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Conserved domains on  [gi|795477813|ref|XP_011892272|]
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PREDICTED: mannan-binding lectin serine protease 1 isoform X4 [Cercocebus atys]

Protein Classification

CUB domain-containing protein( domain architecture ID 12870333)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein similar to CUB domain-containing protein 2 (CDCP2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 449-694 9.37e-84

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


:

Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 264.14  E-value: 9.37e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 449 IFNGRPAQQGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSldpedptlrnsdllSPSDFKIILGKHWRLRSDE 528
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSLQYTGGRHFCGGSLISPRWVLTAAHCVYSS--------------APSNYTVRLGSHDLSSNEG 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 529 NEQHLRVKHITLHPQYDPSTFENDVALVElLDSPV-LNAFVMPICLPEGPQ--QEGAMVIVSGWGK-QFLQRFPETLMEI 604
Cdd:cd00190   67 GGQVIKVKKVIVHPNYNPSTYDNDIALLK-LKRPVtLSDNVRPICLPSSGYnlPAGTTCTVSGWGRtSEGGPLPDVLQEV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 605 EIPIADHGTCQKAYaPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTlnRERGQWYLVGTVSWGDDCGKKDRYGVYSYI 684
Cdd:cd00190  146 NVPIVSNAECKRAY-SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVC--NDNGRGVLVGIVSWGSGCARPNYPGVYTRV 222

                        250
                 ....*....|
gi 795477813 685 HHNKDWIQRV 694
Cdd:cd00190  223 SSYLDWIQKT 232
CUB pfam00431
CUB domain;
185-294 5.57e-39

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 139.35  E-value: 5.57e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813  185 CSDNlFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDiFDIEDHPEvpCPYDYIKIKVGPK----VLGPFC 260
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGPSasspLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 795477813  261 GEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 28-137 2.07e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 115.59  E-value: 2.07e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813  28 FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGRETTdteqtpg 103
Cdd:cd00041   10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 795477813 104 qEVVLSPGSFMSITFRSDFSNeeRFTGFDAHYMA 137
Cdd:cd00041   83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 301-363 1.23e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 60.17  E-value: 1.23e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795477813 301 CPELQPPVHGKIEPSQAKYSFKDQVLISCDTGYKVLKDNvemdtfQIECLKDGTWSNKIPTCK 363
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSS------TITCTENGGWSPPPPTCE 57
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 153-181 1.50e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 1.50e-08
                          10        20
                  ....*....|....*....|....*....
gi 795477813  153 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 181
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA02639 super family cl31493
EEV host range protein; Provisional
 300-433 9.83e-07

EEV host range protein; Provisional


The actual alignment was detected with superfamily member PHA02639:

Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 51.20  E-value: 9.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 300 ECPELQPPVHGKIEPSQAKYSFKDQVLISCDTGYKVLKDNVEMDtfQIECLKDGTWSNKIPTCKIVDCRAPGeLEHGLVT 379
Cdd:PHA02639  84 ECNDPPSIINGKIYNKREMYKVGDEIYYVCNEHKGVQYSLVGNE--KITCIQDKSWKPDPPICKMINCRFPA-LQNGYIN 160

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 795477813 380 FSTRNNLTTYKSEIRYSCQEPYYKMLNNITgiyTCSAQGVWMNkvlgrSLPTCL 433
Cdd:PHA02639 161 GIPSNKKFYYKTRVGFSCKSGFDLVGEKYS---TCNINATWFP-----SIPTCV 206
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 449-694 9.37e-84

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 264.14  E-value: 9.37e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 449 IFNGRPAQQGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSldpedptlrnsdllSPSDFKIILGKHWRLRSDE 528
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSLQYTGGRHFCGGSLISPRWVLTAAHCVYSS--------------APSNYTVRLGSHDLSSNEG 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 529 NEQHLRVKHITLHPQYDPSTFENDVALVElLDSPV-LNAFVMPICLPEGPQ--QEGAMVIVSGWGK-QFLQRFPETLMEI 604
Cdd:cd00190   67 GGQVIKVKKVIVHPNYNPSTYDNDIALLK-LKRPVtLSDNVRPICLPSSGYnlPAGTTCTVSGWGRtSEGGPLPDVLQEV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 605 EIPIADHGTCQKAYaPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTlnRERGQWYLVGTVSWGDDCGKKDRYGVYSYI 684
Cdd:cd00190  146 NVPIVSNAECKRAY-SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVC--NDNGRGVLVGIVSWGSGCARPNYPGVYTRV 222

