|
Name |
Accession |
Description |
Interval |
E-value |
| Glyco_transf_24 super family |
cl39742 |
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein ... |
1231-1390 |
2.71e-114 |
|
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
The actual alignment was detected with superfamily member pfam18404:
Pssm-ID: 436473 Cd Length: 268 Bit Score: 360.01 E-value: 2.71e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1231 NIFSVASGHLYERFLRIMMLSVLRNTKTPVKFWFLKNYLSPAFKEIIPYMAKEYGFQYELVQYKWPHWLHQQTEKQRIIW 1310
Cdd:pfam18404 2 NIFSVASGHLYERFLKIMMLSVRKNTKSPVKFWFIENFLSPSFKAFLPHLAKEYGFEYELVTYKWPSWLRKQTEKQRIIW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1311 GYKILFLDVLFPLSVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCDSRREMDGYRFWKTGYWASHLIRRKYHIRA 1390
Cdd:pfam18404 82 GYKILFLDVLFPLDLDKVIFVDADQVVRTDLKELVDMDLEGAPYGYTPMCDSRKEMEGFRFWKQGYWKDHLRGRPYHISA 161
|
|
| Thioredoxin_12 |
pfam18400 |
Thioredoxin-like domain; This is one of four TRXL(thioredoxin-like) domains found in ... |
45-226 |
1.09e-69 |
|
Thioredoxin-like domain; This is one of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
:
Pssm-ID: 465748 Cd Length: 187 Bit Score: 231.74 E-value: 1.09e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 45 ETPLLLEASEFMAEESNEKFWQFLGTVQELAIY-KQTESDYSYYNLILKKAGQFLDNLHINLLKFALSLRAYSPAIHMFQ 123
Cdd:pfam18400 1 ATPLLLEALETLAEENPDLFFPFLDALTNLDGEfADASTDEELYEAALKLASDHLSPLALSLFKLALSLRSASPRIEAFY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 124 QIAAD----EPPPDGCNAFVVIHKKHTCKINEIKKLLKK-ATSRPRPYLFKVDHKFPTNKEnLPVIILYAEMGTRAFSAF 198
Cdd:pfam18400 81 QIYAEsvsfEGAPPECDSWVDWGGEVYCDPEDLDALLKSeASSRPQPELLPFDHVYPDSGS-SPVAILYADLGSPNFREF 159
|
170 180
....*....|....*....|....*...
gi 829791201 199 HKVLSEKAQNGEILYVLRHYIQKPSSRK 226
Cdd:pfam18400 160 HKYLSELAKDGKIRYVLRHVPPSGSESK 187
|
|
| Thioredoxin_14 |
pfam18402 |
Thioredoxin-like domain; This is the third out of four TRXL(thioredoxin-like) domains found in ... |
437-685 |
2.10e-62 |
|
Thioredoxin-like domain; This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
:
Pssm-ID: 465750 Cd Length: 248 Bit Score: 213.29 E-value: 2.10e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 437 LDIRHS-----SIMWINDLENDGMYVTWPTSCQELLKPVFPGSIPTIRRNFHNLVLFIDPAQ-EYTLDFFKLAELFYFHK 510
Cdd:pfam18402 1 FDIRDRiegggVIIWLNDLEKDKRYSRWPSSLQELLRPTYPGQLPPIRKNLFNLVLVVDLSQpEDLLLLVETLQSFVQRG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 511 VPLRIGFVFILNTDDEvdgaddaGVALWRAFNYITEESDESEAFISVVH-MYQKLKAQSILTVDNVKNVLQNKFPHASIW 589
Cdd:pfam18402 81 IPVRFGLVPLVNSTED-------GLAQAKLFYYLLENYGLKAALSFLTAsLYALAKKVLSPTKAIFSSALKERTLRPQAL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 590 DILGI--HSKFDKERKAGASFYKMTGLGPL--PQALyNGEPFSHEEmnikELEMAVLQRMMAASIYLQKDVFMGTLNDRT 665
