELDALAVAEKAGQAEAEGLRA 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   735 E---KESLEKNLSERKKKsaqercraeeEIDEIRKSYQEELDKLRQLLKKArVSTDQAAAEQLSLVQAELQTQWEAKCEH 811
Cdd:pfam07111  123 AlagAEMVRKNLEEGSQR----------ELEEIQRLHQEQLSSLTQAHEEA-LSSLTSKAEGLEKSLNSLETKRAGEAKQ 191

                          170       180
                   ....*....|....*....|....*...
gi 961710477   812 LLASAKDEHLLQYQEVCAQRDASQQELL 839
Cdd:pfam07111  192 LAEAQKEAELLRKQLSKTQEELEAQVTL 219
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 621-782 3.45e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  621 QTATENTQARVLHAEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQET 700
Cdd:COG1196   669 ELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELL 748

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  701 SEQAQSKFKSEkQSRRQLELKVTSLEEELADL-----RAEKESLEknLSERKKKSAQERCRAEEEIDEIRKSyQEELDKL 775
Cdd:COG1196   749 EEEALEELPEP-PDLEELERELERLEREIEALgpvnlLAIEEYEE--LEERYDFLSEQREDLEEARETLEEA-IEEIDRE 824


                  ....*...
gi 961710477  776 -RQLLKKA 782
Cdd:COG1196   825 tRERFLET 832
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 566-861 3.53e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 41.36  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  566 NIQRIIQENERLKQEILEKSsrIEEQNDKISEL---------IER-NQRYVEQSNLMMEKRNNSLQTATE-NTQARVLHA 634
Cdd:PRK04778   26 RNYKRIDELEERKQELENLP--VNDELEKVKKLnltgqseekFEEwRQKWDEIVTNSLPDIEEQLFEAEElNDKFRFRKA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  635 EQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAElQMQLTESLKET------DLL------------------------- 683
Cdd:PRK04778  104 KHEINEIESLLDLIEEDIEQILEELQELLESEEK-NREEVEQLKDLyrelrkSLLanrfsfgpaldelekqlenleeefs 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  684 --------------KGQLIKLQAELSELQETSEQ-------AQSKFKSE----KQSRRQLE-----LKVTSLEEELADLR 733
Cdd:PRK04778  183 qfveltesgdyveaREILDQLEEELAALEQIMEEipellkeLQTELPDQlqelKAGYRELVeegyhLDHLDIEKEIQDLK 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  734 AEKESLEKNLSERKKKSAQERCRA-EEEIDEI----------RKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQ---- 798
Cdd:PRK04778  263 EQIDENLALLEELDLDEAEEKNEEiQERIDQLydilerevkaRKYVEKNSDTLPDFLEHAKEQNKELKEEIDRVKQsytl 342

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 961710477  799 ----AELQTQWEAKCEHLLAsakdehllQYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQNEQ 861
Cdd:PRK04778  343 neseLESVRQLEKQLESLEK--------QYDEITERIAEQEIAYSELQEELEEILKQLEEIEKEQEK 401
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
706-792 3.77e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 40.66  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  706 SKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDEIRKsYQEELDKLRQLLKKARVS 785
Cdd:COG1340     1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQE-LREKRDELNEKVKELKEE 79


                  ....*..
gi 961710477  786 TDQAAAE 792
Cdd:COG1340    80 RDELNEK 86
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 697-809 3.96e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 39.25  E-value: 3.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   697 LQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAE----KESLEKNLSERKKKSAQERCR-AEEEIDEIRKSYQEE 771
Cdd:pfam05672   16 LAEKRRQAREQREREEQERLEKEEEERLRKEELRRRAEEerarREEEARRLEEERRREEEERQRkAEEEAEEREQREQEE 95

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 961710477   772 LDKLRQLLKKARVSTdQAAAEQLSLVQAELQTQWEAKC 809
Cdd:pfam05672   96 QERLQKQKEEAEAKA-REEAERQRQEREKIMQQEEQER 132
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 727-858 4.05e-03

