|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
10-439 |
0e+00 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 656.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTL 169
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 170 SISGFICMGTSFVCLVLIKNEPSDVGLPNIEPGTTKGK-KGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQ 248
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKkKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 249 LFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAVARVGLSLYGNPRHVLLLSMMAGMSVSMYLFRVTITSDSPk 328
Cdd:cd17343 241 LFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSS- 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 329 ennfwivalhplaaltgfteqELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLAGLPFST 408
Cdd:cd17343 320 ---------------------ELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSY 378
|
410 420 430
....*....|....*....|....*....|.
gi 946652444 409 IAKHYSWATAFWVAEITCAISTVAFFLLRNI 439
Cdd:cd17343 379 IAKHYDWRTAFLLLEILCAITVVILFLLRNI 409
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
18-419 |
8.76e-133 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 387.50 E-value: 8.76e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 18 FVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWS 97
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 98 STVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP-IVAALMALSYDWRTTLSISGFIC 176
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 177 MGTSFVCLVLIKNEPSDVGLPNIEP--------GTTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQ 248
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEmpneepdgDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 249 LFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSMMAGMSVSMYLFRVTITSDspk 328
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDK--------LFNGRRGPLAVFFMALIIVSLLVYWLNPAAN--- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 329 ennfwivalhplaaltgfteqELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLAGLPFST 408
Cdd:TIGR00881 310 ---------------------PLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGY 368
|
410
....*....|.
gi 946652444 409 IAKHYSWATAF 419
Cdd:TIGR00881 369 LADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
10-437 |
7.97e-109 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 326.15 E-value: 7.97e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTL 169
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 170 SISGFICMGTSFVCLVLIKNEPsdvglpniepgttkgkkglsgdhstlaelllsPYLWVLSSGYLVVFGVKTCCTDWGQL 249
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSP--------------------------------PYVWVLSLAYAFVYIVRYACLDWGPL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 250 FLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSMMAGMSVSMYLFRVTITSdspke 329
Cdd:cd17312 209 YLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDK--------LFGGRRAPIAVIYMLLMTLSLALFWFFPHN----- 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 330 nnfwivalhplaaltgfteqELWILILGAIFGFSSYGPIALFGVIANE-SAPSNLCGTSHAIVALMANVGGFLAGLPFST 408
Cdd:cd17312 276 --------------------KLLSIVLLFLIGFFVGGPINLIGGAAAQdIGRKEAAGTATGFVGLFGYLGASLAGLPLGY 335
|
410 420
....*....|....*....|....*....
gi 946652444 409 IAKHYSWATAFWVAEITCAISTVAFFLLR 437
Cdd:cd17312 336 IIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
2-436 |
1.52e-77 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 248.09 E-value: 1.52e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 2 MDKGYSYYRTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFS 81
Cdd:PRK11663 13 IDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 82 SGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMAL 161
Cdd:PRK11663 93 IGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIAL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 162 SYDWRTTLSISGFICMGTSFVCLVLIKNEPSDVGLPNI--------EPGTTKGKKGLSGDHSTLAELLLSPYLWVLSSGY 233
Cdd:PRK11663 173 HYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVgewrhdalELAQQQEGAGLSRKEILTKYVLLNPYIWLLSFSY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 234 LVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSMMAGMSV 313
Cdd:PRK11663 253 VLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDK--------LFNGNRGPMNLIFAAGILL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 314 SMylfrvtitsdspkeNNFWivaLHPLAAltgfteqelWILILGAIF--GFSSYGPIALFGVIANESAPSNLCGTSHAIV 391
Cdd:PRK11663 325 SV--------------GSLW---LMPFAS---------YVMQAACFFtiGFFVFGPQMLIGMAAAECSHKEAAGAATGFV 378
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 946652444 392 ALMANVGGFLAGLPFSTIAKHYSWATAFWVaeITCAISTVAFFLL 436
Cdd:PRK11663 379 GLFAYLGAALSGYPLAKVLEIWHWTGFFVV--ISIAAGISALLLL 421
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
10-436 |
1.52e-67 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 219.97 E-value: 1.52e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTL 169
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 170 SISGFICMGTSFVCLVLIKNEPsdvglpniepgttkgkkglsgdhstlaelllsPYLWVLSSGYLVVFGVKTCCTDWGQL 249
Cdd:cd17488 161 YVPGIIAILMGIVLCWRLRDRP--------------------------------PYIWLLAFCYVLVYVVRTAINDWGNL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 250 FLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSMMAGMSVSMYLFRVTitsdspKE 329
Cdd:cd17488 209 YLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDK--------LFKGNRGPMNLIFALGLLVSVGALWLV------PV 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 330 NNFWIVAlhplaaltgfteqelwilILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLAGLPFSTI 409
Cdd:cd17488 275 HSYWLLA------------------TCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKV 336
|
410 420
....*....|....*....|....*..
