|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
64-1014 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1010.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 64 YRDSVLLPKTEFPMKLtgqKLLDRELQIQ---QEcgfADLYSWQRE-RKAKNKFCLHDGPPYANGDPHVGHALNKILKDI 139
Cdd:COG0060 1 YKETLNLPKTDFPMRA---NLPKREPEILkfwEE---NDIYEKSREaRAGRPKFVLHDGPPYANGDIHIGHALNKILKDI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 140 RNRFEMLRGRQVHYIPGWDCHGLPIELKALGDLGTSG-----LSPLQIRQKAREFAEGAIARQKAAFQRWGVMADWDQCY 214
Cdd:COG0060 75 IVRYKTMRGFDVPYVPGWDCHGLPIELKVEKELGIKKkdiekVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 215 YTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAELEYnPEHVSRAIYATFPLVTLPPKiasqEGMESVS 294
Cdd:COG0060 155 LTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEY-KDVTSPSIYVKFPVKDEKAL----LLLEDAY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 295 VLVWTTQPWTIPANQAVCYMPNAQYSVVkRADNSEKFLVATERTASIAALLG-TDLQTVGTFTGSLLEGGICKHP----T 369
Cdd:COG0060 230 LVIWTTTPWTLPANLAVAVHPDIDYVLV-EVTGGERLILAEALVEAVLKELGiEDYEVLATFKGAELEGLRYEHPfyyvV 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 370 IPDKQVPLLPANHVTMVKGTGLVHTAPAHGMEDYSVASQFKLPVECMVDEDGTFNELAgPELQKLSVMtEGNDKVISMLK 449
Cdd:COG0060 309 GYDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEA-PLFAGLFVK-DANPAIIEDLK 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 450 QCNALLKEEQCVHSYPYDWRTKQPVVIRPSKQWFINTESLKDKAKEALQKVRVLPESARSSLLTMLDRRTYWCISRQRSW 529
Cdd:COG0060 387 ERGALLAREKITHSYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEWGEGRFGNMLENRPDWCISRQRYW 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 530 GVPIPVFYHKESGEALINKYTVSHIAQLFKEKGSDCWWELPIETLLPPEVLKKSKAGaaSDYVRGEDVLDIWFDSGASWA 609
Cdd:COG0060 467 GVPIPIWVCEDCGELHRTEEVIGSVAELLEEEGADAWFELDLHRPFLDETLKCPKCG--GTMRRVPDVLDVWFDSGSMHF 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 610 AVLEAESDSR--ADIYVEGKDQIGGWFQqSSLLTSVAVRNKAPYKSLVVHGFAVSEKGEKMSKSVGNVVDPDVVINggkd 687
Cdd:COG0060 545 AVLENREELHfpADFYLEGSDQTRGWFY-SSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVID---- 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 688 ptepAYGADVLRWWVAESNVFSEVQIGPSALSSARDSISKLRNTLKFLLGNLQGFDPRLQAVDPKQMHYIDQYMLHLLRE 767
Cdd:COG0060 620 ----KYGADILRLWVASSDYWGDLRFSDEILKEVRDVYRRLRNTYRFLLANLDDFDPAEDAVPYEDLPELDRWILSRLNE 695
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 768 YSIKVTDAYSEFDAGRVIRVLQAFITRELSSFYFSIIKDRLYCDAEDSLGRRSCQTVLEEILDGVTRSIAPILPHMAEEV 847
Cdd:COG0060 696 LIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEI 775
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 848 YLHAPGhDKEETLFKSGWIKSSSVWRRPGLEEAVEGACAIRDSFLSSIpgkNAARYD---------LTVAIEPGLLFELM 918
Cdd:COG0060 776 WQNLPG-EAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLKAL---EAARKEklirqpleaAVVLYADEELAAAL 851
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 919 ESLQEEptsttsqLAELMMAARVNLATkmprdlDPEALLNHGTFLINLEGGVIreesaySIAVTPTSAARCLRCRRY--- 995
Cdd:COG0060 852 ESLGDL-------LAEELNVSEVELVD------DAEDLGKDALKALDVEGISV------TVEVEKADGEKCERCWHYevg 912
|
970 980
....*....|....*....|
gi 2062420168 996 -TANSADcLCPRCQSVVSQA 1014
Cdd:COG0060 913 wTPEHEG-LCRRCVRRVQGL 931
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
87-1015 |
0e+00 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 936.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 87 RELQIQQECGFADLYSWQRERKAKNKFCLHDGPPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIEL 166
Cdd:PLN02843 8 REPEIQKLWEENQVYKRVSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIEL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 167 KALGDLGT---SGLSPLQIRQKAREFAEGAIARQKAAFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYK 243
Cdd:PLN02843 88 KVLQSLDQearKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRK 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 244 PVFWSPSSGTALAEAELEYnPE-HVSRAIYATFPLVTLPPKIASQ--EGMESVSVLVWTTQPWTIPANQAVCYMPNAQYS 320
Cdd:PLN02843 168 PVHWSPSSRTALAEAELEY-PEgHVSKSIYVAFPVVSPSETSPEEleEFLPGLSLAIWTTTPWTMPANAAVAVNDKLQYS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 321 VVKRADNSE-----------------------KFLVATERTASIAALLGTDLQTVGTFTGSLLEGGICKHPTIPDKQVPL 377
Cdd:PLN02843 247 VVEVQSFSEdestsggnkkkrpgnvlkeqqklFLIVATDLVPALEAKWGVKLVVLKTFPGSDLEGCRYIHPLYNRESPVV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 378 LPANHVTMVKGTGLVHTAPAHGMEDYSVASQFKLPVECMVDEDGTFNELAGPeLQKLSVMTEGNDKVISMLKQCNALLKE 457
Cdd:PLN02843 327 IGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQ-FSGLSVLGEGNAAVVEALDEAGSLLME 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 458 EQCVHSYPYDWRTKQPVVIRPSKQWFINTESLKDKAKEALQKVRVLPESARSSLLTMLDRRTYWCISRQRSWGVPIPVFY 537
Cdd:PLN02843 406 EAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPAQGENRIRAMVSGRSDWCISRQRTWGVPIPVFY 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 538 HKESGEALINKYTVSHIAQLFKEKGSDCWWELPIETLLPPEVLKKskagaASDYVRGEDVLDIWFDSGASWAAVLEAESD 617
Cdd:PLN02843 486 HVETKEPLMNEETIAHVKSIVAQKGSDAWWYMDVEDLLPEKYRDK-----ASDYEKGTDTMDVWFDSGSSWAGVLGSREG 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 618 SR--ADIYVEGKDQIGGWFqQSSLLTSVAVRNKAPYKSLVVHGFAVSEKGEKMSKSVGNVVDPDVVINGGKD-PTEPAYG 694
Cdd:PLN02843 561 LSypADLYLEGSDQHRGWF-QSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEGGKNqKQEPAYG 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 695 ADVLRWWVAESNVFSEVQIGPSALSSARDSISKLRNTLKFLLGNLQGFDPrLQAVDPKQMHYIDQYMLHLLREYSIKVTD 774
Cdd:PLN02843 640 ADVLRLWVASVDYTGDVLIGPQILKQMSDIYRKLRGTLRYLLGNLHDWKP-DNAVPYEDLPSIDKYALFQLENVVNEIEE 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 775 AYSEFDAGRVIRVLQAFITRELSSFYFSIIKDRLYCDAEDSLGRRSCQTVLEEILDGVTRSIAPILPHMAEEVYLHAPGH 854
Cdd:PLN02843 719 SYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQ 798
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 855 DK---EETLFKSGWIKSSSVWRRPGLEEAvegacairdSFLSSIpgkNAARYDLTVAIEP-------GLLFE-------- 916
Cdd:PLN02843 799 EDgsaAESVFEAGWPTPNEEWLSFPAEDV---------DFWSLL---LEVRDEVNKVLESarngkliGASLEakvylhas 866
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 917 ---LMESLQEEPTST--TSQLAELMMAARVNLATkmprDLDPEALLNHGTFLINLEGGvireeSAYSIAVTPTSAARCLR 991
Cdd:PLN02843 867 dasLAARLAELCGASngADELRRIFITSQVEVVS----SEDDETAACGSYTGEYVEGA-----GRVWVGVSRADGSKCER 937
|
970 980 990
....*....|....*....|....*....|
gi 2062420168 992 CRRYT------ANSADcLCPRCQSVVSQAH 1015
Cdd:PLN02843 938 CWNYSpavgsfSDHPT-LCERCYPVVIAQP 966
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
74-905 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 842.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 74 EFPMKLtgqKLLDRELQIQQECGFADLYS-WQRERKAKNKFCLHDGPPYANGDPHVGHALNKILKDIRNRFEMLRGRQVH 152
Cdd:TIGR00392 1 KFPMRG---NLSKREEKILAFWQENDIFEkVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 153 YIPGWDCHGLPIELKALGDLGTSG---LSPL---QIRQKAREFAEGAIARQKAAFQRWGVMADWDQCYYTFDGTYEAAQL 226
Cdd:TIGR00392 78 RKPGWDTHGLPIEHKVEKKLGISGkkeISSLeieEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 227 KVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAELEYN---PEHVSRAIYATFPLVTlppKIASQEGMESVSVLVWTTQPW 303
Cdd:TIGR00392 158 WLFKEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKenyKDVKDPSIYVKFPVKK---DKKTYLKVKLSSLLIWTTTPW 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 304 TIPANQAVCYMPNAQYSVVKRADNSEKFLVATERTASIAALLGTDLQTVGTFTGSLLEGGICKHPtIPDKQVPLLP---- 379
Cdd:TIGR00392 235 TLPSNLAIAVHPDFEYALVQDNTKVEYFILAKKLVEKLYNKAGSDYEIIKTFKGSDLEGLEYEHP-LYDFVSQLKEgapv 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 380 ---ANHVTMVKGTGLVHTAPAHGMEDYSVASQFKLPVECMVDEDGTFNELAGPElQKLSVMTEG------NDKVISMLKQ 450
Cdd:TIGR00392 314 vigGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDF-QGRFVKDADkdiikaNKIIIEQLKD 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 451 CNALLKEEQCVHSYPYDWRTKQPVVIRPSKQWFINTESLKDKAKEALQKVRVLPESARSSLLTMLDRRTYWCISRQRSWG 530
Cdd:TIGR00392 393 KGLLLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWGEGRFGNWLENRPDWCISRQRYWG 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 531 VPIPVFYHKESGEaLINKYTVSHIAQLFKEKGSDCWWELPIETLLPPEVLKKSKAGaasDYVRGEDVLDIWFDSGASWAA 610
Cdd:TIGR00392 473 IPIPIWYCEDTGE-PIVVGSIEELIELIELKGIDAWFEDLHRDFLDKITLKSGDGG---EYRRVPDVLDVWFDSGSMPYA 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 611 VLEAESDSR-------ADIYVEGKDQIGGWFqQSSLLTSVAVRNKAPYKSLVVHGFAVSEKGEKMSKSVGNVVDPDVVIN 683
