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Conserved domains on  [gi|829787031|ref|XP_012624343|]
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U4/U6 small nuclear ribonucleoprotein Prp4 isoform X2 [Microcebus murinus]

Protein Classification

U4/U6 small nuclear ribonucleoprotein Prp4 family protein( domain architecture ID 10649556)

U4/U6 small nuclear ribonucleoprotein Prp4 family protein may play a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as a component of the precatalytic spliceosome

CATH:  2.130.10.10
Gene Ontology:  GO:0008380|GO:0005681|GO:0005515
PubMed:  30069656|29026209|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
228-518 2.94e-85

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 269.09  E-value: 2.94e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 228 GDDRPISFCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLW 307
Cdd:COG2319  118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL--------LASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 308 SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 387
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 388 GRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWDLRQRRCIYTIPAHQNLVTGVKFEPiHGNFLLTG 467
Cdd:COG2319  270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASG 348

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 829787031 468 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:COG2319  349 SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
SFM smart00500
Splicing Factor Motif, present in Prp18 and Pr04;
102-140 3.57e-15

Splicing Factor Motif, present in Prp18 and Pr04;


:

Pssm-ID: 128776  Cd Length: 44  Bit Score: 69.31  E-value: 3.57e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 829787031   102 TDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVG 140
Cdd:smart00500   1 LPDSEVIRRLRELGEPITLFGEDDQERRQRLRQLLIVQD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
228-518 2.94e-85

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 269.09  E-value: 2.94e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 228 GDDRPISFCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLW 307
Cdd:COG2319  118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL--------LASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 308 SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 387
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 388 GRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWDLRQRRCIYTIPAHQNLVTGVKFEPiHGNFLLTG 467
Cdd:COG2319  270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASG 348

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 829787031 468 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:COG2319  349 SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 232-518 4.82e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 251.87  E-value: 4.82e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 232 PISFCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDS 311
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY--------LASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 312 DEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVW 391
Cdd:cd00200   83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 392 DLRTGRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWDLRQRRCIYTIPAHQNLVTGVKFEPiHGNFLLTGAYDN 471
Cdd:cd00200  163 DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDG 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 829787031 472 TAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:cd00200  242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
SFM smart00500
Splicing Factor Motif, present in Prp18 and Pr04;
102-140 3.57e-15

Splicing Factor Motif, present in Prp18 and Pr04;


Pssm-ID: 128776  Cd Length: 44  Bit Score: 69.31  E-value: 3.57e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 829787031   102 TDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVG 140
Cdd:smart00500   1 LPDSEVIRRLRELGEPITLFGEDDQERRQRLRQLLIVQD 39
PRP4 pfam08799
pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. ...
 107-135 7.57e-12

pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing.


Pssm-ID: 462606 [Multi-domain]  Cd Length: 29  Bit Score: 59.62  E-value: 7.57e-12
                          10        20
                  ....*....|....*....|....*....
gi 829787031  107 VKACLRALGEPITLFGEGPAERRERLRNI 135
Cdd:pfam08799   1 VRRKLRELGEPITLFGETHADRRERLRKL 29
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 395-434 7.42e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 7.42e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 829787031   395 TGRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWD 434
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
396-434 5.12e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 5.12e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 829787031  396 GRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWD 434
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 227-366 2.55e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.97  E-value: 2.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 227 IGDDRPISFCHFSP-NSKMLATACWSGLCKLWSVPD--------CNLLHtLRGHNTNVGAIVFHPKStvsldqKDVnLAS 297
Cdd:PTZ00421  72 LGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEegltqnisDPIVH-LQGHTKKVGIVSFHPSA------MNV-LAS 143

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 829787031 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMG 366
Cdd:PTZ00421 144 AGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA 212
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
228-518 2.94e-85

