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Conserved domains on  [gi|767964149|ref|XP_011538605|]
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outer mitochondrial transmembrane helix translocase isoform X3 [Homo sapiens]

Protein Classification

ATP-binding protein( domain architecture ID 15329613)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to vacuolar protein sorting 4 AAA-ATPase (Vps4), which recycles endosomal sorting complexes required for transport (ESCRT-III) polymers from cellular membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 92-257 4.04e-121

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 343.64  E-value: 4.04e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  92 DIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQ 171
Cdd:cd19520    1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 172 KLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRM 251
Cdd:cd19520   81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160


                 ....*.
gi 767964149 252 PTRFHI 257
Cdd:cd19520  161 PKRFHI 166
 
Name Accession Description Interval E-value
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 92-257 4.04e-121

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 343.64  E-value: 4.04e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  92 DIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQ 171
Cdd:cd19520    1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 172 KLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRM 251
Cdd:cd19520   81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160


                 ....*.
gi 767964149 252 PTRFHI 257
Cdd:cd19520  161 PKRFHI 166
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 88-279 3.26e-67

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 212.56  E-value: 3.26e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWY 167
Cdd:COG1222   75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGI-EPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYI 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 168 GESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSS-DHEATAMMKAQFMSLWDGLDTDHScqVIVMGATNRPQDLDSA 246
Cdd:COG1222  154 GEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDgTSGEVQRTVNQLLAELDGFESRGD--VLIIAATNRPDLLDPA 231

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 767964149 247 IMRrmPTRF----HINQPALKQREAILKLILKNENDS 279
Cdd:COG1222  232 LLR--PGRFdrviEVPLPDEEAREEILKIHLRDMPLA 266
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 88-270 1.79e-49

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 168.47  E-value: 1.79e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWY 167
Cdd:PRK03992 128 VTYEDIGGLEEQIREVREAVELPLKKPELFEEVGI-EPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 168 GESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNR----SSSDHEA--TaMMkaQFMSLWDGLDTdhSCQVIVMGATNRPQ 241
Cdd:PRK03992 207 GEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdsgTSGDREVqrT-LM--QLLAEMDGFDP--RGNVKIIAATNRID 281

                        170       180       190
                 ....*....|....*....|....*....|...
gi 767964149 242 DLDSAIMRrmPTRF----HINQPALKQREAILK 270
Cdd:PRK03992 282 ILDPAILR--PGRFdriiEVPLPDEEGRLEILK 312
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 129-257 1.93e-47

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 155.06  E-value: 1.93e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  129 VLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEA 208
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 767964149  209 TAMMKAQFMSLWDGLDTDHScQVIVMGATNRPQDLDSAIMRRMPTRFHI 257
Cdd:pfam00004  81 SRRVVNQLLTELDGFTSSNS-KVIVIAATNRPDKLDPALLGRFDRIIEF 128
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
 88-271 1.74e-45

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 157.27  E-value: 1.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149   88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWY 167
Cdd:TIGR01242 119 VSYEDIGGLEEQIREIREAVELPLKHPELFEEVGI-EPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVRKYI 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  168 GESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNR----SSSDHEATAMMkAQFMSLWDGLDTDHSCQVIvmGATNRPQDL 243
Cdd:TIGR01242 198 GEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRtdsgTSGDREVQRTL-MQLLAELDGFDPRGNVKVI--AATNRPDIL 274

                         170       180       190
                  ....*....|....*....|....*....|..
gi 767964149  244 DSAIMRrmPTRF----HINQPALKQREAILKL 271
Cdd:TIGR01242 275 DPALLR--PGRFdriiEVPLPDFEGRLEILKI 304
cell_div_CdvC NF041006
cell division protein CdvC;
88-278 2.52e-44

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 154.51  E-value: 2.52e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFEnsrlLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWY 167
Cdd:NF041006 100 VTFSDIVGLEDVKEALKEAIVYPSKRPDLFP----LGWPRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWL 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 168 GESQKLAAAVFSLAIKL-----QPSIIFIDEIDSFLrNRSSSDHEATAMMKAQFMSLWDGL-DTDHSCQVIVMGATNRPQ 241
Cdd:NF041006 176 GEAEKNVAKIFKKAREKskeegKPAIIFIDEIDALL-GVYSSEVGGEVRVRNQFLKEMDGLqDKSENYHVYVIGATNKPW 254

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767964149 242 DLDSAIMRRMPTRFHINQPALKQREAILKLI---LKNEND 278
Cdd:NF041006 255 RLDEPFLRRFQKRIYIPLPDREQRLELLKYYtskIKLEND 294
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 125-254 6.20e-17

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 76.26  E-value: 6.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149   125 PPKGVLLYGPPGCGKTLIAKATAKEAGC-----------------RFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPS 187
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPpgggviyidgedileevLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767964149   188 IIFIDEIDSFLRNRSSSDheataMMKAQFMSLWDGLDTDHSCQVIvmGATNRPQDLDSAIMRRMPTR 254
Cdd:smart00382  81 VLILDEITSLLDAEQEAL-----LLLLEELRLLLLLKSEKNLTVI--LTTNDEKDLGPALLRRRFDR 140
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 129-153 8.76e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 36.68  E-value: 8.76e-03
                         10        20
                 ....*....|....*....|....*
gi 767964149 129 VLLYGPPGCGKTLIAKATAKEAgCR 153
Cdd:NF038214  93 VLLLGPPGTGKTHLAIALGYAA-CR 116
 
Name Accession Description Interval E-value
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 92-257 4.04e-121

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 343.64  E-value: 4.04e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  92 DIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQ 171
Cdd:cd19520    1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 172 KLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRM 251
Cdd:cd19520   81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160


                 ....*.
gi 767964149 252 PTRFHI 257
Cdd:cd19520  161 PKRFHI 166
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 93-257 2.66e-77

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 232.63  E-value: 2.66e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  93 IAGLDDVITDLKDTVILPIKKKHLFENSRllQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQK 172
Cdd:cd19509    1 IAGLDDAKEALKEAVILPSLRPDLFPGLR--GPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 173 LAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRMP 252
Cdd:cd19509   79 IVRALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRVKTEFLVQMDGVLNKPEDRVLVLGATNRPWELDEAFLRRFE 158