gi 946652444 410 AKHYSWATAFWVAEITCAISTVAFFLL 436
Cdd:cd17488 337 IESWGWSGFFIVISIAAAISGLLLLPL 363
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
10-437 |
2.75e-63 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 210.18 E-value: 2.75e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 90 VNVVF----SWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMA---LS 162
Cdd:cd17345 81 INILIgfvpSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLaifGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 163 YDWRTTLSISGFICMGTSFVCLVLIKNEPSDVGLPNIE---------PGTTKGKKGLSGDHSTLAELLLSPYLWVLS--- 230
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEeykgdypeeADGEEEEQELSAWEIFVKYVLKNKLLWYIAian 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 231 -SGYLVVFGVktccTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglsLYGNPRhvlllsMMA 309
Cdd:cd17345 241 vFVYLVRYGI----LDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDK--------LFKGRR------APT 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 310 GMsVSMYLFRVTITSdspkennFWivalhplaaltgFTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHA 389
Cdd:cd17345 303 GI-IFMILVIVALIV-------YW------------LAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAG 362
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 946652444 390 IVALMANVGG-FLAGLPFSTIAKHYSWATAFWVAEITCAISTVAFFLLR 437
Cdd:cd17345 363 LTGLFGYLGGsVLATALIGIIVDHFGWNGGFIVLLASCILAIIFLALVA 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-437 |
8.37e-54 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 183.92 E-value: 8.37e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 3 DKGYSYYRTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSS 82
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 83 GLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALS 162
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 163 YDWRTTLSISGFICMgtsfvclvliknepsdvglpniepgttkgkkglsgdhstlaeLLLSPYLWVLSSGYLVVFGVKTC 242
Cdd:COG2271 161 FGWRAAFLILGLPGL------------------------------------------LLALLRFWLLALAYFLVYFALYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 243 CTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglslYGNPRHVLLLSMMAGMSVSMYLFrvti 322
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---------LGRRRKLVLAIGLLLAALALLLL---- 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 323 tsdspkennfwivalhplaaltGFTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLA 402
Cdd:COG2271 266 ----------------------ALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALG 323
|
410 420 430
....*....|....*....|....*....|....*
gi 946652444 403 GLPFSTIAKHYSWATAFWVAEITCAISTVAFFLLR 437
Cdd:COG2271 324 PLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
2-436 |
3.69e-45 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 162.70 E-value: 3.69e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 2 MDKGYSYYRTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEiELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFS 81
Cdd:TIGR00712 17 IDPTYKRLRWQVFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSKGELGFALSAISIAYGFSKFIMGSVSDRSNPRVFLP 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 82 SGLLLVGIVN---VVFSW-SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGG-LGPIVA 156
Cdd:TIGR00712 96 AGLILSAAVMllmGFVPWaTSSIAIMFVLLFLNGWFQGMGWPPCGRTMVHWWSQSERGTIVSIWNCAHNIGGGiPPLLVL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 157 ALMALSYDWRTTLSISGFICMGTSFVCLVLIKNEPSDVGLPNIEP--------GTTKGKKGLSGDHSTLAELLLSPYLWV 228
Cdd:TIGR00712 176 LGMAWFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIEEyrndypddYNEKAEQELTAKEIFMQYVLPNKLLWY 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 229 LSSGYLVVFGVKTCCTDWGQLFLIQERGqSALVGSSYMSAL-EIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSM 307
Cdd:TIGR00712 256 IAIANVFVYLLRYGVLDWSPTYLKEVKH-FALDKSSWAYFLyEYAGIPGTLLCGWMSDK--------VFKGNRGATGVFF 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 308 MAGMSVSMYLfrvtitsdspkennFWI-VALHPLaaltgfTEQELWILIlgaifGFSSYGPIALFGVIANESAPSNLCGT 386
Cdd:TIGR00712 327 MTLVTIAVIV--------------YWMnPAGNPL------VDMICMIVI-----GFLIYGPVMLIGLHALELAPKKAAGT 381
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 946652444 387 SHAIVALMANVGGFL-AGLPFSTIAKHYSWATAFWVAeITCAISTVAFFLL 436
Cdd:TIGR00712 382 AAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMVM-IGGSILAVILLIV 431
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
2-431 |
9.97e-36 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 137.15 E-value: 9.97e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 2 MDKGYSYYRTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEiELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFS 81
Cdd:PRK11273 19 IDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 82 SGLLLVGIVNVVFSW----SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGL-GPIVA 156
Cdd:PRK11273 98 AGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLpPLLFL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 157 ALMALSYDWRTTLSISGFICMGTSFVCLVLIKNEPSDVGLPNIEPG--------TTKGKKGLSGDHSTLAELLLSPYLWV 228
Cdd:PRK11273 178 LGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYkndypddyNEKHEQELTAKQIFMQYVLPNKLLWY 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 229 LSSGYLVVFGVKTCCTDWGQLFLiQERGQSALVGSSYMSAL-EIGGLVGSIAAGYLSDRAvarvglsLYGNprhvlllsm 307
Cdd:PRK11273 258 IAIANVFVYLLRYGILDWSPTYL-KEVKHFALDKSSWAYFLyEYAGIPGTLLCGWMSDKV-------FRGN--------- 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 308 mAGMSVSMYLFRVTITSDSpkennFWivaLHPlaalTGFTEQELWILIlgaIFGFSSYGPIALFGVIANESAPSNLCGTS 387
Cdd:PRK11273 321 -RGATGVFFMTLVTIATIV-----YW---LNP----AGNPTVDMACMI---VIGFLIYGPVMLIGLHALELAPKKAAGTA 384
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 946652444 388 HAIVALMANVGGFLAGlpfSTI----AKHYSWATAFWVAEITCAISTV 431
Cdd:PRK11273 385 AGFTGLFGYLGGSVAA---SAIvgytVDFFGWDGGFMVMIGGSILAVI 429
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-437 |
4.89e-33 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 128.46 E-value: 4.89e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 9 YRTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVG 88
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 89 IVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTT 168
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 169 LSISGFICMGTSFVCLVLIKNEPSDVGLPNiepgttkgkkglSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQ 248
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAAA------------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 249 LFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglslygnPRHVLLLSMMAGMSVSMYLFrvtitsdspk 328
Cdd:COG2223 230 PYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-----------GGRRVLLIVFALMALGLLLL---------- 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 329 ennfwIVALHPLAALTGFteqelwILILGAIFGFssyGPIALFGVIANESAPSNLcGTSHAIVALMANVGGFLAGLPFST 408
Cdd:COG2223 289 -----ALALGSLWLFLVL------FLLLGLALGG---GNGAVFALVPDIFPTKNA-GAVYGLVGAAGGLGGFLGPLLFGA 353
|
410 420 430
....*....|....*....|....*....|
gi 946652444 409 IAKHY-SWATAFWVAEITCAISTVAFFLLR 437
Cdd:COG2223 354 LLDATgSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-402 |
2.56e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 109.04 E-value: 2.56e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 17 MFVGYTLYYFNRKTFSFVMP-AIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFS 95
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 96 WSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFI 175
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 176 CMGTSFVCLVLIKNEPSdvglpniePGTTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVkTCCTDWGQLFlIQER 255
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES--------KRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAF-FGLLTYLPLY-QEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 256 GQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglslygnPRHVLLLSMMAGMSVSMYLFrvtitsdspkennfwiv 335
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL-----------GRRRRLLLALLLLILAALGL----------------- 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 946652444 336 alhplaALTGFTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLA 402
Cdd:pfam07690 283 ------LLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-436 |
5.52e-26 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 108.04 E-value: 5.52e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTL 169
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 170 SISGFICMGTSFVCLVLIknePSDVGLpniepgttkgkkglsgdhsTLAELLLSPYLWVLSSgylvvfgvktcctdWGQL 249
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL---RQVWGL-------------------ALGYFGINYALYGLLT--------------WLPT 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 250 FLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglsLYGNPRHVLLLSMMAGMSVSMYLFrvtitsdspke 329
Cdd:cd17319 205 YLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDR--------LLRGARRLVIIIGLLLAAVGLLLA----------- 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 330 nnfwivalhplaaltGFTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLAGLPFSTI 409
Cdd:cd17319 266 ---------------YLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYL 330
|
410 420
....*....|....*....|....*...
