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Conserved domains on  [gi|767902747|ref|XP_011539147|]
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KN motif and ankyrin repeat domain-containing protein 4 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
817-964 3.45e-30

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 121.21  E-value: 3.45e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 817 VNLADHNGNTALHYSVSHSNFSIVKLLLEtetnedmavvwkllREGNVNIQaTQGGQTALMLGVSHDREDMVQALLSCQA 896
Cdd:COG0666  113 VNARDKDGETPLHLAAYNGNLEIVKLLLE--------------AGADVNAQ-DNDGNTPLHLAAANGNLEIVKLLLEAGA 177

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902747 897 DVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSPtHMEIAGLLRAHAE 964
Cdd:COG0666  178 DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENG-NLEIVKLLLEAGA 243
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 24-62 3.62e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


:

Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.32  E-value: 3.62e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767902747   24 PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAK 62
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
341-411 5.47e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


:

Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.35  E-value: 5.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767902747 341 SISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIREL--EFTVAQLEGQFHQENAKDTQGQTD 411
Cdd:COG4372   39 ELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELneQLQAAQAELAQAQEELESLQEEAE 111
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
817-964 3.45e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 121.21  E-value: 3.45e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 817 VNLADHNGNTALHYSVSHSNFSIVKLLLEtetnedmavvwkllREGNVNIQaTQGGQTALMLGVSHDREDMVQALLSCQA 896
Cdd:COG0666  113 VNARDKDGETPLHLAAYNGNLEIVKLLLE--------------AGADVNAQ-DNDGNTPLHLAAANGNLEIVKLLLEAGA 177

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902747 897 DVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSPtHMEIAGLLRAHAE 964
Cdd:COG0666  178 DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENG-NLEIVKLLLEAGA 243
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 24-62 3.62e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.32  E-value: 3.62e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767902747   24 PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAK 62
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
876-962 1.03e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.23  E-value: 1.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747  876 LMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSsltDKAGRTALSIALKSpTHMEI 955
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL---KDNGRTALHYAARS-GHLEI 76


                  ....*..
gi 767902747  956 AGLLRAH 962
Cdd:pfam12796  77 VKLLLEK 83
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 817-963 4.02e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.98  E-value: 4.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 817 VNLADHNGNTALHYSVSHSNFSIVKLLLET----ETNE--------------DMAVVWKLLREGNVNIQATQGGQTALML 878
Cdd:PHA02874 150 VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKgayaNVKDnngesplhnaaeygDYACIKLLIDHGNHIMNKCKNGFTPLHN 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 879 GVSHDREdmVQALLSCQADVNLQDHDGSSALmvacHHG-----NVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSPTHM 953
Cdd:PHA02874 230 AIIHNRS--AIELLINNASINDQDIDGSTPL----HHAinppcDIDIIDILLYHKA-DISIKDNKGENPIDTAFKYINKD 302

                        170
                 ....*....|
gi 767902747 954 EIAGLLRAHA 963
Cdd:PHA02874 303 PVIKDIIANA 312
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
341-411 5.47e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.35  E-value: 5.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767902747 341 SISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIREL--EFTVAQLEGQFHQENAKDTQGQTD 411
Cdd:COG4372   39 ELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELneQLQAAQAELAQAQEELESLQEEAE 111
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 335-395 5.56e-04

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 41.84  E-value: 5.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902747  335 ARVDPGSISSLKQQVSALEGELSG----RTEELAQVRTA---LQQQEEEIKAREQRIRELEFTVAQLE 395
Cdd:pfam08614  45 ASPQSASIQSLEQLLAQLREELAElyrsRGELAQRLVDLneeLQELEKKLREDERRLAALEAERAQLE 112
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 904-927 2.45e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 2.45e-03
                           10        20
                   ....*....|....*....|....
gi 767902747   904 DGSSALMVACHHGNVDLVRLLLAH 927
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDK 24
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
817-964 3.45e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 121.21  E-value: 3.45e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 817 VNLADHNGNTALHYSVSHSNFSIVKLLLEtetnedmavvwkllREGNVNIQaTQGGQTALMLGVSHDREDMVQALLSCQA 896
Cdd:COG0666  113 VNARDKDGETPLHLAAYNGNLEIVKLLLE--------------AGADVNAQ-DNDGNTPLHLAAANGNLEIVKLLLEAGA 177

