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Conserved domains on  [gi|780046924|ref|XP_011668984|]
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dorsal-ventral patterning tolloid-like protein 1 [Strongylocentrotus purpuratus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 123-225 4.43e-33

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


:

Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 122.11  E-value: 4.43e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780046924   123 GVFYSPGFPDYYGSSLKCTYIVTSSKaDNTILLRFPSFDVEESINCVYDYVEIRDGDSETSELLNRYCGASLPENTISST 202
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPP-GYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSS 79

                           90       100
                   ....*....|....*....|...
gi 780046924   203 GPAMFVRFRSDSSNVFKGFYAEY 225
Cdd:smart00042  80 SNSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 19-96 1.21e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.39  E-value: 1.21e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 780046924  19 RRVRIFFSSFTLENPNDlniCNFDYLAIYDGGSDVDPSLGMFCGPQNPPATITTGNELYVVFHTDSSIQKTGFRAEIT 96
Cdd:cd00041   38 YRIRLTFEDFDLESSPN---CSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 377-412 1.34e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.34e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 780046924 377 CEDGDWHCDNNRCIAKNLICDGYDHCRDNSDEErGC 412
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE-NC 35
 
Name Accession Description Interval E-value
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 123-225 4.43e-33

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 122.11  E-value: 4.43e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780046924   123 GVFYSPGFPDYYGSSLKCTYIVTSSKaDNTILLRFPSFDVEESINCVYDYVEIRDGDSETSELLNRYCGASLPENTISST 202
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPP-GYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSS 79

                           90       100
                   ....*....|....*....|...
gi 780046924   203 GPAMFVRFRSDSSNVFKGFYAEY 225
Cdd:smart00042  80 SNSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 114-225 1.92e-32

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 120.59  E-value: 1.92e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780046924 114 CYYTYT-EEHGVFYSPGFPDYYGSSLKCTYIVTSSKaDNTILLRFPSFDVEESINCVYDYVEIRDGDSETSELLNRYCGA 192
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPP-GYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 780046924 193 SLPEnTISSTGPAMFVRFRSDSSNVFKGFYAEY 225
Cdd:cd00041   80 TLPP-PIISSGNSLTVRFRSDSSVTGRGFKATY 111
CUB pfam00431
CUB domain;
114-225 6.80e-30

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 113.54  E-value: 6.80e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780046924  114 CYYTYTEEHGVFYSPGFPDYYGSSLKCTYIVTSSKAdNTILLRFPSFDVEESINCVYDYVEIRDGDSETSELLNRYCGAS 193
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPG-FRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSG 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 780046924  194 LPEnTISSTGPAMFVRFRSDSSNVFKGFYAEY 225
Cdd:pfam00431  80 IPE-DIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 19-96 1.21e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.39  E-value: 1.21e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 780046924  19 RRVRIFFSSFTLENPNDlniCNFDYLAIYDGGSDVDPSLGMFCGPQNPPATITTGNELYVVFHTDSSIQKTGFRAEIT 96
Cdd:cd00041   38 YRIRLTFEDFDLESSPN---CSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 19-93 1.16e-18

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 81.28  E-value: 1.16e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 780046924    19 RRVRIFFSSFTLENPNDlniCNFDYLAIYDGGSDVDPSLGMFCGPQNPPATITT-GNELYVVFHTDSSIQKTGFRA 93
Cdd:smart00042  28 YRIELQFTDFDLESSDN---CEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSsSNSLTLTFVSDSSVQKRGFSA 100
CUB pfam00431
CUB domain;
19-93 5.54e-15

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 71.17  E-value: 5.54e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 780046924   19 RRVRIFFSSFTLEnpnDLNICNFDYLAIYDGGSDVDPSLGMFCGPQNPPATITTGNELYVVFHTDSSIQKTGFRA 93
Cdd:pfam00431  37 FRVKLTFQDFELE---DHDECGYDYVEIRDGPSASSPLLGRFCGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKA 108
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 377-412 1.34e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.34e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 780046924 377 CEDGDWHCDNNRCIAKNLICDGYDHCRDNSDEErGC 412
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE-NC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 377-408 1.43e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.43e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 780046924   377 CEDGDWHCDNNRCIAKNLICDGYDHCRDNSDE 408
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
377-410 3.56e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 3.56e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 780046924  377 CEDGDWHCDNNRCIAKNLICDGYDHCRDNSDEER 410
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
 
Name Accession Description Interval E-value
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 123-225 4.43e-33

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 122.11  E-value: 4.43e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780046924   123 GVFYSPGFPDYYGSSLKCTYIVTSSKaDNTILLRFPSFDVEESINCVYDYVEIRDGDSETSELLNRYCGASLPENTISST 202
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPP-GYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSS 79

                           90       100
                   ....*....|....*....|...
gi 780046924   203 GPAMFVRFRSDSSNVFKGFYAEY 225
Cdd:smart00042  80 SNSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 114-225 1.92e-32

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 120.59  E-value: 1.92e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780046924 114 CYYTYT-EEHGVFYSPGFPDYYGSSLKCTYIVTSSKaDNTILLRFPSFDVEESINCVYDYVEIRDGDSETSELLNRYCGA 192
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPP-GYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 780046924 193 SLPEnTISSTGPAMFVRFRSDSSNVFKGFYAEY 225
Cdd:cd00041   80 TLPP-PIISSGNSLTVRFRSDSSVTGRGFKATY 111
CUB pfam00431
CUB domain;
114-225 6.80e-30

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 113.54  E-value: 6.80e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780046924  114 CYYTYTEEHGVFYSPGFPDYYGSSLKCTYIVTSSKAdNTILLRFPSFDVEESINCVYDYVEIRDGDSETSELLNRYCGAS 193
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPG-FRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSG 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 780046924  194 LPEnTISSTGPAMFVRFRSDSSNVFKGFYAEY 225
Cdd:pfam00431  80 IPE-DIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 19-96 1.21e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.39  E-value: 1.21e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 780046924  19 RRVRIFFSSFTLENPNDlniCNFDYLAIYDGGSDVDPSLGMFCGPQNPPATITTGNELYVVFHTDSSIQKTGFRAEIT 96
Cdd:cd00041   38 YRIRLTFEDFDLESSPN---CSYDYLEIYDGPSTSSPLLGRFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 19-93 1.16e-18

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 81.28  E-value: 1.16e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 780046924    19 RRVRIFFSSFTLENPNDlniCNFDYLAIYDGGSDVDPSLGMFCGPQNPPATITT-GNELYVVFHTDSSIQKTGFRA 93
Cdd:smart00042  28 YRIELQFTDFDLESSDN---CEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSsSNSLTLTFVSDSSVQKRGFSA 100
CUB pfam00431
CUB domain;
19-93 5.54e-15

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 71.17  E-value: 5.54e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 780046924   19 RRVRIFFSSFTLEnpnDLNICNFDYLAIYDGGSDVDPSLGMFCGPQNPPATITTGNELYVVFHTDSSIQKTGFRA 93
Cdd:pfam00431  37 FRVKLTFQDFELE---DHDECGYDYVEIRDGPSASSPLLGRFCGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKA 108
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 377-412 1.34e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.34e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 780046924 377 CEDGDWHCDNNRCIAKNLICDGYDHCRDNSDEErGC 412
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE-NC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 377-408 1.43e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.43e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 780046924   377 CEDGDWHCDNNRCIAKNLICDGYDHCRDNSDE 408
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
377-410 3.56e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 3.56e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 780046924  377 CEDGDWHCDNNRCIAKNLICDGYDHCRDNSDEER 410
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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