Cdd:pfam18402 154 SFDEVlkSEVYDERLKKAKEYLKRLGLDSLsgPVFV-NGVPLPRDE----NWLQALSQRISEDLQLLQKAVYEGALTDDD 228
|
250 260
....*....|....*....|
gi 829791201 666 NAIDFLMDRKNVVPRINSLI 685
Cdd:pfam18402 229 DVPDFFYDLPNALPRRNPLI 248
|
|
| Thioredoxin_15 |
pfam18403 |
Thioredoxin-like domain; This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose: ... |
709-932 |
5.99e-60 |
|
Thioredoxin-like domain; This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
:
Pssm-ID: 465751 Cd Length: 205 Bit Score: 204.77 E-value: 5.99e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 709 TFFFLDSQdkSAVIAKNMHYLTEKDDnVISAVTVWIIADFDKPSGRKLLFNALKHMRTSVHSRLGVIYNPTSKiNEENTA 788
Cdd:pfam18403 1 DLNKLYSE--HADLFDKMPYLEASSD-KEDWATLWVVADLDSESGRKLLLSALEFRKSNPGVRLGIIHNPASP-SEASSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 789 ISRGILAAFLTQKNSFLGSLLRKLAKEETATAIYSGdkiktfftegmdkntfeKKYNTIGVNIFRTHQLFCQdVLKLRPG 868
Cdd:pfam18403 77 ISSALLAALLKLKNLDALEFLTKLLEEEEAAASESG-----------------KSSAEAAADYWKALQPFLR-VLGLKPG 138
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 829791201 869 EMGIVSNGRFLGPLDKD--FYAEDFYLLEKITFSNSLEKIKGIVENMDINSK-NMSDLVMKVDALVS 932
Cdd:pfam18403 139 QNALVLNGRVVGPIPEDeeFSADDFELLLSYERSKRIEPVYKAIEELGLEDKiSDPDAVAKLTSLVA 205
|
|
| UDP-g_GGTase |
pfam06427 |
UDP-glucose:Glycoprotein Glucosyltransferase; This domain consists of 7 stranded ... |
1093-1198 |
1.39e-50 |
|
UDP-glucose:Glycoprotein Glucosyltransferase; This domain consists of 7 stranded beta-sandwiches found in UDP-glucose-glycoprotein glucosyltransferase-like proteins. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER.
:
Pssm-ID: 461910 Cd Length: 109 Bit Score: 173.83 E-value: 1.39e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1093 GYCFDTMTGQTPRGLQFTLGTKNKPVVVDTIVMAKLGYFQLKANPGAWILKLRKGKSEDIYQI--VGHEGPDSQPDlEDV 1170
Cdd:pfam06427 2 GHARDVTTGSPPRGLQLVLGTEKNPHVADTIVMANLGYFQLKANPGVWKLELREGRSSDIYEIesVGAEGWPSPGD-EGT 80
|
90 100
....*....|....*....|....*...
gi 829791201 1171 IVVLNSFKSKTLQVQVQKKPDKIKEDIL 1198
Cdd:pfam06427 81 EVALTSFEGLTLYPRLSRKPGMENEDVL 108
|
|
| Thioredoxin_13 |
pfam18401 |
Thioredoxin-like domain; This is the second out of four TRXL(thioredoxin-like) domains found ... |
296-424 |
3.44e-45 |
|
Thioredoxin-like domain; This is the second out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
:
Pssm-ID: 465749 Cd Length: 136 Bit Score: 159.66 E-value: 3.44e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 296 ESNKEMMPLKVWELQDLSFQAASQIMSTPvyDAIKLMKDISQNFPIKARSLTRIAVNQHMREEIQENQKDLqdgfeIQPG 375
