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Conserved domains on  [gi|795446334|ref|XP_011886174|]
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PREDICTED: CD177 antigen isoform X3 [Cercocebus atys]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TFP_LU_ECD_CD177_rpt1 cd23623
first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
47-145 4.68e-49

first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


:

Pssm-ID: 467143  Cd Length: 100  Bit Score: 163.64  E-value: 4.68e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795446334  47 LLCQLGTLKEVWNVSQLPVHWTPKEISCDSGLGCQDTMVLIESGPQVSLVLSKGCTEAKDQEPRITEHRMGPGLSVLSYT 126
Cdd:cd23623    2 LTCQKGTLETVRNVSELPLWWTAGQKTCEAGEGCQDTLMLIENGPQVNLVLIKGCTQAEDQEPRVTQHRAGPGLSIVSYT 81
                         90
                 ....*....|....*....
gi 795446334 127 YVCRHKDFCNNLVTTAPLW 145
Cdd:cd23623   82 RVCRHQDLCNDLSSTLPLW 100
TFP_LU_ECD_CD177_rpt3 cd23624
third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
272-366 1.67e-48

third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


:

Pssm-ID: 467144  Cd Length: 102  Bit Score: 162.09  E-value: 1.67e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795446334 272 FLTCHRGNSLQKDDNLAQVPIEWTMSNTVMCEAGQVCQETLLLIDVGHTSTLVWSKGCSAVGAQNSQKTSIHSAPPGVLV 351
Cdd:cd23624    1 FLTCHQGVMVKFGSNLSKEPVEWTTSGTQICDAGEVCQETLLLIDVGPKSLLLGSKGCSKPGAQDSQKVSIHSGPPGILV 80
                         90
                 ....*....|....*
gi 795446334 352 ASYAHFCSSDLCNGA 366
Cdd:cd23624   81 ASYVHFCSSDLCNRA 95
TFP_LU_ECD_CD177_rpt2 cd23636
second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
153-228 8.92e-42

second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of CD177.


:

Pssm-ID: 467800  Cd Length: 77  Bit Score: 143.65  E-value: 8.92e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795446334 153 PGSLRCPVCLSMEGCPEGTTEEMCPKGTTHCYNGLLRFRGEGIFSNLRVQGCLPQPGCNLLNGTQEIGPVRMTENC 228
Cdd:cd23636    1 PGSLRCPVCLSTGSCPEAATLVPCPAGTTHCYSGVLRLRGGGISTNLKVQGCMPQPGCNLLNGTQTIGPISVSENC 76
TFP_LU_ECD_CD177_rpt4 cd23637
fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
384-461 9.25e-36

fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the fourth ECD domain of CD177.


:

Pssm-ID: 467801 [Multi-domain]  Cd Length: 77  Bit Score: 127.43  E-value: 9.25e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 795446334 384 PGDQQCLTCVQPFETCSSDSPVkTCPRGTTHCYDGYISLSGGGVTTTMGIQGCVAQPSSSLLKHTRQIGIFSVREKGD 461
Cdd:cd23637    1 PGDLQCPVCVNFFGSCSDPSTV-TCPKGTTHCYKGYIHLIGGGLSSTVNIQGCMAQPSSSLLNHTQNIGIFSVTENSE 77
 
Name Accession Description Interval E-value
TFP_LU_ECD_CD177_rpt1 cd23623
first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
47-145 4.68e-49

first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467143  Cd Length: 100  Bit Score: 163.64  E-value: 4.68e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795446334  47 LLCQLGTLKEVWNVSQLPVHWTPKEISCDSGLGCQDTMVLIESGPQVSLVLSKGCTEAKDQEPRITEHRMGPGLSVLSYT 126
Cdd:cd23623    2 LTCQKGTLETVRNVSELPLWWTAGQKTCEAGEGCQDTLMLIENGPQVNLVLIKGCTQAEDQEPRVTQHRAGPGLSIVSYT 81
                         90
                 ....*....|....*....
gi 795446334 127 YVCRHKDFCNNLVTTAPLW 145
Cdd:cd23623   82 RVCRHQDLCNDLSSTLPLW 100
TFP_LU_ECD_CD177_rpt3 cd23624
third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
272-366 1.67e-48

