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Conserved domains on  [gi|847172687|ref|XP_012809573|]
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isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform X4 [Xenopus tropicalis]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
20-353 0e+00

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR00175:

Pssm-ID: 444908  Cd Length: 333  Bit Score: 516.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687   20 GAFHVTMIPGDGVGPELMHSVREVFKAADVPVEFDEHHLSEVQNMASkEKLDEVLASMQANKVAIKGKIHTPMEyKGELA 99
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKT-EIPDEAVESIKRNKVALKGPLETPIG-KGGHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  100 SYEMRLRRKLDLFANVVHVNSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESVSGVIECLKIITREKSNRIAKFAFDYAT 179
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  180 KKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 259
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  260 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSATNMLRHLNLEYHSNLISDAVKKVIKQGKVRTRDMGGY 339
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 847172687  340 STTTDFIKAVIDGL 353
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 20-353 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 516.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687   20 GAFHVTMIPGDGVGPELMHSVREVFKAADVPVEFDEHHLSEVQNMASkEKLDEVLASMQANKVAIKGKIHTPMEyKGELA 99
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKT-EIPDEAVESIKRNKVALKGPLETPIG-KGGHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  100 SYEMRLRRKLDLFANVVHVNSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESVSGVIECLKIITREKSNRIAKFAFDYAT 179
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  180 KKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 259
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  260 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSATNMLRHLNLEYHSNLISDAVKKVIKQGKVRTRDMGGY 339
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 847172687  340 STTTDFIKAVIDGL 353
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 2-353 7.27e-138

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 396.16  E-value: 7.27e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687   2 AALRHFLRSTQAEPGKSDGAFH-VTMIPGDGVGPELMHSVREVFKAADVPVEFDEHhlsEVQNmASKEKLDEVLASMQAN 80
Cdd:PLN00123  10 LGSKAQRRSVTYMPRPGDGAPRaVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERY---EVHG-DMKKVPEEVLESIRRN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  81 KVAIKGKIHTPMeyKGELASYEMRLRRKLDLFANVVHVNSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESVSGVIECLK 160
Cdd:PLN00123  86 KVCLKGGLATPV--GGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 161 IITREKSNRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVL 240
Cdd:PLN00123 164 VITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVM 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 241 VMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARH---PFAQAVGRNIANPTAMLLSATNMLRHLNLEYHSNL 317
Cdd:PLN00123 244 VTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAgnvGNEKLVEQKKANPVALLLSSAMMLRHLQFPSFADR 323

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 847172687 318 ISDAVKKVIKQGKVRTRDMGGYSTTTDFIKAVIDGL 353
Cdd:PLN00123 324 LETAVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANL 359
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 22-351 5.88e-114

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 334.67  E-value: 5.88e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  22 FHVTMIPGDGVGPELMHSVREVFKAA----DVPVEFDEHHLSEVQNMASKEKL-DEVLASMQANKVAIKGKIHTPmEYKG 96
Cdd:COG0473    2 YKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIGGAAYDKTGTPLpDETLEALRKADAILLGAVGGP-KWDD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  97 ELaSYE---MRLRRKLDLFANVVHVNSLPGYKTRH-----NNLDLVIIREQTEGEYSSLEHESVSG----VIECLKIITR 164
Cdd:COG0473   81 GV-RPEsglLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVYTR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 165 EKSNRIAKFAFDYAtKKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVLVMPN 244
Cdd:COG0473  160 KGIERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 245 LYGNIIDNLAAGLVGGAGVVPGESYSAEY-AVFEtgARH---PfaQAVGRNIANPTAMLLSATNMLRHLNLEYHSNLISD 320
Cdd:COG0473  239 LFGDILSDLAAGLTGSLGLAPSANIGDEGkALFE--PVHgsaP--DIAGKGIANPIATILSAAMMLRHLGEEEAADAIEA 314

                        330       340       350
                 ....*....|....*....|....*....|.
gi 847172687 321 AVKKVIKQGkVRTRDMGGYSTTTDFIKAVID 351
Cdd:COG0473  315 AVEKVLAEG-VRTPDLGGKAGTSEMGDAIIA 344
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
23-349 5.09e-96

