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Conserved domains on  [gi|922553184|ref|XP_013604593|]
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PREDICTED: bifunctional L-3-cyanoalanine synthase/cysteine synthase C1, mitochondrial [Brassica oleracea var. oleracea]

Protein Classification

PALP domain-containing protein; threonine synthase( domain architecture ID 10791409)

PALP domain-containing protein belonging to the tryptophan synthase beta superfamily (fold type II) that consists of pyridoxal phosphate (PLP)-dependent enzymes that catalyze beta-replacement and beta-elimination reactions; threonine synthase catalyzes the final step of threonine biosynthesis, the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02556 PLN02556
cysteine synthase/L-3-cyanoalanine synthase
 1-368 0e+00

cysteine synthase/L-3-cyanoalanine synthase


:

Pssm-ID: 178171 [Multi-domain]  Cd Length: 368  Bit Score: 665.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184   1 MATIWRRLLKTETIPRISQSTRKLFSTDGSSSFAERLRNLPKEFPATQAKRDASLLIGRTPLVFLNRVTEGCGAYIAAKQ 80
Cdd:PLN02556   1 MAALLSRLKRRSSIPPSSHTLRKLFSTVGSPSFAQRLRDLPKDLPGTKIKTDASQLIGKTPLVYLNKVTEGCGAYIAAKQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  81 EHFQPTCSVKDRPALAMVADAEKKNLITPGKTTLIEPTSGNMGISMAFMAAMKGYKIIMTMPSYTSLERRVTMRSFGAEL 160
Cdd:PLN02556  81 EMFQPTSSIKDRPALAMIEDAEKKNLITPGKTTLIEPTSGNMGISLAFMAAMKGYKMILTMPSYTSLERRVTMRAFGAEL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 161 VLTDPTKGMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYDTTGPEIWEDTLGNVDIFVMGIGSGGTVSGVGQYLKFK 240
Cdd:PLN02556 161 VLTDPTKGMGGTVKKAYELLESTPDAFMLQQFSNPANTQVHFETTGPEIWEDTLGQVDIFVMGIGSGGTVSGVGKYLKSK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 241 NPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPDILDMDVMESVLEVSSEDAIKMARELALKEGLMVGISSGANTVA 320
Cdd:PLN02556 241 NPNVKIYGVEPAESNVLNGGKPGPHHITGNGVGFKPDILDMDVMEKVLEVSSEDAVNMARELALKEGLMVGISSGANTVA 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 922553184 321 AIRLAKMPENKGKLIVTIHASFGERYLSSILFDELRKEAEAMKPVSVD 368
Cdd:PLN02556 321 ALRLAKMPENKGKLIVTVHPSFGERYLSSVLFQELRKEAENMQPVSVD 368
 
Name Accession Description Interval E-value
PLN02556 PLN02556
cysteine synthase/L-3-cyanoalanine synthase
 1-368 0e+00

cysteine synthase/L-3-cyanoalanine synthase


Pssm-ID: 178171 [Multi-domain]  Cd Length: 368  Bit Score: 665.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184   1 MATIWRRLLKTETIPRISQSTRKLFSTDGSSSFAERLRNLPKEFPATQAKRDASLLIGRTPLVFLNRVTEGCGAYIAAKQ 80
Cdd:PLN02556   1 MAALLSRLKRRSSIPPSSHTLRKLFSTVGSPSFAQRLRDLPKDLPGTKIKTDASQLIGKTPLVYLNKVTEGCGAYIAAKQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  81 EHFQPTCSVKDRPALAMVADAEKKNLITPGKTTLIEPTSGNMGISMAFMAAMKGYKIIMTMPSYTSLERRVTMRSFGAEL 160
Cdd:PLN02556  81 EMFQPTSSIKDRPALAMIEDAEKKNLITPGKTTLIEPTSGNMGISLAFMAAMKGYKMILTMPSYTSLERRVTMRAFGAEL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 161 VLTDPTKGMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYDTTGPEIWEDTLGNVDIFVMGIGSGGTVSGVGQYLKFK 240
Cdd:PLN02556 161 VLTDPTKGMGGTVKKAYELLESTPDAFMLQQFSNPANTQVHFETTGPEIWEDTLGQVDIFVMGIGSGGTVSGVGKYLKSK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 241 NPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPDILDMDVMESVLEVSSEDAIKMARELALKEGLMVGISSGANTVA 320
Cdd:PLN02556 241 NPNVKIYGVEPAESNVLNGGKPGPHHITGNGVGFKPDILDMDVMEKVLEVSSEDAVNMARELALKEGLMVGISSGANTVA 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 922553184 321 AIRLAKMPENKGKLIVTIHASFGERYLSSILFDELRKEAEAMKPVSVD 368
Cdd:PLN02556 321 ALRLAKMPENKGKLIVTVHPSFGERYLSSVLFQELRKEAENMQPVSVD 368
cysK TIGR01139
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ...
 54-352 4.18e-144

cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273465  Cd Length: 298  Bit Score: 410.22  E-value: 4.18e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184   54 SLLIGRTPLVFLNRVtEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLITPGkTTLIEPTSGNMGISMAFMAAMK 133
Cdd:TIGR01139   2 SELIGNTPLVRLNRI-EGCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPG-KTIVEPTSGNTGIALAMVAAAR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  134 GYKIIMTMPSYTSLERRVTMRSFGAELVLTDPTKGMGGTVKKAYDLLESTPAAH-MLQQFANPANTQIHYDTTGPEIWED 212
Cdd:TIGR01139  80 GYKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSYfMLQQFENPANPEIHRKTTGPEIWRD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  213 TLGNVDIFVMGIGSGGTVSGVGQYLKFKNPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPDILDMDVMESVLEVSS 292
Cdd:TIGR01139 160 TDGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEVITVSD 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  293 EDAIKMARELALKEGLMVGISSGANTVAAIRLAKMPEnKGKLIVTIHASFGERYLSSILF 352
Cdd:TIGR01139 240 EEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPE-PDKLIVVILPSTGERYLSTPLF 298
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 56-349 9.83e-140

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 399.04  E-value: 9.83e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  56 LIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLITPGkTTLIEPTSGNMGISMAFMAAMKGY 135
Cdd:COG0031   10 LIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGLAMVAAAKGY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 136 KIIMTMPSYTSLERRVTMRSFGAELVLTDPTKGMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYDTTGPEIWEDTLG 215
Cdd:COG0031   89 RLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTGPEIWEQTDG 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 216 NVDIFV---------MGIgsggtvsgvGQYLKFKNPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPDILDMDVMES 286
Cdd:COG0031  169 KVDAFVagvgtggtiTGV---------GRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFVPKILDPSLIDE 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922553184 287 VLEVSSEDAIKMARELALKEGLMVGISSGANTVAAIRLAKMpENKGKLIVTIHASFGERYLSS 349
Cdd:COG0031  240 VITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKR-LGPGKTIVTILPDSGERYLST 301
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
 58-348 2.22e-137

