NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|923800521|ref|XP_013765422|]
View 

PREDICTED: complement decay-accelerating factor isoform X3 [Pundamilia nyererei]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 55-203 2.60e-15

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 74.69  E-value: 2.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923800521  55 VTLECSSGY--IKESGS--EFITCINDQWTESELICKKKDCGQPPPKPHMKFDTSQGTLF-GVLVKVTCEKGYQISGSSY 129
Cdd:PHA02927 108 ITYSCNSGYqlIGESKSycELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYEDFYTdGSVVTYSCNSGYSLIGNSG 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 923800521 130 KECYDQGWSGRASCEIVTCDKPAIANGNTSWDSGDDPEYNNTIRYTCHEGYTLIGSDTVVCDETGEYSPDQPVC 203
Cdd:PHA02927 188 VLCSGGEWSDPPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 55-203 2.60e-15

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 74.69  E-value: 2.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923800521  55 VTLECSSGY--IKESGS--EFITCINDQWTESELICKKKDCGQPPPKPHMKFDTSQGTLF-GVLVKVTCEKGYQISGSSY 129
Cdd:PHA02927 108 ITYSCNSGYqlIGESKSycELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYEDFYTdGSVVTYSCNSGYSLIGNSG 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 923800521 130 KECYDQGWSGRASCEIVTCDKPAIANGNTSWDSGDDPEYNNTIRYTCHEGYTLIGSDTVVCDETGEYSPDQPVC 203
Cdd:PHA02927 188 VLCSGGEWSDPPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 148-203 7.06e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 7.06e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 923800521 148 CDKP-AIANGnTSWDSGDDPEYNNTIRYTCHEGYTLIGSDTVVCDETGEYSPDQPVC 203
Cdd:cd00033    1 CPPPpVPENG-TVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 148-203 2.03e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.91  E-value: 2.03e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 923800521   148 CDKP-AIANGnTSWDSGDDPEYNNTIRYTCHEGYTLIGSDTVVCDETGEYSPDQPVC 203
Cdd:smart00032   1 CPPPpDIENG-TVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
148-203 8.13e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.57  E-value: 8.13e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 923800521  148 CDKP-AIANGntsWDSGDDPEYN--NTIRYTCHEGYTLIGSDTVVCDETGEYSPDQPVC 203
Cdd:pfam00084   1 CPPPpDIPNG---KVSATKNEYNygASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 55-203 2.60e-15

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 74.69  E-value: 2.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923800521  55 VTLECSSGY--IKESGS--EFITCINDQWTESELICKKKDCGQPPPKPHMKFDTSQGTLF-GVLVKVTCEKGYQISGSSY 129
Cdd:PHA02927 108 ITYSCNSGYqlIGESKSycELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYEDFYTdGSVVTYSCNSGYSLIGNSG 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 923800521 130 KECYDQGWSGRASCEIVTCDKPAIANGNTSWDSGDDPEYNNTIRYTCHEGYTLIGSDTVVCDETGEYSPDQPVC 203
Cdd:PHA02927 188 VLCSGGEWSDPPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 148-203 7.06e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 7.06e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 923800521 148 CDKP-AIANGnTSWDSGDDPEYNNTIRYTCHEGYTLIGSDTVVCDETGEYSPDQPVC 203
Cdd:cd00033    1 CPPPpVPENG-TVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 148-203 2.03e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.91  E-value: 2.03e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 923800521   148 CDKP-AIANGnTSWDSGDDPEYNNTIRYTCHEGYTLIGSDTVVCDETGEYSPDQPVC 203
Cdd:smart00032   1 CPPPpDIENG-TVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 48-203 1.64e-08

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 54.61  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923800521  48 VFPENIMVTLECSSGYikesGSEFITCINDQWTESELICKKKDCGQPPPKPHMKFDTSQGTL-FGVLVKVTCE----KGY 122
Cdd:PHA02831  39 VYEENENLEYKCNNNF----DKVFVTCNNGSWSTKNMCIGKRNCKDPVTILNGYIKNKKDQYsFGDSVTYACKvnklEKY 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923800521 123 QISGSSYKECYDQGWSGRAS-CEIVTCDKPAIANGNTSwDSGDDPEYNNTIRYTCHEGYTLIGSDTVVCDETGEYSPDQP 201
Cdd:PHA02831 115 SIVGNETVKCINKQWVPKYPvCKLIRCKYPALQNGFLN-VFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIP 193


                 ..
gi 923800521 202 VC 203
Cdd:PHA02831 194 KC 195
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 91-238 2.30e-08

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 54.27  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923800521  91 CGQPPPKP-HMKFDTSQGTL------FGVLVKVTCEKGY--QISGSSYKECYDQGWSGRASCEIVTCDKPA-IANGNTsw 160
Cdd:PHA02927  20 CCTIPSRPiNMKFKNSVETDananynIGDTIEYLCLPGYrkQKMGPIYAKCTGTGWTLFNQCIKRRCPSPRdIDNGQL-- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923800521 161 DSGDdPEYNNTIRYTCHEGYTLIGSDTVVCD--ETGE--YSPDQPVCNEVT-RAPATTSQPQVAITDLTTTDAKVSTFSD 235
Cdd:PHA02927  98 DIGG-VDFGSSITYSCNSGYQLIGESKSYCElgSTGSmvWNPEAPICESVKcQSPPSISNGRHNGYEDFYTDGSVVTYSC 176


                 ...
gi 923800521 236 SSA 238
Cdd:PHA02927 177 NSG 179
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 110-203 3.63e-08