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 289.19  E-value: 5.09e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687   23 HVTMIPGDGVGPELMHSVREVFKAAD--VPVEFD--EHHLSEVQNMASKEKL-DEVLASMQANKVAIKGKIHTPMEYKGE 97
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALekAPLEFEfeERDVGGAAIDETGEPLpDETLEACKKADAVLLGAVGGPKWDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687   98 LASYE--MRLRRKLDLFANVVHVNSLPG------YKTRHNNLDLVIIREQTEGEYSSLEHESVSGVIEC---LKIITREK 166
Cdd:pfam00180  81 VRPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGIKGSGNEVavdTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  167 SNRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVLVMPNLY 246
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  247 GNIIDNLAAGLVGGAGVVPGESYSA-EYAVFEtgARHPFAQAV-GRNIANPTAMLLSATNMLRH-LNLEYHSNLISDAVK 323
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGAnGFGIFE--PVHGSAPDIaGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVL 318

                         330       340
                  ....*....|....*....|....*....
gi 847172687  324 KVIKQGKvRTRDMGG---YSTTTDFIKAV 349
Cdd:pfam00180 319 KVLESGI-RTGDLAGsatYVSTSEFGEAV 346
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 20-353 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 516.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687   20 GAFHVTMIPGDGVGPELMHSVREVFKAADVPVEFDEHHLSEVQNMASkEKLDEVLASMQANKVAIKGKIHTPMEyKGELA 99
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKT-EIPDEAVESIKRNKVALKGPLETPIG-KGGHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  100 SYEMRLRRKLDLFANVVHVNSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESVSGVIECLKIITREKSNRIAKFAFDYAT 179
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  180 KKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 259
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  260 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSATNMLRHLNLEYHSNLISDAVKKVIKQGKVRTRDMGGY 339
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 847172687  340 STTTDFIKAVIDGL 353
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 2-353 7.27e-138

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 396.16  E-value: 7.27e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687   2 AALRHFLRSTQAEPGKSDGAFH-VTMIPGDGVGPELMHSVREVFKAADVPVEFDEHhlsEVQNmASKEKLDEVLASMQAN 80
Cdd:PLN00123  10 LGSKAQRRSVTYMPRPGDGAPRaVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERY---EVHG-DMKKVPEEVLESIRRN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  81 KVAIKGKIHTPMeyKGELASYEMRLRRKLDLFANVVHVNSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESVSGVIECLK 160
Cdd:PLN00123  86 KVCLKGGLATPV--GGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 161 IITREKSNRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVL 240
Cdd:PLN00123 164 VITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVM 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 241 VMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARH---PFAQAVGRNIANPTAMLLSATNMLRHLNLEYHSNL 317
Cdd:PLN00123 244 VTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAgnvGNEKLVEQKKANPVALLLSSAMMLRHLQFPSFADR 323

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 847172687 318 ISDAVKKVIKQGKVRTRDMGGYSTTTDFIKAVIDGL 353
Cdd:PLN00123 324 LETAVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANL 359
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 8-353 3.45e-134

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 387.31  E-value: 3.45e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687   8 LRSTQAEPGKSDGAFHVTMIPGDGVGPELMHSVREVFKAADVPVEFDEHHLSE-----VQNMASKEKLDEVLAsmqaNKV 82
Cdd:PLN00118  28 FSSSARAFSSSSTPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTtvdprTGSFLTWESLESVRR----NKV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  83 AIKGKIHTPMEyKGElASYEMRLRRKLDLFANVVHVNSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESVSGVIECLKII 162
Cdd:PLN00118 104 GLKGPMATPIG-KGH-RSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKII 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 163 TREKSNRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVLVM 242
Cdd:PLN00118 182 TRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVM 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 243 PNLYGNIIDNLAAGLVGGAGVVP-GESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSATNMLRHLNLEYHSNLISD 320
Cdd:PLN00118 262 PNLYGDIISDLCAGLIGGLGLTPsCNIGENGLALAE--AVHGSAPDIaGKNLANPTALLLSAVMMLRHLKLNEQAEQIHN 339

                        330       340       350
                 ....*....|....*....|....*....|...
gi 847172687 321 AVKKVIKQGKVRTRDMGGYSTTTDFIKAVIDGL 353
Cdd:PLN00118 340 AILNTIAEGKYRTADLGGSSTTTDFTKAICDHL 372
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 22-351 5.88e-114

