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Conserved domains on  [gi|959074889|ref|XP_014740986|]
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PREDICTED: kelch-like protein 11 [Sturnus vulgaris]

Protein Classification

kelch-like protein( domain architecture ID 13033017)

kelch-like protein similar to Homo sapiens kelch-like proteins, KLHL11, KLHL12, KLHL17 and KLHL24, which may function as substrate-specific adaptors of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-187 3.07e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 272.12  E-value: 3.07e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  52 FGCPAHCSDLAWRQNEQRRHGLYCDITLAFGGAGmAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGGP 131
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGAG-GREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGP 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 959074889 132 DSDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNC 187
Cdd:cd18241   80 DPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 182-269 2.14e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


:

Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 194.41  E-value: 2.14e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 959074889 262 ERERYFED 269
Cdd:cd18451   81 ERERYFEE 88
PHA03098 super family cl33709
kelch-like protein; Provisional
 74-539 3.88e-41

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 158.01  E-value: 3.88e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  74 YCDITLAFGgAGMAReYRAHRSVLAAATEYFTPLLSGGFAESRsgrVELQKwsseggpDSDTVEAVIGFMYTGTIRVSPG 153
Cdd:PHA03098   9 FCDESIIIV-NGGGI-IKVHKIILSSSSEYFKKMFKNNFKENE---INLNI-------DYDSFNEVIKYIYTGKINITSN 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 154 NVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRD 233
Cdd:PHA03098  77 NVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 234 WLSDSEITVDSEEILFETVLKWVQKNPEERERYFEDLFKLLRlsqmkPTYLTRHV--KSERLVLCNEACVKLVSEAVESH 311
Cdd:PHA03098 157 ILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLR-----ITFLSEEGikKLKRWKLRIKKKKIVFNKRCIKI 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 312 aLRSENLQSGN-----LQHSACPAALLPRFGQNM------------------------------DVIMVIGGVSEGGDYL 356
Cdd:PHA03098 232 -IYSKKYNLNKilprsSTFGSIIYIHITMSIFTYnyitnysplseintiidihyvycfgsvvlnNVIYFIGGMNKNNLSV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 357 SECVGYFIDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA-KTVERYNPNRNIWEQVSNLITRKHSFGLTEVKG 435
Cdd:PHA03098 311 NSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 436 NLYSIGGHGNFSPGFKDVAIYNPEQDKWVNLESAPKILRDVKAVSvEDRFVYVAARTPVDSDSEdgLRAVIIRYDAETRQ 515
Cdd:PHA03098 391 LIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIY-HDGKIYVIGGISYIDNIK--VYNIVESYNPVTNK 467

                        490       500
                 ....*....|....*....|....
gi 959074889 516 WQDVESLplidNYCSFQMSVANTN 539
Cdd:PHA03098 468 WTELSSL----NFPRINASLCIFN 487
Kelch smart00612
Kelch domain;
593-639 3.71e-05

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 3.71e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 959074889   593 VFIIGGWKNSddidkQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 639
Cdd:smart00612   2 IYVVGGFDGG-----QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
 
Name Accession Description Interval E-value
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-187 3.07e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 272.12  E-value: 3.07e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  52 FGCPAHCSDLAWRQNEQRRHGLYCDITLAFGGAGmAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGGP 131
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGAG-GREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGP 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 959074889 132 DSDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNC 187
Cdd:cd18241   80 DPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 182-269 2.14e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 194.41  E-value: 2.14e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 959074889 262 ERERYFED 269
Cdd:cd18451   81 ERERYFEE 88
PHA03098 PHA03098
kelch-like protein; Provisional
 74-539 3.88e-41

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 158.01  E-value: 3.88e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  74 YCDITLAFGgAGMAReYRAHRSVLAAATEYFTPLLSGGFAESRsgrVELQKwsseggpDSDTVEAVIGFMYTGTIRVSPG 153
Cdd:PHA03098   9 FCDESIIIV-NGGGI-IKVHKIILSSSSEYFKKMFKNNFKENE---INLNI-------DYDSFNEVIKYIYTGKINITSN 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 154 NVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRD 233
Cdd:PHA03098  77 NVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 234 WLSDSEITVDSEEILFETVLKWVQKNPEERERYFEDLFKLLRlsqmkPTYLTRHV--KSERLVLCNEACVKLVSEAVESH 311
Cdd:PHA03098 157 ILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLR-----ITFLSEEGikKLKRWKLRIKKKKIVFNKRCIKI 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 312 aLRSENLQSGN-----LQHSACPAALLPRFGQNM------------------------------DVIMVIGGVSEGGDYL 356
Cdd:PHA03098 232 -IYSKKYNLNKilprsSTFGSIIYIHITMSIFTYnyitnysplseintiidihyvycfgsvvlnNVIYFIGGMNKNNLSV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 357 SECVGYFIDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA-KTVERYNPNRNIWEQVSNLITRKHSFGLTEVKG 435
Cdd:PHA03098 311 NSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 436 NLYSIGGHGNFSPGFKDVAIYNPEQDKWVNLESAPKILRDVKAVSvEDRFVYVAARTPVDSDSEdgLRAVIIRYDAETRQ 515
Cdd:PHA03098 391 LIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIY-HDGKIYVIGGISYIDNIK--VYNIVESYNPVTNK 467

                        490       500
                 ....*....|....*....|....
gi 959074889 516 WQDVESLplidNYCSFQMSVANTN 539
Cdd:PHA03098 468 WTELSSL----NFPRINASLCIFN 487
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 187-289 3.68e-32

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 119.96  E-value: 3.68e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  187 CVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPEERERY 266
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 959074889  267 FEDLFKLLRLSQMKPTYLTRHVK 289
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 187-287 5.10e-29

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 110.89  E-value: 5.10e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889   187 CVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPEERERY 266
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 959074889   267 FEDLFKLLRLSQMKPTYLTRH 287
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 66-182 9.52e-27

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 104.65  E-value: 9.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889   66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYT 145
Cdd:pfam00651   2 NELREQGELCDVTLVVGD----KEFRAHKAVLAACSPYFKALFSGQESESSVSEITLD------DVSPEDFEALLEFMYT 71

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 959074889  146 GTIrVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKL 182
Cdd:pfam00651  72 GKL-ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
369-639 1.38e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 98.30  E-value: 1.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 369 WVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA-KTVERYNPNRNIWEQVSNL-ITRKHSFGLTEVKGNLYSIGGHGNF 446
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSAsNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 447 SPG---FKDVAIYNPEQDKWVNLESAPKILRDVKAVSVEDRfVYVAArtpvdSDSEDGLRAVIIRYDAETRQWQDVESLP 523
Cdd:COG3055   83 NPSstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGK-IYVVG-----GWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 524 lidnycsfqmsvaNTNFYHTASCCPKsypidneeakGKI------SSRASDEILESLPPEVLSIEGAAICYYKDDVFIIG 597
Cdd:COG3055  157 -------------TPRDHLAAAVLPD----------GKIlviggrNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFG 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 959074889 598 GwknsddiDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 639
Cdd:COG3055  214 G-------ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAV 248
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 76-182 1.01e-20

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 87.36  E-value: 1.01e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889    76 DITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTIRVSPGNV 155
Cdd:smart00225   1 DVTLVVGG----KKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLD------DVSPEDFRALLNFLYTGKLDLPEENV 70

                           90       100
                   ....*....|....*....|....*..
gi 959074889   156 HEVLEMADRFLLTRLKDFCGEFLKKKL 182
Cdd:smart00225  71 EELLELADYLQIPGLVELCEEFLLKLL 97
Kelch smart00612
Kelch domain;
593-639 3.71e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 3.71e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 959074889   593 VFIIGGWKNSddidkQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 639
Cdd:smart00612   2 IYVVGGFDGG-----QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
Kelch smart00612
Kelch domain;
391-435 2.84e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 2.84e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 959074889   391 VYVAGSMEPG-FAKTVERYNPNRNIWEQVSNLITRKHSFGLTEVKG 435
Cdd:smart00612   2 IYVVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 381-421 4.29e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.36  E-value: 4.29e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 959074889  381 GHAVAVTESYVYVA-GSMEPGFAKTVERYNPNRNIWEQVSNL 421
Cdd:pfam01344   4 GAGVVVVGGKIYVIgGFDGNQSLNSVEVYDPETNTWSKLPSM 45
 
Name Accession Description Interval E-value
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-187 3.07e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 272.12  E-value: 3.07e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  52 FGCPAHCSDLAWRQNEQRRHGLYCDITLAFGGAGmAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGGP 131
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGAG-GREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGP 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 959074889 132 DSDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNC 187
Cdd:cd18241   80 DPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 182-269 2.14e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 194.41  E-value: 2.14e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 959074889 262 ERERYFED 269
Cdd:cd18451   81 ERERYFEE 88
PHA03098 PHA03098
kelch-like protein; Provisional
 74-539 3.88e-41

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 158.01  E-value: 3.88e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  74 YCDITLAFGgAGMAReYRAHRSVLAAATEYFTPLLSGGFAESRsgrVELQKwsseggpDSDTVEAVIGFMYTGTIRVSPG 153
Cdd:PHA03098   9 FCDESIIIV-NGGGI-IKVHKIILSSSSEYFKKMFKNNFKENE---INLNI-------DYDSFNEVIKYIYTGKINITSN 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 154 NVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRD 233
Cdd:PHA03098  77 NVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 234 WLSDSEITVDSEEILFETVLKWVQKNPEERERYFEDLFKLLRlsqmkPTYLTRHV--KSERLVLCNEACVKLVSEAVESH 311
Cdd:PHA03098 157 ILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLR-----ITFLSEEGikKLKRWKLRIKKKKIVFNKRCIKI 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 312 aLRSENLQSGN-----LQHSACPAALLPRFGQNM------------------------------DVIMVIGGVSEGGDYL 356
Cdd:PHA03098 232 -IYSKKYNLNKilprsSTFGSIIYIHITMSIFTYnyitnysplseintiidihyvycfgsvvlnNVIYFIGGMNKNNLSV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 357 SECVGYFIDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA-KTVERYNPNRNIWEQVSNLITRKHSFGLTEVKG 435
Cdd:PHA03098 311 NSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 436 NLYSIGGHGNFSPGFKDVAIYNPEQDKWVNLESAPKILRDVKAVSvEDRFVYVAARTPVDSDSEdgLRAVIIRYDAETRQ 515
Cdd:PHA03098 391 LIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIY-HDGKIYVIGGISYIDNIK--VYNIVESYNPVTNK 467

                        490       500
                 ....*....|....*....|....
gi 959074889 516 WQDVESLplidNYCSFQMSVANTN 539
Cdd:PHA03098 468 WTELSSL----NFPRINASLCIFN 487
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 187-289 3.68e-32

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 119.96  E-value: 3.68e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  187 CVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPEERERY 266
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 959074889  267 FEDLFKLLRLSQMKPTYLTRHVK 289
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 187-287 5.10e-29

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 110.89  E-value: 5.10e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889   187 CVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPEERERY 266
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 959074889   267 FEDLFKLLRLSQMKPTYLTRH 287
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 66-182 9.52e-27

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 104.65  E-value: 9.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889   66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYT 145
Cdd:pfam00651   2 NELREQGELCDVTLVVGD----KEFRAHKAVLAACSPYFKALFSGQESESSVSEITLD------DVSPEDFEALLEFMYT 71