gi 946652444 410 AKH-YSWATAFWVAEITCAISTVAFFLL 436
Cdd:cd17319 331 VDAtGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-402 |
3.76e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 105.83 E-value: 3.76e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 7 SYYRTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLL 86
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 87 VGIVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWR 166
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 167 TTLSISGFICmgtsFVCLVLIKnepsdVGLPNIEPGTTKGKKGlsgdhsTLAELLLSPYLWVLSSGYLVVFGVKTCCTDW 246
Cdd:COG2814 165 WVFLVNAVLA----LLALLLLL-----RLLPESRPAARARLRG------SLRELLRRPRLLLLLLLAFLLGFGFFALFTY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 247 GQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglslygnPRHVLLLSMMAGMSVSMYLFrvtitsds 326
Cdd:COG2814 230 LPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-----------GRRRLLLIGLLLLALGLLLL-------- 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 946652444 327 pkennfwivalhplaaltGFTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLA 402
Cdd:COG2814 291 ------------------ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-434 |
6.72e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 102.50 E-value: 6.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 17 MFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSW 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 97 SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAAL--MALSYDWRTTLSISGF 174
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIlaSSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 175 ICMGTSFVCLVLIKNEPSDVGLPNIEPGTTKGKKGLSgdhstlaELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLIQE 254
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLK-------RVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 255 RGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglslyGNPRHVLLLSMMAGMSVSMylfrvtitsdspkennfwi 334
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR----------LIGRKPLLLIGLLLMALGL------------------- 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 335 valhplaALTGFTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLAGLPFSTI-AKHY 413
Cdd:cd06174 285 -------ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATF 357
|
410 420
....*....|....*....|.
gi 946652444 414 SWATAFWVAEITCAISTVAFF 434
Cdd:cd06174 358 GLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
36-437 |
1.84e-20 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 92.69 E-value: 1.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 36 PAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQG 115
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 116 LGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLVLIKNEPsdvg 195
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPP---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 196 lpniEPGTTKGKKglSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGGLV 275
Cdd:cd17475 176 ----AASAATESA--STLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 276 GSIAAGYLSDRAVArvglslyGNPRHVLLLSMMAGMSVSmylfrvTITSDSPKENNFWIVALhplaaltgfteqeLWILi 355
Cdd:cd17475 250 GRIGLGRVSDRVFG-------GRRRPVLVITAAIAAAAL------LVLSLLSPGTPLWLLVL-------------LLIL- 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 356 lgaiFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLAGLPF-STIAKHYSWATAFWVAeitCAISTVAFF 434
Cdd:cd17475 303 ----LGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFgLLVDATHSYAPAWLAL---ALLLVLAAL 375
|
...
