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Conserved domains on  [gi|767906367|ref|XP_011540584|]
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volume-regulated anion channel subunit LRRC8C isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-338 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 593.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367    1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSNVSQAVASTTP 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367   81 LPPPKPSPANPITvEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS 160
Cdd:pfam12534  81 APTVSSPSASMIP-EPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  161 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQSGPEDSLVNSQSLKSIPEKFVVD-KSTAGALDK 232
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 312
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 767906367  313 AHLFSKLSFCYLCFVSIYGLTCLYTL 338
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-772 7.75e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.84  E-value: 7.75e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 582 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 661
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 662 LERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 767906367 742 SVLsPKIGNLLFLSYLDVKGNHFEILPPELG 772
Cdd:COG4886  241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 512-622 2.75e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 512 GLRNLEELYLVGSLshdISRNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 587
Cdd:cd21340   66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767906367 588 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 622
Cdd:cd21340  141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-338 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 593.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367    1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSNVSQAVASTTP 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367   81 LPPPKPSPANPITvEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS 160
Cdd:pfam12534  81 APTVSSPSASMIP-EPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  161 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQSGPEDSLVNSQSLKSIPEKFVVD-KSTAGALDK 232
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 312
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 767906367  313 AHLFSKLSFCYLCFVSIYGLTCLYTL 338
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-772 7.75e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.84  E-value: 7.75e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 582 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 661
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 662 LERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 767906367 742 SVLsPKIGNLLFLSYLDVKGNHFEILPPELG 772
Cdd:COG4886  241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 585-764 1.74e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 1.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 585 LKKMTNLTeleLVHCDLERIPhaVFSLL-SLQELDLKENNLKSIEeivSFQHLRKLTVLKLWHNSITYIpEHIKKLTSLE 663
Cdd:cd21340    1 LKRITHLY---LNDKNITKID--NLSLCkNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 664 RLSFSHNKIEVLpSHLFLCNKIRYLDLSYNDIrfiPPE----------IGVLQSLQYFSITCNKVESLpDELYFCKKLKT 733
Cdd:cd21340   72 KLYLGGNRISVV-EGLENLTNLEELHIENQRL---PPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQ 146

                        170       180       190
                 ....*....|....*....|....*....|....
gi 767906367 734 LKIGKN---SLSVLSPKIGNLLFLSYLDVKGNHF 764
Cdd:cd21340  147 LDASNNqisDLEELLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 441-777 2.00e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 2.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 441 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELSLHQ--CSVKIHSAALSFLKenlkVLSVKFDDMR---ELPPWMY 511
Cdd:PLN00113 230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYLFLYQnkLSGPIPPSIFSLQK----LISLDLSDNSlsgEIPELVI 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 512 GLRNLEELYLvgsLSHDISRNVTlESLRDLKSLKILSIKSN--VSKIPQavvdvssHLQKmciHNDGTKLVMLNN----- 584
Cdd:PLN00113 306 QLQNLEILHL---FSNNFTGKIP-VALTSLPRLQVLQLWSNkfSGEIPK-------NLGK---HNNLTVLDLSTNnltge 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 585 ----LKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDLKENNLkSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEHIKK 658
Cdd:PLN00113 372 ipegLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD 450

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 659 LTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELYFCKKLKTLKI 736
Cdd:PLN00113 451 MPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDL 530

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 767906367 737 GKNSLSVLSP-KIGNLLFLSYLDVKGNHFE-ILPPELGDCRAL 777
Cdd:PLN00113 531 SHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
LRR_8 pfam13855
Leucine rich repeat;
637-695 1.30e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.30e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767906367  637 RKLTVLKLWHNSITYI-PEHIKKLTSLERLSFSHNKIEVLPSHLFLC-NKIRYLDLSYNDI 695
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 512-622 2.75e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 512 GLRNLEELYLVGSLshdISRNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 587
Cdd:cd21340   66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767906367 588 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 622
Cdd:cd21340  141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 425-733 6.87e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 40.24  E-value: 6.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSvkihsaalsflkenlkvlsvkfdDMR 504
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCS-----------------------SLV 671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  505 ELPPWMYGLRNLEELylvgslshDISRNVTLESLR---DLKSLKILSIkSNVSKIpQAVVDVSSHLQKMCIhnDGTKLVM 581
Cdd:PLN03210  672 ELPSSIQYLNKLEDL--------DMSRCENLEILPtgiNLKSLYRLNL-SGCSRL-KSFPDISTNISWLDL--DETAIEE 739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  582 LNNLKKMTNLTELELVHCDLERIPHAVFSLL--------SLQELDLkeNNLKSIEEI-VSFQHLRKLTVLKLWH-NSITY 651
Cdd:PLN03210  740 FPSNLRLENLDELILCEMKSEKLWERVQPLTplmtmlspSLTRLFL--SDIPSLVELpSSIQNLHKLEHLEIENcINLET 817