Cdd:pfam18401 1 EEVEDLKPLSVWELQDLGLQAAQFIMSSD--DPLDTLLKLSQDFPKYASSLARHNVSDELREEIEENQERL-----LPPG 73
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 829791201 376 DARLFINGLRIDIDVYDPFSILDMLKLEGKMMNGLRNLGINEEDTSKFL 424
Cdd:pfam18401 74 DNALWLNGLQLDERDIDPFSLLDILRRERKLINGLRKLGLSGSEAVDLL 122
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Glyco_transf_24 |
pfam18404 |
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein ... |
1231-1390 |
2.71e-114 |
|
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
Pssm-ID: 436473 Cd Length: 268 Bit Score: 360.01 E-value: 2.71e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1231 NIFSVASGHLYERFLRIMMLSVLRNTKTPVKFWFLKNYLSPAFKEIIPYMAKEYGFQYELVQYKWPHWLHQQTEKQRIIW 1310
Cdd:pfam18404 2 NIFSVASGHLYERFLKIMMLSVRKNTKSPVKFWFIENFLSPSFKAFLPHLAKEYGFEYELVTYKWPSWLRKQTEKQRIIW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1311 GYKILFLDVLFPLSVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCDSRREMDGYRFWKTGYWASHLIRRKYHIRA 1390
Cdd:pfam18404 82 GYKILFLDVLFPLDLDKVIFVDADQVVRTDLKELVDMDLEGAPYGYTPMCDSRKEMEGFRFWKQGYWKDHLRGRPYHISA 161
|
|
| GT8_HUGT1_C_like |
cd06432 |
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain ... |
1230-1390 |
3.90e-111 |
|
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
Pssm-ID: 133054 Cd Length: 248 Bit Score: 350.54 E-value: 3.90e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1230 LNIFSVASGHLYERFLRIMMLSVLRNTKTPVKFWFLKNYLSPAFKEIIPYMAKEYGFQYELVQYKWPHWLHQQTEKQRII 1309
Cdd:cd06432 1 INIFSVASGHLYERFLRIMMLSVMKNTKSPVKFWFIKNFLSPQFKEFLPEMAKEYGFEYELVTYKWPRWLHKQTEKQRII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1310 WGYKILFLDVLFPLSVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCDSRREMDGYRFWKTGYWASHLIRRKYHIR 1389
Cdd:cd06432 81 WGYKILFLDVLFPLNVDKVIFVDADQIVRTDLKELMDMDLKGAPYGYTPFCDSRKEMDGFRFWKQGYWKSHLRGRPYHIS 160
|
.
gi 829791201 1390 A 1390
Cdd:cd06432 161 A 161
|
|
| Thioredoxin_12 |
pfam18400 |
Thioredoxin-like domain; This is one of four TRXL(thioredoxin-like) domains found in ... |
45-226 |
1.09e-69 |
|
Thioredoxin-like domain; This is one of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465748 Cd Length: 187 Bit Score: 231.74 E-value: 1.09e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 45 ETPLLLEASEFMAEESNEKFWQFLGTVQELAIY-KQTESDYSYYNLILKKAGQFLDNLHINLLKFALSLRAYSPAIHMFQ 123
Cdd:pfam18400 1 ATPLLLEALETLAEENPDLFFPFLDALTNLDGEfADASTDEELYEAALKLASDHLSPLALSLFKLALSLRSASPRIEAFY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 124 QIAAD----EPPPDGCNAFVVIHKKHTCKINEIKKLLKK-ATSRPRPYLFKVDHKFPTNKEnLPVIILYAEMGTRAFSAF 198
Cdd:pfam18400 81 QIYAEsvsfEGAPPECDSWVDWGGEVYCDPEDLDALLKSeASSRPQPELLPFDHVYPDSGS-SPVAILYADLGSPNFREF 159
|
170 180
....*....|....*....|....*...