                        250
                 ....*....|
gi 795477813 685 HHNKDWIQRV 694
Cdd:cd00190  223 SSYLDWIQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 448-691 3.64e-81

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 257.22  E-value: 3.64e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813   448 RIFNGRPAQQGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSldpedptlrnsdllSPSDFKIILGKHWRlRSD 527
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGRHFCGGSLISPRWVLTAAHCVRGS--------------DPSNIRVRLGSHDL-SSG 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813   528 ENEQHLRVKHITLHPQYDPSTFENDVALVELLDSPVLNAFVMPICLPEGPQQ--EGAMVIVSGWGKQFL--QRFPETLME 603
Cdd:smart00020  66 EEGQVIKVSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNvpAGTTCTVSGWGRTSEgaGSLPDTLQE 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813   604 IEIPIADHGTCQKAYaPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNrerGQWYLVGTVSWGDDCGKKDRYGVYSY 683
Cdd:smart00020 146 VNVPIVSNATCRRAY-SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCND---GRWVLVGIVSWGSGCARPGKPGVYTR 221


                   ....*...
gi 795477813   684 IHHNKDWI 691
Cdd:smart00020 222 VSSYLDWI 229
Trypsin pfam00089
Trypsin;
449-691 3.61e-70

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 228.10  E-value: 3.61e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813  449 IFNGRPAQQGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHqsldpedptlrnsdllSPSDFKIILGKHWRLRSDE 528
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSGKHFCGGSLISENWVLTAAHCVS----------------GASDVKVVLGAHNIVLREG 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813  529 NEQHLRVKHITLHPQYDPSTFENDVALVELLDSPVLNAFVMPICLPEGPQ--QEGAMVIVSGWGKQFLQRFPETLMEIEI 606
Cdd:pfam00089  65 GEQKFDVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSdlPVGTTCTVSGWGNTKTLGPSDTLQEVTV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813  607 PIADHGTCQKAYaplKKKVTRDMICAGekEGGKDACAGDSGGPMVTLNRergqwYLVGTVSWGDDCGKKDRYGVYSYIHH 686
Cdd:pfam00089 145 PVVSRETCRSAY---GGTVTDTMICAG--AGGKDACQGDSGGPLVCSDG-----ELIGIVSWGYGCASGNYPGVYTPVSS 214


                  ....*
gi 795477813  687 NKDWI 691
Cdd:pfam00089 215 YLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 447-696 3.84e-64

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 213.74  E-value: 3.84e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 447 ARIFNGRPAQQGTTPWIAMLSHLNG--QPFCGGSLLGSSWIVTAAHCLhqsldpedptlrnsDLLSPSDFKIILGKHwRL 524
Cdd:COG5640   29 PAIVGGTPATVGEYPWMVALQSSNGpsGQFCGGTLIAPRWVLTAAHCV--------------DGDGPSDLRVVIGST-DL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 525 RSDENEQHlRVKHITLHPQYDPSTFENDVALVELlDSPVlnAFVMPICLPEGPQQ--EGAMVIVSGWGK--QFLQRFPET 600
Cdd:COG5640   94 STSGGTVV-KVARIVVHPDYDPATPGNDIALLKL-ATPV--PGVAPAPLATSADAaaPGTPATVAGWGRtsEGPGSQSGT 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 601 LMEIEIPIADHGTCQkAYAPLkkkVTRDMICAGEKEGGKDACAGDSGGPMVtlNRERGQWYLVGTVSWGDDCGKKDRYGV 680
Cdd:COG5640  170 LRKADVPVVSDATCA-AYGGF---DGGTMLCAGYPEGGKDACQGDSGGPLV--VKDGGGWVLVGVVSWGGGPCAAGYPGV 243

                        250
                 ....*....|....*.
gi 795477813 681 YSYIHHNKDWIQRVTR 696
Cdd:COG5640  244 YTRVSAYRDWIKSTAG 259
CUB pfam00431
CUB domain;
185-294 5.57e-39