Cdd:TIGR00392 549 SIHYPFENEkfkevfpADFILEGSDQTRGWF-YSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVIN 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 684 ggkdptepAYGADVLRWWVAESNVFSEVQIGPSALSSARDSISKLR-NTLKFLL--GNLQGFDPRLQAVDPKQMHYIDQY 760
Cdd:TIGR00392 628 --------KYGADILRLYVASSDPWEDLRFSDEILKQVVEKYRKIRwNTYRFLLtyANLDKFDPLFNSVAVEKFPEEDRW 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 761 MLHLLREYSIKVTDAYSEFDAGRVIRVLQAFITRELSSFYFSIIKDRLYCDAEDSLgRRSCQTVLEEILDGVTRSIAPIL 840
Cdd:TIGR00392 700 ILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEELSNWYIRIIRDRLYCEAKDND-KRAAQTTLYYALLTLVRLLAPFL 778
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2062420168 841 PHMAEEVYLHAPGHDKEETLFKSGWIKSSSVWRRPGLEEAVEGACAIRDSFLSsipGKNAARYDL 905
Cdd:TIGR00392 779 PHTAEEIYQNLPGGEEEESVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLA---LRDAANKKL 840
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
98-713 |
1.11e-177 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 530.45 E-value: 1.11e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 98 ADLYSWQRE-RKAKNKFCLHDGPPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKALGDLGTSG 176
Cdd:pfam00133 9 QGYFKPELEkRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEKKLGIKE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 177 ------LSPLQIRQKAREFAEGAIARQKAAFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPS 250
Cdd:pfam00133 89 kktrhkYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKLVNWSPA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 251 SGTALAEAELEYNpEHVSRAIYATFPLvtlppkiasqEGMESVSVLVWTTQPWTIPANQAVCYMPNAQYSVvkradNSEK 330
Cdd:pfam00133 169 LNTALSNLEVEYK-DVKGPSIHVAFPL----------ADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI-----TGEG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 331 FLVATERTASIAALlGTDLQTVGTFTGSLLEGGICKHPtIPDKQVPLLPANHVTMVKGTGLVHTAPAHGMEDYSVASQFK 410
Cdd:pfam00133 233 YILAEALLKSLYKK-GTDKKILEDFRGKELEGKEAIHP-FVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 411 LPVECMVDEDGTFNELAgPELQKLSVMtEGNDKVISMLKQCNALLKEEQCVHSYPYDWRTKQPVVIRPSKQWFINTESLK 490
Cdd:pfam00133 311 LEVINPVDDDGTFTEEA-PDFQGVYRF-DARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELA 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 491 DKAKEALQKVRVLPESARSSLLTMLDRRTYWCISRQRSWGVPIPVFYHKESGEALINKYTVSHIAQLFKEKGSDCWWELP 570
Cdd:pfam00133 389 DQALEAVEKVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRFEEEGSIKWLHRE 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 571 IETLLppevlkKSKAGaasDYVRGEDVLDIWFDSGASWAAVLEAESDSR--------ADIYVEGKDQIGGWFqQSSLLTS 642
Cdd:pfam00133 469 AKDKL------GYGKG---TLEQDEDVLDTWFSSGSWPFSTLGWPFVNTeefkkffpADMLLEGSDQTRGWF-YRMIMLS 538
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2062420168 643 VAVRNKAPYKSLVVHGFAVSEKGEKMSKSVGNVVDPDVVINggkdptepAYGADVLRWWVAESNVFSEVQI 713
Cdd:pfam00133 539 TALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID--------KYGADALRLWLANSDYGRDINL 601
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
108-865 |
8.11e-116 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 377.09 E-value: 8.11e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 108 KAKNKFCLHDGPPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLP----------IELKALGDLGTSgl 177
Cdd:TIGR00422 30 SNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIAtqvkvekklgAEGKTKHDLGRE-- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 178 splQIRQKAREFAEGAIARQKAAFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPSSGTALAE 257
Cdd:TIGR00422 108 ---EFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISD 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 258 AELEYNPehVSRAI-YATFPLvtlppkiasqEGMESVSVLVWTTQPWTIPANQAVCYMPNaqysvvkradnsekflvaTE 336
Cdd:TIGR00422 185 IEVEYKE--VKGKLyYIRYPL----------ANGSKDYLVVATTRPETMFGDTAVAVHPE------------------DE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 337 RTASiaallgtdlqtvgtftgslLEGGICKHPTIPdKQVPLLPANHVTMVKGTGLVHTAPAHGMEDYSVASQFKLPVECM 416
Cdd:TIGR00422 235 RYKH-------------------LIGKKVILPLTG-RKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINI 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 417 VDEDGTFNELAGpELQKLSVMtEGNDKVISMLKQCNALLKEEQCVHSYPYDWRTKQPVVIRPSKQWFINTESLKDKAKEA 496
Cdd:TIGR00422 295 LDEDGLLNENAG-KYQGLTRF-EARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEA 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 497 LQ--KVRVLPESARSSLLTMLDRRTYWCISRQRSWGVPIPVFYHKESGEALINKYTvshiaqlfkekgsdcwwelpietl 574
Cdd:TIGR00422 373 AEegEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGEVYVAKEE------------------------ 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 575 lpPEVLKKSKAGAASDYVRGEDVLDIWFDSGASWAAVLEAESDSR-------ADIYVEGKDQIGGWFQQsSLLTSVAVRN 647
Cdd:TIGR00422 429 --PLPDDKTNTGPSVELEQDTDVLDTWFSSSLWPFSTLGWPDETKdlkkfypTDLLVTGYDIIFFWVAR-MIFRSLALTG 505
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 648 KAPYKSLVVHGFAVSEKGEKMSKSVGNVVDPDVVINggkdptepAYGADVLRWWVAESNVF-SEVQIGPSALSSARDSIS 726
Cdd:TIGR00422 506 QVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIE--------KYGADALRFTLASLVTPgDDINFDWKRVESARNFLN 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 727 KLRNTLKFLLGNLQGFDPRLQAVDPKQMhyIDQYMLHLLREYSIKVTDAYSEFDAGRVIRVLQAFITRELSSFYFSIIKD 806
Cdd:TIGR00422 578 KLWNASRFVLMNLSDDLELSGGEEKLSL--ADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCDWYIELVKY 655
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*....
gi 2062420168 807 RLYCDAEDSlgRRSCQTVLEEILDGVTRSIAPILPHMAEEVYLHApgHDKEETLFKSGW 865
Cdd:TIGR00422 656 RLYNGNEAE--KKAARDTLYYVLDKALRLLHPFMPFITEEIWQHF--KEGADSIMLQSY 710
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
119-887 |
5.50e-110 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 359.51 E-value: 5.50e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 119 PPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKALGDLGT--SGLSPLQIRQKAREFAEGAIAR 196
Cdd:PRK13208 46 PPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDDNGLPTERKVEKYYGIrkDDISREEFIELCRELTDEDEKK 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 197 QKAAFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAELEYNPEHvSRAIYATFP 276
Cdd:PRK13208 126 FRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYRERE-GKLNYIKFP 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 277 LVTLPPkiasqegmesvsVLVWTTQPWTIPANQAVCYMPNaqysvvkraDnsekflvatERTASiaaLLGtdlqtvgtft 356
Cdd:PRK13208 205 VEDGEE------------IEIATTRPELLPACVAVVVHPD---------D---------ERYKH---LVG---------- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 357 gslleggicKHPTIP--DKQVPLLPANHVTMVKGTGLVhtapahgM-------EDYSVASQFKLPVECMVDEDGTFNELA 427
Cdd:PRK13208 242 ---------KTAIVPlfGVEVPILADPLVDPDFGTGAV-------MictfgdkTDVTWWRELNLPTRIIIDEDGRMTEAA 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 428 GpELQKLSVmTEGNDKVISMLKQCNALLKEEQCVHSYPYDWRTKQPVVIRPSKQWFINTESLKDKAKEALQKVRVLPESA 507
Cdd:PRK13208 306 G-KLAGLTI-EEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHM 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 508 RSSLL----TM-LDrrtyWCISRQRSWGVPIPVFYHKESGEALinkytvshiaqLFKEKgsdcwwELPIE-TLLPPEVLK 581
Cdd:PRK13208 384 RVRLEnwieGLnWD----WCISRQRYFGTPIPVWYCKDCGHPI-----------LPDEE------DLPVDpTKDEPPGYK 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 582 KSKAGaaSDYVRGE-DVLDIWFDSGASWAAVLEAESDSR-------ADIYVEGKDQIGGW-FqqSSLLTSVAVRNKAPYK 652
Cdd:PRK13208 443 CPQCG--SPGFEGEtDVMDTWATSSITPLIVTGWERDEDlfekvfpMDLRPQGHDIIRTWlF--YTILRAYLLTGKLPWK 518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 653 SLVVHGFAVSEKGEKMSKSVGNVVDPDVVINggkdptepAYGADVLRWWVAESN-----VFSEVQIGpsalsSARDSISK 727
Cdd:PRK13208 519 NIMISGMVLDPDGKKMSKSKGNVVTPEELLE--------KYGADAVRYWAASARlgsdtPFDEKQVK-----IGRRLLTK 585
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 728 LRNTLKFLLgnlqGFDPRLQAVDPKQMHYIDQYMLHLLREYSIKVTDAYSEFDAGRVIRVLQAFITRELSSFYFSIIKDR 807
Cdd:PRK13208 586 LWNASRFVL----HFSADPEPDKAEVLEPLDRWILAKLAKVVEKATEALENYDFAKALEEIESFFWHVFCDDYLELVKSR 661
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 808 LYcDAEDSLGRRSCQTVLEEILDGVTRSIAPILPHMAEEVY--LHAPGHDKEEtlfksgWIKSSSVWRRPGLEEAVEGAC 885
Cdd:PRK13208 662 AY-GEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWswLYGGSVHRAS------WPEPDEELIDEEDEELGELAK 734
|
..