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 959074889  146 GTIrVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKL 182
Cdd:pfam00651  72 GKL-ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 182-316 2.97e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 98.62  E-value: 2.97e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 959074889 262 ERERYFEDLFKLLRLSQMKPTYLTRHVKSERLVLCNEACVKLVSEAVESHaLRSE 316
Cdd:cd18452   81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFH-LRPE 134
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-188 5.02e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 94.86  E-value: 5.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTV 136
Cdd:cd18237    4 LLADFMGVMNNMRKQKTLCDVILIVEG----REIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELK------DAEPDII 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 959074889 137 EAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCV 188
Cdd:cd18237   74 ELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-187 7.95e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 94.43  E-value: 7.95e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTV 136
Cdd:cd18242    4 HAKSILNTMNSLRKSNTLCDVTLRVEG----KEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQ------GLTASTM 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 959074889 137 EAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNC 187
Cdd:cd18242   74 EILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
369-639 1.38e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 98.30  E-value: 1.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 369 WVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA-KTVERYNPNRNIWEQVSNL-ITRKHSFGLTEVKGNLYSIGGHGNF 446
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSAsNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 447 SPG---FKDVAIYNPEQDKWVNLESAPKILRDVKAVSVEDRfVYVAArtpvdSDSEDGLRAVIIRYDAETRQWQDVESLP 523
Cdd:COG3055   83 NPSstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGK-IYVVG-----GWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 524 lidnycsfqmsvaNTNFYHTASCCPKsypidneeakGKI------SSRASDEILESLPPEVLSIEGAAICYYKDDVFIIG 597
Cdd:COG3055  157 -------------TPRDHLAAAVLPD----------GKIlviggrNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFG 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 959074889 598 GwknsddiDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 639
Cdd:COG3055  214 G-------ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAV 248
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-188 2.11e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 93.24  E-value: 2.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYT 145
Cdd:cd18256   12 NKLRGQHEFCDVQLQVGM----ELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIH------GVEPDIFHILLDFIYT 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCV 188
Cdd:cd18256   82 GVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-165 2.40e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 91.46  E-value: 2.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  74 YCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTIRVSPG 153
Cdd:cd18186    1 LCDVTLVVGG----REFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELD------DVSPEAFEALLDYIYTGELELSEE 70

                         90
                 ....*....|..
gi 959074889 154 NVHEVLEMADRF 165
Cdd:cd18186   71 NVEELLAAADKL 82
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-190 7.97e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 89.11  E-value: 7.97e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  50 EEFGCPAHCSDLAWRQNEQRRHGLYCDITL----AFGGAGMAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkw 125
Cdd:cd18273    2 EELEDAAHARALLAQLKSFYDARLLTDVTIevngPGSGPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIH-- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 959074889 126 ssegGPDSDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18273   80 ----DVDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-189 9.16e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 88.12  E-value: 9.16e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGgagmAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWsseggpDSDTVEAVIGFMYT 145
Cdd:cd18238    7 HQFYENGELCDVTLKVG----EKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDI------DEEAVELLVDFAYT 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVA 189
Cdd:cd18238   77 GKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 76-182 1.01e-20

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 87.36  E-value: 1.01e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889    76 DITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTIRVSPGNV 155
Cdd:smart00225   1 DVTLVVGG----KKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLD------DVSPEDFRALLNFLYTGKLDLPEENV 70

                           90       100
                   ....*....|....*....|....*..
gi 959074889   156 HEVLEMADRFLLTRLKDFCGEFLKKKL 182
Cdd:smart00225  71 EELLELADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-187 2.04e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 87.52  E-value: 2.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEggpdsd 134
Cdd:cd18250    2 PAHALHLLRGLSELRAERKFFDVTLCAGG----REFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAE------ 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 959074889 135 TVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNC 187
Cdd:cd18250   72 ILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-179 2.67e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 86.62  E-value: 2.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGR--VELQkwssegGPDSDTVEAVIGFM 143
Cdd:cd18245    6 NSFREEPHLCDATLVVGG----EEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTykIELE------GISVEVMEEILDYI 75

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 959074889 144 YTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLK 179
Cdd:cd18245   76 YTGQIKLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-189 1.38e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 85.21  E-value: 1.38e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEggpdsd 134
Cdd:cd18265    4 PCHAERILQVLNAYRRSGTFTDVVLLVDG----KDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAA------ 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 959074889 135 TVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVA 189
Cdd:cd18265   74 AMEVLLDYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-182 3.92e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 83.63  E-value: 3.92e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSD 134
Cdd:cd18235    2 PQHTQKAFDVMNELRKQNLLCDVILVADGV----EIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQ------DVDGK 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 959074889 135 TVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKL 182
Cdd:cd18235   72 ALLLLIDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQL 119
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-181 6.02e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 82.71  E-value: 6.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYT 145
Cdd:cd18247   11 EEIRRQGKLCDVTLKVGD----QKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQ------GIEPSALEALINFAYS 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKK 181
Cdd:cd18247   81 GRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-194 1.21e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 82.63  E-value: 1.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLafggagMAREYR--AHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGgpdsd 134
Cdd:cd18266    8 HSNLVLQGLNEQRQRGLFCDVVL------VADEQRvpAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIG----- 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 135 tVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAVHSLA 194
Cdd:cd18266   77 -LKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 182-311 2.84e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 81.62  E-value: 2.84e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 959074889 262 ERERYFEDLFKLLRLSQMKPTYLTRHVKSERLVLCNEACVKLVSEAVESH 311
Cdd:cd18512   81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-190 2.94e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 81.15  E-value: 2.94e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSggfaeSRSGRVELQKWSSEGGpDSDTVEAVIGFMYT 145
Cdd:cd18306   10 NALRKNRQFCDVILQVGG----HEIPAHRAVLACASPYLFELFS-----SDSDGESILTVKLDGL-DPDAVEVLVNYAYT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18306   80 SRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 185-294 3.80e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 80.35  E-value: 3.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 185 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPEERE 264
Cdd:cd18445    4 SNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRK 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 959074889 265 RYFEDLFKLLRLSQMKPTYLTRHVKSERLV 294
Cdd:cd18445   84 EHLAELLEHVRLPLLSPEYLVQRVEEEELI 113
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-188 8.48e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 80.26  E-value: 8.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  51 EFGCPAHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKwssegg 130
Cdd:cd18259    9 DFCLPSHPQSILDGLQTLRSNPKLSDVTLLVGG----REFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKD------ 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 959074889 131 PDSDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCV 188
Cdd:cd18259   79 VDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-187 1.15e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 79.29  E-value: 1.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYT 145
Cdd:cd18240    9 NELRLEGKLCDVVIRVNG----VEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIP------GVSPEMMELIIEYAYT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNC 187
Cdd:cd18240   79 RTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
PHA02713 PHA02713
hypothetical protein; Provisional
 73-530 1.45e-17

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 86.60  E-value: 1.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  73 LYCDITLAFGGAgmaREYRAHRSVLAAATEYFTPLLSGGF-AESRSGRVELQKWsseggpDSDTVEAVIGFMYTGTIrvS 151
Cdd:PHA02713  24 ILCDVIITIGDG---EEIKAHKTILAAGSKYFRTLFTTPMiIRDLVTRVNLQMF------DKDAVKNIVQYLYNRHI--S 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 152 PGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAV-HSLAHMYSLnQLALKAQDMIRRNFHKVIQDEEFYTLPFHL 230
Cdd:PHA02713  93 SMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMyHRLYEMSHI-PIVKYIKRMLMSNIPTLITTDAFKKTVFEI 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 231 VRDWLSDSE-ITVDSEEILFETVLKWVQKNpeereryfedlfkllrlsqmkptYLTrhvksERLVLCNEACVKLVSEAVE 309
Cdd:PHA02713 172 LFDIISTNDnVYLYREGYKVTILLKWLEYN-----------------------YIT-----EEQLLCILSCIDIQNLDKK 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 310 SHALRSENlQSGNLqHSACPAALLPRfGQNMDVI-MVIGGVSEGGDY--LSECV-GYFIDEDRWVNLPHIHNHLDGHAVA 385
Cdd:PHA02713 224 SRLLLYSN-KTINM-YPSCIQFLLDN-KQNRNIIpRQLCLVCHDTKYnvCNPCIlVYNINTMEYSVISTIPNHIINYASA 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 386 VTESYVYVAGSM---EPGFAKtVERYNPNRNIWEQVSNLITRKHSFGLTEVKGNLYSIGGHgNFSPGFKDVAIYNPEQDK 462
Cdd:PHA02713 301 IVDNEIIIAGGYnfnNPSLNK-VYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQ-NGTNVERTIECYTMGDDK 378

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 463 WVNLESAPKILRDVkAVSVEDRFVY-------------VAARTPVDSDSEDGLRAVIIRYDAETRQWqdvESLPlidNYC 529
Cdd:PHA02713 379 WKMLPDMPIALSSY-GMCVLDQYIYiiggrtehidytsVHHMNSIDMEEDTHSSNKVIRYDTVNNIW---ETLP---NFW 451


                 .
gi 959074889 530 S 530
Cdd:PHA02713 452 T 452
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 182-288 1.83e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 78.50  E-value: 1.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                         90       100
                 ....*....|....*....|....*..
gi 959074889 262 ERERYFEDLFKLLRLSQMKPTYLTRHV 288
Cdd:cd18457   81 NREEYLPELLSKVRLPLLRPQFLTDRV 107
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-188 3.71e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 78.26  E-value: 3.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWsseggpDSDTVEAVIGFMYT 145
Cdd:cd18249   15 NLLRKHRELCDVVLVVGA----KKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDI------DERAMELLIDFAYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCV 188
Cdd:cd18249   85 SQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-179 4.21e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 77.96  E-value: 4.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLSGGFAESRSGRVelqkwssEGGPD-- 132
Cdd:cd18327    6 PEHSSELLSCLNEQRRAGLLCDLTIKTRGL----EYRTHRAVLAACSLYFRKLFTGGGGGSGDLGA-------GGGQDvc 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 959074889 133 ------SDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLK 179
Cdd:cd18327   75 eldfvgPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-179 4.29e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 77.60  E-value: 4.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGgpdsd 134
Cdd:cd18198    6 PDHSSEILSGLNEQRTQGLLCDVVILVQG----REYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEA----- 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 959074889 135 tVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLK 179
Cdd:cd18198   77 -LTALLEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 182-281 8.03e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 76.32  E-value: 8.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEItVDSEEILFETVLKWVQKNPE 261
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                         90       100
                 ....*....|....*....|
gi 959074889 262 ERERYFEDLFKLLRLSQMKP 281
Cdd:cd18476   80 ARKGYIHDLFKKVRLQYVHP 99
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-182 1.12e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 76.65  E-value: 1.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGAGMAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYT 145
Cdd:cd18248   13 NELRLSQQLCDVTLKVKYQDPKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIE------GVHPCVMSRLIEFAYT 86

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKL 182
Cdd:cd18248   87 ASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 185-276 1.44e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 75.42  E-value: 1.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 185 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPF-HLVRdWLSDSEITVDSEEILFETVLKWVQKNPEER 263
Cdd:cd18448    5 SNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAqHLEK-LISSSDLNVESESQVYEAVMKWVKHDPQHR 83