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 392.65  E-value: 2.22e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  58 GRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLITPGkTTLIEPTSGNMGISMAFMAAMKGYKI 137
Cdd:cd01561    1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPG-TTIIEPTSGNTGIGLAMVAAAKGYRF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 138 IMTMPSYTSLERRVTMRSFGAELVLTDPTK--GMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYDTTGPEIWEDTLG 215
Cdd:cd01561   80 IIVMPETMSEEKRKLLRALGAEVILTPEAEadGMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 216 NVDIFV---------MGIgsggtvsgvGQYLKFKNPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPDILDMDVMES 286
Cdd:cd01561  160 KVDAFVagvgtggtiTGV---------ARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDE 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 922553184 287 VLEVSSEDAIKMARELALKEGLMVGISSGANTVAAIRLAKMPEnKGKLIVTIHASFGERYLS 348
Cdd:cd01561  231 VVRVSDEEAFAMARRLAREEGLLVGGSSGAAVAAALKLAKRLG-PGKTIVTILPDSGERYLS 291
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 54-339 3.62e-69

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 219.10  E-value: 3.62e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184   54 SLLIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNlitpGKTTLIEPTSGNMGISMAFMAAMK 133
Cdd:pfam00291   2 SLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGE----GGKTVVEASSGNHGRALAAAAARL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  134 GYKIIMTMPSYTSLERRVTMRSFGAELVLTDPtkGMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYdTTGPEIWEDT 213
Cdd:pfam00291  78 GLKVTIVVPEDAPPGKLLLMRALGAEVVLVGG--DYDEAVAAARELAAEGPGAYYINQYDNPLNIEGYG-TIGLEILEQL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  214 LGNVDIFVMGIGSGGTVSGVGQYLKFKNPNVKIYGVEPAESNILNGG---------KPGPHAITGNGVGFKPDILDMDVM 284
Cdd:pfam00291 155 GGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSlaagrpvpvPVADTIADGLGVGDEPGALALDLL 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  285 E----SVLEVSSEDAIKMARELALKEGLMVGISSGANtVAAIRLAKMPE-NKGKLIVTIH 339
Cdd:pfam00291 235 DeyvgEVVTVSDEEALEAMRLLARREGIVVEPSSAAA-LAALKLALAGElKGGDRVVVVL 293
 
Name Accession Description Interval E-value
PLN02556 PLN02556
cysteine synthase/L-3-cyanoalanine synthase
 1-368 0e+00

cysteine synthase/L-3-cyanoalanine synthase


Pssm-ID: 178171 [Multi-domain]  Cd Length: 368  Bit Score: 665.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184   1 MATIWRRLLKTETIPRISQSTRKLFSTDGSSSFAERLRNLPKEFPATQAKRDASLLIGRTPLVFLNRVTEGCGAYIAAKQ 80
Cdd:PLN02556   1 MAALLSRLKRRSSIPPSSHTLRKLFSTVGSPSFAQRLRDLPKDLPGTKIKTDASQLIGKTPLVYLNKVTEGCGAYIAAKQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  81 EHFQPTCSVKDRPALAMVADAEKKNLITPGKTTLIEPTSGNMGISMAFMAAMKGYKIIMTMPSYTSLERRVTMRSFGAEL 160
Cdd:PLN02556  81 EMFQPTSSIKDRPALAMIEDAEKKNLITPGKTTLIEPTSGNMGISLAFMAAMKGYKMILTMPSYTSLERRVTMRAFGAEL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 161 VLTDPTKGMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYDTTGPEIWEDTLGNVDIFVMGIGSGGTVSGVGQYLKFK 240
Cdd:PLN02556 161 VLTDPTKGMGGTVKKAYELLESTPDAFMLQQFSNPANTQVHFETTGPEIWEDTLGQVDIFVMGIGSGGTVSGVGKYLKSK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 241 NPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPDILDMDVMESVLEVSSEDAIKMARELALKEGLMVGISSGANTVA 320
Cdd:PLN02556 241 NPNVKIYGVEPAESNVLNGGKPGPHHITGNGVGFKPDILDMDVMEKVLEVSSEDAVNMARELALKEGLMVGISSGANTVA 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 922553184 321 AIRLAKMPENKGKLIVTIHASFGERYLSSILFDELRKEAEAMKPVSVD 368
Cdd:PLN02556 321 ALRLAKMPENKGKLIVTVHPSFGERYLSSVLFQELRKEAENMQPVSVD 368
PLN02565 PLN02565
cysteine synthase
 51-363 1.65e-154

cysteine synthase


Pssm-ID: 166206  Cd Length: 322  Bit Score: 437.43  E-value: 1.65e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  51 RDASLLIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLITPGKTTLIEPTSGNMGISMAFMA 130
Cdd:PLN02565   7 KDVTELIGKTPLVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIGYSMITDAEEKGLIKPGESVLIEPTSGNTGIGLAFMA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 131 AMKGYKIIMTMPSYTSLERRVTMRSFGAELVLTDPTKGMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYDTTGPEIW 210
Cdd:PLN02565  87 AAKGYKLIITMPASMSLERRIILLAFGAELVLTDPAKGMKGAVQKAEEILAKTPNSYILQQFENPANPKIHYETTGPEIW 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 211 EDTLGNVDIFVMGIGSGGTVSGVGQYLKFKNPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPDILDMDVMESVLEV 290
Cdd:PLN02565 167 KGTGGKVDAFVSGIGTGGTITGAGKYLKEQNPDIKLYGVEPVESAVLSGGKPGPHKIQGIGAGFIPGVLDVDLLDEVVQV 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922553184 291 SSEDAIKMARELALKEGLMVGISSGANTVAAIRLAKMPENKGKLIVTIHASFGERYLSSILFDELRKEAEAMK 363
Cdd:PLN02565 247 SSDEAIETAKLLALKEGLLVGISSGAAAAAAIKIAKRPENAGKLIVVIFPSFGERYLSSVLFESVKKEAENMV 319
cysK TIGR01139
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ...
 54-352 4.18e-144

cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273465  Cd Length: 298  Bit Score: 410.22  E-value: 4.18e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184   54 SLLIGRTPLVFLNRVtEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLITPGkTTLIEPTSGNMGISMAFMAAMK 133
Cdd:TIGR01139   2 SELIGNTPLVRLNRI-EGCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPG-KTIVEPTSGNTGIALAMVAAAR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  134 GYKIIMTMPSYTSLERRVTMRSFGAELVLTDPTKGMGGTVKKAYDLLESTPAAH-MLQQFANPANTQIHYDTTGPEIWED 212
Cdd:TIGR01139  80 GYKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSYfMLQQFENPANPEIHRKTTGPEIWRD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  213 TLGNVDIFVMGIGSGGTVSGVGQYLKFKNPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPDILDMDVMESVLEVSS 292
Cdd:TIGR01139 160 TDGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEVITVSD 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  293 EDAIKMARELALKEGLMVGISSGANTVAAIRLAKMPEnKGKLIVTIHASFGERYLSSILF 352
Cdd:TIGR01139 240 EEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPE-PDKLIVVILPSTGERYLSTPLF 298
cysKM TIGR01136
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ...
 54-352 4.11e-142

cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273463  Cd Length: 299  Bit Score: 405.13  E-value: 4.11e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184   54 SLLIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLITPGkTTLIEPTSGNMGISMAFMAAMK 133
Cdd:TIGR01136   2 EELIGNTPLVRLNRLAPGCDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPG-DTIIEATSGNTGIALAMVAAAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  134 GYKIIMTMPSYTSLERRVTMRSFGAELVLTDPTKGMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYDTTGPEIWEDT 213
Cdd:TIGR01136  81 GYKLILTMPETMSLERRKLLRAYGAELILTPGEEGMKGAIDKAEELAAETNKYVMLDQFENPANPEAHYKTTGPEIWRDT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  214 LGNVDIFVMGIGSGGTVSGVGQYLKFKNPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPDILDMDVMESVLEVSSE 293
Cdd:TIGR01136 161 DGRIDHFVAGVGTGGTITGVGRYLKEQNPNIQIVAVEPAESPVLSGGEPGPHKIQGIGAGFIPKILDLSLIDEVITVSDE 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 922553184  294 DAIKMARELALKEGLMVGISSGANTVAAIRLAKMPENKGKLIVTIHASFGERYLSSILF 352
Cdd:TIGR01136 241 DAIETARRLAREEGILVGISSGAAVAAALKLAKRLENADKVIVAILPDTGERYLSTGLF 299
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 56-349 9.83e-140

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 399.04  E-value: 9.83e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  56 LIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLITPGkTTLIEPTSGNMGISMAFMAAMKGY 135
Cdd:COG0031   10 LIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGLAMVAAAKGY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 136 KIIMTMPSYTSLERRVTMRSFGAELVLTDPTKGMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYDTTGPEIWEDTLG 215
Cdd:COG0031   89 RLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTGPEIWEQTDG 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 216 NVDIFV---------MGIgsggtvsgvGQYLKFKNPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPDILDMDVMES 286
Cdd:COG0031  169 KVDAFVagvgtggtiTGV---------GRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFVPKILDPSLIDE 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922553184 287 VLEVSSEDAIKMARELALKEGLMVGISSGANTVAAIRLAKMpENKGKLIVTIHASFGERYLSS 349
Cdd:COG0031  240 VITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKR-LGPGKTIVTILPDSGERYLST 301
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
 58-348 2.22e-137

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 392.65  E-value: 2.22e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  58 GRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLITPGkTTLIEPTSGNMGISMAFMAAMKGYKI 137
Cdd:cd01561    1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPG-TTIIEPTSGNTGIGLAMVAAAKGYRF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 138 IMTMPSYTSLERRVTMRSFGAELVLTDPTK--GMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYDTTGPEIWEDTLG 215
Cdd:cd01561   80 IIVMPETMSEEKRKLLRALGAEVILTPEAEadGMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 216 NVDIFV---------MGIgsggtvsgvGQYLKFKNPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPDILDMDVMES 286
Cdd:cd01561  160 KVDAFVagvgtggtiTGV---------ARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDE 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 922553184 287 VLEVSSEDAIKMARELALKEGLMVGISSGANTVAAIRLAKMPEnKGKLIVTIHASFGERYLS 348
Cdd:cd01561  231 VVRVSDEEAFAMARRLAREEGLLVGGSSGAAVAAALKLAKRLG-PGKTIVTILPDSGERYLS 291
PLN00011 PLN00011
cysteine synthase
 50-362 4.55e-134

cysteine synthase


Pssm-ID: 177651  Cd Length: 323  Bit Score: 385.51  E-value: 4.55e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  50 KRDASLLIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLITPGKTTLIEPTSGNMGISMAFM 129
Cdd:PLN00011   8 KNDVTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEATAGNTGIGLACI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 130 AAMKGYKIIMTMPSYTSLERRVTMRSFGAELVLTDPTKGMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYDTTGPEI 209
Cdd:PLN00011  88 GAARGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIPQQFENPANPEIHYRTTGPEI 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 210 WEDTLGNVDIFVMGIGSGGTVSGVGQYLKFKNPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPDILDMDVMESVLE 289
Cdd:PLN00011 168 WRDSAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESAVLSGGQPGPHLIQGIGSGIIPFNLDLTIVDEIIQ 247

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922553184 290 VSSEDAIKMARELALKEGLMVGISSGANTVAAIRLAKMPENKGKLIVTIHASFGERYLSSILFDELRKEAEAM 362
Cdd:PLN00011 248 VTGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVIFPSGGERYLSTKLFESVRYEAENL 320
PLN03013 PLN03013
cysteine synthase
 52-364 2.17e-132

cysteine synthase


Pssm-ID: 178587 [Multi-domain]  Cd Length: 429  Bit Score: 385.28  E-value: 2.17e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  52 DASLLIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLITPGKTTLIEPTSGNMGISMAFMAA 131
Cdd:PLN03013 116 NVSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGIGLAFIAA 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 132 MKGYKIIMTMPSYTSLERRVTMRSFGAELVLTDPTKGMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYDTTGPEIWE 211
Cdd:PLN03013 196 SRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAYMLQQFDNPANPKIHYETTGPEIWD 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 212 DTLGNVDIFVMGIGSGGTVSGVGQYLKFKNPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPDILDMDVMESVLEVS 291
Cdd:PLN03013 276 DTKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVEPTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIMDEVIAIS 355

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922553184 292 SEDAIKMARELALKEGLMVGISSGANTVAAIRLAKMPENKGKLIVTIHASFGeRYLSSILFDELRKEAEAMKP 364
Cdd:PLN03013 356 SEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENAGKLIAVSLFASG-RDIYTPRCSSLSGKRWRKCS 427
cysM PRK11761
cysteine synthase CysM;
56-354 5.43e-92

cysteine synthase CysM;


Pssm-ID: 236972  Cd Length: 296  Bit Score: 277.52  E-value: 5.43e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  56 LIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLITPGkTTLIEPTSGNMGISMAFMAAMKGY 135
Cdd:PRK11761   9 TIGNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKPG-DTLIEATSGNTGIALAMIAAIKGY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 136 KIIMTMPSYTSLERRVTMRSFGAELVLTDPTKGMGGtvkkAYDLLESTPAA---HMLQQFANPANTQIHYDTTGPEIWED 212
Cdd:PRK11761  88 RMKLIMPENMSQERRAAMRAYGAELILVPKEQGMEG----ARDLALQMQAEgegKVLDQFANPDNPLAHYETTGPEIWRQ 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 213 TLGNVDIFV---------MGIgsggtvsgvGQYLKFKNPNVKIYGVEPAE-SNIlnggkPG----PHAitgngvgFKPDI 278
Cdd:PRK11761 164 TEGRITHFVssmgttgtiMGV---------SRYLKEQNPAVQIVGLQPEEgSSI-----PGirrwPEE-------YLPKI 222

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 922553184 279 LDMDVMESVLEVSSEDAIKMARELALKEGLMVGISSGANTVAAIRLAKmpENKGKLIVTIHASFGERYLSSILFDE 354
Cdd:PRK11761 223 FDASRVDRVLDVSQQEAENTMRRLAREEGIFCGVSSGGAVAAALRIAR--ENPNAVIVAIICDRGDRYLSTGVFPA 296
PRK10717 PRK10717
cysteine synthase A; Provisional
 50-358 1.82e-86

cysteine synthase A; Provisional


Pssm-ID: 182672 [Multi-domain]  Cd Length: 330  Bit Score: 264.42  E-value: 1.82e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  50 KRDASLLIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLITPGKTtLIEPTSGNMGISMAFM 129
Cdd:PRK10717   4 FEDVSDTIGNTPLIRLNRASEATGCEILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGGT-IVEGTAGNTGIGLALV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 130 AAMKGYKIIMTMPSYTSLERRVTMRSFGAELVLT------DPTKGMGGTVKKAYDLLESTPA-AHMLQQFANPANTQIHY 202
Cdd:PRK10717  83 AAARGYKTVIVMPETQSQEKKDLLRALGAELVLVpaapyaNPNNYVKGAGRLAEELVASEPNgAIWANQFDNPANREAHY 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 203 DTTGPEIWEDTLGNVDIFVMGIGSGGTVSGVGQYLKFKNPNVKIYGVEPAESNI----LNG--GKPGPHAITGNGVGFKP 276
Cdd:PRK10717 163 ETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTGSALysyyKTGelKAEGSSITEGIGQGRIT 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 277 DILDMDVMESVLEVSSEDAIKMARELALKEGLMVGISSGANTVAAIRLAKmPENKGKLIVTIHASFGERYLSSILFDELR 356
Cdd:PRK10717 243 ANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLAR-ELGPGHTIVTILCDSGERYQSKLFNPDFL 321


                 ..
gi 922553184 357 KE 358
Cdd:PRK10717 322 RE 323
cysta_beta TIGR01137
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but ...
 56-354 9.72e-76

cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273464 [Multi-domain]  Cd Length: 455  Bit Score: 241.24  E-value: 9.72e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184   56 LIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLITPGkTTLIEPTSGNMGISMAFMAAMKGY 135
Cdd:TIGR01137   8 LIGNTPLVRLNKVSKGLKCELLAKCEFFNPGGSVKDRIALRMIEDAEASGRLKPG-DTIIEPTSGNTGIGLALVAAIKGY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  136 KIIMTMPSYTSLERRVTMRSFGAELVLTdPTKGM----GGTVKKAYDLLESTPAAHMLQQFANPANTQIHYDTTGPEIWE 211
Cdd:TIGR01137  87 KCIIVLPEKMSSEKVDVLRALGAEIVRT-PTAAAfdspESHIGVAKRLVREIPGAHILDQYRNPSNPLAHYDTTGPEILE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  212 DTLGNVDIFVMGIGSGGTVSGVGQYLKFKNPNVKIYGVEP-----AESNILNGGKPGPHAITGNGVGFKPDILDMDVMES 286
Cdd:TIGR01137 166 QCEGKLDMFVAGVGTGGTITGIARYLKESCPGCRIVGADPegsilAQPEELNQTGRTPYKVEGIGYDFIPTVLDRKVVDE 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 922553184  287 VLEVSSEDAIKMARELALKEGLMVGISSGANTVAAIRLAKMPENKGKLIVTIHASFGERYLSSILFDE 354
Cdd:TIGR01137 246 WIKTDDKESFTMARRLIKEEGLLVGGSSGSAVVAALKAAEDELQEGQRCVVLLPDSIRNYMTKFLNDE 313
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 54-339 3.62e-69

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 219.10  E-value: 3.62e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184   54 SLLIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNlitpGKTTLIEPTSGNMGISMAFMAAMK 133
Cdd:pfam00291   2 SLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGE----GGKTVVEASSGNHGRALAAAAARL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  134 GYKIIMTMPSYTSLERRVTMRSFGAELVLTDPtkGMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYdTTGPEIWEDT 213
Cdd:pfam00291  78 GLKVTIVVPEDAPPGKLLLMRALGAEVVLVGG--DYDEAVAAARELAAEGPGAYYINQYDNPLNIEGYG-TIGLEILEQL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  214 LGNVDIFVMGIGSGGTVSGVGQYLKFKNPNVKIYGVEPAESNILNGG---------KPGPHAITGNGVGFKPDILDMDVM 284
Cdd:pfam00291 155 GGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSlaagrpvpvPVADTIADGLGVGDEPGALALDLL 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  285 E----SVLEVSSEDAIKMARELALKEGLMVGISSGANtVAAIRLAKMPE-NKGKLIVTIH 339
Cdd:pfam00291 235 DeyvgEVVTVSDEEALEAMRLLARREGIVVEPSSAAA-LAALKLALAGElKGGDRVVVVL 293
Trp-synth-beta_II cd00640
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ...
 60-339 1.89e-64

Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.


Pssm-ID: 107202 [Multi-domain]  Cd Length: 244  Bit Score: 205.06  E-value: 1.89e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  60 TPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLItpGKTTLIEPTSGNMGISMAFMAAMKGYKIIM 139
Cdd:cd00640    1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKL--PKGVIIESTGGNTGIALAAAAARLGLKCTI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 140 TMPSYTSLERRVTMRSFGAELVLTDPtkGMGGTVKKAYDLLESTPAAHMLQQFANPANTQIHYdTTGPEIWEDTLG-NVD 218
Cdd:cd00640   79 VMPEGASPEKVAQMRALGAEVVLVPG--DFDDAIALAKELAEEDPGAYYVNQFDNPANIAGQG-TIGLEILEQLGGqKPD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 219 IFV---------MGIgsggtvsgvGQYLKFKNPNVKIYGVEPAesnilnggkpgphaitgngvgfkpdildmdvmesVLE 289
Cdd:cd00640  156 AVVvpvggggniAGI---------ARALKELLPNVKVIGVEPE----------------------------------VVT 192

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 922553184 290 VSSEDAIKMARELALKEGLMVGISSGANTVAAIRLAKmPENKGKLIVTIH 339
Cdd:cd00640  193 VSDEEALEAIRLLAREEGILVEPSSAAALAAALKLAK-KLGKGKTVVVIL 241
PLN02356 PLN02356
phosphateglycerate kinase
 30-348 1.99e-31

phosphateglycerate kinase


Pssm-ID: 215204  Cd Length: 423  Bit Score: 123.18  E-value: 1.99e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  30 SSSFAERL---RNLPKEFPATQAKRDASLLIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNL 106
Cdd:PLN02356  21 SYSFLLCNsrkRKTKKPLSKKKPRNGLIDAIGNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIEEALESGQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 107 ITPGKTtLIEPTSGNMGISMAFMAAMKGYKIIMTMPSYTSLERRVTMRSFGAELVLTDP--------------------- 165
Cdd:PLN02356 101 LFPGGV-VTEGSAGSTAISLATVAPAYGCKCHVVIPDDVAIEKSQILEALGATVERVRPvsithkdhyvniarrralean 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 166 --------TKGMGGT------------VKKAYDLLESTPAAHMLQQFANPANTQIHYDTTGPEIWEDTLGNVDIFVMGIG 225
Cdd:PLN02356 180 elaskrrkGSETDGIhlektngciseeEKENSLFSSSCTGGFFADQFENLANFRAHYEGTGPEIWEQTQGNLDAFVAAAG 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 226 SGGTVSGVGQYLKFKNPNVKIYGVEPAESNILNGGKPG---------------PHAITGNGVGFK--PDILDMDVMESVL 288
Cdd:PLN02356 260 TGGTLAGVSRFLQEKNPNIKCFLIDPPGSGLFNKVTRGvmytreeaegrrlknPFDTITEGIGINrlTQNFLMAKLDGAF 339

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 289 EVSSEDAIKMARELALKEGLMVGISSGANTVAAIRLAKmPENKGKLIVTIHASFGERYLS 348
Cdd:PLN02356 340 RGTDKEAVEMSRYLLKNDGLFVGSSSAMNCVGAVRVAQ-SLGPGHTIVTILCDSGMRHLS 398
IlvA COG1171
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ...
 59-338 2.06e-15

Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440784 [Multi-domain]  Cd Length: 327  Bit Score: 76.23  E-value: 2.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  59 RTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVA---DAEKKNlitpgktTLIEPTSGNMGISMAFMAAMKGY 135
Cdd:COG1171   24 RTPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALAslsEEERAR-------GVVAASAGNHAQGVAYAARLLGI 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 136 KIIMTMPSYTSLERRVTMRSFGAELVLTDPTkgmggtvkkaYDllESTPAAHMLQQfanpAN--TQIH-YD--------- 203
Cdd:COG1171   97 PATIVMPETAPAVKVAATRAYGAEVVLHGDT----------YD--DAEAAAAELAE----EEgaTFVHpFDdpdviagqg 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 204 TTGPEIWEDtLGNVD-IFV--------MGIGSggtvsgvgqYLKFKNPNVKIYGVEPAESN------------------- 255
Cdd:COG1171  161 TIALEILEQ-LPDLDaVFVpvggggliAGVAA---------ALKALSPDIRVIGVEPEGAAamyrslaagepvtlpgvdt 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 256 I---LNGGKPGPHAitgngvgFkpDILDMDVMESVLeVsSEDAIKMA-RELALKEGLMVGiSSGANTVAAIrLAKMPENK 331
Cdd:COG1171  231 IadgLAVGRPGELT-------F--EILRDLVDDIVT-V-SEDEIAAAmRLLLERTKIVVE-PAGAAALAAL-LAGKERLK 297


                 ....*..
gi 922553184 332 GKLIVTI 338
Cdd:COG1171  298 GKRVVVV 304
Thr-dehyd cd01562
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ...
 59-338 2.23e-15

Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.


Pssm-ID: 107205 [Multi-domain]  Cd Length: 304  Bit Score: 75.60  E-value: 2.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  59 RTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVA---DAEKKNLItpgkttlIEPTSGNMGISMAFMAAMKGY 135
Cdd:cd01562   17 RTPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLLslsEEERAKGV-------VAASAGNHAQGVAYAAKLLGI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 136 KIIMTMPSYTSLERRVTMRSFGAELVLTDPTkgmggtvkkaYDllESTPAAHMLQQ-----FANPANtqiHYD------T 204
Cdd:cd01562   90 PATIVMPETAPAAKVDATRAYGAEVVLYGED----------FD--EAEAKARELAEeegltFIHPFD---DPDviagqgT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 205 TGPEIWEDtLGNVD-IFV--------MGIGSggtvsgvgqYLKFKNPNVKIYGVEPAESNI----LNGGKPGPHAITGN- 270
Cdd:cd01562  155 IGLEILEQ-VPDLDaVFVpvggggliAGIAT---------AVKALSPNTKVIGVEPEGAPAmaqsLAAGKPVTLPEVDTi 224

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 922553184 271 --G-----VGFKPDILDMDVMESVLEVsSEDAIKMA-RELALKEGLMV-GisSGANTVAAIrLAKMPENKGKLIVTI 338
Cdd:cd01562  225 adGlavkrPGELTFEIIRKLVDDVVTV-SEDEIAAAmLLLFEREKLVAeP--AGALALAAL-LSGKLDLKGKKVVVV 297
ThrC COG0498
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ...
 12-164 5.06e-14

Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 440264 [Multi-domain]  Cd Length: 394  Bit Score: 72.54  E-value: 5.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  12 ETIPRISQSTrkLFSTDGSSSFAERLrnlpkefPATQAKRDASLLIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKD 91
Cdd:COG0498   28 DSYPALSRED--LASRRGLWRYRELL-------PFDDEEKAVSLGEGGTPLVKAPRLADELGKNLYVKEEGHNPTGSFKD 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 922553184  92 RpALAMVADAEKKNlitpGKTTLIEPTSGNMGISMAFMAAMKGYKIIMTMPS-YTSLERRVTMRSFGAELVLTD 164
Cdd:COG0498   99 R-AMQVAVSLALER----GAKTIVCASSGNGSAALAAYAARAGIEVFVFVPEgKVSPGQLAQMLTYGAHVIAVD 167
Thr-synth_1 cd01563
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ...
 42-161 6.73e-10

Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.


Pssm-ID: 107206 [Multi-domain]  Cd Length: 324  Bit Score: 59.53  E-value: 6.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  42 KEFPATQAKRDASLLIGRTPLVFLNRVTEGCGAY-IAAKQEHFQPTCSVKDRPALAMVADAekKNLitpGKTTLIEPTSG 120
Cdd:cd01563    5 RELLPVTEDDIVSLGEGNTPLVRAPRLGERLGGKnLYVKDEGLNPTGSFKDRGMTVAVSKA--KEL---GVKAVACASTG 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 922553184 121 NMGISMAFMAAMKGYKIIMTMPSYTSLERRVTMRSFGAELV 161
Cdd:cd01563   80 NTSASLAAYAARAGIKCVVFLPAGKALGKLAQALAYGATVL 120
PRK06815 PRK06815
threonine/serine dehydratase;
46-338 1.17e-09

threonine/serine dehydratase;


Pssm-ID: 180709 [Multi-domain]  Cd Length: 317  Bit Score: 58.94  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  46 ATQAKRDAsllIGRTPL---VFLNRVTeGCGAYIaaKQEHFQPTCSVKDRPA----LAMVADAEKKNLITPgkttliepT 118
Cdd:PRK06815  10 AHQRLRPQ---VRVTPLehsPLLSQHT-GCEVYL--KCEHLQHTGSFKFRGAsnklRLLNEAQRQQGVITA--------S 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 119 SGNMGISMAFMAAMKGYKIIMTMPSYTSLERRVTMRSFGAELVLTDPtkgmggtvkkayDLLESTPAAHMLQQ-----FA 193
Cdd:PRK06815  76 SGNHGQGVALAAKLAGIPVTVYAPEQASAIKLDAIRALGAEVRLYGG------------DALNAELAARRAAEqqgkvYI 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 194 NPANtqihyD--------TTGPEIWEDTLGNVDIFVM--------GIGSggtvsgvgqYLKFKNPNVKIYGVEPAESNI- 256
Cdd:PRK06815 144 SPYN-----DpqviagqgTIGMELVEQQPDLDAVFVAvgggglisGIAT---------YLKTLSPKTEIIGCWPANSPSl 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 257 ---LNGGKPGPHAIT-----GNGVGFKPDILDMDVMESVLEVS---SEDAIKMA-RELALKEGLMVGISSGANTVAAIRL 324
Cdd:PRK06815 210 ytsLEAGEIVEVAEQptlsdGTAGGVEPGAITFPLCQQLIDQKvlvSEEEIKEAmRLIAETDRWLIEGAAGVALAAALKL 289

                        330
                 ....*....|....
gi 922553184 325 AkmPENKGKLIVTI 338
Cdd:PRK06815 290 A--PRYQGKKVAVV 301
PRK12483 PRK12483
threonine dehydratase; Reviewed
 60-360 8.54e-08

threonine dehydratase; Reviewed


Pssm-ID: 237111 [Multi-domain]  Cd Length: 521  Bit Score: 53.65  E-value: 8.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  60 TPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVA----DAEKKNLITPgkttliepTSGNMGISMAFMAAMKGY 135
Cdd:PRK12483  38 TPLQRAPNLSARLGNQVLLKREDLQPVFSFKIRGAYNKMArlpaEQLARGVITA--------SAGNHAQGVALAAARLGV 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 136 KIIMTMPSYTSLERRVTMRSFGAELVLTdptkgmGGTVKKAYdllestpaAHMLQQFANPANTQIH-YD---------TT 205
Cdd:PRK12483 110 KAVIVMPRTTPQLKVDGVRAHGGEVVLH------GESFPDAL--------AHALKLAEEEGLTFVPpFDdpdviagqgTV 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 206 GPEIWEDTLGNVD-IFVmGIGSGGTVSGVGQYLKFKNPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPD------- 277
Cdd:PRK12483 176 AMEILRQHPGPLDaIFV-PVGGGGLIAGIAAYVKYVRPEIKVIGVEPDDSNCLQAALAAGERVVLGQVGLFADgvavaqi 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 278 -----ILDMDVMESVLEVSSeDAIKMARELALKEGLMVGISSGANTVAAI-RLAKMPENKGKLIVTIHASfgerylSSIL 351
Cdd:PRK12483 255 gehtfELCRHYVDEVVTVST-DELCAAIKDIYDDTRSITEPAGALAVAGIkKYAEREGIEGQTLVAIDSG------ANVN 327


                 ....*....
gi 922553184 352 FDELRKEAE 360
Cdd:PRK12483 328 FDRLRHVAE 336
PRK06381 PRK06381
threonine synthase; Validated
 79-164 9.60e-08

threonine synthase; Validated


Pssm-ID: 235789  Cd Length: 319  Bit Score: 53.17  E-value: 9.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  79 KQEHFQPTCSVKDRPALAMVADAekknlITPGKTTLIEPTSGNMGISMAFMAAMKGYKIIMTMPSYTSLERRVTMRSFGA 158
Cdd:PRK06381  36 KFEGANPTGTQKDRIAEAHVRRA-----MRLGYSGITVGTCGNYGASIAYFARLYGLKAVIFIPRSYSNSRVKEMEKYGA 110


                 ....*.
gi 922553184 159 ELVLTD 164
Cdd:PRK06381 111 EIIYVD 116
PRK05638 PRK05638
threonine synthase; Validated
 48-325 3.44e-06

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 48.65  E-value: 3.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  48 QAKRDASLLIGRTPLVfLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAekknlITPGKTTLIEPTSGNMGISMA 127
Cdd:PRK05638  55 QVKKIISLGEGGTPLI-RARISEKLGENVYIKDETRNPTGSFRDRLATVAVSYG-----LPYAANGFIVASDGNAAASVA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 128 FMAAMKGYKIIMTMPSYTSLERRVTMRSFGAELVLTdptkgmGGTVKKAYDLLESTPAAHMLQQfANPANTQIHYD---T 204
Cdd:PRK05638 129 AYSARAGKEAFVVVPRKVDKGKLIQMIAFGAKIIRY------GESVDEAIEYAEELARLNGLYN-VTPEYNIIGLEgqkT 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 205 TGPEIWEDtLGNVDIFVmgiGSGGTVSGVGQYLKFK---NPNV-----KIYGVE-----PAESNILnGGKPGPHAITGNG 271
Cdd:PRK05638 202 IAFELWEE-INPTHVIV---PTGSGSYLYSIYKGFKellEIGVieeipKLIAVQtercnPIASEIL-GNKTKCNETKALG 276