gi 829791201 199 HKVLSEKAQNGEILYVLRHYIQKPSSRK 226
Cdd:pfam18400 160 HKYLSELAKDGKIRYVLRHVPPSGSESK 187
|
|
| Thioredoxin_14 |
pfam18402 |
Thioredoxin-like domain; This is the third out of four TRXL(thioredoxin-like) domains found in ... |
437-685 |
2.10e-62 |
|
Thioredoxin-like domain; This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465750 Cd Length: 248 Bit Score: 213.29 E-value: 2.10e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 437 LDIRHS-----SIMWINDLENDGMYVTWPTSCQELLKPVFPGSIPTIRRNFHNLVLFIDPAQ-EYTLDFFKLAELFYFHK 510
Cdd:pfam18402 1 FDIRDRiegggVIIWLNDLEKDKRYSRWPSSLQELLRPTYPGQLPPIRKNLFNLVLVVDLSQpEDLLLLVETLQSFVQRG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 511 VPLRIGFVFILNTDDEvdgaddaGVALWRAFNYITEESDESEAFISVVH-MYQKLKAQSILTVDNVKNVLQNKFPHASIW 589
Cdd:pfam18402 81 IPVRFGLVPLVNSTED-------GLAQAKLFYYLLENYGLKAALSFLTAsLYALAKKVLSPTKAIFSSALKERTLRPQAL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 590 DILGI--HSKFDKERKAGASFYKMTGLGPL--PQALyNGEPFSHEEmnikELEMAVLQRMMAASIYLQKDVFMGTLNDRT 665
Cdd:pfam18402 154 SFDEVlkSEVYDERLKKAKEYLKRLGLDSLsgPVFV-NGVPLPRDE----NWLQALSQRISEDLQLLQKAVYEGALTDDD 228
|
250 260
....*....|....*....|
gi 829791201 666 NAIDFLMDRKNVVPRINSLI 685
Cdd:pfam18402 229 DVPDFFYDLPNALPRRNPLI 248
|
|
| Thioredoxin_15 |
pfam18403 |
Thioredoxin-like domain; This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose: ... |
709-932 |
5.99e-60 |
|
Thioredoxin-like domain; This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465751 Cd Length: 205 Bit Score: 204.77 E-value: 5.99e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 709 TFFFLDSQdkSAVIAKNMHYLTEKDDnVISAVTVWIIADFDKPSGRKLLFNALKHMRTSVHSRLGVIYNPTSKiNEENTA 788
Cdd:pfam18403 1 DLNKLYSE--HADLFDKMPYLEASSD-KEDWATLWVVADLDSESGRKLLLSALEFRKSNPGVRLGIIHNPASP-SEASSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 789 ISRGILAAFLTQKNSFLGSLLRKLAKEETATAIYSGdkiktfftegmdkntfeKKYNTIGVNIFRTHQLFCQdVLKLRPG 868
Cdd:pfam18403 77 ISSALLAALLKLKNLDALEFLTKLLEEEEAAASESG-----------------KSSAEAAADYWKALQPFLR-VLGLKPG 138
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 829791201 869 EMGIVSNGRFLGPLDKD--FYAEDFYLLEKITFSNSLEKIKGIVENMDINSK-NMSDLVMKVDALVS 932
Cdd:pfam18403 139 QNALVLNGRVVGPIPEDeeFSADDFELLLSYERSKRIEPVYKAIEELGLEDKiSDPDAVAKLTSLVA 205
|
|
| UDP-g_GGTase |
pfam06427 |
UDP-glucose:Glycoprotein Glucosyltransferase; This domain consists of 7 stranded ... |
1093-1198 |
1.39e-50 |
|
UDP-glucose:Glycoprotein Glucosyltransferase; This domain consists of 7 stranded beta-sandwiches found in UDP-glucose-glycoprotein glucosyltransferase-like proteins. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER.
Pssm-ID: 461910 Cd Length: 109 Bit Score: 173.83 E-value: 1.39e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1093 GYCFDTMTGQTPRGLQFTLGTKNKPVVVDTIVMAKLGYFQLKANPGAWILKLRKGKSEDIYQI--VGHEGPDSQPDlEDV 1170
Cdd:pfam06427 2 GHARDVTTGSPPRGLQLVLGTEKNPHVADTIVMANLGYFQLKANPGVWKLELREGRSSDIYEIesVGAEGWPSPGD-EGT 80
|
90 100
....*....|....*....|....*...