                 ....*
gi 767964149 253 TRFHI 257
Cdd:cd19509  159 KRIYI 163
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 88-279 3.26e-67

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 212.56  E-value: 3.26e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWY 167
Cdd:COG1222   75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGI-EPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYI 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 168 GESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSS-DHEATAMMKAQFMSLWDGLDTDHScqVIVMGATNRPQDLDSA 246
Cdd:COG1222  154 GEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDgTSGEVQRTVNQLLAELDGFESRGD--VLIIAATNRPDLLDPA 231

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 767964149 247 IMRrmPTRF----HINQPALKQREAILKLILKNENDS 279
Cdd:COG1222  232 LLR--PGRFdrviEVPLPDEEAREEILKIHLRDMPLA 266
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 92-257 1.63e-59

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 187.36  E-value: 1.63e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  92 DIAGLDDVITDLKDTVILPIKKKHLFENSRllQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQ 171
Cdd:cd19524    1 DIAGQDLAKQALQEMVILPSLRPELFTGLR--APARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 172 KLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRM 251
Cdd:cd19524   79 KLVRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRRF 158


                 ....*.
gi 767964149 252 PTRFHI 257
Cdd:cd19524  159 TKRVYV 164
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 85-257 7.36e-57

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 181.34  E-value: 7.36e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  85 NMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRllQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTD 164
Cdd:cd19525   16 GPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLR--GPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 165 KWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLD 244
Cdd:cd19525   94 KWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEID 173

                        170
                 ....*....|...
gi 767964149 245 SAIMRRMPTRFHI 257
Cdd:cd19525  174 EAARRRLVKRLYI 186
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 4-275 1.93e-55

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 184.34  E-value: 1.93e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149   4 AEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHLVDP 83
Cdd:COG0464   70 LLALLLLALLALLAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  84 LNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLT 163
Cdd:COG0464  150 ELREAILDDLGGLEEVKEELRELVALPLKRPELREEYGL-PPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLV 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 164 DKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDhscqVIVMGATNRPQDL 243
Cdd:COG0464  229 SKYVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNTLLTEMEELRSD----VVVIAATNRPDLL 304

                        250       260       270
                 ....*....|....*....|....*....|..
gi 767964149 244 DSAIMRRMPTRFHINQPALKQREAILKLILKN 275
Cdd:COG0464  305 DPALLRRFDEIIFFPLPDAEERLEIFRIHLRK 336
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 92-255 5.89e-55

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 175.56  E-value: 5.89e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  92 DIAGLDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQ 171
Cdd:cd19503    1 DIGGLDEQIASLKELIELPLKYPELFRALGL-KPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 172 KLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHscQVIVMGATNRPQDLDSAIMRrm 251
Cdd:cd19503   80 KNLREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGMSSRG--KVVVIAATNRPDAIDPALRR-- 155


                 ....
gi 767964149 252 PTRF 255
Cdd:cd19503  156 PGRF 159
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 87-257 1.06e-52

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 170.04  E-value: 1.06e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  87 HVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRllQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKW 166
Cdd:cd19521    3 NVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNR--KPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 167 YGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHScQVIVMGATNRPQDLDSA 246
Cdd:cd19521   81 MGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGVGNDSQ-GVLVLGATNIPWQLDSA 159

                        170
                 ....*....|.
gi 767964149 247 IMRRMPTRFHI 257
Cdd:cd19521  160 IRRRFEKRIYI 170
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 88-270 1.79e-49

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 168.47  E-value: 1.79e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWY 167
Cdd:PRK03992 128 VTYEDIGGLEEQIREVREAVELPLKKPELFEEVGI-EPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 168 GESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNR----SSSDHEA--TaMMkaQFMSLWDGLDTdhSCQVIVMGATNRPQ 241
Cdd:PRK03992 207 GEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdsgTSGDREVqrT-LM--QLLAEMDGFDP--RGNVKIIAATNRID 281

                        170       180       190
                 ....*....|....*....|....*....|...
gi 767964149 242 DLDSAIMRrmPTRF----HINQPALKQREAILK 270
Cdd:PRK03992 282 ILDPAILR--PGRFdriiEVPLPDEEGRLEILK 312
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 89-255 1.42e-47

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 157.11  E-value: 1.42e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  89 TWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYG 168
Cdd:cd19502    1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGI-EPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 169 ESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNR----SSSDHEATAMMkAQFMSLWDGLDTDHSCQVIvmGATNRPQDLD 244
Cdd:cd19502   80 EGARLVRELFEMAREKAPSIIFIDEIDAIGAKRfdsgTGGDREVQRTM-LELLNQLDGFDPRGNIKVI--MATNRPDILD 156

                        170
                 ....*....|.
gi 767964149 245 SAIMRrmPTRF 255
Cdd:cd19502  157 PALLR--PGRF 165
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 129-257 1.93e-47

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 155.06  E-value: 1.93e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  129 VLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEA 208
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 767964149  209 TAMMKAQFMSLWDGLDTDHScQVIVMGATNRPQDLDSAIMRRMPTRFHI 257
Cdd:pfam00004  81 SRRVVNQLLTELDGFTSSNS-KVIVIAATNRPDKLDPALLGRFDRIIEF 128
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 92-257 7.77e-46

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 152.45  E-value: 7.77e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  92 DIAGLDDVITDLKDTVILPIKKKHLFENSRllQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQ 171
Cdd:cd19522    1 DIADLEEAKKLLEEAVVLPMWMPEFFKGIR--RPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 172 KLAAAVFSLAIKLQPSIIFIDEIDSFLRNR-SSSDHEATAMMKAQFMSLWDGL-----DTDHSCQVIVMGATNRPQDLDS 245
Cdd:cd19522   79 KLVRLLFEMARFYAPTTIFIDEIDSICSRRgTSEEHEASRRVKSELLVQMDGVggaseNDDPSKMVMVLAATNFPWDIDE 158

                        170
                 ....*....|..
gi 767964149 246 AIMRRMPTRFHI 257
Cdd:cd19522  159 ALRRRLEKRIYI 170
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
 88-271 1.74e-45

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 157.27  E-value: 1.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149   88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWY 167
Cdd:TIGR01242 119 VSYEDIGGLEEQIREIREAVELPLKHPELFEEVGI-EPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVRKYI 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  168 GESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNR----SSSDHEATAMMkAQFMSLWDGLDTDHSCQVIvmGATNRPQDL 243
Cdd:TIGR01242 198 GEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRtdsgTSGDREVQRTL-MQLLAELDGFDPRGNVKVI--AATNRPDIL 274