                         90
                 ....*....|...
gi 959074889 264 ERYFEDLFKLLRL 276
Cdd:cd18448   84 KRHLDDLLSQVRL 96
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-190 2.04e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 75.98  E-value: 2.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  59 SDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEA 138
Cdd:cd18268    8 SELLRQLNSLRQERILTDVILCTGD----KEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLK------GIDSDVLDQ 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 959074889 139 VIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18268   78 IVDYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-178 2.15e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 75.74  E-value: 2.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSseggpdSD 134
Cdd:cd18326    6 PDHSSDILSSLNEQRTQGLLCDVVILVEG----REFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVS------AE 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 959074889 135 TVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFL 178
Cdd:cd18326   76 ALTALLDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-187 4.16e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 74.87  E-value: 4.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTV 136
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVEG----REFPCHRAILSACSSYFRAMFCNDHRESREMLVEIN------GILAEAM 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 959074889 137 EAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNC 187
Cdd:cd18253   71 DCFLQYVYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 182-311 4.72e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 75.10  E-value: 4.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 959074889 262 ERERYFEDLFKLLRLSQMKPTYLTRHVKSERLVLCNEACVKLVSEAVESH 311
Cdd:cd18513   81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 181-284 7.25e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 73.90  E-value: 7.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 181 KLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNP 260
Cdd:cd18444    1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                         90       100
                 ....*....|....*....|....
gi 959074889 261 EERERYFEDLFKLLRLSQMKPTYL 284
Cdd:cd18444   81 PERKKHLAKLLALIRLPLLTPQFL 104
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-183 1.95e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 72.96  E-value: 1.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYT 145
Cdd:cd18257   10 NLLRQHHELCDVVLRVGD----VKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQ------CIDETALQAIVEYAYT 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLN 183
Cdd:cd18257   80 GTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLD 117
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-178 2.81e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 72.61  E-value: 2.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFggagMAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEggpdsd 134
Cdd:cd18328    6 PNHSSEVLCSLNEQRHDGLLCDVVLIV----QDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPE------ 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 959074889 135 TVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFL 178
Cdd:cd18328   76 ALSAILEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-188 2.94e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 72.74  E-value: 2.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwsseggpDS- 133
Cdd:cd18254    3 PSHPDCVLTHLNTLRKQCMFTDVTLWAGN----RSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFH--------DSl 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 959074889 134 --DTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCV 188
Cdd:cd18254   71 hpEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-186 4.89e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 72.31  E-value: 4.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGgagmAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGgpdsdtVEAVIGFMYT 145
Cdd:cd18261   20 NQQRNDGILCDITLVAE----EQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLG------LKQALDFAYT 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSN 186
Cdd:cd18261   90 GQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-187 5.37e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 71.66  E-value: 5.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGAGmareYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGgpdsdtVEAVIGFMYT 145
Cdd:cd18255   10 NALRAKGQLLDVTLIADGQR----FQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKG------LKHILDFAYT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNC 187
Cdd:cd18255   80 SELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 182-289 8.47e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 70.96  E-value: 8.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18446    1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                         90       100
                 ....*....|....*....|....*...
gi 959074889 262 ERERYFEDLFKLLRLSQMKPTYLTRHVK 289
Cdd:cd18446   81 ERLPLLPRVLENVRLPLLDPWYFVETVE 108
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 185-259 9.90e-15

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 69.36  E-value: 9.90e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 959074889 185 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKN 259
Cdd:cd18508    3 TNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-190 1.24e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 71.56  E-value: 1.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  42 AADGDAEAEEFGCPAHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVE 121
Cdd:cd18267    8 ASSGSMNIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGN----RSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVN 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 959074889 122 LQkwsseggpDS---DTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18267   84 FH--------DSihpEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 75-188 1.34e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 70.09  E-value: 1.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  75 CDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTIRVSPGN 154
Cdd:cd18234    2 CDVILIAGD----RRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLK------DVDPDALWTLVQYCYTGRLELKEDN 71

                         90       100       110
                 ....*....|....*....|....*....|....
gi 959074889 155 VHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCV 188
Cdd:cd18234   72 VESLLATACLLQLSEVVEACCGFLMKQLHPSNCL 105
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 182-279 1.41e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 69.79  E-value: 1.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTL-PFHLVRDWLSDSeITVDSEEILFETVLKWVQKNP 260
Cdd:cd18516    1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLsPDELIAIISSDS-LNVEKEEDVFEAVMKWVGKDQ 79

                         90
                 ....*....|....*....
gi 959074889 261 EERERYFEDLFKLLRLSQM 279
Cdd:cd18516   80 EERTKALPVLLESIRFRLM 98
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-187 2.30e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 70.60  E-value: 2.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  54 CPAHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGgpds 133
Cdd:cd18264    8 SKSHGEAVLSQYQSLRAEGFLCDVVLEAEGN----EFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAG---- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 959074889 134 dtVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNC 187
Cdd:cd18264   80 --LQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 182-279 4.70e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 68.26  E-value: 4.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                         90
                 ....*....|....*...
gi 959074889 262 ERERYFEDLFKLLRLSQM 279
Cdd:cd18517   81 NRVKSLGEIFDCIRFRLM 98
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 185-284 6.29e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 68.21  E-value: 6.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 185 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPEERE 264
Cdd:cd18468    3 SNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNRK 82

                         90       100
                 ....*....|....*....|
gi 959074889 265 RYFEDLFKLLRLSQMKPTYL 284
Cdd:cd18468   83 QHIAELLAVVRLPFIHPSYL 102
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-176 7.44e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 68.66  E-value: 7.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  68 QRRHGLYCDITLAFGGAGMAreyrAHRSVLAAATEYFTPLLSGG-FAESRSGRVELQkwssegGPDSDTVEAVIGFMYTG 146
Cdd:cd18293    9 QQNSGVFCDVLLQAEGESVP----AHCCVLSACSPYLTERLSSEpPPAGQKVVLELQ------GLKAHTLLKLVDFLYTS 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 959074889 147 TIRVSPGNVHEVLEMADRFLLTRLKDFCGE 176
Cdd:cd18293   79 ELEVSSEEAQDVLAAARRLQISELESLCLE 108
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-183 7.82e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 68.59  E-value: 7.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAfggaGMAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKwsseggPDSD 134
Cdd:cd18339    2 PAHMKKAFKVMNELRSKQLLCDVTIV----AEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKD------VDGQ 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 959074889 135 TVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLN 183
Cdd:cd18339   72 TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLH 120
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-183 8.92e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 68.17  E-value: 8.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAfggaGMAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKwsseggPDSD 134
Cdd:cd18338    2 PRHMKKAFKVMNELRSQNLLCDVTIV----AEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKE------VDGW 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 959074889 135 TVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLN 183
Cdd:cd18338   72 TLKMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLH 120
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 182-263 9.24e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 66.96  E-value: 9.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                 ..
gi 959074889 262 ER 263
Cdd:cd18480   81 AR 82
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-188 1.03e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 68.46  E-value: 1.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSG-RVELqkwsSEGGPDSDTVEAVIGFMY 144
Cdd:cd18258    9 NQQRRAKEFTDLKIIVEG----KEFEVHQNVLASCSLYFKDLIKRSSRDSGGGeKLEL----TMSNINADVLELLLEFVY 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 959074889 145 TGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCV 188
Cdd:cd18258   81 TGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 182-270 1.66e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 66.55  E-value: 1.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTL-PFHLVrDWLSDSEITVDSEEILFETVLKWVQKNP 260
Cdd:cd18458    2 LDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLsPCQLV-ALISRDELNVRCESEVYNAVIRWVKYDE 80

                         90
                 ....*....|
gi 959074889 261 EERERYFEDL 270
Cdd:cd18458   81 ENRRQYLEAL 90
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 183-270 1.80e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 66.57  E-value: 1.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 183 NLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPEE 262
Cdd:cd18455    1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEE 80


                 ....*...
gi 959074889 263 RERYFEDL 270
Cdd:cd18455   81 RKVHLKDL 88
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 87-174 2.28e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 66.21  E-value: 2.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  87 AREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFL 166
Cdd:cd18314   15 DRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLE------DVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQ 88


                 ....*...
gi 959074889 167 LTRLKDFC 174
Cdd:cd18314   89 VPDLEKLC 96
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 182-260 2.76e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 65.33  E-value: 2.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQD-EEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNP 260
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHDP 80
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-178 2.95e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 66.88  E-value: 2.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  74 YCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTIRVS-- 151
Cdd:cd18287   22 YSDVTFVVEEK----RFPAHRVILAARSEYFRALLYGGMRESQQSEIELK------DTNAEAFKALLKYIYTGRLTLTdl 91

                         90       100
                 ....*....|....*....|....*...
gi 959074889 152 -PGNVHEVLEMADRFLLTRLKDFCGEFL 178
Cdd:cd18287   92 kEDVLLDVLGLAHQYGFEELEAAISDYL 119
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 71-190 4.08e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 66.78  E-value: 4.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  71 HGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKwsseggPDSDTVEAVIGFMYTGTIRV 150
Cdd:cd18340   24 HNKFVDCVLKIKE----KEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLED------VDPDVMGKILHYIYTSEIEI 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 959074889 151 SPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18340   94 TEQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 71-190 5.47e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 66.27  E-value: 5.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  71 HGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKwsseggPDSDTVEAVIGFMYTGTIRV 150
Cdd:cd18269   24 ENKFVDCVLKIGD----KEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLED------VDPDVMGMILKYLYTSEIDL 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 959074889 151 SPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18269   94 NDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 182-276 5.94e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 65.20  E-value: 5.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90
                 ....*....|....*
gi 959074889 262 ERERYFEDLFKLLRL 276
Cdd:cd18460   81 HRQHFWPELLQHVRL 95
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 181-258 6.55e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 64.34  E-value: 6.55e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 959074889 181 KLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQK 258
Cdd:cd18463    1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-178 1.07e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 65.35  E-value: 1.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGGPdsdtv 136
Cdd:cd18278   14 HCTNILLCLNDQRKQDILCDVTLIVEG----KEFRAHRAVLAACSEYFLQALVGQTENDLVVSLPEEVTARGFGP----- 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 959074889 137 eaVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFL 178
Cdd:cd18278   85 --LLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-183 1.29e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 65.44  E-value: 1.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGgagmAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWsseggpDSDTV 136
Cdd:cd18246   22 HYHDAFVSMNRMRQRGLLCDIVLHVG----TKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDI------DPQAL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 959074889 137 EAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLN 183
Cdd:cd18246   92 EQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLD 138
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 88-188 1.44e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 65.26  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  88 REYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLL 167
Cdd:cd18236   34 QEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIK------GVDAETMQILLDYTYTSKVLITKQNVQRVLEAASLFQF 107

                         90       100
                 ....*....|....*....|.
gi 959074889 168 TRLKDFCGEFLKKKLNLSNCV 188
Cdd:cd18236  108 LRMVDACASFLTEALHPENCV 128
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-188 1.56e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 64.85  E-value: 1.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGAGMareYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSD 134
Cdd:cd18252    2 SSHPADFLDAFRTFYLDGLFTDITLQCASGQI---FHCHKAALAACSSYFKVMFTADMKEKSNNVIKLS------GIDHD 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 959074889 135 TVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCV 188
Cdd:cd18252   73 ILEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-187 1.63e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 64.83  E-value: 1.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  52 FGCPAHCSDLAWRQNEQRRHGLYCDITLAFGGAGMAreYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGgp 131
Cdd:cd18239    1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDET--FPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIG-- 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 959074889 132 dsdtVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNC 187
Cdd:cd18239   77 ----LKNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 182-279 2.31e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 63.71  E-value: 2.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....*...
gi 959074889 262 ERERYFEDLFKLLRLSQM 279
Cdd:cd18477   81 NRQKALPTVFESIRFRLL 98
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 183-237 3.80e-12

