|
Name |
Accession |
Description |
Interval |
E-value |
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
60-245 |
1.92e-26 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 116.50 E-value: 1.92e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 60 AMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVAL-FLYhvV 138
Cdd:COG1033 188 AIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--L 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 139 FGIQyLGILNGVAAFVIVGIGVDDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVH 217
Cdd:COG1033 266 LGIP-LSPLTILVPPLLLAIGIDYGIHLLNRYREERrKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIR 344
|
170 180
....*....|....*....|....*...
gi 767905250 218 DFGLFMSLIVSCCWLAVLVTMPAALGLW 245
Cdd:COG1033 345 DFGIVAAIGVLLAFLTSLTLLPALLSLL 372
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
816-973 |
1.14e-12 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 72.20 E-value: 1.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 816 LVLSLLICVAAVAVFTTHILLLLPvllsilGIVCLVVTI------MYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYL 889
Cdd:COG1033 224 FPLALLLILLLLFLFFRSLRGVLL------PLLVVLLAViwtlglMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYR 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 890 -LAGENLPPHQAedARtqrqwrtlEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTA 968
Cdd:COG1033 298 eERRKGLDKREA--LR--------EALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPA 367
|
....*
gi 767905250 969 LLGIM 973
Cdd:COG1033 368 LLSLL 372
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
114-244 |
2.16e-12 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 65.68 E-value: 2.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 114 VFLSFFGIASIGLS--CLVALFLYhvvFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAG 191
Cdd:pfam12349 6 FGLGLAGVIIVLASvaSSLGLCAY---FGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGEVG 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 767905250 192 KATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 244
Cdd:pfam12349 83 PSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSL 135
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
70-244 |
1.31e-10 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 65.63 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 70 VQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALfLYHVVFGIQYLGILNG 149
Cdd:TIGR00921 547 VKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAI-GLMGLRGIPSFLAMAT 625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 150 VAAfVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSC 229
Cdd:TIGR00921 626 TIS-IILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLS 704
|
170
....*....|....*
gi 767905250 230 CWLAVLVTMPAALGL 244
Cdd:TIGR00921 705 SLTAALVVFPALLVL 719
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
848-970 |
2.22e-07 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 54.84 E-value: 2.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 848 VCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYllagenlpPHQAEDARTQRQwRTLEAVRHVGVAIVSSAL 927
Cdd:TIGR00921 231 VAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRY--------EEERDIGRAKGE-AIVTAVRRTGRAVLIALL 301
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 767905250 928 TTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALL 970
Cdd:TIGR00921 302 TTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALL 344
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
853-973 |
9.40e-05 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 46.52 E-value: 9.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 853 TIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEgyllageNLPPHQAEDARTQRQwRTLEAVRHVGVAIVSSALTTVIA 932
Cdd:pfam00873 374 AVMKAFGFSINTLTLGGLVLAIGLVVDDAIVVVE-------NIERVLEENGLKPLE-AAYKSMGEIGGALVAIALVLSAV 445
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 767905250 933 TVPLFF---CIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIM 973
Cdd:pfam00873 446 FLPILFlggLTGRIFRQFAITIVLAILLSVLVALTLTPALCATL 489
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
60-245 |
1.92e-26 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 116.50 E-value: 1.92e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 60 AMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVAL-FLYhvV 138
Cdd:COG1033 188 AIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--L 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 139 FGIQyLGILNGVAAFVIVGIGVDDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVH 217
Cdd:COG1033 266 LGIP-LSPLTILVPPLLLAIGIDYGIHLLNRYREERrKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIR 344
|
170 180
....*....|....*....|....*...
gi 767905250 218 DFGLFMSLIVSCCWLAVLVTMPAALGLW 245
Cdd:COG1033 345 DFGIVAAIGVLLAFLTSLTLLPALLSLL 372
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
15-245 |
2.72e-18 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 90.30 E-value: 2.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 15 SADNLKSSLLRSEILFGAPLPNYYSVD---------------DRWEEQRAKFQSFVVTYVAmlakqsTSKVQVLYGGTDL 79
Cdd:COG1033 521 SRELLAQLLLLLSSPPGDDLSRFVDEDysaarvtvrlkdldsEEIKALVEEVRAFLAENFP------PDGVEVTLTGSAV 594
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 80 FDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLScLVALFLYHVVFGIQyLGILNGVAAFVIVGIG 159
Cdd:COG1033 595 LFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLP-ILLTFGLMGLLGIP-LNIATAVVASIALGIG 672
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 160 VDDVFVFINTYRQA-THLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTM 238
Cdd:COG1033 673 VDYTIHFLSRYREErRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752
|
....*..