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 269.09  E-value: 2.94e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 228 GDDRPISFCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLW 307
Cdd:COG2319  118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL--------LASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 308 SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 387
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 388 GRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWDLRQRRCIYTIPAHQNLVTGVKFEPiHGNFLLTG 467
Cdd:COG2319  270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASG 348

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 829787031 468 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:COG2319  349 SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 232-518 4.82e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 251.87  E-value: 4.82e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 232 PISFCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDS 311
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY--------LASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 312 DEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVW 391
Cdd:cd00200   83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 392 DLRTGRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWDLRQRRCIYTIPAHQNLVTGVKFEPiHGNFLLTGAYDN 471
Cdd:cd00200  163 DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDG 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 829787031 472 TAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:cd00200  242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
228-518 5.39e-77

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 247.90  E-value: 5.39e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 228 GDDRPISFCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLW 307
Cdd:COG2319   76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKT--------LASGSADGTVRLW 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 308 SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 387
Cdd:COG2319  148 DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 388 GRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWDLRQRRCIYTIPAHQNLVTGVKFEPiHGNFLLTG 467
Cdd:COG2319  228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASG 306

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 829787031 468 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:COG2319  307 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
238-518 6.84e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 224.02  E-value: 6.84e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 238 FSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVAD 317
Cdd:COG2319   44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL--------LASASADGTVRLWDLATGLLLRT 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 318 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGR 397
Cdd:COG2319  116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 398 CIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWDLRQRRCIYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIWT 477
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWD 274

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 829787031 478 HPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:COG2319  275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 314-518 1.69e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 190.24  E-value: 1.69e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 314 PVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDL 393
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 394 RTGRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWDLRQRRCIYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTA 473
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTI 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 829787031 474 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
228-436 1.68e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.89  E-value: 1.68e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 228 GDDRPISFCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLW 307
Cdd:COG2319  202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL--------LASGSADGTVRLW 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 308 SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 387
Cdd:COG2319  274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 829787031 388 GRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWDLR 436
Cdd:COG2319  354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
287-518 2.88e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 2.88e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 287 SLDQKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMG 366
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 367 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWDLRQRRCIYTIPA 446
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 829787031 447 HQNLVTGVKFEPiHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:COG2319  161 HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 236-434 4.02e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.50  E-value: 4.02e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 236 CHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPV 315
Cdd:cd00200   99 VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF--------VASSSQDGTIKLWDLRTGKCV 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 316 ADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRT 395
Cdd:cd00200  171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 829787031 396 GRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWD 434
Cdd:cd00200  251 GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
228-395 7.35e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.82  E-value: 7.35e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 228 GDDRPISFCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLW 307
Cdd:COG2319  244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL--------LASGSDDGTVRLW 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 308 SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 387
Cdd:COG2319  316 DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                 ....*...
gi 829787031 388 GRVWDLRT 395
Cdd:COG2319  396 VRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 231-392 4.31e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 4.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 231 RPISFCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTvsldqkdvNLASCAADGSVKLWSLD 310
Cdd:cd00200  136 DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGE--------KLLSSSSDGTIKLWDLS 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 311 SDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRV 390
Cdd:cd00200  208 TGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287


                 ..
gi 829787031 391 WD 392
Cdd:cd00200  288 WD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-350 5.70e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 5.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 230 DRPISFCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSL 309
Cdd:cd00200  177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL--------LASGSEDGTIRVWDL 248

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 829787031 310 DSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 350
Cdd:cd00200  249 RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
SFM smart00500
Splicing Factor Motif, present in Prp18 and Pr04;
102-140 3.57e-15

Splicing Factor Motif, present in Prp18 and Pr04;


Pssm-ID: 128776  Cd Length: 44  Bit Score: 69.31  E-value: 3.57e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 829787031   102 TDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVG 140
Cdd:smart00500   1 LPDSEVIRRLRELGEPITLFGEDDQERRQRLRQLLIVQD 39
PRP4 pfam08799
pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. ...
 107-135 7.57e-12

pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing.