                         170       180       190
                  ....*....|....*....|....*....|..
gi 767964149  244 DSAIMRrmPTRF----HINQPALKQREAILKL 271
Cdd:TIGR01242 275 DPALLR--PGRFdriiEVPLPDFEGRLEILKI 304
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 103-255 9.27e-45

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 149.36  E-value: 9.27e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 103 LKDTVILPIKKKHLFenSRL-LQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLA 181
Cdd:cd19511    5 LKEAVEWPLKHPDAF--KRLgIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQKA 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767964149 182 IKLQPSIIFIDEIDSFLRNRSSSDH-EATAMMKAQFMSLWDGLDTdhSCQVIVMGATNRPQDLDSAIMRrmPTRF 255
Cdd:cd19511   83 RQAAPCIIFFDEIDSLAPRRGQSDSsGVTDRVVSQLLTELDGIES--LKGVVVIAATNRPDMIDPALLR--PGRL 153
cell_div_CdvC NF041006
cell division protein CdvC;
88-278 2.52e-44

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 154.51  E-value: 2.52e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFEnsrlLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWY 167
Cdd:NF041006 100 VTFSDIVGLEDVKEALKEAIVYPSKRPDLFP----LGWPRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWL 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 168 GESQKLAAAVFSLAIKL-----QPSIIFIDEIDSFLrNRSSSDHEATAMMKAQFMSLWDGL-DTDHSCQVIVMGATNRPQ 241
Cdd:NF041006 176 GEAEKNVAKIFKKAREKskeegKPAIIFIDEIDALL-GVYSSEVGGEVRVRNQFLKEMDGLqDKSENYHVYVIGATNKPW 254

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767964149 242 DLDSAIMRRMPTRFHINQPALKQREAILKLI---LKNEND 278
Cdd:NF041006 255 RLDEPFLRRFQKRIYIPLPDREQRLELLKYYtskIKLEND 294
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 99-255 5.26e-44

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 147.43  E-value: 5.26e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  99 VITDLKDTVILPikKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVF 178
Cdd:cd19481    1 LKASLREAVEAP--RRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIF 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767964149 179 SLAIKLQPSIIFIDEIDSFLRNRSSS-DHEATAMMKAQFMSLWDGLDTDHscQVIVMGATNRPQDLDSAIMRrmPTRF 255
Cdd:cd19481   79 ERARRLAPCILFIDEIDAIGRKRDSSgESGELRRVLNQLLTELDGVNSRS--KVLVIAATNRPDLLDPALLR--PGRF 152
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 88-275 5.65e-44

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 159.30  E-value: 5.65e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149   88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFEnsRL-LQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKW 166
Cdd:TIGR01243 175 VTYEDIGGLKEAKEKIREMVELPMKHPELFE--HLgIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKY 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  167 YGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLdtDHSCQVIVMGATNRPQDLDSA 246
Cdd:TIGR01243 253 YGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMDGL--KGRGRVIVIGATNRPDALDPA 330

                         170       180       190
                  ....*....|....*....|....*....|...
gi 767964149  247 ImrRMPTRFH----INQPALKQREAILKLILKN 275
Cdd:TIGR01243 331 L--RRPGRFDreivIRVPDKRARKEILKVHTRN 361
pup_AAA TIGR03689
proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some ...
 88-269 8.78e-43

proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 200312 [Multi-domain]  Cd Length: 512  Bit Score: 153.33  E-value: 8.78e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149   88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCR----------FINL 157
Cdd:TIGR03689 179 VTYADIGGLGSQIEQIRDAVELPFLHPELYREYGL-KPPKGVLLYGPPGCGKTLIAKAVANSLAARigaegggksyFLNI 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  158 QPSTLTDKWYGESQKLAAAVFSLAIKL----QPSIIFIDEIDSFLRNRS---SSDHEATAMmkAQFMSLWDGLDTDHScq 230
Cdd:TIGR03689 258 KGPELLNKYVGETERQIRLIFQRAREKasegRPVIVFFDEMDSLFRTRGsgvSSDVETTVV--PQLLAEIDGVESLDN-- 333

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 767964149  231 VIVMGATNRPQDLDSAIMR--RMPTRFHINQPALKQREAIL 269
Cdd:TIGR03689 334 VIVIGASNREDMIDPAILRpgRLDVKIRIERPDAEAAADIF 374
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 92-255 9.75e-42

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 141.80  E-value: 9.75e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  92 DIAGLDDVITDLKDTVILPIKKKHLFEnSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQ 171
Cdd:cd19519    1 DIGGCRKQLAQIREMVELPLRHPELFK-AIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 172 KLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTdhSCQVIVMGATNRPQDLDSAImrRM 251
Cdd:cd19519   80 SNLRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVERRIVSQLLTLMDGLKQ--RAHVIVMAATNRPNSIDPAL--RR 155


                 ....
gi 767964149 252 PTRF 255
Cdd:cd19519  156 FGRF 159
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 54-271 5.64e-40

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 148.13  E-value: 5.64e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149   54 QAEKLMKQIgVKNVKLSEYEMSIAAHLVDPLNM--------HVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLlQP 125
Cdd:TIGR01243 409 EAEEIPAEV-LKELKVTMKDFMEALKMVEPSAIrevlvevpNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGI-RP 486

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  126 PKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSD 205
Cdd:TIGR01243 487 PKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARF 566

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767964149  206 HEA-TAMMKAQFMSLWDGLDTDHScqVIVMGATNRPQDLDSAIMRrmPTRF----HINQPALKQREAILKL 271
Cdd:TIGR01243 567 DTSvTDRIVNQLLTEMDGIQELSN--VVVIAATNRPDILDPALLR--PGRFdrliLVPPPDEEARKEIFKI 633
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 92-255 1.02e-39

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 136.87  E-value: 1.02e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  92 DIAGLDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAG-----CRFINLQPSTLTDKW 166
Cdd:cd19517    1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKI-TPPRGVLFHGPPGTGKTLMARALAAECSkggqkVSFFMRKGADCLSKW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 167 YGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTdhSCQVIVMGATNRPQDLDSA 246
Cdd:cd19517   80 VGEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGLDN--RGQVVVIGATNRPDALDPA 157