gi 946652444 435 LLR 437
Cdd:cd17475 376 LLL 378
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
14-293 |
5.61e-18 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 85.87 E-value: 5.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 14 FTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVV 93
Cdd:PRK09556 31 YLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 94 FSWS-----STVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMAlsydwrTT 168
Cdd:PRK09556 111 FGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGA------NY 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 169 L---SISGF------ICMGTSFVCLVLIKNEPSDVGLPNIEP--GTTKGKKGLSGDHSTLAE-------LLLSPYLWVLS 230
Cdd:PRK09556 185 FfdgHVIGMfifpsiIALIIGFIGLRYGSDSPEELGWGKAEEifGEPISEEDKETESTDMTKwqifveyVLKNPVIWLLC 264
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 946652444 231 SGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAVARVGL 293
Cdd:PRK09556 265 FANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGRRAL 327
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-437 |
3.86e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 82.62 E-value: 3.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 13 IFTAMFVGYTLYYfnrkTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNV 92
Cdd:cd17325 1 LSLALFLDMLGYG----IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 93 VFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLsis 172
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF--- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 173 gFICMGTSFVCLVLIKnepsdVGLPNIEPGTTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLI 252
Cdd:cd17325 154 -LVCAALALLALVLAL-----LLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 253 QERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglslygnPRHVLLLSMMAGMSVSMYLFRVTitsdspkeNNF 332
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-----------GRKPLILIGLLLSAVALLLLPLA--------TSF 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 333 WIVALhpLAALTGfteqelwiliLGAIFGFSSYGPIalfgvIANESAPSNLcGTSHAIVALMANVGGFLAGLPFSTIAKH 412
Cdd:cd17325 289 WLLLL--LLALLG----------LGLGLVFPATLAL-----LADIVPPEGR-GTAMGLFNTAFSLGMVLGPLLGGFLYDA 350
|
410 420
....*....|....*....|....*
gi 946652444 413 YSWATAFWVAEITCAISTVAFFLLR 437
Cdd:cd17325 351 FGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
28-434 |
6.23e-16 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 79.24 E-value: 6.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 28 RKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLW 107
Cdd:cd17355 19 RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 108 FLNGLAQ--GLGWPPCGKVLRKWFEPSQfGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLV 185
Cdd:cd17355 99 GLLGGGGagTLAAVAFATVAAWWFERRR-GLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 186 LIKNEPSDVGLPNIEPGTTKGKKglsgdhSTLAELLLSPYLWVLSSGYLVVfGVKTCCTDWGQLFLIQERGQSALVGSSY 265
Cdd:cd17355 178 LLRRRPADLALRAYDDASPASPG------STLKEALRSASFWLLALAFFLC-GFAVVGLIVHLVPYLADRGISPAAAAVA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 266 MSALEIGGLVGSIAAGYLSDRavarvglslyGNPRHVLLLSMMAGMSVsmylfrvtitsdspkennfwivalhpLAALTG 345
Cdd:cd17355 251 LALIGLFNIVGRLLSGWLGDR----------YSPRRLLAASYALRALG--------------------------LALLLL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 346 FTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLAGLPFSTIAKHY-SWATAFWVAEI 424
Cdd:cd17355 295 LPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgSYTAAWALAVA 374
|
410
....*....|
gi 946652444 425 TCAISTVAFF 434
Cdd:cd17355 375 LGLIAALLVL 384
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-436 |
1.68e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.99 E-value: 1.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 34 VMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 114 QGLGWPPCGKVLRKWFePSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLVLIKNEPSD 193
Cdd:COG2807 120 IAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 194 vglpniepgttkgkKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLiQERGQSALVGSSYMSALEIGG 273
Cdd:COG2807 199 --------------AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 274 LVGSIAAGYLSDRAVARVGLSLygnprhVLLLSMMAGmsvsmylfrvtitsdspkennFWIVALHPLAALTgfteqeLWI 353
Cdd:COG2807 264 IPGSLLVPLLADRLGDRRPLLL------LLGLLGLAG---------------------LLGLLLAPGSLPW------LWA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 354 LILGAIFGFSSYGPIALFGVIANESAP-SNLCGTSHAIVALMANVGGFLAGLPFSTIAkhySWATAFWVAEITCAISTVA 432
Cdd:COG2807 311 VLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATG---SWTAALLLLAALAVLMLVA 387
|
....
gi 946652444 433 FFLL 436
Cdd:COG2807 388 GLLA 391
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
34-437 |
1.70e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.73 E-value: 1.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 34 VMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:COG0738 30 LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 114 QGLGWPPCGKVLRkWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMA---LSYDWRTTLSISGFICMGTSFVCLVlikne 190
Cdd:COG0738 110 LGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLIllgLSLSWHLPYLILAVLLLLLALLFLR----- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 191 psdVGLPNIEPGTTKGkkglSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALE 270
Cdd:COG0738 184 ---SKLPEIEEEEEEA----AGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 271 IGGLVGSIAAGYLSDRAvarvglslygNPRHVLLLSMMAGMsVSMYLFrvtitsdspkennfwIVALHPLAALTGFteqe 350
Cdd:COG0738 257 GGMTIGRFLGGFLLKRF----------GPVRLLRLSALLAA-VGLLLA---------------LLAPGPWLALIGL---- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 351 lwiLILGaiFGFSSYGPIALfgVIANESAPSNLCGTShAIVALMANVGGFLAGLPFSTIAKHYSWATAFWVAEITCAIST 430
Cdd:COG0738 307 ---ALVG--LGLSLMFPTIF--SLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLIL 378
|
....*..
gi 946652444 431 VAFFLLR 437
Cdd:COG0738 379 LLALALK 385
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
10-158 |
5.42e-12 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 66.95 E-value: 5.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEE---------------------IELDKDD----LGLITSSQSAAYAISK 64
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEwtpsnsntsielheetwnanpLFPSQDDaalfLGVLDTIFLFSYAIGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 65 FISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVF------SGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWW 138
Cdd:cd17342 81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFynkylyCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160
|
170 180
....*....|....*....|
gi 946652444 139 AILSTSMNLAGGLGPIVAAL 158
Cdd:cd17342 161 GLWSACASVGNIIGALLASS 180
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
10-191 |
1.43e-11 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 65.80 E-value: 1.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 10 RTVIFTAMFVGYTLYYFNRKTFSFV-----------MPAIMEEIE---------LDKDD----LGLITSSQSAAYAISKF 65
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVksvlhpncsalIPPPNIVLNnttwcgwapFDGKNgtelLGALDSAFLFAYAIGMF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 66 ISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSgLWF------LNGLAQGLGWPPCGKVLRKWFEPSQFGTWWA 139