gi 2062420168 886 AI 887
Cdd:PRK13208 735 EI 736
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
112-710 |
6.39e-105 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 330.73 E-value: 6.39e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 112 KFCLHDGPPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKALGDLGTSG------LSPLQIRQK 185
Cdd:cd00818 2 EFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGkkdiekMGIAEFNAK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 186 AREFaegaiarqkaafqrwgVMadwdqcyytfdgTYEAAQLKVFQEMhskgliyqdykpvfwspssgtalaeaeleynpe 265
Cdd:cd00818 82 CREF----------------AL------------RYVDEQEEQFQRL--------------------------------- 100
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 266 hvsrAIYATF--PLVTLPPKIasqegMESVsvlvWttqpWTipanqavcympnaqysvvkradnsekFLVATERtasiaa 343
Cdd:cd00818 101 ----GVWVDWenPYKTMDPEY-----MESV----W----WV--------------------------FKQLHEK------ 131
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 344 llgtdlqtvgtftgslleggickhptipdkqvpllpanhvtmvkgtGLVHtapahgmEDYsvasqfklpvecmvdedgtf 423
Cdd:cd00818 132 ----------------------------------------------GLLY-------RGY-------------------- 138
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 424 nelagpelqklsvmtegndKVIsmlkqcnallkeeqcvhsyPYdwrtkqPVVIRPSKQWFINTESLKDKAKEALQKVRVL 503
Cdd:cd00818 139 -------------------KVV-------------------PW------PLIYRATPQWFIRVTKIKDRLLEANDKVNWI 174
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 504 PESARSSLLTMLDRRTYWCISRQRSWGVPIPVFYHKESGEALInkytvshiaqlfkekgsdcwwelpietllppevlkks 583
Cdd:cd00818 175 PEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV------------------------------------- 217
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 584 kagaasdyVRGEDVLDIWFDSGASWAAVL-------EAESDSRADIYVEGKDQIGGWFqQSSLLTSVAVRNKAPYKSLVV 656
Cdd:cd00818 218 --------RRVPDVLDVWFDSGSMPYAQLhypfeneDFEELFPADFILEGSDQTRGWF-YSLLLLSTALFGKAPYKNVIV 288
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 2062420168 657 HGFAVSEKGEKMSKSVGNVVDPDVVInggkdptePAYGADVLRWWVAESNVFSE 710
Cdd:cd00818 289 HGFVLDEDGRKMSKSLGNYVDPQEVV--------DKYGADALRLWVASSDVYAE 334
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
104-850 |
7.29e-81 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 286.24 E-value: 7.29e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 104 QRER-KAKNKFCLHDGPPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIEL---KALGDLGTSGLSP 179
Cdd:PLN02882 30 QLKRtEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEYeidKKLGIKRRDDVLK 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 180 LQIrQKAREFAEGAIARQKAAFQ----RWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPSSGTAL 255
Cdd:PLN02882 110 MGI-DKYNEECRSIVTRYSKEWEktvtRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 256 AEAELEYNPEHVSR-AIYATFPLVTLPpkiasqegmESVSVLVWTTQPWTIPANQAVCYMPNAQYSVVKRADNSEKFLVA 334
Cdd:PLN02882 189 SNFEAGLNYKDVSDpAVMVSFPIVGDP---------DNASFVAWTTTPWTLPSNLALCVNPNFTYVKVRNKYTGKVYIVA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 335 TERtasIAALLGTDLQTVGTFTGSLLEGGICKHPTIPDKQV------PLLP--------------ANHVTMVKGTGLVHT 394
Cdd:PLN02882 260 ESR---LSALPTAKPKSKKGSKPENAAEGYEVLAKVPGSSLvgkkyePLFDyfsefsdtafrvvaDDYVTDDSGTGVVHC 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 395 APAHGMEDYSVASQFK-------LPveCMVDEDGTFNELAgPELQKLSVmTEGNDKVISMLKQCNALLKEEQCVHSYPYD 467
Cdd:PLN02882 337 APAFGEDDYRVCLANGiiekggnLP--VPVDDDGCFTEKV-TDFSGRYV-KDADKDIIAAIKAKGRLVKSGSITHSYPFC 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 468 WRTKQPVVIRPSKQWFINTESLKDKAKEALQKVRVLP------------ESARSslltmldrrtyWCISRQRSWGVPIPV 535
Cdd:PLN02882 413 WRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPdyvkekrfhnwlENARD-----------WAVSRSRFWGTPLPI 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 536 fYHKESGEALINKYTVSHIAQLFKEKGSDCWWE----LPIETLLPPE--VLKkskagaasdyvRGEDVLDIWFDSGASWA 609
Cdd:PLN02882 482 -WISDDGEEVVVIGSIAELEKLSGVKVTDLHRHfidhITIPSSRGPEfgVLR-----------RVDDVFDCWFESGSMPY 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 610 AVLEA--------ESDSRADIYVEGKDQIGGWFQQSSLLtSVAVRNKAPYKSLVVHGFAVSEKGEKMSKSVGNVVDPDVV 681
Cdd:PLN02882 550 AYIHYpfenkelfEKNFPADFVAEGLDQTRGWFYTLMVL-STALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEV 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 682 INggkdptepAYGADVLRWWV-------AESNVFSEVQIgpsaLSSARDSISKLRNTLKFLLGN--------LQGFDPRL 746
Cdd:PLN02882 629 ID--------KYGADALRLYLinspvvrAEPLRFKEEGV----FGVVKDVFLPWYNAYRFLVQNakrlevegGAPFVPLD 696
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 747 QAVDPKQMHYIDQYMLHLLREYsikVTDAYSEFDAGR---VIRVLQAFITrELSSFYFSIIKDRL--YCDAEDSlgrRSC 821
Cdd:PLN02882 697 LAKLQNSANVLDRWINSATQSL---VKFVREEMGAYRlytVVPYLVKFID-NLTNIYVRFNRKRLkgRTGEEDC---RTA 769
|
810 820
....*....|....*....|....*....
gi 2062420168 822 QTVLEEILDGVTRSIAPILPHMAEEVYLH 850
Cdd:PLN02882 770 LSTLYNVLLTSCKVMAPFTPFFTEVLYQN 798
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
713-892 |
2.05e-76 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 248.21 E-value: 2.05e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 713 IGPSALSSARDSISKLRNTLKFLLGNLQGFDPRLQAVDPKQMHYIDQYMLHLLREYSIKVTDAYSEFDAGRVIRVLQAFI 792
Cdd:cd07960 1 ISDEILKQVAEAYRKIRNTFRFLLGNLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 793 TRELSSFYFSIIKDRLYCDAEDSLGRRSCQTVLEEILDGVTRSIAPILPHMAEEVYLHAPGHDKEETLFKSGWIKSSSVW 872
Cdd:cd07960 81 TVDLSAFYLDIIKDRLYCDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKEESVFLEDWPELPEEW 160
|
170 180
....*....|....*....|
gi 2062420168 873 RRPGLEEAVEGACAIRDSFL 892
Cdd:cd07960 161 KDEELEEKWEKLLALRDEVN 180
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
127-882 |
4.59e-69 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 248.04 E-value: 4.59e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 127 HVGHALNKILKDIRNRFEMLRGRQVHYIPGWDcH-GlpI--------ELKALG----DLGtsglsplqiR----QKAREF 189
Cdd:COG0525 51 HMGHALNNTLQDILIRYKRMQGYNTLWQPGTD-HaG--IatqavverQLAEEGksrhDLG---------RekflERVWEW 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 190 AE---GAIARQkaaFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAELEYNPE- 265
Cdd:COG0525 119 KEesgGTITNQ---LRRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVk 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 266 ----HVSraiYatfPLVtlppkiasqEGMESVSVLvwTTQPWTIPANQAVCYMPNaqysvvkraDnsekflvatERTASI 341
Cdd:COG0525 196 ghlwHIR---Y---PLA---------DGSGYIVVA--TTRPETMLGDTAVAVHPE---------D---------ERYKHL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 342 aallgtdlqtVGTFtgslleggiCKHPtIPDKQVPLLPANHVTMVKGTGLVHTAPAHGMEDYSVASQFKLPVECMVDEDG 421
Cdd:COG0525 241 ----------IGKT---------VILP-LVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 422 TFNELAGpELQKLSVMtEGNDKVISMLKQCNALLKEEQCVHSYPYDWRTKqpVVIRP--SKQWFINTESLKDKAKEALQ- 498
Cdd:COG0525 301 TINENAG-KYRGLDRF-EARKAIVADLEELGLLVKVEPHKHSVGHSDRSG--TVIEPylSDQWFVKMKPLAKPAIEAVEd 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 499 -KVRVLPESARsslltmldrRTY---------WCISRQRSWGVPIPVFYHKEsgealiNKYTVSHIAqlfkekgsdcwwe 568
Cdd:COG0525 377 gEIKFVPERWE---------KTYfhwmenirdWCISRQLWWGHRIPAWYCPD------GEVYVARTE------------- 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 569 lpietllpPEVLKKSKAGaasDYVRGEDVLDIWFdSGASWA-AVLeaesdsradiyvegkdqigGWFQQSSLL-----TS 642
Cdd:COG0525 429 --------PEACAKAGSV---NLTQDEDVLDTWF-SSALWPfSTL-------------------GWPEKTEDLkyfypTS 477
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 643 VAV--------------------RNKAPYKSLVVHGFAVSEKGEKMSKSVGNVVDPDVVINggkdptepAYGADVLRWWV 702
Cdd:COG0525 478 VLVtgfdiiffwvarmimmglhfTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLID--------KYGADALRFTL 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 703 AESNV------FSEvqigpSALSSARDSISKLRNTLKFLLGNLQGFDPRlQAVDPKQMHYIDQYMLHLLREYSIKVTDAY 776
Cdd:COG0525 550 AALASpgrdikFDE-----ERVEGYRNFANKLWNASRFVLMNLEGFDPG-LDPDPEELSLADRWILSRLNKTIAEVTEAL 623
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 777 SEFDAGRVIRVLQAFITRELSSFYFSIIKDRLYcdAEDSLGRRSCQTVLEEILDGVTRSIAPILPHMAEEVYLHAPGHDK 856
Cdd:COG0525 624 EKYRFDEAAQALYDFVWNEFCDWYLELAKPRLY--GGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKE 701
|
810 820
....*....|....*....|....*.