                 ....*....
gi 767964149 247 ImrRMPTRF 255
Cdd:cd19517  158 L--RRPGRF 164
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 92-249 5.09e-38

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 132.14  E-value: 5.09e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  92 DIAGLDDVITDLKDTVILPIKKKHLFENSRLLqPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQ 171
Cdd:cd19518    1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVE-PPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 172 KLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGL--DTDHSCQVIVMGATNRPQDLDSAIMR 249
Cdd:cd19518   80 EKIRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDELnnEKTAGGPVLVIGATNRPDSLDPALRR 159
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 96-255 7.62e-38

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 131.46  E-value: 7.62e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  96 LDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAA 175
Cdd:cd19530    1 LDHVREELTMSILRPIKRPDIYKALGI-DLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 176 AVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHscQVIVMGATNRPQDLDSAIMRrmPTRF 255
Cdd:cd19530   80 QVFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGLEERS--NVFVIAATNRPDIIDPAMLR--PGRL 155
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 102-255 9.96e-38

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 131.08  E-value: 9.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 102 DLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLA 181
Cdd:cd19529    4 ELKEAVEWPLLKPEVFKRLGI-RPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRKA 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767964149 182 IKLQPSIIFIDEIDSFLRNR-SSSDHEATAMMKAQFMSLWDGLDTDHscQVIVMGATNRPQDLDSAIMRrmPTRF 255
Cdd:cd19529   83 RQVAPCVIFFDEIDSIAPRRgTTGDSGVTERVVNQLLTELDGLEEMN--GVVVIAATNRPDIIDPALLR--AGRF 153
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 88-255 1.45e-36

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 128.50  E-value: 1.45e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  88 VTWSDIAGLDDVITDLKDTVilpikkKHLFENSRLLQ----PPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLT 163
Cdd:cd19501    1 VTFKDVAGCEEAKEELKEVV------EFLKNPEKFTKlgakIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 164 DKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNR---SSSDHEATAMMKAQFMSLWDGLDTDHscQVIVMGATNRP 240
Cdd:cd19501   75 EMFVGVGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRgagLGGGHDEREQTLNQLLVEMDGFESNT--GVIVIAATNRP 152

                        170
                 ....*....|....*
gi 767964149 241 QDLDSAIMRrmPTRF 255
Cdd:cd19501  153 DVLDPALLR--PGRF 165
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 99-254 6.91e-36

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 126.47  E-value: 6.91e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  99 VITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVF 178
Cdd:cd19528    1 VKRELQELVQYPVEHPDKFLKFGM-TPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIF 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767964149 179 SLAIKLQPSIIFIDEIDSFLRNRSSS---DHEATAMMKAQFMSLWDGLDTDHScqVIVMGATNRPQDLDSAIMRrmPTR 254
Cdd:cd19528   80 DKARAAAPCVLFFDELDSIAKARGGNigdAGGAADRVINQILTEMDGMNTKKN--VFIIGATNRPDIIDPAILR--PGR 154
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 92-257 6.17e-35

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 124.23  E-value: 6.17e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  92 DIAGLDDVITDLKDTVILPIKKKHLFenSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQ 171
Cdd:cd19523    1 DIAGLGALKAAIKEEVLWPLLRPDAF--SGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 172 KLAAAVFSLAIKLQPSIIFIDEIDSFLRNRsSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRM 251
Cdd:cd19523   79 KILQASFLAARCRQPSVLFISDLDALLSSQ-DDEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYF 157


                 ....*.
gi 767964149 252 PTRFHI 257
Cdd:cd19523  158 SKRLLV 163
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 88-281 6.19e-34

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 128.94  E-value: 6.19e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149   88 VTWSDIAGLDDVITDLKDTVilpikkKHLFENSRLLQ----PPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLT 163
Cdd:TIGR01241  52 VTFKDVAGIDEAKEELMEIV------DFLKNPSKFTKlgakIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFV 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  164 DKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRS---SSDHEATAMMKAQFMSLWDGLDTdhSCQVIVMGATNRP 240
Cdd:TIGR01241 126 EMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGaglGGGNDEREQTLNQLLVEMDGFGT--NTGVIVIAATNRP 203

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 767964149  241 QDLDSAIMRrmPTRFH----INQPALKQREAILKLILKNEN-DSTV 281
Cdd:TIGR01241 204 DVLDPALLR--PGRFDrqvvVDLPDIKGREEILKVHAKNKKlAPDV 247
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 81-271 3.89e-32

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 123.34  E-value: 3.89e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  81 VDPLN--MHV------TWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGC 152
Cdd:PTZ00361 165 VDPLVsvMKVdkapleSYADIGGLEQQIQEIKEAVELPLTHPELYDDIGI-KPPKGVILYGPPGTGKTLLAKAVANETSA 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 153 RFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDT-DHSCQV 231
Cdd:PTZ00361 244 TFLRVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSGGEKEIQRTMLELLNQLDGfDSRGDV 323

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 767964149 232 IVMGATNRPQDLDSAIMR--RMPTRFHINQPALKQREAILKL 271
Cdd:PTZ00361 324 KVIMATNRIESLDPALIRpgRIDRKIEFPNPDEKTKRRIFEI 365
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 88-279 6.61e-32

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 122.18  E-value: 6.61e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  88 VTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWY 167
Cdd:PTZ00454 142 VTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGI-DPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYL 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 168 GESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNR----SSSDHEATAMMkAQFMSLWDGLDTDHSCQVIVmgATNRPQDL 243
Cdd:PTZ00454 221 GEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfdaqTGADREVQRIL-LELLNQMDGFDQTTNVKVIM--ATNRADTL 297

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 767964149 244 DSAIMR--RMPTRFHINQPALKQREAILKLILKNENDS 279
Cdd:PTZ00454 298 DPALLRpgRLDRKIEFPLPDRRQKRLIFQTITSKMNLS 335
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
123-274 2.14e-31