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 38.77  E-value: 4.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   727 EELADLRAEKESLEKNLS--ERKKKSAQERCRAEEEI-DEIRKSYQEELdklrqLLKKARVSTDQAAAEQLSLVQAELQt 803
Cdd:pfam07926    1 AELSSLQSEIKRLKEEAAdaEAQLQKLQEDLEKQAEIaREAQQNYEREL-----VLHAEDIKALQALREELNELKAEIA- 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 961710477   804 QWEAKCEhllaSAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTALTEQ 858
Cdd:pfam07926   75 ELKAEAE----SAKAELEESEESWEEQKKELEKELSELEKRIEDLNEQNKLLHDQ 125
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 597-777 4.21e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 40.95  E-value: 4.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   597 ELIE-RNQRYVEQSNLM-----MEKRNNSLQTATENTQARVLHAEqEKAKVTEeltaataqvsrlqlKVTAHQKKEAElq 670
Cdd:pfam15905  160 ELMKlRNKLEAKMKEVMakqegMEGKLQVTQKNLEHSKGKVAQLE-EKLVSTE--------------KEKIEEKSETE-- 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   671 mQLTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSrrqLELKVTSLEEELADLRAEKESLEknlSERKKKS 750
Cdd:pfam15905  223 -KLLEYITELSCVSEQVEKYKLDIAQLEELLKEKNDEIESLKQS---LEEKEQELSKQIKDLNEKCKLLE---SEKEELL 295

                          170       180       190
                   ....*....|....*....|....*....|...
gi 961710477   751 AQERCRAE------EEIDEIRKSYQEELDKLRQ 777
Cdd:pfam15905  296 REYEEKEQtlnaelEELKEKLTLEEQEHQKLQQ 328
KpsE COG3524
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];
672-803 4.25e-03

Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442746 [Multi-domain]  Cd Length: 370  Bit Score: 40.99  E-value: 4.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  672 QLTESLKETDLLKGQLIKLQAELSELQetseQAQSKFKSEKQSRRQLELkVTSLEEELADLRAEKESLEKNLSERkkkSA 751
Cdd:COG3524   178 AVRFAEEEVERAEERLRDAREALLAFR----NRNGILDPEATAEALLQL-IATLEGQLAELEAELAALRSYLSPN---SP 249

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 961710477  752 QERcRAEEEIDeirkSYQEELDKLRQLLkkarvsTDQAAAEQLSLVQAELQT 803
Cdd:COG3524   250 QVR-QLRRRIA----ALEKQIAAERARL------TGASGGDSLASLLAEYER 290
Rabaptin pfam03528
Rabaptin;
663-867 4.61e-03

Rabaptin;


Pssm-ID: 367545 [Multi-domain]  Cd Length: 486  Bit Score: 40.86  E-value: 4.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   663 QKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQaqsKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEK- 741
Cdd:pfam03528    7 QQRVAELEKENAEFYRLKQQLEAEFNQKRAKFKELYLAKEE---DLKRQNAVLQEAQVELDALQNQLALARAEMENIKAv 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   742 -NLSERKKksaqercraEEEIDEIRKSYQEELDKLRQLLKKarvsTDQAAAEQLSLVQAELQTQWE----------AKCE 810
Cdd:pfam03528   84 aTVSENTK---------QEAIDEVKSQWQEEVASLQAIMKE----TVREYEVQFHRRLEQERAQWNqyresaereiADLR 150

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   811 HLLASAKDEHLLQYQEVCAQRDASqqellRLQEKCLALQAQVTALTE---QNEQHTKDLE 867
Cdd:pfam03528  151 RRLSEGQEEENLEDEMKKAQEDAE-----KLRSVVMPMEKEIAALKAkltEAEDKIKELE 205
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 693-868 4.73e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 40.67  E-value: 4.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   693 ELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEE---IDEIRKSYQ 769
Cdd:pfam13868   32 KRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEreqMDEIVERIQ 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   770 EElDKLRQLLKKARVstdQAAAEQLSLVQAELQTQWEAKCEHLLasAKDEHLLQYQEVCAQRDAS-QQELLRLQEKCLAL 848
Cdd:pfam13868  112 EE-DQAEAEEKLEKQ---RQLREEIDEFNEEQAEWKELEKEEER--EEDERILEYLKEKAEREEErEAEREEIEEEKERE 185

                          170       180
                   ....*....|....*....|
gi 961710477   849 QAQVTALTEQNEQHTKDLEN 868
Cdd:pfam13868  186 IARLRAQQEKAQDEKAERDE 205
Apolipoprotein pfam01442
Apolipoprotein A1/A4/E domain; These proteins contain several 22 residue repeats which form a ...
 640-804 4.85e-03

Apolipoprotein A1/A4/E domain; These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Apolipoprotein A-I. Apolipoprotein A-IV. Apolipoprotein E.


