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Conserved domains on  [gi|795276398|ref|XP_011813118|]
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PREDICTED: uncharacterized protein LOC105523014 isoform X1 [Colobus angolensis palliatus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 18-407 1.24e-132

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 402.78  E-value: 1.24e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  18 LLLINLLTFGLEVCLAAGITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDHWRGRYGRRRPFIWALSLGIL 97
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  98 LSLFLIPRAGWLAGLLCPDPRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHcRQAYSVYAFMISLGGCLGYL 177
Cdd:cd17313   81 LGLILIPNAADIGLALGDGPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQR-SKANGIINFMGGLGGVLGYL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 178 LPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVAEEAALGPTEPAEGLSAPslpshccpcwarlafrnLGALL 257
Cdd:cd17313  160 LGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS-----------------LGEVL 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 258 PRLHQLCCRMPRTLRRLFVAELCSWMALMTFTLFYTDFVGEGLYQGvpraelGTEARRHYDEGVRMGSLGLFLQCAISLV 337
Cdd:cd17313  223 KSLLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLI 296

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 338 FSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLASLYHRER 407
Cdd:cd17313  297 FSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSES 366
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 456-527 1.65e-39

erythroblast transformation specific domain; variation of the helix-turn-helix motif


:

Pssm-ID: 197710  Cd Length: 87  Bit Score: 140.87  E-value: 1.65e-39
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795276398   456 KPQNKHMICWTSND-GQFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYP 527
Cdd:smart00413  14 DPENSDIIKWTDRDeGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVYKFVKNP 86
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 606-830 6.45e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 6.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  606 KTENPAEKLAEKKSPQEPTP--------SVIKFVTTPSKKPPVEPVVATISTGPSISPSSEETIQAletlvSPKLPSLEA 677
Cdd:PHA03247 2666 RARRLGRAAQASSPPQRPRRraarptvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQA-----SPALPAAPA 2740

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  678 PTSASNVTTVFAT-----TPPVSSIPPLQEPPRTPS---PPLSSHPDIDTDIDSVASQPmelaenLSLEPKDQDSVLPEK 749
Cdd:PHA03247 2741 PPAVPAGPATPGGparpaRPPTTAGPPAPAPPAAPAagpPRRLTRPAVASLSESRESLP------SPWDPADPPAAVLAP 2814

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  750 DKANNSSRSkkPKGLELAPTLVITSSDPSPLGILSPSLPT------------------ASLTPAFFSQTPIILTPSPLLS 811
Cdd:PHA03247 2815 AAALPPAAS--PAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdvrrrppsrsPAAKPAAPARPPVRRLARPAVS 2892

                         250       260
                  ....*....|....*....|
gi 795276398  812 SihfwSTLS-PVAPLSPARL 830
Cdd:PHA03247 2893 R----STESfALPPDQPERP 2908
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 18-407 1.24e-132

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 402.78  E-value: 1.24e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  18 LLLINLLTFGLEVCLAAGITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDHWRGRYGRRRPFIWALSLGIL 97
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  98 LSLFLIPRAGWLAGLLCPDPRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHcRQAYSVYAFMISLGGCLGYL 177
Cdd:cd17313   81 LGLILIPNAADIGLALGDGPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQR-SKANGIINFMGGLGGVLGYL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 178 LPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVAEEAALGPTEPAEGLSAPslpshccpcwarlafrnLGALL 257
Cdd:cd17313  160 LGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS-----------------LGEVL 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 258 PRLHQLCCRMPRTLRRLFVAELCSWMALMTFTLFYTDFVGEGLYQGvpraelGTEARRHYDEGVRMGSLGLFLQCAISLV 337
Cdd:cd17313  223 KSLLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLI 296

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 338 FSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLASLYHRER 407
Cdd:cd17313  297 FSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSES 366
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 456-527 1.65e-39

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 140.87  E-value: 1.65e-39
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795276398   456 KPQNKHMICWTSND-GQFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYP 527
Cdd:smart00413  14 DPENSDIIKWTDRDeGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVYKFVKNP 86
Ets pfam00178
Ets-domain;
457-523 1.24e-34

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 126.46  E-value: 1.24e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 795276398  457 PQNKHMICWTSND-GQFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKF 523
Cdd:pfam00178  13 PEYSDIIKWTDKEeGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYRF 80
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
17-399 4.06e-29

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 121.55  E-value: 4.06e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  17 QLLLINLLTFGLEVCLAAGITYVPPLLLEV-GVEEKFMTMVLGIGPVLGLVSVPLLGSASDHWRGRYGRRRPFIWALSLG 95
Cdd:COG2211   11 EKLAYGLGDLGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIGAIP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  96 ILLSLFLIPRAGWLAGllcpdprPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYSVYAFMISLGGCLG 175
Cdd:COG2211   91 LALSFVLLFTAPDLSP-------TGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 176 YLLPAIdwdtsaLAPYLGTQEE----CLFGLLTLIFLTCVAATLLVAEEAALGPTEPAEGLSApslpshccpcwARLAFR 251
Cdd:COG2211  164 SVLPPP------LVAAFGGDAAlgyrLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKES-----------LKALLK 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 252 NlgallprlhqlccrmpRTLRRLFVAELCSWMALM---TFTLFYTDFVgeglyqgvpraeLGTEArrhydegvRMGSLGL 328
Cdd:COG2211  227 N----------------RPFLLLLLAYLLFFLALAlvaALLLYYFKYV------------LGLSA--------ALVGLLL 270

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795276398 329 FLQCAISLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLS--HSVAVVTASAALTGFTFSALQILPYTL 399
Cdd:COG2211  271 ALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAM 343
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 32-403 5.44e-26

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 112.59  E-value: 5.44e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   32 LAAGITY--------VPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLI 103
Cdd:TIGR01301  12 VAAGVQFgwalqlslLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGAALVAFAVILI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  104 PRAGWLAGL----LCPDPRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFR-DPDHCRQAYSVYAFMISLGGCLGYLL 178
Cdd:TIGR01301  92 GFAADIGHLfgdnLDKKTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGgDARRTRIANAYFSFFMAIGNVLGYAA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  179 PAID-W-------DTSALAPYLGTQEECLfgLLTLIFLTCVAATLLVAEEAALGPTEPAEGLSAPSLPSH--CCPCWARL 248
Cdd:TIGR01301 172 GAYSgLykifpftKTEACGVSCANLKSCF--LIDIILLAILTYIALSAVKENPLIGSDDFINSEAAPPSKhgEEAFFGEL 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  249 --AFRNLgallprlhqlccrmPRTLRRLFVAELCSWMALMTFTLFYTDFVGEGLYQGVPRAElgtearRHYDEGVRMGSL 326
Cdd:TIGR01301 250 fgAFKYL--------------PRPVWILLLVTCLNWIAWFPFILFDTDWMGREVYGGSVNQG------AKYDDGVRAGAF 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  327 GLFLQCAISLVFSLVMDRLVQRFGT-RAVYLASVAAFPVAAGATCLSHSVAV-----------------VTASA----AL 384
Cdd:TIGR01301 310 GLMLNSVVLGITSIGMEKLCRGWGAgKRLWGIVNIILAICLAATVLVTYVAKnsryydgdgeslppptgIKASAlivfAI 389