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 61.52  E-value: 3.80e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 959074889 183 NLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSD 237
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 182-276 4.59e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 62.66  E-value: 4.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*
gi 959074889 262 ERERYFEDLFKLLRL 276
Cdd:cd18467   81 ERQKYLAQLLHCVRL 95
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 182-276 5.63e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 62.38  E-value: 5.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                         90
                 ....*....|....*
gi 959074889 262 ERERYFEDLFKLLRL 276
Cdd:cd18479   81 SRSQYLSSVLSQIRI 95
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-179 7.09e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 62.57  E-value: 7.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGgfaesrSGRVELQKWSSEGGPDSDTV 136
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVGG----TPLRAHKAVLIACSGFFYSIFSG------RVGEGVSVLTLPSGLEARGF 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 959074889 137 EAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLK 179
Cdd:cd18332   72 QLLLDFMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 72-190 8.50e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 63.05  E-value: 8.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  72 GLYCDITLAFggagMAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGgpdsdtVEAVIGFMYTGTIRVS 151
Cdd:cd18244   28 GLLLDVTLVI----EDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATG------FSHVLQFMYYGTIELS 97

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 959074889 152 PGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18244   98 MLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEI 136
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-185 1.09e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 62.39  E-value: 1.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRV-ELQKWSSEGgpds 133
Cdd:cd18230    2 TSHYRHLLRELNEQRQHGILCDVCIIVEG----KIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVtHLDIVTAQG---- 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 959074889 134 dtVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLS 185
Cdd:cd18230   74 --FKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 182-276 1.10e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 61.41  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFytlpFHLVRDW----LSDSEITVDSEEILFETVLKWVQ 257
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEF----LHLTKDQlisiLNSDDLNVEKEEHVYESIIHWFE 76

                         90       100
                 ....*....|....*....|
gi 959074889 258 KNPEERERYFEDLF-KLLRL 276
Cdd:cd18483   77 HEQSKREMHLPEIFaKCIRM 96
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 70-189 1.44e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 61.75  E-value: 1.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  70 RHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEggpdsdTVEAVIGFMYTGTIR 149
Cdd:cd18263    9 EKGVGCDVQLEADGS----IFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAK------DLRLLISFAYSGILH 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 959074889 150 VSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVA 189
Cdd:cd18263   79 LSWENLFEATCTALQLQISGALALCLDFLQREISPARCLD 118
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 71-186 1.49e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 61.61  E-value: 1.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  71 HGLYCDITLAfggAGMAREYRAHRSVLAAATEYFTPLLSGGFAE-SRSGRVELQkwssegGPdSDTVEAVIGFMYTGTIR 149
Cdd:cd18302    2 HSDLYDVTIV---SEDGKEFPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTMP------IP-SDILEIILDYLYTDEAS 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 959074889 150 VSPGN-----VHEVLEMADRFLLTRLKDFCGEFLKKKLNLSN 186
Cdd:cd18302   72 AVKESqnvefLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 185-260 1.53e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 60.60  E-value: 1.53e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 959074889 185 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNP 260
Cdd:cd18474    4 NNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-177 1.70e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 61.31  E-value: 1.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGfaesRSGRVELQKWSSEggpdsdTVEAVIGFMYT 145
Cdd:cd18232   10 NKQREEGQYCDATLDVGG----RVFKAHWSVLACCSHFFQSLYGDG----TSGSVVLPESFAE------VFGLLLDFFYT 75

                         90       100       110
                 ....*....|....*....|....*....|..
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEF 177
Cdd:cd18232   76 GELALTRENRDRVLLAAKELRVPEAVELCQRF 107
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
341-457 1.94e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 65.18  E-value: 1.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 341 DVIMVIGGVSEGGDYlsecvgyfideDRWVNLPHIHNHLDGHAVAVTESYVYVAGSmEPGFAKTVERYNPNRNIWEQVSN 420
Cdd:COG3055  170 GKILVIGGRNGSGFS-----------NTWTTLAPLPTARAGHAAAVLGGKILVFGG-ESGFSDEVEAYDPATNTWTALGE 237

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 959074889 421 LITRKHSFGLTEVKGNLYSIGGH---GNFSPGFKDVAIYN 457
Cdd:COG3055  238 LPTPRHGHAAVLTDGKVYVIGGEtkpGVRTPLVTSAEVYD 277
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-188 2.07e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 61.94  E-value: 2.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  73 LYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKwsseggPDSDTVEAVIGFMYTGTIRVSP 152
Cdd:cd18270   25 LLTDIVLIVEGT----EFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRN------VDAATLQIIITYAYTGNLAIND 94

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 959074889 153 GNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCV 188
Cdd:cd18270   95 STVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-163 2.67e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 60.92  E-value: 2.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFtpllsGGFAESRSGRVEL---QKWSSEGgpds 133
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQF----QFKAHRNVLAAFSEYF-----GAQYKDTEDNIVFldqSQVSADG---- 67

                         90       100       110
                 ....*....|....*....|....*....|
gi 959074889 134 dtVEAVIGFMYTGTIRVSPGNVHEVLEMAD 163
Cdd:cd18217   68 --FQKLLEFIYTGNLNLDSWNVAEIHQAAS 95
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-186 3.26e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 61.01  E-value: 3.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  73 LYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWsseggpDSDTVEAVIGFMYTGTIRVSP 152
Cdd:cd18279   17 RFTDCCLCVGG----QEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDV------DPEVFKEMMRFIYTGKAPNLD 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 959074889 153 GNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSN 186
Cdd:cd18279   87 KMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 181-284 3.73e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 60.46  E-value: 3.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 181 KLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNP 260
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|....
gi 959074889 261 EERERYFEDLFKLLRLSQMKPTYL 284
Cdd:cd18511   81 EQRRKDLSKLLAYIRLPLLAPQFL 104
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 70-190 4.12e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 60.83  E-value: 4.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  70 RHGLYCDITLAFGGAGMAreyrAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTIR 149
Cdd:cd18336   15 QHKQLCDVLLIAGNLKIP----AHRLVLSAVSDYFAAMFTNDVREAKQEEIKME------GVDPDALKALVHYAYTGVLE 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 959074889 150 VSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18336   85 LKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 88-186 5.26e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 60.37  E-value: 5.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  88 REYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQ--KWsseggpdsDTVEAVIGFMYTG---TIRVSPGNVHEVLEMA 162
Cdd:cd18297   22 RPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPdiRY--------DIFQLMMQYLYTGgveSLDVAQDDALELLRAA 93

                         90       100
                 ....*....|....*....|....
gi 959074889 163 DRFLLTRLKDFCGEFLKKKLNLSN 186
Cdd:cd18297   94 SFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-166 5.43e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 60.19  E-value: 5.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  67 EQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLlsggFAEsrSGRVELQKWSSEGGPdSDTVEAVIGFMYTG 146
Cdd:cd18212   16 EQRKKDFLCDITLIVENV----QFRAHKALLAASSEYFSMM----FAD--EGEVGQSIYMLEGMV-AETFGALLEFIYTG 84

                         90       100
                 ....*....|....*....|
gi 959074889 147 TIRVSPGNVHEVLEMAdRFL 166
Cdd:cd18212   85 CLQVGEKSLEQILATA-QFL 103
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-178 8.67e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 59.57  E-value: 8.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  73 LYCDITLAFGGAGmaREYRAHRSVLAAATEYFTPLLSGGFA-ESRSGRVELQKwsseggPDSDTVEAVIGFMYTGTIRVS 151
Cdd:cd18294   13 EFSDVKFLVGPER--QEIFAHKCILAARCEVFRAMFLTGPQkESTQSPLVLSD------IEPEVFRAVLEFIYTNCVTLS 84

                         90       100
                 ....*....|....*....|....*..
gi 959074889 152 PGNVHEVLEMADRFLLTRLKDFCGEFL 178
Cdd:cd18294   85 NHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-167 1.14e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 59.67  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLlsggFAESRSGRVELqkwssEGGPDSDTVEAVIGFMYT 145
Cdd:cd18290   19 NEQRLQGLYCDVSVVVKG----HAFKAHRAVLAASSSYFRDL----FNSSRSAVVEL-----PAAVQPQSFQQILSFCYT 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 959074889 146 GTIRVSPGN------------VHEVLEMADRFLL 167
Cdd:cd18290   86 GRLSMNVGDqfllmytagflqIQEIMEKGTEFFL 119
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-183 1.20e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 59.58  E-value: 1.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  56 AHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGR-------VELQKWSse 128
Cdd:cd18201    3 SYCYQLLQELNEQRKKGILCDVNIVVSG----KVFRAHKNILVAGSRFFKTLYCFTNKESCDQTtvthldvVAVQGFS-- 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 959074889 129 ggpdsdtveAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLN 183
Cdd:cd18201   77 ---------VILDFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 88-190 1.22e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 59.62  E-value: 1.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  88 REYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLL 167
Cdd:cd18274   33 KTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIV------GVEAESMHLVLDYAYTSRVTLTEANVQALFTAASIFQI 106

                         90       100
                 ....*....|....*....|...
gi 959074889 168 TRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18274  107 PSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-178 1.24e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 59.07  E-value: 1.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  56 AHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAE-SRSGRVELQKWSSeggpdsD 134
Cdd:cd18329    3 SHQSRLLQQLDEQRKQELFCDCSILVEG----QVFKAHRNVLFASSGYFKMLLSQNAKEtGQPTVATFDVFSP------D 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 959074889 135 TVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFL 178
Cdd:cd18329   73 TFTIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 90-182 1.51e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 59.23  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  90 YRAHRSVLAAATEYFTPLLSGGFAESRSGR-----VELQKWSSEggpdsdTVEAVIGFMYTGTIRVSPGNVHEVLEMADR 164
Cdd:cd18296   29 FPCHKAFFCGRSDYFKALLRDHFAESEENNgsipvVTLHDVSPE------VFAIVLYYIYTDDTDLPPENAYDVLYVADM 102

                         90
                 ....*....|....*...
gi 959074889 165 FLLTRLKDFCGEFLKKKL 182
Cdd:cd18296  103 YLLPGLKRLCGTVLAQSL 120
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-182 1.85e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 59.10  E-value: 1.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGR-------VELQKWSSEG 129
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQD----KIFRAHKVVLAACSDFFRSKLVGQASPRLVLVspagkcvLDLHHVTVTG 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 959074889 130 gpdsdtVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKL 182
Cdd:cd18228   78 ------FAPLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 180-283 1.95e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 58.23  E-value: 1.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 180 KKLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKN 259
Cdd:cd18469    1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                         90       100
                 ....*....|....*....|....
gi 959074889 260 PEERERYFEDLFKLLRLSQMKPTY 283
Cdd:cd18469   81 PQARAAHLPELLSLVHLSLLTDQY 104
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 181-276 2.84e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 57.82  E-value: 2.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 181 KLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNP 260
Cdd:cd18459    1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                         90
                 ....*....|....*.
gi 959074889 261 EERERYFEDLFKLLRL 276
Cdd:cd18459   81 QERRPHLPQVLQHVRL 96
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 76-197 3.75e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 58.04  E-value: 3.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  76 DITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEggpdsdTVEAVIGFMYTGTIrVSPGNV 155
Cdd:cd18286   19 DITIKVDG----KTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHA------AVSFVLLFIYGGVL-DLPDDV 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 959074889 156 H--EVLEMADRFLLTRLKDfcgeflkkklnlsncVAVHSLAHMY 197
Cdd:cd18286   88 NlgELLSLADMYGLDGLKD---------------VVAYTLRRDY 116
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-177 3.75e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 57.63  E-value: 3.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLlsggFAESRSgRVELQKWSSEGgpdsd 134
Cdd:cd18206    3 PQHSQHVLEQLNQQRQLGLLCDCTFVVDGV----DFKAHKAVLAACSEYFRML----FVDQKD-VVHLDISNAAG----- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 959074889 135 tVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEF 177
Cdd:cd18206   69 -LGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-190 4.48e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 57.93  E-value: 4.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  74 YCDITLAFGgagmAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKwsseggPDSDTVEAVIGFMYTGTIRVSPG 153
Cdd:cd18341   27 FVDCTLKAG----DKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDN------VDPNIMDMILKYLYSAEIDLNDG 96

