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Conserved domains on  [gi|767903599|ref|XP_011539487|]
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transmembrane and coiled-coil domain-containing protein 4 isoform X5 [Homo sapiens]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
185-521 6.86e-157

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member pfam05277:

Pssm-ID: 473884  Cd Length: 341  Bit Score: 454.54  E-value: 6.86e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  185 RKWKRYLLIGLATVGGGTVIGVTGGLA----APLVAAGAATIIGSAGAAALGSAAGIAIMTSLFGAAGAGLTGYKMKKRV 260
Cdd:pfam05277   1 RRIKRYILIGLAGLGGGALIGLTGGLAaplvAAGIGALFGGFGLGGSAGFLASTGGSAVITALFGAAGAGLTGYKMSKRV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  261 GAIEEFTFLPLTEGRQLHITIAVTGWLASGKYRTFSAPWAALAHSR-EQYCLAWEAKYLMELGNALETIL-SGLANMVAQ 338
Cdd:pfam05277  81 GAIKTFEFIPLSGNRSLSLTVTVSGWGELGDEDDVTNPWRALDPNCgDLYALKWEVEYLKELGNALETILaSEAFSMAKQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  339 EALKYTVLSGIVAALTWPASLLSVANVIDNPWGVCLHRSAEVGKHLAHILLSRQQGRRPVTLIGFSLGARVIYFCLQEMA 418
Cdd:pfam05277 161 EILGRTVLTSLVAALTWPLALLKVGSILDNPWNVCLDRAAKAGEILADALCSRAHGQRPVTLIGFSLGARVIFYCLLELA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  419 QeKDCQGIIEDVILLGAPVEGEAKHWEPFRKVVSGRIINGYCRGDWLLSFVYRTSSVQLRVAGLQPVLLQDrRVENVDLT 498
Cdd:pfam05277 241 K-RKAFGIIENVILMGTPATTSAKVWEKMRSVVSGRFVNGYSENDWLLGFLYRTMSAQFRVAGLGPIENVP-GIENVDVS 318
                         330       340
                  ....*....|....*....|...
gi 767903599  499 SVVSGHLDYAKQMDAILKAVGIR 521
Cdd:pfam05277 319 GIVSGHLDYRKLMPKILKAIGFE 341
 
Name Accession Description Interval E-value
DUF726 pfam05277
Protein of unknown function (DUF726); This family consists of several uncharacterized ...
185-521 6.86e-157

Protein of unknown function (DUF726); This family consists of several uncharacterized eukaryotic proteins.


Pssm-ID: 368366  Cd Length: 341  Bit Score: 454.54  E-value: 6.86e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  185 RKWKRYLLIGLATVGGGTVIGVTGGLA----APLVAAGAATIIGSAGAAALGSAAGIAIMTSLFGAAGAGLTGYKMKKRV 260
Cdd:pfam05277   1 RRIKRYILIGLAGLGGGALIGLTGGLAaplvAAGIGALFGGFGLGGSAGFLASTGGSAVITALFGAAGAGLTGYKMSKRV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  261 GAIEEFTFLPLTEGRQLHITIAVTGWLASGKYRTFSAPWAALAHSR-EQYCLAWEAKYLMELGNALETIL-SGLANMVAQ 338
Cdd:pfam05277  81 GAIKTFEFIPLSGNRSLSLTVTVSGWGELGDEDDVTNPWRALDPNCgDLYALKWEVEYLKELGNALETILaSEAFSMAKQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  339 EALKYTVLSGIVAALTWPASLLSVANVIDNPWGVCLHRSAEVGKHLAHILLSRQQGRRPVTLIGFSLGARVIYFCLQEMA 418
Cdd:pfam05277 161 EILGRTVLTSLVAALTWPLALLKVGSILDNPWNVCLDRAAKAGEILADALCSRAHGQRPVTLIGFSLGARVIFYCLLELA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  419 QeKDCQGIIEDVILLGAPVEGEAKHWEPFRKVVSGRIINGYCRGDWLLSFVYRTSSVQLRVAGLQPVLLQDrRVENVDLT 498
Cdd:pfam05277 241 K-RKAFGIIENVILMGTPATTSAKVWEKMRSVVSGRFVNGYSENDWLLGFLYRTMSAQFRVAGLGPIENVP-GIENVDVS 318
                         330       340
                  ....*....|....*....|...
gi 767903599  499 SVVSGHLDYAKQMDAILKAVGIR 521
Cdd:pfam05277 319 GIVSGHLDYRKLMPKILKAIGFE 341
 
