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Conserved domains on  [gi|767936494|ref|XP_011541932|]
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CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform X2 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 76-255 1.65e-124

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23988:

Pssm-ID: 480271  Cd Length: 278  Bit Score: 355.42  E-value: 1.65e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494  76 SLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSE 155
Cdd:cd23988    1 SLVLEIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 156 CGKEIDSHNFVI-------------------------------------------------------------------- 167
Cdd:cd23988   81 CGKEIDSHDFVIrcnlapvvefaadvgtksdfitmnpsvvqrafggfrnesdrekfvhrlsmlndsvlwipafmvkggek 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 168 ------------------------------SYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYH 217
Cdd:cd23988  161 hvewvnalilknklkvrtaypslrlihavrGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYH 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 767936494 218 YYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTT 255
Cdd:cd23988  241 YYDDLKYRYFSNAGPHRMPLEFKTLNVLHNRGALKLTT 278
 
Name Accession Description Interval E-value
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 76-255 1.65e-124

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 355.42  E-value: 1.65e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494  76 SLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSE 155
Cdd:cd23988    1 SLVLEIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 156 CGKEIDSHNFVI-------------------------------------------------------------------- 167
Cdd:cd23988   81 CGKEIDSHDFVIrcnlapvvefaadvgtksdfitmnpsvvqrafggfrnesdrekfvhrlsmlndsvlwipafmvkggek 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 168 ------------------------------SYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYH 217
Cdd:cd23988  161 hvewvnalilknklkvrtaypslrlihavrGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYH 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 767936494 218 YYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTT 255
Cdd:cd23988  241 YYDDLKYRYFSNAGPHRMPLEFKTLNVLHNRGALKLTT 278
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 96-250 8.70e-52

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 169.33  E-value: 8.70e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494   96 SVVKSSFKPGDVIHYVlDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVI-------- 167
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIrcnlaptk 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494      --------------------------------------------------------------------------------
Cdd:pfam00777  80 gyekdvgskttlrtmnpesaidskygnlgfshprdpfvefvlvpfkgrdllwlpafltkgnvsrslrvlytlkevkipvd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494  168 ----------------SYWL-TNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFpkdLNGKAVKYHYYDDLKYRYFSNA 230
Cdd:pfam00777 160 pdkvlflhpdflryvaNFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMKKGGFY 236

                         250       260
                  ....*....|....*....|
gi 767936494  231 SPHRMPLEFKTLNVLHNRGA 250
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 76-255 1.65e-124

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 355.42  E-value: 1.65e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494  76 SLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSE 155
Cdd:cd23988    1 SLVLEIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 156 CGKEIDSHNFVI-------------------------------------------------------------------- 167
Cdd:cd23988   81 CGKEIDSHDFVIrcnlapvvefaadvgtksdfitmnpsvvqrafggfrnesdrekfvhrlsmlndsvlwipafmvkggek 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 168 ------------------------------SYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYH 217
Cdd:cd23988  161 hvewvnalilknklkvrtaypslrlihavrGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYH 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 767936494 218 YYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTT 255
Cdd:cd23988  241 YYDDLKYRYFSNAGPHRMPLEFKTLNVLHNRGALKLTT 278
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 76-255 1.68e-101

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 296.63  E-value: 1.68e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494  76 SLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSE 155
Cdd:cd23969    1 TEVLRMRKWILKFFDPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 156 CGKEIDSHNFVI-------------------------------------------------------------------- 167
Cdd:cd23969   81 CGQEIDSHDFVIrcnlapvegyekdvgtksnlttmnpsviphaygdlvnatdkekfverlrqlgdsilwipafvskggee 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 168 ------------------------------SYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYH 217
Cdd:cd23969  161 hvqwtneiilkhklnvktaypplrlnhairGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYH 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 767936494 218 YYDDLKYRYfsNASPHRMPLEFKTLNVLHNRGALKLTT 255
Cdd:cd23969  241 YYDNRKYLT--TARPHKMPEEFRALRSLHQRGALRLHT 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 76-255 3.40e-96