                         410
                  ....*....|....*....
gi 795276398  385 TGFTFSALQILPYTLASLY 403
Cdd:TIGR01301 390 LGIPLAITYSIPFALASIR 408
MFS_1 pfam07690
Major Facilitator Superfamily;
18-407 6.97e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 67.83  E-value: 6.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   18 LLLINLLTFGLEVCLaaGITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRPFIWALSLGIL 97
Cdd:pfam07690   1 LFLAAFLAALGRSLL--GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD----RFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   98 LSLFLIPRAGWLagllcpdprplelaLLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRqAYSVYAFMISLGGCLGYL 177
Cdd:pfam07690  75 GLLLLLFASSLW--------------LLLVLRVLQGLGAGALFPAALALIADWFPPEERGR-ALGLVSAGFGLGAALGPL 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  178 LpaidwdTSALAPYLGTQEecLFGLLTLIFLTCVAATLLVAEEAALGPTEPAEGLSAPSLpshccpcWARLAFRNLGALL 257
Cdd:pfam07690 140 L------GGLLASLFGWRA--AFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI-------VAWKALLRDPVLW 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  258 prlhqlccrmprtlrrLFVAELCSWMALMTFTLFYTdfvgegLYQGVpraelgtearrhYDEGVRMGSLGLFLQCAISLV 337
Cdd:pfam07690 205 ----------------LLLALLLFGFAFFGLLTYLP------LYQEV------------LGLSALLAGLLLGLGGLLGAI 250

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795276398  338 FSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCL---SHSVAVVTASAALTGFTFSALQILPYTLASLYHRER 407
Cdd:pfam07690 251 GRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLlslTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKE 323
PHA03247 PHA03247
large tegument protein UL36; Provisional
 606-830 6.45e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 6.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  606 KTENPAEKLAEKKSPQEPTP--------SVIKFVTTPSKKPPVEPVVATISTGPSISPSSEETIQAletlvSPKLPSLEA 677
Cdd:PHA03247 2666 RARRLGRAAQASSPPQRPRRraarptvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQA-----SPALPAAPA 2740

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  678 PTSASNVTTVFAT-----TPPVSSIPPLQEPPRTPS---PPLSSHPDIDTDIDSVASQPmelaenLSLEPKDQDSVLPEK 749
Cdd:PHA03247 2741 PPAVPAGPATPGGparpaRPPTTAGPPAPAPPAAPAagpPRRLTRPAVASLSESRESLP------SPWDPADPPAAVLAP 2814

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  750 DKANNSSRSkkPKGLELAPTLVITSSDPSPLGILSPSLPT------------------ASLTPAFFSQTPIILTPSPLLS 811
Cdd:PHA03247 2815 AAALPPAAS--PAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdvrrrppsrsPAAKPAAPARPPVRRLARPAVS 2892

                         250       260
                  ....*....|....*....|
gi 795276398  812 SihfwSTLS-PVAPLSPARL 830
Cdd:PHA03247 2893 R----STESfALPPDQPERP 2908
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 644-808 3.53e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.60  E-value: 3.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  644 VATISTGPS---ISPSSEETIQALETLVSPKLPSlEAPTSASNVTTVFATTPPVSSIPPLQEPPRTPSPPLSSHPDIDTd 720
Cdd:pfam05109 393 VSGLGTAPKtliITRTATNATTTTHKVIFSKAPE-STTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVST- 470

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  721 IDSVASQPMELAENLSL-----EPKDQDSVLPEKDKANNSSRSKKPKGLELAPTLVITSSDP---SP-LGILSPSLPTAS 791
Cdd:pfam05109 471 ADVTSPTPAGTTSGASPvtpspSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPnatSPtLGKTSPTSAVTT 550

                         170
                  ....*....|....*..
gi 795276398  792 LTPAFFSQTPIILTPSP 808
Cdd:pfam05109 551 PTPNATSPTPAVTTPTP 567
Not5 COG5665
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
620-804 4.84e-03

CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];


Pssm-ID: 444384 [Multi-domain]  Cd Length: 874  Bit Score: 40.80  E-value: 4.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 620 PQEPTPSVIKFVTTPSKKPPVEPVVATISTGPSISPSS---EETIQALETLVSPK--LPSLEAPTSASNV----TTVFAT 690
Cdd:COG5665  334 ASVPTTEETTAFTTPSSVPSTPAEKDTPATDLATPVSPtppETSVDKKVSPDSATssTKSEKEGGTASSPmppnIAIGAK 413

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 691 TPPVSSIPPLQEPPRTPSPPLSshPDIDTDIDSVASQPMELAENLSLEPKDQdsvLPEKDKANNSSRSKKPKGLELAPTL 770
Cdd:COG5665  414 DDVDATDPSQEAKEYTKNAPMT--PEADSAPESSVRTEASPSAGSDLEPENT---TLRDPAPNAIPPPEDPSTIGRLSSG 488

                        170       180       190
                 ....*....|....*....|....*....|....
gi 795276398 771 VITSSDPSPLGILSPSLPTASLTPAFFSQTPIIL 804
Cdd:COG5665  489 DKLANETGPPVIRRDSTPSSTADQSIVGVLAFGL 522
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 18-407 1.24e-132

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 402.78  E-value: 1.24e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  18 LLLINLLTFGLEVCLAAGITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDHWRGRYGRRRPFIWALSLGIL 97
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  98 LSLFLIPRAGWLAGLLCPDPRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHcRQAYSVYAFMISLGGCLGYL 177
Cdd:cd17313   81 LGLILIPNAADIGLALGDGPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQR-SKANGIINFMGGLGGVLGYL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 178 LPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVAEEAALGPTEPAEGLSAPslpshccpcwarlafrnLGALL 257
Cdd:cd17313  160 LGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS-----------------LGEVL 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 258 PRLHQLCCRMPRTLRRLFVAELCSWMALMTFTLFYTDFVGEGLYQGvpraelGTEARRHYDEGVRMGSLGLFLQCAISLV 337
Cdd:cd17313  223 KSLLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLI 296

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 338 FSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLASLYHRER 407
Cdd:cd17313  297 FSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSES 366
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 456-527 1.65e-39

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 140.87  E-value: 1.65e-39
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795276398   456 KPQNKHMICWTSND-GQFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYP 527
Cdd:smart00413  14 DPENSDIIKWTDRDeGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVYKFVKNP 86
Ets pfam00178
Ets-domain;
457-523 1.24e-34

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 126.46  E-value: 1.24e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 795276398  457 PQNKHMICWTSND-GQFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKF 523
Cdd:pfam00178  13 PEYSDIIKWTDKEeGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYRF 80
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
17-399 4.06e-29

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 121.55  E-value: 4.06e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  17 QLLLINLLTFGLEVCLAAGITYVPPLLLEV-GVEEKFMTMVLGIGPVLGLVSVPLLGSASDHWRGRYGRRRPFIWALSLG 95
Cdd:COG2211   11 EKLAYGLGDLGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIGAIP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  96 ILLSLFLIPRAGWLAGllcpdprPLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYSVYAFMISLGGCLG 175
Cdd:COG2211   91 LALSFVLLFTAPDLSP-------TGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 176 YLLPAIdwdtsaLAPYLGTQEE----CLFGLLTLIFLTCVAATLLVAEEAALGPTEPAEGLSApslpshccpcwARLAFR 251
Cdd:COG2211  164 SVLPPP------LVAAFGGDAAlgyrLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKES-----------LKALLK 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 252 NlgallprlhqlccrmpRTLRRLFVAELCSWMALM---TFTLFYTDFVgeglyqgvpraeLGTEArrhydegvRMGSLGL 328
Cdd:COG2211  227 N----------------RPFLLLLLAYLLFFLALAlvaALLLYYFKYV------------LGLSA--------ALVGLLL 270