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 117.29  E-value: 2.14e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 123 LQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAiKLQPSIIFIDEIDSFLRNRS 202
Cdd:COG1223   32 LWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETARNLRKLFDFA-RRAPCVIFFDEFDAIAKDRG 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767964149 203 SSdhEATAMMKA------QFMslwDGLDTDhscqVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQREAILKLILK 274
Cdd:COG1223  111 DQ--NDVGEVKRvvnallQEL---DGLPSG----SVVIAATNHPELLDSALWRRFDEVIEFPLPDKEERKEILELNLK 179
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 103-255 2.95e-31

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 114.45  E-value: 2.95e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 103 LKDTVILPIKKKHLFENSRLLQPpKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAI 182
Cdd:cd19526    5 LEETIEWPSKYPKIFASSPLRLR-SGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFSRAQ 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767964149 183 KLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHScqVIVMGATNRPQDLDSAIMRrmPTRF 255
Cdd:cd19526   84 SAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQLDGVEGLDG--VYVLAATSRPDLIDPALLR--PGRL 152
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 99-255 3.27e-30

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 111.84  E-value: 3.27e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  99 VITDLKDTVILPIKKKHLFenSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVF 178
Cdd:cd19527    1 VKKEILDTIQLPLEHPELF--SSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVF 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767964149 179 SLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMK--AQFMSLWDGLDTDHScQVIVMGATNRPQDLDSAIMRrmPTRF 255
Cdd:cd19527   79 QKARDAKPCVIFFDELDSLAPSRGNSGDSGGVMDRvvSQLLAELDGMSSSGQ-DVFVIGATNRPDLLDPALLR--PGRF 154
ftsH CHL00176
cell division protein; Validated
 88-277 5.72e-30

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 119.00  E-value: 5.72e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  88 VTWSDIAGLDDVITDLKDTVILpIKKKHLFENSRLlQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWY 167
Cdd:CHL00176 180 ITFRDIAGIEEAKEEFEEVVSF-LKKPERFTAVGA-KIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFV 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 168 GesqkLAAA----VFSLAIKLQPSIIFIDEIDSFLRNRSS-----SDHEATAMMkaQFMSLWDGL--DTDhscqVIVMGA 236
Cdd:CHL00176 258 G----VGAArvrdLFKKAKENSPCIVFIDEIDAVGRQRGAgigggNDEREQTLN--QLLTEMDGFkgNKG----VIVIAA 327

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 767964149 237 TNRPQDLDSAIMRrmPTRFH----INQPALKQREAILKLILKNEN 277
Cdd:CHL00176 328 TNRVDILDAALLR--PGRFDrqitVSLPDREGRLDILKVHARNKK 370
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
74-275 7.58e-28

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 112.82  E-value: 7.58e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  74 MSIA---AHLVDPLNMHVTWSDIAGLDDVITDLKDTVilpikkkhlfenSRLLQP----------PKGVLLYGPPGCGKT 140
Cdd:COG0465  122 MSFGkskAKLYDEDKPKVTFDDVAGVDEAKEELQEIV------------DFLKDPekftrlgakiPKGVLLVGPPGTGKT 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 141 LIAKATAKEAGCRFINLQPSTLTDKWYGesqkLAAA----VFSLAIKLQPSIIFIDEIDSFLRNRSSS------DHEAT- 209
Cdd:COG0465  190 LLAKAVAGEAGVPFFSISGSDFVEMFVG----VGASrvrdLFEQAKKNAPCIIFIDEIDAVGRQRGAGlggghdEREQTl 265

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767964149 210 ----AMMkaqfmslwDGLDTDHScqVIVMGATNRPQDLDSAIMRrmPTRF----HINQPALKQREAILKLILKN 275
Cdd:COG0465  266 nqllVEM--------DGFEGNEG--VIVIAATNRPDVLDPALLR--PGRFdrqvVVDLPDVKGREAILKVHARK 327
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
78-274 4.69e-26

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 107.81  E-value: 4.69e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  78 AHLVDPLNMHVTWSDIAGLDDVITDLKDTVilpikkKHLFENSRLLQ----PPKGVLLYGPPGCGKTLIAKATAKEAGCR 153
Cdd:PRK10733 139 ARMLTEDQIKTTFADVAGCDEAKEEVAELV------EYLREPSRFQKlggkIPKGVLMVGPPGTGKTLLAKAIAGEAKVP 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 154 FINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSS---SDHEATAMMKAQFMSLWDGLDTDHScq 230
Cdd:PRK10733 213 FFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAglgGGHDEREQTLNQMLVEMDGFEGNEG-- 290

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767964149 231 VIVMGATNRPQDLDSAIMRrmPTRFH----INQPALKQREAILKLILK 274
Cdd:PRK10733 291 IIVIAATNRPDVLDPALLR--PGRFDrqvvVGLPDVRGREQILKVHMR 336
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 114-259 1.56e-22

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 91.05  E-value: 1.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 114 KHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEA---GCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKL---QPS 187
Cdd:cd00009    7 IEALREALELPPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGHFLVRLLFELAekaKPG 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767964149 188 IIFIDEIDSFLRnrssSDHEATAMMKAQFMSLWDGLDTdhscqVIVMGATNRP--QDLDSAIMRRMPTRFHINQ 259
Cdd:cd00009   87 VLFIDEIDSLSR----GAQNALLRVLETLNDLRIDREN-----VRVIGATNRPllGDLDRALYDRLDIRIVIPL 151
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 92-250 1.39e-17

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 78.18  E-value: 1.39e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  92 DIAGLDDvitdLKDtvILPIKKKHLFENSRL--LQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGE 169
Cdd:cd19507    1 DVGGLDN----LKD--WLKKRKAAFSKQASAygLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 170 SQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNR-SSSDHEATAMMKAQFMSlWdglDTDHSCQVIVMGATNRPQDLDSAIM 248
Cdd:cd19507   75 SESRLRQMIQTAEAIAPCVLWIDEIEKGFSNAdSKGDSGTSSRVLGTFLT-W---LQEKKKPVFVVATANNVQSLPPELL 150


                 ..
gi 767964149 249 RR 250
Cdd:cd19507  151 RK 152
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 125-254 6.20e-17

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 76.26  E-value: 6.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149   125 PPKGVLLYGPPGCGKTLIAKATAKEAGC-----------------RFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPS 187
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPpgggviyidgedileevLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767964149   188 IIFIDEIDSFLRNRSSSDheataMMKAQFMSLWDGLDTDHSCQVIvmGATNRPQDLDSAIMRRMPTR 254
Cdd:smart00382  81 VLILDEITSLLDAEQEAL-----LLLLEELRLLLLLKSEKNLTVI--LTTNDEKDLGPALLRRRFDR 140
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 119-257 1.37e-15