gi 829791201 1171 IVVLNSFKSKTLQVQVQKKPDKIKEDIL 1198
Cdd:pfam06427 81 EVALTSFEGLTLYPRLSRKPGMENEDVL 108
|
|
| Thioredoxin_13 |
pfam18401 |
Thioredoxin-like domain; This is the second out of four TRXL(thioredoxin-like) domains found ... |
296-424 |
3.44e-45 |
|
Thioredoxin-like domain; This is the second out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465749 Cd Length: 136 Bit Score: 159.66 E-value: 3.44e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 296 ESNKEMMPLKVWELQDLSFQAASQIMSTPvyDAIKLMKDISQNFPIKARSLTRIAVNQHMREEIQENQKDLqdgfeIQPG 375
Cdd:pfam18401 1 EEVEDLKPLSVWELQDLGLQAAQFIMSSD--DPLDTLLKLSQDFPKYASSLARHNVSDELREEIEENQERL-----LPPG 73
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 829791201 376 DARLFINGLRIDIDVYDPFSILDMLKLEGKMMNGLRNLGINEEDTSKFL 424
Cdd:pfam18401 74 DNALWLNGLQLDERDIDPFSLLDILRRERKLINGLRKLGLSGSEAVDLL 122
|
|
| RfaJ |
COG1442 |
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ... |
1227-1355 |
9.65e-12 |
|
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441051 [Multi-domain] Cd Length: 301 Bit Score: 67.69 E-value: 9.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1227 KDVLNIFSVASGHlYERFLRIMMLSVLRNTK-TPVKFWFLKNYLSPAFKEIIPYMAKEYGFQYELVQYKwPHWLHQQTEK 1305
Cdd:COG1442 3 KNTINIVFAIDDN-YLPGLGVSIASLLENNPdRPYDFHILTDGLSDENKERLEALAAKYNVSIEFIDVD-DELLKDLPVS 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 829791201 1306 QRIIWG--YKiLFLDVLFPLSVDKIIFVDADQIVRHDLKELRDFDLDGAPYG 1355
Cdd:COG1442 81 KHISKAtyYR-LLIPELLPDDYDKVLYLDADTLVLGDLSELWDIDLGGNLLA 131
|
|
| PLN02870 |
PLN02870 |
Probable galacturonosyltransferase |
1315-1412 |
7.70e-04 |
|
Probable galacturonosyltransferase
Pssm-ID: 215468 [Multi-domain] Cd Length: 533 Bit Score: 43.77 E-value: 7.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1315 LFLDVLFPlSVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCD-------SRREMDGYRF---------------W 1372
Cdd:PLN02870 334 IYLPELFP-NLDKVVFLDDDVVIQRDLSPLWDIDLGGKVNGAVETCRgedewvmSKRFRNYFNFshpliaknldpeecaW 412
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 829791201 1373 KTGY-------WASHLIRRKYHiravSFMTDNLrKLEVTIKRIWILP 1412
Cdd:PLN02870 413 AYGMnifdlraWRKTNIRETYH----SWLKENL-KSNLTMWKLGTLP 454
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Glyco_transf_24 |
pfam18404 |
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein ... |
1231-1390 |
2.71e-114 |
|
Glucosyltransferase 24; This is the catalytic domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT). This domain belongs to glucosyltransferase 24 family (GT24) A-type domain. The GT domain displays the expected glycosyltransferase type A (GT-A) fold.
Pssm-ID: 436473 Cd Length: 268 Bit Score: 360.01 E-value: 2.71e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1231 NIFSVASGHLYERFLRIMMLSVLRNTKTPVKFWFLKNYLSPAFKEIIPYMAKEYGFQYELVQYKWPHWLHQQTEKQRIIW 1310
Cdd:pfam18404 2 NIFSVASGHLYERFLKIMMLSVRKNTKSPVKFWFIENFLSPSFKAFLPHLAKEYGFEYELVTYKWPSWLRKQTEKQRIIW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1311 GYKILFLDVLFPLSVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCDSRREMDGYRFWKTGYWASHLIRRKYHIRA 1390
Cdd:pfam18404 82 GYKILFLDVLFPLDLDKVIFVDADQVVRTDLKELVDMDLEGAPYGYTPMCDSRKEMEGFRFWKQGYWKDHLRGRPYHISA 161
|
|
| GT8_HUGT1_C_like |
cd06432 |
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain ... |
1230-1390 |
3.90e-111 |
|
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.