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 959074889 154 NVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18341   97 NVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-178 4.82e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 57.43  E-value: 4.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAES-RSGRVELQKWSSeggpdsDT 135
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSIIVEG----RIFKAHRNVLFASSGYFRMLLSHYIQDTgRPSTASFDVFSS------DA 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 959074889 136 VEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFL 178
Cdd:cd18199   71 FSIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-177 5.68e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 56.74  E-value: 5.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  74 YCDITLAFGgagmAREYRAHRSVLAAATEYFTPLLSGGF---AESRSGRVELQKWSSEggpdsdTVEAVIGFMYTGTIRV 150
Cdd:cd18307    1 FCDVVISVD----NHSFAAHRNVLAAVSPFVKSLISSNDmkaTDELSITIDCDYLSPE------TVEQLLDYFYTGKIVI 70

                         90       100
                 ....*....|....*....|....*..
gi 959074889 151 SPGNVHEVLEMADRFLLTRLKDFCGEF 177
Cdd:cd18307   71 SEKNVEDLLKGAKYFNIPRLKDHCVDF 97
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 181-284 5.95e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 56.85  E-value: 5.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 181 KLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNP 260
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90       100
                 ....*....|....*....|....
gi 959074889 261 EERERYFEDLFKLLRLSQMKPTYL 284
Cdd:cd18510   81 QNRQKDLGMLLSYIRLPLLPPQLL 104
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-109 6.15e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 57.60  E-value: 6.15e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLS 109
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDT----KFRAHRSVLAASSPYFRELLS 49
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 72-190 6.23e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 57.98  E-value: 6.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  72 GLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEggpdsdTVEAVIGFMYTGTIRVS 151
Cdd:cd18272   30 GLFADVTISVEG----KEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSES------VFQLLVDYIYHGTVKLR 99

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 959074889 152 PGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18272  100 VEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-186 8.03e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 56.94  E-value: 8.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  67 EQRRhglYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKwsseggPDSDTVEAVIGFMYTG 146
Cdd:cd18343   17 ENSR---FTDCSLFVGG----QEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEIND------VDPEVFKEMMRFIYTG 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 959074889 147 TIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSN 186
Cdd:cd18343   84 KAPNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-177 1.02e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 56.42  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGgfaesrSGRVELQKWSSEGGPDSDTV 136
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGR----EQFRAHKTVLMACSGLFYSIFTD------QLKNNVSVINLDPEIEPEGF 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 959074889 137 EAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEF 177
Cdd:cd18215   72 RILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 182-277 1.48e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 55.62  E-value: 1.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18514    1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                         90
                 ....*....|....*.
gi 959074889 262 ERERYFEDLFKLLRLS 277
Cdd:cd18514   81 KRKDYLPELLRNVRLA 96
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 182-276 3.14e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 54.50  E-value: 3.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNpE 261
Cdd:cd18470    1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-Q 79

                         90
                 ....*....|....*
gi 959074889 262 ERERYFEDLFKLLRL 276
Cdd:cd18470   80 KRVKYAADLLSNIRF 94
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 182-276 3.16e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 54.62  E-value: 3.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90
                 ....*....|....*
gi 959074889 262 ERERYFEDLFKLLRL 276
Cdd:cd18456   81 GRRQHVPRLMKCVRL 95
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-188 3.18e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 55.61  E-value: 3.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  93 HRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGgpdsdtVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKD 172
Cdd:cd18271   39 HRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKA------VKAFLDYAYTGKAEITDDNVEMFFQMSSFLQVSLLSK 112

                         90
                 ....*....|....*.
gi 959074889 173 FCGEFLKKKLNLSNCV 188
Cdd:cd18271  113 ACSDFLIKSIDLTNCL 128
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 92-182 3.34e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 54.94  E-value: 3.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  92 AHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTIRVSP-GNVHEVLEMADRFLLTRL 170
Cdd:cd18300   23 AHKALLVARCDVMAAMFGGNFRESSAKEVELP------GVSKETFLALLEYLYTDQAPILEdGDCVGLIVLANRLCLPRL 96

                         90
                 ....*....|..
gi 959074889 171 KDFCGEFLKKKL 182
Cdd:cd18300   97 VALCEQYIVKEL 108
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 62-163 3.75e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 54.52  E-value: 3.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  62 AWRQNEQRrhgLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGgfaeSRSGRVELqkwssegGPDSDTV--EAV 139
Cdd:cd18262    9 AQRLREQR---LLLDETVSVGG----RSYGVHSVILAAVSSLFRERLLG----SNGPLPPL-------SLEVTPVgwEAV 70

                         90       100
                 ....*....|....*....|....
gi 959074889 140 IGFMYTGTIRVSPGNVHEVLEMAD 163
Cdd:cd18262   71 LTFAYTGVLGRNPATVGDILVAAE 94
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 182-259 4.22e-09

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 53.51  E-value: 4.22e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKN 259
Cdd:cd18503    1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEHN 78
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 70-190 5.61e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 55.07  E-value: 5.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  70 RHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTIR 149
Cdd:cd18337   19 RHKQLCDVVLVAGD----RRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKME------GVEPNALWALVQYAYTGRLE 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 959074889 150 VSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18337   89 LKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-174 5.85e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 54.30  E-value: 5.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGAGMareyRAHRSVLAAATEYFTPLLSGGFAEsrsgrVELQKWSSeggpdSDTVEAVIGFMYT 145
Cdd:cd18208   17 NEQRNRGHFCDVTVRIHGSML----RAHRCVLAAGSPFFQDKLLLGYSD-----IEIPSVVS-----VQSVQKLIDFMYS 82

                         90       100
                 ....*....|....*....|....*....
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFC 174
Cdd:cd18208   83 GVLRVSQSEALQILTAASILQIKTVIDEC 111
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
343-490 5.96e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 57.86  E-value: 5.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 343 IMVIGGVSEGGDYLSECVgYFIDEDRWV---NLPHIHNHLdgHAVAVTESYVYVAGsmepGFAKTVerynpNRNIWEQVS 419
Cdd:COG3055  124 IYVVGGWDDGGNVAWVEV-YDPATGTWTqlaPLPTPRDHL--AAAVLPDGKILVIG----GRNGSG-----FSNTWTTLA 191

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 959074889 420 NLITRKHSFGLTEVKGNLYSIGGHGNFspgFKDVAIYNPEQDKWVNLESAPKILRDVKAVSVEDRfVYVAA 490
Cdd:COG3055  192 PLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGK-VYVIG 258
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 182-256 6.01e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 53.16  E-value: 6.01e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWV 256
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 75-190 8.64e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 54.28  E-value: 8.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  75 CDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTIRVSPGN 154
Cdd:cd18335   20 CDVILIAGN----RKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKME------GIDPNALWDLVQFAYTGCLELKEDT 89

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 959074889 155 VHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18335   90 IENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-180 8.85e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 54.20  E-value: 8.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHG-LYCDITLAFGgagmAREYRAHRSVLAAATEYFTPLLSGGFAESRSGR-VELQKWSSEGGPDsd 134
Cdd:cd18207    9 HSADMLHNLNQQRKSGgRFCDVLLRVG----EESFPAHRAVLAACSEYFESVFSAQEGDGGTPReLEMHTISSKVFGD-- 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 959074889 135 tveaVIGFMYTGTIRVSPGNVHEVLEMAdRFLLTR-LKDFCGEFLKK 180
Cdd:cd18207   83 ----ILDFAYTSRIVVRLESFPELMTAA-KFLLMRsVIDICQEVIKQ 124
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 76-186 9.02e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 54.02  E-value: 9.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  76 DITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEggpdsdTVEAVIGFMYTGTIRVSPGNV 155
Cdd:cd18352   15 DVTFLVEG----RRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWE------VFELMMRFIYTGSVDITNDIA 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 959074889 156 HEVLEMADRFLLTRLKDFCGEFLKKKLNLSN 186
Cdd:cd18352   85 KDLLRAADQYLLEGLKRLCEYTIAQDLTLEN 115
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 185-281 1.03e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 53.19  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 185 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPEERE 264
Cdd:cd18485    4 SNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSRV 83

                         90
                 ....*....|....*..
gi 959074889 265 RYFEDLFKLLRLSQMKP 281
Cdd:cd18485   84 QHLVELLKQVRLELVSP 100
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-188 1.26e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 53.48  E-value: 1.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  73 LYCDITLAFGGagmaREYRAHRSVLAAATEYFTPllsggfaESRSGRVELQkWSsegGPDSDTVEAVIGFMYTGTIRVSP 152
Cdd:cd18303   17 LYSDITIKLAD----KSIPAHKFVLAARSEKWSN-------ENLASTNELD-LS---DISYEVVLALLRWLYTDELDLTL 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 959074889 153 GNVH--EVLEMADRFLLTRLKDFCGEFLKKKLNLSNCV 188
Cdd:cd18303   82 DDEFllELMKAAKRFQLTDLVERCERALMSSVNVDNCI 119
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 182-284 1.33e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 53.10  E-value: 1.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90       100
                 ....*....|....*....|...
gi 959074889 262 ERERYFEDLFKLLRLSQMKPTYL 284
Cdd:cd18509   82 RRCSDLSMLLAYIRLPLLPPQLL 104
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-181 1.35e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 53.51  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGgagmAREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELqkwsseggpDSD 134
Cdd:cd18196    2 PGHFEQIFQQLNYQRLHGQLCDCVIVVG----NRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQL---------DSE 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 959074889 135 TV-----EAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKK 181
Cdd:cd18196   69 VVtaeafAALIDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTR 120
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 76-165 1.45e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 52.13  E-value: 1.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  76 DITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELqkwsSEGGPDSDTVEAVIGFMYTGT-IRVSPGN 154
Cdd:cd18190    1 DLVFCVGG----EKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDF----EENGISIEAMRAVIDFSVTGRlDLFSVEN 72

                         90
                 ....*....|.
gi 959074889 155 VHEVLEMADRF 165
Cdd:cd18190   73 VHEVLELASKF 83
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-186 1.62e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 53.31  E-value: 1.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  74 YCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKwsseggPDSDTVEAVIGFMYTGTIRVSPG 153
Cdd:cd18345   18 FSDVTLCVGG----REFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITD------VDHEVMREMLRFIYTGKAPNLDK 87