Pssm-ID: 460211 [Multi-domain]  Cd Length: 175  Bit Score: 39.17  E-value: 4.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   640 KVTEELTAATAQVSRLQLKVTAHQKkeaELQMQLTeslKETDLLKGQLiklQAELSELQETSEQAQSKFKSEKQSR-RQL 718
Cdd:pfam01442    1 LLEDSLDELSTYAEELQEQLGPVAQ---ELVDRLE---KETEALRERL---QKDLEEVRAKLEPYLEELQAKLGQNvEEL 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   719 ELKVTSLEEELAD-LRAEKESLEKNLSErkkKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLV 797
Cdd:pfam01442   72 RQRLEPYTEELRKrLNADAEELQEKLAP---YGEELRERLEQNVDALRARLAPYAEELRQKLAERLEELKESLAPYAEEV 148


                   ....*..
gi 961710477   798 QAELQTQ 804
Cdd:pfam01442  149 QAQLSQR 155
Leu_zip pfam15294
Leucine zipper; This family includes Leucine zipper transcription factor-like protein 1 ...
 558-733 5.03e-03

Leucine zipper; This family includes Leucine zipper transcription factor-like protein 1 (LZTFL1) and Leucine zipper protein 2 (LUZP2).


Pssm-ID: 464620 [Multi-domain]  Cd Length: 276  Bit Score: 40.46  E-value: 5.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   558 METSMIMGNIQRIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQtatENTQArvlhaEQE 637
Cdd:pfam15294   98 FEEREFTSSNKKPNFELNKPKLEPLNEGGGSALLHMEIERLKEENEKLKERLKTLESQATQALD---EKSKL-----EKA 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   638 KAKVTEELTAATAQVSRLQlKVTAHQKKEAELQMQLTESLKETDL----LKGQLIKLQAELSELQETSEQAQS----KFk 709
Cdd:pfam15294  170 LKDLQKEQGAKKDVKSNLK-EISDLEEKMAALKSDLEKTLNASTAlqksLEEDLASTKHELLKVQEQLEMAEKelekKF- 247

                          170       180
                   ....*....|....*....|....
gi 961710477   710 SEKQSRRQLELKVTSLEEELADLR 733
Cdd:pfam15294  248 QQTAAYRNMKEMLTKKNEQIKELR 271
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 567-842 5.25e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 40.96  E-value: 5.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   567 IQRIIQENERLKQEILEKSSRIEEQNDKISEL---IERNQRYVEQSNLMME---KRNNSLQTATENTQARVLHAEQ---E 637
Cdd:pfam10174  368 LQDLTEEKSTLAGEIRDLKDMLDVKERKINVLqkkIENLQEQLRDKDKQLAglkERVKSLQTDSSNTDTALTTLEEalsE 447

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   638 KAKVTEeltaataqvsRLQLKvtaHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSElQETS-----EQAQSKFKS-- 710
Cdd:pfam10174  448 KERIIE----------RLKEQ---REREDRERLEELESLKKENKDLKEKVSALQPELTE-KESSlidlkEHASSLASSgl 513

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   711 EKQSR-RQLELKVTSLEEELADLRAE-KESLEKNLSERKKKSAQERCRA-EEEI----DEIRKSyQEELDKLRQLLKKA- 782
Cdd:pfam10174  514 KKDSKlKSLEIAVEQKKEECSKLENQlKKAHNAEEAVRTNPEINDRIRLlEQEVarykEESGKA-QAEVERLLGILREVe 592