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 139.35  E-value: 5.57e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813  185 CSDNlFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDiFDIEDHPEvpCPYDYIKIKVGPK----VLGPFC 260
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGPSasspLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 795477813  261 GEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 185-296 1.05e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 130.61  E-value: 1.05e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 185 CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDiFDIEDHPEvpCPYDYIKIKVGP----KVLGPFC 260
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYDGPstssPLLGRFC 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 795477813 261 GEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRA 296
Cdd:cd00041   78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 195-294 2.21e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 117.88  E-value: 2.21e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813   195 GVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDiFDIEDHPEvpCPYDYIKIKVGP----KVLGPFCGEKAPEP-IS 269
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGPsassPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 795477813   270 TQSHSVLILFHSDNSGENRGWRLSY 294
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 28-137 2.07e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 115.59  E-value: 2.07e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813  28 FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGRETTdteqtpg 103
Cdd:cd00041   10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 795477813 104 qEVVLSPGSFMSITFRSDFSNeeRFTGFDAHYMA 137
Cdd:cd00041   83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 29-135 6.29e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 113.64  E-value: 6.29e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813    29 GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdteqtPGQ 104
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 795477813   105 EVVLSPGSFMSITFRSDFSNEERftGFDAHY 135
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKR--GFSARY 102
CUB pfam00431
CUB domain;
23-135 1.32e-22

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 93.13  E-value: 1.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813   23 ELNDMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdt 98
Cdd:pfam00431   4 VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGSG---- 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 795477813   99 eqtpGQEVVLSPGSFMSITFRSDFSNEERftGFDAHY 135
Cdd:pfam00431  80 ----IPEDIVSSSNQMTIKFVSDASVQKR--GFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 301-363 1.23e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 60.17  E-value: 1.23e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795477813 301 CPELQPPVHGKIEPSQAKYSFKDQVLISCDTGYKVLKDNvemdtfQIECLKDGTWSNKIPTCK 363
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSS------TITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
301-362 1.31e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 59.82  E-value: 1.31e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 795477813  301 CPELQPPVHGKIEPSQAKYSFKDQVLISCDTGYKVLKDNVemdtfqIECLKDGTWSNKIPTC 362
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 301-362 8.40e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.54  E-value: 8.40e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 795477813   301 CPELQPPVHGKIEPSQAKYSFKDQVLISCDTGYKVLKDNVemdtfqIECLKDGTWSNKIPTC 362
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSST------ITCLENGTWSPPPPTC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 153-181 1.50e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 1.50e-08
                          10        20
                  ....*....|....*....|....*....
gi 795477813  153 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 181
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA02639 PHA02639
EEV host range protein; Provisional
 300-433 9.83e-07

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 51.20  E-value: 9.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 300 ECPELQPPVHGKIEPSQAKYSFKDQVLISCDTGYKVLKDNVEMDtfQIECLKDGTWSNKIPTCKIVDCRAPGeLEHGLVT 379
Cdd:PHA02639  84 ECNDPPSIINGKIYNKREMYKVGDEIYYVCNEHKGVQYSLVGNE--KITCIQDKSWKPDPPICKMINCRFPA-LQNGYIN 160

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 795477813 380 FSTRNNLTTYKSEIRYSCQEPYYKMLNNITgiyTCSAQGVWMNkvlgrSLPTCL 433
Cdd:PHA02639 161 GIPSNKKFYYKTRVGFSCKSGFDLVGEKYS---TCNINATWFP-----SIPTCV 206
PHA02817 PHA02817
EEV Host range protein; Provisional
 306-401 1.23e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 46.86  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 306 PP--VHGKIEPSQAKYSFKDQVLISCDTG-----YKVLKDNVemdtfqIECLKDGTWSNKIPTCKIVDCRAPGeLEHGLV 378
Cdd:PHA02817  27 PPsiKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKN------IICEKDGKWNKEFPVCKIIRCRFPA-LQNGFV 99