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902747 897 DVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSPtHMEIAGLLRAHAE 964
Cdd:COG0666  178 DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENG-NLEIVKLLLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
813-962 5.46e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.27  E-value: 5.46e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 813 LKLLVNLADHNGNTALHYSVSHSNFSIVKLLLEtetnedmavvwkllREGNVNIQaTQGGQTALMLGVSHDREDMVQALL 892
Cdd:COG0666   76 AGADINAKDDGGNTLLHAAARNGDLEIVKLLLE--------------AGADVNAR-DKDGETPLHLAAYNGNLEIVKLLL 140

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 893 SCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSPtHMEIAGLLRAH 962
Cdd:COG0666  141 EAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENG-HLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
817-964 1.19e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 99.26  E-value: 1.19e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 817 VNLADHNGNTALHYSVSHSNFSIVKLLLEtetnedmavvwkllREGNVNIQaTQGGQTALMLGVSHDREDMVQALLSCQA 896
Cdd:COG0666  146 VNAQDNDGNTPLHLAAANGNLEIVKLLLE--------------AGADVNAR-DNDGETPLHLAAENGHLEIVKLLLEAGA 210

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902747 897 DVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAE 964
Cdd:COG0666  211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLL 277
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 24-62 3.62e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.32  E-value: 3.62e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767902747   24 PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAK 62
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
842-962 1.93e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 90.01  E-value: 1.93e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 842 LLLETETNEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLV 921
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767902747 922 RLLLAHPAcDSSLTDKAGRTALSIALKSPtHMEIAGLLRAH 962
Cdd:COG0666  137 KLLLEAGA-DVNAQDNDGNTPLHLAAANG-NLEIVKLLLEA 175
Ank_2 pfam12796
Ankyrin repeats (3 copies);
876-962 1.03e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.23  E-value: 1.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747  876 LMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSsltDKAGRTALSIALKSpTHMEI 955
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL---KDNGRTALHYAARS-GHLEI 76


                  ....*..
gi 767902747  956 AGLLRAH 962
Cdd:pfam12796  77 VKLLLEK 83
Ank_2 pfam12796
Ankyrin repeats (3 copies);
828-929 1.29e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 1.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747  828 LHYSVSHSNFSIVKLLLETETNEDMAvvwkllregnvniqaTQGGQTALMLGVSHDREDMVQALLScQADVNLQDHdGSS 907
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ---------------DKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRT 63

                          90       100
                  ....*....|....*....|..
gi 767902747  908 ALMVACHHGNVDLVRLLLAHPA 929
Cdd:pfam12796  64 ALHYAARSGHLEIVKLLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
809-902 1.93e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 1.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747  809 SPHFLKLLV------NLADHNGNTALHYSVSHSNFSIVKLLLEtetnedmavvwkllregNVNIQATQGGQTALMLGVSH 882
Cdd:pfam12796   9 NLELVKLLLengadaNLQDKNGRTALHLAAKNGHLEIVKLLLE-----------------HADVNLKDNGRTALHYAARS 71

                          90       100
                  ....*....|....*....|
gi 767902747  883 DREDMVQALLSCQADVNLQD 902
Cdd:pfam12796  72 GHLEIVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
834-962 4.66e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 4.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 834 HSNFSIVKLLLETETNEDMAVVWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVAC 913
Cdd:COG0666   16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAA 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767902747 914 HHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSPtHMEIAGLLRAH 962
Cdd:COG0666   96 RNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYNG-NLEIVKLLLEA 142
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 817-963 4.02e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.98  E-value: 4.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 817 VNLADHNGNTALHYSVSHSNFSIVKLLLET----ETNE--------------DMAVVWKLLREGNVNIQATQGGQTALML 878
Cdd:PHA02874 150 VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKgayaNVKDnngesplhnaaeygDYACIKLLIDHGNHIMNKCKNGFTPLHN 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 879 GVSHDREdmVQALLSCQADVNLQDHDGSSALmvacHHG-----NVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSPTHM 953
Cdd:PHA02874 230 AIIHNRS--AIELLINNASINDQDIDGSTPL----HHAinppcDIDIIDILLYHKA-DISIKDNKGENPIDTAFKYINKD 302