Pssm-ID: 133054 Cd Length: 248 Bit Score: 350.54 E-value: 3.90e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1230 LNIFSVASGHLYERFLRIMMLSVLRNTKTPVKFWFLKNYLSPAFKEIIPYMAKEYGFQYELVQYKWPHWLHQQTEKQRII 1309
Cdd:cd06432 1 INIFSVASGHLYERFLRIMMLSVMKNTKSPVKFWFIKNFLSPQFKEFLPEMAKEYGFEYELVTYKWPRWLHKQTEKQRII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1310 WGYKILFLDVLFPLSVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCDSRREMDGYRFWKTGYWASHLIRRKYHIR 1389
Cdd:cd06432 81 WGYKILFLDVLFPLNVDKVIFVDADQIVRTDLKELMDMDLKGAPYGYTPFCDSRKEMDGFRFWKQGYWKSHLRGRPYHIS 160
|
.
gi 829791201 1390 A 1390
Cdd:cd06432 161 A 161
|
|
| Thioredoxin_12 |
pfam18400 |
Thioredoxin-like domain; This is one of four TRXL(thioredoxin-like) domains found in ... |
45-226 |
1.09e-69 |
|
Thioredoxin-like domain; This is one of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465748 Cd Length: 187 Bit Score: 231.74 E-value: 1.09e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 45 ETPLLLEASEFMAEESNEKFWQFLGTVQELAIY-KQTESDYSYYNLILKKAGQFLDNLHINLLKFALSLRAYSPAIHMFQ 123
Cdd:pfam18400 1 ATPLLLEALETLAEENPDLFFPFLDALTNLDGEfADASTDEELYEAALKLASDHLSPLALSLFKLALSLRSASPRIEAFY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 124 QIAAD----EPPPDGCNAFVVIHKKHTCKINEIKKLLKK-ATSRPRPYLFKVDHKFPTNKEnLPVIILYAEMGTRAFSAF 198
Cdd:pfam18400 81 QIYAEsvsfEGAPPECDSWVDWGGEVYCDPEDLDALLKSeASSRPQPELLPFDHVYPDSGS-SPVAILYADLGSPNFREF 159
|
170 180
....*....|....*....|....*...
gi 829791201 199 HKVLSEKAQNGEILYVLRHYIQKPSSRK 226
Cdd:pfam18400 160 HKYLSELAKDGKIRYVLRHVPPSGSESK 187
|
|
| Thioredoxin_14 |
pfam18402 |
Thioredoxin-like domain; This is the third out of four TRXL(thioredoxin-like) domains found in ... |
437-685 |
2.10e-62 |
|
Thioredoxin-like domain; This is the third out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465750 Cd Length: 248 Bit Score: 213.29 E-value: 2.10e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 437 LDIRHS-----SIMWINDLENDGMYVTWPTSCQELLKPVFPGSIPTIRRNFHNLVLFIDPAQ-EYTLDFFKLAELFYFHK 510
Cdd:pfam18402 1 FDIRDRiegggVIIWLNDLEKDKRYSRWPSSLQELLRPTYPGQLPPIRKNLFNLVLVVDLSQpEDLLLLVETLQSFVQRG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 511 VPLRIGFVFILNTDDEvdgaddaGVALWRAFNYITEESDESEAFISVVH-MYQKLKAQSILTVDNVKNVLQNKFPHASIW 589
Cdd:pfam18402 81 IPVRFGLVPLVNSTED-------GLAQAKLFYYLLENYGLKAALSFLTAsLYALAKKVLSPTKAIFSSALKERTLRPQAL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 590 DILGI--HSKFDKERKAGASFYKMTGLGPL--PQALyNGEPFSHEEmnikELEMAVLQRMMAASIYLQKDVFMGTLNDRT 665
Cdd:pfam18402 154 SFDEVlkSEVYDERLKKAKEYLKRLGLDSLsgPVFV-NGVPLPRDE----NWLQALSQRISEDLQLLQKAVYEGALTDDD 228
|
250 260
....*....|....*....|
gi 829791201 666 NAIDFLMDRKNVVPRINSLI 685
Cdd:pfam18402 229 DVPDFFYDLPNALPRRNPLI 248
|
|
| Thioredoxin_15 |
pfam18403 |
Thioredoxin-like domain; This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose: ... |
709-932 |
5.99e-60 |
|