                         90       100       110
                 ....*....|....*....|....*....|...
gi 959074889 154 NVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSN 186
Cdd:cd18345   88 MADDLLAAADKYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-178 1.64e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 53.15  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGgfaeSRSGRVELQKwsseggPDSDTV 136
Cdd:cd18277   10 HSTNVLLSLNDQRKKDVLCDVTILVEG----QRFRAHRSVLAACSSYFHSRIVG----QADAELNITL------PEEVTV 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 959074889 137 ---EAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFL 178
Cdd:cd18277   76 kgfEPLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-178 1.77e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 53.01  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESrsGRvelqkwSSEGGPDSDTVEA---VIGF 142
Cdd:cd18330   10 NEQRKRDFFCDCSIIVEG----RIFKAHRNILFANSGYFRALLIHYIQDS--GR------HSTASLDIVTSEAfsiILDF 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 959074889 143 MYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFL 178
Cdd:cd18330   78 LYSGKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 74-165 1.84e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 51.78  E-value: 1.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  74 YCDITLAFGGagmaREYRAHRSVLAAATEYFTPLlsggfaesrsgrveLQKWSSEGGP-------DSDTVEAVIGFMYTG 146
Cdd:cd18315    1 LVDVTLACEG----GSLKAHKLVLAAASPYFAAL--------------LKETPPDEHPviilpdvPYSELKALLDFIYTG 62

                         90
                 ....*....|....*....
gi 959074889 147 TIRVSPGNVHEVLEMADRF 165
Cdd:cd18315   63 EVNVSQEQLESLLKLAELL 81
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-188 2.30e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 52.89  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSggfAESRSGRVELQKWSSEGgpdsdtVEAVIGFMYT 145
Cdd:cd18260   10 NRMRQERFLCDLTIATKT----KSFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLG------LATVITYAYT 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCV 188
Cdd:cd18260   77 GKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 185-277 2.68e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 51.90  E-value: 2.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 185 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPEERE 264
Cdd:cd18515    3 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRH 82

                         90
                 ....*....|...
gi 959074889 265 RYFEDLFKLLRLS 277
Cdd:cd18515   83 CYLSELLQTVRLA 95
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-180 2.72e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 52.55  E-value: 2.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGAGMareyRAHRSVLAAATEYFTPLLSGGFAESRSGRVelqkwsseggPDSDTVEAVIGFMYT 145
Cdd:cd18229   10 NAQRLGGHFCDVTVRIHDASL----RAHRCVLAAGSPFFHDKLLLGHSEIEVPPV----------VPAQTVRQLVEFMYS 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKK 180
Cdd:cd18229   76 GSLVVAQSEALQILTAASILQIKTVIDECTQIISQ 110
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 194-256 2.99e-08

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 51.04  E-value: 2.99e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 959074889 194 AHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWV 256
Cdd:cd18493   12 AKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-174 5.23e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 51.78  E-value: 5.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPL-LSGGFAESRSGRVELQKWSSEggpdsdT 135
Cdd:cd18202    2 HGQTVLDQLNQQRLNNQFCDVTLLIEG----EEYKAHKSVLAANSEYFRELfIEKGAVSSHEAVVDLSGFCKS------S 71

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 959074889 136 VEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFC 174
Cdd:cd18202   72 FLPLLEFAYTSELTFDFCSMAEVAMLARHLFMNEVLEIC 110
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-161 5.70e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 51.41  E-value: 5.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGrVELQKWsseggpDSDTV 136
Cdd:cd18209    1 HAISLLSALNEERLKGQLCDVLLIVGD----QKFRAHKNVLAASSEYFQSLFTEKENESQSV-FQLDFC------EPDAF 69

                         90       100
                 ....*....|....*....|....*
gi 959074889 137 EAVIGFMYTGTIRVSPGNVHEVLEM 161
Cdd:cd18209   70 ENVLNYIYSSSLFVEKSSLAAVQEL 94
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 185-277 6.26e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 50.96  E-value: 6.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 185 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPEERE 264
Cdd:cd18464    3 SNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRH 82

                         90
                 ....*....|...
gi 959074889 265 RYFEDLFKLLRLS 277
Cdd:cd18464   83 EVLPELLRSVRLA 95
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 182-276 6.66e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 50.89  E-value: 6.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18462    1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                         90
                 ....*....|....*
gi 959074889 262 ERERYFEDLFKLLRL 276
Cdd:cd18462   81 KRIECAYDLLSSIKL 95
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-186 6.79e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 51.98  E-value: 6.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  82 GGAGMAREYRAHRSVLAAATEYFTPLLSGGFAESrSGRVELqkwsseggPDSDTVE--AVIGFMYTGTIRVSPGNVHEVL 159
Cdd:cd18346   36 GPGPGAQRIPAHRFVLAAGSAVFDAMFNGGMATT-SAEIEL--------PDVEPAAflALLRFLYSDEVQIGPETVMTTL 106

                         90       100
                 ....*....|....*....|....*..
gi 959074889 160 EMADRFLLTRLKDFCGEFLKKKLNLSN 186
Cdd:cd18346  107 YTAKKYAVPALEAHCVEFLTKHLRADN 133
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 181-276 8.03e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 50.82  E-value: 8.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 181 KLNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNP 260
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                         90
                 ....*....|....*.
gi 959074889 261 EERERYFEDLFKLLRL 276
Cdd:cd18447   81 PNRQPYMVDILAKVRF 96
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 72-177 9.80e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 50.75  E-value: 9.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  72 GLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLS-GGFAESRSGRVELQkwssEGGPDSDTVEAVIGFMYTGTIRV 150
Cdd:cd18292   15 EELSDIVLRVGG----KVFHAHRLILAKSSDVFRVMLSnDWWSESKQSEIELV----EDPECAAVFEKFLRYLYTGQISV 86

                         90       100
                 ....*....|....*....|....*..
gi 959074889 151 SPGNVHEVLEMADRFLLTRLKDFCGEF 177
Cdd:cd18292   87 NLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-179 9.87e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 50.66  E-value: 9.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGAGmareYRAHRSVLAAATEYFTPLLSGGFAESRS-GRVELQKWSSEGgpdsdt 135
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVC----FKAHKNVLAAFSQYFRSLFQNSSSQKNDvFHLDIKNVGGIG------ 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 959074889 136 veAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLK 179
Cdd:cd18233   71 --QILDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 75-186 1.17e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 50.84  E-value: 1.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  75 CDITLAFGGAGMAREYRAHRSVLAAATEYFTPLLSGGFAESrSGRVELqkwsseggPDSDTVE--AVIGFMYTGTIRVSP 152
Cdd:cd18347   23 SDVHFLVGKGLGSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIEL--------PDVEPAAflALLKFLYSDEVQIGP 93

                         90       100       110
                 ....*....|....*....|....*....|....
gi 959074889 153 GNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSN 186
Cdd:cd18347   94 ETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 75-178 1.56e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 49.77  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  75 CDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSgrVELqkwsseggPDSDTVEA---VIGFMYTGTIRVS 151
Cdd:cd18955    2 CDVTIVVED----QRFRAHRAVLAACSDYFLSRVVGQTDGDLV--ITL--------PEEVTVKGfepLLQFAYTAKLLLS 67

                         90       100
                 ....*....|....*....|....*..
gi 959074889 152 PGNVHEVLEMADRFLLTRLKDFCGEFL 178
Cdd:cd18955   68 KENVLEVCRCAEFLGVHNIEKACFDFL 94
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-178 2.12e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 49.84  E-value: 2.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFtpllsggfaesrSGRVELQKWSSEGGP--- 131
Cdd:cd18210    2 PEITSSLLESLNQQRMEGKLCDISIHVQG----RVFRAHRAVLAASSPYF------------HDQVLLKNMSSISLPgvm 65

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 959074889 132 DSDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFL 178
Cdd:cd18210   66 DPGAFESVLASAYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-151 2.46e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 50.03  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGgfaESRSGrVELqkwsseggPDSDT---VEAVIGF 142
Cdd:cd18289   21 NEQRLMGLYCDVSIVVKG----QAFKAHRAVLAASSLYFRDLFSG---NSKSA-FEL--------PATVPpacFQQILSF 84


                 ....*....
gi 959074889 143 MYTGTIRVS 151
Cdd:cd18289   85 CYTGKLTMA 93
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 74-170 4.00e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 49.12  E-value: 4.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  74 YCDITLAFGGAgmaREYRAHRSVLAAATEYFTPLlsGGFAESRSGRVELqkwssEGGPDSDTVEAVIGFMYTGTIRVSPG 153
Cdd:cd18311   14 YCDLTLQFRDN---EQLKVHRLVLSACTDYFNVL--EQTCEIVDDTLIM-----PNELQADAVVPVINFMYTGQLEFEEK 83

                         90
                 ....*....|....*..
gi 959074889 154 NVHEVLEMADRFLLTRL 170
Cdd:cd18311   84 SYGKLLRTAKELNMTVL 100
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-186 4.42e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 49.33  E-value: 4.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  87 AREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKwsseggPDSDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFL 166
Cdd:cd18342   31 GQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND------VEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYA 104

                         90       100
                 ....*....|....*....|
gi 959074889 167 LTRLKDFCGEFLKKKLNLSN 186
Cdd:cd18342  105 LERLKVMCEDALCSNLSVEN 124
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-186 5.49e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 49.27  E-value: 5.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSggfaesrSGRVELQKWSSEGgpdsd 134
Cdd:cd18243   13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQG----QQFHCHKAVLASCSQYFRSLFS-------INNLVLQGCSSIG----- 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 959074889 135 tVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSN 186
Cdd:cd18243   77 -LRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-109 5.55e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 48.29  E-value: 5.55e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 959074889  66 NEQRRHGLYCDITLAFggagMAREYRAHRSVLAAATEYFTPLLS 109
Cdd:cd18219   13 NEQRGHGLFCDVTVIV----EDRKFRAHKNILSASSTYFHQLFS 52
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 75-186 6.03e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 48.97  E-value: 6.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  75 CDITLAFGGAGMAREYRAHRSVLAAATEYFTPLLSGGFAeSRSGRVELqkwsseggPDSDTVE--AVIGFMYTGTIRVSP 152
Cdd:cd18281   23 SDVHFIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMA-TTSAEIEL--------PDVEPAAflALLRFLYSDEVQIGP 93

                         90       100       110
                 ....*....|....*....|....*....|....
gi 959074889 153 GNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSN 186
Cdd:cd18281   94 ETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 88-165 8.09e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 47.28  E-value: 8.09e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 959074889  88 REYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGgpdsdtVEAVIGFMYTGTIRVSPGNVHEVLEMADRF 165
Cdd:cd01165    8 EKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPED------FRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-181 1.33e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 48.50  E-value: 1.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  51 EFgcPAHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLSGGFaeSRSGRVELqkwssegg 130
Cdd:cd18324    2 EF--PDHSRHLLQCLSEQRHQGFLCDCTVLVGDA----QFRAHRAVLASCSMYFHLFYKDQL--DKRDIVHL-------- 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 959074889 131 pDSDTVEA-----VIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKK 181
Cdd:cd18324   66 -NSDIVTApafalLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK 120
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-182 2.63e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 47.12  E-value: 2.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  51 EFgcPAHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPllsggFAESRSGRVELQKWssegg 130
Cdd:cd18194    2 EF--PEHSRQLLQCLREQRSQGFLCDCTVLVGSA----QFPAHRAVLASCSMYFHL-----FYRDRLDKRDLVRL----- 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 959074889 131 pDSDTVEA-----VIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKL 182
Cdd:cd18194   66 -NSDIVTApafglLLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKA 121
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-176 2.74e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 46.57  E-value: 2.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLSGGFAESrSGRVELQKWSseggpdSDTVEAVIGFMYT 145
Cdd:cd18204   10 NEQRLEGEFCDIAIVVEDV----KFRAHRCVLAACSTYFKKLFKKLEVDS-SSVIEIDFLR------SDIFEEVLNYMYT 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGE 176
Cdd:cd18204   79 AKISVKKEDVNLMMSSGQILGIRFLDKLCSQ 109
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-180 3.41e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 46.50  E-value: 3.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLsggfaeSRSGRVELqkwsseggpDSD 134
Cdd:cd18334    2 PNHAKQLLLQLNQQRAKGFLCDVIIVVENA----LFRAHKNILAASSMYFKSLV------LHDNLINL---------DTD 62