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 334.67  E-value: 5.88e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  22 FHVTMIPGDGVGPELMHSVREVFKAA----DVPVEFDEHHLSEVQNMASKEKL-DEVLASMQANKVAIKGKIHTPmEYKG 96
Cdd:COG0473    2 YKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIGGAAYDKTGTPLpDETLEALRKADAILLGAVGGP-KWDD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  97 ELaSYE---MRLRRKLDLFANVVHVNSLPGYKTRH-----NNLDLVIIREQTEGEYSSLEHESVSG----VIECLKIITR 164
Cdd:COG0473   81 GV-RPEsglLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVYTR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 165 EKSNRIAKFAFDYAtKKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVLVMPN 244
Cdd:COG0473  160 KGIERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 245 LYGNIIDNLAAGLVGGAGVVPGESYSAEY-AVFEtgARH---PfaQAVGRNIANPTAMLLSATNMLRHLNLEYHSNLISD 320
Cdd:COG0473  239 LFGDILSDLAAGLTGSLGLAPSANIGDEGkALFE--PVHgsaP--DIAGKGIANPIATILSAAMMLRHLGEEEAADAIEA 314

                        330       340       350
                 ....*....|....*....|....*....|.
gi 847172687 321 AVKKVIKQGkVRTRDMGGYSTTTDFIKAVID 351
Cdd:COG0473  315 AVEKVLAEG-VRTPDLGGKAGTSEMGDAIIA 344
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 24-353 3.28e-108

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 319.74  E-value: 3.28e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  24 VTMIPGDGVGPELMHSVREVFKAADVPVEFDEHHLSEVQNMASKEKL-DEVLASMQANKVAIKGKIHTPMeykGE-LASY 101
Cdd:PRK08997   5 ITVIPGDGIGPSIIDATLKILDKLGCDFEYEFADAGLTALEKHGELLpQRTLDLIEKNKIALKGPLTTPV---GEgFTSI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 102 EMRLRRKLDLFANVVHVNSLPGYKTRHNNLDLVIIREQTEGEYSSLEHE-SVSG-VIECLKIITREKSNRIAKFAFDYAT 179
Cdd:PRK08997  82 NVTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTvSEDGeTAEATSIITRKGAERIVRFAYELAR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 180 KKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 259
Cdd:PRK08997 162 KEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 260 GAGVVPGESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSATNMLRHLNLEYHSNLISDAVKKVIKQGKVRTRDMGG 338
Cdd:PRK08997 242 GLGMAPGANIGRDAAIFE--AVHGSAPDIaGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRDLGG 319

                        330
                 ....*....|....*
gi 847172687 339 YSTTTDFIKAVIDGL 353
Cdd:PRK08997 320 THGTTDFTQAVIDRL 334
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
23-349 5.09e-96

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 289.19  E-value: 5.09e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687   23 HVTMIPGDGVGPELMHSVREVFKAAD--VPVEFD--EHHLSEVQNMASKEKL-DEVLASMQANKVAIKGKIHTPMEYKGE 97
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALekAPLEFEfeERDVGGAAIDETGEPLpDETLEACKKADAVLLGAVGGPKWDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687   98 LASYE--MRLRRKLDLFANVVHVNSLPG------YKTRHNNLDLVIIREQTEGEYSSLEHESVSGVIEC---LKIITREK 166
Cdd:pfam00180  81 VRPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGIKGSGNEVavdTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  167 SNRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVLVMPNLY 246
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  247 GNIIDNLAAGLVGGAGVVPGESYSA-EYAVFEtgARHPFAQAV-GRNIANPTAMLLSATNMLRH-LNLEYHSNLISDAVK 323
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGAnGFGIFE--PVHGSAPDIaGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVL 318

                         330       340
                  ....*....|....*....|....*....
gi 847172687  324 KVIKQGKvRTRDMGG---YSTTTDFIKAV 349
Cdd:pfam00180 319 KVLESGI-RTGDLAGsatYVSTSEFGEAV 346
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
24-353 3.23e-94