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 73.29  E-value: 1.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 119 NSRLLQPP----------KGVLLYGPPGCGKTLIAKATAKEAGCR---FINlQPSTLtDKWYGESQKLAAAVFSLAIKLQ 185
Cdd:cd19504   18 ASRVFPPEiveqlgckhvKGILLYGPPGTGKTLMARQIGKMLNARepkIVN-GPEIL-NKYVGESEANIRKLFADAEEEQ 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 186 PS--------IIFIDEIDSFLRNRSSS--DHEATAMMKAQFMSLWDGLDTDHScqVIVMGATNRPQDLDSAIMRrmPTRF 255
Cdd:cd19504   96 RRlgansglhIIIFDEIDAICKQRGSMagSTGVHDTVVNQLLSKIDGVEQLNN--ILVIGMTNRKDLIDEALLR--PGRL 171


                 ..
gi 767964149 256 HI 257
Cdd:cd19504  172 EV 173
ycf46 CHL00195
Ycf46; Provisional
 88-274 8.01e-14

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 71.20  E-value: 8.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  88 VTWSDIAGLDDVITDLKdtvilpiKKKHLFENSRL---LQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTD 164
Cdd:CHL00195 225 EKISDIGGLDNLKDWLK-------KRSTSFSKQASnygLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLFG 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 165 KWYGESQKLAAAVFSLAIKLQPSIIFIDEID-SFLRNRSSSDHEATAMMKAQFMSlWdgLDTDHScQVIVMGATNRPQDL 243
Cdd:CHL00195 298 GIVGESESRMRQMIRIAEALSPCILWIDEIDkAFSNSESKGDSGTTNRVLATFIT-W--LSEKKS-PVFVVATANNIDLL 373

                        170       180       190
                 ....*....|....*....|....*....|...
gi 767964149 244 DSAIMR--RMPTRFHINQPALKQREAILKLILK 274
Cdd:CHL00195 374 PLEILRkgRFDEIFFLDLPSLEEREKIFKIHLQ 406
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 127-251 2.36e-11

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 60.62  E-value: 2.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 127 KGVLLYGPPGCGKTLIAKATAKEAGCRFINLqpsTLTDKWYGESQKLAA--AVFSLAIKLQPS-IIFIDEIDSFLRNRSS 203
Cdd:cd19512   23 RNILFYGPPGTGKTLFAKKLALHSGMDYAIM---TGGDVAPMGREGVTAihKVFDWANTSRRGlLLFVDEADAFLRKRST 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767964149 204 sdheaTAMMKAQFMSLWDGL--DTDHSCQVIVMGATNRPQDLDSAIMRRM 251
Cdd:cd19512  100 -----EKISEDLRAALNAFLyrTGEQSNKFMLVLASNQPEQFDWAINDRI 144
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 108-244 2.26e-10

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 58.31  E-value: 2.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 108 ILPIKKKHLFENSRLLqppKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGES--QKLAAAVFSLAIKLQ 185
Cdd:cd19506   11 ILPLGSQAVHEKAPLV---KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQ 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767964149 186 PSIIFIDEID-SFLRNRSSSDHEAT-AMMKAQFMSLWDGLDTDHscQVIVMGATNRPQDLD 244
Cdd:cd19506   88 PSVIWIGDAEkTFYKKVPKTEKQLDpKRLKKDLPKILKSLKPED--RVLIVGTTSRPFEAD 146
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 127-257 2.61e-09

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 55.05  E-value: 2.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 127 KGVLLYGPPGCGKTLIAKATAKEAGCRF--INLQPSTLTDkwygESQKLAaavfsLAIKLQPSIIFIDEIDSFLrnrSSS 204
Cdd:cd19510   24 RGYLLYGPPGTGKSSFIAALAGELDYDIcdLNLSEVVLTD----DRLNHL-----LNTAPKQSIILLEDIDAAF---ESR 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767964149 205 DHEATAMMKAQFMS------LWDGLD--TDHSCQVIVMgATNRPQDLDSAIMR--RMPTRFHI 257
Cdd:cd19510   92 EHNKKNPSAYGGLSrvtfsgLLNALDgvASSEERIVFM-TTNHIERLDPALIRpgRVDMKIYM 153
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 119-257 4.38e-09

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 55.15  E-value: 4.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 119 NSRLLQPPKGVLLYGPPGCGKTLIAKATAKE---------AGCRFINLQPSTLTDKWYGESQKLAAAVFSLA---IKLQP 186
Cdd:cd19508   45 NTNLITWNRLVLLHGPPGTGKTSLCKALAQKlsirlssryRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIqelIDDKD 124

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767964149 187 SIIF--IDEIDSF--LRNRSSSDHEATAMMKA--QFMSLWDGLDTDHScqVIVMGATNRPQDLDSAIMRRMPTRFHI 257
Cdd:cd19508  125 ALVFvlIDEVESLaaARSASSSGTEPSDAIRVvnAVLTQIDRIKRYHN--NVILLTSNLLEKIDVAFVDRADIKQYI 199
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 126-254 5.22e-09

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 54.69  E-value: 5.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 126 PKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYgesqkLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSD 205
Cdd:cd19498   46 PKNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEVGY-----VGRDVESIIRDLVEGIVFIDEIDKIAKRGGSSG 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767964149 206 HEATAM-MKAQFMSLWDG---------LDTDHsCQVIVMGATN--RPQDLDSAIMRRMPTR 254
Cdd:cd19498  121 PDVSREgVQRDLLPIVEGstvstkygpVKTDH-ILFIAAGAFHvaKPSDLIPELQGRFPIR 180
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 129-198 2.56e-08

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 54.32  E-value: 2.56e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767964149 129 VLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKwygESQKLAAAVFSLAIKLQPSIIFIDEI--------DSFL 198
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEALSAVTSGVK---DLREVIEEARQRRSAGRRTILFIDEIhrfnkaqqDALL 113
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 129-198 3.86e-07