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 961710477   783 --RVSTDQ--AAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLLQYQEVCAQRDASQQELLRLQ 842
Cdd:pfam10174  593 neKNDKDKkiAELESLTLRQMKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQ 656
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 568-937 5.32e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 40.98  E-value: 5.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   568 QRIIQENERLKQEILEKSSRIEEQNDKIS------ELIERNQRYVEQSNLmmEKRNNSLQTAtENTQARVLHAEQEKAKV 641
Cdd:pfam12128  290 QLLRTLDDQWKEKRDELNGELSAADAAVAkdrselEALEDQHGAFLDADI--ETAAADQEQL-PSWQSELENLEERLKAL 366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   642 TEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIK--LQAELSELQETSEQAQSKFKSEKQ--SRRQ 717
Cdd:pfam12128  367 TGKHQDVTAKYNRRRSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEddLQALESELREQLEAGKLEFNEEEYrlKSRL 446

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   718 LELK-----VTSLEEELADLRAEKESLEKnLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKA--RVSTDQAA 790
Cdd:pfam12128  447 GELKlrlnqATATPELLLQLENFDERIER-AREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLeeRQSALDEL 525

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   791 AEQLS----LVQAELQTQ---WEAKCEHLLASakdEHLLQYQEVCAQRDASQQELLRLQEKCLALQAqvtalTEQNEQHT 863
Cdd:pfam12128  526 ELQLFpqagTLLHFLRKEapdWEQSIGKVISP---ELLHRTDLDPEVWDGSVGGELNLYGVKLDLKR-----IDVPEWAA 597

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 961710477   864 KDLENKSHMSGVAAAATDPSEKVKKIMNQVFQsLRGEFE---LEESYNGRAVLGTIMNTIKMVTLQllnQHEQDKGQ 937
Cdd:pfam12128  598 SEEELRERLDKAEEALQSAREKQAAAEEQLVQ-ANGELEkasREETFARTALKNARLDLRRLFDEK---QSEKDKKN 670
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 695-906 5.58e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 41.11  E-value: 5.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   695 SELQETSEQAQSKFKSEKQSRRQLELKvtsLEEELADLRAEKESlEKNLSERKKKSAQERCRAEEEI-DEIRKSYQEELD 773
Cdd:pfam02463  165 SRLKRKKKEALKKLIEETENLAELIID---LEELKLQELKLKEQ-AKKALEYYQLKEKLELEEEYLLyLDYLKLNEERID 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   774 KLRQLLKKARVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLLQYQEvcaQRDASQQELLRLQEKCLALQAQVT 853
Cdd:pfam02463  241 LLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAK---EEEELKSELLKLERRKVDDEEKLK 317

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 961710477   854 ALTEQNEQHTKDLENKSHMSGVAAAATDPSEKVKKIMNQVFQSLRGEFELEES 906
Cdd:pfam02463  318 ESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQ 370
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 720-854 5.72e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 40.84  E-value: 5.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  720 LKVTSLEEELADLRAEKESLEKnlserkkksaqERCRAEEEIDEirkSYQEELDKLRQLLKKARvstdqaaaEQLslvqA 799
Cdd:COG0542   404 MEIDSKPEELDELERRLEQLEI-----------EKEALKKEQDE---ASFERLAELRDELAELE--------EEL----E 457

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 961710477  800 ELQTQWEAKCEHL--LASAKDEHLLQYQEVCAQRDASQQELLRLQEKCLALQAQVTA 854
Cdd:COG0542   458 ALKARWEAEKELIeeIQELKEELEQRYGKIPELEKELAELEEELAELAPLLREEVTE 514
F-BAR_PSTPIP cd07647
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine ...
 678-811 6.06e-03

The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Proteins; F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Vetebrates contain two Proline-Serine-Threonine Phosphatase-Interacting Proteins (PSTPIPs), PSTPIP1 and PSTPIP2. PSTPIPs are mainly expressed in hematopoietic cells and are involved in the regulation of cell adhesion and motility. Mutations in PSTPIPs have been shown to cause autoinflammatory disorders. PSTPIP1 contains an N-terminal F-BAR domain, PEST motifs, and a C-terminal SH3 domain, while PSTPIP2 contains only the N-terminal F-BAR domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.