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 959074889 135 TV-----EAVIGFMYTGTIRVS--PG--NVHEVLEMADRFLLTRLKDFCGEFLKK 180
Cdd:cd18334   63 MVnptvfRQILDFIYTGKLLTSdqPGeqNFNALLTAASYLQLHDLAALCRKKLKR 117
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 75-174 4.02e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 46.55  E-value: 4.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  75 CDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTIrvsPgN 154
Cdd:cd18280   15 ADVTFNVDG----EKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIE------DVEPPVFKALLHFIYKDEL---P-D 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 959074889 155 VHE----------------VLEMADRFLLTRLKDFC 174
Cdd:cd18280   81 DVEpagsdsssldttmaqhLLAAADRYALERLRLLC 116
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-179 5.08e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 46.09  E-value: 5.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  51 EFgcPAHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTP--LLSGgfaesrSGRVELqkwsse 128
Cdd:cd18227    4 EF--PDFSSTILQKLNQQRQQGQLCDISVVVQG----HLFRAHKAVLAASSPYFCDqvLLKN------SRRIVL------ 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 959074889 129 ggPD---SDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLK 179
Cdd:cd18227   66 --PDvmnPRVFENILLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-182 5.84e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 46.00  E-value: 5.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  69 RRHGLYCDITLAFGGAGMAREYRAHRSVLAAATEYFTPL-LSGGFAESRSGRVELQKWSSEggpdsdTVEAVIGFMYTGT 147
Cdd:cd18211   20 RLLGHLCDVTVQVEHQGSKEEFSAHKAVLAASSKYFKEVfLNEKISDGKNTNVMLNEIYTA------DFASFLEFVYTAK 93

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 959074889 148 IRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKL 182
Cdd:cd18211   94 VEVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-186 5.88e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 46.10  E-value: 5.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  73 LYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWsseggpDSDTVEAVIGFMYTGTIRV-- 150
Cdd:cd18344   22 LFTDCCLLVAG----HEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDL------DPQVFKEMMGFIYTGKAPHlh 91

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 959074889 151 SPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSN 186
Cdd:cd18344   92 SHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-174 9.18e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 45.59  E-value: 9.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPL-LSGGFAESRSGRVELQKWSSeggpdsdt 135
Cdd:cd18224    9 HPNNLLKELNKCRLSETMCDVTIVVGN----RSFAAHKAVLACAAGYFQKLfLSTELDVARTYVVDFITPAN-------- 76

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 959074889 136 VEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFC 174
Cdd:cd18224   77 FEKVLSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-183 9.58e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 45.22  E-value: 9.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLsggfaeSRSGRVELqkwsSEGGPDSD 134
Cdd:cd18216    1 PSHATQLLLQLNNQRTKGFLCDVIIVVENS----LFRAHKNVLAASSGYFKSLV------LHDNLIHL----DQDMVSPT 66

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 959074889 135 TVEAVIGFMYTGtiRVSPG-----NVHEVLEMADRFLLTRLKDFCgeflKKKLN 183
Cdd:cd18216   67 VFQQILDFIYTG--KLLDSlfeepNLSEVLAAANYLQLPDLAALC----RSKLK 114
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 182-270 9.67e-06

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 44.53  E-value: 9.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAhmYSLNQLALKAQ--DMIRRNFHKVIQDEEFYTLPfHLVRDWL--SDSEITVDSEEILFETVLKWVQ 257
Cdd:cd18502    1 LTPENCIGIRSFA--GRMNDSELLQKvdSYIQENIEEVAESKEFLKLP-RLQIEVIleSNQELESINERKLCQLVLEWVQ 77

                         90
                 ....*....|...
gi 959074889 258 KNPEERERYFEDL 270
Cdd:cd18502   78 RSIEEGGLDLDDL 90
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-181 1.00e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 45.41  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLSGGFaeSRSGRVELqkwsseggpDSD 134
Cdd:cd18325    4 PDHSRQLLQCLSQQRHQGFLCDCTVLVGEA----QFRAHRAVLASCSMYFHLFYRDQL--DKRDIVHL---------NSD 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 959074889 135 TVEA-----VIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKK 181
Cdd:cd18325   69 IVTApafslLLEFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKDK 120
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 64-178 1.09e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 44.91  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  64 RQNEQRrhgLY----CDITLAFGGagMAREYRAHRSVLAAATEYFTPLlsggFAESRS-GRVEL--QKWSSEGgpdsdtV 136
Cdd:cd18231    3 RLNEQR---LFqpdlCDVDIVLVR--QRSTFPAHKGVLAAYSQFFHSL----FTQNKQlQRVELslEALTSQG------L 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 959074889 137 EAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFL 178
Cdd:cd18231   68 QQILNFIYTSKLLVNSCNVQDVLNAAAVLQMNDIAASCQELI 109
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-172 1.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 44.78  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELqkwsseggPD--SDTVEAVIGFM 143
Cdd:cd18223   10 NEQRIQGILCDVTIVVEDT----KFKAHKNVLAASSLYFKNAFSSQEIWISSHVLEL--------PDlkAEVFAEILNFI 77

                         90       100       110
                 ....*....|....*....|....*....|
gi 959074889 144 YTGTIRV-SPGNVHEVLEMADRFLLTRLKD 172
Cdd:cd18223   78 YSSKVVVkRQETVTDLVAAGKKLGITFLEN 107
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-180 1.56e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 44.17  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  76 DITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSeggpdsDTVEAVIGFMYTGTIRVSPGNV 155
Cdd:cd18298   14 DLKFRVDG----KYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSY------PVYYAFLRYLYTDQVDLPPEDA 83

                         90       100
                 ....*....|....*....|....*
gi 959074889 156 HEVLEMADRFLLTRLKDFCGEFLKK 180
Cdd:cd18298   84 IGLLDLANSYCEERLKKLCEDIIKQ 108
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 182-260 1.82e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 43.95  E-value: 1.82e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNP 260
Cdd:cd18449    1 VSLENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHED 79
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-166 2.56e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 44.04  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLSGgfAESRSGRVELQ--KWSSEggpd 132
Cdd:cd18192    2 PSHSSYVLQQLNNQREWGFLCDCCIAIDDI----YFQAHKAVLAACSSYFRMMFIN--HQHTTAQLNLSnmKISAE---- 71

                         90       100       110
                 ....*....|....*....|....*....|....
gi 959074889 133 sdTVEAVIGFMYTGTIRVSPGNVHEvLEMADRFL 166
Cdd:cd18192   72 --CFDLILQFMYLGKIMTAPSDFEQ-LKVAMNYL 102
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 182-275 2.99e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 43.26  E-value: 2.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHK-VIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNP 260
Cdd:cd18482    1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                         90
                 ....*....|....*
gi 959074889 261 EERERYFEDLFKLLR 275
Cdd:cd18482   81 KERAASAAEVLKCVR 95
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-178 3.02e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 44.04  E-value: 3.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  69 RRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQkwssegGPDSDTVEAVIGFMYTGTI 148
Cdd:cd18251   18 RDSGILFDVVLVVEG----KPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIH------GVSYNAMCKILDFIYTSEL 87

                         90       100       110
                 ....*....|....*....|....*....|
gi 959074889 149 RVSPGNVHEVLEMADRFLLTRLKDFCGEFL 178
Cdd:cd18251   88 ELSLDNVQETLTAACQLQIPEVIGFCCDFL 117
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 182-279 3.21e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 43.35  E-value: 3.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQD--EEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKN 259
Cdd:cd18471    1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                         90       100
                 ....*....|....*....|
gi 959074889 260 PeeRERYFEDLFKLLRLSQM 279
Cdd:cd18471   81 C--RYQYMDELLQYVRFGLM 98
Kelch smart00612
Kelch domain;
593-639 3.71e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 3.71e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 959074889   593 VFIIGGWKNSddidkQYRKEAYRYCAERKRWMLLPPMPQPRCRATAC 639
Cdd:smart00612   2 IYVVGGFDGG-----QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-190 6.60e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 43.25  E-value: 6.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  93 HRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEggpdsdTVEAVIGFMYTGTIRVSPGNVHEV------LEMADRFL 166
Cdd:cd18276   36 HRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAE------SVSIILNYMYSSDLHLTNSNVQGVataaffLQMEDIFS 109

                         90       100
                 ....*....|....*....|....
gi 959074889 167 LtrlkdfCGEFLKKKLNLSNCVAV 190
Cdd:cd18276  110 V------CQKYMMDHMDASNCLGI 127
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-179 8.58e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 42.23  E-value: 8.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  59 SDLAWRQNEQRRH-GLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGgfaESRSgrvelqKWSSEGGPDSDTVE 137
Cdd:cd18218    2 SDRLLHLAARLRPaGALCDTLITVGS----QEFPAHSLVLAGASQQLGRQLTN---PNPG------QWCLGEGISPSTFK 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 959074889 138 AVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLK 179
Cdd:cd18218   69 QLLDFVYGESVEVQPGELRPLLEAARALEVESLEEACWRALG 110
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 186-265 8.76e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 42.05  E-value: 8.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 186 NCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWvQKNPEERER 265
Cdd:cd18461    5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY-HYTPEQVEK 83
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-179 1.14e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 42.27  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  76 DITLAFGGagmaREYRAHRSVLAAaTEYFTPLLSGGFAESRSGRVELQkwSSEGGPDSDTVEAVIGFMYTGTIRVSPGNV 155
Cdd:cd18305   17 DITICALG----REWKLHKIYLCQ-SGYFASMFSGSWKESKETVINLE--IPDDNITVEALNVVFGSLYRDEIEIKPSRV 89

                         90       100
                 ....*....|....*....|....
gi 959074889 156 HEVLEMADRFLLTRLKDFCGEFLK 179
Cdd:cd18305   90 VSILAAATLLQLDGLIQQCSEVMK 113
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-182 1.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 41.61  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  73 LYCDITLAFGGAGMAREYRAHRSVLAAATEYFTPLLSGGFAESRSgRVELqkwsseggPD--SDTVEAVIGFMYTGTIRV 150
Cdd:cd18282    6 LMADVHFIVGPPGGTQRIPAHKYVLATGSSVFYAMFYGGLAENKN-EIEI--------PDvePAAFLNLLRYLYCDEIDL 76

                         90       100       110
                 ....*....|....*....|....*....|..
gi 959074889 151 SPGNVHEVLEMADRFLLTRLKDFCGEFLKKKL 182
Cdd:cd18282   77 EPDTVLATLYAAKKYLVPHLARACVQFLETSL 108
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-104 1.51e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 41.76  E-value: 1.51e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 959074889  57 HCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYF 104
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHVQG----RVFRAHKAVLAASSPYF 44
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 92-127 1.75e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 41.34  E-value: 1.75e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 959074889  92 AHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSS 127
Cdd:cd18191   16 ASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPS 51
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 88-190 1.79e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 41.32  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  88 REYRAHRSVLAAATEYFTPLLSGGFAESRsgrvelqkwssegGPDSDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLL 167
Cdd:cd18275   14 QRIRAHKSVLAAKSDYFRARLSRDILKVK-------------GLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQM 80