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795276398 329 FLQCAISLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLS--HSVAVVTASAALTGFTFSALQILPYTL 399
Cdd:COG2211  271 ALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAM 343
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 32-403 5.44e-26

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 112.59  E-value: 5.44e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   32 LAAGITY--------VPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLI 103
Cdd:TIGR01301  12 VAAGVQFgwalqlslLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGAALVAFAVILI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  104 PRAGWLAGL----LCPDPRPLELALLILGVGLLDFCGQVCFTPLEALLSDLFR-DPDHCRQAYSVYAFMISLGGCLGYLL 178
Cdd:TIGR01301  92 GFAADIGHLfgdnLDKKTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGgDARRTRIANAYFSFFMAIGNVLGYAA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  179 PAID-W-------DTSALAPYLGTQEECLfgLLTLIFLTCVAATLLVAEEAALGPTEPAEGLSAPSLPSH--CCPCWARL 248
Cdd:TIGR01301 172 GAYSgLykifpftKTEACGVSCANLKSCF--LIDIILLAILTYIALSAVKENPLIGSDDFINSEAAPPSKhgEEAFFGEL 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  249 --AFRNLgallprlhqlccrmPRTLRRLFVAELCSWMALMTFTLFYTDFVGEGLYQGVPRAElgtearRHYDEGVRMGSL 326
Cdd:TIGR01301 250 fgAFKYL--------------PRPVWILLLVTCLNWIAWFPFILFDTDWMGREVYGGSVNQG------AKYDDGVRAGAF 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  327 GLFLQCAISLVFSLVMDRLVQRFGT-RAVYLASVAAFPVAAGATCLSHSVAV-----------------VTASA----AL 384
Cdd:TIGR01301 310 GLMLNSVVLGITSIGMEKLCRGWGAgKRLWGIVNIILAICLAATVLVTYVAKnsryydgdgeslppptgIKASAlivfAI 389

                         410
                  ....*....|....*....
gi 795276398  385 TGFTFSALQILPYTLASLY 403
Cdd:TIGR01301 390 LGIPLAITYSIPFALASIR 408
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
8-401 1.29e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 85.41  E-value: 1.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   8 SRLLRHRKAQLLLINLLTFGLEVCLAAGITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRP 87
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD----RFGRRRV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  88 FIWALSLGILlslflipraGWLAGLLCPDprpleLALLILGVGLLDFCGQVCFTPLEALLSDLFrDPDHCRQAYSVYAFM 167
Cdd:COG2814   78 LLLGLLLFAL---------GSLLCALAPS-----LWLLLAARFLQGLGAGALFPAALALIADLV-PPERRGRALGLLGAG 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 168 ISLGGCLGYLLpaidwdTSALAPYLGTQEecLFGLLTLIFLTCVAATLLVAEEAAlgPTEPAEGLSApslpshccpcwAR 247
Cdd:COG2814  143 LGLGPALGPLL------GGLLADLFGWRW--VFLVNAVLALLALLLLLRLLPESR--PAARARLRGS-----------LR 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 248 LAFRNlgallprlhqlccrmpRTLRRLFVAELCSWMALMTFTLFYTDFVGEGLyqGVPRAELGtearrhydegvrmgsLG 327
Cdd:COG2814  202 ELLRR----------------PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL--GLSASAAG---------------LL 248

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 795276398 328 LFLQCAISLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLAS 401
Cdd:COG2814  249 LALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 18-408 1.43e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 85.56  E-value: 1.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  18 LLLINLLTFGLEVCLAagiTYVPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRPFIWALSLGIL 97
Cdd:cd06174    1 LLLGFFLTGLARGLIS---PLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD----RFGRRPVLLLGLLLFAL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  98 LSLFLipragWLAGLlcpdprpleLALLILGVGLLDFCGQVCFTPLEALLSDLFrDPDHCRQAYSVYAFMISLGGCLGYL 177
Cdd:cd06174   74 GALLF-----AFAPS---------FWLLLLGRFLLGLGSGLIDPAVLALIADLF-PERERGRALGLLQAFGSVGGILGPL 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 178 LpaidwdTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVAEEAALGPTEPAEGLSAPSLPSHccpcwARLAFRNLGALL 257
Cdd:cd06174  139 L------GGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL-----LKRVLKNPGLWL 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 258 prlhqlccrmprtlrrLFVAELCSWMALMTFTLFYTDFVGEGLYQGVpraelgtearrhyDEGVRMGSLGLFLQCAISLV 337
Cdd:cd06174  208 ----------------LLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV-------------AVAGLLLSLFGLAGALGSLL 258

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 795276398 338 FSLVMDRLvqrFGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLASLYHRERQ 408
Cdd:cd06174  259 LGLLSDRL---IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEI 326
MFS_1 pfam07690
Major Facilitator Superfamily;
18-407 6.97e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 67.83  E-value: 6.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   18 LLLINLLTFGLEVCLaaGITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRPFIWALSLGIL 97
Cdd:pfam07690   1 LFLAAFLAALGRSLL--GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD----RFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   98 LSLFLIPRAGWLagllcpdprplelaLLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRqAYSVYAFMISLGGCLGYL 177
Cdd:pfam07690  75 GLLLLLFASSLW--------------LLLVLRVLQGLGAGALFPAALALIADWFPPEERGR-ALGLVSAGFGLGAALGPL 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  178 LpaidwdTSALAPYLGTQEecLFGLLTLIFLTCVAATLLVAEEAALGPTEPAEGLSAPSLpshccpcWARLAFRNLGALL 257
Cdd:pfam07690 140 L------GGLLASLFGWRA--AFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI-------VAWKALLRDPVLW 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  258 prlhqlccrmprtlrrLFVAELCSWMALMTFTLFYTdfvgegLYQGVpraelgtearrhYDEGVRMGSLGLFLQCAISLV 337
Cdd:pfam07690 205 ----------------LLLALLLFGFAFFGLLTYLP------LYQEV------------LGLSALLAGLLLGLGGLLGAI 250

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795276398  338 FSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCL---SHSVAVVTASAALTGFTFSALQILPYTLASLYHRER 407
Cdd:pfam07690 251 GRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLlslTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKE 323
MFS_1 pfam07690
Major Facilitator Superfamily;
9-175 9.54e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 61.28  E-value: 9.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398    9 RLLRHRKAQLLLINLLTFGLevCLAAGITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRPF 88
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGF--AFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD----RLGRRRRL 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   89 IWALSLGILLSLFLIPRAGWLAGLLcpdprpLELALLILGVGLLdfcgqVCFTPLEALLSDLFRdPDHCRQAYSVYAFMI 168
Cdd:pfam07690 269 LLALLLLILAALGLLLLSLTLSSLW------LLLALLLLGFGFG-----LVFPALNALVSDLAP-KEERGTASGLYNTAG 336