third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467144  Cd Length: 102  Bit Score: 162.09  E-value: 1.67e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795446334 272 FLTCHRGNSLQKDDNLAQVPIEWTMSNTVMCEAGQVCQETLLLIDVGHTSTLVWSKGCSAVGAQNSQKTSIHSAPPGVLV 351
Cdd:cd23624    1 FLTCHQGVMVKFGSNLSKEPVEWTTSGTQICDAGEVCQETLLLIDVGPKSLLLGSKGCSKPGAQDSQKVSIHSGPPGILV 80
                         90
                 ....*....|....*
gi 795446334 352 ASYAHFCSSDLCNGA 366
Cdd:cd23624   81 ASYVHFCSSDLCNRA 95
TFP_LU_ECD_CD177_rpt2 cd23636
second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
153-228 8.92e-42

second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of CD177.


Pssm-ID: 467800  Cd Length: 77  Bit Score: 143.65  E-value: 8.92e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795446334 153 PGSLRCPVCLSMEGCPEGTTEEMCPKGTTHCYNGLLRFRGEGIFSNLRVQGCLPQPGCNLLNGTQEIGPVRMTENC 228
Cdd:cd23636    1 PGSLRCPVCLSTGSCPEAATLVPCPAGTTHCYSGVLRLRGGGISTNLKVQGCMPQPGCNLLNGTQTIGPISVSENC 76
TFP_LU_ECD_CD177_rpt4 cd23637
fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
384-461 9.25e-36

fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the fourth ECD domain of CD177.


Pssm-ID: 467801 [Multi-domain]  Cd Length: 77  Bit Score: 127.43  E-value: 9.25e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 795446334 384 PGDQQCLTCVQPFETCSSDSPVkTCPRGTTHCYDGYISLSGGGVTTTMGIQGCVAQPSSSLLKHTRQIGIFSVREKGD 461
Cdd:cd23637    1 PGDLQCPVCVNFFGSCSDPSTV-TCPKGTTHCYKGYIHLIGGGLSSTVNIQGCMAQPSSSLLNHTQNIGIFSVTENSE 77
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
158-233 3.52e-06

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 44.84  E-value: 3.52e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 795446334  158 CPVCL--SMEGCPegtTEEMCPKGTTHCYNGLLRFRGEGIFSNLRVQGCLpQPGCN-LLNGTQEIGPVRMTENCKKKDF 233
Cdd:pfam00021   1 CYSCLgvSNEDCL---SEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCA-RSSCPrLLSDFINGGIISVSESCCQSDL 75
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
389-458 3.72e-03

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 36.36  E-value: 3.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 795446334  389 CLTCVQPFET-CSsdsPVKTCPRGTTHCYDGYISLSGGGVTTTMGIQGCVAQPSSSLLKHTRQIGIFSVRE 458
Cdd:pfam00021   1 CYSCLGVSNEdCL---SEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCARSSCPRLLSDFINGGIISVSE 68
 
Name Accession Description Interval E-value
TFP_LU_ECD_CD177_rpt1 cd23623
first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
47-145 4.68e-49

first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467143  Cd Length: 100  Bit Score: 163.64  E-value: 4.68e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795446334  47 LLCQLGTLKEVWNVSQLPVHWTPKEISCDSGLGCQDTMVLIESGPQVSLVLSKGCTEAKDQEPRITEHRMGPGLSVLSYT 126
Cdd:cd23623    2 LTCQKGTLETVRNVSELPLWWTAGQKTCEAGEGCQDTLMLIENGPQVNLVLIKGCTQAEDQEPRVTQHRAGPGLSIVSYT 81
                         90
                 ....*....|....*....
gi 795446334 127 YVCRHKDFCNNLVTTAPLW 145
Cdd:cd23623   82 RVCRHQDLCNDLSSTLPLW 100
TFP_LU_ECD_CD177_rpt3 cd23624
third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
272-366 1.67e-48