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 283.37  E-value: 3.40e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494  76 SLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSE 155
Cdd:cd23987    1 TLSLKIRKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 156 CGKEIDSHNFVI-------------------------------------------------------------------- 167
Cdd:cd23987   81 CGREIDSHDFVIrcnlapveeyakdvgtktdlvtmnpsvvqrafedlvnetwkekflqrlqslngsilwipafmakggee 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 168 ------------------------------SYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYH 217
Cdd:cd23987  161 rvewvndlilkhhinvrtaypslrllhavrGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYH 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 767936494 218 YYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTT 255
Cdd:cd23987  241 YYDSLKYGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 78-255 2.08e-62

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 197.10  E-value: 2.08e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494  78 VLEIRKNILRFLDAERDVsVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECG 157
Cdd:cd23963    3 LDKFRKELERLLNTRKLF-LTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 158 KEIDSHNFVI---------------------------------------------------------------------- 167
Cdd:cd23963   82 KEIDSHDFVIrcnlppikgfekdvgrktnlttlnpsilkrrynslkknrdrdkflnrlkeyngsilwypkfsfksstnll 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 168 ----------------------------SYWLTNKVPiKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYY 219
Cdd:cd23963  162 lkaaralkknglnltvvysnpehflavqKFWKRRGLE-KRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYY 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 767936494 220 DDLKYRYFSNasPHRMPLEFKTLNVLHNRGALKLTT 255
Cdd:cd23963  241 DDLSPSTKNK--VHNMPEEFKLLRELHKKGVLKLHT 274
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 74-255 2.67e-53

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 174.12  E-value: 2.67e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494  74 NSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLN-ISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILL 152
Cdd:cd23970    2 NKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDYSSHKYVFsISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 153 DSECGKEIDSHNFVI----------------------------------------------------------------- 167
Cdd:cd23970   82 NSQCGNEIDKSDFVFrcnfaptegfekdvgrktnlttfnpsilekyynnlltiqdrnnfflslkkldgailwipafffht 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 168 ----------------------------------SYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKA 213
Cdd:cd23970  162 satvtrtlvdffvehrgqlkvqlawpgnimqhvnRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGTP 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 767936494 214 VKYHYYD------DLKYRYFsnaspHRMPLEFKTLNVLHNRGALKLTT 255
Cdd:cd23970  242 LPYHYYDkkgtkfTTKWQES-----HQLPAEFVLLYKMHGAGVLKLTL 284
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 96-250 8.70e-52

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 169.33  E-value: 8.70e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494   96 SVVKSSFKPGDVIHYVlDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVI-------- 167
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIrcnlaptk 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494      --------------------------------------------------------------------------------
Cdd:pfam00777  80 gyekdvgskttlrtmnpesaidskygnlgfshprdpfvefvlvpfkgrdllwlpafltkgnvsrslrvlytlkevkipvd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494  168 ----------------SYWL-TNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFpkdLNGKAVKYHYYDDLKYRYFSNA 230
Cdd:pfam00777 160 pdkvlflhpdflryvaNFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMKKGGFY 236

                         250       260
                  ....*....|....*....|
gi 767936494  231 SPHRMPLEFKTLNVLHNRGA 250
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 105-253 8.00e-44

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 149.33  E-value: 8.00e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 105 GDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVI----------------- 167
Cdd:cd23971   30 GSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIrcnlpplndskdvgskt 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 168 ------------------------------------------------------------------------------SY 169
Cdd:cd23971  110 nlvtanpsilrekfhnlkkrrrpfvermkvygnallllpafsytsntepslralytledfgspqkvlffnpeylrnlsRY 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 170 WLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKyryfSNASPHRMPLEFKTLNVLHNRG 249
Cdd:cd23971  190 WKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHYYDNVL----PKKGVHAMPEEFLRYLKLHSQG 265


                 ....
gi 767936494 250 ALKL 253
Cdd:cd23971  266 VLRL 269
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 82-253 1.32e-27