                        170
                 ....*....|
gi 767902747 954 EIAGLLRAHA 963
Cdd:PHA02874 303 PVIKDIIANA 312
Ank_5 pfam13857
Ankyrin repeats (many copies);
891-946 5.20e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 53.12  E-value: 5.20e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767902747  891 LLSC-QADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPaCDSSLTDKAGRTALSIA 946
Cdd:pfam13857   1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 888-970 4.03e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.22  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 888 VQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSPTHmEIAGLLRAHAEQGR 967
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGA-DPTLLDKDGKTPLELAEENGFR-EVVQLLSRHSQCHF 175


                 ...
gi 767902747 968 SLG 970
Cdd:PTZ00322 176 ELG 178
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 817-950 4.06e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.81  E-value: 4.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 817 VNLAD-HNGNTALHYSVSHSNFSIVKLLLetetnedmavvwklLREGNVNIqATQGGQTALMLGVSHDREDMVQALLSCQ 895
Cdd:PHA02878 160 INMKDrHKGNTALHYATENKDQRLTELLL--------------SYGANVNI-PDKTNNSPLHHAVKHYNKPIVHILLENG 224

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767902747 896 ADVNLQDHDGSSALMVACHH-GNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSP 950
Cdd:PHA02878 225 ASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILGLTALHSSIKSE 280
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 809-927 1.22e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.06  E-value: 1.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 809 SPHFLKLL------VNLADHNGNTALHYSVS--HSNFSIVKLLLETETNEDMAVVWKLLREGNVNIQATQG-GQTALMLG 879
Cdd:PHA03100 120 SYSIVEYLldnganVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGVDINAKNRVNYLLSYGVPINIKDVyGFTPLHYA 199

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 767902747 880 VSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAH 927
Cdd:PHA03100 200 VYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNN 247
Ank_4 pfam13637
Ankyrin repeats (many copies);
874-925 1.44e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 1.44e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767902747  874 TALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLL 925
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 844-959 9.69e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.33  E-value: 9.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 844 LETETNEDMAVVWKLLREG-NVNiQATQGGQTAL---MLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNV- 918
Cdd:PHA03095  19 LLNASNVTVEEVRRLLAAGaDVN-FRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTl 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767902747 919 DLVRLLLAHPAcDSSLTDKAGRTALSIALKSP-THMEIAGLL 959
Cdd:PHA03095  98 DVIKLLIKAGA-DVNAKDKVGRTPLHVYLSGFnINPKVIRLL 138
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 817-929 4.37e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.56  E-value: 4.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETETNEDmavvwkllregnvniqaTQGGQTALMLGVSHDREDMVQALLSCQA 896
Cdd:PLN03192 584 VHIRDANGNTALWNAISAKHHKIFRILYHFASISD-----------------PHAAGDLLCTAAKRNDLTAMKELLKQGL 646

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767902747 897 DVNLQDHDGSSALMVACHHGNVDLVRLLLAHPA 929
Cdd:PLN03192 647 NVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
Ank_4 pfam13637
Ankyrin repeats (many copies);
905-959 4.57e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.88  E-value: 4.57e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767902747  905 GSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSpTHMEIAGLL 959
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASN-GNVEVLKLL 53
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 817-930 1.09e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.03  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETETNED-----------MAV-------VWKLLRE--GNVNIQATQGGQTAL 876
Cdd:PHA02878 194 VNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDardkcgntplhISVgyckdydILKLLLEhgVDVNAKSYILGLTAL 273

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767902747 877 MLGVsHDrEDMVQALLSCQADVNLQDHDGSSAL-MVACHHGNVDLVRLLLAHPAC 930
Cdd:PHA02878 274 HSSI-KS-ERKLKLLLEYGADINSLNSYKLTPLsSAVKQYLCINIGRILISNICL 326
Ank_5 pfam13857
Ankyrin repeats (many copies);
858-912 1.28e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 1.28e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767902747  858 LLREGNVNIQATQG-GQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVA 912
Cdd:pfam13857   1 LLEHGPIDLNRLDGeGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 817-950 1.50e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 817 VNLADHNGNTALHYSVSHSN-FSIVKLLLETETNedmavvwklLREGNVNiqatqgGQTAL--MLGVSHDREDMVQALLS 893
Cdd:PHA03095  76 VNAPERCGFTPLHLYLYNATtLDVIKLLIKAGAD---------VNAKDKV------GRTPLhvYLSGFNINPKVIRLLLR 140