                  ....*..
gi 795276398  169 SLGGCLG 175
Cdd:pfam07690 337 SLGGALG 343
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 51-396 1.92e-09

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 60.70  E-value: 1.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  51 KFMTMVLGIGPVL--GLVSV---------PLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIpragWLAgllcPDPRP 119
Cdd:cd17332   24 FFYTDVLGLSAAAagTIFLVariidaindPLMGYLIDRTRSRWGRFRPWLLWGAIPLALLFVLL----FTT----PDGSG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 120 LELALLILGVGLLDFCGQVCFT-PLEALLSDLFRDPDHCRQAYSVYAFMISLGGCLGYLLPAIdwdtsaLAPYLGT--QE 196
Cdd:cd17332   96 TGKLIYALITYILLDLLYTLVNiPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPP------LVAYFGGgnAS 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 197 ECLFGLLTLIFLTCVAATLLVAEEAALGPTEPAEGLSAPSLPSHccpcwARLAFRNlgallprlhqlccrmpRTLRRLFV 276
Cdd:cd17332  170 RGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKS-----LKALLKN----------------RPFLILLL 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 277 AELCSWMALM---TFTLFYTDFVgeglyqGVPRAELgtearrhydegvrMGSLGLFLqcAISLVFSLVMDRLVQRFGTRA 353
Cdd:cd17332  229 AYLLYFLAFNivnTVLVYYFKYV------LGGRAEL-------------VLLLLLIL--SGALLALLPWPPLKKRFGKKK 287

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 795276398 354 VYLASVAAFPVAAGATCL--SHSVAVVTASAALTGFTFSALQILP 396
Cdd:cd17332  288 AFFIGLLLAILGLLLLFFlpPGNLVLILVLAVLAGIGYGGANLLP 332
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 37-396 4.15e-09

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 59.63  E-value: 4.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   37 TYVPPLLLEV-GVEEKFMTMVLGIGPVLGLVSVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIpragWLAGLLCP 115
Cdd:pfam13347  18 TYLLYFYTDVlGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAVSFILL----FTPPELGR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  116 DPRPLELALLILGVGLLDFCGQVCFTpleALLSDLFRDPDHcRQAYSVYAFMIS-LGGCLGYLLPAIdwdtsALAPYLGT 194
Cdd:pfam13347  94 APLFIWLLATYILLRIAYTFFEIPYW---SLGPELTRDYDE-RTSLTSYRSFFSvGGGLLAAALAFP-----LVLILGGT 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  195 QEEC----LFGLL--TLIFLTCVAATLLVAEEAALGPTEPAEGLSAPSLpshccpcwarlaFRNLGALLprlhqlccRMp 268
Cdd:pfam13347 165 GLERkgyrIFALIgaVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSL------------LDMLKEVF--------RN- 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  269 RTLRRLFVAELCSWMAL-MTFTL---FYTDFVGEGlyqgvpraelgtearrhydegvRMGSLGLFLQCAISLVFSLVMDR 344
Cdd:pfam13347 224 RAFLILLASFLLAALAMgVLNGLllyYFRYVLGNG----------------------FAASAFPLVFTIGALLGIPLWPP 281

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 795276398  345 LVQRFGTRAVYLAS-VAAFPVAAGATCLS-HSVAVVTASAALTGFTFSALQILP 396
Cdd:pfam13347 282 LAKRIGKKNTYILGaLITIAGFALALLLGpNNTLLFLVLYIIIGFGYGSSFFLP 335
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-216 1.15e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 57.97  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   1 MVQRLWVSRLLRHRKAQLLLINLLTFGLEVCLAAGITYVPPLLLEV-GVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwr 79
Cdd:cd17325  184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSD--- 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  80 gRYGRRRPFIWALsLGILLSLFLIPRAGWLAGLLcpdprpleLALLILGVGLldfcgQVCFTPLEALLSDLFrDPDHCRQ 159
Cdd:cd17325  261 -RIGRKPLILIGL-LLSAVALLLLPLATSFWLLL--------LLLALLGLGL-----GLVFPATLALLADIV-PPEGRGT 324

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 795276398 160 AYSVYAFMISLGGCLGYLLpaidwdTSALAPYLGTQEecLFGLLTLIFLTCVAATLL 216
Cdd:cd17325  325 AMGLFNTAFSLGMVLGPLL------GGFLYDAFGFAT--PFLAAAALLLLAAVLFLL 373
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
16-222 1.20e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 57.96  E-value: 1.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  16 AQLLLINLLTFGLEVCLAAGITYVPPLLLEV-GVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRpfIWALSL 94
Cdd:COG2271  180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD----RLGRRR--KLVLAI 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  95 GILLSLfliprAGWLAGLLCPDPrplelALLILGVGLLDFCGQVCFTPLEALLSDLFrdPDHCR-QAYSVYAFMISLGGC 173
Cdd:COG2271  254 GLLLAA-----LALLLLALLPSP-----ALAIALLFLAGFGLGGAFGLLWALAAELF--PKKARgTASGLVNTFGFLGGA 321

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 795276398 174 L-----GYLLPAIDWDTSalapylgtqeeclFGLLTLIFLTCVAATLLVAEEAA 222
Cdd:COG2271  322 LgpllvGYLLDATGYQAA-------------FLLLAALALLAALLALLLLRETR 362
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-405 1.39e-08

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 57.96  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   1 MVQRLWVSRLLRHRKAQLLLINLLTFGLevCLAAGITYVPPLLLEVGVEekfmtmvLGIGPVLG--LVSVPLLGSA---- 74
Cdd:COG2807    1 MSTTSSSARRSRRAGRWLLLLAIVLVAL--NLRPAITSVGPLLPEIRAD-------LGLSATQAglLTTLPLLAFGlfap 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  75 -SDHWRGRYGRRRPFIWAL---SLGILLSLFLIPRAGWLAGllcpdprplelALLIlGVGLLdfcgqVCFTPLEALLSDL 150
Cdd:COG2807   72 lAPRLARRFGLERTLLLALlllAAGLLLRSLAPSVALLLAG-----------TALI-GAGIA-----VGNVLLPGLIKRW 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 151 FrdPDHCRQAYSVYAFMISLGGCLGYLLpaidwdTSALAPYLGTQeeclFGLLTLIFLTCVAATLLvaeeAALGPTEPAE 230
Cdd:COG2807  135 F--PDRVGLMTGLYTAAMGLGAALAAGL------TVPLAAALGWR----GALAVWALLALLALLLW----LPLLRRRPAA 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 231 GLSAPSLPShccpcwARLAFRNlgallPRLHQLCcrmprtlrrLFVAeLCSWMALMTFTL---FYTDfvgeglyQGVPRA 307
Cdd:COG2807  199 AAAAPAAAS------LRSLWRS-----PLAWLLT---------LFFG-LQSLLYYAVVAWlppILRD-------AGLSAA 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 308 ELGTearrhydegvrmgSLGLFLqcAISLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGF 387
Cdd:COG2807  251 TAGL-------------LLSLFQ--LAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGL 315