gi 2062420168 857 EETLFKSGWIKSSSVWRRPGLEEAVE 882
Cdd:COG0525 702 GESIMLAPWPEADEELIDEEAEAEFE 727
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
127-865 |
8.99e-68 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 244.24 E-value: 8.99e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 127 HVGHALNKILKDIRNRFEMLRGRQVHYIPGWDcH-GlpI--------ELKALG----DLGtsglsplqirqkaRE-FAE- 191
Cdd:PRK05729 52 HMGHALNNTLQDILIRYKRMQGYNTLWLPGTD-HaG--IatqmvverQLAAEGksrhDLG-------------REkFLEk 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 192 ---------GAIARQkaaFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAELEY 262
Cdd:PRK05729 116 vwewkeesgGTITNQ---LRRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEY 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 263 NPEHVSraiyatfpLVTLPPKIASQEGmesvSVLVWTTQPWTIPANQAVCYMPNaqysvvkraDnsekflvatERTASIa 342
Cdd:PRK05729 193 KEVKGK--------LWHIRYPLADGSD----YLVVATTRPETMLGDTAVAVNPE---------D---------ERYKHL- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 343 allgtdlqtVGTFtgslleggiCKHPtIPDKQVPLLPANHVTMVKGTGLVHTAPAHGMEDYSVASQFKLP-VECMvDEDG 421
Cdd:PRK05729 242 ---------IGKT---------VILP-LVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPmINIM-DEDG 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 422 TFNELAGpELQKLSVMtEGNDKVISMLKQCNALLKEEQCVHSYPYDWRTKQPVVIRPSKQWFINTESLKDKAKEALQ--K 499
Cdd:PRK05729 302 TINENPG-EYQGLDRF-EARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVEngE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 500 VRVLPEsarsslltmldR--RTY---------WCISRQRSWGVPIPVFYHKEsgealiNKYTVSHIAqlfKEKGSDCWWE 568
Cdd:PRK05729 380 IKFVPE-----------RweKTYfhwmeniqdWCISRQLWWGHRIPAWYDED------GEVYVGREE---PEAREKALLT 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 569 lpietllppevlkkskagaasdyvRGEDVLDIWFDSGAsWA-AVLeaesdsradiyvegkdqigGWFQQSSLL-----TS 642
Cdd:PRK05729 440 ------------------------QDEDVLDTWFSSAL-WPfSTL-------------------GWPEKTEDLkrfypTS 475
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 643 VAV--------------------RNKAPYKSLVVHGFAVSEKGEKMSKSVGNVVDPDVVINggkdptepAYGADVLRWWV 702
Cdd:PRK05729 476 VLVtgfdiiffwvarmimmglhfTGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLID--------KYGADALRFTL 547
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 703 AESNV------FSEvqigpSALSSARDSISKLRNTLKFLLGNLQGFDPrLQAVDPKQMHYIDQYMLHLLREYSIKVTDAY 776
Cdd:PRK05729 548 AALASpgrdirFDE-----ERVEGYRNFANKLWNASRFVLMNLEGADV-GELPDPEELSLADRWILSRLNRTVAEVTEAL 621
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 777 SEFDAGRVIRVLQAFITRELSSFYFSIIKDRLYCDAedslgRRSCQTVLEEILDGVTRSIAPILPHMAEEVYLHAPGHDK 856
Cdd:PRK05729 622 DKYRFDEAARALYEFIWNEFCDWYLELAKPVLQEAA-----KRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGI 696
|
....*....
gi 2062420168 857 EETLFKSGW 865
Cdd:PRK05729 697 EESIMLAPW 705
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
108-848 |
1.29e-64 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 238.33 E-value: 1.29e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 108 KAKNKFCLHDGPPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIE--------LKALGDLGTSGLSP 179
Cdd:PTZ00427 99 KNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEyeiekennINKKEDILKMGIDV 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 180 LQirQKAREFAEGAIARQKAAFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAE 259
Cdd:PTZ00427 179 YN--EKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFE 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 260 LEYN----PEH---VSRAIYATFPLVT-----------LPPKIA------SQEGMESVS-------------VLVWTTQP 302
Cdd:PTZ00427 257 LNLNykdtPDPsiiISFVLCSDFPKVEeecnieedkqlLGEKYSvlynnkRENSNNGNNnstnnvcyaqhseILAWTTTP 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 303 WTIPANQAVCYMPNAQYSVVKRADNSEKFLVATERTASIAALLG---TDLQTVGTFTGSLLEGGICK--------HPTIP 371
Cdd:PTZ00427 337 WTLPSNLALCVNEHFTYLRIHHVKSNRVVIVGECRLEWIMKELKwnvEDLKIVNRFKGKELKGLRYKplftnfyeKYNFK 416
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 372 DKQVPLLPANHVTMVKGTGLVHTAPAHGMEDYSVASQFKL--PVECM----VDEDGTF-NELAgpELQKLSVmTEGNDKV 444
Cdd:PTZ00427 417 ERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidPEKNIfidpLDANGYFtNEVE--EVQNLYI-KEADNVI 493
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 445 ISMLKQCNALLKEEQCVHSYPYDWRTKQPVVIRPSKQWFINTESLKDKAKEALQKVRVLPESARSSLL-TMLDRRTYWCI 523
Cdd:PTZ00427 494 KKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYWIPAHIKEKKFhNWIKDAKDWCI 573
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 524 SRQRSWGVPIPVfYHKESGEALINKYTVSHIAQLFKEKGSDCWWELPIETLlppeVLKKSKAGAASDYVRGEDVLDIWFD 603
Cdd:PTZ00427 574 SRNRYWGTPIPI-WADEKMETVICVESIKHLEELSGVKNINDLHRHFIDHI----EIKNPKGKTYPKLKRIPEVFDCWFE 648
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 604 SGA-SWAAVLEAESDSR--------ADIYVEGKDQIGGWFqQSSLLTSVAVRNKAPYKSLVVHGFAVSEKGEKMSKSVGN 674
Cdd:PTZ00427 649 SGSmPYAKVHYPFSTEKedfhkifpADFIAEGLDQTRGWF-YTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKN 727
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 675 VVDPDVVINggkdptepAYGADVLRWWVAESnvfseVQIGPSALSSARDSISKLRNTlkFLLGNLQGFD------PRLQA 748
Cdd:PTZ00427 728 YPDPLYILD--------KYGADSLRLYLINS-----VAVRAENLKFQEKGVNEVVKS--FILPFYHSFRffsqevTRYEC 792
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 749 VDPKQMHYIDQYMLH--------LLREYSIKVTDAYSEFDAGRVIRVLQAFIT--RELSSFYFSIIKDRLycdaEDSLGR 818
Cdd:PTZ00427 793 LNKKQFLFNTDYIYKndnimdqwIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQfiENLTNWYIRLNRDRM----RGSLGE 868
|
810 820 830
....*....|....*....|....*....|...
gi 2062420168 819 RSCQ---TVLEEILDGVTRSIAPILPHMAEEVY 848
Cdd:PTZ00427 869 ENCLqslCTTYRTLHLFTVLMAPFTPFITEYIY 901
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
119-907 |
6.65e-62 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 229.11 E-value: 6.65e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 119 PPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPI------ELKALGDLGTSGLSPLQIRQKAREFAEG 192
Cdd:PRK14900 56 PPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATqmivekELKKTEKKSRHDLGREAFLERVWAWKEQ 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 193 AIARQKAAFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAELEYNPEHVSRAIY 272
Cdd:PRK14900 136 YGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQGELWS 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 273 ATFPLVTlppkiasqegmESVSVLVWTTQPWTIPANQAVCYMPNaqysvvkradnSEKFLvatertasiaALLGTDLqtv 352
Cdd:PRK14900 216 FAYPLAD-----------GSGEIVVATTRPETMLGDTAVAVHPL-----------DPRYM----------ALHGKKV--- 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 353 gtftgslleggicKHPtIPDKQVPLLP-ANHVTMVKGTGLVHTAPAHGMEDYSVASQFKLPVECMVDEDGTFNELAGPeL 431
Cdd:PRK14900 261 -------------RHP-ITGRTFPIVAdAILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEAGP-L 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 432 QKLSVMtEGNDKVISMLKQCNALLKEEQcvHSYPYDWRTKQPVVIRP--SKQWFINTESLKDKAKEALQ--KVRVLPESA 507
Cdd:PRK14900 326 AGLDRF-EARKEVKRLLAEQGLDRGAKP--HVLPLGRCQRSATILEPllSDQWYVRIEPLARPAIEAVEqgRTRFIPEQW 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 508 RSSLLTMLDRRTYWCISRQRSWGVPIPVFYHKEsGEALINKytvshiaqlfkEKGSDCwwelpietllppevlkkSKAGA 587
Cdd:PRK14900 403 TNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPD-GHVTVAR-----------ETPEAC-----------------STCGK 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 588 AsDYVRGEDVLDIWFDSGASWAAVL--EAESDSRADIYVE-----GKDQIGGWFQQSsLLTSVAVRNKAPYKSLVVHGFA 660
Cdd:PRK14900 454 A-ELRQDEDVLDTWFSSGLWPFSTMgwPEQTDTLRTFYPTsvmetGHDIIFFWVARM-MMMGLHFMGEVPFRTVYLHPMV 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 661 VSEKGEKMSKSVGNVVDPDVVInggkdptePAYGADVLRWWVAE-SNVFSEVQIGPSALSSARDSISKLRNTLKFLLGNL 739
Cdd:PRK14900 532 RDEKGQKMSKTKGNVIDPLVIT--------EQYGADALRFTLAAlTAQGRDIKLAKERIEGYRAFANKLWNASRFALMNL 603