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 289.10  E-value: 3.23e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  24 VTMIPGDGVGPELMHSVREVFKAADVPVEFDE----------HHLSEVQnmaskeklDEVLASMQANKVAIKGKIHTPME 93
Cdd:PRK09222   7 ITVAYGDGIGPEIMEAVLKILEAAGAPLEIETieigekvykkGWTSGIS--------PSAWESIRRTKVLLKAPITTPQG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  94 --YKgelaSYEMRLRRKLDLFANVVHVNSL-PGYKTRHNNLDLVIIREQTEGEYSSLEHESVSGVIECLKIITREKSNRI 170
Cdd:PRK09222  79 ggYK----SLNVTLRKTLGLYANVRPCVSYhPFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEKI 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 171 AKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVLVMPNLYGNII 250
Cdd:PRK09222 155 IRYAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDIL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 251 DNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSATNMLRHLNLEYHSNLISDAVKKVIKQG 329
Cdd:PRK09222 235 SDIAAEISGSVGLAGSANIGEEYAMFE--AVHGSAPDIaGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTLEDG 312

                        330       340       350
                 ....*....|....*....|....*....|
gi 847172687 330 kVRTRDMGGYST------TTDFIKAVIDGL 353
Cdd:PRK09222 313 -IHTADIYNEGVskkkvgTKEFAEAVIENL 341
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 24-350 1.93e-83

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 256.60  E-value: 1.93e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  24 VTMIPGDGVGPELMHSVREVFKAADVPVEFDEHHL-SEVQNMASKEKLDEVLASMQANKVAIKGKIhtpmeykGELA-SY 101
Cdd:PRK14025   4 ICVIEGDGIGKEVVPAALHVLEATGLPFEFVYAEAgDEVFEKTGKALPEETIEAAKEADAVLFGAA-------GETAaDV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 102 EMRLRRKLDLFANVVHVNSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESVSGVIECLKIITREKSNRIAKFAFDYATKK 181
Cdd:PRK14025  77 IVKLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFAFEMAKRR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 182 ----GRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGL 257
Cdd:PRK14025 157 kkmgKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 258 VGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANPTAMLLSATNMLRHLNLEYHSNLISDAVKKVIKQGKVrTRDM 336
Cdd:PRK14025 237 VGGLGLAPSANIGDKYGLFE--PVHGSApDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGLT-TPDL 313

                        330
                 ....*....|....
gi 847172687 337 GGYSTTTDFIKAVI 350
Cdd:PRK14025 314 GGNLSTMEMAEEVA 327
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 22-353 3.55e-59

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 194.93  E-value: 3.55e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  22 FHVTMIPGDGVGPELMHSVREVFKAA----DVPVEFDEHHLS-----EVQNMASKEKLDevlASMQANKV---AIKGK-- 87
Cdd:PRK00772   3 YKIAVLPGDGIGPEVMAEAVKVLDAVaekfGFDFEFEEALVGgaaidAHGVPLPEETLE---ACRAADAVllgAVGGPkw 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  88 IHTPME---YKGELAsyemrLRRKLDLFANV----VH---VNSLPGYKTRHNNLDLVIIREQTEGEYS------SLEHES 151
Cdd:PRK00772  80 DNLPPDvrpERGLLA-----LRKELGLFANLrpakLYpglADASPLKPEIVAGLDILIVRELTGGIYFgeprgrEGLGGE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 152 VSGVIEClkIITREKSNRIAKFAFDYAtKKGRSKVTAVHKANIMKlGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLV 231
Cdd:PRK00772 155 ERAFDTM--VYTREEIERIARVAFELA-RKRRKKVTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLV 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 232 QNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAE-YAVFETGarHPFA-QAVGRNIANPTAMLLSATNMLRH- 308
Cdd:PRK00772 231 RNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEPI--HGSApDIAGKGIANPIATILSAAMMLRYs 308

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 847172687 309 LNLEYHSNLISDAVKKVIKQGkVRTRDM---GGYSTTTDFIKAVIDGL 353
Cdd:PRK00772 309 LGLEEAADAIEAAVEKVLAQG-YRTADIaegGGKVSTSEMGDAILAAL 355
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 23-353 4.51e-53