                         90       100
                 ....*....|....*....|...
gi 959074889 168 TRLKDFCGEFLKKKLNLSNCVAV 190
Cdd:cd18275   81 PCAAQCAVDAVRAQLCLGNCYEV 103
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-179 1.81e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 41.55  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  51 EFGCPAHCSDLAWRQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFtpllsggfaESRSGRVELQKWSSEGG 130
Cdd:cd18220    2 QFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQG----QPFRAHKAVLAASSPYF---------RDHSALSTMSGLSISVI 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 959074889 131 PDSDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLK 179
Cdd:cd18220   69 KNPNVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILE 117
Kelch smart00612
Kelch domain;
391-435 2.84e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 2.84e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 959074889   391 VYVAGSMEPG-FAKTVERYNPNRNIWEQVSNLITRKHSFGLTEVKG 435
Cdd:smart00612   2 IYVVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 182-279 3.20e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 40.29  E-value: 3.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFH-----LVRDWLSDSEITVdseeilFETVLKWV 256
Cdd:cd14822    1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSalkelLSRDSFCAPEVDI------FNAVRRWC 74

                         90       100
                 ....*....|....*....|...
gi 959074889 257 QKNPEERERyFEDLFKLLRLSQM 279
Cdd:cd14822   75 EHNPDSKED-AKEILEAVRLPLM 96
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-182 3.77e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 40.35  E-value: 3.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  73 LYCDITLAFGGAGMAREYRAHRSVLAAATEYFTPLLSGGFAESRSgrvELQKwsseggPDSDTVEAVI--GFMYTGTIRV 150
Cdd:cd18349    7 LMADVHFIVGPPGASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKS---EIHI------PDVEPAAFLIllKYMYSDEIDL 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 959074889 151 SPGNVHEVLEMADRFLLTRLKDFCGEFLKKKL 182
Cdd:cd18349   78 EADTVLATLYAAKKYIVPALAKACVNFLETSL 109
BACK_KBTBD4 cd18481
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 186-270 4.27e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.


Pssm-ID: 350556  Cd Length: 88  Bit Score: 39.87  E-value: 4.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 186 NCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSeitVDSEEILFETVLKWVQKNPEEREr 265
Cdd:cd18481    5 NCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKDG---VPCSQNPTAAIEAWINHNKEERE- 80


                 ....*
gi 959074889 266 YFEDL 270
Cdd:cd18481   81 GFSET 85
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 381-421 4.29e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.36  E-value: 4.29e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 959074889  381 GHAVAVTESYVYVA-GSMEPGFAKTVERYNPNRNIWEQVSNL 421
Cdd:pfam01344   4 GAGVVVVGGKIYVIgGFDGNQSLNSVEVYDPETNTWSKLPSM 45
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-182 4.67e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 40.58  E-value: 4.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  51 EFgcPAHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFtpllsggfaesrsgrvelQKWSSEGG 130
Cdd:cd18323    2 EF--PDHSRHLLQSLREQRHQGFLCDCTVLVGST----QFLAHRAVLASCSPFF------------------HMFYKEQL 57

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 959074889 131 PDSDTV----EAV--------IGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCgeflKKKL 182
Cdd:cd18323   58 DKRDLVcinnEIVtapafsllLEFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVC----KKRL 117
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 185-284 5.61e-04

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 39.77  E-value: 5.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 185 SNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPEERE 264
Cdd:cd18466    4 ANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRK 83

                         90       100
                 ....*....|....*....|
gi 959074889 265 RYFEDLFKLLRLSQMKPTYL 284
Cdd:cd18466   84 KHVVEVLEPVRFPLLPPQRL 103
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-181 5.77e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 40.57  E-value: 5.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLSGGFAESRSGrVELqkwsseggpDSD 134
Cdd:cd18956    4 PEHGGRLLGRLRQQRELGFLCDCTVLVGDA----RFPAHRAVLAACSVYFHLFYRDRPAGGRDT-VRL---------NGD 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 959074889 135 TVEA-----VIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKK 181
Cdd:cd18956   70 IVTApafgrLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLREK 121
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-179 6.34e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 40.03  E-value: 6.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYFTPLLSGGfaesrsgrvELQKWSSEGGPDSDTVEAVIGFMYT 145
Cdd:cd18222   17 NQLRMQGRLCDIVVNVQG----QSFRAHKVVLAASSPYFRDHMSLN---------EMSTVSISVIKNPTVFEQLLSFCYT 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 959074889 146 GTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLK 179
Cdd:cd18222   84 GRICLQLADIISYLTAASFLQMQHIIDKCTQILE 117
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 64-104 1.02e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 39.21  E-value: 1.02e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 959074889  64 RQNEQRRHGLYCDITLAFGGagmaREYRAHRSVLAAATEYF 104
Cdd:cd18221    8 RLNEQRELDQFTDITLIVDG----HQFKAHKAVLAACSQFF 44
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 74-175 1.04e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 38.85  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  74 YC-DITLAFGGAgmarEYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKwsseGGPDSDTVEAVIGFMYTGTIRVSP 152
Cdd:cd18283    1 YCtDVDLVFQGT----CFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPT----AGIDVPMFSALLRYLYTGEFGSED 72

                         90       100
                 ....*....|....*....|...
gi 959074889 153 GNVhevlemADRFLLTRLKDFCG 175
Cdd:cd18283   73 SRS------QNLDVLIQLSEEFG 89
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-180 1.20e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 39.50  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  55 PAHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLLsggfaeSRSGRVELqkwsseggpDSD 134
Cdd:cd18333    2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNA----LFRAHKNILAASSVYLKSLV------VHDNLINL---------DHE 62

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 959074889 135 TVEA-----VIGFMYTGtiRVSPG------NVHEVLEMADRFLLTRLKDFCGEFLKK 180
Cdd:cd18333   63 MVSPgifrlILDYIYTG--RLSEGdpgseqNLGAVLAAASYLQIPDLVALCKKKLKR 117
PHA02790 PHA02790
Kelch-like protein; Provisional
 132-463 1.62e-03

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 41.57  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 132 DSDTVEAVIGFMYTGTIRVSPGNVHEVLEMADRFLLTRLKDFCGEFLKKKLNLSNCVAVHSLAHMYSLNQLALKAQDMIR 211
Cdd:PHA02790  70 DIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIA 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 212 RNFHKVIQD--EEFYTLPFHLVrdwLSDSEITVDSEEILFETVLKWVQKnpeeRERYFEDLFKLLRlSQMKPTYLT-RHV 288
Cdd:PHA02790 150 KHFLELEDDiiDNFDYLSMKLI---LESDELNVPDEDYVVDFVIKWYMK----RRNRLGNLLLLIK-NVIRSNYLSpRGI 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 289 KSERLVL-------CNEACVKLVSEAVESHALRSEnlQSGNLQHsACPAALLPrfgqnmDVIMVIGGVSEgGDYLSECVG 361
Cdd:PHA02790 222 NNVKWILdctkifhCDKQPRKSYKYPFIEYPMNMD--QIIDIFH-MCTSTHVG------EVVYLIGGWMN-NEIHNNAIA 291

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 362 YFIDEDRWVNLPHIHN-HLDGHAVAVTESYVYVAGSMEPgfaKTVERYNPNRNIWEQVSNLITRKHSFGLTEVKGNLYSI 440
Cdd:PHA02790 292 VNYISNNWIPIPPMNSpRLYASGVPANNKLYVVGGLPNP---TSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVI 368

                        330       340
                 ....*....|....*....|...
gi 959074889 441 GGHGNFSPGFKDVAiynPEQDKW 463
Cdd:PHA02790 369 GGHSETDTTTEYLL---PNHDQW 388
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 182-265 1.78e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 38.35  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 182 LNLSNCVAVHSLAHMYSLNQLALKAQDMIRRNFHKVIQDEEFYTLPFHLVRDWLSDSEITVDSEEILFETVLKWVQKNPE 261
Cdd:cd18465    1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80


                 ....
gi 959074889 262 ERER 265
Cdd:cd18465   81 RRAS 84
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-166 2.40e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 38.72  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  56 AHCSDLAWRQNEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLlsggFAESRSGRVELQKWSSEggpdSDT 135
Cdd:cd18213    3 SHSLVLLQQLNMQREFGFLCDCTVAIGDV----YFKAHRAVLAAFSNYFKMI----FIHQSSECIKIQPTDIQ----PDI 70

                         90       100       110
                 ....*....|....*....|....*....|.
gi 959074889 136 VEAVIGFMYTGTIRVSPGNvHEVLEMADRFL 166
Cdd:cd18213   71 FSYLLHIMYTGKGPKQSVD-HSRLEEGIRFL 100
PLN02193 PLN02193
nitrile-specifier protein
 382-522 2.79e-03

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 40.71  E-value: 2.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889 382 HAVAVTESYVYVAGSMEP-GFAKTVERYNPNRNIWEQVSN---LITRKHSFGLTEVKGNLYSIGGHGNFSpgFKDVAIYN 457
Cdd:PLN02193 272 HSMAADEENVYVFGGVSAtARLKTLDSYNIVDKKWFHCSTpgdSFSIRGGAGLEVVQGKVWVVYGFNGCE--VDDVHYYD 349

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 959074889 458 PEQDKWVNLES---APKILRDVKAVSVEDRFVYVAARTPVDSDSEDG---LRAVIIRYDAETRQWQDVESL 522
Cdd:PLN02193 350 PVQDKWTQVETfgvRPSERSVFASAAVGKHIVIFGGEIAMDPLAHVGpgqLTDGTFALDTETLQWERLDKF 420
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 424-468 3.05e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.05  E-value: 3.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 959074889  424 RKHSFGLTEVKGNLYSIGGHgNFSPGFKDVAIYNPEQDKWVNLES 468
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF-DGNQSLNSVEVYDPETNTWSKLPS 44
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 88-160 4.90e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 36.77  E-value: 4.90e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 959074889  88 REYRAHRSVLAAATEYFTPLLSGGFAESRSGRVELQKWSSEGgpdsdtVEAVIGFMYTGTIRVSPGNVHEVLE 160
Cdd:cd18319   11 RCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPG------LELVLDFINTSKVHESQGDSTDTLE 77
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-148 5.94e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 37.28  E-value: 5.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  66 NEQRRHGLYCDITLAFGGAgmarEYRAHRSVLAAATEYFTPLlsggFAESRSGRVELQKWSSEggpdSDTVEAVIGFMYT 145
Cdd:cd18193   13 NAQREFGFLCDCTVAIGDV----YFKAHKSVLASFSNYFKML----FVHQTSECVRLKPTDIQ----PDIFSYLLHLMYT 80


                 ...
gi 959074889 146 GTI 148
Cdd:cd18193   81 GKM 83
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 70-179 9.50e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 36.42  E-value: 9.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959074889  70 RHGLYCDITLAFGGAgmaREYRAHRSVLAAATEYFTPLLSGGFAesrsgrVELQKWSSEGgpdsdTVEAVIGFMYTGTIR 149
Cdd:cd18299    8 HSPSCADVVFILQGG---VRIFAHRIVLAAASSVFADLFLMMTV------VTLDSDITPE-----AFRRVLEFLYTGVLD 73

                         90       100       110
                 ....*....|....*....|....*....|
gi 959074889 150 VSPGNVHEVLEMADRFLLTRLKDFCGEFLK 179
Cdd:cd18299   74 ENEDDLKELKDAAELLELFDLVMMCTNVLN 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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