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 740 QGFDprLQAVDPKQ--MHYIDQYMLHLLREYSIKVTDAYSEFDAGRVIRVLQAFITRELSSFYFSIIKDRLYcdAEDSLG 817
Cdd:PRK14900 604 SGYQ--ERGEDPARlaRTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELAKEALA--SEDPEA 679
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 818 RRSCQTVLEEILDGVTRSIAPILPHMAEEVYlhapgHDKEETLFKSGWIKSSSVWRRPGLEEAVEGACAIRDSFLSSIPG 897
Cdd:PRK14900 680 RRSVQAVLVHCLQTSYRLLHPFMPFITEELW-----HVLRAQVGASAWADSVLAAEYPRKGEADEAAEAAFRPVLGIIDA 754
|
810
....*....|
gi 2062420168 898 KNAARYDLTV 907
Cdd:PRK14900 755 VRNIRGEMGI 764
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
119-869 |
4.87e-59 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 219.81 E-value: 4.87e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 119 PPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKALGDLGTSG-----LSPLQIRQKAREFAE-- 191
Cdd:PLN02943 96 PPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVVEKMLASEGikrtdLGRDEFTKRVWEWKEky 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 192 -GAIARQkaaFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAELEYNpEHVSRA 270
Cdd:PLN02943 176 gGTITNQ---IKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYS-EEPGTL 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 271 IYATFPLVtlppkiasqeGMESVSVLVWTTQPWTIPANQAVCYMP-NAQYSvvkradnsekflvatertasiaallgtdl 349
Cdd:PLN02943 252 YYIKYRVA----------GGSEDFLTIATTRPETLFGDVAIAVNPeDDRYS----------------------------- 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 350 QTVGTFTGSLLEGGickhptipdKQVPLLPANHVTMVKGTGLVHTAPAHGMEDYSVASQFKLPVECMVDEDGTFNELAGp 429
Cdd:PLN02943 293 KYIGKMAIVPMTYG---------RHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVAG- 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 430 elqklSVMTEGNDKVISMLKQCNALLKEEQCVHSYPYDWRTKQpvVIRP--SKQWFINTESLKDKAKEALQK--VRVLPE 505
Cdd:PLN02943 363 -----LYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGE--VIEPlvSKQWFVTMEPLAEKALKAVENgeLTIIPE 435
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 506 SARSSLLTMLDRRTYWCISRQRSWGVPIPVFYhkESGEALINKYTVSHIAQlfkekgsdcwwelpietllppEVLKKS-- 583
Cdd:PLN02943 436 RFEKIYNHWLSNIKDWCISRQLWWGHRIPVWY--IVGKDCEEDYIVARSAE---------------------EALEKAre 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 584 KAGAASDYVRGEDVLDIWFDSGAsWAAVLEAESDSRADIYVE---------GKDQIGGWFQQsSLLTSVAVRNKAPYKSL 654
Cdd:PLN02943 493 KYGKDVEIYQDPDVLDTWFSSAL-WPFSTLGWPDVSAEDFKKfypttvletGHDILFFWVAR-MVMMGIEFTGTVPFSYV 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 655 VVHGFAVSEKGEKMSKSVGNVVDPdvvINGGKDptepaYGADVLRWWVAESNVFSEVQIGPSALSSARDSISKLRNTLKF 734
Cdd:PLN02943 571 YLHGLIRDSQGRKMSKTLGNVIDP---LDTIKE-----FGTDALRFTLALGTAGQDLNLSTERLTSNKAFTNKLWNAGKF 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 735 LLGNLQGfDPRLQAVDPKQMHYIDQ------------YMLHLLREYSIKVTDAYSEFDAGRVIRVLQAFITRELSSFYFS 802
Cdd:PLN02943 643 VLQNLPS-QSDTSAWEHILACKFDKeesllslplpecWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSDFADWYIE 721
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2062420168 803 IIKDRLYCDAEDSLGRRScQTVLEEILDGVTRSIAPILPHMAEEVYLHAPghDKEETLFKSGWIKSS 869
Cdd:PLN02943 722 ASKTRLYHSGDNSALSRA-QAVLLYVFENILKLLHPFMPFVTEELWQALP--YRKEALIVSPWPQTS 785
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
93-970 |
4.31e-57 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 214.10 E-value: 4.31e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 93 QECGFADLYSWQRERKAKNKFCLHDGPPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIEL---KAL 169
Cdd:PTZ00419 42 EKSGFFKPAEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIATQVvveKKL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 170 gdLGTSGLSPLQI-RQ----KAREFAE---GAIARQkaaFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQD 241
Cdd:PTZ00419 122 --MKEENKTRHDLgREeflkKVWEWKDkhgNNICNQ---LRRLGSSLDWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 242 YKPVFWSPSSGTALAEAELEYnpEHVSRAIYATFPL------VTLPPKIASQ-EGMESVSVLVWTTQPWTIPANQAVCYM 314
Cdd:PTZ00419 197 TRLVNWCCYLKTAISDIEVEF--EEIEKPTKITIPGydkkveVGVLWHFAYPlEDSGQEEIVVATTRIETMLGDVAVAVH 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 315 PNaqysvvkraDNSEKFLVatertasiaallgtdlqtvgtftgslleGGICKHPTIPDKQVPL-LPANHVTMVKGTGLVH 393
Cdd:PTZ00419 275 PK---------DERYKKLH----------------------------GKELIHPFIPDRKIPIiADDELVDMEFGTGAVK 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 394 TAPAHGMEDYSVASQFKLPVECMVDEDGTFNELAGPelqkLSVMT--EGNDKVISMLKQCNaLLKEeqcVHSYPYDW--- 468
Cdd:PTZ00419 318 ITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGE----FAGMHrfDCRRKIEEELKEMG-LLRD---KVPNPMRLprc 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 469 -RTKQPV--VIRPskQWFINTESLKDKAKEALQK--VRVLPESARSSLLTMLDRRTYWCISRQRSWGVPIPVfyhkesge 543
Cdd:PTZ00419 390 sRSGDIVepMLIP--QWYVNCKDMAKRAVEAVRNgeLKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPA-------- 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 544 alinkYTVSHIAQLFKEKGSDCW-----WElpietllppEVLKKSKA-----GAASDYVRGEDVLDIWFDSGASWAAVL- 612
Cdd:PTZ00419 460 -----YRVISKGPETDPSDEEPWvvarsEE---------EALEKAKKkfglsEEDFELEQDEDVLDTWFSSGLFPFSTLg 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 613 --EAESDSRA----DIYVEGKDQIGGWFQQsSLLTSVAVRNKAPYKSLVVHGFAVSEKGEKMSKSVGNVVDPDVVING-- 684
Cdd:PTZ00419 526 wpDQTDDLQRffptSLLETGSDILFFWVAR-MVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGis 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 685 ----------GKDPTE-----------------PAYGADVLRWwvaesNVFSEVQIGPSA------LSSARDSISKLRNT 731
Cdd:PTZ00419 605 lqdlnqklyeGNLPEKeikraielqkkefpngiPECGTDALRF-----GLLAYTQQGRNInldinrVVGYRHFCNKLWNA 679
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 732 LKFLLGNLQGFDPRL-----QAVDPKQMHYIDQYMLHLLREYSIKVTDAYSEFDAGRVIRVLQAFITRELSSFYFSIIKD 806
Cdd:PTZ00419 680 VKFALMKLLKDFNLPnstlfKPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKP 759
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 807 RLyCDAEDSLGRRSCQTVLEEILDGVTRSIAPILPHMAEEVYLHAPGH-DKEETLFKSGWIKSSSVWRRPGLEEAVEGAC 885
Cdd:PTZ00419 760 RL-SKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYlRKSESISIAKYPQPNPGWNNEALDEEMKIIM 838
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 886 AIRDSFLS-----SIPGKNaaRYDLTVAIEPGLLFELMESlQEEPTSTTSQLAELMMAARVNLATKMPRDLDPEALLNHG 960
Cdd:PTZ00419 839 SIVKSIRSliatlGIPNKT--KPDCYVTAKDAELIELIES-AENLISTLAKIGSVSVIPPIEEEAEVPKGCGFDVVDNKV 915
|
970
....*....|
gi 2062420168 961 TFLINLEGGV 970
Cdd:PTZ00419 916 IIYLNLDEFI 925
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
119-703 |
3.22e-49 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 179.36 E-value: 3.22e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 119 PPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKALGDLGTSG-----LSPLQIRQKAREFAEGA 193
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGktrhdLGREEFLEKCWEWKEES 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 194 IARQKAAFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAEleynpehvsraiya 273
Cdd:cd00817 89 GGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIE-------------- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 274 tfplvtlppkiasqegmesvsvlvwttqpwtipanqaVCYmpnaqysvvkradnsekflvateRTasiaallgtdlqtvg 353
Cdd:cd00817 155 -------------------------------------VCS-----------------------RS--------------- 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 354 tftgslleggickhptipdkqvpllpanhvtmvkgtglvhtapahgmedysvasqfKLPVECMVdedgtfnelagpelqk 433
Cdd:cd00817 160 --------------------------------------------------------GDVIEPLL---------------- 167
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 434 lsvmtegndkvismlkqcnallkeeqcvhsypydwrTKQpvvirpskqWFINTESLKDKAKEALQKVRV--LPESARSSL 511
Cdd:cd00817 168 ------------------------------------KPQ---------WFVKVKDLAKKALEAVKEGDIkfVPERMEKRY 202