                        410
                 ....*....|....*...
gi 795276398 388 TFSALQILPYTLASLYHR 405
Cdd:COG2807  316 GQGGLFPLALTLIGLRAR 333
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
9-217 3.02e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 56.81  E-value: 3.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   9 RLLRHRKAQLL-LINLLTFGLEVCLAAgitYVPPLLLEV-GVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRR 86
Cdd:COG2223  200 EALRDPRFWLLsLLYFGTFGSFIGFSS---WLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSD----RIGGRR 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  87 PFIWALSLGILLSLFLIpragWLAGllcpdprplELALLILGVGLLDFCGQVCFTPLEALLSDLFRDpdhcRQAYSVYAF 166
Cdd:COG2223  273 VLLIVFALMALGLLLLA----LALG---------SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPT----KNAGAVYGL 335

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 795276398 167 MISLGGCLGYLLPAIdwdTSALAPYLGTQEEClFGLLTLIFLTCVAATLLV 217
Cdd:COG2223  336 VGAAGGLGGFLGPLL---FGALLDATGSYTAA-FLVFAVLALVALVLTLLL 382
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 54-401 5.34e-08

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 56.31  E-value: 5.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  54 TMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRPFIWALS-LGILLSLFLipragWLAGllcpdPRPLELALLILGVGLL 132
Cdd:COG2270   55 GYALAIAGLLVALLAPVLGAIAD----RSGRKKPFLAFFTlLGVLATAAL-----FFVA-----PGGLWLGLLLFVLANI 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 133 DFCGQVCFTplEALLSDLFRDPDHCRqaysVYAFMISLGGCLGYLLPAIDWDTSALAPYLGTQEE------------CLF 200
Cdd:COG2270  121 GFEGSLVFY--NAFLPDIATPEEIGR----VSGLGWALGYLGGVLLLLINLALFLKPEAFGLPDAgeavrisflltaLWW 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 201 GLLTLIFLtcvaatLLVAEEAALGPTEPAEGLsapslpshccpcwaRLAFRNLGALLPRLHQLccrmpRTLRRLFVAELC 280
Cdd:COG2270  195 LLFALPLF------LFLPERPRPGPAPPRGAV--------------RAGFRELRRTLRELRRY-----RDLLRFLLAYFF 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 281 SWMALMTFTLFYTDFVGEGLyqGVPRAELGTearrhydegvrmgsLGLFLQcAISLVFSLVMDRLVQRFGTRAVYLASVA 360
Cdd:COG2270  250 YRDGVQTVIAFAGIYAAGVL--GFSTTELIV--------------FGLLVQ-IVAALGALLFGRLDDRIGPKRVILVSLV 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 795276398 361 AFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLAS 401
Cdd:COG2270  313 IWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLA 353
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
7-218 3.02e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 53.72  E-value: 3.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   7 VSRLLRHRKAQLLLinlLTFGLEVCLAAG-ITYVPPLLLEVGVEEK---FMTMVLGIGPVLGLVSVPLLGsasdhwrGRY 82
Cdd:COG2807  208 LRSLWRSPLAWLLT---LFFGLQSLLYYAvVAWLPPILRDAGLSAAtagLLLSLFQLAGIPGSLLVPLLA-------DRL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  83 GRRRPFIWALSLGILlslfliprAGWLAGLLCPDprplelALLILGVGLLDFCGQVCFTPLEALLSDLFRDPdhcRQAYS 162
Cdd:COG2807  278 GDRRPLLLLLGLLGL--------AGLLGLLLAPG------SLPWLWAVLLGLGQGGLFPLALTLIGLRARTP---AEAAA 340

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795276398 163 VYAFMISlggcLGYLLpaidwdtSALAPYlgtqeecLFGLL-------TLIFLTCVAATLLVA 218
Cdd:COG2807  341 LSGMAQS----VGYLL-------AALGPL-------LVGALhdatgswTAALLLLAALAVLML 385
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 36-401 7.19e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.19  E-value: 7.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  36 ITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRPFIWALsLGILLSLFLIpragwlagLLCP 115
Cdd:cd17325   16 IPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD----RFGRKRLLLLGL-LLLAVSTLLF--------AFAT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 116 DPRPLELALLILGVglldfcGQVCFTPL-EALLSDLFRdPDHCRQAYSVYAFMISLGGCLGYLLpaidwdTSALAPYLGT 194
Cdd:cd17325   83 SYWQLLLARFLQGL------ASAAVWPAaMALIADIAP-PEERGRAMGIFSSAIGLGFLIGPLL------GGLLADALGY 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 195 QEecLFGLLTLIFLTCVAATLLVAEEAAlgPTEPAEGLSAPSLPShccpcwarlafRNLGALLPRLHQLCCRMprtlrrL 274
Cdd:cd17325  150 RA--PFLVCAALALLALVLALLLLPEPR--PPPNKRAVSAARLRS-----------GLRLLLRDRRLLALFLA------I 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 275 FVAELCSWMALMTFTLFYTDFVGEGLYQgvpraelgtearrhydegvrmgsLGLFL--QCAISLVFSLVMDRLVQRFGTR 352
Cdd:cd17325  209 FVLAFAFGALEPFLPLYAAELGGLSPAQ-----------------------IGLLFgaQGLASALSQPPAGKLSDRIGRK 265

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 795276398 353 AVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLAS 401
Cdd:cd17325  266 PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA 314
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 2-181 2.91e-06

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 50.60  E-value: 2.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   2 VQRLWVSRLLRHRKAQLLLINLLTFGLEVCLAAGITYVPPLLLEV-GVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrg 80
Cdd:cd17369  214 VVRAPLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTlGVDRSTVLLAVLIASVVAAITIPLFGWLSD---- 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  81 RYGRRRPFIWALSLGILLSLFLIP----RAGWLAGLlcpdprpleLALLILGVGLLdfcgqVCFTPLEALLSDLFrdPDH 156
Cdd:cd17369  290 RVGRRPVYLAGALLAALFAFPFFWlldtGSTWLIVL---------AAVVVLGVLHG-----MMYGPQAAFLAELF--PTR 353

                        170       180
                 ....*....|....*....|....*.
gi 795276398 157 CRqaYSVYAFMISLGGCL-GYLLPAI 181
Cdd:cd17369  354 VR--YTGASLGYQLGAILgGGFAPLI 377
PHA03247 PHA03247
large tegument protein UL36; Provisional
 606-830 6.45e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 6.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  606 KTENPAEKLAEKKSPQEPTP--------SVIKFVTTPSKKPPVEPVVATISTGPSISPSSEETIQAletlvSPKLPSLEA 677
Cdd:PHA03247 2666 RARRLGRAAQASSPPQRPRRraarptvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQA-----SPALPAAPA 2740

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  678 PTSASNVTTVFAT-----TPPVSSIPPLQEPPRTPS---PPLSSHPDIDTDIDSVASQPmelaenLSLEPKDQDSVLPEK 749
Cdd:PHA03247 2741 PPAVPAGPATPGGparpaRPPTTAGPPAPAPPAAPAagpPRRLTRPAVASLSESRESLP------SPWDPADPPAAVLAP 2814

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  750 DKANNSSRSkkPKGLELAPTLVITSSDPSPLGILSPSLPT------------------ASLTPAFFSQTPIILTPSPLLS 811
Cdd:PHA03247 2815 AAALPPAAS--PAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdvrrrppsrsPAAKPAAPARPPVRRLARPAVS 2892