third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467144  Cd Length: 102  Bit Score: 162.09  E-value: 1.67e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795446334 272 FLTCHRGNSLQKDDNLAQVPIEWTMSNTVMCEAGQVCQETLLLIDVGHTSTLVWSKGCSAVGAQNSQKTSIHSAPPGVLV 351
Cdd:cd23624    1 FLTCHQGVMVKFGSNLSKEPVEWTTSGTQICDAGEVCQETLLLIDVGPKSLLLGSKGCSKPGAQDSQKVSIHSGPPGILV 80
                         90
                 ....*....|....*
gi 795446334 352 ASYAHFCSSDLCNGA 366
Cdd:cd23624   81 ASYVHFCSSDLCNRA 95
TFP_LU_ECD_CD177_rpt2 cd23636
second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
153-228 8.92e-42

second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of CD177.


Pssm-ID: 467800  Cd Length: 77  Bit Score: 143.65  E-value: 8.92e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795446334 153 PGSLRCPVCLSMEGCPEGTTEEMCPKGTTHCYNGLLRFRGEGIFSNLRVQGCLPQPGCNLLNGTQEIGPVRMTENC 228
Cdd:cd23636    1 PGSLRCPVCLSTGSCPEAATLVPCPAGTTHCYSGVLRLRGGGISTNLKVQGCMPQPGCNLLNGTQTIGPISVSENC 76
TFP_LU_ECD_CD177_rpt4 cd23637
fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
384-461 9.25e-36

fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the fourth ECD domain of CD177.


Pssm-ID: 467801 [Multi-domain]  Cd Length: 77  Bit Score: 127.43  E-value: 9.25e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 795446334 384 PGDQQCLTCVQPFETCSSDSPVkTCPRGTTHCYDGYISLSGGGVTTTMGIQGCVAQPSSSLLKHTRQIGIFSVREKGD 461
Cdd:cd23637    1 PGDLQCPVCVNFFGSCSDPSTV-TCPKGTTHCYKGYIHLIGGGLSSTVNIQGCMAQPSSSLLNHTQNIGIFSVTENSE 77
TFP_LU_ECD_LYPD4_rpt1_like cd23564
first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4) ...
47-145 1.28e-35

first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD. CD177 contains four ECD domains. This model corresponds to the first ECD domain of LYPD4 and TEX101, as well as first and third ECD domains of CD177.


Pssm-ID: 467094  Cd Length: 99  Bit Score: 127.93  E-value: 1.28e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795446334  47 LLCQLGTLKEVW-NVSQLPVHWTPKEISCDSGLGCQDTMVLIESGPQVSLVLSKGCTEAKDQEPRITEHRMGPGLSVLSY 125
Cdd:cd23564    1 LTCYRGTSLYVGaNLANEPNWTTSRNETCEAGEVCQETLLLIESGTQVLILGSKGCTPAGSQSSRVTEHVSPPGLIITSY 80
                         90       100
                 ....*....|....*....|
gi 795446334 126 TYVCRhKDFCNNLVTTAPLW 145
Cdd:cd23564   81 TRVCN-SDFCNNLSSTSPFL 99
TFP_LU_ECD_LYPD4_rpt1_like cd23564
first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4) ...
273-364 6.60e-32

first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD. CD177 contains four ECD domains. This model corresponds to the first ECD domain of LYPD4 and TEX101, as well as first and third ECD domains of CD177.


Pssm-ID: 467094  Cd Length: 99  Bit Score: 117.92  E-value: 6.60e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795446334 273 LTCHRGNSLQKDDNLAQVPiEWTMSNTVMCEAGQVCQETLLLIDVGHTSTLVWSKGCSAVGaQNSQKTSIHSAPPGVLVA 352
Cdd:cd23564    1 LTCYRGTSLYVGANLANEP-NWTTSRNETCEAGEVCQETLLLIESGTQVLILGSKGCTPAG-SQSSRVTEHVSPPGLIIT 78
                         90
                 ....*....|..
gi 795446334 353 SYAHFCSSDLCN 364
Cdd:cd23564   79 SYTRVCNSDFCN 90
TFP_LU_ECD_LYPD4_rpt2_like cd23633
second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4) ...
154-229 5.76e-25

second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). CD177 contains four ECD domains. The model corresponds to the second ECD domain of LYPD4 and TEX101, as well as second and fourth ECD domains of CD177.