gi 767905250 239 PAALGLW 245
Cdd:COG1033 753 PALLLLL 759
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
816-973 |
1.14e-12 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 72.20 E-value: 1.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 816 LVLSLLICVAAVAVFTTHILLLLPvllsilGIVCLVVTI------MYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYL 889
Cdd:COG1033 224 FPLALLLILLLLFLFFRSLRGVLL------PLLVVLLAViwtlglMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYR 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 890 -LAGENLPPHQAedARtqrqwrtlEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTA 968
Cdd:COG1033 298 eERRKGLDKREA--LR--------EALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPA 367
|
....*
gi 767905250 969 LLGIM 973
Cdd:COG1033 368 LLSLL 372
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
114-244 |
2.16e-12 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 65.68 E-value: 2.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 114 VFLSFFGIASIGLS--CLVALFLYhvvFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAG 191
Cdd:pfam12349 6 FGLGLAGVIIVLASvaSSLGLCAY---FGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGEVG 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 767905250 192 KATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 244
Cdd:pfam12349 83 PSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSL 135
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
41-242 |
9.55e-12 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 69.31 E-value: 9.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 41 DDRWEEQRAKFqsFVVTYVAMLAKQSTSK-VQVLYGGTDLFDYEVRRtfNNDMLLAFISSSCIAALVYILTSCSVFLSFF 119
Cdd:pfam02460 166 DEEEVEEDSKE--WEDELSQLLHNKYASEhIQFTIFHDQILNDELVR--NALTLTPFFVIGFFLLLTFSIIVSVTLSSYT 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 120 -------------GIASIGLSCLVAL-FLYhvVFGIQYLGILNgVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIH 185
Cdd:pfam02460 242 idwvrskpilaalGLLSPVMAIVSSFgLLF--WMGFPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGE 318
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 767905250 186 TVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLvTMPAAL 242
Cdd:pfam02460 319 ALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQI-TFFAAI 374
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
847-975 |
1.97e-11 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 68.35 E-value: 1.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 847 IVCLVVT--IMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLA-GENLPPHQAedartqrqwrTLEAVRHVGVAIV 923
Cdd:COG1033 640 LLPILLTfgLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREErRKGGDLEEA----------IRRALRTTGKAIL 709
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 767905250 924 SSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 975
Cdd:COG1033 710 FTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDP 761
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
70-244 |
1.31e-10 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 65.63 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 70 VQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALfLYHVVFGIQYLGILNG 149
Cdd:TIGR00921 547 VKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAI-GLMGLRGIPSFLAMAT 625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 150 VAAfVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSC 229
Cdd:TIGR00921 626 TIS-IILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLS 704
|
170
....*....|....*
gi 767905250 230 CWLAVLVTMPAALGL 244
Cdd:TIGR00921 705 SLTAALVVFPALLVL 719
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
36-244 |
6.02e-10 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 63.75 E-value: 6.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 36 NYYSVDDRWEEQRAKF------QSFVVTYVAMLAKQSTSKVQVlYGGTDLfdyevrrtfnNDMLLAFISSSCI----AAL 105
Cdd:TIGR00918 339 YYKVHHIGWNEEKAAAvleawqRNFSEEVQQSLPKNSSQKILV-FSSTTL----------DDILKKFSDVSAIrivsGYL 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 106 VYILTSCSVFL--------SFFGIASIGLSCL-VALFL-YHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATH 175
Cdd:TIGR00918 408 LMLAYACLTMLrwdcaksqGSVGLAGVLLVALsVAAGLgLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ 487
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767905250 176 LEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 244
Cdd:TIGR00918 488 NIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSL 556
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
55-244 |
1.01e-09 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 61.15 E-value: 1.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 55 VVTYVAMLAKQSTSKVQVlyGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSC-----L 129
Cdd:pfam03176 109 VRDAVEQAPPPEGLKAYL--TGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLgaaqgL 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 130 VALFLYHVVFGIQYLGIlnGVAAFVIVGIGVDDVFVFINTYRQATHL-EDPQLRMIHTVQTAGKATFFTSLTTAAAYAAN 208
Cdd:pfam03176 187 VAILAHILGIGLSTFAL--NLLVVLLIAVGTDYALFLVSRYREELRAgEDREEAVIRAVRGTGKVVTAAGLTVAIAMLAL 264
|
170 180 190
....*....|....*....|....*....|....*.
gi 767905250 209 VFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 244
Cdd:pfam03176 265 SFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
69-242 |
3.03e-09 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 61.01 E-value: 3.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 69 KVQVLYGGTDLfDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIasiglscLVALFLYHVVFGIQ-YLGI- 146
Cdd:TIGR00921 173 KFLDVTGSPAI-NYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPL-------VIILFGVAWVLGIMgWLGIp 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 147 ----LNGVAAfVIVGIGVDDVFVFINTYRQATHL-EDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGL 221
Cdd:TIGR00921 245 lyatTLLAVP-MLIGVGIDYGIQTLNRYEEERDIgRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGL 323
|
170 180
....*....|....*....|.
gi 767905250 222 FMSLIVSCCWLAVLVTMPAAL 242
Cdd:TIGR00921 324 GLVAGLITAYLLTLLVLPALL 344
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
62-244 |
1.53e-08 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 58.62 E-value: 1.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 62 LAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALflyHVVFGI 141
Cdd:COG2409 141 VAAAPAPGLTVYVTGPAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVAL---GLLALL 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 142 QYLGILNGVAAFVIV----GIGVDDVFVFINTYRQA-THLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAV 216
Cdd:COG2409 218 AAFTDVSSFAPNLLTmlglGVGIDYALFLVSRYREElRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFL 297
|
170 180
....*....|....*....|....*...
gi 767905250 217 HDFGLFMSLIVSCCWLAVLVTMPAALGL 244
Cdd:COG2409 298 RSMGPAAAIGVAVAVLAALTLLPALLAL 325
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
848-970 |
2.22e-07 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 54.84 E-value: 2.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 848 VCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYllagenlpPHQAEDARTQRQwRTLEAVRHVGVAIVSSAL 927
Cdd:TIGR00921 231 VAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRY--------EEERDIGRAKGE-AIVTAVRRTGRAVLIALL 301
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 767905250 928 TTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALL 970
Cdd:TIGR00921 302 TTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALL 344
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
78-243 |
2.86e-07 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 54.62 E-value: 2.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 78 DLFDYEVRRTFNNDMLLafISSSCIAALVYILTSCSV----FLSFFGIASIGLSCL----------VALFLYHVVFGIQY 143
Cdd:TIGR03480 675 DLNDNEALRRFVRAVRK--VAPDATGAPVSILESGDTvvgaFLQAFIYALVAITVLllltlrrvrdVLLVLAPLLLAGLL 752
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 144 LGIL-----------NGVAAFVIVGIGVDDVFVFINTYRQATHLEDPqlrmIHTvqTAGKATFFTSLTTAAAYAANVFSQ 212
Cdd:TIGR03480 753 TVAAmvllgipfnfaNIIALPLLLGLGVDFGIYMVHRWRNGVDSGNL----LQS--STARAVFFSALTTATAFGSLAVSS 826
|
170 180 190
....*....|....*....|....*....|.