Cdd:cd17344 81 FSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHS-LWYfvvvqiLAGLFQSTGWPSVVACVGNWFGKGKRGLIMG 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 946652444 140 ILSTSMNLAGGLGPIVAAlMALSYDWRTTLSISGFICMGTSFVC-LVLIKNEP 191
Cdd:cd17344 160 IWNSHTSVGNILGSLIAG-IFVSSAWGLSFIVPGIIIAAMGVLVfLFLVEHPP 211
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
14-434 |
6.73e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.79 E-value: 6.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 14 FTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVV 93
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 94 FSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMA-LSYDWRTTLSIS 172
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 173 GFIcmgtSFVCLVLIKnepsdVGLPNIEPGTTKGKKGLSGDHSTLAELLLS-----PYLWVLSSGYLVVFGVkTCCTDWG 247
Cdd:cd17328 161 GVL----GVLLAILLL-----LFVREPPRGAAEGGVMAKSTATSFLADLKAlaknpSFILSTLGFTAVSFVT-GALAFWA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 248 QLFLiqERGQSALVGSSYMSALE------IGGLVGSIAAGYLSDRAVARvglslygNPRHVLLLSMMaGMSVSMYLFRVT 321
Cdd:cd17328 231 PTFF--LRAFGVGDLSSADVGLIfgaitcIAGVLGVLLGGILADRLRRK-------TPRADPLVCAV-GLLAAAPFLFLA 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 322 ITSDSPKENNFWIvalhplaaltgfteqelwILILGAIFGFSSYGPIAlfgVIANESAPSNLCGTSHAIVALMAN----- 396
Cdd:cd17328 301 LVLALSNLLLAWV------------------LLFLGEFLLSLNWAPVF---AILLYVVIPTRRSTASAIQILLSHllgda 359
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 946652444 397 VGGFLAGLPFSTIAKHY--------SWATAFWVAEITCAISTVAFF 434
Cdd:cd17328 360 GSPYLIGLISDLLRQNKdsplaeaaSLQYALLLCSFVLVLGGFFFL 405
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-436 |
6.86e-11 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 63.86 E-value: 6.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 14 FTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVV 93
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 94 FSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMA----LSYDWRTTL 169
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFpllpPEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 170 SISGFicmgTSFVCLVLIKNEPsdvglpniEP---GTTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCC--- 243
Cdd:cd17371 161 LLGAL----PALLVLFIRRFVK--------EPpqwQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYygi 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 244 TDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglslYGNPRHVLLLSMMAGMSVSMYLFrvtit 323
Cdd:cd17371 229 TTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADR---------IGRRNNFALFALGSAISILLYFF----- 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 324 sdspkennfwivalhplaaLTGFTEQelwILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLAG 403
Cdd:cd17371 295 -------------------LPLSPTL---ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFP 352
|
410 420 430
....*....|....*....|....*....|....
gi 946652444 404 LPFSTIAKHYSWATAF-WVAEITCAISTVAFFLL 436
Cdd:cd17371 353 FLVGFLATSGSLGTAIaVFAAVYYIAGLVLALLL 386
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-434 |
1.15e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 62.96 E-value: 1.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 34 VMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 114 QGLGWPPCGKVLRKwFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLVLIKnepsd 193
Cdd:cd17478 98 SAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 194 VGLPNIEPGTTKGKKGLSGDHSTLAELLLspyLWVLSSGYLVVFGVKTCCTdwgqlFLIQERGQSALVGSSYMSALEIGG 273
Cdd:cd17478 172 LKKPEAKKAAAKSSARSTLKGVWRALLLL---LIIVFLRSWVLSSLTTFLP-----FYLVQRGYSLVFAGLLLSLFLFAG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 274 LVGSIAAGYLSDRavarvglslyGNPRHVLLLSmMAGMSVSMYLFRVTitsdspkennfwivalhplaaltgfteQELWI 353
Cdd:cd17478 244 AIGTLIGGPLSDR----------FGRRRVIIAS-LLLAAPFLLLFLLT---------------------------PGIWS 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 354 LILGAIFGFSSYGPIALFGVIANESAPSNLcGTSHAIVALMANVGGFLAGLPFSTIAKHYSWATAFWVAEITCAISTVAF 433
Cdd:cd17478 286 YILLVLAGFLLFASFPVTVVLAQELLPGNV-GLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLA 364
|
.
gi 946652444 434 F 434
Cdd:cd17478 365 F 365
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-239 |
1.37e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 62.14 E-value: 1.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 10 RTVIFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTL 169
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 170 SISGFIcmgtSFVCLVLIKNEPSDVGLPNIEPGTTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGV 239
Cdd:COG0477 172 LINAPL----GLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGA 237
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
34-436 |
2.02e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 59.12 E-value: 2.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 34 VMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 114 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALsYDWRTTLSISgFICMGTSFVCLVLIKNEPSd 193
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLL-AALIPVAFLAILFLLPEPK- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 194 vglpniepgtTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGG 273
Cdd:cd17474 178 ----------EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 274 LVGSIAAGYLSDRAVarvglslygnPRHVLLLSMMAGMSVSMYLFrvtitsdspkennfwivalhplaaltGFTEQELWI 353
Cdd:cd17474 248 ALGSLFVGRLLKKRF----------GARRILVIGLLLYALSLLLL--------------------------GFVPSLALL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 354 LILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLAGLPFSTIAKHYSWATAFWVAEITCAISTVAF 433
Cdd:cd17474 292 LIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
...
gi 946652444 434 FLL 436
Cdd:cd17474 372 ALL 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
32-404 |
2.88e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 58.52 E-value: 2.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 32 SFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNG 111
Cdd:TIGR00895 37 GFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 112 LAQGLGWPPCgKVLRKWFEPSQF-GTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFIcmgTSFVCLVLIKNE 190
Cdd:TIGR00895 117 LGLGGLMPNL-NALVSEYAPKRFrGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIA---PLLLLLLLMRFL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 191 P----------------------------SDVGLPnIEPGTTKGKKGLSGDHSTLAELLLSPYLWVLSS-GYLVVFGVkt 241
Cdd:TIGR00895 193 PesidflvskrpetvrrivnaiapqmqaeAQSALP-EQKSTQGTKRSVFKALFQGKTARITVLLWLLYFmLLVGVYFL-- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 242 ccTDWGQlFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglslygNPRHVLLLSMMAGMSVSMYLFRVT 321
Cdd:TIGR00895 270 --TNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL----------GPRVTALLLLLGAVFAVLVGSTLF 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 322 ITSDspkennfwivalhplaaltgfteqelwILILGAIFGFSSYGPIALFGVIANESAPSNLCGTShaiVALMANVGGFL 401
Cdd:TIGR00895 337 SPTL---------------------------LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATG---VGWAIGIGRLG 386
|
...