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 178.75  E-value: 4.51e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687   23 HVTMIPGDGVGPELMHSVREVFKAAD----VPVEFDEHHLSEVQNMASKEKLDE--VLASMQANKV---AIKGK--IHTP 91
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAerfgLKFEFEEHLIGGAAIDATGQPLPEetLKGCKEADAVllgAVGGPkwDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687   92 MEYKGELASyeMRLRRKLDLFANVVHVNSLPGY-------KTRHNNLDLVIIREQTEGEYSSLEHE-SVSGVIECLKIIT 163
Cdd:TIGR00169  81 RDQRPEQGL--LKLRKSLDLFANLRPAKVFPGLedlsplkEEIAKGVDFVVVRELTGGIYFGEPKGrEGEGEAWDTEVYT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  164 REKSNRIAKFAFDYATKKgRSKVTAVHKANIMKLGDgLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVLVMP 243
Cdd:TIGR00169 159 VPEIERIARVAFEMARKR-RKKVTSVDKANVLESSR-LWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  244 NLYGNIIDNLAAGLVGGAGVVPGESYSAE-YAVFE-TGARHPfaQAVGRNIANPTAMLLSATNMLRH-LNLEYHSNLISD 320
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDgFGLFEpVHGSAP--DIAGKGIANPIAQILSAAMLLRYsFNLEEAADAIEA 314

                         330       340       350
                  ....*....|....*....|....*....|...
gi 847172687  321 AVKKVIKQGKvRTRDMGGYSTTTDFIKAVIDGL 353
Cdd:TIGR00169 315 AVKKVLAEGY-RTPDLGSSATTAVGTAEMGEEL 346
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 22-342 3.91e-46

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 160.48  E-value: 3.91e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  22 FHVTMIPGDGVGPELMHSVREVFKAA---DVPVEFDEHHLSEVQNMASKEKL-DEVLASMQANKVAIKGKIHTP------ 91
Cdd:PRK03437   5 MKLAVIPGDGIGPEVVAEALKVLDAVaagGPGVETTEYDLGARRYLRTGETLpDSVLAELRQHDAILLGAIGDPsvpsgv 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  92 MEyKGELasyeMRLRRKLDLFANVVHVNSLPGYKTRHNN---LDLVIIREQTEGEYSS--------LEHESVSGVieclK 160
Cdd:PRK03437  85 LE-RGLL----LKLRFALDHYVNLRPSKLYPGVTSPLAGpgdIDFVVVREGTEGPYTGnggalrvgTPHEVATEV----S 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 161 IITREKSNRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQLYPKIQFDTMIIDNCCMQLVQNPYQFDVL 240
Cdd:PRK03437 156 VNTAFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 241 VMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYA---VFET--GARHPFAqavGRNIANPTAMLLSATNMLRHLNLEYHS 315
Cdd:PRK03437 236 VTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTnpsMFEPvhGSAPDIA---GQGIADPTAAILSVALLLDHLGEEDAA 312

                        330       340
                 ....*....|....*....|....*..
gi 847172687 316 NLISDAVKKVikqgkVRTRDMGGYSTT 342
Cdd:PRK03437 313 ARIEAAVEAD-----LAERGKMGRSTA 334
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
27-351 9.29e-44

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 155.76  E-value: 9.29e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  27 IPGDGVGPELMHSVREVFKAAdvpvefdehhlSEVQNMASKE-KLDEVLASMQANK------------------VAIKGK 87
Cdd:PRK06451  29 VEGDGIGPEITHAAMKVINKA-----------VEKAYGSDREiKWVEVLAGDKAEKltgnrfpkeseeliekyrVLLKGP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  88 IHTPMEyKGeLASYEMRLRRKLDLFANVVHVNSLPGYKT--RH-NNLDLVIIREQTEGEYSSLEH--------------- 149
Cdd:PRK06451  98 LETPIG-KG-WKSINVAIRLMLDLYANIRPVKYIPGIESplKNpEKIDLIIFRENTDDLYRGIEYpydseeakkirdflr 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 150 -------ESVSGVieCLKIITREKSNRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCKEVA------------ 210
Cdd:PRK06451 176 kelgvevEDDTGI--GIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAYEVAlkefrdyvvtee 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 211 ---QLYP------KIQFDTMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgAR 281
Cdd:PRK06451 254 evtKNYNgvppsgKVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFE--AI 331

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 847172687 282 HPFA-QAVGRNIANPTAMLLSATNMLRHLNLEYHSNLISDAVKKVIKQGKVrTRDMGGYS-----TTTDFIKAVID 351
Cdd:PRK06451 332 HGTApKYAGKNVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKV-TQDLARFMgvralSTTEYTDELIS 406
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 22-356 1.87e-41

