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Conserved domains on  [gi|951540421|ref|XP_014473166|]
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PREDICTED: microspherule protein 1 [Dinoponera quadriceps]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCRS_N pfam13325
N-terminal region of micro-spherule protein; This domain is found in plants and higher ...
 143-340 2.77e-138

N-terminal region of micro-spherule protein; This domain is found in plants and higher eukaryotes, and is the N-terminal region of micro-spherule proteins which repress the transactivation activities of Nrf1 (p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1). In conjunction with DIPA the full-length protein acts as a transcription repressor. The exact function of the region is not known.


:

Pssm-ID: 463845  Cd Length: 199  Bit Score: 395.50  E-value: 2.77e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951540421  143 RWKPTDDLALITGVQQTNDLRMVHRGTKFSCRFTLQEIQQRWYALLYDSAVSRVAVQAMRNLHPELIASVQARTLYSKAE 222
Cdd:pfam13325   1 RWKPTDDLALITAVQQTNDLRAVHRGVKFSCRFTLQEIQERWYALLYDPTISRIAVAAMRNLHPEVVASVQSKALFSQAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951540421  223 EDLLGTIKSTTHPSPETFQELLEANAHTFYPARTAKALQGHWQLMKQYHLLPDQTVQSLPRGEHV-LNFSDAEDMINDAD 301
Cdd:pfam13325  81 EQLLGTIKSSSQPTLETFQELLDKNADVFHPSRTAKSLQNHWQLMKQYGLLPDQSVQPLPKGDQVlLSFSDAEEQLNDSE 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 951540421  302 LIEPKDELVDAELTMADRKNKREIKVLENELGRWQVLVD 340
Cdd:pfam13325 161 LSEPRDEALEHELALADRKNKREIRLLENELSRWQVLVD 199
FHA_MCRS1 cd22687
forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; ...
 350-454 3.89e-60

forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; MCRS1, also called 58 kDa microspherule protein (MSP58), cell cycle-regulated factor p78, or INO80 complex subunit J, is a nuclear RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal ribonucleoparticles (mRNPs) from neurons. It is a cell-cycle-dependent protein that acts as an inhibitor of TERT telomerase activity. It associates with LPTS/PinX1 and reduces the telomere length. It modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex, MCRS1 may be involved in acetylation of nucleosomal histone H4 on several lysine residues. MCRS1 is also a putative regulatory component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication, and probably DNA repair. MCRS1 contains an FHA domain at its C-terminus. The FHA domain is a small phosphopeptide recognition module.


:

Pssm-ID: 438739 [Multi-domain]  Cd Length: 105  Bit Score: 191.99  E-value: 3.89e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951540421 350 FDNQTLAILRGRLVRYLMRSREISVGRTTKDHTVDVDLSLEGPAWKVSRRQGTIRLRNNGDFFLSSEGKRPIFVDSRPIL 429
Cdd:cd22687    1 FDSGALAVLRGRLVRYLMRSREVTIGRSTKDNQVDIDLSLEGPAWKISRRQAVIKLKNDGDFYIKNEGKRPIYVNGKPVP 80

                         90       100
                 ....*....|....*....|....*
gi 951540421 430 AGNKMKLNNNSVIEVAGLRFIFLIN 454
Cdd:cd22687   81 TGEKAILNNNSLIEIGGLRFVFLIN 105
 
Name Accession Description Interval E-value
MCRS_N pfam13325
N-terminal region of micro-spherule protein; This domain is found in plants and higher ...
 143-340 2.77e-138

N-terminal region of micro-spherule protein; This domain is found in plants and higher eukaryotes, and is the N-terminal region of micro-spherule proteins which repress the transactivation activities of Nrf1 (p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1). In conjunction with DIPA the full-length protein acts as a transcription repressor. The exact function of the region is not known.


Pssm-ID: 463845  Cd Length: 199  Bit Score: 395.50  E-value: 2.77e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951540421  143 RWKPTDDLALITGVQQTNDLRMVHRGTKFSCRFTLQEIQQRWYALLYDSAVSRVAVQAMRNLHPELIASVQARTLYSKAE 222
Cdd:pfam13325   1 RWKPTDDLALITAVQQTNDLRAVHRGVKFSCRFTLQEIQERWYALLYDPTISRIAVAAMRNLHPEVVASVQSKALFSQAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951540421  223 EDLLGTIKSTTHPSPETFQELLEANAHTFYPARTAKALQGHWQLMKQYHLLPDQTVQSLPRGEHV-LNFSDAEDMINDAD 301
Cdd:pfam13325  81 EQLLGTIKSSSQPTLETFQELLDKNADVFHPSRTAKSLQNHWQLMKQYGLLPDQSVQPLPKGDQVlLSFSDAEEQLNDSE 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 951540421  302 LIEPKDELVDAELTMADRKNKREIKVLENELGRWQVLVD 340
Cdd:pfam13325 161 LSEPRDEALEHELALADRKNKREIRLLENELSRWQVLVD 199
FHA_MCRS1 cd22687
forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; ...
 350-454 3.89e-60

forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; MCRS1, also called 58 kDa microspherule protein (MSP58), cell cycle-regulated factor p78, or INO80 complex subunit J, is a nuclear RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal ribonucleoparticles (mRNPs) from neurons. It is a cell-cycle-dependent protein that acts as an inhibitor of TERT telomerase activity. It associates with LPTS/PinX1 and reduces the telomere length. It modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex, MCRS1 may be involved in acetylation of nucleosomal histone H4 on several lysine residues. MCRS1 is also a putative regulatory component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication, and probably DNA repair. MCRS1 contains an FHA domain at its C-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438739 [Multi-domain]  Cd Length: 105  Bit Score: 191.99  E-value: 3.89e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951540421 350 FDNQTLAILRGRLVRYLMRSREISVGRTTKDHTVDVDLSLEGPAWKVSRRQGTIRLRNNGDFFLSSEGKRPIFVDSRPIL 429
Cdd:cd22687    1 FDSGALAVLRGRLVRYLMRSREVTIGRSTKDNQVDIDLSLEGPAWKISRRQAVIKLKNDGDFYIKNEGKRPIYVNGKPVP 80

                         90       100
                 ....*....|....*....|....*
gi 951540421 430 AGNKMKLNNNSVIEVAGLRFIFLIN 454
Cdd:cd22687   81 TGEKAILNNNSLIEIGGLRFVFLIN 105
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 372-428 4.24e-03

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 35.23  E-value: 4.24e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951540421   372 ISVGRTTKDHTVDVDLSlegpawKVSRRQGTIRLRNNGDFFL----SSEGkrpIFVDSRPI 428
Cdd:smart00240   1 VTIGRSSEDCDIQLDGP------SISRRHAVIVYDGGGRFYLidlgSTNG---TFVNGKRI 52
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 372-444 5.96e-03

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 35.24  E-value: 5.96e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 951540421  372 ISVGRTTkdhtvDVDLSLEGPawKVSRRQGTIRLRNNGDFFL----SSEGkrpIFVDSRPILaGNKMKLNNNSVIEV 444
Cdd:pfam00498   1 VTIGRSP-----DCDIVLDDP--SVSRRHAEIRYDGGGRFYLedlgSTNG---TFVNGQRLG-PEPVRLKDGDVIRL 66
 
Name Accession Description Interval E-value
MCRS_N pfam13325
N-terminal region of micro-spherule protein; This domain is found in plants and higher ...
 143-340 2.77e-138

N-terminal region of micro-spherule protein; This domain is found in plants and higher eukaryotes, and is the N-terminal region of micro-spherule proteins which repress the transactivation activities of Nrf1 (p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1). In conjunction with DIPA the full-length protein acts as a transcription repressor. The exact function of the region is not known.


Pssm-ID: 463845  Cd Length: 199  Bit Score: 395.50  E-value: 2.77e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951540421  143 RWKPTDDLALITGVQQTNDLRMVHRGTKFSCRFTLQEIQQRWYALLYDSAVSRVAVQAMRNLHPELIASVQARTLYSKAE 222
Cdd:pfam13325   1 RWKPTDDLALITAVQQTNDLRAVHRGVKFSCRFTLQEIQERWYALLYDPTISRIAVAAMRNLHPEVVASVQSKALFSQAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951540421  223 EDLLGTIKSTTHPSPETFQELLEANAHTFYPARTAKALQGHWQLMKQYHLLPDQTVQSLPRGEHV-LNFSDAEDMINDAD 301
Cdd:pfam13325  81 EQLLGTIKSSSQPTLETFQELLDKNADVFHPSRTAKSLQNHWQLMKQYGLLPDQSVQPLPKGDQVlLSFSDAEEQLNDSE 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 951540421  302 LIEPKDELVDAELTMADRKNKREIKVLENELGRWQVLVD 340
Cdd:pfam13325 161 LSEPRDEALEHELALADRKNKREIRLLENELSRWQVLVD 199
FHA_MCRS1 cd22687
forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; ...
 350-454 3.89e-60

forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; MCRS1, also called 58 kDa microspherule protein (MSP58), cell cycle-regulated factor p78, or INO80 complex subunit J, is a nuclear RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal ribonucleoparticles (mRNPs) from neurons. It is a cell-cycle-dependent protein that acts as an inhibitor of TERT telomerase activity. It associates with LPTS/PinX1 and reduces the telomere length. It modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex, MCRS1 may be involved in acetylation of nucleosomal histone H4 on several lysine residues. MCRS1 is also a putative regulatory component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication, and probably DNA repair. MCRS1 contains an FHA domain at its C-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438739 [Multi-domain]  Cd Length: 105  Bit Score: 191.99  E-value: 3.89e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951540421 350 FDNQTLAILRGRLVRYLMRSREISVGRTTKDHTVDVDLSLEGPAWKVSRRQGTIRLRNNGDFFLSSEGKRPIFVDSRPIL 429
Cdd:cd22687    1 FDSGALAVLRGRLVRYLMRSREVTIGRSTKDNQVDIDLSLEGPAWKISRRQAVIKLKNDGDFYIKNEGKRPIYVNGKPVP 80

                         90       100
                 ....*....|....*....|....*
gi 951540421 430 AGNKMKLNNNSVIEVAGLRFIFLIN 454
Cdd:cd22687   81 TGEKAILNNNSLIEIGGLRFVFLIN 105
FHA_FKH1-like cd22701
forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 ...
 355-453 1.37e-14

forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 (FKH1), 2 (FKH2) and similar proteins; This family includes FKH1 and FKH2, as well as pre-rRNA-processing protein FHL1. FKH1 and FKH2 are forkhead transcription factors that regulate the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle. The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20, as well as SWI5 and ACE2. FKH1 and FKH2 are involved in HMRa silencing. They associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing. Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation. They also function in controlling yeast cell morphology by preventing pseudohyphal growth and act as rate-limiting replication origin activators via their interaction with the origin recognition complex (ORC). FHL1 is a forkhead protein that controls the pre-rRNA processing machinery in conjunction with IFH1. It might act as a transcriptional regulator of genes specifically involved in that process. IFH1 convert FHL1 from a repressor to an activator. This family also includes AtFHA1 and AtFHA2, which may play a role in the control of plant organ development. AtFHA2 is specifically involved in the regulation of stamen development. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438753 [Multi-domain]  Cd Length: 106  Bit Score: 69.58  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951540421 355 LAILRGRLVRYLMRSREISVGRTTKD------HTVDVDLsleGPAWKVSRRQGTIRL-RNNGDFFLSSEGKRPIFVDSRP 427
Cdd:cd22701    2 YAKLDGDDFTYYVQKLEVVLGRNSKNssstaaDSVDIDL---GPSKKISRRHARIFYdFTTQCFELSVLGRNGVKVDGIL 78

                         90       100
                 ....*....|....*....|....*..
gi 951540421 428 ILAGNK-MKLNNNSVIEVAGLRFIFLI 453
Cdd:cd22701   79 VKPGSPpVPLRSGSLIQIGGVLFYFLL 105
FHA_FOXK cd22688
forkhead associated (FHA) domain found in the Forkhead box protein K (FOXK) subfamily; The ...
 355-425 3.26e-08

forkhead associated (FHA) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily includes two-winged helix transcription factors, FOXK1 and FOXK2. FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The Forkhead (FH) domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438740 [Multi-domain]  Cd Length: 100  Bit Score: 51.12  E-value: 3.26e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951540421 355 LAILRGRLVRYLMRSREISVGRTTKDHTVDVDLsleGPAWKVSRRQGTIRLrNNGDFFLSSEGKRPIFVDS 425
Cdd:cd22688    4 IARLEGREFEYLMRKSRVVIGRNSSRGPVDVNM---GHSSFISRKHLEIFY-EGGRFFLLCNGKNGIFVDG 70
FHA_FOXK2 cd22723
forkhead associated (FHA) domain found in forkhead box protein K2 (FOXK2) and similar proteins; ...
 353-424 1.79e-06

forkhead associated (FHA) domain found in forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, also called cellular transcription factor ILF-1, or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to HIV-1 long terminal repeat. FOXK2 may be involved in both positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438775 [Multi-domain]  Cd Length: 111  Bit Score: 46.44  E-value: 1.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951540421 353 QTLAILRGRLVRYLMRSREISVGRTTKDHTVDVDLsleGPAWKVSRRQ--------GTIRLRNNGDFFLSSEGKRPIFVD 424
Cdd:cd22723    2 PAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSM---GHSSFISRRHleiftageDGGDGGGGGDFYLRCLGKNGVFVD 78
FHA_Ki67 cd22673
forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar ...
 364-451 2.72e-06