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 106.84  E-value: 1.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494  82 RKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKnRRFKTCAVVGNSGILLDSECGKEID 161
Cdd:cd23989    7 RKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQQID 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 162 SHNFVI-------------------------------------------------------------------------- 167
Cdd:cd23989   86 RADFVMrcnlpplsreytddvgtktqlvtanpsiidkrfqnllwsrksfvesmkvygrsyiympafsmktgtdpslrvyy 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 168 -----------------------SYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLky 224
Cdd:cd23989  166 tladvganqtvlfanpnflrnvgKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNV-- 243

                        250       260
                 ....*....|....*....|....*....
gi 767936494 225 ryFSNASPHRMPLEFKTLNVLHNRGALKL 253
Cdd:cd23989  244 --LPDSGFHAMPEEFLQLWHLHKSGVLRM 270
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 105-255 1.21e-25

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 101.84  E-value: 1.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 105 GDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIS---------------- 168
Cdd:cd23990   30 GTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRcnlppisekyvrdvgv 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494     --------------------------------------------------------------------------------
Cdd:cd23990  110 ktdvvtinpsiiterfhklekwrrpfyevlqvyenasvvlpafyntrntdvsirvkyvlddfesqqavyyfhpqyllnvs 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 169 -YWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRyfsnASPHRMPLEFKTLNVLHN 247
Cdd:cd23990  190 rFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYYDNVKPR----PGFHAMPSEIFNFLHMHS 265


                 ....*...
gi 767936494 248 RGALKLTT 255
Cdd:cd23990  266 RGILRVHT 273
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 105-253 2.06e-25

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 100.98  E-value: 2.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 105 GDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFV------------------ 166
Cdd:cd23991   30 GTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVfrcnlpptggniskdvgs 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 167 -----------IS------------------------------------------------------------------- 168
Cdd:cd23991  110 ktnlvtanpsiISikyaklnerrkpfletvsvygdaflllpafsyrsntalsfkvyytledfkakqkviffhpiylkhla 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 169 -YWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLkyryFSNASPHRMPLEFKTLNVLHN 247
Cdd:cd23991  190 qFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQ----LPKPGFHSMPKEFYQLLQLHS 265


                 ....*.
gi 767936494 248 RGALKL 253
Cdd:cd23991  266 KGILKL 271
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 142-245 1.86e-16

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 75.09  E-value: 1.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 142 CAVVGNSGILLDSECGKEIDSHNFVI------------------SYWLTN------------------------------ 173
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFrfnqaptkgfekdvgsktTFRVLNskwagfylrgprcgchplpleeevvlilsr 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 174 -----------------KVPIK----------------------------RPSTGLLMYTLATRFCDEIHLYGFWPFPKD 208
Cdd:cd19952   81 aaaadfkrlkrrkkrhdNAVLLltdpapdllsyvrkrleklglksffggnAPSSGLLAVLLALQLCDSVDLYGFGVDSGH 160

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 767936494 209 lnGKAVKYHYYDdlKYRYFSNASPHRMPLEFKTLNVL 245
Cdd:cd19952  161 --APKVPYHYYD--LVEAEEGTAVHSFDLEAELLRAL 193
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 130-253 2.14e-09

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 56.52  E-value: 2.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 130 EVSPMKNR-------RFKTCAVVGNSGILLDSECGKEIDSHNFVI--------------------------SY------- 169
Cdd:cd23966   61 QVVPGENPyrtrdpnRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIrmnkaptkgfekdvgsktthhfmypeSAvdldpgv 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 170 -------------WLT-----------------------NKVPI------------------KRPSTGLLMYTLATRFCD 195
Cdd:cd23966  141 hlvlvpfkvldlqWLIsalttgeitrtytpvkrfikadkDKVLVinpafikyvhdnwtehhgRYPSTGFLALIFALHICD 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767936494 196 EIHLYGF-------WpfpkdlngkavkYHYYDDLKYRY-FSNASPHRMPLEFKTLNVLHNRGALKL 253
Cdd:cd23966  221 EVSVFGFgadskgnW------------HHYWEKNRSAGaFRKTGVHDADFESDIIKKLAKEGKIRV 274
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 166-223 4.21e-08