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 53.94  E-value: 3.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923800521 110 FGVLVKVTCEKGYQISGSSYKECYDQGWSGRASCEiVTCDKPAIANGNTswdSGDDPEYNNTIRYTCHEGYTLIGSDTVV 189
Cdd:PHA02954 149 FGEHITINCDVGYEVIGASYISCTANSWNVIPSCQ-QKCDIPSLSNGLI---SGSTFSIGGVIHLSCKSGFTLTGSPSST 224

                         90
                 ....*....|....
gi 923800521 190 CDEtGEYSPDQPVC 203
Cdd:PHA02954 225 CID-GKWNPVLPIC 237
PHA02639 PHA02639
EEV host range protein; Provisional
 28-203 8.51e-08

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 52.74  E-value: 8.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923800521  28 CPKPEGGNNTVLTNeslLKNVFPENIMVTLECSSGYiKESGSEFITCINDQ----WTESELICKKKDCGQPPPKPHMK-F 102
Cdd:PHA02639  22 CDKPDDISNGFITE---LMEKYEIGKLIEYTCNTDY-ALIGDRFRTCIKDKnnaiWSNKAPFCMLKECNDPPSIINGKiY 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923800521 103 DTSQGTLFGVLVKVTC--EKGYQIS--GSSYKEC-YDQGWSGRAS-CEIVTCDKPAIANGNTSWDSGDDPEYNNT-IRYT 175
Cdd:PHA02639  98 NKREMYKVGDEIYYVCneHKGVQYSlvGNEKITCiQDKSWKPDPPiCKMINCRFPALQNGYINGIPSNKKFYYKTrVGFS 177

                        170       180
                 ....*....|....*....|....*...
gi 923800521 176 CHEGYTLIGSDTVVCDETGEYSPDQPVC 203
Cdd:PHA02639 178 CKSGFDLVGEKYSTCNINATWFPSIPTC 205
PHA02639 PHA02639
EEV host range protein; Provisional
 111-211 3.05e-07

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 51.20  E-value: 3.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923800521 111 GVLVKVTCEKGYQISGSSYKECYDQG----WSGRAS-CEIVTC-DKPAIANGNTsWDSGDDPEYNNTIRYTCHE----GY 180
Cdd:PHA02639  43 GKLIEYTCNTDYALIGDRFRTCIKDKnnaiWSNKAPfCMLKECnDPPSIINGKI-YNKREMYKVGDEIYYVCNEhkgvQY 121

                         90       100       110
                 ....*....|....*....|....*....|..
gi 923800521 181 TLIGSDTVVCDETGEYSPDQPVCNEVT-RAPA 211
Cdd:PHA02639 122 SLVGNEKITCIQDKSWKPDPPICKMINcRFPA 153
Sushi pfam00084
Sushi repeat (SCR repeat);
148-203 8.13e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.57  E-value: 8.13e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 923800521  148 CDKP-AIANGntsWDSGDDPEYN--NTIRYTCHEGYTLIGSDTVVCDETGEYSPDQPVC 203
Cdd:pfam00084   1 CPPPpDIPNG---KVSATKNEYNygASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 91-144 8.10e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.84  E-value: 8.10e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 923800521  91 CGQPPPKPHMKFDTSQGT-LFGVLVKVTCEKGYQISGSSYKECYDQG-WSGRA-SCE 144
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVGSSTITCTENGgWSPPPpTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 91-141 6.84e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.20  E-value: 6.84e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 923800521    91 CGQPPPKPHMKFDTSQGT-LFGVLVKVTCEKGYQISGSSYKECYDQG-WSGRA 141
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTySYGDTVTYSCDPGYTLIGSSTITCLENGtWSPPP 53
Sushi pfam00084
Sushi repeat (SCR repeat);
91-139 1.05e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 39.40  E-value: 1.05e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 923800521   91 CGQPPPKPHMKFDTSQG-TLFGVLVKVTCEKGYQISGSSYKECYDQG-WSG 139
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNeYNYGASVSYECDPGYRLVGSPTITCQEDGtWSP 51
PHA02817 PHA02817
EEV Host range protein; Provisional
 116-203 1.92e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 42.24  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923800521 116 VTCEKgyqiSGSSYKEcydqgwsgRASCEIVTCDKPAIANGNTSW-DSGDDPEYNNTIRYTCHEGYTLIGSDTVVCDETG 194
Cdd:PHA02817  69 IICEK----DGKWNKE--------FPVCKIIRCRFPALQNGFVNGiPDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINS 136


                 ....*....
gi 923800521 195 EYSPDQPVC 203
Cdd:PHA02817 137 SWIPKVPIC 145
PHA02817 PHA02817
EEV Host range protein; Provisional
 141-211 1.94e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 42.24  E-value: 1.94e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 923800521 141 ASCEIVTCD-KPAIANGNTsWDSGDDPEYNNTIRYTCHEG-----YTLIGSDTVVCDETGEYSPDQPVCNEV-TRAPA 211
Cdd:PHA02817  17 SLCDLNKCCyPPSIKNGYI-YNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCKIIrCRFPA 93
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 28-87 2.84e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.21  E-value: 2.84e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 923800521  28 CPKPEGGNNTVLTNEsllKNVFPENIMVTLECSSGYIKeSGSEFITCI-NDQWTESELICK 87
Cdd:cd00033    1 CPPPPVPENGTVTGS---KGSYSYGSTVTYSCNEGYTL-VGSSTITCTeNGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 28-86 5.86e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 34.81  E-value: 5.86e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 923800521    28 CPKPEGGNNTVLTNEsllKNVFPENIMVTLECSSGYIKeSGSEFITCIND-QWTESELIC 86
Cdd:smart00032   1 CPPPPDIENGTVTSS---SGTYSYGDTVTYSCDPGYTL-IGSSTITCLENgTWSPPPPTC 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH