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Conserved domains on  [gi|861419136|ref|XP_012925053|]
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protein tilB homolog isoform X1 [Heterocephalus glaber]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-216 1.21e-20

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 90.62  E-value: 1.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136  78 LEELSLHQQEIERLEHIDKwCRDLKILYLQNNLIGKIENVSKLKKLE------------------------------YLN 127
Cdd:cd21340   48 LTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVLN 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136 128 LALNNIEKIENLEGCEVLTKLDLTVNFIGELSSVK-SLTHNIHLKELFLMGNPCADFDGYRQFVVATLQQLKWLDGKEID 206
Cdd:cd21340  127 ISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEIT 206

                        170
                 ....*....|
gi 861419136 207 RSERiQALQN 216
Cdd:cd21340  207 DTER-QFLKR 215
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-216 1.21e-20

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 90.62  E-value: 1.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136  78 LEELSLHQQEIERLEHIDKwCRDLKILYLQNNLIGKIENVSKLKKLE------------------------------YLN 127
Cdd:cd21340   48 LTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVLN 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136 128 LALNNIEKIENLEGCEVLTKLDLTVNFIGELSSVK-SLTHNIHLKELFLMGNPCADFDGYRQFVVATLQQLKWLDGKEID 206
Cdd:cd21340  127 ISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEIT 206

                        170
                 ....*....|
gi 861419136 207 RSERiQALQN 216
Cdd:cd21340  207 DTER-QFLKR 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-201 1.06e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136  77 SLEELSLHQQEIERL-EHIDKwCRDLKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIEKI-ENLEGCEVLTKLDLTVN 153
Cdd:COG4886  114 NLESLDLSGNQLTDLpEELAN-LTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNN 192

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 861419136 154 FIGELSsvKSLTHNIHLKELFLMGNPCADFDGyrqfVVATLQQLKWLD 201
Cdd:COG4886  193 QITDLP--EPLGNLTNLEELDLSGNQLTDLPE----PLANLTNLETLD 234
LRR_9 pfam14580
Leucine-rich repeat;
58-215 1.26e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.38  E-value: 1.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136   58 RVTEDLIRRNAEHNDCVifSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI- 136
Cdd:pfam14580   3 KLTAELIEQSAQYTNPV--RERELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136  137 ENL-EGCEVLTKLDLTVNFIGELSSVKSLTHNIHLKELFLMGNPCADFDGYRQFVVATLQQLKWLDGKEIDRSERIQALQ 215
Cdd:pfam14580  81 EGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-216 1.21e-20

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 90.62  E-value: 1.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136  78 LEELSLHQQEIERLEHIDKwCRDLKILYLQNNLIGKIENVSKLKKLE------------------------------YLN 127
Cdd:cd21340   48 LTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVLN 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136 128 LALNNIEKIENLEGCEVLTKLDLTVNFIGELSSVK-SLTHNIHLKELFLMGNPCADFDGYRQFVVATLQQLKWLDGKEID 206
Cdd:cd21340  127 ISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEIT 206

                        170
                 ....*....|
gi 861419136 207 RSERiQALQN 216
Cdd:cd21340  207 DTER-QFLKR 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-201 1.06e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136  77 SLEELSLHQQEIERL-EHIDKwCRDLKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIEKI-ENLEGCEVLTKLDLTVN 153
Cdd:COG4886  114 NLESLDLSGNQLTDLpEELAN-LTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNN 192

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 861419136 154 FIGELSsvKSLTHNIHLKELFLMGNPCADFDGyrqfVVATLQQLKWLD 201
Cdd:COG4886  193 QITDLP--EPLGNLTNLEELDLSGNQLTDLPE----PLANLTNLETLD 234
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-224 7.53e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 7.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136  77 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEVLTKLDLTVNFIG 156
Cdd:COG4886  206 NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 861419136 157 ELsSVKSLTHNIHLKELFLMGNPCADFDGYRQFVVATLQQLKWLDGKEIDRSERIQALQNYSVIEQQI 224
Cdd:COG4886  286 DL-KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352
LRR_9 pfam14580
Leucine-rich repeat;
58-215 1.26e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.38  E-value: 1.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136   58 RVTEDLIRRNAEHNDCVifSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI- 136
Cdd:pfam14580   3 KLTAELIEQSAQYTNPV--RERELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136  137 ENL-EGCEVLTKLDLTVNFIGELSSVKSLTHNIHLKELFLMGNPCADFDGYRQFVVATLQQLKWLDGKEIDRSERIQALQ 215
Cdd:pfam14580  81 EGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 101-141 3.95e-07

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 46.47  E-value: 3.95e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 861419136  101 LKILYLQNNLIGKIENVSKLKKLEYLNLALNN-IEKIENLEG 141
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLAN 44
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-201 6.32e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 6.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136  33 SPGQLEASLRSQCCLESKQWRPVNSRVTEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKwCRDLKILYLQNNlig 112
Cdd:COG4886   31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD-LTNLTELDLSGN--- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136 113 kiENVSKLKKLEYLNLALNNIEKI-ENLEGCEVLTKLDLTVNFIGELSSvkSLTHNIHLKELFLMGNPCADFDGyrqfVV 191
Cdd:COG4886  107 --EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDLPE----EL 178

                        170
                 ....*....|
gi 861419136 192 ATLQQLKWLD 201
Cdd:COG4886  179 GNLTNLKELD 188
LRR_8 pfam13855
Leucine rich repeat;
101-153 1.24e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 861419136  101 LKILYLQNNLIGKIENVS--KLKKLEYLNLALNNIEKIEN--LEGCEVLTKLDLTVN 153
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 121-163 5.19e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 5.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 861419136  121 KKLEYLNLALNNIEKIENLEGCEVLTKLDLT-VNFIGELSSVKS 163
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
77-133 9.68e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 9.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 861419136   77 SLEELSLHQQEIERLEhiDKW---CRDLKILYLQNNLIGKIENVS--KLKKLEYLNLALNNI 133
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD--DGAfkgLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 104-182 3.49e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.77  E-value: 3.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136 104 LYLQNNLIGK------IENVSKLKKLEYLNLALNNI------EKIENLEGCEVLTKLDLTVNFIGE---LSSVKSLTHNI 168
Cdd:COG5238  269 LYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIgdegaiALAEGLQGNKTLHTLNLAYNGIGAqgaIALAKALQENT 348

                         90
                 ....*....|....
gi 861419136 169 HLKELFLMGNPCAD 182
Cdd:COG5238  349 TLHSLDLSDNQIGD 362
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 77-178 3.75e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.77  E-value: 3.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136  77 SLEELSLHQQEIERLEHIDkwcrdlkilyLQNNLIGK------IENVSKLKKLEYLNLALNNIEK------IENLEGCEV 144
Cdd:COG5238  224 GAEILAEALKGNKSLTTLD----------LSNNQIGDegvialAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTT 293

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 861419136 145 LTKLDLTVNFIGELSSV---KSLTHNIHLKELFLMGN 178
Cdd:COG5238  294 LTSLDLSVNRIGDEGAIalaEGLQGNKTLHTLNLAYN 330
LRR_8 pfam13855
Leucine rich repeat;
122-179 9.70e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 9.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 861419136  122 KLEYLNLALNNIEKI--ENLEGCEVLTKLDLTVNFIGELSSvKSLTHNIHLKELFLMGNP 179
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNR 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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