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767902747 894 CQADVNLQDHDGSSAL--MVACHHGNVDLVRLLLAHpACDSSLTDKAGRTALSIALKSP 950
Cdd:PHA03095 141 KGADVNALDLYGMTPLavLLKSRNANVELLRLLIDA-GADVYAVDDRFRSLLHHHLQSF 198
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 818-947 2.48e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.60  E-value: 2.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 818 NLADHNGNTALHYSVSHSNFSIVKLLL-------------ETETNE-----DMAVVWKLLREGN-VNIQATQGGQTALML 878
Cdd:PHA02875  29 NFEIYDGISPIKLAMKFRDSEAIKLLMkhgaipdvkypdiESELHDaveegDVKAVEELLDLGKfADDVFYKDGMTPLHL 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767902747 879 GVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACdSSLTDKAGRTALSIAL 947
Cdd:PHA02875 109 ATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKAC-LDIEDCCGCTPLIIAM 176
Ank_4 pfam13637
Ankyrin repeats (many copies);
817-844 2.84e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 2.84e-04
                          10        20
                  ....*....|....*....|....*...
gi 767902747  817 VNLADHNGNTALHYSVSHSNFSIVKLLL 844
Cdd:pfam13637  27 INAVDGNGETALHFAASNGNVEVLKLLL 54
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
341-411 5.47e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.35  E-value: 5.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767902747 341 SISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIREL--EFTVAQLEGQFHQENAKDTQGQTD 411
Cdd:COG4372   39 ELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELneQLQAAQAELAQAQEELESLQEEAE 111
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 335-395 5.56e-04

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 41.84  E-value: 5.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902747  335 ARVDPGSISSLKQQVSALEGELSG----RTEELAQVRTA---LQQQEEEIKAREQRIRELEFTVAQLE 395
Cdd:pfam08614  45 ASPQSASIQSLEQLLAQLREELAElyrsRGELAQRLVDLneeLQELEKKLREDERRLAALEAERAQLE 112
PHA02741 PHA02741
hypothetical protein; Provisional
 809-946 9.01e-04

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 41.18  E-value: 9.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 809 SPHFLKLLVN-LADHN--GNTALHYSVSHSNFSIVKLLLETETNEDMAVvwkLLREGNVniqatQGGQTALMLGVSHDRE 885
Cdd:PHA02741   3 SPHFMTCLEEmIAEKNseGENFFHEAARCGCFDIIARFTPFIRGDCHAA---ALNATDD-----AGQMCIHIAAEKHEAQ 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767902747 886 ---DMVQALLSCQADVNLQDH-DGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIA 946
Cdd:PHA02741  75 laaEIIDHLIELGADINAQEMlEGDTALHLAAHRRDHDLAEWLCCQPGIDLHFCNADNKSPFELA 139
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 817-927 9.80e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.64  E-value: 9.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETetnedmavvwkllrEGNVNIQATQgGQTALMLGVSHDREDMVQALLSCQA 896
Cdd:PHA02874 117 VNIKDAELKTFLHYAIKKGDLESIKMLFEY--------------GADVNIEDDN-GCYPIHIAIKHNFFDIIKLLLEKGA 181

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767902747 897 DVNLQDHDGSSALMVACHHGNVDLVRLLLAH 927
Cdd:PHA02874 182 YANVKDNNGESPLHNAAEYGDYACIKLLIDH 212
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 872-934 1.29e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 1.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767902747 872 GQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSL 934
Cdd:PTZ00322 115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
ZapB pfam06005
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ...
 342-387 1.35e-03

Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.