Pssm-ID: 462606 [Multi-domain]  Cd Length: 29  Bit Score: 59.62  E-value: 7.57e-12
                          10        20
                  ....*....|....*....|....*....
gi 829787031  107 VKACLRALGEPITLFGEGPAERRERLRNI 135
Cdd:pfam08799   1 VRRKLRELGEPITLFGETHADRRERLRKL 29
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 216-308 5.26e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 5.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 216 SLRSLNNFCSQIGDDRPISFCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnL 295
Cdd:cd00200  205 DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR--------L 276

                         90
                 ....*....|...
gi 829787031 296 ASCAADGSVKLWS 308
Cdd:cd00200  277 ASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 395-434 7.42e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 7.42e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 829787031   395 TGRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWD 434
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
396-434 5.12e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 5.12e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 829787031  396 GRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWD 434
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
481-518 2.45e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 2.45e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 829787031  481 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 481-518 2.46e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 2.46e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 829787031   481 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 227-366 2.55e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.97  E-value: 2.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 227 IGDDRPISFCHFSP-NSKMLATACWSGLCKLWSVPD--------CNLLHtLRGHNTNVGAIVFHPKStvsldqKDVnLAS 297
Cdd:PTZ00421  72 LGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEegltqnisDPIVH-LQGHTKKVGIVSFHPSA------MNV-LAS 143

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 829787031 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMG 366
Cdd:PTZ00421 144 AGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA 212
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 377-518 6.71e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 6.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 377 SLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP-NGYHVATGSGDNTCKVWDLRQRRCIYTIPAHQNlVTGVK 455
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQ 624

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 829787031 456 FEPIHGNFLLTGAYDNTAKIWT--HPGWsPLKTLAGHEGKVMGLDISSDGQLIATcSYDRTFKLW 518
Cdd:PLN00181 625 FPSESGRSLAFGSADHKVYYYDlrNPKL-PLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 437-476 4.72e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.72e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 829787031   437 QRRCIYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIW 476
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 311-350 4.90e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.90e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 829787031   311 SDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 350
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
438-476 7.89e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.89e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 829787031  438 RRCIYTIPAHQNLVTGVKFEPiHGNFLLTGAYDNTAKIW 476
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
313-350 3.80e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 3.80e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 829787031  313 EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 350
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 263-308 6.24e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 6.24e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 829787031   263 NLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWS 308
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKY--------LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
263-308 1.20e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 829787031  263 NLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWS 308
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL--------LASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 319-448 3.24e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.34  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 319 EGHTVRVARVMWHPSGRFlgTTCYDRSWRLWDLEAQ-------EEILHQEGHSMGVYDIAFH--QDGSLAgTGGLDAFGR 389
Cdd:PTZ00421  75 EGPIIDVAFNPFDPQKLF--TASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSFHpsAMNVLA-SAGADMVVN 151

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 829787031 390 VWDLRTGRCIMFLEGHLKEIYGINFSPNGYHVATGSGDNTCKVWDLRQRRCIYTIPAHQ 448
Cdd:PTZ00421 152 VWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
PTZ00420 PTZ00420
coronin; Provisional
 268-355 4.32e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.01  E-value: 4.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829787031 268 LRGHNTNVGAIVFHP-KSTVsldqkdvnLASCAADGSVKLWSL-DSDEPVADIE-------GHTVRVARVMWHPSGRF-L 337
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEI--------LASGSEDLTIRVWEIpHNDESVKEIKdpqcilkGHKKKISIIDWNPMNYYiM 141

                         90
                 ....*....|....*...
gi 829787031 338 GTTCYDRSWRLWDLEAQE 355
Cdd:PTZ00420 142 CSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
361-392 7.05e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 7.05e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 829787031  361 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWD 392
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 361-392 2.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.18e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 829787031   361 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWD 392
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-258 2.73e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.73e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 829787031   228 GDDRPISFCHFSPNSKMLATACWSGLCKLWS 258
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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