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 272 VGFKPDILDMDVMESVLE------VSSEDAIKMARELALKEGLMVGISSGANTVAAIRLA 325
Cdd:PRK05638 277 LYVKNPVMKEYVSEAIKEsggtavVVNEEEIMAGEKLLAKEGIFAELSSAVVMPALLKLG 336
PRK06110 PRK06110
threonine dehydratase;
73-161 3.51e-06

threonine dehydratase;


Pssm-ID: 235699  Cd Length: 322  Bit Score: 48.07  E-value: 3.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  73 GAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNlitPGKTTLIEPTSGNMGISMAFMAAMKGYKIIMTMPSYTSLERRVT 152
Cdd:PRK06110  35 GCEVWVKHENHTPTGAFKVRGGLVYFDRLARRG---PRVRGVISATRGNHGQSVAFAARRHGLAATIVVPHGNSVEKNAA 111


                 ....*....
gi 922553184 153 MRSFGAELV 161
Cdd:PRK06110 112 MRALGAELI 120
PLN02550 PLN02550
threonine dehydratase
 60-257 4.29e-06

threonine dehydratase


Pssm-ID: 178165 [Multi-domain]  Cd Length: 591  Bit Score: 48.38  E-value: 4.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  60 TPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLitpgKTTLIEPTSGNMGISMAFMAAMKGYKIIM 139
Cdd:PLN02550 110 SPLQLAKKLSERLGVKVLLKREDLQPVFSFKLRGAYNMMAKLPKEQL----DKGVICSSAGNHAQGVALSAQRLGCDAVI 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 140 TMPSYTSLERRVTMRSFGAELVLtdptkgmggtVKKAYDLLESTPAAHMLQQ-------FANPaNTQIHYDTTGPEIWED 212
Cdd:PLN02550 186 AMPVTTPEIKWQSVERLGATVVL----------VGDSYDEAQAYAKQRALEEgrtfippFDHP-DVIAGQGTVGMEIVRQ 254

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 922553184 213 TLGNVDIFVMGIGSGGTVSGVGQYLKFKNPNVKIYGVEPAESNIL 257
Cdd:PLN02550 255 HQGPLHAIFVPVGGGGLIAGIAAYVKRVRPEVKIIGVEPSDANAM 299
PRK06608 PRK06608
serine/threonine dehydratase;
48-164 5.64e-06

serine/threonine dehydratase;


Pssm-ID: 235842 [Multi-domain]  Cd Length: 338  Bit Score: 47.84  E-value: 5.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  48 QAKRDASLLIGRTPLV---FLNRVTegcGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKNLItPGKttLIEPTSGNMGI 124
Cdd:PRK06608  12 AAHNRIKQYLHLTPIVhseSLNEML---GHEIFFKVESLQKTGAFKVRGVLNHLLELKEQGKL-PDK--IVAYSTGNHGQ 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 922553184 125 SMAFMAAMKGYKIIMTMPSYTSLERRVTMRSFGAELVLTD 164
Cdd:PRK06608  86 AVAYASKLFGIKTRIYLPLNTSKVKQQAALYYGGEVILTN 125
PRK08638 PRK08638
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
57-250 7.85e-06

bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;


Pssm-ID: 236317 [Multi-domain]  Cd Length: 333  Bit Score: 47.04  E-value: 7.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  57 IGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPA---LAMVADAEKKNLItpgkttlIEPTSGNMGISMAFMAAMK 133
Cdd:PRK08638  25 IRKTPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGAfnkLSSLTDAEKRKGV-------VACSAGNHAQGVALSCALL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 134 GYKIIMTMPSYTSLERRVTMRSFGAELVLTDPTkgMGGTVKKAYDLLESTpaahmlqqfanpANTQIH-YD--------- 203
Cdd:PRK08638  98 GIDGKVVMPKGAPKSKVAATCGYGAEVVLHGDN--FNDTIAKVEEIVEEE------------GRTFIPpYDdpkviagqg 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 922553184 204 TTGPEIWEDtLGNVDIFVMGIGSGGTVSGVGQYLKFKNPNVKIYGVE 250
Cdd:PRK08638 164 TIGLEILED-LWDVDTVIVPIGGGGLIAGIAVALKSINPTIHIIGVQ 209
PRK06450 PRK06450
threonine synthase; Validated
 39-337 2.02e-05

threonine synthase; Validated


Pssm-ID: 180565 [Multi-domain]  Cd Length: 338  Bit Score: 45.88  E-value: 2.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  39 NLPKEFPatQAKRDASLLIGRTPLVFLNRVTegcgayiaAKQEHFQPTCSVKDRPALAMVAdaekkNLITPGKTTLIEPT 118
Cdd:PRK06450  40 LERKNFP--YIKHFISLGEGRTPLIKKGNIW--------FKLDFLNPTGSYKDRGSVTLIS-----YLAEKGIKQISEDS 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 119 SGNMGISMAFMAAMKGYKIIMTMPSYTSLERRVTMRSFGAELVltdPTKGMGGTVKKAYDLLESTPAAHMLQ-QFANPAN 197
Cdd:PRK06450 105 SGNAGASIAAYGAAAGIEVKIFVPETASGGKLKQIESYGAEVV---RVRGSREDVAKAAENSGYYYASHVLQpQFRDGIR 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 198 TqIHYdttgpEIWEDTLGNV--DIFV--------MGIgsggtvsgvgqYLKFKN----------PN---VKIYGVEPAES 254
Cdd:PRK06450 182 T-LAY-----EIAKDLDWKIpnYVFIpvsagtllLGV-----------YSGFKHlldsgvisemPKivaVQTEQVSPLCA 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 255 NiLNGGKPGPHA----ITGNGVGFKPDILDMdvMESVL------EVSSEDAIKMAR-ELALKeGLMVGISSgANTVAAIR 323
Cdd:PRK06450 245 K-FKGISYTPPDkvtsIADALVSTRPFLLDY--MVKALseygecIVVSDNEIVEAWkELAKK-GLLVEYSS-ATVYAAYK 319