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  652 IPEHIkKLTSLERLSFSH-NKIEVLPShlfLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS-ITCNKVESLPDELYFCK 729
Cdd:PLN03210  818 LPTGI-NLESLESLDLSGcSRLRTFPD---ISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDmNGCNNLQRVSLNISKLK 893


                  ....
gi 767906367  730 KLKT 733
Cdd:PLN03210  894 HLET 897
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-338 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 593.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367    1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSNVSQAVASTTP 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367   81 LPPPKPSPANPITvEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS 160
Cdd:pfam12534  81 APTVSSPSASMIP-EPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  161 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQSGPEDSLVNSQSLKSIPEKFVVD-KSTAGALDK 232
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 312
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 767906367  313 AHLFSKLSFCYLCFVSIYGLTCLYTL 338
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-772 7.75e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.84  E-value: 7.75e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 582 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 661
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 662 LERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741
Cdd:COG4886  161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                        170       180       190
                 ....*....|....*....|....*....|.
gi 767906367 742 SVLsPKIGNLLFLSYLDVKGNHFEILPPELG 772
Cdd:COG4886  241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
515-779 2.04e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 127.74  E-value: 2.04e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 515 NLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTEL 594
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 595 ELVHCDLerIPHAVFSLLSLQELDLKENNlksieeivSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEV 674
Cdd:COG4886   81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 675 LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFL 754
Cdd:COG4886  151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                        250       260
                 ....*....|....*....|....*
gi 767906367 755 SYLDVKGNHFEILpPELGDCRALKR 779
Cdd:COG4886  231 ETLDLSNNQLTDL-PELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
398-771 9.94e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.88  E-value: 9.94e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 398 NKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQC 477
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 478 SVKIHSAALSFLKENLKVLSVKFDDMRELppwmYGLRNLEELYLVGSLSHDISrnvtlESLRDLKSLKILSIKSN-VSKI 556
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEEL----SNLTNLESLDLSGNQLTDLP-----EELANLTNLKELDLSNNqLTDL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 557 PqavvdvsshlqkmcihndgtklvmlNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEivSFQHL 636
Cdd:COG4886  152 P-------------------------EPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--PLGNL 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 637 RKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPShLFLCNKIRYLDLSYNDIRFIPPEIGvLQSLQYFSITCN 716
Cdd:COG4886  205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNN 282

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767906367 717 KVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPEL 771
Cdd:COG4886  283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
356-758 1.29e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 1.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 356 QETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSG 435
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 436 LPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKeNLKVLSVKFDDMRELPPWMYGLRN 515
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPEPLGNLTN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 516 LEELYLVGSLSHDISrnvtlESLRDLKSLKILSIKSN-VSKIPQAvvdvsshlqkmcihndgtklvmlnnLKKMTNLTEL 594
Cdd:COG4886  161 LKSLDLSNNQLTDLP-----EELGNLTNLKELDLSNNqITDLPEP-------------------------LGNLTNLEEL 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 595 ELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIvsfQHLRKLTVLKLWHNSITYIPEhIKKLTSLERLSFSHNKIEV 674
Cdd:COG4886  211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTD 286

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 675 LP-SHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLF 753
Cdd:COG4886  287 LKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366


                 ....*
gi 767906367 754 LSYLD 758
Cdd:COG4886  367 LTLGL 371
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 585-764 1.74e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 1.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 585 LKKMTNLTeleLVHCDLERIPhaVFSLL-SLQELDLKENNLKSIEeivSFQHLRKLTVLKLWHNSITYIpEHIKKLTSLE 663
Cdd:cd21340    1 LKRITHLY---LNDKNITKID--NLSLCkNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 664 RLSFSHNKIEVLpSHLFLCNKIRYLDLSYNDIrfiPPE----------IGVLQSLQYFSITCNKVESLpDELYFCKKLKT 733
Cdd:cd21340   72 KLYLGGNRISVV-EGLENLTNLEELHIENQRL---PPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQ 146

                        170       180       190
                 ....*....|....*....|....*....|....
gi 767906367 734 LKIGKN---SLSVLSPKIGNLLFLSYLDVKGNHF 764
Cdd:cd21340  147 LDASNNqisDLEELLDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 441-777 2.00e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 2.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 441 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELSLHQ--CSVKIHSAALSFLKenlkVLSVKFDDMR---ELPPWMY 511
Cdd:PLN00113 230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYLFLYQnkLSGPIPPSIFSLQK----LISLDLSDNSlsgEIPELVI 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 512 GLRNLEELYLvgsLSHDISRNVTlESLRDLKSLKILSIKSN--VSKIPQavvdvssHLQKmciHNDGTKLVMLNN----- 584
Cdd:PLN00113 306 QLQNLEILHL---FSNNFTGKIP-VALTSLPRLQVLQLWSNkfSGEIPK-------NLGK---HNNLTVLDLSTNnltge 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 585 ----LKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDLKENNLkSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEHIKK 658
Cdd:PLN00113 372 ipegLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD 450

