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Conserved domains on  [gi|767950358|ref|XP_011542144|]
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putative protein N-methyltransferase FAM86B1 isoform X7 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 84-211 1.62e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam10294:

Pssm-ID: 473071  Cd Length: 172  Bit Score: 69.67  E-value: 1.62e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950358   84 RTVLELGSGAGLTGLAICKMCRPRAYIFSDpHSRVLEQLRGNVLLNGLsleaditgnldSPRVTVAQLDWDVAMVHQLSA 163
Cdd:pfam10294  48 LNVLELGSGTGLVGIAVALLLPGASVTITD-LEEALELLKKNIELNAL-----------SSKVVVKVLDWGENLPPDLFD 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 767950358  164 FQP-DVVIAADVLYCPEAIVSLVGVLQRLAAcrehkRAPEVYVAFTVRN 211
Cdd:pfam10294 116 GHPvDLILAADCVYNEDSFPLLEKTLKDLLG-----KESVILVAYKKRR 159
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 84-211 1.62e-14

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 69.67  E-value: 1.62e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950358   84 RTVLELGSGAGLTGLAICKMCRPRAYIFSDpHSRVLEQLRGNVLLNGLsleaditgnldSPRVTVAQLDWDVAMVHQLSA 163
Cdd:pfam10294  48 LNVLELGSGTGLVGIAVALLLPGASVTITD-LEEALELLKKNIELNAL-----------SSKVVVKVLDWGENLPPDLFD 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 767950358  164 FQP-DVVIAADVLYCPEAIVSLVGVLQRLAAcrehkRAPEVYVAFTVRN 211
Cdd:pfam10294 116 GHPvDLILAADCVYNEDSFPLLEKTLKDLLG-----KESVILVAYKKRR 159
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 77-161 9.68e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 39.40  E-value: 9.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950358  77 TVPFPPARTVLELGSGAGLTGLAICKMCRPRAYIFSDPHSRVLEQLRGNVLLNGLS----LEADITGNLDSPRVTV---- 148
Cdd:COG2813   44 HLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLEnvevLWSDGLSGVPDGSFDLilsn 123

                         90
                 ....*....|....*..
gi 767950358 149 ----AQLDWDVAMVHQL 161
Cdd:COG2813  124 ppfhAGRAVDKEVAHAL 140
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 84-211 1.62e-14

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 69.67  E-value: 1.62e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950358   84 RTVLELGSGAGLTGLAICKMCRPRAYIFSDpHSRVLEQLRGNVLLNGLsleaditgnldSPRVTVAQLDWDVAMVHQLSA 163
Cdd:pfam10294  48 LNVLELGSGTGLVGIAVALLLPGASVTITD-LEEALELLKKNIELNAL-----------SSKVVVKVLDWGENLPPDLFD 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 767950358  164 FQP-DVVIAADVLYCPEAIVSLVGVLQRLAAcrehkRAPEVYVAFTVRN 211
Cdd:pfam10294 116 GHPvDLILAADCVYNEDSFPLLEKTLKDLLG-----KESVILVAYKKRR 159
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 87-193 1.03e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 40.43  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950358   87 LELGSGAGLTGLAICKMCRPRAYIFSDPHSRVLEQLRGNVllnglsleaditgnLDSPRVTVAQLDWDVAMVHQLSAFQP 166
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERL--------------AALGLLNAVRVELFQLDLGELDPGSF 66

                          90       100
                  ....*....|....*....|....*..
gi 767950358  167 DVVIAADVLYCPEAIVSLVGVLQRLAA 193
Cdd:pfam08242  67 DVVVASNVLHHLADPRAVLRNIRRLLK 93
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 77-161 9.68e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 39.40  E-value: 9.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950358  77 TVPFPPARTVLELGSGAGLTGLAICKMCRPRAYIFSDPHSRVLEQLRGNVLLNGLS----LEADITGNLDSPRVTV---- 148
Cdd:COG2813   44 HLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLEnvevLWSDGLSGVPDGSFDLilsn 123

                         90
                 ....*....|....*..
gi 767950358 149 ----AQLDWDVAMVHQL 161
Cdd:COG2813  124 ppfhAGRAVDKEVAHAL 140
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 78-138 1.10e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 39.36  E-value: 1.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767950358  78 VPFPPARTVLELGSGAGLTGLAICKMCrPRAYIFS---DPhsRVLEQLRGNVLLNGLS-----LEADIT 138
Cdd:COG4123   33 APVKKGGRVLDLGTGTGVIALMLAQRS-PGARITGveiQP--EAAELARRNVALNGLEdritvIHGDLK 98
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
82-194 1.19e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 37.50  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767950358  82 PARTVLELGSGAGLTGLAICKMCRPRAYIFSDPHSRVLEQLRGNVllnglsleaditgnldsPRVTVAQLDwdvamVHQL 161
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARL-----------------PNVRFVVAD-----LRDL 58

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767950358 162 SAFQP-DVVIAADVL-YCPEaivsLVGVLQRLAAC 194
Cdd:COG4106   59 DPPEPfDLVVSNAALhWLPD----HAALLARLAAA 89
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 77-153 1.28e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 38.73  E-value: 1.28e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767950358   77 TVPFPPARTVLELGSGAGLTGLAICKMCrPRAYI-FSDPHSRVLEQLRGNVLLNGLSLEADITGNLDSPrVTVAQLDW 153
Cdd:pfam05175  26 HLPKDLSGKVLDLGCGAGVLGAALAKES-PDAELtMVDINARALESARENLAANGLENGEVVASDVYSG-VEDGKFDL 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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