                        330
                 ....*....|....
gi 922553184 324 laKMPENKGKLIVT 337
Cdd:PRK06450 320 --KYSVNDSVLVLT 331
PRK08197 PRK08197
threonine synthase; Validated
 54-164 3.11e-05

threonine synthase; Validated


Pssm-ID: 181283 [Multi-domain]  Cd Length: 394  Bit Score: 45.38  E-value: 3.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  54 SLLIGRTPLVFLNRVTEGCGA---YIaaKQEHFQPTCSVKDRPALAMVADAekKNLitpGKTTLIEPTSGNMGISMAFMA 130
Cdd:PRK08197  74 SLGEGMTPLLPLPRLGKALGIgrlWV--KDEGLNPTGSFKARGLAVGVSRA--KEL---GVKHLAMPTNGNAGAAWAAYA 146

                         90       100       110
                 ....*....|....*....|....*....|....
gi 922553184 131 AMKGYKIIMTMPSYTSLERRVTMRSFGAELVLTD 164
Cdd:PRK08197 147 ARAGIRATIFMPADAPEITRLECALAGAELYLVD 180
PRK08329 PRK08329
threonine synthase; Validated
 79-160 1.97e-04

threonine synthase; Validated


Pssm-ID: 236244 [Multi-domain]  Cd Length: 347  Bit Score: 42.89  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  79 KQEHFQPTCSVKDRPALAMVAdaekkNLITPGKTTLIEPTSGNMGISMAFMAAMKGYKIIMTMPSYTSLERRVTMRSFGA 158
Cdd:PRK08329  77 KLDYLQPTGSFKDRGTYVTVA-----KLKEEGINEVVIDSSGNAALSLALYSLSEGIKVHVFVSYNASKEKISLLSRLGA 151


                 ..
gi 922553184 159 EL 160
Cdd:PRK08329 152 EL 153
PBP1_As_SBP-like cd06330
periplasmic substrate-binding domain of active transport proteins; Periplasmic ...
 291-341 3.26e-04

periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea that is predicted to be involved in the efflux of toxic compounds. Members of this subgroup include proteins from Herminiimonas arsenicoxydans, which is resistant to arsenic (As) and various heavy metals such as cadmium and zinc. Moreover, they show significant sequence similarity to the cluster of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa.


Pssm-ID: 380553 [Multi-domain]  Cd Length: 342  Bit Score: 42.16  E-value: 3.26e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 922553184 291 SSEDAIKMARELALKEG--LMVGISSGANTVAAIRLAKmpENKGKLIVTIHAS 341
Cdd:cd06330   51 KPDEAVRAARELVLQEGvdFLIGTISSGVALAVAPVAE--ELKVLFIATDAAT 101
PRK13803 PRK13803
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional
 58-336 5.63e-04

bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 237513 [Multi-domain]  Cd Length: 610  Bit Score: 41.72  E-value: 5.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  58 GR-TPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPALAMVADAEKKnlitpGKTTLIEPT-SGNMGISMAFMAAMKGY 135
Cdd:PRK13803 269 GRpTPLTEAKRLSDIYGARIYLKREDLNHTGSHKINNALGQALLAKRM-----GKTRIIAETgAGQHGVATATACALFGL 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 136 KIIMTMPS------YTSLERrvtMRSFGAELVltdPTKGMGGTVKKA---------------YDLLESTPAAH----MLQ 190
Cdd:PRK13803 344 KCTIFMGEedikrqALNVER---MKLLGANVI---PVLSGSKTLKDAvneairdwvasvpdtHYLIGSAVGPHpypeMVA 417

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 191 QF----ANPANTQIHYDTTG-PEIWEDTLG---NvdifVMGIGsggtvsgvgqYLKFKNPNVKIYGVEPAESNILNG--- 259
Cdd:PRK13803 418 YFqsviGEEAKEQLKEQTGKlPDAIIACVGggsN----AIGIF----------YHFLDDPSVKLIGVEAGGKGVNTGeha 483

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 260 -----GKPG-------------------PHAITGN----GVGFKPDILDMDVMESVLEVSSEDAIKMARELALKEGLMVG 311
Cdd:PRK13803 484 atikkGRKGvlhgsmtylmqdengqilePHSISAGldypGIGPMHANLFETGRAIYTSVTDEEALDAFKLLAKLEGIIPA 563

                        330       340
                 ....*....|....*....|....*
gi 922553184 312 ISSgANTVAAIRLAKMPENKGKLIV 336
Cdd:PRK13803 564 LES-SHALAYLKEGRKKFKKKDIVI 587
PRK08639 PRK08639
threonine dehydratase; Validated
 46-252 2.31e-03

threonine dehydratase; Validated


Pssm-ID: 236318 [Multi-domain]  Cd Length: 420  Bit Score: 39.79  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  46 ATQAKRDaslLIGRTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDRPA---LAMVADAEKKNLITPgkttliePTSGNM 122
Cdd:PRK08639  15 AAKRLKD---VVPETPLQRNDYLSEKYGANVYLKREDLQPVRSYKLRGAynaISQLSDEELAAGVVC-------ASAGNH 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184 123 GISMAFMAAMKGYKIIMTMPSYTSLERRVTMRSFGA---ELVLTdptkgmGGT----VKKAYDLLESTpAAHMLQQFANP 195
Cdd:PRK08639  85 AQGVAYACRHLGIPGVIFMPVTTPQQKIDQVRFFGGefvEIVLV------GDTfddsAAAAQEYAEET-GATFIPPFDDP 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 922553184 196 aNTQIHYDTTGPEIWED--TLGNVDIFVMGIGSGGTVSGVGQYLKFKNPNVKIYGVEPA 252
Cdd:PRK08639 158 -DVIAGQGTVAVEILEQleKEGSPDYVFVPVGGGGLISGVTTYLKERSPKTKIIGVEPA 215
PRK07048 PRK07048
threo-3-hydroxy-L-aspartate ammonia-lyase;
59-167 3.95e-03

threo-3-hydroxy-L-aspartate ammonia-lyase;


Pssm-ID: 235918 [Multi-domain]  Cd Length: 321  Bit Score: 38.85  E-value: 3.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922553184  59 RTPLVFLNRVTEGCGAYIAAKQEHFQPTCSVKDR---PALAMVADAEKKNlitpGKTTLiepTSGNMGISMAFMAAMKGY 135
Cdd:PRK07048  24 RTPVLTSRTADARTGAQVFFKCENFQRMGAFKFRgayNALSQFSPEQRRA----GVVTF---SSGNHAQAIALSARLLGI 96

                         90       100       110
                 ....*....|....*....|....*....|..
gi 922553184 136 KIIMTMPSYTSLERRVTMRSFGAELVLTDPTK 167
Cdd:PRK07048  97 PATIVMPQDAPAAKVAATRGYGGEVVTYDRYT 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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