Pssm-ID: 153331 [Multi-domain]  Cd Length: 239  Bit Score: 39.77  E-value: 6.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  678 KETDLLKGQLIKLQAELSELQETSEQAqskFKSEKQSRRQLELKVTSLEEEladlraeKESLEKNLSErKKKSAQERCRA 757
Cdd:cd07647    67 KETENVANAHIQLAQSLREEAEKLEEF---REKQKEERKKTEDIMKRSQKN-------KKELYKKTMK-AKKSYEQKCRE 135

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 961710477  758 EEEIDEIRKS-----YQEELDKLRQLLKKARVSTDQA-AAEQLSLVQAE-LQTQWEAKCEH 811
Cdd:cd07647   136 KDKAEQAYEKsssgaQPKEAEKLKKKAAQCKTSAEEAdSAYKSSIGCLEdARVEWESEHAT 196
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 575-795 6.39e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 40.68  E-value: 6.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  575 ERLKQEI-LEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQARVlhaEQEKAKVTEELTAATAQVS 653
Cdd:PRK05771   34 EDLKEELsNERLRKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIKDV---EEELEKIEKEIKELEEEIS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  654 RLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQA------ELSELQETSEQAQSKFKSEKQSRR-----QLELKV 722
Cdd:PRK05771  111 ELENEIKELEQEIERLEPWGNFDLDLSLLLGFKYVSVFVgtvpedKLEELKLESDVENVEYISTDKGYVyvvvvVLKELS 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 961710477  723 TSLEEELADLRAEKESL--EKNLSERKKKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKAR--VSTDQAAAEQLS 795
Cdd:PRK05771  191 DEVEEELKKLGFERLELeeEGTPSELIREIKEELEEIEKERESLLEELKELAKKYLEELLALYeyLEIELERAEALS 267
Nuf2_DHR10-like pfam18595
Nuf2, DHR10-like domain; This domain is found at the C-terminal region of Nuf2 proteins. This ...
 649-777 6.90e-03

Nuf2, DHR10-like domain; This domain is found at the C-terminal region of Nuf2 proteins. This domain was identified as MazG related domain also designated as Designed helical repeat protein 10 (DHR10) that actually adopts a coiled-coil structure. Nuf2 is part of the Ndc80 complex, which binds to the spindle and is required for chromosome segregation and spindle checkpoint activity.


Pssm-ID: 465814 [Multi-domain]  Cd Length: 117  Bit Score: 37.56  E-value: 6.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   649 TAQVSRLQLKVTAHQKKEAELQMQLtESLK--ETDLlkgqliklqAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLE 726
Cdd:pfam18595    1 SSTLAEEKEELAELERKARELQAKI-DALQvvEKDL---------RSCIKLLEEIEAELAKLEEAKKKLKELRDALEEKE 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 961710477   727 EELADLRAEKESLEKNLSerkkkSAQERC-RAEEEIDEIRKSYQEELDKLRQ 777
Cdd:pfam18595   71 IELRELERREERLQRQLE-----NAQEKLeRLREQAEEKREAAQARLEELRE 117
CENP-H pfam05837
Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H ...
 673-749 7.18e-03

Centromere protein H (CENP-H); This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localization signal. CENP-H is specifically and constitutively localized in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organization and function throughout the cell cycle. This the C-terminus of the region, which is conserved from fungi to humans.


Pssm-ID: 461756 [Multi-domain]  Cd Length: 114  Bit Score: 37.56  E-value: 7.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   673 LTESLKETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELA------DLRAEKESLEKNLSER 746
Cdd:pfam05837    1 LLPLINRRDELSSAILKLSSELRELQEELTEVEKENLRLKRKNRELAAELLELAKEKEsrredpKLRAQLEKLEAELKKS 80


                   ...
gi 961710477   747 KKK 749
Cdd:pfam05837   81 RRR 83
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 634-775 7.38e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 39.12  E-value: 7.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   634 AEQEKAKVTEELTAATAQVSRLQLKVTAHQK-KEA---------ELQMQLTESLKETDLLKGQLIKLQAELSELQETSEQ 703
Cdd:pfam13851   52 IQQENKRLTEPLQKAQEEVEELRKQLENYEKdKQSlknlkarlkVLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEA 131

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 961710477   704 AQS--KFKSEKQSrRQLELKVTSLEEELadlraekESLEKNLSERKKKS---AQERCRAEEEIDEIRKSYQEELDKL 775
Cdd:pfam13851  132 AIQdvQQKTGLKN-LLLEKKLQALGETL-------EKKEAQLNEVLAAAnldPDALQAVTEKLEDVLESKNQLIKDL 200
UPF0242 pfam06785
Uncharacterized protein family (UPF0242) N-terminus; This region includes an N-terminal ...
 694-781 7.60e-03

Uncharacterized protein family (UPF0242) N-terminus; This region includes an N-terminal transmembrane region and a C-terminal coiled-coil.