gi 946652444 402 AGL 404
Cdd:TIGR00895 387 AII 389
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-434 |
6.98e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 57.17 E-value: 6.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 34 VMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:cd17324 21 LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 114 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLVLIknepsd 193
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 194 vglpniePGTTKGKKGLSGDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGG 273
Cdd:cd17324 175 -------PSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 274 LVGSIAAGYLSDRAVARVglslygnprhvlLLSMMAGMSVSMYLfrvtitsdspkennFWIVALHPLAALTGFteqelwi 353
Cdd:cd17324 248 VVGSPLAGRLADRGGRRA------------LLIALLLLAAALLL--------------LTLLGPSPLLLLVGL------- 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 354 lilgAIFGFSSYGPIALFGVIANESAPSNLcGTSHAIVALMANVGGFLAGLPFSTIAKHYSWATAFWVAEITCAISTVAF 433
Cdd:cd17324 295 ----VLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
.
gi 946652444 434 F 434
Cdd:cd17324 370 L 370
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-434 |
2.61e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 55.30 E-value: 2.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 14 FTAMFVGYTLYYFNRKTFSFVMPAIMEEIE--LDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVN 91
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 92 VVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMN----LAGGLGPIVAALMALSYDWRT 167
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAlgalLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 168 TLSISGFICMGTsfvclvliknepsdvglpniepgttkgkkglsgdhstlaeLLLSPYLWVLSSGYLVVFGVKTCCTDWG 247
Cdd:cd17316 161 LFLIGALPALLA----------------------------------------LLLRRRTLLLILLWFFISFGYYGLTTFL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 248 QLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAvarvglslygnPRHVLLLSMMAGMSVSMYLFrvtitsdsp 327
Cdd:cd17316 201 PTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-----------GRKKTLVIGLILSGILALPL--------- 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 328 kennfwivalhplaaLTGFTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMAN-VGGFLAGLPF 406
Cdd:cd17316 261 ---------------FYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRlGGGGAPPLIA 325
|
410 420
....*....|....*....|....*...
gi 946652444 407 STIAKHYSWATAFWVAEITCAISTVAFF 434
Cdd:cd17316 326 LLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-188 |
8.39e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.11 E-value: 8.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 12 VIFTAMFVGYTLYYFNRKTFSFVMPAIM-EEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSAR--WLFSSGLLLVG 88
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLvEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 89 IVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTT 168
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|
gi 946652444 169 LSISGFICMGTSFVCLVLIK 188
Cdd:COG2271 340 FLLLAALALLAALLALLLLR 359
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
47-297 |
1.10e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.48 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 47 DDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQGLGwPPCGKVLR 126
Cdd:cd17333 31 ADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGIL-DTGANTFV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 127 KWFEPSQFGTWWAILSTSMNLAGGLGP-IVAALMALSYDWRTTLSISGFICMGTSFVCLVLIKNEPSDVGLPNIEPGTtk 205
Cdd:cd17333 110 GALFEESSATRLNVLHGFFGLGALIGPlIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGA-- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 206 gkkglsgDHSTLAELLLSPYLWVLSSGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSD 285
Cdd:cd17333 188 -------FSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR 260
|
250
....*....|..
gi 946652444 286 RAVARVGLSLYG 297
Cdd:cd17333 261 RIKPHTLLVLSG 272
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
26-208 |
7.96e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.07 E-value: 7.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 26 FNRKTFSFVMPAIM----EEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVT 101
Cdd:cd17329 10 LNRLGFFMVWPFMAiylhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 102 VFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMA-LSYDWRTTLSISGFICmgtS 180
Cdd:cd17329 90 LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLlYSFRLLFLAAAVLFLL---A 166
|
170 180
....*....|....*....|....*...
gi 946652444 181 FVCLVLIKNEPSDVGLPNIEPGTTKGKK 208
Cdd:cd17329 167 ALVLLFLLPETRPKRRAAEKTEILRGYK 194
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
49-186 |
9.23e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 50.69 E-value: 9.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 49 LGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKW 128
Cdd:cd06173 246 YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLR 325
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 946652444 129 FEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLVL 186
Cdd:cd06173 326 VPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
30-435 |
1.26e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 50.30 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 30 TFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARW-------LFSSGLLLVGIVNvvfswsSTVTV 102
Cdd:cd17353 21 AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKailiggiLFGLGFILSAFAI------SLPLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 103 FSGLWFLNGLAQGLGWPPCGKVLRKWFePSQFGtwwaiLSTSMNLAG-GLG-----PIVAALMAlSYDWRTTLSISGFIC 176
Cdd:cd17353 95 FLGYGVLGGIGAGIGYITPVSTAVKWF-PDKRG-----LATGIVIAGfGLGslifsPLIAYLIN-TVGVPTTFLILGIIF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 177 MGTSFVCLVLIKNEPSDVGLPNIEPGTTKGKKGLSgdHSTLAELLLSPYLWVLssgYLVVFgvktCCTDWGQL------- 249
Cdd:cd17353 168 LIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPR--DYTPREMLRTPTFWLL---WLMFF----LNATAGLMligqakp 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 250 FLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRavarvglslYGNPRHVLLLSMMAGMSvsmylfrvtitsdspke 329
Cdd:cd17353 239 IGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDK---------IGRKNTLSIAFLIQGVA----------------- 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 330 nnfwivalhpLAALTGFTEQELWILILGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLAGLPFSTI 409
Cdd:cd17353 293 ----------MFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYV 362
|
410 420
....*....|....*....|....*.