Thioredoxin-like domain; This is the fourth TRXL(thioredoxin-like) domain found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465751 Cd Length: 205 Bit Score: 204.77 E-value: 5.99e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 709 TFFFLDSQdkSAVIAKNMHYLTEKDDnVISAVTVWIIADFDKPSGRKLLFNALKHMRTSVHSRLGVIYNPTSKiNEENTA 788
Cdd:pfam18403 1 DLNKLYSE--HADLFDKMPYLEASSD-KEDWATLWVVADLDSESGRKLLLSALEFRKSNPGVRLGIIHNPASP-SEASSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 789 ISRGILAAFLTQKNSFLGSLLRKLAKEETATAIYSGdkiktfftegmdkntfeKKYNTIGVNIFRTHQLFCQdVLKLRPG 868
Cdd:pfam18403 77 ISSALLAALLKLKNLDALEFLTKLLEEEEAAASESG-----------------KSSAEAAADYWKALQPFLR-VLGLKPG 138
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 829791201 869 EMGIVSNGRFLGPLDKD--FYAEDFYLLEKITFSNSLEKIKGIVENMDINSK-NMSDLVMKVDALVS 932
Cdd:pfam18403 139 QNALVLNGRVVGPIPEDeeFSADDFELLLSYERSKRIEPVYKAIEELGLEDKiSDPDAVAKLTSLVA 205
|
|
| Glyco_transf_8 |
cd00505 |
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis ... |
1230-1424 |
1.37e-51 |
|
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis; Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.
Pssm-ID: 132996 [Multi-domain] Cd Length: 246 Bit Score: 182.26 E-value: 1.37e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1230 LNIFSVASGHLYERFLRIMMLSVLRNTKTPVKFWFLKNYLSPAFKEIIPYMAKEYGFQYELVQYKWPHWLHQQTE-KQRI 1308
Cdd:cd00505 1 IAIVIVATGDEYLRGAIVLMKSVLRHRTKPLRFHVLTNPLSDTFKAALDNLRKLYNFNYELIPVDILDSVDSEHLkRPIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1309 IWGYKILFLDVLFPlSVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCDSRREMDGYRfwktgYWASHLIRRKYHI 1388
Cdd:cd00505 81 IVTLTKLHLPNLVP-DYDKILYVDADILVLTDIDELWDTPLGGQELAAAPDPGDRREGKYYR-----QKRSHLAGPDYFN 154
|
170 180 190
....*....|....*....|....*....|....*.
gi 829791201 1389 RAVsfMTDNLRKLevTIKRIWilpnsKKLQTPWKQY 1424
Cdd:cd00505 155 SGV--FVVNLSKE--RRNQLL-----KVALEKWLQS 181
|
|
| UDP-g_GGTase |
pfam06427 |
UDP-glucose:Glycoprotein Glucosyltransferase; This domain consists of 7 stranded ... |
1093-1198 |
1.39e-50 |
|
UDP-glucose:Glycoprotein Glucosyltransferase; This domain consists of 7 stranded beta-sandwiches found in UDP-glucose-glycoprotein glucosyltransferase-like proteins. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER.
Pssm-ID: 461910 Cd Length: 109 Bit Score: 173.83 E-value: 1.39e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1093 GYCFDTMTGQTPRGLQFTLGTKNKPVVVDTIVMAKLGYFQLKANPGAWILKLRKGKSEDIYQI--VGHEGPDSQPDlEDV 1170
Cdd:pfam06427 2 GHARDVTTGSPPRGLQLVLGTEKNPHVADTIVMANLGYFQLKANPGVWKLELREGRSSDIYEIesVGAEGWPSPGD-EGT 80
|
90 100
....*....|....*....|....*...
gi 829791201 1171 IVVLNSFKSKTLQVQVQKKPDKIKEDIL 1198
Cdd:pfam06427 81 EVALTSFEGLTLYPRLSRKPGMENEDVL 108
|
|
| Thioredoxin_13 |
pfam18401 |
Thioredoxin-like domain; This is the second out of four TRXL(thioredoxin-like) domains found ... |
296-424 |
3.44e-45 |
|
Thioredoxin-like domain; This is the second out of four TRXL(thioredoxin-like) domains found in UDP-glucose:glycoprotein glucosyltransferase (UGGT).
