Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767968175   308 CEEDNGGCSHLCLLSPSepFYTCACPTGVQLQDNGRTC 345
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968175    504 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKR 546
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767968175 1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767968175 1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1341
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767968175   915 CMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNC 950
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968175    196 KIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFR 238
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968175    762 QVLVWRDLDNPRSLALDPTKGYIYWTEWgGKPRIVRAFMDGTNC 805
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968175  694 SNNHIYWTDVSLKTISR-----AFMNGSSVEHVVEFGLDYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQFRQVLV--- 765
Cdd:cd05819    17 SSGNIYVADTGNNRIQVfdpdgNFITSFGSFGSGDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGgsg 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968175  766 --WRDLDNPRSLALDPtKGYIYWTEWGGKpRIVRaFMDGTNCMTLVDKVGRAN-------DLTIDyADQRLYWTDLDTNM 836
Cdd:cd05819    96 dgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK-FDPDGEFLTTFGSGGSGPgqfngptGVAVD-SDGNIYVADTGNHR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767968175  837 IE----SSNML---GQERVVIAdDLPHPFGLT-QYSDYIYWTDWNLHSIERADKTSGRN 887
Cdd:cd05819   172 IQvfdpDGNFLttfGSTGTGPG-QFNYPTGIAvDSDGNIYVADSGNNRVQVFDPDGAGF 229

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968175   1113 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR 1155
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767968175    547 RTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV 580
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968175   1069 VVLRGDRDKPRAIVVNAERGYLYFTNMqdRAAKIERAALDGTER 1112
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767968175   308 CEEDNGGCSHLCLLSPSepFYTCACPTGVQLQDNGRTC 345
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968175    504 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKR 546
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767968175 1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968175    460 KILVSEDLDEPRAIALHPVMGLMYWTDWGeNPKIECANLDGQER 503
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968175    719 EHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 761
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968175    152 KVLFWQDLDQPRAIALDPAHGYMYWTDWGeTPRIERAGMDGSTR 195
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968175    111 VVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 151
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 767968175   1267 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDE 1301
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|..
gi 767968175   1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1376
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767968175  1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767968175   437 RNLYWTDTGTD-RIEVTRLNGTSRKILVSEDLDEPRAIALHP 477
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968175    762 QVLVWRDLDNPRSLALDPTKGYIYWTEWgGKPRIVRAFMDGTNC 805
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43

DNA-binding beta-propeller fold protein YncE [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968175   34 AAQYFPASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGA----VYWTDVSEEAIkqTYLNQTGAAVQ 109
Cdd:COG3391    26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRV--SVIDLATGKVV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968175  110 NVVISGlVSPDGLACDWVGKKLYWTDSETNRIEVanLNGTSRKVL-FWQDLDQPRAIALDPAHGYMYWTDWGeTPRIER- 187
Cdd:COG3391   104 ATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVi 179

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 767968175  188 -AGMDGSTRKII--VDSDIYwPNGLTIDLEEQKLYWADA 223
Cdd:COG3391   180 vSVIDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANR 217

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968175  383 HAIAIDYDpleGYVYWTDDEVRAIRR-----AYLDGSGAQTLVNTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 457
Cdd:cd05819    58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968175  458 SRKIL-----VSEDLDEPRAIALHPVmGLMYWTDWGENpKIECANLDGQERRVL-----VNASLGWPNGLALDlQEGKLY 527
Cdd:cd05819   134 FLTTFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNH-RIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVD-SDGNIY 210

                         170
                  ....*....|....*..
gi 767968175  528 WGDAKTDKIEVINVDGT 544
Cdd:cd05819   211 VADSGNNRVQVFDPDGA 227

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968175    375 VLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSG 415
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968175   46 FANRRDVRLvdAGGVKLESTIVVSGLEDAA--AVDFQfskGAVYWTD-VSEEAIKQtylnQTGAAVQNVV-ISGLVSPDG 121
Cdd:cd14952    70 FGNNRVLKL--AAGSTTQTVLPFTGLNDPTgvAVDAA---GNVYVADtGNNRVLKL----AAGSNTQTVLpFTGLSNPDG 140

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767968175  122 LACDWVGKkLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAhGYMYWTD 178
Cdd:cd14952   141 VAVDGAGN-VYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDTA-GNVYVTD 195

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 767968175    808 LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 847
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767968175   394 GYVYWTDDEVRA-IRRAYLDGSGAQTLVNTEINDPDGIAVDW 434
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767968175  721 VVEF-GLDYPEGMAVDWMGkNLYWADTGTNRieVARLD-GQFRQ-VLVWRDLDNPRSLALDPTkGYIY 785
Cdd:cd14952     3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVY 66

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767968175    547 RTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV 580
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968175    979 ILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQ 1018
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwGLDVIEVANLDGTN 42

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767968175   782 GYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDY 822
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 767968175    239 QKVVEGSLTHP--FALTLSGDTLYWTDWQTRSIHACN 273
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767968175   308 CEEDNGGCSHLCLLSPSepFYTCACPTGVQLQDNGRTC 345
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968175    504 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKR 546
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767968175 1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968175    460 KILVSEDLDEPRAIALHPVMGLMYWTDWGeNPKIECANLDGQER 503
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968175    719 EHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 761
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968175    152 KVLFWQDLDQPRAIALDPAHGYMYWTDWGeTPRIERAGMDGSTR 195
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968175    111 VVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 151
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 767968175   1267 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDE 1301
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33