Name Accession Description Interval E-value
DUF726 pfam05277
Protein of unknown function (DUF726); This family consists of several uncharacterized ...
185-521 6.86e-157

Protein of unknown function (DUF726); This family consists of several uncharacterized eukaryotic proteins.


Pssm-ID: 368366  Cd Length: 341  Bit Score: 454.54  E-value: 6.86e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  185 RKWKRYLLIGLATVGGGTVIGVTGGLA----APLVAAGAATIIGSAGAAALGSAAGIAIMTSLFGAAGAGLTGYKMKKRV 260
Cdd:pfam05277   1 RRIKRYILIGLAGLGGGALIGLTGGLAaplvAAGIGALFGGFGLGGSAGFLASTGGSAVITALFGAAGAGLTGYKMSKRV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  261 GAIEEFTFLPLTEGRQLHITIAVTGWLASGKYRTFSAPWAALAHSR-EQYCLAWEAKYLMELGNALETIL-SGLANMVAQ 338
Cdd:pfam05277  81 GAIKTFEFIPLSGNRSLSLTVTVSGWGELGDEDDVTNPWRALDPNCgDLYALKWEVEYLKELGNALETILaSEAFSMAKQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  339 EALKYTVLSGIVAALTWPASLLSVANVIDNPWGVCLHRSAEVGKHLAHILLSRQQGRRPVTLIGFSLGARVIYFCLQEMA 418
Cdd:pfam05277 161 EILGRTVLTSLVAALTWPLALLKVGSILDNPWNVCLDRAAKAGEILADALCSRAHGQRPVTLIGFSLGARVIFYCLLELA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  419 QeKDCQGIIEDVILLGAPVEGEAKHWEPFRKVVSGRIINGYCRGDWLLSFVYRTSSVQLRVAGLQPVLLQDrRVENVDLT 498
Cdd:pfam05277 241 K-RKAFGIIENVILMGTPATTSAKVWEKMRSVVSGRFVNGYSENDWLLGFLYRTMSAQFRVAGLGPIENVP-GIENVDVS 318
                         330       340
                  ....*....|....*....|...
gi 767903599  499 SVVSGHLDYAKQMDAILKAVGIR 521
Cdd:pfam05277 319 GIVSGHLDYRKLMPKILKAIGFE 341
DUF900 pfam05990
Alpha/beta hydrolase of unknown function (DUF900); This family consists of several ...
353-508 2.15e-03

Alpha/beta hydrolase of unknown function (DUF900); This family consists of several hypothetical proteins of unknown function mostly found in Rhizobium species. Members of this family have an alpha/beta hydrolase fold.


Pssm-ID: 399172  Cd Length: 236  Bit Score: 40.11  E-value: 2.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  353 LTWPASLLSVANVIDNpwgvclhRSAEVGK-HLAHIL--LSRQQGRRPVTLIGFSLGARVIYFCLQEMAQEKDCQGI--- 426
Cdd:pfam05990  55 FTWPSRGSVFDYNYDK-------ESANYSRpALEHLLryLANDPPVKKIYLIAHSMGTWLVMEALRQLAIEADEPGVeak 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767903599  427 IEDVILLgAP----------VEGEAKHWEPFRKVVSgriingycRGDWLLSFVYRTSSVQLRVAGLQPVLLQDRR----- 491
Cdd:pfam05990 128 IDNVILA-APdidvdvfrkqIASLGKESPRFTLFVS--------RDDRALKASRRLSGDASRLGQIDPSVEPYRSellka 198
                         170       180
                  ....*....|....*....|..
gi 767903599  492 -VENVDLTSVVS----GHLDYA 508
Cdd:pfam05990 199 gITVVDLTKLKAsdllNHSYFA 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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