Pssm-ID: 465749 Cd Length: 136 Bit Score: 159.66 E-value: 3.44e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 296 ESNKEMMPLKVWELQDLSFQAASQIMSTPvyDAIKLMKDISQNFPIKARSLTRIAVNQHMREEIQENQKDLqdgfeIQPG 375
Cdd:pfam18401 1 EEVEDLKPLSVWELQDLGLQAAQFIMSSD--DPLDTLLKLSQDFPKYASSLARHNVSDELREEIEENQERL-----LPPG 73
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 829791201 376 DARLFINGLRIDIDVYDPFSILDMLKLEGKMMNGLRNLGINEEDTSKFL 424
Cdd:pfam18401 74 DNALWLNGLQLDERDIDPFSLLDILRRERKLINGLRKLGLSGSEAVDLL 122
|
|
| RfaJ |
COG1442 |
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ... |
1227-1355 |
9.65e-12 |
|
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441051 [Multi-domain] Cd Length: 301 Bit Score: 67.69 E-value: 9.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1227 KDVLNIFSVASGHlYERFLRIMMLSVLRNTK-TPVKFWFLKNYLSPAFKEIIPYMAKEYGFQYELVQYKwPHWLHQQTEK 1305
Cdd:COG1442 3 KNTINIVFAIDDN-YLPGLGVSIASLLENNPdRPYDFHILTDGLSDENKERLEALAAKYNVSIEFIDVD-DELLKDLPVS 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 829791201 1306 QRIIWG--YKiLFLDVLFPLSVDKIIFVDADQIVRHDLKELRDFDLDGAPYG 1355
Cdd:COG1442 81 KHISKAtyYR-LLIPELLPDDYDKVLYLDADTLVLGDLSELWDIDLGGNLLA 131
|
|
| GT8_A4GalT_like |
cd04194 |
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the ... |
1241-1355 |
4.64e-08 |
|
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.
Pssm-ID: 133037 [Multi-domain] Cd Length: 248 Bit Score: 55.68 E-value: 4.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1241 YERFLRIMMLSVLRNT-KTPVKFWFLKNYLSPAFKEIIPYMAKEYGFQYELVQYKWPHWLHQQTEKQRiiWGYKI---LF 1316
Cdd:cd04194 11 YAPYLAVTIKSILANNsKRDYDFYILNDDISEENKKKLKELLKKYNSSIEFIKIDNDDFKFFPATTDH--ISYATyyrLL 88
|
90 100 110
....*....|....*....|....*....|....*....
gi 829791201 1317 LDVLFPlSVDKIIFVDADQIVRHDLKELRDFDLDGAPYG 1355
Cdd:cd04194 89 IPDLLP-DYDKVLYLDADIIVLGDLSELFDIDLGDNLLA 126
|
|
| PLN02870 |
PLN02870 |
Probable galacturonosyltransferase |
1315-1412 |
7.70e-04 |
|
Probable galacturonosyltransferase
Pssm-ID: 215468 [Multi-domain] Cd Length: 533 Bit Score: 43.77 E-value: 7.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829791201 1315 LFLDVLFPlSVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCD-------SRREMDGYRF---------------W 1372
Cdd:PLN02870 334 IYLPELFP-NLDKVVFLDDDVVIQRDLSPLWDIDLGGKVNGAVETCRgedewvmSKRFRNYFNFshpliaknldpeecaW 412
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 829791201 1373 KTGY-------WASHLIRRKYHiravSFMTDNLrKLEVTIKRIWILP 1412
Cdd:PLN02870 413 AYGMnifdlraWRKTNIRETYH----SWLKENL-KSNLTMWKLGTLP 454
|
|
| |