Pssm-ID: 429117 [Multi-domain]  Cd Length: 194  Bit Score: 39.03  E-value: 7.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   694 LSELQETSEQAQSKfksekqsRRQLELKVTSLEEELADLRAEKESLEKNLSERKKKSAQERCRAEEEIDE---IRKSYQE 770
Cdd:pfam06785   85 FKILEETLEELQSE-------EERLEEELSQKEEELRRLTEENQQLQIQLQQISQDFAEFRLESEEQLAEkqlLINEYQQ 157

                           90
                   ....*....|.
gi 961710477   771 ELDKLRQLLKK 781
Cdd:pfam06785  158 TIEEQRSVLEK 168
PRK01156 PRK01156
chromosome segregation protein; Provisional
 511-857 8.27e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 40.27  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  511 EARQHNTEIRMAVSKVADKMDHLMTKVEELQKhsagNSLLLPSMSVTMETSMIMGNiqriiQENERLKQEILEKSSRIEE 590
Cdd:PRK01156  413 EINVKLQDISSKVSSLNQRIRALRENLDELSR----NMEMLNGQSVCPVCGTTLGE-----EKSNHIINHYNEKKSRLEE 483

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  591 QNDKIseliERNQRYVEQSNLMMEKRNNSLqtatENTQARVLHAEQEKAKVTE-ELTAATAQVSRLQLKVTAHQKKEAEL 669
Cdd:PRK01156  484 KIREI----EIEVKDIDEKIVDLKKRKEYL----ESEEINKSINEYNKIESARaDLEDIKIKINELKDKHDKYEEIKNRY 555

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  670 QMQLTESL--KETDLLKGQLIKLQAELSELQETSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESlEKNLSERK 747
Cdd:PRK01156  556 KSLKLEDLdsKRTSWLNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIEN-EANNLNNK 634

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  748 KKSAQERCRAEEEIDEIRKSYQEELDKLRQLLKKARVSTDQAAAEQLSLVQAELQTQwEAKCEHLLASAKDEHLLQYQEV 827
Cdd:PRK01156  635 YNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALD-DAKANRARLESTIEILRTRINE 713

                         330       340       350
                  ....*....|....*....|....*....|
gi 961710477  828 CAQRDASQQELLRLQEKCLALQAQVTALTE 857
Cdd:PRK01156  714 LSDRINDINETLESMKKIKKAIGDLKRLRE 743
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
663-854 8.78e-03

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 40.06  E-value: 8.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  663 QKKEAELQMQLTESLKETDLLKGQL-----IKLQA----ELSE----------LQETSEQAQSKFKSE--------KQSR 715
Cdd:COG0497   171 KKELEELRADEAERARELDLLRFQLeeleaAALQPgeeeELEEerrrlsnaekLREALQEALEALSGGeggaldllGQAL 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  716 RQLElKVTSLEEELADLRAEKESLEKNLSErkkkSAQE--RCRAEEEIDEIRKSYQEE-LDKLRQLLKKARVSTDQAAAe 792
Cdd:COG0497   251 RALE-RLAEYDPSLAELAERLESALIELEE----AASElrRYLDSLEFDPERLEEVEErLALLRRLARKYGVTVEELLA- 324

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  793 qlslvqaeLQTQWEAKCEHLLASakDEHLLQYQevcAQRDASQQELLRL--------QEKCLALQAQVTA 854
Cdd:COG0497   325 --------YAEELRAELAELENS--DERLEELE---AELAEAEAELLEAaeklsaarKKAAKKLEKAVTA 381
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 561-782 8.88e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 40.38  E-value: 8.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  561 SMIMGNIqrIIQENERLKQEILEKSSRIEEQNDKISELIERNQRYVEQSNLMMEKR--------NNSLQtATENTQARVL 632
Cdd:NF033838   28 SLFLGGV--VHAEEVRGGNNPTVTSSGNESQKEHAKEVESHLEKILSEIQKSLDKRkhtqnvalNKKLS-DIKTEYLYEL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  633 HAEQEKA------KVTEELTAATAQ----VSRLQLKVTAHQKKEAELQMQlTESLKETDLLKGQLI---KLQAELSELQE 699
Cdd:NF033838  105 NVLKEKSeaeltsKTKKELDAAFEQfkkdTLEPGKKVAEATKKVEEAEKK-AKDQKEEDRRNYPTNtykTLELEIAESDV 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  700 TSEQAQSKFKSEKQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKK--KSAQERCRAEEEIDEIRKSYQEELDKLRQ 777
Cdd:NF033838  184 EVKKAELELVKEEAKEPRDEEKIKQAKAKVESKKAEATRLEKIKTDREKaeEEAKRRADAKLKEAVEKNVATSEQDKPKR 263