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 148.33  E-value: 1.87e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  22 FHVTMIPGDGVGPELMHSVREVFKA-ADV----PVEFDEHHLS-----EVQNMASKEKLdEVLASMQA---NKVAIKGKI 88
Cdd:PRK08194   4 FKIAVIPGDGVGKEVVPAAVRVLKAvAEVhgglKFEFTEFPWSceyylEHGEMMPEDGL-EQLKQFDAiflGAVGNPKLV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  89 HTPMEYKGELasyeMRLRRKLDLFANVVHVNSLPGYK---TRHNNLDLVIIREQTEGEYSSL-------EHESVsgVIEC 158
Cdd:PRK08194  83 PDHISLWGLL----IKIRREFEQVINIRPAKQLRGIKsplANPKDFDLLVVRENSEGEYSEVggrihrgEDEIA--IQNA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 159 lkIITREKSNRIAKFAFDYATKKgRSKVTAVHKAN----IMKLGDGLFlqccKEVAQLYPKIQFDTMIIDNCCMQLVQNP 234
Cdd:PRK08194 157 --VFTRKGTERAMRYAFELAAKR-RKHVTSATKSNgivhSMPFWDEVF----QEVGKDYPEIETDSQHIDALAAFFVTRP 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 235 YQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAE--Y-AVFEtgARHPFA-QAVGRNIANPTAMLLSATNMLRHLN 310
Cdd:PRK08194 230 EEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNgkYpSMFE--PVHGSApDIAGKGIANPIGQIWTAKLMLDHFG 307

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 847172687 311 LEYHSNLISDAVKKVIKQGkVRTRDMGGYSTTTDFIKAVIDGLHYR 356
Cdd:PRK08194 308 EEELGSHLLDVIEDVTEDG-IKTPDIGGRATTDEVTDEIISRLKKL 352
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 18-354 3.33e-41

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 149.11  E-value: 3.33e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  18 SDGAFHVTMIP------GDGVGPELMHSVREVFKAAdvpVEFdehhlsevqnmASKEKLD----EVLASMQANK------ 81
Cdd:COG0538    9 EDGKLKVPDNPiipfieGDGIGPEITRAIWKVIDAA---VEK-----------AYGGKRDiewkEVDAGEKARDetgdwl 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  82 ------------VAIKGKIHTPMEyKGelasyeMR-----LRRKLDLFAN---VVHVNSLPGYKTRHNNLDLVIIREQTE 141
Cdd:COG0538   75 pdetaeaikeygVGIKGPLTTPVG-GG------WRslnvtIRQILDLYVCrrpVRYFKGVPSPVKHPEKVDIVIFRENTE 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 142 GEYSSLE-------------------------HESVSGVIecLKIITREKSNRIAKFAFDYATKKGRSKVTAVHKANIMK 196
Cdd:COG0538  148 DIYAGIEwkagspealkliffledemgvtvirFPEDSGIG--IKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMK 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 197 LGDGLFLQCCKEVAQ-----------LYPKIQ----------FDTmIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAA 255
Cdd:COG0538  226 FTEGAFKDWGYEVAEeefgdkfitegPWEKYKgpkpagkivyKDR-IADDMLQQILLRPGEYDVIATKNLNGDYISDALA 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 256 GLVGGAGVVPGE--SYSAeYAVFE----TGARHpfaqaVGRNIANPTAMLLSATNMLRHLNLEYHSNLISDAVKKVIKQG 329
Cdd:COG0538  305 AQVGGLGIAPGAniGDDG-GAEFEathgTAPKY-----AGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESG 378

                        410       420       430
                 ....*....|....*....|....*....|.
gi 847172687 330 KVrTRD----MGG--YSTTTDFIKAVIDGLH 354
Cdd:COG0538  379 KV-TYDlarlMEGatELSTSEFGDAIIENLD 408
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 27-353 3.79e-35

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 132.88  E-value: 3.79e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  27 IPGDGVGPELMHSVREVFKAA-------DVPVEFDEHHLSEVQNMASKEKL---DEVLASMQANKVAIKGKIHTPMeyKG 96
Cdd:PRK07006  25 IEGDGIGPDITPAMLKVVDAAvekaykgERKISWMEIYAGEKATKVYGEDVwlpEETLDLIREYRVAIKGPLTTPV--GG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  97 ELASYEMRLRRKLDLFA---NVVHVNSLPGYKTRHNNLDLVIIREQTEGEYSSLEHES----VSGVIECL---------- 159
Cdd:PRK07006 103 GIRSLNVALRQELDLYVclrPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKAgsaeAKKVIKFLqeemgvkkir 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 160 ---------KIITREKSNRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCKEVAQ------LYPKIQFDTM--- 221
Cdd:PRK07006 183 fpetsgigiKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEeefgdeLIDGGPWDKIknp 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 222 -----------IIDNCCMQLVQNPYQFDVLVMPNLYGNII-DNLAAGlVGGAGVVPGESYSAEYAVFEtgARHPFA-QAV 288
Cdd:PRK07006 263 etgkeiivkdsIADAFLQQILLRPAEYDVIATMNLNGDYIsDALAAQ-VGGIGIAPGANINDGHAIFE--ATHGTApKYA 339