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 52.29  E-value: 4.21e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767936494 166 VISYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNgkaVKYHYYDDLK 223
Cdd:cd23967  129 LIGLPMNGKQGKNVPTTGIIAIVMALHYCDEVDIAGFGYDPSDPN---APLHYYDSLT 183
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 141-253 4.71e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 52.65  E-value: 4.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 141 TCAVVGNSGILLDSECGKEIDSHNFV------------------------------------------ISY--------- 169
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVfrvnhaltkgfekdvgtktsfytffpeslhnsllkhvpqdkdTKYlfipfkird 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 170 ------WLTNK-VP------------------------------------------IKRPSTGLLMYTLATRFCDEIHLY 200
Cdd:cd23964  164 ydyldaVLSGKpVPdgcdkgkrppplfgpklnatnvrllhpdfirylfnrwlnsstSYRPTTGALMLLTALHTCDQVSVY 243

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767936494 201 GFwpfpkdlnGKAVKY--HYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKL 253
Cdd:cd23964  244 GF--------GYDPRFslHYYDKTFVKFTVFYANHDFTNERKLWRKLHEEGIINL 290
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 128-167 7.72e-08

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 51.89  E-value: 7.72e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767936494 128 LPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVI 167
Cdd:cd23968   34 FPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVL 73
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 124-166 1.12e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 48.59  E-value: 1.12e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767936494 124 LHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFV 166
Cdd:cd23973   68 KEQQLLALSPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYV 110
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 123-179 4.19e-06

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 46.80  E-value: 4.19e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767936494 123 DLHSLLP-EVSPMKNRRF---KTCAVVGNSGILLDSECGKEIDSHNFVISywlTNKVPIKR 179
Cdd:cd23980   61 ELFQVVPgNVDPLLEKRLvscRRCAVVGNSGNLKESYYGPQIDSHDFVLR---MNKAPTEG 118
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 131-178 1.64e-05

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 45.21  E-value: 1.64e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 767936494 131 VSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVISYwltNKVPIK 178
Cdd:cd23986   41 LSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRF---NSAPTR 85
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 137-234 2.66e-05

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 44.31  E-value: 2.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 137 RRFKTCAVVGNSGILLDSECGKEIDSHNFVISYwltNKVPIK------------RPSTGLLMYTLATRFCDEiHLYGF-- 202
Cdd:cd23985   43 GPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRF---NGAPTAgfqqdvgtkttiRLINSQLVTTEKHKFLKD-SLYNEgi 118

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767936494 203 ---W---PFPKDLNgkavkyHYYDDLKYRYFSNASPHR 234
Cdd:cd23985  119 livWdpaPYHSDIP------EWYKNPDYNFFENYKTYR 150
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 177-253 4.31e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 43.97  E-value: 4.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 177 IKRPSTGLLMYTLATRFCDEIHLYGFwpFPKDLNgkavKY--HYYDDL--KYRYFSNaspHRMPLEFKTLNVLHNRGALK 252
Cdd:cd23974  236 IYRPSTGAVMLLAALHTCDQVSAYGF--MTPDYG----KYsdHYYDKTyhKVVFYAN---HDLRLEMQLWQKLHKAGLIK 306


                 .
gi 767936494 253 L 253
Cdd:cd23974  307 L 307
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 179-242 5.12e-05

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 43.11  E-value: 5.12e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767936494 179 RPSTGLLMYTLATRFCDEIHLYGF-WPfpkDLNGKAVKYHYYDDLKYRYFSNaSPHRMPLEFKTL 242
Cdd:cd23982  141 KPTTGLLAITLALHLCDEVHIAGFgYP---DNGNSNQPIHYYNQITLKSMAN-SGHNLNAEAQAI 201
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 113-166 6.92e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 43.20  E-value: 6.92e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767936494 113 DRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFV 166
Cdd:cd23974   58 DALNLLNSSANGQMFDWWDRPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYV 111
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 81-167 7.35e-05