Pssm-ID: 428718 [Multi-domain]  Cd Length: 71  Bit Score: 38.02  E-value: 1.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767902747  342 ISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIREL 387
Cdd:pfam06005  20 IALLQMENEELKEENEELKEEANELEEENQQLKQERNQWQERIRGL 65
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 872-903 1.82e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 1.82e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767902747  872 GQTALMLGVSH-DREDMVQALLSCQADVNLQDH 903
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 342-405 2.09e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 2.09e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767902747 342 ISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQfhQENAKD 405
Cdd:COG1579   26 LKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ--LGNVRN 87
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
342-412 2.22e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.43  E-value: 2.22e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767902747 342 ISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDV 412
Cdd:COG4372   47 LEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEEL 117
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 817-948 2.43e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.40  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETETNEDMAVVWKLLREG----NVNI------QATQGGQTALMLGV-SHDRE 885
Cdd:PHA02878  63 VNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAfnnrNVEIfkiiltNRYKNIQTIDLVYIdKKSKD 142

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767902747 886 DMVQA-----LLSCQADVNLQD-HDGSSALMVACHHGNVDLVRLLLAHPACDSSLtDKAGRTALSIALK 948
Cdd:PHA02878 143 DIIEAeitklLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIP-DKTNNSPLHHAVK 210
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 904-927 2.45e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 2.45e-03
                           10        20
                   ....*....|....*....|....
gi 767902747   904 DGSSALMVACHHGNVDLVRLLLAH 927
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDK 24
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 904-929 2.46e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 2.46e-03
                          10        20
                  ....*....|....*....|....*.
gi 767902747  904 DGSSALMVACHHGNVDLVRLLLAHPA 929
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGA 26
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 342-400 3.23e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 3.23e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767902747 342 ISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQ 400
Cdd:COG4942   43 LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
342-414 4.29e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.66  E-value: 4.29e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767902747 342 ISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMV 414
Cdd:COG4372  117 LEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELL 189
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 342-397 4.93e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 4.93e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767902747 342 ISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQ 397
Cdd:COG4942   29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAE 84
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 872-899 5.19e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 5.19e-03
                          10        20
                  ....*....|....*....|....*...
gi 767902747  872 GQTALMLGVSHDREDMVQALLSCQADVN 899
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 317-388 5.96e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.52  E-value: 5.96e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767902747 317 EVDMRSIGIRVTEESLglarvdPGSISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELE 388
Cdd:COG1579   14 ELDSELDRLEHRLKEL------PAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYE 79
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 812-899 6.43e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.03  E-value: 6.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 812 FLKLLV--NLADHNGNTALHYSVSHSNFSIVKLLLEtetnedmavvwkllrEG-NVNIqATQGGQTALMLGVSHDREDMV 888
Cdd:PHA03100 178 LLSYGVpiNIKDVYGFTPLHYAVYNNNPEFVKYLLD---------------LGaNPNL-VNKYGDTPLHIAILNNNKEIF 241

                         90
                 ....*....|.
gi 767902747 889 QALLSCQADVN 899
Cdd:PHA03100 242 KLLLNNGPSIK 252
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 857-962 6.87e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.25  E-value: 6.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747 857 KLLRE--GNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSL 934
Cdd:PHA02878 151 KLLLSygADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA-STDA 229

                         90       100
                 ....*....|....*....|....*...
gi 767902747 935 TDKAGRTALSIALKSPTHMEIAGLLRAH 962
Cdd:PHA02878 230 RDKCGNTPLHISVGYCKDYDILKLLLEH 257
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
317-409 7.42e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.28  E-value: 7.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902747  317 EVDMRSI--GIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELE------ 388
Cdd:COG4913   660 EIDVASAerEIAELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQdrleaa 739

                          90       100
                  ....*....|....*....|....*..
gi 767902747  389 ------FTVAQLEGQFHQENAKDTQGQ 409
Cdd:COG4913   740 edlarlELRALLEERFAAALGDAVERE 766
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 823-845 7.53e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 7.53e-03
                           10        20
                   ....*....|....*....|...
gi 767902747   823 NGNTALHYSVSHSNFSIVKLLLE 845
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLD 23
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
341-409 8.28e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.50  E-value: 8.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767902747 341 SISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQ 409
Cdd:COG4372   32 QLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQ 100
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 325-388 9.40e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 39.63  E-value: 9.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767902747  325 IRVTEESLGLARVDPgsISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELE 388
Cdd:pfam05667 322 KVETEEELQQQREEE--LEELQEQLEDLESSIQELEKEIKKLESSIKQVEEELEELKEQNEELE 383
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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