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 847172687 289 GRNIANPTAMLLSATNMLRHLNLEYHSNLISDAVKKVIKQgKVRTRD----MGGYS--TTTDFIKAVIDGL 353
Cdd:PRK07006 340 GLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIAS-KTVTYDfarlMEGATevKCSEFGDALIKNM 409
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 8-336 2.80e-28

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 114.01  E-value: 2.80e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687   8 LRSTQAEPGKSdgAFHVTMIPGDGVGPELMHSVREVFKAADV--PVEFDEHHL---SEVQNMASKEKLDEVLASMQANKV 82
Cdd:PLN02329  35 IRCAAASPGKK--RYNIALLPGDGIGPEVISVAKNVLQKAGSleGLEFDFQEMpvgGAALDLVGVPLPEETFTAAKQSDA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  83 AIKGKIHTpmeYKGELASYEMR-------LRRKLDLFANVVHVNSLPGY-------KTRHNNLDLVIIREQTEGEYSSLE 148
Cdd:PLN02329 113 ILLGAIGG---YKWDKNEKHLRpemalfyLRRDLKVFANLRPATVLPQLvdastlkKEVAEGVDMMIVRELTGGIYFGEP 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 149 -----HESVSGVIECLKIITREKSNRIAKFAFDYATKKgRSKVTAVHKANIMKlGDGLFLQCCKEVAQLYPKIQFDTMII 223
Cdd:PLN02329 190 rgitiNENGEEVGVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYV 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 224 DNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSAT 303
Cdd:PLN02329 268 DNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAA 347

                        330       340       350
                 ....*....|....*....|....*....|....
gi 847172687 304 NMLRH-LNLEYHSNLISDAVKKVIKQGkVRTRDM 336
Cdd:PLN02329 348 MLLKYgLGEEKAAKRIEDAVVDALNKG-FRTGDI 380
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
24-336 5.45e-19

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 87.85  E-value: 5.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  24 VTMIPGDGVGPELMHSVREVFKAADVPVEFDEHHLSEVQNMASKEKLD----------EVLASMQANKVAIKGKIHTPMe 93
Cdd:PRK07362  31 IPFIRGDGTGVDIWPATQKVLDAAVAKAYGGERKINWFKVYAGDEACDlygtyqylpeDTLEAIREYGVAIKGPLTTPI- 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687  94 yKGELASYEMRLRRKLDLFANVVHVNSLPGYKTRHNN---LDLVIIREQTEGEYSSLEHESVSGV----IECL------- 159
Cdd:PRK07362 110 -GGGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHKNpekLDVIVYRENTEDIYMGIEWEAGDEIgdklIKHLneevipa 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 160 -----------------KIITREKSNRIAKFAFDYATK--KGRSKVTAVHKANIMKLGDGLF------------------ 202
Cdd:PRK07362 189 spelgkrqiplgsgigiKPVSKTGSQRHIRRAIEHALRlpGDKRHVTLVHKGNIMKYTEGAFrdwgyelattefrdecvt 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 203 -------------------------------------LQCCKEV-------------AQLYPKIQFDTMIIDNCCMQLVQ 232
Cdd:PRK07362 269 ereswilsnkeknpnisiednarmiepgydsltpekkAAICAEVkevldsiwsshgnGKWKEKVLVDDRIADSIFQQIQT 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847172687 233 NPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANPTAMLLSATNMLRHLNL 311
Cdd:PRK07362 349 RPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFE--ATHGTApKHAGLDRINPGSVILSGVMMLEYLGW 426

                        410       420
                 ....*....|....*....|....*
gi 847172687 312 EYHSNLISDAVKKVIKQGKVrTRDM 336
Cdd:PRK07362 427 QEAADLITKGLSAAIANKQV-TYDL 450
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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