gi 946652444 410 AKHYSWATAFWVAeitCAISTVAFFL 435
Cdd:cd17353 363 LYTGGYNAAFIIA---AALSLVALAL 385
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
14-436 |
2.08e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.54 E-value: 2.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 14 FTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWL-----FSSGLLLVG 88
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 89 IVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTT 168
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 169 LSISGfICMGTSFVCLVLIKNEPSDVGLPNIEPGTTKGKKGLS---GDHSTLAELLLSPYLWVLSSGYLVVFgvktcctd 245
Cdd:cd06173 161 FAINA-LSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRylrRSPLLRLLLLALALFALLGGALTVLL-------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 246 wgqLFLIQERGQSALVGSSYMSALE-IGGLVGSIAAGYLSDRavarvglslygNPRHVLLLSMMAGMSVSMYLFRVTits 324
Cdd:cd06173 232 ---PLLAKEVLGGGAAGYGLLLAAFgVGALLGALLLGRLSKR-----------RRRGRLLLIGALLLGLALLVLGLS--- 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 325 dspkeNNFWIVAlhplaaltgfteqeLWILILGAIFGFSsygpIALFGVIANESAPSNLCGTSHAIVALMANVGGFLAGL 404
Cdd:cd06173 295 -----PSLWLLL--------------AALFLLGLAGGLF----NVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGAL 351
|
410 420 430
....*....|....*....|....*....|..
gi 946652444 405 PFSTIAKHYSWATAFWVAEITCAISTVAFFLL 436
Cdd:cd06173 352 LAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
32-311 |
5.12e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 48.35 E-value: 5.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 32 SFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNG 111
Cdd:cd17365 19 GFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 112 LAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLsisgFICMGTSFVCLVLIKnep 191
Cdd:cd17365 99 LGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVF----LLGGVPPLILLPLLR--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 192 sdvglpniepgttkgkkglsgdhSTLAelllspyLWVLS-SGYLVVFGVKTcctdWGQLfLIQERGQSALVGSSYMSALE 270
Cdd:cd17365 172 -----------------------GTLL-------LWVTFfMGLLLVYLLNS----WLPK-LMVEAGYSLSQALTITLLLN 216
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 946652444 271 IGGLVGSIAAGYLSDRavarvglslyGNPRHVLLLSMMAGM 311
Cdd:cd17365 217 IGGVIGSLLLGWLADR----------FGPKRVLALFFALGA 247
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
17-188 |
3.21e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 46.01 E-value: 3.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 17 MFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSW 96
Cdd:cd17380 4 LFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 97 --SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGF 174
Cdd:cd17380 84 laYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGL 163
|
170
....*....|....
gi 946652444 175 ICMGTSFVCLVLIK 188
Cdd:cd17380 164 LGLLWALVWLIYLP 177
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
12-286 |
6.21e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 44.93 E-value: 6.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 12 VIFTAMFVGYTLYYFNRKTFS--FVMpAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGI 89
Cdd:cd17327 5 FILPLLCILYFLQYLDKSNISnaAVM-GMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 90 VNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTsmnlAGGLGPIVAALMALS------- 162
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYA----AAGLGSIFGGLLAYGvfkilgv 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 163 ---YDWRTTLSISGFICMGTSFVCLVLIKNEPSDVGLPNIE---------PGTTKGKKGLSGDHSTLAELLLSPYLWVLS 230
Cdd:cd17327 160 gglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEekelaverlRANQTGKGDQKFKWKQIKEAFKDPRTWLLF 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 946652444 231 SGYLVVFGVKTCCTdwGQLFLIQERGQSALVGSSYMS-ALEIGGLVGSIAAGYLSDR 286
Cdd:cd17327 240 LFFFCSQITNNGIS--NFLPLILKSLGFYSLQTNLLSvPIGALGAVSLLIAALLSDR 294
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
35-428 |
1.05e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 44.17 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 35 MPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQ 114
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 115 GLG---WPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGpivAALMALSYDWRTTLSISGFICMGTSfvcLVLIKNEP 191
Cdd:cd17393 102 GALdvaMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLG---AAAIGAGVSPGVHLLAAAVLLLLAA---LVAIRALL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 192 SDVGLPNIEPGTTKGKKGLsgdhstlaeLLLSPYLWVLssGYLVVFG--VKTCCTDWGQLFLIQERGQSALVGSSYMSAL 269
Cdd:cd17393 176 PGTGEAAEDRPDGAGKPGF---------LLPNRLLLLL--GLLALAAalAEGAAADWSALYLRDVLGASAALAALGYAVF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 270 EIGGLVGSIAAgylsDRAVARVGlslygnPRHVLLLSMM---AGMSVSmylfrvtitsdspkennfwIVALHPLAALTGF 346
Cdd:cd17393 245 SLAMTVGRLFG----DRLVDRFG------DVAVLRAGALlaaLGLLLA-------------------LLAPSVWVALAGF 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 347 TeqelwilILGaiFGFSSYGPIALfgvianeSAPSNLCGTSHAI-VALMANVG--GFLAGLP-FSTIAKHYSWATAFWVA 422
Cdd:cd17393 296 A-------LMG--LGLSVVVPLAF-------SAAGALPGLAAGIaVARVATLGylGFLVGPPlIGFLADATGLRTAFLVV 359
|
....*.