                         250       260
                  ....*....|....*....|
gi 795276398  812 SihfwSTLS-PVAPLSPARL 830
Cdd:PHA03247 2893 R----STESfALPPDQPERP 2908
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 644-808 3.53e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.60  E-value: 3.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  644 VATISTGPS---ISPSSEETIQALETLVSPKLPSlEAPTSASNVTTVFATTPPVSSIPPLQEPPRTPSPPLSSHPDIDTd 720
Cdd:pfam05109 393 VSGLGTAPKtliITRTATNATTTTHKVIFSKAPE-STTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVST- 470

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  721 IDSVASQPMELAENLSL-----EPKDQDSVLPEKDKANNSSRSKKPKGLELAPTLVITSSDP---SP-LGILSPSLPTAS 791
Cdd:pfam05109 471 ADVTSPTPAGTTSGASPvtpspSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPnatSPtLGKTSPTSAVTT 550

                         170
                  ....*....|....*..
gi 795276398  792 LTPAFFSQTPIILTPSP 808
Cdd:pfam05109 551 PTPNATSPTPAVTTPTP 567
PHA03247 PHA03247
large tegument protein UL36; Provisional
 620-865 3.71e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 3.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  620 PQEPTPSVIKFVTTPSKKP-PVEPVVATISTGPSISPSSeetiqaletlVSPKLPSleAPTSAsnvttvFATTPPVSSIP 698
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPAPrPSEPAVTSRARRPDAPPQS----------ARPRAPV--DDRGD------PRGPAPPSPLP 2618

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  699 PLQEPPRTPSPPLSSHPDIDTDIDSVASQPMELAENLS----LEPKDQDSVLPEKDKANNSSRSKKPKGLELAPTLVITS 774
Cdd:PHA03247 2619 PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPapgrVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSL 2698

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  775 SDPSPlgilsPSLPTASLTPAFFSQTPIILTPSPLLSSihfwSTLSPVAPLSPARLQGANTlfqfPSVLNSHG-PFTLSG 853
Cdd:PHA03247 2699 ADPPP-----PPPTPEPAPHALVSATPLPPGPAAARQA----SPALPAAPAPPAVPAGPAT----PGGPARPArPPTTAG 2765

                         250
                  ....*....|...
gi 795276398  854 LDGPSTP-GPFSP 865
Cdd:PHA03247 2766 PPAPAPPaAPAAG 2778
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 36-395 4.60e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.42  E-value: 4.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  36 ITYVPPLLLEVGVEEK---FMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRPFIWALsLGILLSLFLIpragwlaGL 112
Cdd:cd17330   16 FPVLPFYVREFNKLGAsgyYVGLLQSSYSLGQFLASPLWGRLSD----RYGRKPVLLLSL-AGSAVSYVLL-------GL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 113 LCPdprpleLALLILGVGLLDFCGqVCFTPLEALLSDLFRDPDHcRQAYSVYAFMISLGGCLGyllpaidwdtSALAPYL 192
Cdd:cd17330   84 SRN------LWLLFLARFLDGLTG-GNVSVAQAYIADITDEEER-AKAFGIISAAFGLGFILG----------PALGGFL 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 193 GTqeecLFGlltlIFLTCVAATLLvaeeaalgptepaeglsapslpshccpcwarlafrNLGALLprlhqLCCRMPRTLR 272
Cdd:cd17330  146 ST----PYG----YALPFLVAAAL-----------------------------------ALLNLV-----LVLFFLPPLR 177

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 273 RLFVAELCSWMAlmtFTLFYTDFvgeGLYqgvpraelgTEARRHYDEGVrMGSLGLFLQCAISLVFSLVMDRLVQRFGTR 352
Cdd:cd17330  178 RLLLVYFLIALA---FAGLESVF---SLF---------LKDRFGFSPSQ-IGLLLALVGIAGILAQLLLIPRLAKRLGER 241

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 795276398 353 AVYLASVAAFPVAAGATCLSHSVAVVTASAAL----TGFTFSALQIL 395
Cdd:cd17330  242 KLLRLGLLLAIIGLLLLPFASSVPLLVLAAAIlafgTGIVFPALSAL 288
MFS_1 pfam07690
Major Facilitator Superfamily;
274-408 7.29e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.87  E-value: 7.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  274 LFVAELCSWMALMTFTLFYTDFVGEGLyqGVPRAELGtearrhydegvrmgsLGLFLQCAISLVFSLVMDRLVQRFGTRA 353
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDL--GISPTEIG---------------LLLTLFSLGYALAQPLAGRLSDRFGRRR 63

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 795276398  354 VYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLASLYHRERQ 408
Cdd:pfam07690  64 VLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEE 118
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 18-393 8.08e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 45.66  E-value: 8.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  18 LLLINLLTFGlevCLAAGITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRPFIWALSLGIL 97
Cdd:cd17489    1 ILLANFFFFL---SFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLD----RFGRKRLLLIGLLIFAL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  98 LSLFLIPrAGWLAGLLcpdprpleLALLILGVglldfcGQVCFTPLEALLSDLFRDPDHCRQAYSVYAFMISLGGCLGYL 177
Cdd:cd17489   74 ATLLYLL-ATSVALLL--------VLRLIHGI------GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPA 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 178 LPaidwdtSALAPYLGtqeeclFGLLTLIFLTCVAATLLVaeeAALGPTEPAEGLSAPSLPShccpcWARLAFRNLGALL 257
Cdd:cd17489  139 LG------LFLYQHLG------FAVLFIVAAVLALLALLL---VFLVKDPPPVAAEEAEAGT-----RAFRRLVEKKVLP 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 258 PRLHQLCCRMPrtlrrlfvaelcsWMALMTFTLFYTDfvgeglyqgvpraelgtearrhyDEGVRMGSLGLFLQCAISLV 337
Cdd:cd17489  199 PALILFLASIA-------------YGAISTFLPLYAA-----------------------ERGISNAGLFFTVYAIALLL 242

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 795276398 338 FSLVMDRLVQRFGTRAVylASVAAFPVAAGATCLS--HSVAVVTASAALTGFTFSALQ 393
Cdd:cd17489  243 SRPFSGKLSDRKGPKTV--IIPGLLLLALGLLLLSfaGSPWMLLLAAVLYGLGFGLLF 298
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 57-179 8.73e-05

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 45.95  E-value: 8.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  57 LGI--GPVLGLVSVPLL--------GSASDHWRGRYGRRRPFIWalsLGILLSLFLIPRAGWLAGLLCPDPRPLELALLI 126
Cdd:cd06176   31 LGLpaTLVGLLIALHYLvaplrvwiGHRSDTHPLRGYRRTPYIW---LGMLLLALGLALAPFAALLLAGAAFWLGLALAV 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 795276398 127 LGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYSVYAFMIsLG-----GCLGYLLP 179
Cdd:cd06176  108 LAFLLYGIGVGAAGTAFLALLADLTPEERRPRAVTVVWTMLI-LGiivtaIVFGRLLD 164
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 9-113 2.16e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.47  E-value: 2.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   9 RLLRHRKAQLLLINLLTFGLEVCLAAGITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRPF 88
Cdd:cd17478  188 STLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSD----RFGRRRVI 263