gi 767905250 213 IPAVHDFGLFMSLIVSCCWLAVLVTMPAALG 243
Cdd:TIGR03480 827 HPGTASMGILLSLGLGLTLLCTLIFLPALLG 857
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
4-244 |
1.48e-06 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 52.60 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 4 PEFYWYVDEGLSADNLKSSllrSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQvlYGGTDLFDYE 83
Cdd:TIGR00917 491 PVDPTTVLGGFSGNNFSEA---SAFVVTFPVNNFVNKTNKTEKAVAWEKAFIQLAKDELLPMVQATIS--FSAERSIEDE 565
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 84 VRRTFNNDM---------LLAFISSSC--IAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVfGIQYLGILNGVAA 152
Cdd:TIGR00917 566 LKRESTADVitiaisylvMFAYISLTLgdSPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAV-GLKSTLIIMEVIP 644
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 153 FVIVGIGVDDVFVFINTY------RQATHLEDPQL-----RMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGL 221
Cdd:TIGR00917 645 FLVLAVGVDNIFILVFFYfyleyfYRQVGVDNEQEltlerRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSM 724
|
250 260
....*....|....*....|...
gi 767905250 222 FMSLIVSCCWLAVLVTMPAALGL 244
Cdd:TIGR00917 725 FAVLAVFLDFLLQITAFVALLVL 747
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
63-241 |
1.91e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 52.16 E-value: 1.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 63 AKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGiq 142
Cdd:COG4258 222 LNAAFPGAQLLLTGAGLFAVAAAQQIKHDISTIGLISLLGILLLLLLVFRSLRPLLLGLLPVAVGALAGLAAVSLVFG-- 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 143 YLGILNGVAAFVIVGIGVDDVFVFInTYRQATHLEDPQlrmiHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLF 222
Cdd:COG4258 300 SVHGITLGFGSSLIGVAVDYSLHYL-THRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLFSPFPGLRQLGVF 374
|
170 180
....*....|....*....|....*
gi 767905250 223 --MSLIVSC----CWLAVLVTMPAA 241
Cdd:COG4258 375 aaAGLLAAAlttlLWLPLLLPRAAP 399
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
846-970 |
2.36e-06 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 51.76 E-value: 2.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 846 GIVCLVVTIMyWSGWEMGA-------VEAISLSILVGSSVDYCVHLVEGYLlagENLPPHQAEDArtqrqWRTleAVRHV 918
Cdd:TIGR00921 597 PLIAIGSGIL-WAIGLMGLrgipsflAMATTISIILGLGMDYSIHLAERYF---EERKEHGPKEA-----ITH--TMERT 665
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 767905250 919 GVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALL 970
Cdd:TIGR00921 666 GPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALL 717
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
868-985 |
4.64e-06 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 50.74 E-value: 4.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 868 ISLSILVGSSVDYCVHLVEGYLlagENLPPHQAEDARTQrqwrtlEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKF 947
Cdd:TIGR00833 236 LLTALVIGAGTDYAVFLTGRYH---EERRKGESLEEAAA------EALRGTGKAILGSALTVAVAFLALSLARLPSFKTL 306
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 767905250 948 GKIVALNTGVSILYTLTVSTALL------GIMAPSSFTRTRTSF 985
Cdd:TIGR00833 307 GVSCAVGVLVALLNAVTLTPALLtlegreGLMKPGRKSKIRFIW 350
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
853-973 |
9.40e-05 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 46.52 E-value: 9.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 853 TIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEgyllageNLPPHQAEDARTQRQwRTLEAVRHVGVAIVSSALTTVIA 932
Cdd:pfam00873 374 AVMKAFGFSINTLTLGGLVLAIGLVVDDAIVVVE-------NIERVLEENGLKPLE-AAYKSMGEIGGALVAIALVLSAV 445
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 767905250 933 TVPLFF---CIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIM 973
Cdd:pfam00873 446 FLPILFlggLTGRIFRQFAITIVLAILLSVLVALTLTPALCATL 489
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
847-976 |
5.16e-04 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 44.22 E-value: 5.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 847 IVCLVVTiMYWSGWEMGAVEAISLS---ILVGSSVDYCVHLVEGY---LLAGENLPphQAedartqrqwrTLEAVRHVGV 920
Cdd:TIGR03480 304 IVGLILT-AAFATLAVGHLNLISVAfavLFIGLGVDFAIQFSLRYreeRFRGGNHR--EA----------LSVAARRMGA 370