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 512 LTMLDRRTYWCISRQRSWGVPIPVFYHKESGEALINKYTVSHIAQLFKEKGSDCwwelpietllppevlkkskagAASDY 591
Cdd:cd00817 203 ENWLENIRDWCISRQLWWGHRIPAWYCKDGGHWVVAREEDEAIDKAAPEACVPC---------------------GGEEL 261
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 592 VRGEDVLDIWFDSGASWAAVL---EAESDSRA----DIYVEGKDQIGGW-FqqSSLLTSVAVRNKAPYKSLVVHGFAVSE 663
Cdd:cd00817 262 KQDEDVLDTWFSSSLWPFSTLgwpEETKDLKKfyptSLLVTGHDIIFFWvA--RMIMRGLKLTGKLPFKEVYLHGLVRDE 339
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 2062420168 664 KGEKMSKSVGNVVDPDVVINGgkdptepaYGADVLRWWVA 703
Cdd:cd00817 340 DGRKMSKSLGNVIDPLDVIDG--------YGADALRFTLA 371
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
471-703 |
5.63e-39 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 147.57 E-value: 5.63e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 471 KQPVVIRPSKQWFINTESLKDKAKEALQKVRVLPESARSSLLTMLDRRTYWCISRQRSWGVPIPvfyhkesgealinkyt 550
Cdd:cd00668 131 RGTHPVRITEQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP---------------- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 551 vshiaqlfkekgsdcwwelpietllppevlkkskagaasdyvrgEDVLDIWFDSGASWAAVLEAESDSR-------ADIY 623
Cdd:cd00668 195 --------------------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEwfkdsypADWH 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 624 VEGKDQIGGWFQqSSLLTSVAVRNKAPYKSLVVHGFAVSEKGEKMSKSVGNVVDPDVVINggkdptepAYGADVLRWWVA 703
Cdd:cd00668 231 LIGKDILRGWAN-FWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVE--------KYGADALRYYLT 301
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
112-275 |
1.05e-37 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 143.71 E-value: 1.05e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 112 KFCLHDGPPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKA--LGDLGTSGLSPLQIRQKAREF 189
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerKGGRKKKTIWIEEFREDPKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 190 AEGAIARQKAAFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPS---SGTALAEAELEYN--- 263
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPVRITEQwffDMPKFKEKLLKALrrg 160
|
170
....*....|....*
gi 2062420168 264 ---PEHVSRAIYATF 275
Cdd:cd00668 161 kivPEHVKNRMEAWL 175
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
126-855 |
7.75e-36 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 146.94 E-value: 7.75e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 126 PHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPI---------------------------ELKALGDlgtsgls 178
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPIlgiaeriargdpetielykslygipeeELEKFKD------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 179 PLQIrqkAREFAEGAiarqKAAFQRWGVMADWDQCYYTFDGTYEAA---QLKVFQEmhsKGLIYQDYKPVFWSPSSGTAL 255
Cdd:PRK12300 74 PEYI---VEYFSEEA----KEDMKRIGYSIDWRREFTTTDPEYSKFiewQFRKLKE---KGLIVKGSHPVRYCPNDNNPV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 256 --------AEAE-LEYNpehvsrAIYatFplvtlppkiasqEGMESVSVLVWTTQPWTIPANQAVCYMPNAQYSVVKRad 326
Cdd:PRK12300 144 gdhdlldgEEPEiVEYT------LIK--F------------EESEDLILPAATLRPETIFGVTNLWVNPDATYVKAEV-- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 327 NSEKFLVATErTASIAALLGTDLQTVGTFTGSLLEGGICKHPtIPDKQVPLLPANHVTMVKGTGLVHTAPAHGMEDY--- 403
Cdd:PRK12300 202 DGEKWIVSKE-AAEKLSFQDRDVEIIEEIKGSELIGKKVKNP-VTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYval 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 404 -------SVASQFKLPVECMVDEDGTFN-----ELAG------PELQKLS-----------VMT------------EGND 442
Cdd:PRK12300 280 rdlkknkELLDVIEPIPLIEVEGYGEFPakevvEKLGiksqedPELEEATkevyraefhkgVLKentgeyagkpvrEARE 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 443 KVISMLKQCNALLK----EEQCVHSypydwRTKQPVVIRPSK-QWFIN--TESLKDKAKEALQKVRVLPESARSSLLTML 515
Cdd:PRK12300 360 KITKDLIEKGIADImyefSNRPVYC-----RCGTECVVKVVKdQWFIDysDPEWKELAHKALDNMEIIPEEYRKEFENTI 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 516 DRRTYWCISRQRSWGVPIPvFYHKESGEALINK------YTVSHIAQLFKEKGSDcwwelpietlLPPEVLkkskagaas 589
Cdd:PRK12300 435 DWLKDRACARRRGLGTRLP-WDEEWIIESLSDStiymayYTIAHKIREYGIKPEQ----------LTPEFF--------- 494
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 590 DYV-RGE-DVLDIWFDSGASWAAVLEAES--------DSRadiyVEGKDQIGGW--FQqssLLTSVAV--RNKAPyKSLV 655
Cdd:PRK12300 495 DYVfLGKgDPEEVSKKTGIPKEILEEMREeflywypvDWR----HSGKDLIPNHltFF---IFNHVAIfpEEKWP-RGIV 566
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 656 VHGFAVSEkGEKMSKSVGNVVDPDVVINggkdptepAYGADVLRWWVAES-NVFSEVQIGPSALSSARDSISKLRNTLKF 734
Cdd:PRK12300 567 VNGFVLLE-GKKMSKSKGNVIPLRKAIE--------EYGADVVRLYLTSSaELLQDADWREKEVESVRRQLERFYELAKE 637
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 735 LLGnlqgfdprlqAVDPKQMHYIDQYMLHLLREYSIKVTDAYSEFDagrvIRvlQAFItrelsSFYFSIIKD-RLYCDae 813
Cdd:PRK12300 638 LIE----------IGGEEELRFIDKWLLSRLNRIIKETTEAMESFQ----TR--DAVQ-----EAFYELLNDlRWYLR-- 694
|
810 820 830 840
....*....|....*....|....*....|....*....|..
gi 2062420168 814 dsLGRRSCQTVLEEILDGVTRSIAPILPHMAEEVYlHAPGHD 855
Cdd:PRK12300 695 --RVGEANNKVLREVLEIWIRLLAPFTPHLAEELW-HKLGGE 733
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
119-878 |
8.23e-34 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 140.80 E-value: 8.23e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 119 PPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLP----IELKAL-------GDLGTSGLSPLQIRQKaR 187
Cdd:PLN02381 136 PPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIAtqvvVEKKLMrerhltrHDIGREEFVSEVWKWK-D 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 188 EFAeGAIARQkaaFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAELEY----- 262
Cdd:PLN02381 215 EYG-GTILNQ---LRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYidike 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 263 ----------NPEHVSRAIYATFPLvtlppkiasQEGMESVsvLVWTTQPWTIPANQAVCYMP-NAQYSvvkradnsekf 331
Cdd:PLN02381 291 rtllkvpgydKPVEFGVLTSFAYPL---------EGGLGEI--VVATTRIETMLGDTAIAIHPdDERYK----------- 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 332 lvatertasiaallgtdlqtvgtftgsLLEGGICKHPTIPDKQVPLLPANHVTMVKGTGLVHTAPAHGMEDYSVASQFKL 411
Cdd:PLN02381 349 ---------------------------HLHGKFAVHPFNGRKLPIICDAILVDPNFGTGAVKITPAHDPNDFEVGKRHNL 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 412 PVECMVDEDGTFNELAGPELQKLSVMtEGNDKVISMLKQCNALLKEEQCVHSYPYDWRTKQPV--VIRPskQWFINTESL 489
Cdd:PLN02381 402 EFINIFTDDGKINSNGGSEFAGMPRF-AAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVepMIKP--QWFVNCSSM 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 490 kdkAKEALQ--------KVRVLPESARSSLLTMLDRRTYWCISRQRSWGVPIPVFYhkesgealinkytVSHIAQLFKEK 561
Cdd:PLN02381 479 ---AKQALDaaidgenkKLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWY-------------VTLEDDQLKEL 542
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 562 GS--DCWWELPIETLLPPEVLKKSkAGAASDYVRGEDVLDIWFDSGASWAAVL---EAESDSRA----DIYVEGKDQIGG 632
Cdd:PLN02381 543 GSynDHWVVARNESDALLEASQKF-PGKKFELSQDPDVLDTWFSSGLFPLSVLgwpDDTDDLKAfyptSVLETGHDILFF 621
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 633 WFQQSSLLtSVAVRNKAPYKSLVVHGFAVSEKGEKMSKSVGNVVDPDVVIN-------------GGKDPTE--------- 690
Cdd:PLN02381 622 WVARMVMM-GMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINgisleglhkrleeGNLDPKElvvakegqk 700
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 691 -------PAYGADVLRW----WVAESNvfsEVQIGPSALSSARDSISKLRNTLKFLLGNL-QGFDPRLqAVDPKQMHYID 758
Cdd:PLN02381 701 kdfpngiAECGTDALRFalvsYTAQSD---KINLDILRVVGYRQWCNKLWNAVRFAMSKLgDDYTPPA-TLSVETMPFSC 776
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 759 QYMLHLLREYSIKVTDAYSEFDAGRVIRVLQAFITRELSSFYFSIIKDRLYCDA-EDSLGRRSCQTVLEEILDGVTRSIA 837
Cdd:PLN02381 777 KWILSVLNKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNpEFASERAAAQDTLWICLDTGLRLLH 856
|
810 820 830 840
....*....|....*....|....*....|....*....|....