                         90       100
                 ....*....|....*....|....*
gi 795276398  89 IWALSLGILLSLFLIPRAGWLAGLL 113
Cdd:cd17478  264 IASLLLAAPFLLLFLLTPGIWSYIL 288
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 9-217 2.25e-04

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 44.59  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398   9 RLLRHRKAQLLLINLLTFGLEVCLAAGITYVPPLL-LEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRP 87
Cdd:cd17367  216 RELRRHPRELLLVVGLTAGGTLAFYTWTTYLQKFLvNTAGFSKGDATWITTAALLVFMLLQPLGGRLSD----RIGRRPL 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  88 FIWALSLGILLSLFLIPRAGwlagllcPDPRPLELALLILgVGLldfCGQVCFTPLEALLS-DLFrdPDHCRqaysvyaf 166
Cdd:cd17367  292 LLFFGIGGTLATVPLLSALD-------HTDSPYTAFALVL-VGL---VFLSGYTSINAVVKaELF--PTHVR-------- 350

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 795276398 167 miSLGGCLGYLLpaidwdTSAL----APYLGT------QEECLFGLLTliflTCVAATLLV 217
Cdd:cd17367  351 --ALGVGLPYAL------AVAIfggtAPYVALwlksigHEWVFFWYVA----GLIAISLVV 399
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
323-407 2.40e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.46  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 323 MGSLGLFLQCAISLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLASL 402
Cdd:COG0738   44 QAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA 123


                 ....*
gi 795276398 403 YHRER 407
Cdd:COG0738  124 LGPET 128
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 56-389 2.83e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.14  E-value: 2.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  56 VLGIGPVLGLVSVPLLGSASDhwrgRYGRRRpfiwALSLGILLSLFLIpragwlaGLLCPDPRPLELALLILGVGlldFC 135
Cdd:cd17329   40 VLALSAVAGIVASLIGGRLAD----RFGRKP----VMLAGLLLRALGF-------ALLGFAHSPWLFAIALVLTG---FG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 136 GQVCFTPLEALLSDLFRdPDHCRQAYSVYAFMISLGGCLGYLLpaidwdtSALAPYLGTQEECLFGLLTLIFLTCVAATL 215
Cdd:cd17329  102 GGLFEPASEAMIADVTT-PENRTRAFSLLYWAINLGVAIGPLL-------GGLLLLYSFRLLFLAAAVLFLLAALVLLFL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 216 LVAEEAALGPTEPAEGLSAPslpshccpcwaRLAFRNlgallprlhqlccrmpRTLRRLFVAELCSWMALMTFTLFYTDF 295
Cdd:cd17329  174 LPETRPKRRAAEKTEILRGY-----------KIVLRD----------------RAFLLFLLASFLISLIYFQLESTLPVY 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 296 VGEGLYqgvpraelgtearrhydEGVRMGSLGLFLQCAISLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLSHSV 375
Cdd:cd17329  227 VVEILG-----------------LGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTL 289

                        330
                 ....*....|....
gi 795276398 376 AVVTASAALtgFTF 389
Cdd:cd17329  290 AVLILAMIV--LTL 301
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 53-399 4.51e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 43.37  E-value: 4.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  53 MTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRPFIWA--LSLGILLSLFLIPRAGWLagllcpdprplELALLILGVG 130
Cdd:cd06173   36 VGLVLAAFFLPFLLFSPFAGVLAD----RFDRRRLLILAdlLRALLAAVLALLALLGSL-----------SLWLLLVLAF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 131 LLDFCGQVcFTP-LEALLSDLFrDPDHCRQAYSVYAFMISLGGCLGYllpaidwdtsALAPYLGTqeecLFGLLTLIFLT 209
Cdd:cd06173  101 LLGIASAF-FGPaRQALLPELV-PKEQLVRANALNSLATQLARIIGP----------ALGGLLVA----LLGPGGAFAIN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 210 CVAATLLVAEEAALGPTEPAEGLSAPSlpshccpcWARLAFRNLGALLprlhqlccRMPRTLRRLFVAELCSWMALMTFT 289
Cdd:cd06173  165 ALSFLLSALLLLFIRRPPPAAPGESSS--------LLLRDLREGLRYL--------RRSPLLRLLLLALALFALLGGALT 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 290 LFYTDFVGEGLyqGVPRAELGT-EArrhydegvrMGSLGlflqcaiSLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGA 368
Cdd:cd06173  229 VLLPLLAKEVL--GGGAAGYGLlLA---------AFGVG-------ALLGALLLGRLSKRRRRGRLLLIGALLLGLALLV 290

                        330       340       350
                 ....*....|....*....|....*....|.
gi 795276398 369 TCLSHSVAVVTASAALTGFTFSALQILPYTL 399
Cdd:cd06173  291 LGLSPSLWLLLAALFLLGLAGGLFNVPLNTL 321
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 14-218 5.44e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.97  E-value: 5.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  14 RKAQLLLInLLTFGLEVCLAAGITYVPPLLLEV-GVEEKFMTMVLGIGPVLGLVSVPLLGSASDHWrgryGRRRPFIWAL 92
Cdd:cd17316  176 RRRTLLLI-LLWFFISFGYYGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRI----GRKKTLVIGL 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  93 slgILLSLFLIPRAGWLAGllcpdprplELALLILGVGLLDFCGQVCFTPLEALLSDLFrdPDHCRqaYSVYAFMISLGG 172
Cdd:cd17316  251 ---ILSGILALPLFYLLSG---------SPTLLLLLLFILSFFVGGVWGALYAYLAELF--PTEVR--ATGVGLSYNLGR 314

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 795276398 173 CLGYLLPAIdwdTSALAPYLGTqeeclFGLLTLIFLTCVAATLLVA 218
Cdd:cd17316  315 LGGGGAPPL---IALLLASTGG-----TGVPALILALLAIVALIVA 352
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 53-291 9.23e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 42.11  E-value: 9.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  53 MTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRPFIWALSLGILLSLflipragwLAGLLcPDPRPLELALLILGVGll 132
Cdd:COG0477   51 LGWIVSAYLLGRAIGLLLFGRLGD----RYGRKRVLLIGLLLFGLASL--------LCGLA-PSPELLIAARALQGIG-- 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 133 dfcGQVCFTPLEALLSDLFRDPDHCRqAYSVYAFMISLGGCLGYLLpaidwdTSALAPYLGTQeeCLFGLLTLIFLTCVA 212
Cdd:COG0477  116 ---AGGLMPGALALIAELFPARERGR-ALGLWGAAIGLGLALGPLL------GGLLVAALGWR--WIFLINAPLGLLALV 183