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 50.82  E-value: 3.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 129 VLLYGPPGCGKTLIAKATAKEAGCRFINLqpstltdkwygesqklaAAVFS--------------LAIKLQPSIIFIDEI 194
Cdd:COG2256   52 MILWGPPGTGKTTLARLIANATDAEFVAL-----------------SAVTSgvkdirevieeareRRAYGRRTILFVDEI 114

                         90
                 ....*....|..
gi 767964149 195 --------DSFL 198
Cdd:COG2256  115 hrfnkaqqDALL 126
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
 129-195 1.62e-06

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 48.37  E-value: 1.62e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767964149 129 VLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWY-GES-----QKL-AAAVFSLAiKLQPSIIFIDEID 195
Cdd:cd19497   53 ILLIGPTGSGKTLLAQTLAKILDVPFAIADATTLTEAGYvGEDvenilLKLlQAADYDVE-RAQRGIVYIDEID 125
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 129-195 5.28e-06

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 47.08  E-value: 5.28e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767964149 129 VLLYGPPGCGKTLIAKATAKEAGCRFINLQ------PSTLT-----DKWYGESQKLAAAVFSlaiklqpSIIFIDEID 195
Cdd:COG0714   34 LLLEGVPGVGKTTLAKALARALGLPFIRIQftpdllPSDILgtyiyDQQTGEFEFRPGPLFA-------NVLLADEIN 104
clpX PRK05342
ATP-dependent Clp protease ATP-binding subunit ClpX;
129-195 6.80e-06

ATP-dependent Clp protease ATP-binding subunit ClpX;


Pssm-ID: 235422 [Multi-domain]  Cd Length: 412  Bit Score: 47.08  E-value: 6.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 129 VLLYGPPGCGKTLIAKATAkeagcRFINLqP------STLTDKWY-GES-----QKL-AAAVFSLAiKLQPSIIFIDEID 195
Cdd:PRK05342 111 ILLIGPTGSGKTLLAQTLA-----RILDV-PfaiadaTTLTEAGYvGEDvenilLKLlQAADYDVE-KAQRGIVYIDEID 183
PRK04195 PRK04195
replication factor C large subunit; Provisional
 124-195 1.33e-05

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 46.45  E-value: 1.33e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767964149 124 QPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPStltDKWYGESQK----LAAAVFSL-AIKLQpsIIFIDEID 195
Cdd:PRK04195  37 KPKKALLLYGPPGVGKTSLAHALANDYGWEVIELNAS---DQRTADVIErvagEAATSGSLfGARRK--LILLDEVD 108
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 129-194 4.15e-05

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 42.87  E-value: 4.15e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767964149  129 VLLYGPPGCGKTLIAKATAKEAGcrfINLQPST--LTDKwygeSQKLAAavfsLAIKLQP-SIIFIDEI 194
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEMG---VNIRITSgpAIER----PGDLAA----ILTNLEPgDVLFIDEI 93
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
129-194 6.31e-05

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 43.97  E-value: 6.31e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767964149 129 VLLYGPPGCGKTLIAKATAKE--AGCRFIN---LQ-PSTLtdkwygesqklaAAVFSLaikLQP-SIIFIDEI 194
Cdd:PRK00080  54 VLLYGPPGLGKTTLANIIANEmgVNIRITSgpaLEkPGDL------------AAILTN---LEEgDVLFIDEI 111
ClpX COG1219
ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein ...
 129-195 1.51e-04

ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440832 [Multi-domain]  Cd Length: 409  Bit Score: 42.73  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 129 VLLYGPPGCGKTLIAKATAkeagcRFINLqP------STLTDKWY-GES-----QKL-AAAVFSLAiKLQPSIIFIDEID 195
Cdd:COG1219  112 ILLIGPTGSGKTLLAQTLA-----RILDV-PfaiadaTTLTEAGYvGEDvenilLKLlQAADYDVE-KAERGIIYIDEID 184
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 126-195 1.51e-04

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 41.41  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  126 PKGV-LLYGPPGCGKTLIAKATAKEAG---CRFINLQPSTLTDKW--------------YGESQKLAAAVfslaIKLQPS 187
Cdd:pfam07724   2 PIGSfLFLGPTGVGKTELAKALAELLFgdeRALIRIDMSEYMEEHsvsrligappgyvgYEEGGQLTEAV----RRKPYS 77


                  ....*...
gi 767964149  188 IIFIDEID 195
Cdd:pfam07724  78 IVLIDEIE 85
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
127-151 2.35e-04

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 42.26  E-value: 2.35e-04
                         10        20
                 ....*....|....*....|....*
gi 767964149 127 KGVLLYGPPGCGKTLIAKATAKEAG 151
Cdd:COG1224   65 KGILIVGPPGTGKTALAVAIARELG 89
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
 129-194 2.99e-04

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 41.90  E-value: 2.99e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767964149  129 VLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLtdkwygESQKLAAAVFSLaikLQP-SIIFIDEI 194
Cdd:TIGR00635  33 LLLYGPPGLGKTTLAHIIANEMGVNLKITSGPAL------EKPGDLAAILTN---LEEgDVLFIDEI 90
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 123-247 3.47e-04

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 40.44  E-value: 3.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 123 LQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKW--------------YGESQKLAAAVFSLAIKLQPSI 188
Cdd:cd19505    9 LSPSKGILLIGSIETGRSYLIKSLAANSYVPLIRISLNKLLYNKpdfgnddwidgmliLKESLHRLNLQFELAKAMSPCI 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767964149 189 IFIDEIDSFLRNRSSSDHEATAMMKAQFM--SLWDGLDTDHSCQVIVMGATNRPQDLDSAI 247
Cdd:cd19505   89 IWIPNIHELNVNRSTQNLEEDPKLLLGLLlnYLSRDFEKSSTRNILVIASTHIPQKVDPAL 149
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 122-160 5.47e-04

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 41.29  E-value: 5.47e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767964149 122 LLQPPKGVLLYGPPGCGKTLIAKATAKEAG------CRFINLQPS 160
Cdd:COG1401  217 ALKTKKNVILAGPPGTGKTYLARRLAEALGgedngrIEFVQFHPS 261
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
108-194 6.38e-04

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 41.08  E-value: 6.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 108 ILPIKKKHLFEN-SRLLQPPKGVLLYGPPGCGKTLIAKATAKE-AGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKlq 185
Cdd:COG1373    1 VMIMIKRKILDKlLKLLDNRKAVVITGPRQVGKTTLLKQLAKElENILYINLDDPRLRALAEEDPDDLLEALKELYPG-- 78