Pssm-ID: 467797  Cd Length: 76  Bit Score: 97.76  E-value: 5.76e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 795446334 154 GSLRCPVCLSMEG-CPEGTTEEMCPKGTtHCYNGLLRFRGEGIFSNLRVQGCLPQPGCNLLNGTQEIGPVRMTENCK 229
Cdd:cd23633    1 GTLQCPVCLHFKGsCSSNSNLVLCPKNT-RCYTGDLEVRGGGLSATFSIKGCLAQSTKNLLNNQTSIGIFSVREILN 76
TFP_LU_ECD_LYPD4_rpt2_like cd23633
second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4) ...
385-459 2.19e-24

second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). CD177 contains four ECD domains. The model corresponds to the second ECD domain of LYPD4 and TEX101, as well as second and fourth ECD domains of CD177.


Pssm-ID: 467797  Cd Length: 76  Bit Score: 96.22  E-value: 2.19e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 795446334 385 GDQQCLTCVQPFETCSSDSPVKTCPRGTtHCYDGYISLSGGGVTTTMGIQGCVAQPSSSLLKHTRQIGIFSVREK 459
Cdd:cd23633    1 GTLQCPVCLHFKGSCSSNSNLVLCPKNT-RCYTGDLEVRGGGLSATFSIKGCLAQSTKNLLNNQTSIGIFSVREI 74
TFP_LU_ECD_TEX101_rpt2 cd23634
second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
154-236 7.91e-20

second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of TEX101.


Pssm-ID: 467798  Cd Length: 83  Bit Score: 83.58  E-value: 7.91e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795446334 154 GSLRCPVCLSMEGCPEGTTEeMCPKGTTHCYNGLLRFRGEGIFSNLRVQGCLPQPGCNLLNGTQEIGPVRMTENCKKKDF 233
Cdd:cd23634    1 TTLHCPTCVALGSCFSAPSL-PCPRGTTRCYQGRIQLTGGGISSDVEVKGCTTMIGCRLLGGIQTIGPIEVSEKCPRQSF 79

                 ...
gi 795446334 234 LQL 236
Cdd:cd23634   80 LQP 82
TFP_LU_ECD_CD177_rpt2 cd23636
second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
384-461 1.03e-19

second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of CD177.


Pssm-ID: 467800  Cd Length: 77  Bit Score: 83.18  E-value: 1.03e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 795446334 384 PGDQQCLTCVQPFEtCSSDSPVKTCPRGTTHCYDGYISLSGGGVTTTMGIQGCVAQPSSSLLKHTRQIGIFSVREKGD 461
Cdd:cd23636    1 PGSLRCPVCLSTGS-CPEAATLVPCPAGTTHCYSGVLRLRGGGISTNLKVQGCMPQPGCNLLNGTQTIGPISVSENCN 77
TFP_LU_ECD_CD177_rpt4 cd23637
fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
153-227 3.95e-19

fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the fourth ECD domain of CD177.


Pssm-ID: 467801 [Multi-domain]  Cd Length: 77  Bit Score: 81.59  E-value: 3.95e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795446334 153 PGSLRCPVCLSMEG-CPEgTTEEMCPKGTTHCYNGLLRFRGEGIFSNLRVQGCLPQPGCNLLNGTQEIGPVRMTEN 227
Cdd:cd23637    1 PGDLQCPVCVNFFGsCSD-PSTVTCPKGTTHCYKGYIHLIGGGLSSTVNIQGCMAQPSSSLLNHTQNIGIFSVTEN 75
TFP_LU_ECD_CD177_rpt1 cd23623
first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
273-364 3.74e-15