gi 2062420168 838 PILPHMAEEVYLHAP---GHDKEETLFKSGWIKSSSVWRRPGLE 878
Cdd:PLN02381 857 PFMPFVTEELWQRLPqpkDHTRKDSIMISEYPSAVEAWTNEKVE 900
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
120-865 |
1.85e-25 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 113.61 E-value: 1.85e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 120 PYANGDPHVGHALNKILKDIRNRFEMLRGRQV-HyiP-GWDCHGLPIELKALgdlgTSGLSPlqirqkaREFAEGAIARQ 197
Cdd:COG0495 42 PYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVlH--PmGWDAFGLPAENAAI----KNGVHP-------AEWTYENIANM 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 198 KAAFQRWGVMADWDQ----C---YY--TfdgtyeaaQlKVFQEMHSKGLIYQDYKPVFWSPSSGTALA-E---------- 257
Cdd:COG0495 109 RRQLKRLGLSYDWSReiatCdpeYYkwT--------Q-WIFLQLYEKGLAYRKEAPVNWCPVDQTVLAnEqvidgrcwrc 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 258 -------------------AE--------LEYNPEHV----------SRAIYATFPLVtlppkiASQEGMEsvsvlVWTT 300
Cdd:COG0495 180 gapvekkelpqwflkitdyADellddldkLDGWPEKVktmqrnwigrSEGAEVDFPVE------GSDEKIT-----VFTT 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 301 QPWTIpanQAVCYM------PNAQySVVKRADNSE--KFLVATERTASIAALLGTDLQTvGTFTGSLleggiCKHPtIPD 372
Cdd:COG0495 249 RPDTL---FGATFMvlapehPLVK-ELATPEQNAAvaAFIEEAKKKSEIERTSETKEKT-GVFTGLY-----AINP-LTG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 373 KQVPLLPANHVTMVKGTGLVHTAPAHGMEDYSVASQFKLPVECMVDedgtfnelaGPELQKLSVMTEgndkvismlkqcn 452
Cdd:COG0495 318 EKIPIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIA---------PEDGDDPDILEE------------- 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 453 ALLKEEQCVHSYPYDWrtkqpvvirpskqwfINTESLKDKAKEALQ-----KVRVlpesarsslltmldrrTY----WCI 523
Cdd:COG0495 376 AYTGDGVLINSGEFDG---------------LDSEEAKEAIIEWLEekglgKRKV----------------NYrlrdWLI 424
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 524 SRQRSWGVPIPVfYHKESGEAlinkYTVshiaqlfKEKgsdcwwELPIEtlLPPEV---------LKKS---------KA 585
Cdd:COG0495 425 SRQRYWGEPIPI-IHCEDCGV----VPV-------PED------QLPVE--LPEDVdfdptggspLARApewvnvtcpKC 484
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 586 GAAsdYVRGEDVLDIWFDSgaSW-----------AAVLEAEsdsRADiY---VegkDQ-IGG-------------Wfqqs 637
Cdd:COG0495 485 GGP--ARRETDTMDTFVDS--SWyylrytdphndEAPFDPE---AAN-YwlpV---DQyIGGiehailhllyarfF---- 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 638 sllTSV-----AVRNKAPYKSLVVHG--------FAVSEKGEKMSKSVGNVVDPDVVINggkdptepAYGADVLRWWVae 704
Cdd:COG0495 550 ---TKVlrdlgLVSFDEPFKRLLTQGmvlevgkdGVVIGGIEKMSKSKGNVVDPDEIIE--------KYGADTLRLFE-- 616
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 705 snVFsevqIGP---------SALSSARdsisklrntlKFL-------LGNLQGFDPRLQAVDPKQmhyidqymLHLLREY 768
Cdd:COG0495 617 --MF----AGPperdlewsdSGVEGAY----------RFLnrvwrlvVDEAEALKLDVADLSEAD--------KELRRAL 672
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 769 --SI-KVTDAYSEFdagrvirvlqAFIT-----RELSSFyfsiikdrLYcDAEDSLGRRSCqtVLEEILDGVTRSIAPIL 840
Cdd:COG0495 673 hkTIkKVTEDIERL----------RFNTaiaalMELVNA--------LY-KAKDSGEADRA--VLREALETLVLLLAPFA 731
|
890 900
....*....|....*....|....*
gi 2062420168 841 PHMAEEVYlHAPGHdkEETLFKSGW 865
Cdd:COG0495 732 PHIAEELW-ERLGH--EGSVADAPW 753
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
758-882 |
1.96e-23 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 97.09 E-value: 1.96e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 758 DQYMLHLLREYSIKVTDAYSEFDAGRVIRVLQAFITRELSSFYFSIIKDRLYCDAEDSLgrrsCQTVLEEILDGVTRSIA 837
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSR----AQTTLYEVLETLLRLLA 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2062420168 838 PILPHMAEEVYlhapghdKEETLFKSGWIKSSSVWrRPGLEEAVE 882
Cdd:pfam08264 77 PFMPFITEELW-------QKESIHLAPWPEDAELE-EAELEEAFE 113
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
110-699 |
7.17e-23 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 105.29 E-value: 7.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 110 KNKFCLHDGPPYANGDP-HVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKALgDLGTsglsplqirqKARE 188
Cdd:PLN02563 109 KPKFYVLDMFPYPSGAGlHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAEQYAI-ETGT----------HPKI 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 189 FAEGAIARQKAAFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAELeynPEHVS 268
Cdd:PLN02563 178 TTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEV---VDGLS 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 269 -RAIYatfPLVTLPPK---------------------------------IASQEGME-------------SVSVLVWTTQ 301
Cdd:PLN02563 255 eRGGH---PVIRKPMRqwmlkitayadrlledlddldwpesikemqrnwIGRSEGAEldfsvldgegkerDEKITVYTTR 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 302 PWTIPANQAVCYMPN----AQYSVVKRADNSEKFLVATERTASiaaLLGTDLQTV--GTFTGSLleggiCKHPTIPDKqV 375
Cdd:PLN02563 332 PDTLFGATYLVVAPEhpllSSLTTAEQKEAVEEYVDAASRKSD---LERTELQKEktGVFTGSY-----AINPATGEA-I 402
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 376 PLLPANHVTMVKGTGLVHTAPAHGMEDYSVASQFKLPVECMV---DEDGTFNELAGPElqklsvmtEGndkviSMLKQCN 452
Cdd:PLN02563 403 PIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVkpaDGNEDDAEKAYTG--------EG-----VIVNSSS 469
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 453 ALLKeeqcvhsypydwrtkqpvvirpskqwfINTESLKDKAKEALQKVRVLPESARSSLLTMLDrrtyWCISRQRSWGVP 532
Cdd:PLN02563 470 SGLD---------------------------INGLSSKEAAKKVIEWLEETGNGKKKVNYKLRD----WLFARQRYWGEP 518
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 533 IPVFYHKESGEALINKYTvshiaqlfkekgsdcwwELPIETllpPEV--LKKSKAGA-----ASDYVRGEDVLD-IWFD- 603
Cdd:PLN02563 519 IPVVFLEDSGEPVPVPES-----------------DLPLTL---PELddFTPTGTGEpplakAVSWVNTVDPSSgKPARr 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 604 --------SGASW-----------AAVLEAESD---SRADIYVEGKDQ-----IGGWFQQSSLLTSVAVRNKAPYKSLVV 656
Cdd:PLN02563 579 etntmpqwAGSCWyylrfmdpknsNALVDKEKEkywMPVDLYVGGAEHavlhlLYARFWHKVLYDIGVVSTKEPFQCLVN 658
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 657 HGF-------------------------------------AVSEKGE-----------------KMSKSVGNVVDPDVVI 682
Cdd:PLN02563 659 QGMilgeveytafkdsdgeyvsadtadrlgelqqekipeeKVIKSGDsfvlkddpsirliarahKMSKSRGNVVNPDDVV 738
|
730
....*....|....*..
gi 2062420168 683 NggkdptepAYGADVLR 699
Cdd:PLN02563 739 S--------EYGADSLR 747
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
120-703 |
3.98e-19 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 92.10 E-value: 3.98e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 120 PYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKALGDlgtsGLSPlqirqkaREFAEGAIARQKA 199
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKE----GITP-------QELVDRIHAEFKE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 200 AFQRWGVmaDWDQcYY--TFDGTYEAAQlKVFQEMHSKGLIYQDykpvfwspssgtalaeaeleynpehvsraiyatfpl 277
Cdd:COG0143 79 LFEKLGI--SFDN-FIrtTSPEHKELVQ-EIFQRLYDNGDIYKG------------------------------------ 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 278 vtlppkiaSQEGMesvsvlvwttqpwtipanqavcympnaqYSVVKradnsEKFLvaTERTasiaallgtdlqtvgtftg 357
Cdd:COG0143 119 --------EYEGW----------------------------YCPEC-----ERFL--PDRY------------------- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 358 slleggickhptipdkqvpllpanhvtmVKGtglvhTAPAHGMEDysvasqfklpvecmvdedgtfnelagpelqklsvm 437
Cdd:COG0143 137 ----------------------------VEG-----TCPKCGAED----------------------------------- 148
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 438 tegndkviSMLKQCnallkeEQCVHSY-------PYDWRTKQPVVIRPSKQWFINTESLKDKAKEALQKVRVLPESARSS 510
Cdd:COG0143 149 --------AYGDQC------ENCGATLeptelinPRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENPDIQPEVRNE 214
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 511 LLTMLDRR-TYWCISRQRSWGVPIP-----VFYhkesgEALINkYtVSHIAQLFKEKGSDC----WWelpietllppevl 580
Cdd:COG0143 215 VLSWLKEGlQDLSISRDFDWGIPVPgdpgkVFYvw--fDALIG-Y-ISATKGYADDRGLPEdfekYW------------- 277
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 581 kksKAGAASDY-VRGEDVldIWFDSgASWAAVLEAesdsrADIyvegkdqiggwfqqsslltsvavrnkAPYKSLVVHGF 659
Cdd:COG0143 278 ---PAPDTELVhFIGKDI--IRFHA-IIWPAMLMA-----AGL--------------------------PLPKKVFAHGF 320
|
570 580 590 600
....*....|....*....|....*....|....*....|....
gi 2062420168 660 AVSEkGEKMSKSVGNVVDPDVVINggkdptepAYGADVLRWWVA 703
Cdd:COG0143 321 LTVE-GEKMSKSRGNVIDPDDLLD--------RYGPDALRYYLL 355
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
120-257 |
1.34e-18 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 87.97 E-value: 1.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 120 PYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKALgdlgTSGLSPlqirqkaREFAEGAIARQKA 199
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAE----EEGVTP-------QELCDKYHEIFKD 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2062420168 200 AFQRWGVmaDWDqcYY---TFDGTYEAAQlKVFQEMHSKGLIYQD-YKpVFWSPSSGTALAE 257
Cdd:cd00814 78 LFKWLNI--SFD--YFirtTSPRHKEIVQ-EFFKKLYENGYIYEGeYE-GLYCVSCERFLPE 133
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
120-261 |
4.90e-18 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 87.35 E-value: 4.90e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 120 PYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKALgdlgTSGLSPlqirqkaREFAEGAIARQKA 199
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAE----KEGITP-------EELVDRYHEIHRE 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2062420168 200 AFQRWGVMADwdqcYY---TFDGTYEAAQlKVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAELE 261
Cdd:pfam09334 77 DFKKFNISFD----DYgrtTSERHHELVQ-EFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE 136
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
120-261 |
5.76e-17 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 85.51 E-value: 5.76e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 120 PYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKALgdlgTSGLSPLQIrqkarefaegaIARQKA 199
Cdd:TIGR00398 8 PYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAE----QEGLTPKEL-----------VDKYHE 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 200 AFQRwgvmaDWDQCYYTFDG--------TYEAAQlKVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAELE 261
Cdd:TIGR00398 73 EFKD-----DWKWLNISFDRfirttdeeHKEIVQ-KIFQKLKENGYIYEKEIKQLYCPECEMFLPDRYVE 136
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
120-247 |
7.23e-17 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 82.68 E-value: 7.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 120 PYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKAlgdlgtsglspLQIRQKAREFAEGAIARQKA 199
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAA-----------IKIGRDPEDWTEYNIKKMKE 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2062420168 200 AFQRWGVMADWDQCYYTFDGTYEAAQLKVFQEMHSKGLIYQDYKPVFW 247
Cdd:cd00812 78 QLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
463-703 |
1.44e-16 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 81.91 E-value: 1.44e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 463 SYPYDWRtkqpvviRPSKQWFINT--ESLKDKAKEALQKVRVLPESARSSLLTMLDrrtywcISRQRSWGVPIPVFYHKE 540
Cdd:cd00812 120 EAPVNWC-------KLLDQWFLKYseTEWKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIPWTDTME 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 541 SgeaLIN------KYTVSHIAQLFKEKgsdcwwelpIETLLPPEVLKkskagaasdyvrgedvldiwfdsgasWAAVlea 614
Cdd:cd00812 187 S---LSDstwyyaRYTDAHNLEQPYEG---------DLEFDREEFEY--------------------------WYPV--- 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 615 esdsraDIYVEGKDQIGG--WFqqsSLLTSVAVRNKA-----PYKSLVVHGFAVSEkGEKMSKSVGNVVDPDVVINGgkd 687
Cdd:cd00812 226 ------DIYIGGKEHAPNhlLY---SRFNHKALFDEGlvtdePPKGLIVQGMVLLE-GEKMSKSKGNVVTPDEAIKK--- 292
|
250
....*....|....*.