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 921 AIVSSALTTVIAtvplFFCII----APFAKFGKIVALNTGVSILYTLTVSTALLGIMAPS 976
Cdd:TIGR03480 371 ALLLAALATAAG----FFAFLptdyKGVSELGIIAGTGMFIALFVTLTVLPALLRLLRPP 426
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
103-240 |
5.86e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 43.69 E-value: 5.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 103 AALVYILTSCSVFLSFFGI-------ASIGLSCLVALFLYhVVFGIQyLGILNGVAAFVIVGIGVD-DVFVfintyRQAT 174
Cdd:COG4258 645 LLLALLLILLLLLLRLRSLrralrvlLPPLLAVLLTLAIL-GLLGIP-LNLFHLIALLLVLGIGIDyALFF-----TEGL 717
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767905250 175 HLEDPQLRMIHTVqtagkatFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPA 240
Cdd:COG4258 718 LDKGELARTLLSI-------LLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLLAPLLAPR 776
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
809-975 |
7.59e-04 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 43.50 E-value: 7.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 809 VQSALCGLVLSLLICVAAVA-VFTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEG 887
Cdd:pfam02460 637 ILPSTIQNIVITLICMFIVCfLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYH 716
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 888 YLLAGENLPphqaedarTQRQWRTLEAvrhVGVAIVSSALTTVIATVPLFFC---IIAPFAkfgKIVALNTGVSILYTLT 964
Cdd:pfam02460 717 FVRSRGDTP--------AERVVDALEA---LGWPVFQGGLSTILGVLVLLFVpsyMVVVFF---KTVFLVVAIGLLHGLF 782
|
170
....*....|.
gi 767905250 965 VSTALLGIMAP 975
Cdd:pfam02460 783 ILPIILSLFVT 793
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
66-245 |
1.33e-03 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 42.68 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 66 STSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTscsvFLSFFGIASIgLSCLVALFLYHVVFGIQYLG 145
Cdd:TIGR03480 245 EDHGVTVRLTGEVALSDEELATVSEGATVAGLLSFVLVLVLLWLA----LRSPRLVFAV-LVTLIVGLILTAAFATLAVG 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 146 ILNGVA-AFVI--VGIGVDDVFVFINTYRQATHLEDPQLRMIH-TVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGL 221
Cdd:TIGR03480 320 HLNLISvAFAVlfIGLGVDFAIQFSLRYREERFRGGNHREALSvAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGI 399
|
170 180
....*....|....*....|....
gi 767905250 222 FMSLIVSCCWLAVLVTMPAALGLW 245
Cdd:TIGR03480 400 IAGTGMFIALFVTLTVLPALLRLL 423
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
867-982 |
2.33e-03 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 41.51 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 867 AISLSILVGSSVDYCVHLVEGYllagenlppHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAK 946
Cdd:pfam03176 204 NLLVVLLIAVGTDYALFLVSRY---------REELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQ 274
|
90 100 110
....*....|....*....|....*....|....*.
gi 767905250 947 FGKIVALNTGVSILYTLTVSTALLGIMAPSSFTRTR 982
Cdd:pfam03176 275 VGPTIAIGVLVDVLAALTLLPALLALLGRWGLWPPK 310
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
868-972 |
2.70e-03 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 41.67 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 868 ISLSILVGSSVDYCVHLVEGY---LLAGENlpPHQAedARTqrqwrtleAVRHVGVAIVSSALTTVIATVPLFFCIIAPF 944
Cdd:COG2409 230 LLTMLGLGVGIDYALFLVSRYreeLRAGED--REEA--VAR--------AVATAGRAVLFSGLTVAIALLGLLLAGLPFL 297
|
90 100
....*....|....*....|....*...
gi 767905250 945 AKFGKIVALNTGVSILYTLTVSTALLGI 972
Cdd:COG2409 298 RSMGPAAAIGVAVAVLAALTLLPALLAL 325
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
88-246 |
7.76e-03 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 40.34 E-value: 7.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 88 FNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALflyHVVFGIQYLGILnGVAAF-------VIVGIGV 160
Cdd:TIGR00833 171 GDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQ---GIVSLLGIPGLI-GVNAQttvlltaLVIGAGT 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905250 161 DDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMP 239
Cdd:TIGR00833 247 DYAVFLTGRYHEERrKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTP 326
|
....*..
gi 767905250 240 AALGLWS 246
Cdd:TIGR00833 327 ALLTLEG 333
|
|
| |