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 43.32  E-value: 7.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494  81 IRKNILRFLDAERDVSVVKSSFKPGDvIHYVLDRrrtlnishdLHSLLPEVSPMKNR---RFKTCAVVGNSGILLDSECG 157
Cdd:cd23979   29 TKENMELPPDVQYWWMMLQPQFKPHN-TKEVLSK---------LFQIIPGENPYRSWdpsRCRRCAVVGNSGNLRGSGYG 98

                         90
                 ....*....|
gi 767936494 158 KEIDSHNFVI 167
Cdd:cd23979   99 KDIDGHDFIM 108
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 180-253 1.74e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 42.12  E-value: 1.74e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767936494 180 PSTGLLMYTLATRFCDEIHLYGFWpfpkDLNGKAVKYHYYDDLK--YRYFSNaspHRMPLEFKTLNVLHNRGALKL 253
Cdd:cd23972  237 PSTGALMLLTALHTCDQVSAYGFI----TSNYWKFSDHYYERKKkpLVFYAN---HDMLLEAALWRRLHKAGILQL 305
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 116-166 2.59e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 41.73  E-value: 2.59e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767936494 116 RTLNISHDLHSLLPEVSPMKNRRfktCAVVGNSGILLDSECGKEIDSHNFV 166
Cdd:cd23972   62 SLLNDSANAKLFFPRDTPGKCIR---CAVVGNGGILNGSRQGRAIDAHDYV 109
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 181-222 3.54e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 41.01  E-value: 3.54e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767936494 181 STGLLMYTLATRFCDEIHLYGFWP--FPKDLNGKAVKYHYYDDL 222
Cdd:cd23976  154 STGWFTMIIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPS 197
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 140-167 6.93e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 39.92  E-value: 6.93e-04
                         10        20
                 ....*....|....*....|....*...
gi 767936494 140 KTCAVVGNSGILLDSECGKEIDSHNFVI 167
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVI 29
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 169-253 1.19e-03

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 39.73  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 169 YWLtnkvpIKRPSTGLLMYTLATRFCDEIHLYGFwpfpkdLNGKAVKY--HYYDDLKYR--YFSNaspHRMPLEFKTLNV 244
Cdd:cd23973  232 YWA-----IYRPTTGAFLLLTALHLCDTVSAYGF------ITEDYRKYpdHYYDKKKTKlvFYIN---HDFRLEKKLWKR 297


                 ....*....
gi 767936494 245 LHNRGALKL 253
Cdd:cd23973  298 LHDEKIIKL 306
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 181-225 4.20e-03

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 37.61  E-value: 4.20e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767936494 181 STGLLMYTLATRFCDEIHLYGFWP--FPKDLNGKAVKYHYYDDLKYR 225
Cdd:cd23965  140 STGWFTMLLALDVCDEIKVYGMVPenYCREHPNSKVPYHYYEPGGLK 186
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 140-167 5.88e-03

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 37.03  E-value: 5.88e-03
                         10        20
                 ....*....|....*....|....*...
gi 767936494 140 KTCAVVGNSGILLDSECGKEIDSHNFVI 167
Cdd:cd23984    3 KKCVVVGNGGVLRNKSLGKKIDSYDVII 30
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 131-220 6.01e-03

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 37.14  E-value: 6.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936494 131 VSPMKNRRFKTcavvgnsgiLLDSECGKEID-SHNfvisyWLtnkvpikrpSTGLLMYTLATRFCDEIHLYGFWPF---P 206
Cdd:cd23978  112 VSPRRMRQFDD---------LFRGETGRDRKkSHS-----WL---------STGWFTMVIAVELCDNVHVYGMVPPnycS 168

                         90
                 ....*....|....
gi 767936494 207 KDLNGKAVKYHYYD 220
Cdd:cd23978  169 KRPTPKKMPYHYYE 182
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 180-245 7.80e-03

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 36.64  E-value: 7.80e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767936494 180 PSTGLLMYTLATRFCDEIHLYGfwpFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVL 245
Cdd:cd23983  149 PTLGVTAVVLATHLCDEVSLAG---FGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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