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Conserved domains on  [gi|767988506|ref|XP_011544130|]
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interleukin-4 receptor subunit alpha isoform X3 [Homo sapiens]

Protein Classification

IL4Ra_N and FN3 domain-containing protein( domain architecture ID 10283511)

IL4Ra_N and FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL4Ra_N super family cl07754
Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall ...
 1-32 3.35e-14

Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.


The actual alignment was detected with superfamily member pfam09238:

Pssm-ID: 462720  Cd Length: 94  Bit Score: 68.55  E-value: 3.35e-14
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767988506    1 MDDVVSADNYTLDLWAGQQLLWKGSFKPSEHV 32
Cdd:pfam09238  63 MDDFVSADTYSLELWAGGQLLWQGSFKPSEHV 94
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 34-130 1.69e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988506  34 PRAPGNLTVHTNVSDTLLLTWSnpyPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIaaSTLKSGISYRARVR 113
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWT---PPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTL--TGLKPGTEYEFRVR 75

                         90
                 ....*....|....*..
gi 767988506 114 AWaqcYNTTWSEWSPST 130
Cdd:cd00063   76 AV---NGGGESPPSESV 89
 
Name Accession Description Interval E-value
IL4Ra_N pfam09238
Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall ...
 1-32 3.35e-14

Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.


Pssm-ID: 462720  Cd Length: 94  Bit Score: 68.55  E-value: 3.35e-14
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767988506    1 MDDVVSADNYTLDLWAGQQLLWKGSFKPSEHV 32
Cdd:pfam09238  63 MDDFVSADTYSLELWAGGQLLWQGSFKPSEHV 94
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 34-130 1.69e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988506  34 PRAPGNLTVHTNVSDTLLLTWSnpyPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIaaSTLKSGISYRARVR 113
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWT---PPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTL--TGLKPGTEYEFRVR 75

                         90
                 ....*....|....*..
gi 767988506 114 AWaqcYNTTWSEWSPST 130
Cdd:cd00063   76 AV---NGGGESPPSESV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 34-114 1.01e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988506    34 PRAPGNLTVHTNVSDTLLLTWSNPYPPdnylyNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVR 113
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDD-----GITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                   .
gi 767988506   114 A 114
Cdd:smart00060  76 A 76
fn3 pfam00041
Fibronectin type III domain;
36-127 1.83e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988506   36 APGNLTVHTNVSDTLLLTWSNPYPPDNYLynhLTYAVNIWSENDPADFRIYNVTYLEPSLRIaaSTLKSGISYRARVRAw 115
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPI---TGYEVEYRPKNSGEPWNEITVPGTTTSVTL--TGLKPGTEYEVRVQA- 75

                          90
                  ....*....|..
gi 767988506  116 aqCYNTTWSEWS 127
Cdd:pfam00041  76 --VNGGGEGPPS 85
 
Name Accession Description Interval E-value
IL4Ra_N pfam09238
Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall ...
 1-32 3.35e-14

Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.


Pssm-ID: 462720  Cd Length: 94  Bit Score: 68.55  E-value: 3.35e-14
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767988506    1 MDDVVSADNYTLDLWAGQQLLWKGSFKPSEHV 32
Cdd:pfam09238  63 MDDFVSADTYSLELWAGGQLLWQGSFKPSEHV 94
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 34-130 1.69e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988506  34 PRAPGNLTVHTNVSDTLLLTWSnpyPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIaaSTLKSGISYRARVR 113
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWT---PPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTL--TGLKPGTEYEFRVR 75

                         90
                 ....*....|....*..
gi 767988506 114 AWaqcYNTTWSEWSPST 130
Cdd:cd00063   76 AV---NGGGESPPSESV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 34-114 1.01e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988506    34 PRAPGNLTVHTNVSDTLLLTWSNPYPPdnylyNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVR 113
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDD-----GITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                   .
gi 767988506   114 A 114
Cdd:smart00060  76 A 76
fn3 pfam00041
Fibronectin type III domain;
36-127 1.83e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988506   36 APGNLTVHTNVSDTLLLTWSNPYPPDNYLynhLTYAVNIWSENDPADFRIYNVTYLEPSLRIaaSTLKSGISYRARVRAw 115
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPI---TGYEVEYRPKNSGEPWNEITVPGTTTSVTL--TGLKPGTEYEVRVQA- 75

                          90
                  ....*....|..
gi 767988506  116 aqCYNTTWSEWS 127
Cdd:pfam00041  76 --VNGGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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