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 659 LTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELYFCKKLKTLKI 736
Cdd:PLN00113 451 MPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDL 530

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 767906367 737 GKNSLSVLSP-KIGNLLFLSYLDVKGNHFE-ILPPELGDCRAL 777
Cdd:PLN00113 531 SHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 543-795 1.11e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.17  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 543 SLKILSIKSNV--SKIPQAVVDVSShLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDL 619
Cdd:PLN00113 165 SLKVLDLGGNVlvGKIPNSLTNLTS-LEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 620 KENNLkSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEHIKKLTSLERLSFSHNKIE-VLPSHLFLCNKIRYLDLSYNDIR- 696
Cdd:PLN00113 244 VYNNL-TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTg 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 697 FIPPEIGVLQSLQYFSITCNKVE-SLPDELYFCKKLKTLKIGKNSLSVLSPKI----GNL----LFLSYLDVKgnhfeiL 767
Cdd:PLN00113 323 KIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEGlcssGNLfkliLFSNSLEGE------I 396

                        250       260
                 ....*....|....*....|....*...
gi 767906367 768 PPELGDCRALKRAGLvVEDALFETLPSD 795
Cdd:PLN00113 397 PKSLGACRSLRRVRL-QDNSFSGELPSE 423
LRR_8 pfam13855
Leucine rich repeat;
637-695 1.30e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.30e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767906367  637 RKLTVLKLWHNSITYI-PEHIKKLTSLERLSFSHNKIEVLPSHLFLC-NKIRYLDLSYNDI 695
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 603-778 3.54e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 3.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 603 RIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSIT-YIPEhiKKLTSLERLSFSHNKIE-VLPSHLF 680
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 681 LCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNK-VESLPDELYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYL 757
Cdd:PLN00113 162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSGEIPYeIGGLTSLNHL 241

                        170       180
                 ....*....|....*....|..
gi 767906367 758 D-VKGNHFEILPPELGDCRALK 778
Cdd:PLN00113 242 DlVYNNLTGPIPSSLGNLKNLQ 263
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
581-801 5.27e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.63  E-value: 5.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 581 MLNNLKKmtNLTELELVHCDLERIPHAVFSllSLQELDLKENNLKSIEEIVSfQHLRKLTVLKlwhNSITYIPEHIKKlt 660
Cdd:PRK15370 172 MRDCLKN--NKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQ-GNIKTLYANS---NQLTSIPATLPD-- 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 661 SLERLSFSHNKIEVLPSHLflcnkiryldlsyndirfipPeigvlQSLQYFSITCNKVESLPDELyfCKKLKTLKIGKNS 740
Cdd:PRK15370 242 TIQEMELSINRITELPERL--------------------P-----SALQSLDLFHNKISCLPENL--PEELRYLSVYDNS 294

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767906367 741 LSVLSPKIGNllFLSYLDVKGNHFEILPPELgdcrALKRAGLVVEDALFETLPSDVREQMK 801
Cdd:PRK15370 295 IRTLPAHLPS--GITHLNVQSNSLTALPETL----PPGLKTLEAGENALTSLPASLPPELQ 349
LRR_8 pfam13855
Leucine rich repeat;
589-649 7.70e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 7.70e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767906367  589 TNLTELELVHCDLERIPHAVFS-LLSLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWHNSI 649
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
613-672 2.98e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767906367  613 SLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWHNSITYI-PEHIKKLTSLERLSFSHNKI 672
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 513-687 3.66e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 3.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 513 LRNLEELYLvgslSH-DISRnvtLESLRDLKSLKILsiksnvskipqavvdvssHLQKMCIhndgtklVMLNNLKKMTNL 591
Cdd:cd21340   45 LTNLTHLYL----QNnQIEK---IENLENLVNLKKL------------------YLGGNRI-------SVVEGLENLTNL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 592 TELelvHCDLERI---------PHAVFSLL-SLQELDLKENNLKSIEEivsFQHLRKLTVLKLWHNSITYIPE---HIKK 658
Cdd:cd21340   93 EEL---HIENQRLppgekltfdPRSLAALSnSLRVLNISGNNIDSLEP---LAPLRNLEQLDASNNQISDLEElldLLSS 166

