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repulsive guidance molecule B isoform X4 [Homo sapiens]
repulsive guidance molecule family protein( domain architecture ID 10534812)
repulsive guidance molecule (RGM) family protein may have several functions in the developing and adult nervous system, including regulation of cephalic neural tube closure, inhibition of neurite outgrowth and cortical neuron branching, and the formation of mature synapses
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
RGM_C | pfam06534 | Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and ... |
185-359 | 1.23e-106 | ||||
Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum. : Pssm-ID: 461939 Cd Length: 171 Bit Score: 311.10 E-value: 1.23e-106
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RGM_N | pfam06535 | Repulsive guidance molecule (RGM) N-terminus; This family consists of the N-terminal region of ... |
13-180 | 2.15e-90 | ||||
Repulsive guidance molecule (RGM) N-terminus; This family consists of the N-terminal region of several mammalian and one bird sequence from Gallus gallus (Chicken). All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum. : Pssm-ID: 461940 Cd Length: 165 Bit Score: 269.61 E-value: 2.15e-90
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Name | Accession | Description | Interval | E-value | ||||
RGM_C | pfam06534 | Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and ... |
185-359 | 1.23e-106 | ||||
Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum. Pssm-ID: 461939 Cd Length: 171 Bit Score: 311.10 E-value: 1.23e-106
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RGM_N | pfam06535 | Repulsive guidance molecule (RGM) N-terminus; This family consists of the N-terminal region of ... |
13-180 | 2.15e-90 | ||||
Repulsive guidance molecule (RGM) N-terminus; This family consists of the N-terminal region of several mammalian and one bird sequence from Gallus gallus (Chicken). All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum. Pssm-ID: 461940 Cd Length: 165 Bit Score: 269.61 E-value: 2.15e-90
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Name | Accession | Description | Interval | E-value | ||||
RGM_C | pfam06534 | Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and ... |
185-359 | 1.23e-106 | ||||
Repulsive guidance molecule (RGM) C-terminus; This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum. Pssm-ID: 461939 Cd Length: 171 Bit Score: 311.10 E-value: 1.23e-106
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RGM_N | pfam06535 | Repulsive guidance molecule (RGM) N-terminus; This family consists of the N-terminal region of ... |
13-180 | 2.15e-90 | ||||
Repulsive guidance molecule (RGM) N-terminus; This family consists of the N-terminal region of several mammalian and one bird sequence from Gallus gallus (Chicken). All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum. Pssm-ID: 461940 Cd Length: 165 Bit Score: 269.61 E-value: 2.15e-90
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