                         90       100
                 ....*....|....*....|...
gi 795477813 379 TFSTRNNLTTYKSEIRYSCQEPY 401
Cdd:PHA02817 100 NGIPDSKKFYYESEVSFSCKPGF 122
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 367-432 3.59e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 41.68  E-value: 3.59e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795477813 367 CRAPGELEHGLVTFSTRNnlTTYKSEIRYSCqEPYYKMLNNitGIYTCSAQGVWMNkvlgrSLPTC 432
Cdd:cd00033    1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSC-NEGYTLVGS--STITCTENGGWSP-----PPPTC 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
139-181 4.80e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 4.80e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 795477813   139 DVDECKEREDeelsCDH--YCHNYIGGYYCSCRFGYilhTDNRTC 181
Cdd:smart00179   1 DIDECASGNP----CQNggTCVNTVGSYRCECPPGY---TDGRNC 38
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 367-432 6.67e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.97  E-value: 6.67e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795477813   367 CRAPGELEHGLVTFSTRNnlTTYKSEIRYSCQEPYYKMLNNITgiyTCSAQGVWMNkvlgrSLPTC 432
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPGYTLIGSSTI---TCLENGTWSP-----PPPTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 139-176 1.95e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 1.95e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 795477813 139 DVDECKEREdeelSCDHY--CHNYIGGYYCSCRFGYILHT 176
Cdd:cd00054    1 DIDECASGN----PCQNGgtCVNTVGSYRCSCPPGYTGRN 36
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 449-694 9.37e-84

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 264.14  E-value: 9.37e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 449 IFNGRPAQQGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSldpedptlrnsdllSPSDFKIILGKHWRLRSDE 528
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSLQYTGGRHFCGGSLISPRWVLTAAHCVYSS--------------APSNYTVRLGSHDLSSNEG 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 529 NEQHLRVKHITLHPQYDPSTFENDVALVElLDSPV-LNAFVMPICLPEGPQ--QEGAMVIVSGWGK-QFLQRFPETLMEI 604
Cdd:cd00190   67 GGQVIKVKKVIVHPNYNPSTYDNDIALLK-LKRPVtLSDNVRPICLPSSGYnlPAGTTCTVSGWGRtSEGGPLPDVLQEV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 605 EIPIADHGTCQKAYaPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTlnRERGQWYLVGTVSWGDDCGKKDRYGVYSYI 684
Cdd:cd00190  146 NVPIVSNAECKRAY-SYGGTITDNMLCAGGLEGGKDACQGDSGGPLVC--NDNGRGVLVGIVSWGSGCARPNYPGVYTRV 222

                        250
                 ....*....|
gi 795477813 685 HHNKDWIQRV 694
Cdd:cd00190  223 SSYLDWIQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 448-691 3.64e-81

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 257.22  E-value: 3.64e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813   448 RIFNGRPAQQGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSldpedptlrnsdllSPSDFKIILGKHWRlRSD 527
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGRHFCGGSLISPRWVLTAAHCVRGS--------------DPSNIRVRLGSHDL-SSG 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813   528 ENEQHLRVKHITLHPQYDPSTFENDVALVELLDSPVLNAFVMPICLPEGPQQ--EGAMVIVSGWGKQFL--QRFPETLME 603
Cdd:smart00020  66 EEGQVIKVSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNvpAGTTCTVSGWGRTSEgaGSLPDTLQE 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813   604 IEIPIADHGTCQKAYaPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNrerGQWYLVGTVSWGDDCGKKDRYGVYSY 683
Cdd:smart00020 146 VNVPIVSNATCRRAY-SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCND---GRWVLVGIVSWGSGCARPGKPGVYTR 221


                   ....*...
gi 795477813   684 IHHNKDWI 691
Cdd:smart00020 222 VSSYLDWI 229
Trypsin pfam00089
Trypsin;
449-691 3.61e-70

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 228.10  E-value: 3.61e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813  449 IFNGRPAQQGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHqsldpedptlrnsdllSPSDFKIILGKHWRLRSDE 528
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSGKHFCGGSLISENWVLTAAHCVS----------------GASDVKVVLGAHNIVLREG 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813  529 NEQHLRVKHITLHPQYDPSTFENDVALVELLDSPVLNAFVMPICLPEGPQ--QEGAMVIVSGWGKQFLQRFPETLMEIEI 606
Cdd:pfam00089  65 GEQKFDVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSdlPVGTTCTVSGWGNTKTLGPSDTLQEVTV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813  607 PIADHGTCQKAYaplKKKVTRDMICAGekEGGKDACAGDSGGPMVTLNRergqwYLVGTVSWGDDCGKKDRYGVYSYIHH 686
Cdd:pfam00089 145 PVVSRETCRSAY---GGTVTDTMICAG--AGGKDACQGDSGGPLVCSDG-----ELIGIVSWGYGCASGNYPGVYTPVSS 214