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438725 [Multi-domain]  Cd Length: 95  Bit Score: 45.67  E-value: 2.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951540421 364 RYLMRSREISVGRttkDHTVDVDLSLEGpawkVSRRQGTIRLRNNGDFFLSSEGK-RPIFVDSRPILagNKMKLNNNSVI 442
Cdd:cd22673   15 RFPLTKKSCTFGR---DLSCDIRIQLPG----VSREHCRIEVDENGKAYLENLSTtNPTLVNGKAIE--KSAELKDGDVI 85


                 ....*....
gi 951540421 443 EVAGLRFIF 451
Cdd:cd22673   86 TIGGRSFRF 94
FHA_APTX-like cd22671
forkhead associated (FHA) domain found in aprataxin, bifunctional polynucleotide phosphatase ...
 365-451 5.12e-05

forkhead associated (FHA) domain found in aprataxin, bifunctional polynucleotide phosphatase/kinase (PNKP), aprataxin and PNK-like factor (APLF), and similar proteins; The family includes aprataxin, PNKP, and APLF. Aprataxin (EC 3.6.1.71/EC 3.6.1.72), also called forkhead-associated domain histidine triad-like protein (FHA-HIT), is a DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair, and base excision repair. It catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. It can also hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. Likewise, it catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA but has higher specific activity with 5'-linked adenosine (AppDNA). PNKP (EC 3.1.3.32/EC 2.7.1.78), also called DNA 5'-kinase/3'-phosphatase, or polynucleotide kinase-3'-phosphatase, plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNKP ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. APLF, also called apurinic-apyrimidinic endonuclease APLF, PNK and APTX-like FHA domain-containing protein, or XRCC1-interacting protein 1 (XIP1), is a novel apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease with conserved zinc-finger-like motifs involved in single-strand and double-strand DNA break repair. It is recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. It can introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Together with PARP3, APLF promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Members of this family contain an FHA domain at their N-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438723 [Multi-domain]  Cd Length: 101  Bit Score: 42.30  E-value: 5.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951540421 365 YLMRSREISVGRTtkDHTVDVDLslegpawKVSRRQGTIRLRNNGD-FFLSSEGKRPIFVDS-----RPILAGNKMKLNN 438
Cdd:cd22671   14 ELKEGGPTVLGRG--PLLGIRDK-------RVSRKQAEITVDDDTGsVTVTQLGTNPSFVNRadgegKVLKKGESVELKD 84

                         90
                 ....*....|...
gi 951540421 439 NSVIEVAGLRFIF 451
Cdd:cd22671   85 GDVISLLPGKYPF 97
FHA_FOXK1 cd22722
forkhead associated (FHA) domain found in forkhead box protein K1 (FOXK1) and similar proteins; ...
 353-424 5.42e-05

forkhead associated (FHA) domain found in forkhead box protein K1 (FOXK1) and similar proteins; FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of the myoglobin gene. It positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438774  Cd Length: 103  Bit Score: 42.19  E-value: 5.42e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 951540421 353 QTLAILRGRLVRYLMRSREISVGRTTKDHTVDVDLsleGPAWKVSRRQGTIRLRNNgDFFLSSEGKRPIFVD 424
Cdd:cd22722    2 PALARLEGRDFEFLMRQPTVTIGRNSSQGSVDVNM---GHSSFISRRHLQLSFQEP-HFYLRCLGKNGVFVD 69
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 372-428 4.24e-03

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 35.23  E-value: 4.24e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951540421   372 ISVGRTTKDHTVDVDLSlegpawKVSRRQGTIRLRNNGDFFL----SSEGkrpIFVDSRPI 428
Cdd:smart00240   1 VTIGRSSEDCDIQLDGP------SISRRHAVIVYDGGGRFYLidlgSTNG---TFVNGKRI 52
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 372-444 5.96e-03

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 35.24  E-value: 5.96e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 951540421  372 ISVGRTTkdhtvDVDLSLEGPawKVSRRQGTIRLRNNGDFFL----SSEGkrpIFVDSRPILaGNKMKLNNNSVIEV 444
Cdd:pfam00498   1 VTIGRSP-----DCDIVLDDP--SVSRRHAEIRYDGGGRFYLedlgSTNG---TFVNGQRLG-PEPVRLKDGDVIRL 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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