                  ....*
gi 961710477  778 LLKKA 782
Cdd:NF033838  264 RAKRG 268
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 563-747 9.34e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 40.20  E-value: 9.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  563 IMGNIQRIIQENERLKQEIL--------EKSSRIEEQNDKISELIERN---QRYVEQSN-------LMMEKRNNSLQTAT 624
Cdd:PRK04778  254 IEKEIQDLKEQIDENLALLEeldldeaeEKNEEIQERIDQLYDILEREvkaRKYVEKNSdtlpdflEHAKEQNKELKEEI 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477  625 ENTQA--RVLHAEQEKAK-VTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLKETDLLKGQLIKLQAELSELQETS 701
Cdd:PRK04778  334 DRVKQsyTLNESELESVRqLEKQLESLEKQYDEITERIAEQEIAYSELQEELEEILKQLEEIEKEQEKLSEMLQGLRKDE 413

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 961710477  702 EQAQSK---FKSEKQS-RRQLE-LKVTSLEEELADL----RAEKESLEKNLSERK 747
Cdd:PRK04778  414 LEAREKlerYRNKLHEiKRYLEkSNLPGLPEDYLEMffevSDEIEALAEELEEKP 468
PspA_IM30 pfam04012
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent ...
 634-843 9.42e-03

PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homolog in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.


Pssm-ID: 461130 [Multi-domain]  Cd Length: 215  Bit Score: 38.89  E-value: 9.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   634 AEQEKAKVTEELTAATAQVSRLQLKVTAHQKKEAELQMQLTESLK--ETDLLKGQLIKLQaelsELQETSEQAQSKFKSE 711
Cdd:pfam04012   34 MQSELVKARQALAQTIARQKQLERRLEQQTEQAKKLEEKAQAALTkgNEELAREALAEKK----SLEKQAEALETQLAQQ 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   712 KQSRRQLELKVTSLEEELADLRAEKESLEKNLSERKkksAQErcraeeeideirksyqeeldKLRQLLKKARVSTDQAAA 791
Cdd:pfam04012  110 RSAVEQLRKQLAALETKIQQLKAKKNLLKARLKAAK---AQE--------------------AVQTSLGSLSTSSATDSF 166

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 961710477   792 EQLSLVQAELQTQWEAKCEhlLASAKDEhLLQYQEVCAQRDASQQELLRLQE 843
Cdd:pfam04012  167 ERIEEKIEEREARADAAAE--LASAVDL-DAKLEQAGIQMEVSEDVLARLKA 215
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 684-861 9.46e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 40.21  E-value: 9.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   684 KGQLIKLQAELSELqetsEQAQSKFKSEKQSRRQLELKVTSLEEE----LADLRAEKESLEKNLSERKKKSAQERCRAEE 759
Cdd:pfam12128  240 RPEFTKLQQEFNTL----ESAELRLSHLHFGYKSDETLIASRQEErqetSAELNQLLRTLDDQWKEKRDELNGELSAADA 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961710477   760 EIdeirKSYQEELDKLRQLLK---KARVSTDQAAAEQLSLVQAELQTQ-------------WEAKCEHLLASAKDEHLLQ 823
Cdd:pfam12128  316 AV----AKDRSELEALEDQHGaflDADIETAAADQEQLPSWQSELENLeerlkaltgkhqdVTAKYNRRRSKIKEQNNRD 391

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 961710477   824 YQEVCAQRDASQQELLRLQEKCLA-LQAQVTALTEQNEQ 861
Cdd:pfam12128  392 IAGIKDKLAKIREARDRQLAVAEDdLQALESELREQLEA 430
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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