                  ....*
gi 795477813  687 NKDWI 691
Cdd:pfam00089 215 YLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 447-696 3.84e-64

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 213.74  E-value: 3.84e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 447 ARIFNGRPAQQGTTPWIAMLSHLNG--QPFCGGSLLGSSWIVTAAHCLhqsldpedptlrnsDLLSPSDFKIILGKHwRL 524
Cdd:COG5640   29 PAIVGGTPATVGEYPWMVALQSSNGpsGQFCGGTLIAPRWVLTAAHCV--------------DGDGPSDLRVVIGST-DL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 525 RSDENEQHlRVKHITLHPQYDPSTFENDVALVELlDSPVlnAFVMPICLPEGPQQ--EGAMVIVSGWGK--QFLQRFPET 600
Cdd:COG5640   94 STSGGTVV-KVARIVVHPDYDPATPGNDIALLKL-ATPV--PGVAPAPLATSADAaaPGTPATVAGWGRtsEGPGSQSGT 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 601 LMEIEIPIADHGTCQkAYAPLkkkVTRDMICAGEKEGGKDACAGDSGGPMVtlNRERGQWYLVGTVSWGDDCGKKDRYGV 680
Cdd:COG5640  170 LRKADVPVVSDATCA-AYGGF---DGGTMLCAGYPEGGKDACQGDSGGPLV--VKDGGGWVLVGVVSWGGGPCAAGYPGV 243

                        250
                 ....*....|....*.
gi 795477813 681 YSYIHHNKDWIQRVTR 696
Cdd:COG5640  244 YTRVSAYRDWIKSTAG 259
CUB pfam00431
CUB domain;
185-294 5.57e-39

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 139.35  E-value: 5.57e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813  185 CSDNlFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDiFDIEDHPEvpCPYDYIKIKVGPK----VLGPFC 260
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGPSasspLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 795477813  261 GEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 185-296 1.05e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 130.61  E-value: 1.05e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 185 CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDiFDIEDHPEvpCPYDYIKIKVGP----KVLGPFC 260
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYDGPstssPLLGRFC 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 795477813 261 GEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRA 296
Cdd:cd00041   78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 195-294 2.21e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 117.88  E-value: 2.21e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813   195 GVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDiFDIEDHPEvpCPYDYIKIKVGP----KVLGPFCGEKAPEP-IS 269
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGPsassPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 795477813   270 TQSHSVLILFHSDNSGENRGWRLSY 294
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 28-137 2.07e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 115.59  E-value: 2.07e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813  28 FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGRETTdteqtpg 103
Cdd:cd00041   10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 795477813 104 qEVVLSPGSFMSITFRSDFSNeeRFTGFDAHYMA 137
Cdd:cd00041   83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 29-135 6.29e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 113.64  E-value: 6.29e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813    29 GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdteqtPGQ 104
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 795477813   105 EVVLSPGSFMSITFRSDFSNEERftGFDAHY 135
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKR--GFSARY 102
CUB pfam00431
CUB domain;
23-135 1.32e-22

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 93.13  E-value: 1.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813   23 ELNDMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdt 98
Cdd:pfam00431   4 VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGSG---- 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 795477813   99 eqtpGQEVVLSPGSFMSITFRSDFSNEERftGFDAHY 135
Cdd:pfam00431  80 ----IPEDIVSSSNQMTIKFVSDASVQKR--GFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 301-363 1.23e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 60.17  E-value: 1.23e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795477813 301 CPELQPPVHGKIEPSQAKYSFKDQVLISCDTGYKVLKDNvemdtfQIECLKDGTWSNKIPTCK 363
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSS------TITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
301-362 1.31e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 59.82  E-value: 1.31e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 795477813  301 CPELQPPVHGKIEPSQAKYSFKDQVLISCDTGYKVLKDNVemdtfqIECLKDGTWSNKIPTC 362
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 463-699 1.48e-11