                        170       180
                 ....*....|....*....|....*....
gi 767906367 659 LTSLERLSFSHNKIevlpshlflCNKIRY 687
Cdd:cd21340  167 WPSLRELDLTGNPV---------CKKPKY 186
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
449-725 1.60e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 1.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 449 LKLEIIKNVMIPATIAQ------LDNLQELSLHQCsvkihsaalsfLKENLKVLSVKFDDMRELPPWMYGlrNLEELylv 522
Cdd:PRK15370 183 LRLKILGLTTIPACIPEqittliLDNNELKSLPEN-----------LQGNIKTLYANSNQLTSIPATLPD--TIQEM--- 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 523 gslshDISRNVTLESLRDLKS-LKILSIKSN-VSKIPQAVVDvssHLQKMCIHNdgtklvmlNNLKKMTnltelelvhcd 600
Cdd:PRK15370 247 -----ELSINRITELPERLPSaLQSLDLFHNkISCLPENLPE---ELRYLSVYD--------NSIRTLP----------- 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 601 lERIPHavfsllSLQELDLKENNLKSIEEIVSFQhlrkLTVLKLWHNSITYIPEHIKKltSLERLSFSHNKIEVLPSHlf 680
Cdd:PRK15370 300 -AHLPS------GITHLNVQSNSLTALPETLPPG----LKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVLPET-- 364

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 767906367 681 LCNKIRYLDLSYNDIRFIPPEIGVlqSLQYFSITCNKVESLPDEL 725
Cdd:PRK15370 365 LPPTITTLDVSRNALTNLPENLPA--ALQIMQASRNNLVRLPESL 407
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 582-743 2.23e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.94  E-value: 2.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 582 LNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL--KSIEEIVS-FQHLRKLTVLKLWHNSIT-----YIP 653
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIGdegviALA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 654 EHIKKLTSLERLSFSHNKIEV-----LPSHLFLCNKIRYLDLSYNDIRFiPPEIGVLQSLQ-----------YFSITCNK 717
Cdd:COG5238  258 EALKNNTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGD-EGAIALAEGLQgnktlhtlnlaYNGIGAQG 336

                        170       180
                 ....*....|....*....|....*.
gi 767906367 718 VESLPDELYFCKKLKTLKIGKNSLSV 743
Cdd:COG5238  337 AIALAKALQENTTLHSLDLSDNQIGD 362
PLN03150 PLN03150
hypothetical protein; Provisional
 604-670 5.07e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 5.07e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767906367 604 IPHAVFSLLSLQELDLKENNLKSieEI-VSFQHLRKLTVLKLWHNSIT-YIPEHIKKLTSLERLSFSHN 670
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRG--NIpPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
706-764 1.62e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767906367  706 QSLQYFSITCNKVESLPDE-LYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYLDVKGNHF 764
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 512-622 2.75e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 512 GLRNLEELYLVGSLshdISRNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 587
Cdd:cd21340   66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767906367 588 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 622
Cdd:cd21340  141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 425-733 6.87e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 40.24  E-value: 6.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSvkihsaalsflkenlkvlsvkfdDMR 504
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCS-----------------------SLV 671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  505 ELPPWMYGLRNLEELylvgslshDISRNVTLESLR---DLKSLKILSIkSNVSKIpQAVVDVSSHLQKMCIhnDGTKLVM 581
Cdd:PLN03210  672 ELPSSIQYLNKLEDL--------DMSRCENLEILPtgiNLKSLYRLNL-SGCSRL-KSFPDISTNISWLDL--DETAIEE 739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  582 LNNLKKMTNLTELELVHCDLERIPHAVFSLL--------SLQELDLkeNNLKSIEEI-VSFQHLRKLTVLKLWH-NSITY 651
Cdd:PLN03210  740 FPSNLRLENLDELILCEMKSEKLWERVQPLTplmtmlspSLTRLFL--SDIPSLVELpSSIQNLHKLEHLEIENcINLET 817

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367  652 IPEHIkKLTSLERLSFSH-NKIEVLPShlfLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS-ITCNKVESLPDELYFCK 729
Cdd:PLN03210  818 LPTGI-NLESLESLDLSGcSRLRTFPD---ISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDmNGCNNLQRVSLNISKLK 893


                  ....
gi 767906367  730 KLKT 733
Cdd:PLN03210  894 HLET 897
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 583-696 7.48e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.77  E-value: 7.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906367 583 NNLKKMTNLTELELVHCDL-ERIPHAVFSLL----SLQELDLKENNLKSIEEIVSFQHL---RKLTVLKLWHNSIT---- 650
Cdd:COG5238  286 KALQGNTTLTSLDLSVNRIgDEGAIALAEGLqgnkTLHTLNLAYNGIGAQGAIALAKALqenTTLHSLDLSDNQIGdega 365

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767906367 651 -YIPEHIKKLTSLERLSFSHNKI-----EVLPSHLfLCNKIRYLDLSYNDIR 696
Cdd:COG5238  366 iALAKYLEGNTTLRELNLGKNNIgkqgaEALIDAL-QTNRLHTLILDGNLIG 416
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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