gi 946652444 423 EITCAI 428
Cdd:cd17393 360 ALLALL 365
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
14-160 |
2.24e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 43.33 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 14 FTAMFVGYTLYYFNRKTFSFVMPAIMEEI-ELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNV 92
Cdd:cd17503 180 FTLGLLLSFLLGLGLFGAMFLLPLYLQNVlGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 946652444 93 VFSW---SSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLG-PIVAALMA 160
Cdd:cd17503 260 LLAFltpDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGtALLATLLT 331
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
35-167 |
3.90e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.56 E-value: 3.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 35 MPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLF--SSGLLLVGIVNVVFSWSSTVTVFSGLwfLNGL 112
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFltALALFTLGSLLCGLAPNLASLIIFRI--LQGF 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 946652444 113 AQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRT 167
Cdd:cd17503 97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRW 151
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
13-186 |
4.33e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 42.15 E-value: 4.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 13 IFTAMFVGYTLYYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQ--MSARWLFSSGLLLVGIV 90
Cdd:cd17352 184 TFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLS 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 91 N--VVFSWSSTVTVFSGLWFlnGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLG-PIVAALMALSYDWRT 167
Cdd:cd17352 264 LlaFPLATTYVGLIVFSVLF--GFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGpPIAGLLRDYTGDYDA 341
|
170
....*....|....*....
gi 946652444 168 TLSISGFICMGTSFVCLVL 186
Cdd:cd17352 342 AFYFCGACLLLSGVLLFLL 360
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
50-186 |
8.30e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 8.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 50 GLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWF 129
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 946652444 130 EPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICMGTSFVCLVL 186
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV 170
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
47-176 |
1.63e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 40.88 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 47 DDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVtvfSGLW-----FLNGLAQGLGWPPC 121
Cdd:TIGR00894 76 ALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGG---GIALvvfcrVIQGLAQGSVSPAT 152
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 946652444 122 GKVLRKWFEPSQFGTWwailsTSMNLAG-GLGPIVAalmalsydwrttLSISGFIC 176
Cdd:TIGR00894 153 HKIIVKWAPPKERSRL-----LGMSTSGfQLGTFIF------------LPISGWLC 191
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
45-176 |
2.76e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.91 E-value: 2.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 45 DKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVN----VVFSWSSTVTVFsgLWFLNGLAQGLGWPP 120
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTlltpLAARGGYGALIV--LRILQGLAQGVTFPA 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 946652444 121 CGKVLRKWFEPSQFGTwwaiLSTSMNLAGGLGPIVaalmalsydwrtTLSISGFIC 176
Cdd:cd17318 132 MHALWAKWAPPLERSR----LTSIAYSGSQFGTVI------------AMPLSGFLC 171
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
16-192 |
3.42e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.53 E-value: 3.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 16 AMFVGYTLYYFNRKTFSFVMPAIMEEIeLDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFS 95
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADL-GPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 96 WSSTVTVFSGLWFLNGLA---QGLGWPPCGKVLrkwfEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYD--WRTTLS 170
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGagtQGLGAAVASELV----PNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFY 156
|
170 180
....*....|....*....|..
gi 946652444 171 ISGFICmGTSFVCLVLIKNEPS 192
Cdd:cd06179 157 INAIFN-ALALILLFFFYHPPP 177
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
34-286 |
3.71e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.46 E-value: 3.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 34 VMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLA 113
Cdd:cd17477 18 LLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 114 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMAlSYDWRTTLSISGFICMGTSFVCLVLIKNepsd 193
Cdd:cd17477 98 LAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGALPFLIAAVLLLLALVPLLLTRRAA---- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 194 vglPNIEPGTtkgkkglSGDHSTLAELLLSPYLWVLSSGYLVvfgvkTCCTDWGQLFLIQErGQSALVGSSYMSALEIGG 273
Cdd:cd17477 173 ---PEIEEAE-------SISLRRLLRIAPLALLGAFVAGFLE-----GAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGG 236
|
250
....*....|...
gi 946652444 274 LVGSIAAGYLSDR 286
Cdd:cd17477 237 LLLQWPLGWLADR 249
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
11-187 |
4.07e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 39.10 E-value: 4.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 11 TVIFTAMFVgytlyYFNRKTFSFVMPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIV 90
Cdd:cd17323 3 IISFLTFVV-----TFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 91 NVVFSWSSTVTVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTls 170
Cdd:cd17323 78 QIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWI-- 155
|
170
....*....|....*..
gi 946652444 171 isGFICMGTSFVCLVLI 187
Cdd:cd17323 156 --FWFLAIISGFCLILI 170
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
35-437 |
7.60e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.31 E-value: 7.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 35 MPAIMEEIELDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGIVNVVFSWSSTVTVFSGLWFLNGLAQ 114
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 115 GLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICmgtsFVCLVLIKNepsdv 194
Cdd:cd17321 99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG----LVALLLART----- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 195 glpniepgttkgkkgLSGdhSTLAELLLSpylwVLSSGYLVVFgvktcctdwgQLFLIQERGQSALVGSSYMSALEIGGL 274
Cdd:cd17321 170 ---------------FSG--AVLAAFLLG----AALGGLLFLL----------PLYLQGVLGYSPLQAGLALLPLALAML 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 275 VGSIAAGYLSDR--------------AVARVGLSLYGNPRHVLLLS-----MMAGMSVSMYLFRVTITSDSPKENnfwiv 335
Cdd:cd17321 219 VAAPLAGRLADRfgprlvlvagllltAVGLLLLALLGADSSVWLLLpglvlLGLGLGLFATPLTNAALSSVPKEK----- 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946652444 336 aLHPLAALTGFTEQelwiliLGAIFGfssygpIALFGVIANESAPSNLcGTSHAIVALMANVGGFLAGLpfstiakhysw 415
Cdd:cd17321 294 -AGAASGILNTARQ------LGGALG------VALLGALLTAGLSANL-GDSGVAALLSAAAAAFAAGF----------- 348
|
410 420
....*....|....*....|..
gi 946652444 416 ATAFWVAEITCAISTVAFFLLR 437
Cdd:cd17321 349 HLAFLVAAALALLAALLALLLP 370
|
|
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