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 63.93  E-value: 1.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 463 IAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHqslDPEDPTLrnsdllsPSDFKIILGkhwrlRSDENEQHLRVKHITLHP 542
Cdd:COG3591    2 VGRLETDGGGGVCTGTLIGPNLVLTAGHCVY---DGAGGGW-------ATNIVFVPG-----YNGGPYGTATATRFRVPP 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 543 QYDPST-FENDVALVElLDSPVLNAF-VMPIcLPEGPQQEGAMVIVSGWGkqflqrfpetlmeieipiADHGtcqkayap 620
Cdd:COG3591   67 GWVASGdAGYDYALLR-LDEPLGDTTgWLGL-AFNDAPLAGEPVTIIGYP------------------GDRP-------- 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 621 lkKKVTRDMICAGEKEGGK------DACAGDSGGPMvtLNRERGQWYLVGTVSWGDDcgkkDRYGVYSYIhhNKDWIQRV 694
Cdd:COG3591  119 --KDLSLDCSGRVTGVQGNrlsydcDTTGGSSGSPV--LDDSDGGGRVVGVHSAGGA----DRANTGVRL--TSAIVAAL 188


                 ....*
gi 795477813 695 TRLRN 699
Cdd:COG3591  189 RAWAS 193
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 301-362 8.40e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.54  E-value: 8.40e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 795477813   301 CPELQPPVHGKIEPSQAKYSFKDQVLISCDTGYKVLKDNVemdtfqIECLKDGTWSNKIPTC 362
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSST------ITCLENGTWSPPPPTC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 153-181 1.50e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 1.50e-08
                          10        20
                  ....*....|....*....|....*....
gi 795477813  153 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 181
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA02639 PHA02639
EEV host range protein; Provisional
 300-433 9.83e-07

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 51.20  E-value: 9.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 300 ECPELQPPVHGKIEPSQAKYSFKDQVLISCDTGYKVLKDNVEMDtfQIECLKDGTWSNKIPTCKIVDCRAPGeLEHGLVT 379
Cdd:PHA02639  84 ECNDPPSIINGKIYNKREMYKVGDEIYYVCNEHKGVQYSLVGNE--KITCIQDKSWKPDPPICKMINCRFPA-LQNGYIN 160

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 795477813 380 FSTRNNLTTYKSEIRYSCQEPYYKMLNNITgiyTCSAQGVWMNkvlgrSLPTCL 433
Cdd:PHA02639 161 GIPSNKKFYYKTRVGFSCKSGFDLVGEKYS---TCNINATWFP-----SIPTCV 206
PHA02817 PHA02817
EEV Host range protein; Provisional
 306-401 1.23e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 46.86  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 306 PP--VHGKIEPSQAKYSFKDQVLISCDTG-----YKVLKDNVemdtfqIECLKDGTWSNKIPTCKIVDCRAPGeLEHGLV 378
Cdd:PHA02817  27 PPsiKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKN------IICEKDGKWNKEFPVCKIIRCRFPA-LQNGFV 99

                         90       100
                 ....*....|....*....|...
gi 795477813 379 TFSTRNNLTTYKSEIRYSCQEPY 401
Cdd:PHA02817 100 NGIPDSKKFYYESEVSFSCKPGF 122
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 279-382 2.36e-05

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 47.00  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 279 FHSDNSGENRGWRLSYRAAGNECPELQPPvHGKIEPSQAKYSFKDQVLISCDTGYKVLKDNVemdtfqIECLKDgTWsNK 358
Cdd:PHA02954 108 FRCEEKNGNTSWNDTVTCPNAECQPLQLE-HGSCQPVKEKYSFGEHITINCDVGYEVIGASY------ISCTAN-SW-NV 178

                         90       100
                 ....*....|....*....|....
gi 795477813 359 IPTCKiVDCRAPgELEHGLVTFST 382
Cdd:PHA02954 179 IPSCQ-QKCDIP-SLSNGLISGST 200
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 367-432 3.59e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 41.68  E-value: 3.59e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795477813 367 CRAPGELEHGLVTFSTRNnlTTYKSEIRYSCqEPYYKMLNNitGIYTCSAQGVWMNkvlgrSLPTC 432
Cdd:cd00033    1 CPPPPVPENGTVTGSKGS--YSYGSTVTYSC-NEGYTLVGS--STITCTENGGWSP-----PPPTC 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
139-181 4.80e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 4.80e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 795477813   139 DVDECKEREDeelsCDH--YCHNYIGGYYCSCRFGYilhTDNRTC 181
Cdd:smart00179   1 DIDECASGNP----CQNggTCVNTVGSYRCECPPGY---TDGRNC 38
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 367-432 6.67e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.97  E-value: 6.67e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795477813   367 CRAPGELEHGLVTFSTRNnlTTYKSEIRYSCQEPYYKMLNNITgiyTCSAQGVWMNkvlgrSLPTC 432
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT--YSYGDTVTYSCDPGYTLIGSSTI---TCLENGTWSP-----PPPTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 139-176 1.95e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 1.95e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 795477813 139 DVDECKEREdeelSCDHY--CHNYIGGYYCSCRFGYILHT 176
Cdd:cd00054    1 DIDECASGN----PCQNGgtCVNTVGSYRCSCPPGYTGRN 36
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 289-450 7.58e-04