first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467143  Cd Length: 100  Bit Score: 71.19  E-value: 3.74e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795446334 273 LTCHRGnSLQKDDNLAQVPIEWTMSNTVmCEAGQVCQETLLLIDVGHTSTLVWSKGCSAVGAQNSQKTSiHSAPPGVLVA 352
Cdd:cd23623    2 LTCQKG-TLETVRNVSELPLWWTAGQKT-CEAGEGCQDTLMLIENGPQVNLVLIKGCTQAEDQEPRVTQ-HRAGPGLSIV 78
                         90
                 ....*....|...
gi 795446334 353 SYAHFC-SSDLCN 364
Cdd:cd23623   79 SYTRVCrHQDLCN 91
TFP_LU_ECD_TEX101_rpt1 cd23622
first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
273-364 6.63e-15

first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467142  Cd Length: 99  Bit Score: 70.46  E-value: 6.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795446334 273 LTCHRGNSLQKDDNlAQVPIEWTMSNTVMCEAGQVCQETLLLIDVGHTSTLVWSKGCsaVGAQNSQKTSI-HSAPPGVLV 351
Cdd:cd23622    1 LYCHKGISMTIEED-PRNTFNWTTEKVETCDNGTLCQETILMIKAGTKTAILATKGC--ISEGMEAVTFIqHTPPPGLVA 77
                         90
                 ....*....|...
gi 795446334 352 ASYAHFCSSDLCN 364
Cdd:cd23622   78 VSYSNYCEDSLCN 90
TFP_LU_ECD_CD177_rpt3 cd23624
third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
47-137 1.24e-14

third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467144  Cd Length: 102  Bit Score: 69.64  E-value: 1.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795446334  47 LLCQLGTLkeVW---NVSQLPVHWTPKEI-SCDSGLGCQDTMVLIESGPQVSLVLSKGCTEAKDQE-PRITEHRMGPGLS 121
Cdd:cd23624    2 LTCHQGVM--VKfgsNLSKEPVEWTTSGTqICDAGEVCQETLLLIDVGPKSLLLGSKGCSKPGAQDsQKVSIHSGPPGIL 79
                         90
                 ....*....|....*.
gi 795446334 122 VLSYTYVCrHKDFCNN 137
Cdd:cd23624   80 VASYVHFC-SSDLCNR 94
TFP_LU_ECD_TEX101_rpt2 cd23634
second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
388-465 5.95e-14

second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of TEX101.


Pssm-ID: 467798  Cd Length: 83  Bit Score: 67.02  E-value: 5.95e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 795446334 388 QCLTCVQPFeTCSSDSPVkTCPRGTTHCYDGYISLSGGGVTTTMGIQGCVAQPSSSLLKHTRQIGIFSVREKGDSESG 465
Cdd:cd23634    4 HCPTCVALG-SCFSAPSL-PCPRGTTRCYQGRIQLTGGGISSDVEVKGCTTMIGCRLLGGIQTIGPIEVSEKCPRQSF 79
TFP_LU_ECD_TEX101_rpt1 cd23622
first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
47-145 2.00e-13

first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467142  Cd Length: 99  Bit Score: 66.22  E-value: 2.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795446334  47 LLCQLGTLKEVWNVSQLPVHWTPKEI-SCDSGLGCQDTMVLIESGPQVSLVLSKGCTEAKDQEPRITEHRMGPGLSVLSY 125
Cdd:cd23622    1 LYCHKGISMTIEEDPRNTFNWTTEKVeTCDNGTLCQETILMIKAGTKTAILATKGCISEGMEAVTFIQHTPPPGLVAVSY 80
                         90       100
                 ....*....|....*....|
gi 795446334 126 TYVCRHKdFCNNLVTTAPLW 145
Cdd:cd23622   81 SNYCEDS-LCNNKKSLSSFW 99
TFP_LU_ECD_LYPD4_rpt1 cd23621
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and ...
293-364 1.50e-08

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and similar proteins; LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. LYPD4 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467141  Cd Length: 103  Bit Score: 52.55  E-value: 1.50e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 795446334 293 EWTMSNTVMCEAGQVCQETLLLIDVGHTSTLVWSKGCSAVgAQNSQKTSIHSAPPGVLVASYAHFCSSDLCN 364
Cdd:cd23621   21 KWLLMRSMVCKLNEGCEETLVFIETGTARGVVGFKGCSPA-SSYPPQISYLVSPPGVSIASYSRVCRSYLCN 91
TFP_LU_ECD_LYPD4_rpt1 cd23621
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and ...
74-144 1.38e-07

