Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1547-1904
0e+00
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.
:
Pssm-ID: 465298 [Multi-domain] Cd Length: 355 Bit Score: 650.53 E-value: 0e+00
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1124-1380
2.66e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 224.45 E-value: 2.66e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
26-318
9.75e-65
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 220.22 E-value: 9.75e-65
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
805-1042
5.81e-50
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 177.46 E-value: 5.81e-50
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
467-698
1.59e-48
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 173.61 E-value: 1.59e-48
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1452-1526
1.92e-36
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
:
Pssm-ID: 462591 Cd Length: 77 Bit Score: 132.72 E-value: 1.92e-36
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1389-1442
2.77e-29
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
:
Pssm-ID: 465306 Cd Length: 54 Bit Score: 111.59 E-value: 2.77e-29
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1547-1904
0e+00
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.
Pssm-ID: 465298 [Multi-domain] Cd Length: 355 Bit Score: 650.53 E-value: 0e+00
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1124-1380
2.66e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 224.45 E-value: 2.66e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
26-318
9.75e-65
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 220.22 E-value: 9.75e-65
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
805-1042
5.81e-50
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 177.46 E-value: 5.81e-50
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
467-698
1.59e-48
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 173.61 E-value: 1.59e-48
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1452-1526
1.92e-36
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Pssm-ID: 462591 Cd Length: 77 Bit Score: 132.72 E-value: 1.92e-36
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1389-1442
2.77e-29
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 111.59 E-value: 2.77e-29
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1504-1534
2.19e-12
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Pssm-ID: 198130 Cd Length: 31 Bit Score: 62.62 E-value: 2.19e-12
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1547-1904
0e+00
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.
Pssm-ID: 465298 [Multi-domain] Cd Length: 355 Bit Score: 650.53 E-value: 0e+00
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1124-1380
2.66e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 224.45 E-value: 2.66e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
26-318
9.75e-65
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 220.22 E-value: 9.75e-65
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
805-1042
5.81e-50
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 177.46 E-value: 5.81e-50
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
467-698
1.59e-48
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 173.61 E-value: 1.59e-48
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1452-1526
1.92e-36
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Pssm-ID: 462591 Cd Length: 77 Bit Score: 132.72 E-value: 1.92e-36
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1389-1442
2.77e-29
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 111.59 E-value: 2.77e-29
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1504-1534
2.19e-12
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Pssm-ID: 198130 Cd Length: 31 Bit Score: 62.62 E-value: 2.19e-12
Polycystin cation channel; This family contains the cation channel region from group II of ...
1153-1373
2.02e-10
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 62.68 E-value: 2.02e-10
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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