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Conserved domains on  [gi|803117896|ref|XP_012040775|]
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LYR motif-containing protein 9 isoform X3 [Ovis aries]

Protein Classification

LYR motif-containing protein 9( domain architecture ID 14448886)

LYR motif-containing protein 9 (LYRM9)

PubMed:  24059529

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Complex1_LYR_LYRM9 cd20269
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and ...
 13-73 1.13e-31

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and similar proteins; LYRM9 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


:

Pssm-ID: 380764  Cd Length: 60  Bit Score: 104.63  E-value: 1.13e-31
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 803117896 13 PLQLYRYLLRCCRQLPtKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADWILNK 73
Cdd:cd20269   1 PLQLYRYLLRCCRRLP-KDTRDYYRHYARQNFVSHRDEDDPERIQQIIERAYEDAKWVLKK 60
 
Name Accession Description Interval E-value
Complex1_LYR_LYRM9 cd20269
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and ...
 13-73 1.13e-31

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and similar proteins; LYRM9 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380764  Cd Length: 60  Bit Score: 104.63  E-value: 1.13e-31
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 803117896 13 PLQLYRYLLRCCRQLPtKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADWILNK 73
Cdd:cd20269   1 PLQLYRYLLRCCRRLP-KDTRDYYRHYARQNFVSHRDEDDPERIQQIIERAYEDAKWVLKK 60
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 11-69 2.84e-14

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 60.28  E-value: 2.84e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 803117896  11 QTPLQLYRYLLRCCRQLPTKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADW 69
Cdd:pfam05347  1 RQVLSLYRALLRAARKFPDYNFREYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELEE 59
 
Name Accession Description Interval E-value
Complex1_LYR_LYRM9 cd20269
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and ...
 13-73 1.13e-31

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and similar proteins; LYRM9 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380764  Cd Length: 60  Bit Score: 104.63  E-value: 1.13e-31
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 803117896 13 PLQLYRYLLRCCRQLPtKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADWILNK 73
Cdd:cd20269   1 PLQLYRYLLRCCRRLP-KDTRDYYRHYARQNFVSHRDEDDPERIQQIIERAYEDAKWVLKK 60
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 11-69 2.84e-14

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 60.28  E-value: 2.84e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 803117896  11 QTPLQLYRYLLRCCRQLPTKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADW 69
Cdd:pfam05347  1 RQVLSLYRALLRAARKFPDYNFREYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELEE 59
Complex1_LYR_SF cd20251
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ...
 13-69 3.72e-14

LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.


Pssm-ID: 380755  Cd Length: 57  Bit Score: 60.25  E-value: 3.72e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 803117896 13 PLQLYRYLLRCCRQLPTKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADW 69
Cdd:cd20251   1 VLKLYRDLLRLARKGLPSRKRDALRQRIREEFRKNKNETDPEKIEELLAEARRGLKN 57
Complex1_LYR_unchar cd20273
LYR (leucine-tyrosine-arginine) motif found in uncharacterized LYR motif-containing protein; ...
 13-63 8.24e-09

LYR (leucine-tyrosine-arginine) motif found in uncharacterized LYR motif-containing protein; This group contains uncharacterized LYR motif-containing proteins belonging to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380768  Cd Length: 61  Bit Score: 46.80  E-value: 8.24e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 803117896 13 PLQLYRYLLRCCRQLPTKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRA 63
Cdd:cd20273   1 ALALYRALLREASYLPDPVARNYLRNHIRSRFRKNRNETSPKRLRKRLKKA 51
Complex1_LYR_LYRM2 cd20262
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and ...
 14-57 3.24e-05

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and similar proteins; LYRM2 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes; these proteins contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380757  Cd Length: 63  Bit Score: 37.52  E-value: 3.24e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 803117896 14 LQLYRYLLRCCRQLPTKGIQEHYKHAVRQSFRVHSDEDNPERIQ 57
Cdd:cd20262   7 LSLYRDILRAIRKIPDPSTRRELRDWVREEFERNRNETDEDAIK 50
Complex1_LYR_LYRM4 cd20264
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and ...
 14-68 9.41e-05

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins; LYRM4, also called ISD11, is a eukaryote-specific component of the mitochondrial biogenesis of Fe-S clusters which are essential cofactors in multiple processes, including oxidative phosphorylation. It is required for nuclear and mitochondrial iron-sulfur protein biosynthesis by forming a complex with, and stabilizing, the sulfur donor NFS1. LYRM4 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380759  Cd Length: 69  Bit Score: 36.34  E-value: 9.41e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 803117896 14 LQLYRYLLRCCRQLPTKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDAD 68
Cdd:cd20264   3 LSLYRALLREARKFPDYNFREYFLRRIRDAFRENKNLKDPEEIKKLYEEGEEQLE 57
Complex1_LYR_2 pfam13233
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ...
 13-63 1.07e-03

Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.


Pssm-ID: 463812  Cd Length: 79  Bit Score: 33.86  E-value: 1.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 803117896  13 PLQLYRYLLRCCRQLPtKGIQEHYKHAVRQSFRVHSDEDNPERIQQIIKRA 63
Cdd:pfam13233  1 VLSLYRALLRELRELP-PNGRSYGRQYLRAEFRRHKHLTDPEEIAEFLKSW 50
Complex1_LYR_LYRM1 cd20261
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and ...
 14-63 1.77e-03

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins; LYR motif-containing protein 1 (LYRM1) may promote cell proliferation and inhibition of apoptosis of preadipocytes. Overexpression of the human LYRM1 causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes. LYRM1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380756  Cd Length: 70  Bit Score: 33.37  E-value: 1.77e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 803117896 14 LQLYRYLLRCCRQLPTKGIQEHY--KHAVRQSFRVHSDEDNPERIQQIIKRA 63
Cdd:cd20261   3 LSLYRRILRLARTWPADTEEEREyiLNEARSLFRKNKNLTDPEEIEEKIQEA 54
Complex1_LYR_MIEF1-MP cd20272
LYR (leucine-tyrosine-arginine) motif found in mitochondrial elongation factor 1 microprotein ...
 14-65 1.99e-03

LYR (leucine-tyrosine-arginine) motif found in mitochondrial elongation factor 1 microprotein (MIEF1-MP) and similar proteins; MIEF1-MP, also called alternative mitochondrial elongation factor 1 (MIEF1) protein (AltMIEF1), or MIEF1 upstream open reading frame protein, is involved in the regulation of mitochondrial fission mediated by dynamin-1-like protein (DNM1L). It positively regulates mitochondrial translation. MIEF1-MP belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380767  Cd Length: 58  Bit Score: 33.01  E-value: 1.99e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 803117896 14 LQLYRYLLRCCRQLPTKGiQEHYKHAVRQSFRVHSDEDNPERIQQIIKRAIE 65
Cdd:cd20272   4 LSLYRALLRYGRQLRYTD-KDYYRRRIRREFEKNQNLTDPEAIEFQYEKGQK 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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