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and similar proteins; LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. LYPD4 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467141  Cd Length: 103  Bit Score: 49.47  E-value: 1.38e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 795446334  74 CDSGLGCQDTMVLIESGPQVSLVLSKGCTEAKDQEPRITEHRMGPGLSVLSYTYVCRHKdFCNNLVTTAPL 144
Cdd:cd23621   30 CKLNEGCEETLVFIETGTARGVVGFKGCSPASSYPPQISYLVSPPGVSIASYSRVCRSY-LCNNLTNMEPF 99
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
158-233 3.52e-06

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 44.84  E-value: 3.52e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 795446334  158 CPVCL--SMEGCPegtTEEMCPKGTTHCYNGLLRFRGEGIFSNLRVQGCLpQPGCN-LLNGTQEIGPVRMTENCKKKDF 233
Cdd:pfam00021   1 CYSCLgvSNEDCL---SEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCA-RSSCPrLLSDFINGGIISVSESCCQSDL 75
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
384-437 5.95e-05

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 41.67  E-value: 5.95e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 795446334 384 PGDQQCLTCV-QPFETCS-SDSPVKTCPRGTTHCYDGYISLSGGGVTTTMGIQGCV 437
Cdd:cd23563    1 PNGVECYSCVgNSRGACSpSNAPVVRCYGAYSGCFDGNVTLTIGNVTLSLPVKGCV 56
TFP_LU_ECD_LYPD4_rpt2 cd23635
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and ...
158-226 6.42e-04

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and similar proteins; LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. LYPD4 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and shows snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD domain of LYPD4.


Pssm-ID: 467799  Cd Length: 88  Bit Score: 38.69  E-value: 6.42e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 795446334 158 CPVCLS--MEGC-PEGTTEEMCPKGTTHCYNGLLRFRGEGIFSNLRVQGCLPQPGcNLLNGTQEIGPVRMTE 226
Cdd:cd23635    5 CPTCVGrhTKEClPSFVSSESCPCAASTCYSSTLKFQAGFLNTTFLLMGCAREQH-KLLADFQHIGSIRVTE 75
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
389-458 3.72e-03

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 36.36  E-value: 3.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 795446334  389 CLTCVQPFET-CSsdsPVKTCPRGTTHCYDGYISLSGGGVTTTMGIQGCVAQPSSSLLKHTRQIGIFSVRE 458
Cdd:pfam00021   1 CYSCLGVSNEdCL---SEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCARSSCPRLLSDFINGGIISVSE 68
TFP_LU_ECD_LYPD4_rpt2 cd23635
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and ...
387-458 4.29e-03

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and similar proteins; LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. LYPD4 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and shows snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD domain of LYPD4.


Pssm-ID: 467799  Cd Length: 88  Bit Score: 36.38  E-value: 4.29e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 795446334 387 QQCLTCVQPFETCSSDSPV--KTCPRGTTHCYDGYISLSGGGVTTTMGIQGCvAQPSSSLLKHTRQIGIFSVRE 458
Cdd:cd23635    3 HSCPTCVGRHTKECLPSFVssESCPCAASTCYSSTLKFQAGFLNTTFLLMGC-AREQHKLLADFQHIGSIRVTE 75
TFP_LU_ECD_LYPD3_rpt1 cd23562
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
298-364 9.08e-03

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467092  Cd Length: 87  Bit Score: 35.41  E-value: 9.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 795446334 298 NTVMC-EAGQVCQETLLLIDVGHTSTLVWSKGCSA-VGAQNSQKTSIHsappGVLVASYAHFCSSDLCN 364
Cdd:cd23562   20 TTVSCaPPMNVCTEYVAAVKTSHGTLTLRKKGCGSgLPGKLDRGLTLH----GLYAFIQLRACNTSLCN 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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