                 ....*....
gi 767964149 186 PSIIFIDEI 194
Cdd:COG1373   79 KTYLFLDEI 87
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 129-168 9.28e-04

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 37.97  E-value: 9.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767964149  129 VLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLT-----DKWYG 168
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLARALLKKLGLPKDSVYSrnpddDFWDG 45
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 123-198 1.30e-03

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 38.77  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 123 LQPPKG--VLLYGPPGCGKTLIAKATA----KEAGCRFINLQPSTLTDKW-------------YGESQKLAAAvfsLAIK 183
Cdd:cd00267   20 LTLKAGeiVALVGPNGSGKSTLLRAIAgllkPTSGEILIDGKDIAKLPLEelrrrigyvpqlsGGQRQRVALA---RALL 96

                         90
                 ....*....|....*
gi 767964149 184 LQPSIIFIDEIDSFL 198
Cdd:cd00267   97 LNPDLLLLDEPTSGL 111
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
 129-194 1.70e-03

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 39.29  E-value: 1.70e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767964149 129 VLLYGPPGCGKTLIAKATAKEAGCRFI-----NLQ-PSTLtdkwygesqklaAAVFSlaiKLQP-SIIFIDEI 194
Cdd:COG2255   57 VLLYGPPGLGKTTLAHIIANEMGVNIRitsgpAIEkPGDL------------AAILT---NLEEgDVLFIDEI 114
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
120-149 1.72e-03

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 39.45  E-value: 1.72e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767964149 120 SRLLQP------PKGVLLYGPPGCGKTLIAKATAKE 149
Cdd:COG1474   39 ASALRPalrgerPSNVLIYGPTGTGKTAVAKYVLEE 74
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 124-245 1.78e-03

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 39.54  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  124 QPPKGVLLYGPPGCGKTLIAKATAKEA-------GCRF----INLQP-STLTD---------KWYGES--------QKLA 174
Cdd:TIGR02928  38 SRPSNVFIYGKTGTGKTAVTKYVMKELeeaaedrDVRVvtvyVNCQIlDTLYQvlvelanqlRGSGEEvpttglstSEVF 117

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767964149  175 AAVFSLAIKLQPSIIFI-DEIDSFLRNRSSSDHEATammKAQFMSlwdglDTDhSCQVIVMGATNRPQDLDS 245
Cdd:TIGR02928 118 RRLYKELNERGDSLIIVlDEIDYLVGDDDDLLYQLS---RARSNG-----DLD-NAKVGVIGISNDLKFREN 180
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 129-156 3.10e-03

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 37.23  E-value: 3.10e-03
                         10        20
                 ....*....|....*....|....*...
gi 767964149 129 VLLYGPPGCGKTLIAKATAKEAGCRFIN 156
Cdd:cd02021    2 IVVMGVSGSGKSTVGKALAERLGAPFID 29
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
89-148 3.18e-03

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 38.63  E-value: 3.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149  89 TWSDIAGLDDVITDLKdtvilpikkkHLFENSRLlqpPKGVLLYGPPGCGKTLIAKATAK 148
Cdd:COG2812    8 TFDDVVGQEHVVRTLK----------NALASGRL---AHAYLFTGPRGVGKTTLARILAK 54
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
126-153 3.57e-03

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 38.42  E-value: 3.57e-03
                         10        20
                 ....*....|....*....|....*...
gi 767964149 126 PKGVLLYGPPGCGKTLIAKATAKEAGCR 153
Cdd:COG0470   18 PHALLLHGPPGIGKTTLALALARDLLCE 45
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 129-145 4.11e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 37.51  E-value: 4.11e-03
                          10
                  ....*....|....*..
gi 767964149  129 VLLYGPPGCGKTLIAKA 145
Cdd:pfam01078  25 LLMIGPPGSGKTMLAKR 41
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 127-151 4.67e-03

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 38.06  E-value: 4.67e-03
                          10        20
                  ....*....|....*....|....*
gi 767964149  127 KGVLLYGPPGCGKTLIAKATAKEAG 151
Cdd:pfam06068  51 RAVLIAGPPGTGKTALAIAISKELG 75
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
127-153 4.75e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 37.84  E-value: 4.75e-03
                         10        20
                 ....*....|....*....|....*..
gi 767964149 127 KGVLLYGPPGCGKTLIAKATAKEAgCR 153
Cdd:COG1484  100 ENLILLGPPGTGKTHLAIALGHEA-CR 125
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 92-155 6.50e-03

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 36.77  E-value: 6.50e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767964149  92 DIAGLDDVitdlKDTVI--LPIKKkhlfensrLLQPPKG--VLLYGPPGCGKTLIAKATAKEAGCRFI 155
Cdd:cd19500   11 DHYGLEDV----KERILeyLAVRK--------LKGSMKGpiLCLVGPPGVGKTSLGKSIARALGRKFV 66
PRK04182 PRK04182
cytidylate kinase; Provisional
 133-156 7.18e-03

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 36.71  E-value: 7.18e-03
                         10        20
                 ....*....|....*....|....
gi 767964149 133 GPPGCGKTLIAKATAKEAGCRFIN 156
Cdd:PRK04182   7 GPPGSGKTTVARLLAEKLGLKHVS 30
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 129-153 8.76e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 36.68  E-value: 8.76e-03
                         10        20
                 ....*....|....*....|....*
gi 767964149 129 VLLYGPPGCGKTLIAKATAKEAgCR 153
Cdd:NF038214  93 VLLLGPPGTGKTHLAIALGYAA-CR 116
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
 129-256 9.77e-03

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 35.56  E-value: 9.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964149 129 VLLYGPPGCGKTLIAKATAKEA---GCRFINLqpSTLtdkwygesQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSsd 205
Cdd:cd01120    1 ILITGPPGSGKTTLLLQFAEQAllsDEPVIFI--SFL--------DTILEAIEDLIEEKKLDIIIIDSLSSLARASQG-- 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767964149 206 hEATAMMKAQFMSLWDGLDTDHSCQVIVmgaTNRPQDLDSAIMRRMPTRFH 256
Cdd:cd01120   69 -DRSSELLEDLAKLLRAARNTGITVIAT---IHSDKFDIDRGGSSNDERLL 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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