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 795276398 213 ATLLVAEEAALGPTEPAEGLSAPSLPSHCCPCWARLAFRNLGALLPRLHQLCCRMPRTLRRLFVAELCSWMALMTFTLF 291
Cdd:COG0477  184 LRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAAL 262
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
39-401 1.34e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.78  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  39 VPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRPFIWALslgILLSLFLIpragwLAGLLcpdPR 118
Cdd:COG2271   33 APPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD----RFGRRRVLAIGL---LLWGLATL-----LFGFA---TS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 119 PLELALLILGVGLldFCGqVCFTPLEALLSDLFrdPDHCR-QAYSVYAFMISLGGCLGYLLpaidwdTSALAPYLGTQee 197
Cdd:COG2271   98 FWQLLLLRFLLGL--GEA-GFFPAALKLIAEWF--PPKERgRALGIFNAGGPLGGALAPPL------LGWLLAAFGWR-- 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 198 clfglltLIFLTCVAATLLVaeeaalgptepaeglsapslpshccpcwarlafrnlgALLprlhqlccrmprTLRRLFVA 277
Cdd:COG2271  165 -------AAFLILGLPGLLL-------------------------------------ALL------------RFWLLALA 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 278 ELCSWMALMTFTLFYTDFVGEGLyqGVPRAELGTearrhydegvrMGSLGLFLQCAISLVFSLVMDRLVQRfgTRAVYLA 357
Cdd:COG2271  189 YFLVYFALYGFLTWLPTYLVEVR--GLSLAQAGL-----------LLSLPFLAGIVGSLLGGWLSDRLGRR--RKLVLAI 253

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 795276398 358 SVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTLAS 401
Cdd:COG2271  254 GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAA 297
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 320-392 1.38e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 41.86  E-value: 1.38e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 795276398 320 GVRMGSLGLFLQC--AISLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSAL 392
Cdd:cd17393   30 GLSDAALGLLLLAlgVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGAL 104
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 553-711 1.59e-03

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 41.69  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  553 SGSSKDVENGGKEKPPQPSAKTSSrndyihsglySSFTLNSLNSSnvklfkliKTENPAEKLAEKKSPQ-EPTPSVIKFV 631
Cdd:pfam13254 197 PNSFKEVTPVGLMRSPAPGGHSKS----------PSVSGISADSS--------PTKEEPSEEADTLSTDkEQSPAPTSAS 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  632 TTPSKKPPVEPVVATiSTGPSISPSSEETIQALETLVSPKLPSLEAPTSASNVTTVFATTPPVSSIP--PLQEPPRTPSP 709
Cdd:pfam13254 259 EPPPKTKELPKDSEE-PAAPSKSAEASTEKKEPDTESSPETSSEKSAPSLLSPVSKASIDKPLSSPDrdPLSPKPKPQSP 337


                  ..
gi 795276398  710 PL 711
Cdd:pfam13254 338 PK 339
LAT pfam15234
Linker for activation of T-cells;
671-761 1.88e-03

Linker for activation of T-cells;


Pssm-ID: 464576  Cd Length: 233  Bit Score: 41.01  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  671 KLPSLEAPTSASNvttvfaTTPPVSSIPPLQEP-----PRTPSPPLSSH--PDIDTDIDSVASQPMELAENLSLEPKDQD 743
Cdd:pfam15234  53 KRPPTLAPWPPAT------SYPPVTSYPPLSQPdllpiPRSPQPPGGSHrmPSSRQDSDGANSVASYENEEPACEDADED 126

                          90       100       110
                  ....*....|....*....|....*....|
gi 795276398  744 S------------VLPEKDKANNSSRSKKP 761
Cdd:pfam15234 127 EdeedyhnegylvVLPDSTPATSTAVPSAP 156
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
335-407 2.37e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.11  E-value: 2.37e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 795276398 335 SLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFSALQILPYTL-ASLYHRER 407
Cdd:COG2814   58 AALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALiADLVPPER 131
Not5 COG5665
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
620-804 4.84e-03

CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];


Pssm-ID: 444384 [Multi-domain]  Cd Length: 874  Bit Score: 40.80  E-value: 4.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 620 PQEPTPSVIKFVTTPSKKPPVEPVVATISTGPSISPSS---EETIQALETLVSPK--LPSLEAPTSASNV----TTVFAT 690
Cdd:COG5665  334 ASVPTTEETTAFTTPSSVPSTPAEKDTPATDLATPVSPtppETSVDKKVSPDSATssTKSEKEGGTASSPmppnIAIGAK 413

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 691 TPPVSSIPPLQEPPRTPSPPLSshPDIDTDIDSVASQPMELAENLSLEPKDQdsvLPEKDKANNSSRSKKPKGLELAPTL 770
Cdd:COG5665  414 DDVDATDPSQEAKEYTKNAPMT--PEADSAPESSVRTEASPSAGSDLEPENT---TLRDPAPNAIPPPEDPSTIGRLSSG 488

                        170       180       190
                 ....*....|....*....|....*....|....
gi 795276398 771 VITSSDPSPLGILSPSLPTASLTPAFFSQTPIIL 804
Cdd:COG5665  489 DKLANETGPPVIRRDSTPSSTADQSIVGVLAFGL 522
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
 592-793 5.45e-03

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 40.36  E-value: 5.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 592 NSLNSSNVKLFKLIKTENPAEKLAEKKSPQEPTPS--VIKFVTTPSKKPPVEPVVAT--ISTGPSISPSSEETIQALETL 667
Cdd:PRK05901   1 MTTASTKAELAAEEEAKKKLKKLAAKSKSKGFITKeeIKEALESKKKTPEQIDQVLIflSGMVKDTDDATESDIPKKKTK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 668 VSPKLPSLEAPTSASNVTTVFATTPPVSSIPPLQEPPRTPSPPLSSHPDIDTDID-SVASQPMELAENLSLEPKDQDSVL 746
Cdd:PRK05901  81 TAAKAAAAKAPAKKKLKDELDSSKKAEKKNALDKDDDLNYVKDIDVLNQADDDDDdDDDDDLDDDDIDDDDDDEDDDEDD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 795276398 747 PEKDKANNSSRSKKPKGLELAPTLVITSSDPSPLGILSPSLPTASLT 793
Cdd:PRK05901 161 DDDDVDDEDEEKKEAKELEKLSDDDDFVWDEDDSEALRQARKDAKLT 207
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 271-390 8.18e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.52  E-value: 8.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398 271 LRRLFVAELCSWMALMTFTLFYTDFVGEglYQGVPRAELGtearrhydegvrmgsLGLFLQCAISLVFSLVMDRLVQRFG 350
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQ--QLGLSASIVG---------------LVLALSAVAGIVASLIGGRLADRFG 63

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 795276398 351 TRAVYLASVAAFPVAAGATCLSHSVAVVTASAALTGFTFS 390
Cdd:cd17329   64 RKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGG 103
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 14-218 9.32e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.08  E-value: 9.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  14 RKAQLLLINLLTFGLEVclAAGITYVPPLLLEVGVEEKFMTMVLGIGPVLGLVSVPLLGSASDhwrgRYGRRRPFIWALS 93
Cdd:cd17477  188 RIAPLALLGAFVAGFLE--GAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLAD----RFDRRRVLLGCAL 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795276398  94 LGILLSLFLipragWLAGllcpdprPLELALLILGVgLLDFCGQVCFTPLEALLSDLFrDPDHCRQAYSVYAFMISLGGC 173
Cdd:cd17477  262 LGALAALLL-----PLVP-------GLPLALLVLLF-LWGGAAGPLYTLALALAGDRL-PGDELVAANAALLLLYGLGSV 327

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 795276398 174 LGYLLpaidwdTSALAPYLGTQeeclfGLltLIFLTCVAATLLVA 218
Cdd:cd17477  328 IGPLL------AGALMDAFGPH-----GL--FLFLAAVALLFLLF 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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