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 41.95  E-value: 7.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 289 GWRLSYRAAGNECPELQPPVHGKIEPSQAkySFKDQVLISCDTGYKVLKDNveMDTFQIECLKDGTWSNKIPTCKIVDCR 368
Cdd:PHA02927  74 GWTLFNQCIKRRCPSPRDIDNGQLDIGGV--DFGSSITYSCNSGYQLIGES--KSYCELGSTGSMVWNPEAPICESVKCQ 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 369 APGELEHGlvTFSTRNNLTTYKSEIRYSCQEPYYKMLNniTGIyTCSAqGVWMNKvlgrslPTCLPV-CGLPKFSRKLMA 447
Cdd:PHA02927 150 SPPSISNG--RHNGYEDFYTDGSVVTYSCNSGYSLIGN--SGV-LCSG-GEWSDP------PTCQIVkCPHPTISNGYLS 217


                 ...
gi 795477813 448 RIF 450
Cdd:PHA02927 218 SGF 220
HMG-box_SOX cd22004
high mobility group (HMG)-box found in sex-determining region Y (SRY)-box (SOX) family ...
 499-544 2.59e-03

high mobility group (HMG)-box found in sex-determining region Y (SRY)-box (SOX) family transcription factors; The SOX gene family of transcription factors are characterized by the evolutionarily conserved SRY-type HMG box, which is a DNA binding domain that binds the minor groove of DNA on a common consensus site, (A/T)(A/T)CAA(A/T)G but with different levels of efficiency. Members include SRY and its homologs identified in mammals that can be subdivided into 8 groups (A, B1, B2, C, D, E, F, G, H). They are involved in embryonic development, regulating processes such as cell differentiation, maintenance of stemness, sex determination, and development of the central nervous, haematopoietic and other organ systems. The SOX gene family has a crucial role in carcinogenesis and cancer progression.


Pssm-ID: 438820 [Multi-domain]  Cd Length: 75  Bit Score: 37.14  E-value: 2.59e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 795477813 499 EDPTLRNSDLlspSDfkiILGKHWRLRSDENEQ-------HLRVKHITLHPQY 544
Cdd:cd22004   23 QNPKLHNSEI---SK---ILGKEWKKLTEEEKRpyveeaeRLREEHKKEYPDY 69
EGF_CA pfam07645
Calcium-binding EGF domain;
139-171 4.84e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 34.91  E-value: 4.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 795477813  139 DVDECkerEDEELSCDH--YCHNYIGGYYCSCRFG 171
Cdd:pfam07645   1 DVDEC---ATGTHNCPAntVCVNTIGSFECRCPDG 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 121-180 5.93e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 38.91  E-value: 5.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 121 DFSNEERFTGFDAHYMAVDVDECKEredEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
Cdd:cd01475  168 DFSTIEELTKKFQGKICVVPDLCAT---LSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
PHA02831 PHA02831
EEV host range protein; Provisional
 308-433 6.50e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 39.21  E-value: 6.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795477813 308 VHGKIEPSQAKYSFKDQVLISCDTGYKVLKDNVEMDTfqIECLkDGTWSNKIPTCKIVDCRAPGeLEHGLV-TFSTRnnl 386
Cdd:PHA02831  85 LNGYIKNKKDQYSFGDSVTYACKVNKLEKYSIVGNET--VKCI-NKQWVPKYPVCKLIRCKYPA-LQNGFLnVFEKK--- 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 795477813 387 TTYKSEIRYSCQEPyYKMLNNITGiyTCSAQGVWMNkvlgrSLPTCL 433
Cdd:PHA02831 158 FYYGDIVNFKCKKG-FILLGSSVS--TCDINSIWYP-----GIPKCV 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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