gi 2062420168 688 ptepaYGADVLRWWVA 703
Cdd:cd00812 293 -----YGADAARLYIL 303
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
722-882 |
6.57e-16 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 76.82 E-value: 6.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 722 RDSISKLRNTLKFLLG--NLQGFDPRLQAVDPKQMHYIDQYMLHLLREYSIKVTDAYSEFDAGRVIRVLQAFITrELSSF 799
Cdd:cd07961 11 RKVLLPLWNAYRFFVTyaNLDGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFID-ELTNW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 800 YFSIIKDRLYcDAEDSLGRRSCQTVLEEILDGVTRSIAPILPHMAEEVY--LHAPGHDKEETLFKSGWIKSSSVWRRPGL 877
Cdd:cd07961 90 YIRRNRKRFW-GEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYqnLRRELGDAPESVHLLDWPEVDESLIDEEL 168
|
....*
gi 2062420168 878 EEAVE 882
Cdd:cd07961 169 EEAME 173
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
475-703 |
9.18e-16 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 79.50 E-value: 9.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 475 VIRPSKQWFINTESLKDKAKEALQK--VRVLPESARSSLLTMLDRRTY-WCISRQRS-WGVPIP-----VFYhkESGEAL 545
Cdd:cd00814 133 EWREEEHYFFRLSKFQDRLLEWLEKnpDFIWPENARNEVLSWLKEGLKdLSITRDLFdWGIPVPldpgkVIY--VWFDAL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 546 INkYtVSHIAQLFKEKGSDCWWelpietllppevlkkskagaasdyvrgedvLDIWfdsgaswaavleaesdsRADIYVE 625
Cdd:cd00814 211 IG-Y-ISATGYYNEEWGNSWWW------------------------------KDGW-----------------PELVHFI 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 626 GKDQIggWFQQ----SSLLtsvAVRNKAPYKsLVVHGFAVSEkGEKMSKSVGNVVDPDVVINggkdptepAYGADVLRWW 701
Cdd:cd00814 242 GKDII--RFHAiywpAMLL---GAGLPLPTR-IVAHGYLTVE-GKKMSKSRGNVVDPDDLLE--------RYGADALRYY 306
|
..
gi 2062420168 702 VA 703
Cdd:cd00814 307 LL 308
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
727-848 |
9.58e-15 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 71.82 E-value: 9.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 727 KLRNTLKFLLGNLQGFDPrlQAVDPKQMHYIDQYMLHLLREYSIKVTDAYSEFDAGRVIRVLQAFITRELSSFYFSIIKD 806
Cdd:cd07962 15 KLWNAARFVLMNLEDDDE--PEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWNDFCDWYLELVKP 92
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2062420168 807 RLYcdAEDSLGRRSCQTVLEEILDGVTRSIAPILPHMAEEVY 848
Cdd:cd07962 93 RLY--GEDEEEKKAARATLYYVLETILRLLHPFMPFITEELW 132
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
120-239 |
1.78e-12 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 71.34 E-value: 1.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 120 PYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKALGDlgtsGLSPLQIrqkarefaegaIARQKA 199
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKE----GITPEEL-----------IARYHA 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2062420168 200 AFQRwgvmaDWDQCYYTFD--GT------YEAAQlKVFQEMHSKGLIY 239
Cdd:PRK00133 76 EHKR-----DFAGFGISFDnyGSthseenRELAQ-EIYLKLKENGYIY 117
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
718-840 |
4.12e-11 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 60.98 E-value: 4.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 718 LSSARDSISKLRNTLKFLLGNLQGFDPRLQAVDPKQMhyiDQYMLHLLREYSIKVTDAYSEFDAGRVIRVLQAFiTRELS 797
Cdd:cd07375 4 LKQARAFLNRLYRLLSFFRKALGGTQPKWDNELLEEA---DRELLARLQEFIKRTTNALEALDPTTAVQELFKF-TNELN 79
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 2062420168 798 SFYfsiikDRLYCDAEDSLGRRSCQTVLEEILDGVTRSIAPIL 840
Cdd:cd07375 80 WYL-----DELKPALQTEELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
119-260 |
1.43e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 64.90 E-value: 1.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 119 PPYANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKALgdlgTSGLSPlqirqkaREFAegaiARQK 198
Cdd:PRK11893 9 IYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAE----EAGISP-------QELA----DRNS 73
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 199 AAFQRwgvmaDWDQCYYTFD--------GTYEAAQlKVFQEMHSKGLIYQDYKPVFWSPSSGTALAEAEL 260
Cdd:PRK11893 74 AAFKR-----LWEALNISYDdfirttdpRHKEAVQ-EIFQRLLANGDIYLGKYEGWYCVRCEEFYTESEL 137
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
650-699 |
6.30e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 59.81 E-value: 6.30e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 2062420168 650 PYKSLVVHGFAVSeKGEKMSKSVGNVVDPDVVINggkdptepAYGADVLR 699
Cdd:PRK12267 283 LPKKVFAHGWWLM-KDGKMSKSKGNVVDPEELVD--------RYGLDALR 323
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
652-860 |
4.21e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 56.81 E-value: 4.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 652 KSLVVHGFAVSEkGEKMSKSVGNVVDPDVVINggkdptepAYGADVLRWWVAesnvfSEVQIG-PSALSsaRDSISKLRN 730
Cdd:PRK11893 285 KRVFAHGFLTLD-GEKMSKSLGNVIDPFDLVD--------EYGVDAVRYFLL-----REIPFGqDGDFS--REAFINRIN 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 731 -------------TLKFLLGNLQGFDPRLQAVDPKqmhyiDQYMLHLLREYSIKVTDAYSEFDAGRVIRVLQAFitrels 797
Cdd:PRK11893 349 adlandlgnlaqrTLSMIAKNFDGKVPEPGALTEA-----DEALLEAAAALLERVRAAMDNLAFDKALEAILAL------ 417
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2062420168 798 sfyfsIIKDRLYCDAED--SLgRRSCQTVLEEILDGVTRSI-------APILPHMAEEVyLHAPGHDKEETL 860
Cdd:PRK11893 418 -----VRAANKYIDEQApwSL-AKTDPERLATVLYTLLEVLrgiavllQPVMPELAAKI-LDQLGVEEDENR 482
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
121-239 |
5.59e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 56.73 E-value: 5.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 121 YANGDPHVGHALNKILKDIRNRFEMLRGRQVHYIPGWDCHGLPIELKAlgdlGTSGLSPlqirqkaREFAEGAIARQKAA 200
Cdd:PRK12267 14 YPNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQQAA----EKAGKTP-------QEYVDEISAGFKEL 82
|
90 100 110
....*....|....*....|....*....|....*....
gi 2062420168 201 FQRWGVmaDWDQCYYTFDGTYEAAQLKVFQEMHSKGLIY 239
Cdd:PRK12267 83 WKKLDI--SYDKFIRTTDERHKKVVQKIFEKLYEQGDIY 119
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
756-848 |
2.08e-06 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 47.59 E-value: 2.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 756 YIDQYMLHLLREYSIKVTDAYSEFDagrvirvlqafiTRE-LSSFYFSIIKD-RLYcdaEDSLGRRSCQTVLEEILDGVT 833
Cdd:cd07959 35 FIDRWLLSRLNRLIKETTEAYENMQ------------FREaLKEGLYELQNDlDWY---RERGGAGMNKDLLRRFIEVWT 99
|
90
....*....|....*
gi 2062420168 834 RSIAPILPHMAEEVY 848
Cdd:cd07959 100 RLLAPFAPHLAEEIW 114
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
353-414 |
1.70e-04 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 43.69 E-value: 1.70e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2062420168 353 GTFTGSlleggICKHPtIPDKQVPLLPANHVTMVKGTGLVHTAPAHGMEDYSVASQFKLPVE 414
Cdd:pfam13603 82 GVFTGL-----YAIHP-ITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIK 137
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
665-751 |
5.29e-04 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 43.55 E-value: 5.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 665 GEKMSKSVGNVVDPDVVINggkdptepAYGADVLRWWVAESN-----VFSEvqigpSALSSARDSISKLRNTLKFLLGNL 739
Cdd:COG0215 263 GEKMSKSLGNFFTVRDLLK--------KYDPEVLRFFLLSAHyrsplDFSE-----EALEEAEKALERLYNALRRLEEAL 329
|
90
....*....|..
gi 2062420168 740 QGFDPRLQAVDP 751
Cdd:COG0215 330 GAADSSAEEIEE 341
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
120-241 |
3.95e-03 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 41.30 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062420168 120 PYANGDPHVGHALNKILK-DIRNRFEMLRGRQVHYIPGWDCHGLPIELKALGDlgtsGLSPLQIRQKARefaegAIARQk 198
Cdd:PLN02610 26 PYVNNVPHLGNIIGCVLSaDVFARYCRLRGYNAIYICGTDEYGTATETKALEE----NCTPKEICDKYH-----AIHKE- 95
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2062420168 199 aafqrwgvMADW-DQCYYTFDGTYEAAQLKV----FQEMHSKGLIYQD 241
Cdd:PLN02610 96 --------VYDWfDISFDKFGRTSTPQQTEIcqaiFKKLMENNWLSEN 135
|
|
| |
